Refine
Year of publication
Document Type
- Contribution to a Periodical (474)
- Article (37)
- Review (10)
- Preprint (5)
- Conference Proceeding (1)
Has Fulltext
- yes (527) (remove)
Is part of the Bibliography
- no (527)
Keywords
- Angiogenesis (2)
- Wound healing (2)
- aging (2)
- 3years (1)
- ALK-rearranged NSCLC (1)
- Acute kidney injury (1)
- Antirheumatic agents (1)
- Blood loss (1)
- COVID-19 (1)
- CVD biomarker (1)
- Cardiac hypertrophy (1)
- Cardiology (1)
- Child (1)
- Cofactors (biochemistry) (1)
- Colloids (1)
- Comparative effectiveness research (1)
- Computational biology and bioinformatics (1)
- Consensus (1)
- Cytokines (1)
- DME (1)
- Dermatomyositis (1)
- Detergents (1)
- Diagnosis (1)
- EET (1)
- Ears (1)
- Endothelial progenitor cells (1)
- Epithelialization (1)
- Extended donor criteria (1)
- Graft function (1)
- Graft survival (1)
- HES (1)
- Heme (1)
- Hydroxyethyl starch (1)
- ILUVIEN (1)
- Inflammation (1)
- Ischemia (1)
- Liver transplantation (1)
- Marginal grafts (1)
- Membrane proteins (1)
- Metalloproteases (1)
- Organ rinse (1)
- Organ shortage (1)
- PC12 cells (1)
- Proteases (1)
- Protein structure (1)
- Proteolysis (1)
- RNA stem-loop structure (1)
- Retro-IDEAL (1)
- SARS-CoV-2 (1)
- SSTI (1)
- Steroid (1)
- TP53 mutation status (1)
- Tacrolimus (1)
- Trauma (1)
- Vasculogenesis (1)
- Volume therapy (1)
- acute infections (1)
- animal model (1)
- chronic infections (1)
- diabetes (1)
- diffusion model (1)
- ectosomes (1)
- exosomes (1)
- extracellular vesicles (1)
- fibrin-glue-spray technique (1)
- guidelines (1)
- inflammatory reaction (1)
- local antibiotics (1)
- microdosing (1)
- microparticles (1)
- microvesicles (1)
- minimal information requirements (1)
- mitochondria (1)
- neovascularization (1)
- neurodegeneration (1)
- neutralizing antibodies (1)
- paper-based assessment (1)
- prevention (1)
- processing speed (1)
- proliferation (1)
- reproducibility (1)
- rice bran extract (1)
- rigor (1)
- risk factor progression (1)
- risk factors (1)
- sequential ALK-inhibitor therapy (1)
- soft tissue (1)
- spike protein (1)
- standardization (1)
- tocopherol (1)
- tocotrienol (1)
- variants of concern (1)
- vitamin E (1)
- wound repair (1)
Institute
- Präsidium (496)
- Gesellschaftswissenschaften (42)
- Neuere Philologien (41)
- Medizin (29)
- Biowissenschaften (12)
- Erziehungswissenschaften (12)
- Universitätsbibliothek (11)
- Physik (10)
- Rechtswissenschaft (10)
- Wirtschaftswissenschaften (8)
Objective: Biologics have an important role in the treatment of juvenile idiopathic arthritis (JIA). Long‐term safety data are limited. Direct comparison of different agents regarding occurrence of adverse events (AEs), especially of rare events, requires large quantities of patient years. In this analysis, long‐term safety with regard to AE of special interest (AESI) was compared between different biologics.
Methods: Patients with nonsystemic JIA were selected from the German BIKER registry. Safety assessments were based on AE reports. Number of AEs, serious AEs, and 25 predefined AESIs, including medically important infection, uveitis, inflammatory bowel disease, cytopenia, hepatic events, anaphylaxis, depression, pregnancy, malignancy, and death, were analyzed. Event rates and relative risks were calculated using AEs reported after first dose through 70 days after last dose.
Results: A total of 3873 patients entered the analysis with 7467 years of exposure to biologics. The most common AESIs were uveitis (n = 231) and medically important infections (n = 101). Cytopenia and elevation of transaminases were more frequent with tocilizumab (risk ratio [RR] 8.0, 95% confidence interval [CI] 4.2‐15, and RR 4.7, 95% CI 1.8‐12.2, respectively). Anaphylactic events were associated with intravenous route of administration. In patients ever exposed to biologics, eight malignancies were reported. Six pregnancies have been documented in patients with tumor necrosis factor inhibitors. No death occurred in this patient cohort during observation.
Conclusion: Surveillance of pharmacotherapy as provided by the BIKER registry is an import approach, especially for long‐term treatment of children. Overall, tolerance was acceptable. Differences between biologics were noted and should be considered in daily patient care.
Streitpunkt Hochschulranking
(2012)
Seit den 90er Jahren werden auch in Deutschland Hochschulen und Fakultäten in Form von Rankings bewertet. Dabei werden anhand bestimmter Kriterien – z.B. Leistungen in Forschung und Lehre, Ausstattung oder Entwicklungsperspektiven – Ranglisten erstellt.
Hochschulrankings sind als Informationsquellen für Studierende, Wissenschaftler, Unternehmen und Hochschulpolitik immer wichtiger geworden. Zugleich schwelt seit einiger Zeit ein heftiger Streit über die generelle Aussagekraft von Rankings. Methodische Mängel und unzulässige Interpretationen der Daten seien zu beklagen, so die Kritiker. Einige Fakultäten und sogar ganze Hochschulen haben sich bereits aus bestimmten Rankings ausgeklinkt. Die Befürworter der Rankings wiederum sehen in diesen Austritten eine Gefahr für die Wettbewerbsfähigkeit der deutschen Hochschulen.
Wir haben speziell zu einem der wichtigsten Rankings zwei Standpunkte eingeholt. Frank Ziegele, Geschäftsführer des Centrum für Hochschulentwicklung (CHE), verteidigt das CHE Hochschulranking, Prof. Sighard Neckel, Soziologe an der Goethe-Universität, kontert mit seiner Kritik.
Two-particle correlation functions of negative hadrons over wide phase space, and transverse mass spectra of negative hadrons and deuterons near mid-rapidity have been measured in central Pb+Pb collisions at 158 GeV per nucleon by the NA49 experiment at the CERN SPS. A novel Coulomb correction procedure for the negative two-particle correlations is employed making use of the measured oppositely charged particle correlation. Within an expanding source scenario these results are used to extract the dynamic characteristics of the hadronic source, resolving the ambiguities between the temperature and transverse expansion velocity of the source, that are unavoidable when single and two particle spectra are analysed separately. The source shape, the total duration of the source expansion, the duration of particle emission, the freeze-out temperature and the longitudinal and transverse expansion velocities are deduced.
We report measurements of Xi and Xi-bar hyperon absolute yields as a function of rapidity in 158 GeV/c Pb+Pb collisions. At midrapidity, dN/dy = 2.29 +/- 0.12 for Xi, and 0.52 +/- 0.05 for Xi-bar, leading to the ratio of Xi-bar/Xi = 0.23 +/- 0.03. Inverse slope parameters fitted to the measured transverse mass spectra are of the order of 300 MeV near mid-rapidity. The estimated total yield of Xi particles in Pb+Pb central interactions amounts to 7.4 +/- 1.0 per collision. Comparison to Xi production in properly scaled p+p reactions at the same energy reveals a dramatic enhancement (about one order of magnitude) of Xi production in Pb+Pb central collisions over elementary hadron interactions.
The directed and elliptic flow of protons and charged pions has been observed from the semi-central collisions of a 158 GeV/nucleon Pb beam with a Pb target. The rapidity and transverse momentum dependence of the flow has been measured. The directed flow of the pions is opposite to that of the protons but both exhibit negative flow at low pt. The elliptic flow of both is fairly independent of rapidity but rises with pt. PACS numbers: 25.75.-q, 25.75.Ld
Using the NA49 main TPC, the central production of hyperons has been measured in CERN SPS Pb - Pb collisions at 158 GeV c-1. The preliminary ratio, studied at 2.0 < y < 2.6 and 1 < pT < 3 GeV c-1, equals ~ (13 ± 4)% (systematic error only). It is compatible, within errors, with the previously obtained ratios for central S + S [1], S + W [2], and S + Au [3] collisions. The fit to the transverse momentum distribution resulted in an inverse slope parameter T of 297 MeV. At this level of statistics we do not see any noticeable enhancement of hyperon production with the increased volume (and, possibly, degree of equilibration) of the system from S + S to Pb + Pb. This result is unexpected and counterintuitive, and should be further investigated. If confirmed, it will have a significant impact on our understanding of mechanisms leading to the enhanced strangeness production in heavy-ion collisions.
Preliminary data on phi production in central Pb + Pb collisions at 158 GeV per nucleon are presented, measured by the NA49 experiment in the hadronic decay channel phi - K+K-. At mid-rapidity, the kaons were separated from pions and protons by combining dE/dx and time-of-flight information; in the forward rapidity range only dE/dx identification was used to obtain the rapidity distribution and a rapidity-integrated mt-spectrum. The mid-rapidity yield obtained was dN/dy = 1.85 ± 0.3 per event; the total phi multiplicity was estimated to be 5.0 ± 0.7 per event. Comparison with published pp data shows a slight, but not very significant strangeness enhancement.
The large acceptance TPCs of the NA49 spectrometer allow for a systematic multidimensional study of two-particle correlations in different part of phase space. Results from Bertsch-Pratt and Yano-Koonin-Podgoretskii parametrizations are presented differentially in transverse pair momentum and pair rapidity. These studies give an insight into the dynamical space-time evolution of relativistic Pb+Pb collisions, which is dominated by longitudinal expansion.
Lambda and Antilambda reconstruction in central Pb+Pb collisions using a time projection chamber
(1997)
The large acceptance time projection chambers of the NA49 experiment are used to record the trajectory of charged particles from Pb + Pb collisions at 158 GeV per nucleon. Neutral strange hadrons have been reconstructed from their charged decay products. To obtain distributions of Λ, and Ks0 in discrete bins of rapidity, y, and transverse momentum, pT, calculations have been performed to determine the acceptance of the detector and the efficiency of the reconstruction software as a function of both variables. The lifetime distributions obtained give values of cτ = 7.8 ± 0.6 cm for Λ and cτ = 2.5 ± 0.3 cm for Ks0, consistent with data book values.
Background: Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and a major cause of morbidity among children with pediatric rheumatic diseases. The management of JDM is very heterogeneous. The JDM working group of the Society for Pediatric Rheumatology (GKJR) aims to define consensus- and practice-based strategies in order to harmonize diagnosis, treatment and monitoring of JDM.
Methods: The JDM working group was established in 2015 consisting of 23 pediatric rheumatologists, pediatric neurologists and dermatologists with expertise in the management of JDM. Current practice patterns of management in JDM had previously been identified via an online survey among pediatric rheumatologists and neurologists. Using a consensus process consisting of online surveys and a face-to-face consensus conference statements were defined regarding the diagnosis, treatment and monitoring of JDM. During the conference consensus was achieved via nominal group technique. Voting took place using an electronic audience response system, and at least 80% consensus was required for individual statements.
Results: Overall 10 individual statements were developed, finally reaching a consensus of 92 to 100% regarding (1) establishing a diagnosis, (2) case definitions for the application of the strategies (moderate and severe JDM), (3) initial diagnostic testing, (4) monitoring and documentation, (5) treatment targets within the context of a treat-to-target strategy, (6) supportive therapies, (7) explicit definition of a treat-to-target strategy, (8) various glucocorticoid regimens, including intermittent intravenous methylprednisolone pulse and high-dose oral glucocorticoid therapies with tapering, (9) initial glucocorticoid-sparing therapy and (10) management of refractory disease.
Conclusion: Using a consensus process among JDM experts, statements regarding the management of JDM were defined. These statements and the strategies aid in the management of patients with moderate and severe JDM.
Vom 19. bis 21. September fand im Forschungskolleg Humanwissenschaften die bereits dritte Bad Homburg Conference statt. Die Konferenz zum Thema Künstliche Intelligenz brachte Perspektiven aus verschiedenen wissenschaftlichen Disziplinen und der Praxis zusammen. Referentinnen und Referenten u. a. aus Informatik, Rechtswissenschaft, Medizin, Philosophie und Hirnforschung diskutierten mit Vertretern der gesellschaftlichen Praxis: Unternehmern, Industrievertretern, einem Kriminalhauptkommissar des Landeskriminalamts Hessen und einer Bürgerrechtsaktivistin und Politikberaterin aus den USA. Begrüßt wurden die Teilnehmer von ForschungskollegDirektor Prof. Dr. Matthias Lutz-Bachmann, der Vizepräsidentin der Goethe-Universität, Prof. Dr. Simone Fulda, dem Bürgermeister der Stadt Bad Homburg, Meinhard Matern, sowie der Hessischen Ministerin für Digitale Strategie und Entwicklung, Prof. Dr. Kristina Sinemus. Der Abschlusskommentar kam von Christoph Burchard, Professor für Straf- und Strafprozessrecht, Internationales und Europäisches Strafrecht, Rechtsvergleichung und Rechtstheorie an der Goethe-Universität. Der UniReport hatte Gelegenheit, mit Christoph Burchard nach der Konferenz zu sprechen.
Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic macular edema (DME) in clinical practices in Germany.
Methods: This study was conducted across 16 sites in Germany and involved 81 eyes (63 patients) with persistent or recurrent DME and a prior suboptimal response to a first-line intravitreal therapy (primarily anti-VEGF intravitreal therapies).
Results: Patients were followed-up for 30.8 ± 11.3 months (mean ± standard deviation) and had a mean age of 68.0 ± 10.4 years. Best-recorded visual acuity (BRVA) improved by +5.5 letters at month 9 (P ⩽ 0.005, n=56; from a baseline of 49 letters) and this was maintained through to month 30 (P ⩽ 0.05, n = 42). There was a concurrent improvement in central macular thickness with a reduction from 502 µm at baseline to 338 µm at year 1 (P ⩽ 0.0001, n = 43). This effect was sustained to year 3 (i.e. 318 µm; P ⩽ 0.0001, n = 29). Mean intraocular pressure (IOP) remained constant between baseline and year 3 with a peak change of 1.9 mm Hg occurring at year 1. Elevated IOP was observed in a similar percentage of patients prior to (22.2% of cases) and following (27.2%) treatment with the FAc implant. In the majority of cases, these elevations were managed effectively with IOP medications.
Conclusions: Despite substantial amounts of prior intravitreal treatments – primarily with anti–vascular endothelial growth factor (VEGF) drugs – this real-world study showed that sustained structural and functional improvements can last for up to 3 years with a single FAc implant.
In his widely acclaimed book “Das Kalte Herz” (The Cold Heart), economic historian Werner Plumpe tells the story of the history of capitalism, which in his view represents a sober form of economics which has proved itself superior and higher performing than other systems. To this day, the long tradition of capitalism criticism has not understood that in capitalism, great wealth is utilized to produce goods that are usually affordable for people with small incomes.