Refine
Year of publication
Document Type
- Preprint (680)
- Article (445)
- Bachelor Thesis (1)
- Book (1)
- Part of a Book (1)
- Conference Proceeding (1)
- Doctoral Thesis (1)
Has Fulltext
- yes (1130)
Is part of the Bibliography
- no (1130)
Keywords
- Heavy Ion Experiments (20)
- Hadron-Hadron Scattering (11)
- Hadron-Hadron scattering (experiments) (11)
- LHC (9)
- Heavy-ion collision (6)
- ALICE experiment (4)
- Collective Flow (4)
- Jets (4)
- Quark-Gluon Plasma (4)
- ALICE (3)
- Heavy Ions (3)
- Jets and Jet Substructure (3)
- pp collisions (3)
- ACL (2)
- Beauty production (2)
- COVID-19 (2)
- Cancer genomics (2)
- Charm physics (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- Germany (2)
- Heavy Quark Production (2)
- Lehre (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Particle Correlations and Fluctuations (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- QCD (2)
- Quality of life (2)
- Rehabilitation (2)
- Relativistic heavy-ion collisions (2)
- Shell model (2)
- Single electrons (2)
- 900 GeV (1)
- ALICE detector (1)
- ARDS (1)
- Adaptive control (1)
- Advanced biliary tract cancer (1)
- Africa (1)
- Afrika (1)
- Anti-nuclei (1)
- Atherosclerosis (1)
- Automatic (1)
- BRAF inhibitors (1)
- BTC (1)
- Back pain (1)
- Bevorratung (1)
- Biodiversity (1)
- Boosted Jets (1)
- COVID (1)
- Cancer (1)
- Cancer genetics (1)
- Canopy height model (1)
- Cardiac output (1)
- Cardiovascular diseases (1)
- Centrality Class (1)
- Centrality Selection (1)
- Charge fluctuations (1)
- Chemical company (1)
- Coase Theorem (1)
- Collective Flow, (1)
- Compact astrophysical objects (1)
- Comparison with QCD (1)
- Computational geometry (1)
- Conservative treatment (1)
- Costs (1)
- Covid-19 (1)
- Critical care (1)
- Cross-sectional study (1)
- Depression (1)
- Direct reactions (1)
- Disabling back pain (1)
- ETS (1)
- Echocardiography (1)
- Ecosystem services (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Elliptic flow (1)
- Epidural abscess (1)
- Epilepsy (1)
- Exercise (1)
- Experimental models of disease (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- First-line regimen (1)
- Forschung (1)
- Frankfurt <Main> / Universität (1)
- Function (1)
- Functional outcome (1)
- GVHD (1)
- Galaxies and clusters (1)
- Genomic instability (1)
- Guidelines (1)
- HBT (1)
- HIV (1)
- HNO (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hand-foot syndrome (1)
- Hard Scattering (1)
- Health information (1)
- Health risk analysis (1)
- Health-seeking behaviour (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Helpline (1)
- Hemodynamic management (1)
- Hif1α (1)
- High-energy astrophysics (1)
- High-energy neutron detection (1)
- Hochschuldidaktik (1)
- Human well-being (1)
- Inclusive spectra (1)
- Intensity interferometry (1)
- Invariant Mass Distribution (1)
- Inverse kinematics (1)
- Ionisation energy loss (1)
- Italy (1)
- Jet Physics (1)
- Jet Substructure (1)
- Joint Ownership (1)
- Kompetenzen (1)
- Lehrqualifikation (1)
- Line reconstruction (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- Material budget (1)
- Mediation (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Molecular medicine (1)
- Monte Carlo (1)
- Motor control (1)
- Multi-Parton Interactions (1)
- Multi-neutron detection (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Multinomial logistic regression (1)
- Myocardial infarction (1)
- NK cell (1)
- NK cell subset (1)
- Nature (1)
- Neural network (1)
- Noisy point clouds (1)
- Nuclear modification factor (1)
- Nuclear reactions (1)
- Nuclear structure & decays (1)
- Nucleon induced nuclear reactions (1)
- ORL (1)
- Occupational medicine (1)
- Oncology (1)
- Otorhinolaryngology (1)
- Outcome (1)
- PDGFRβ (1)
- PM (1)
- PYTHIA (1)
- Particle and Resonance Production (1)
- Pb–Pb (1)
- Personal- und Organisationsentwicklung (1)
- Pharmacodynamics (1)
- Physiotherapy (1)
- Plastic scintillator array (1)
- Post treatment (1)
- Prevalence (1)
- Prevention (1)
- Production Cross Section (1)
- Prognostic models (1)
- Properties of Hadrons (1)
- Property rights (1)
- Proton–proton (1)
- Public health (1)
- Pulse contour analysis (1)
- Pulse pressure variation (1)
- QGP (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Quarkonium (1)
- Quasi-free scattering (1)
- RTS (1)
- Rapidity Range (1)
- Rare diseases (1)
- Re-injury (1)
- Reactions with relativistic radioactive beams (1)
- Recurrence (1)
- Relational contracts (1)
- Relativistic heavy ion physics (1)
- Renegotiation (1)
- Research (1)
- Residency (1)
- Resolution Parameter (1)
- Return to play (1)
- Return to sports (1)
- SARS-CoV-2 (1)
- SARS-CoV‑2 pandemic (1)
- SARS-CoV‑2-Pandemie (1)
- SCT (1)
- Secondary prevention (1)
- Seizure (1)
- Single muons (1)
- Single-leg hop for distance (1)
- Sorafenib (1)
- Specialist training (1)
- Spectroscopic factors (1)
- Spectroscopic factors & electromagnetic moments (1)
- Stroke (1)
- Stroke volume variation (1)
- Studienstiftung des Deutschen Volkes (1)
- Surgery (1)
- Sweden (1)
- Systematic Uncertainty (1)
- TR (1)
- Target validation (1)
- Teaching (1)
- Telemedicine (1)
- Therapy (1)
- Thermodilution (1)
- Thrombosis (1)
- Time Projection Chamber (1)
- Tracking (1)
- Transition radiation detector (1)
- Transverse momentum (1)
- Treatment modification (1)
- Treatment protocol (1)
- Trigger (1)
- UAV (1)
- University hospitals (1)
- Universitätskliniken (1)
- VEGFR-2 (1)
- VEGFR-3 (1)
- Validity (1)
- Vector Boson Production (1)
- Vorratsschutz (1)
- Weiterbildung (1)
- Xenon-based gas mixture (1)
- accident (1)
- acupuncture (1)
- biological control (1)
- biologische Bekämpfung (1)
- c-kit (1)
- cART (1)
- cerebral sinus and vein thrombosis (CVT) (1)
- cigarillos (1)
- concurrent (1)
- dE/dx (1)
- decompressive craniectomy (1)
- detector (1)
- drone (1)
- exercise therapy (1)
- experimental results (1)
- faculty development (1)
- fine spatial resolution remote sensing (1)
- heavy ion experiments (1)
- higher education pedagogy (1)
- immune reconstitution (1)
- injury (1)
- intracerebral hemorrhage (ICH) (1)
- lockdown (1)
- medical training (1)
- metastasis-directed radiotherapy (1)
- organizational development (1)
- particulate matter (1)
- pediatric intensive care (1)
- plant height (1)
- quark gluon plasma (1)
- spectra (1)
- stereotactic (1)
- stored grain (1)
- stored product protection (1)
- structure-from-motion photogrammetry (1)
- targeted therapy (1)
- teach-the-teacher (1)
- teaching competencies (1)
- teaching skills (1)
- tension type headache (1)
- tobacco smoke (1)
- traditional Chinese medicine (1)
- trauma (1)
- tyrosine kinase inhibitors (1)
- vaccination (1)
- vaccine-induced immune thrombotic thrombocytopenia (VITT) (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (1079)
- Frankfurt Institute for Advanced Studies (FIAS) (956)
- Informatik (922)
- Medizin (32)
- ELEMENTS (5)
- Biowissenschaften (4)
- Senckenbergische Naturforschende Gesellschaft (4)
- Biodiversität und Klima Forschungszentrum (BiK-F) (3)
- Informatik und Mathematik (3)
- Institut für Ökologie, Evolution und Diversität (3)
Recent developments in medical education have created increasing challenges for medical teachers which is why the majority of German medical schools already offer educational and instructional skills trainings for their teaching staff. However, to date no framework for educational core competencies for medical teachers exists that might serve as guidance for the qualification of the teaching faculty. Against the background of the discussion about competency based medical education and based upon the international literature, the GMA Committee for Faculty and Organizational Development in Teaching developed a model of core teaching competencies for medical teachers. This framework is designed not only to provide guidance with regard to individual qualification profiles but also to support further advancement of the content, training formats and evaluation of faculty development initiatives and thus, to establish uniform quality criteria for such initiatives in German-speaking medical schools. The model comprises a framework of six competency fields, subdivided into competency components and learning objectives. Additional examples of their use in medical teaching scenarios illustrate and clarify each specific teaching competency. The model has been designed for routine application in medical schools and is thought to be complemented consecutively by additional competencies for teachers with special duties and responsibilities in a future step.
Die Entwicklungen in der Medizinischen Ausbildung der letzten Jahre konfrontieren Lehrende zunehmend mit neuen didaktischen Herausforderungen. An zahlreichen Standorten im deutschsprachigen Raum werden bereits Qualifizierungsangebote für Lehrende angeboten, jedoch fehlt bisher ein Orientierungsrahmen für medizindidaktische Kompetenzen, der ein Qualifikationsprofil für Lehrende darstellt.
Vor dem Hintergrund der Diskussion um die Kompetenzorientierung des Medizinstudiums und auf Grundlage aktueller internationaler Literatur wurde durch den GMA Ausschuss für Personal- und Organisationsentwicklung in der Lehre ein Kernkompetenzmodell für Lehrende in der Medizin entwickelt. Das Modell soll nicht nur den Lehrenden Orientierung zu ihrem Qualifikationsprofil geben, sondern auch die inhaltliche Ausrichtung hochschuldidaktischer (Aus-) Weiter- und Fortbildungen sowie die Evaluation von Fakultätsentwicklungsprozessen erleichtern und nicht zuletzt einheitliche Kriterien für die Beurteilung der Lehrqualifikation in deutschsprachigen Raum definieren.
Das Modell besteht aus sechs Kompetenzfeldern, für die jeweils Teilkompetenzen definiert und Lernziele beschrieben wurden. Anwendungsbeispiele sollen die jeweiligen Kompetenzen verdeutlichen.
Das Modell ist für die praktische Anwendung konzipiert und soll in einem nächsten Schritt durch spezifische Kompetenzen für Lehrende mit besonderen Aufgaben ergänzt werden.
The increasing use of targeted therapy (TT) has resulted in prolonged disease control and survival in many metastatic cancers. In parallel, stereotactic radiotherapy (SRT) is increasingly performed in patients receiving TT to obtain a durable control of resistant metastases, and thereby to prolong the time to disseminated disease progression and switch of systemic therapy. The aims of this study were to analyze the safety and efficacy of SRT combined with TT in metastatic cancer patients and to assess the influence of continuous vs. interrupted TT during metastasis-directed SRT. The data of 454 SRTs in 158 patients from the international multicenter database (TOaSTT) on metastatic cancer patients treated with SRT and concurrent TT (within 30 days) were analyzed using Kaplan–Meier and log rank testing. Toxicity was defined by the CTCAE v4.03 criteria. The median FU was 19.9 mo (range 1–102 mo); 1y OS, PFS and LC were 59%, 24% and 84%, respectively. Median TTS was 25.5 mo (95% CI 11–40). TT was started before SRT in 77% of patients. TT was interrupted during SRT in 44% of patients, with a median interruption of 7 (range 1–42) days. There was no significant difference in OS or PFS whether TT was temporarily interrupted during SRT or not. Any-grade acute and late SRT-related toxicity occurred in 63 (40%) and 52 (33%) patients, respectively. The highest toxicity rates were observed for the combination of SRT and EGFRi or BRAF/MEKi, and any-grade toxicity was significantly increased when EGFRi (p = 0.016) or BRAF/MEKi (p = 0.009) were continued during SRT. Severe (≥grade 3) acute and late SRT-related toxicity were observed in 5 (3%) and 7 (4%) patients, respectively, most frequently in patients treated with EGFRi or BRAF/MEKi and in the intracranial cohort. There was no significant difference in severe toxicity whether TT was interrupted before and after SRT or not. In conclusion, SRT and continuous vs. interrupted TT in metastatic cancer patients did not influence OS or PFS. Overall, severe toxicity of combined treatment was rare; a potentially increased toxicity after SRT and continuous treatment with EGFR inhibitors or BRAF(±MEK) inhibitors requires further evaluation.
The transverse mass mt distributions for deuterons and protons are measured in Pb+Pb reactions near midrapidity and in the range 0<mt–m<1.0 (1.5) GeV/c2 for minimum bias collisions at 158A GeV and for central collisions at 40 and 80 A GeV beam energies. The rapidity density dn/dy, inverse slope parameter T and mean transverse mass <mt> derived from mt distributions as well as the coalescence parameter B2 are studied as a function of the incident energy and the collision centrality. The deuteron mt spectra are significantly harder than those of protons, especially in central collisions. The coalescence factor B2 shows three systematic trends. First, it decreases strongly with increasing centrality reflecting an enlargement of the deuteron coalescence volume in central Pb+Pb collisions. Second, it increases with mt. Finally, B2 shows an increase with decreasing incident beam energy even within the SPS energy range. The results are discussed and compared to the predictions of models that include the collective expansion of the source created in Pb+Pb collisions.
Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter activity. Shown by pharmacological and siRNA-mediated inhibition, the observed effects are SIRT1-independent. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, a central post-transcriptional regulator of pro-inflammatory gene expression. Knockdown of KSRP expression prevented resveratrol-induced mRNA destabilization in human and murine cells. Resveratrol did not change KSRP expression, but immunoprecipitation experiments indicated that resveratrol reduces the p38 MAPK-related inhibitory KSRP threonine phosphorylation, without blocking p38 MAPK activation or activity. Mutation of the p38 MAPK target site in KSRP blocked the resveratrol effect on pro-inflammatory gene expression. In addition, resveratrol incubation enhanced KSRP-exosome interaction, which is important for mRNA degradation. Finally, resveratrol incubation enhanced its intra-cellular binding to the IL-8, iNOS and TNF-α mRNA. Therefore, modulation of KSRP mRNA binding activity and, thereby, enhancement of mRNA degradation seems to be the common denominator of many anti-inflammatory effects of resveratrol.
Objective: To investigate the feasibility, reliability, and validity of the Modified forward hop (MFH) test in participants after ACL reconstruction (ACLR).
Design: Reliability study.
Setting: Assessments were administered at different clinical locations in Germany and Switzerland by the same 2 investigators.
Participants: Forty-eight active individuals participated in this study (N=48).
Main Outcome Measures: The participants performed MFHs and Forward hops for distance in a predetermined order. The feasibility of the MFH was quantified with proportions of successfully executed attempts and Pearson's χ2 test. Its reliability was estimated using intraclass correlation coefficient (ICC) and standard error of measurement (SEM). Test validity was explored using Pearson's product moment correlation analyses.
Results: Fewer failed attempts were recorded among the participants (age: 30 [Standard deviation 11] years; 22 women, 26 (13) months post-surgery) when compared with the Forward hop for distance test (25/288 trials; 9% vs 72/288 trials; 25%). Within-session ICC values were excellent (>0.95) for both types of Forward hop tests, independent of the side examined. The SEM values were comparable between the Modified (injured: 5.6 cm, uninjured: 5.9 cm) and the classic Forward hop (injured: 4.3 cm, uninjured: 7.2 cm).
Conclusion: The MFH is a feasible, reliable, and valid tool for judging neuromuscular performance after ACLR. If the aim of a hop for distance incorporates enhanced perceived or real landing safety, landing on both feet should be used.
Background: Rare diseases are, by definition, very serious and chronic diseases with a high negative impact on quality of life. Approximately 350 million people worldwide live with rare diseases. The resulting high disease burden triggers health information search, but helpful, high-quality, and up-to-date information is often hard to find. Therefore, the improvement of health information provision has been integrated in many national plans for rare diseases, discussing the telephone as one access option. In this context, this study examines the need for a telephone service offering information for people affected by rare diseases, their relatives, and physicians.
Methods: In total, 107 individuals participated in a qualitative interview study conducted in Germany. Sixty-eight individuals suffering from a rare disease or related to somebody with rare diseases and 39 health care professionals took part. Individual interviews were conducted using a standardized semi-structured questionnaire. Interviews were analysed using the qualitative content analysis, triangulating patients, relatives, and health care professionals. The fulfilment of qualitative data processing standards has been controlled for.
Results: Out of 68 patients and relatives and 39 physicians, 52 and 18, respectively, advocated for the establishment of a rare diseases telephone service. Interviewees expected a helpline to include expert staffing, personal contact, good availability, low technical barriers, medical and psychosocial topics of counselling, guidance in reducing information chaos, and referrals. Health care professionals highlighted the importance of medical topics of counselling—in particular, differential diagnostics—and referrals.
Conclusions: Therefore, the need for a national rare diseases helpline was confirmed in this study. Due to limited financial resources, existing offers should be adapted in a stepwise procedure in accordance with the identified attributes.
Maize and rice constitute some of the most important cereals cultivated in the world, being used as staple food for people especially in Africa. The rice moth, Corcyra cephalonica, and the maize weevil, Sitophilus zeamais, are major pests of stored grains in the tropics. The use of parasitoids in biological pest control is already common in different agricultural and horticultural fields. At present, grain managers tend to look at alternatives to chemicals to control insects in stored grain. Lariophagus distinguendus (Förster) is a synovigenic, solitary larval and pupal ectoparasitoid of several beetle species that infest stored goods. The ability for long-range host finding of this parasitoid mediated by volatiles has been shown (Steidle & Schöller 1997). Habrobracon hebetor (Say) is a gregarious ectoparasitoid of many lepidopterous pests. This wasp occurs naturally in the stored grain ecosystem (Keever & al. 1985) where it attacks several pyralid moths, including the rice moth, Corcyra cephalonica. The present study was conducted to assess the host finding of the two parasitoids H. hebetor and L. distinguendus.
The proton drip-line nucleus 17Ne is investigated experimentally in order to determine its two-proton halo character. A fully exclusive measurement of the 17Ne(p, 2p)16F∗ →15O+p quasi-free one-proton knockout reaction has been performed at GSI at around 500 MeV/nucleon beam energy. All particles resulting from the scattering process have been detected. The relevant reconstructed quantities are the angles of the two protons scattered in quasi-elastic kinematics, the decay of 16F into 15O (including γ decays from excited states) and a proton, as well as the 15O+p relative-energy spectrum and the 16F momentum distributions. The latter two quantities allow an independent and consistent determination of the fractions of l = 0 and l = 2 motion of the valence protons in 17Ne. With a resulting relatively small l = 0 component of only around 35(3)%, it is concluded that 17Ne exhibits a rather modest halo character only. The quantitative agreement of the two values deduced from the energy spectrum and the momentum distributions supports the theoretical treatment of the calculation of momentum distributions after quasi-free knockout reactions at high energies by taking into account distortions based on the Glauber theory. Moreover, the experimental data allow the separation of valence-proton knockout and knockout from the 15O core. The latter process contributes with 11.8(3.1) mb around 40% to the total proton-knockout cross section of 30.3(2.3) mb, which explains previously reported contradicting conclusions derived from inclusive cross sections.
The evolution of the traditional nuclear magic numbers away from the valley of stability is an active field of research. Experimental efforts focus on providing key spectroscopic information that will shed light into the structure of exotic nuclei and understanding the driving mechanism behind the shell evolution. In this work, we investigate the spin-orbit shell gap towards the neutron dripline. To do so, we employed (p,2p) quasi-free scattering reactions to measure the proton component of the state of 16,18,20C. The experimental findings support the notion of a moderate reduction of the proton spin-orbit splitting, at variance to recent claims for a prevalent magic number towards the neutron dripline.