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Institute
Acharya, Shreyasi ; Adamová, Dagmar ; Adler, Alexander ; Adolfsson, Jonatan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akbar, Zaenal ; Akindinov, Alexander ; Al-Turany, Mohammad ; Noor Alam, Sk ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Ruben Alfaro Molina, Jose ; Ali, Bushra ; Ali, Yasir ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altenkämper, Lucas ; Altsybeev, Igor ; Naji Anaam, Mustafa ; Andrei, Cristian ; Andreou, Dimitra ; Andronic, Anton ; Angeletti, Massimo ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Chandra, Anuj ; Apadula, Nicole ; Bernard Aphecetche, Laurent ; Appelshäuser, Harald ; Arcelli, Silvia ; Arnaldi, Roberta ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Aziz, Sizar ; Danish Azmi, Mohd ; Badalà, Angela ; Baek, Yong Wook ; Bai, X. ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Bala, Remu ; Balbino, Alessandro ; Baldisseri, Alberto ; Balis, Bartosz ; Ball, Markus ; Banerjee, Debjani ; Barbera, Roberto ; Barioglio, Luca ; Barlou, Maria ; Gabor Barnaföldi, Gergely ; Stuart Barnby, Lee ; Barret, Valerie ; Bartels, Clara ; Barth, Klaus ; Bartsch, Esther ; Baruffaldi, Filippo ; Bastid, Nicole ; Basu, Sumit ; Batigne, Guillaume ; Batyunya, Boris ; Bauri, Dibakar ; Bazo Alba, Jose Luis ; Gardner Bearden, Ian ; Beattie, Caitlin ; Belikov, Iouri ; Bell Hechavarria, Ailec de la Caridad ; Bellini, Francesca ; Bellwied, Rene ; Belokurova, Svetlana ; Belyaev, Vladimir ; Bencédi, Gyula ; Beolè, Stefania ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berdnikova, Anastasia ; Bergmann, Luisa ; Gabriela Besoiu, Mihaela ; Betev, Latchezar ; Pratim Bhaduri, Partha ; Bhasin, Anju ; Asif Bhat, Mohammad ; Bhattacharjee, Buddhadeb ; Bhattacharya, Purba ; Bianchi, Livio ; Bianchi, Nicola ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biernat, Jacek ; Bilandzic, Ante ; Biro, Gabor ; Biswas, Saikat ; Thomas Blair, Justin ; Blau, Dmitry S. ; Blidaru, Mihail-Bogdan ; Blume, Christoph ; Boca, Gianluigi ; Bock, Friederike ; Bogdanov, Alexey A. ; Boi, Stefano ; Bok, Jeongsu ; Boldizsar, Laszlo ; Bolozdynya, Alexander I. ; Bombara, Marek ; Matthew Bond, Peter ; Bonomi, Germano ; Borel, Herve ; Borissov, Alexander ; Bossi, Hannah ; Botta, Elena ; Bratrud, Lars ; Braun-Munzinger, Peter ; Bregant, Marco ; Broz, Michal ; Eugenio Bruno, Giuseppe ; Daniel Buckland, Matthew ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bugnon, Ophélie ; Bühler, Paul ; Buthelezi, Edith Zinhle ; Bashir Butt, Jamila ; Bysiak, Sebastian Adam ; Caffarri, Davide ; Cai, M. ; Caines, Helen Louise ; Caliva, Alberto ; Calvo Villar, Ernesto ; Manuel Mejia Camacho, Juan ; Soto Camacho, Rabi ; Camerini, Paolo ; Canedo, Fabio de Moraes ; Carnesecchi, Francesca ; Albert Andre Caron, Robin ; Castillo Castellanos, Javier Ernesto ; Anna Rita Casula, Ester ; Catalano, Fabio ; Ceballos Sanchez, Cesar ; Chakraborty, Pritam ; Chandra, Sinjini ; Chapeland, Sylvain ; Chartier, Marielle ; Chattopadhyay, S. ; Chattopadhyay, S. ; Henri Jean Chauvin, Alex ; García Chávez, Tonatiuh ; Valeriev Cheshkov, Cvetan ; Cheynis, Brigitte ; Miguel Chibante Barroso, Vasco ; Chinellato, David Dobrigkeit ; Cho, Soyeon ; Chochula, Peter ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Rudolf Ciupek, Michael ; Clai, Giulia ; Willy Andre Cleymans, Jean ; Colamaria, Fabio Filippo ; Samuel Colburn, Jonathan ; Colella, Domenico ; Collu, Alberto ; Colocci, Manuel ; Concas, Matteo ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Louis Coquet, Maurice ; Cormier, Thomas Michael ; Cortese, Pietro ; Rogerio Cosentino, Mauro ; Costa, Filippo ; Costanza, Susanna ; Crochet, Philippe ; Cruz Torres, Reynier ; Cuautle Flores, Eleazar ; Cui, Pengyao ; Cunqueiro Mendez, Leticia ; Dainese, Andrea ; Damas, F. P. A. ; Charlotte Danisch, Meike ; Danu, Andrea ; Das, Indranil ; Das, Prottay ; Das, Prottay ; Das, Supriya ; Dash, Sadhana ; De, Sudipan ; De Caro, Annalisa ; De Cataldo, Giacinto ; De Cilladi, Lorenzo ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, Suman ; Degenhardt, Hermann Franz ; Rafal Deja, Kamil ; Dello Stritto, Luigi ; Delsanto, Silvia ; Deng, W. ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Diaz, R. 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K. ; Singhal, Vikas ; Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skorodumovs, Georgijs ; Slupecki, Maciej ; Smirnov, Nikolai ; Snellings, Raimond ; Soncco Meza, Carlos ; Song, J. ; Songmoolnak, Arnon ; Soramel, Francesca ; Sorensen, Soren Pontoppidan ; Anna Sputowska, Iwona ; Stachel, Johanna ; Stan, Ionel ; John Steffanic, Patrick ; Stiefelmaier, Stephan ; Stocco, Diego ; Storehaug, Ida ; Melnik Storetvedt, Maksim ; Pliatskas Stylianidis, Christos ; Suaide, Alexandre Alarcon do Passo ; Sugitate, Toru ; Suire, Christophe Pierre ; Šuljić, Miljenko ; Sultanov, Rishat ; Šumbera, Michal ; Sumberia, Vikash ; Sumowidagdo, Suharyo ; Swain, Sagarika ; Szabo, Alexander ; Szarka, Imrich ; Tabassam, Uzma ; Taghavi, Seyed Farid ; Taillepied, Guillaume ; Takahashi, Jun ; Tambave, Ganesh ; Tang, S. ; Tang, Z. ; Tarhini, Mohamad ; Tarzila, Madalina-Gabriela ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terlizzi, Livia ; Terrevoli, Cristina ; Tersimonov, Georgy ; Thakur, Sanchari ; Thomas, Deepa ; Noel Tieulent, Raphael ; Tikhonov, Anatoly ; Timmins, Anthony Robert ; Tkacik, Milan ; Toia, Alberica ; Topilskaya, Nataliya ; Toppi, Marco ; Torales Acosta, Fernando ; Tork, T. ; Rojas Torres, Solangel ; Trifiro, Antonio ; Tripathy, Sushanta ; Tripathy, Tulika ; Trogolo, Stefano ; Trombetta, Giuseppe ; Trubnikov, Victor ; Trzaska, Wladyslaw Henryk ; Trzcinski, Tomasz Piotr ; Antonina Trzeciak, Barbara ; Tumkin, Alexandr ; Turrisi, Rosario ; Spedstad Tveter, Trine ; Ullaland, Kjetil ; Uras, Antonio ; Urioni, Marta ; Usai, Gianluca ; Vala, Martin ; Valle, Nicolò ; Vallero, Sara ; Kolk, Naomi van der ; Doremalen, Lennart Vincent Rogier van ; Leeuwen, Marco van ; Vyvre, Pierre vande ; Varga, Dezsö ; Varga, Zoltán ; Varga-Kofarago, Monika ; Aurora Diozcora Vargas Treviño, Maria ; Vasileiou, Maria ; Vasiliev, Andrey ; Vázquez Doce, Oton ; Vechernin, Vladimir ; Vercellin, Ermanno ; Vergara Limon, Sergio ; Vermunt, Lucas Anne ; Vértesi, Róbert ; Verweij, Marta ; Vicković, Linda ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vino, Gioacchino ; Vinogradov, Alexander ; Virgili, Tiziano ; Vislavicius, Vytautas ; Vodopyanov, Alexander ; Völkel, Benedikt ; Völkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vorobyev, Ivan ; Voscek, Dominik ; Vozniuk, Nikita ; Vrláková, Janka ; Wagner, Boris ; Wang, C. ; Wang, D. ; Weber, Michael ; Jan Gijs van Weelden, Roelof ; Wegrzynek, Adami Tadeusz ; Wenzel, Sandro Christian ; Wessels, Johannes P. ; Wiechula, Jens ; Wikne, Jon ; Andrzej Wilk, Grzegorz ; Wilkinson, Jeremy ; Alexander Willems, Guido ; Windelband, Bernd ; Winn, Michael ; Edward Witt, William ; Rae Wright, Josephina ; Wu, W. ; Wu, Y. ; Xu, Ran ; Yalcin, Serpil ; Yamaguchi, Yorito ; Yamakawa, Kosei ; Yang, S. ; Yano, Satoshi ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yoon, Jin-Hee ; Yuan, S. ; Yüncü, Alperen ; Zaccolo, Valentina ; Zaman, Ali ; Zampolli, Chiara ; Jose Correia Zanoli, Henrique ; Zardoshti, Nima ; Zarochentsev, Andrey ; Závada, Petr ; Zaviyalov, Nikolaj ; Zbroszczyk, Hanna Paulina ; Zhalov, Mikhail ; Zhang, S. ; Zhang, X. ; Zhang, Y. ; Zherebchevskii, Vladimir ; Zhi, Y. ; Zhigareva, Natalia ; Zhou, D. ; Zhou, Y. ; Zhu, J. ; Zhu, Y. ; Zichichi, Antonino ; Zinovjev, Gennady M. ; Zurlo, Nicola
At particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD). The vacuum is not transparent to the partons and induces gluon radiation and quark pair production in a process that can be described as a parton shower. Studying the pattern of the parton shower is one of the key experimental tools in understanding the properties of QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass m and energy E, within a cone of angular size m/E around the emitter. A direct observation of the dead-cone effect in QCD has not been possible until now, due to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible bound hadronic states. We report the first direct observation of the QCD dead-cone by using new iterative declustering techniques to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD, which is derived more generally from its origin as a gauge quantum field theory. Furthermore, the measurement of a dead-cone angle constitutes a direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics.
Dietrich, Sascha ; Oleś, Małgorzata ; Lu, Junyan ; Sellner, Leopold ; Anders, Simon ; Velten, Britta ; Wu, Bian ; Hüllein, Jennifer ; Silva Liberio, Michelle da ; Walther, Tatjana ; Wagner, Lena ; Rabe, Sophie ; Ghidelli-Disse, Sonja ; Bantscheff, Marcus ; Oleś, Andrzej K. ; Słabicki, Mikołaj ; Mock, Andreas ; Oakes, Christopher C. ; Wang, Shihui ; Oppermann, Sina ; Lukas, Marina ; Kim, Vladislav ; Sill, Martin ; Benner, Axel ; Jauch, Anna ; Sutton, Lesley-Ann ; Young, Emma ; Rosenquist, Richard ; Liu, Xiyang ; Jethwa, Alexander ; Lee, Kwang Seok ; Lewis, Joe ; Putzker, Kerstin ; Lutz, Christoph ; Rossi, Davide ; Mokhir, Andriy ; Oellerich, Thomas ; Zirlik, Katja ; Herling, Marco ; Nguyen-Khac, Florence ; Plass, Christoph ; Andersson, Emma ; Mustjoki, Satu ; Kalle, Christof von ; Ho, Anthony Dick ; Hensel, Manfred ; Dürig, Jan ; Ringshausen, Ingo ; Zapatka, Marc ; Huber, Wolfgang ; Zenz, Thorsten
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer. Within chronic lymphocytic leukemia (CLL), responses to 62% of drugs were associated with 2 or more mutations, and linked the B cell receptor (BCR) pathway to trisomy 12, an important driver of CLL. Based on drug responses, the disease could be organized into phenotypic subgroups characterized by exploitable dependencies on BCR, mTOR, or MEK signaling and associated with mutations, gene expression, and DNA methylation. Fourteen percent of CLLs were driven by mTOR signaling in a non–BCR-dependent manner. Multivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation status and trisomy 12 as the most important modulators of response to kinase inhibitors in CLL. Ex vivo drug responses were associated with outcome. This study overcomes the perception that most mutations do not influence drug response of cancer, and points to an updated approach to understanding tumor biology, with implications for biomarker discovery and cancer care.
Howell, Kerry L. ; Davies, Jaime S. ; Allcock, Luise ; Braga-Henriques, Andreia ; Buhl-Mortensen, Pål ; Carreiro-Silva, Marina ; Dominguez-Carrió, Carlos ; Durden, Jennifer M. ; Foster, Nicola ; Game, Chloe A. ; Hitchin, Becky ; Horton, Tammy ; Hosking, Brett ; Jones, Daniel O. B. ; Mah, Christopher ; Laguionie Marchais, Claire ; Menot, Lenaick ; Morato, Telmo ; Pearman, Tabitha R. R. ; Piechaud, Nils ; Ross, Rebecca E. ; Ruhl, Henry A. ; Saeedi, Hanieh ; Stefanoudis, Paris V. ; Taranto, Gerald H. ; Thompson, Michael B. ; Taylor, James R. ; Tyler, Paul ; Vad, Johanne ; Victorero, Lissette ; Vieira, Rui P. ; Woodall, Lucy C. ; Xavier, Joana R. ; Wagner, Daniel
Video and image data are regularly used in the field of benthic ecology to document biodiversity. However, their use is subject to a number of challenges, principally the identification of taxa within the images without associated physical specimens. The challenge of applying traditional taxonomic keys to the identification of fauna from images has led to the development of personal, group, or institution level reference image catalogues of operational taxonomic units (OTUs) or morphospecies. Lack of standardisation among these reference catalogues has led to problems with observer bias and the inability to combine datasets across studies. In addition, lack of a common reference standard is stifling efforts in the application of artificial intelligence to taxon identification. Using the North Atlantic deep sea as a case study, we propose a database structure to facilitate standardisation of morphospecies image catalogues between research groups and support future use in multiple front-end applications. We also propose a framework for coordination of international efforts to develop reference guides for the identification of marine species from images. The proposed structure maps to the Darwin Core standard to allow integration with existing databases. We suggest a management framework where high-level taxonomic groups are curated by a regional team, consisting of both end users and taxonomic experts. We identify a mechanism by which overall quality of data within a common reference guide could be raised over the next decade. Finally, we discuss the role of a common reference standard in advancing marine ecology and supporting sustainable use of this ecosystem.