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Noh, S. ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Osako, Takumi ; Oskarsson, Anders Nils Erik ; Otwinowski, Jacek Tomasz ; Oya, Motomi ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paić, Guy ; Palasciano, Antonio ; Panebianco, Stefano Matthias ; Park, Jonghan ; Parkkila, Jasper Elias ; Pathak, Surya Prakash ; Patra, Rajendra Nath ; Paul, Biswarup ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pereira, Luis Gustavo ; Pereira da Costa, Hugo Denis Antonio ; Peresunko, Dmitry Yurevich ; Mesa Perez, Guillermo ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrov, Viacheslav ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polichtchouk, Boris ; Politano, S. ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf-Houssais, Sarah Julie ; Porter, Jeffrey Brent ; Pozdniakov, Valeriy ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Qiu, Shi ; Quaglia, Luca ; Quishpe, Raquel Estefania ; Ragoni, Simone ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Rodríguez Ramírez, Saúl Aníbal ; Rancien, Thibaut Albert ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Rath, Rutuparna ; Ravasenga, Ivan ; Read, Kenneth Francis ; Redelbach, Andreas Ralph ; Redlich, Krzysztof ; Rehman, Attiq ur ; Reichelt, Patrick ; Reidt, Felix ; Reme-Ness, Haakon André ; Rescakova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor G. ; Richert, Tuva Ora Herenui ; Richter, Matthias Rudolph ; 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Yamakawa, Kosei ; Yang, S. ; Yano, Satoshi ; Yin, Zhongbao ; Yoo, In-Kwon ; Yoon, Jin-Hee ; Yuan, S. ; Yüncü, Alperen ; Zaccolo, Valentina ; Zampolli, Chiara ; Correia Zanoli, Henrique Jose ; Zanone, Federica ; Zardoshti, Nima ; Zarochentsev, Andrey ; Závada, Petr ; Zaviyalov, Nikolaj ; Zhalov, Mikhail ; Zhang, B. ; Zhang, S. ; Zhang, Xiaoming ; Zhang, Y. ; Zherebchevskii, Vladimir ; Zhi, Y. ; Zhigareva, Natalia ; Zhou, Daicui ; Zhou, You ; Zhu, Jianhui ; Zhu, Y. ; Zinovjev, Gennady M. ; Zurlo, Nicola
We present the first measurement of event-by-event fluctuations in the kaon sector in Pb – Pb collisions at √sNN = 2.76 TeV with the ALICE detector at the LHC. The robust fluctuation correlator νdyn is used to evaluate the magnitude of fluctuations of the relative yields of neutral and charged kaons, as well as the relative yields of charged kaons, as a function of collision centrality and selected kinematic ranges. While the correlator νdyn[K+,K−] exhibits a scaling approximately in inverse proportion of the charged particle multiplicity, νdyn[K0 S ,K±] features a significant deviation from such scaling. Within uncertainties, the value of νdyn[K0 S ,K±] is independent of the selected transverse momentum interval, while it exhibits a pseudorapidity dependence. The results are compared with HIJING, AMPT and EPOS–LHC predictions, and are further discussed in the context of the possible production of disoriented chiral condensates in central Pb – Pb collisions.
Radon adsorption in charcoal
(2021)
Maier, Andreas ; Jones, Jesse ; Sternkopf, Sonja ; Friedrich, Erik ; Fournier, Claudia ; Kraft, Gerhard
Radon is pervasive in our environment and the second leading cause of lung cancer induction after smoking. Therefore, the measurement of radon activity concentrations in homes is important. The use of charcoal is an easy and cost-efficient method for this purpose, as radon can bind to charcoal via Van der Waals interaction. Admittedly, there are potential influencing factors during exposure that can distort the results and need to be investigated. Consequently, charcoal was exposed in a radon chamber at different parameters. Afterward, the activity of the radon decay products 214Pb and 214Bi was measured and extrapolated to the initial radon activity in the sample. After an exposure of 1 h, around 94% of the maximum value was attained and used as a limit for the subsequent exposure time. Charcoal was exposed at differing humidity ranging from 5 to 94%, but no influence on radon adsorption could be detected. If the samples were not sealed after exposure, radon desorbed with an effective half-life of around 31 h. There is also a strong dependence of radon uptake on the chemical structure of the recipient material, which is interesting for biological materials or diffusion barriers as this determines accumulation and transport.
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P. ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein, Spencer Robert ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Knospe, Anders Garritt ; Kobdaj, Chinorat ; Köhler, Markus Konrad ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia ; Kondratyuk, Evgeny ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Koryciak, Sebastian Dominik ; Koska, Lukáš ; Kotliarov, A. ; Kovalenko, Oleksandr ; Kovalenko, Vladimir ; Kowalski, Marek ; Králik, Ivan ; Kravˇcakova, A. ; Kreis, Lukas ; Krivda, Marian ; Krizek, Filip ; Krizkova Gajdosova, Katarina ; Kroesen, Martin ; Kruger, Mario ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kuˇcera, V. ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kumaoka, T. ; Kumar, D. ; Kumar, Lokesh ; Kumar, N. ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kvapil, Jakub ; Kweon, Min Jung ; Kwon, J. Y. ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lai, Yue Shi ; Lakrathok, Anantachai ; Lamanna, Massimo ; Langoy, Rune ; Lapidus, Kirill ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Lavicka, Roman ; Lazareva, Tatiana V. ; Lea, Ramona ; Lehrbach, Johannes ; Lemmon, Roy Crawford ; Leon Monzon, Ildefonso ; Lesser, Ezra Douglas ; Lettrich, Michael ; Lévai, Péter ; Li, X. ; Li, Xing Long ; Lien, Jørgen André ; Lietava, Roman ; Lim, Bong-Hwi ; Lim, S. H. ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Liu, Alwina Ruixin ; Liu, J. ; Lofnes, I. M. ; Loginov, Vitaly ; Loizides, Constantinos ; Lončar, Petra ; López, Jorge Andres ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Luhder, Jens Robert ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Maevskaya, Alla ; Mager, Magnus ; Mahmoud, Tariq ; Maire, Antonin ; Malaev, Mikhail ; Malik, Nasir Mehdi ; Malik, Qasim Waheed ; Malinina, Liudmila ; Mal’Kevich, Dmitry ; Mallick, Neelkamal ; Malzacher, Peter ; Mandaglio, Giuseppe ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marin, Ana ; Markert, Christina ; Marquard, Marco ; Martin, Nicole Alice ; Martinengo, Paolo ; Martinez, Jacobb Lee ; Martínez Hernández, Mario Iván ; García Martínez, Ginés ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Mathis, Andreas Michael ; Matonoha, Oliver ; Matuoka, Paula Fernanda Toledo ; Matyja, Adam Tomasz ; Mayer, Christoph ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Mazzoni, Alessandra Maria ; Mdhluli, J. E. ; Mechler, Adrian Florin ; Meddi, Franco ; Melikyan, Yury ; Menchaca-Rocha, Arturo Alejandro ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Meres, Michal ; Mhlanga, Sibaliso ; Miake, Yasuo ; Micheletti, Luca ; Migliorin, Lucrezia Camilla ; Mihaylov, Dimitar Lubomirov ; Mikhaylov, Konstantin ; Mishra, Aditya Nath ; Mi´skowiec, D. ; Modak, Abhi ; Mohanty, Auro Prasad ; Mohanty, Bedangadas ; Khan, M. Mohisin ; Moravcova, Zuzana ; Mordasini, Cindy ; Godoy, Denise Aparecida Moreira de ; Perez Moreno, Luis Alberto ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Mudnic, Eugen ; Muhlheim, Daniel ; Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Munhoz, Marcelo Gameiro ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nair, Rahul Ramachandran ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Naru, Muhammad Umair ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Neagu, Alexandra ; Nellen, Lukas ; Nesbo, Simon Voigt ; Nešković, Gvozden ; Nesterov, Dmitrii ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, S. ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Osako, Takumi ; Oskarsson, Anders Nils Erik ; Otwinowski, Jacek Tomasz ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Pai´c, G. ; Palasciano, Antonio ; Pan, Jinjin ; Panebianco, Stefano Matthias ; Pareek, Pooja ; Park, Jonghan ; Parkkila, Jasper Elias ; Pathak, Surya Prakash ; Patra, Rajendra Nath ; Paul, Biswarup ; Pazzini, J. ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pereira, Luis Gustavo ; Pereira da Costa, Hugo Denis Antonio ; Peresunko, Dmitry Yurevich ; Perez, G. M. ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polichtchouk, Boris ; Politano, S. ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf-Houssais, Sarah Julie ; Porter, Jeffrey Brent ; Pozdniakov, Valeriy ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Qiu, S. ; Quaglia, Luca ; Quishpe, Raquel Estefania ; Ragoni, Simone ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Rodríguez Ramírez, Saúl Aníbal ; Torres Ramos, Arianna Grisel ; Rancien, Thibaut Albert ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Rath, Rutuparna ; Ravasenga, Ivan ; Read, Kenneth Francis ; Redelbach, Andreas Ralph ; Redlich, Krzysztof ; Rehman, Attiq ur ; Reichelt, Patrick ; Reidt, Felix ; Reme-Ness, Haakon André ; Renfordt, Rainer Arno Ernst ; Rescakova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor G. ; Richert, Tuva Ora Herenui ; Richter, Matthias Rudolph ; Riegler, Werner ; Riggi, Francesco ; Ristea, Cătălin-Lucian ; Rode, Sudhir Pandurang ; Rodrı́guez Cahuantzi, Mario ; Røed, Ketil ; Rogalev, Roman ; Rogochaya, Elena ; Rogoschinski, Tim Sebastian ; Rohr, David ; Röhrich, Dieter ; Fierro Rojas, Pablo ; Rokita, Przemyslaw Stefan ; Ronchetti, Federico ; Rosano, Antonina ; Dominguez Rosas, Edgar ; Rossi, Andrea ; Rotondi, Alberto ; Roy, Ankhi ; Roy, Pradip Kumar ; Roy, S. ; Rubini, Nicola ; Vazquez Rueda, Omar ; Rui, Rinaldo ; Rumyantsev, Boris ; Russek, P. G. ; Rustamov, Anar ; Ryabinkin, Evgeny ; Ryabov, Yury ; Rybicki, Andrzej ; Rytkönen, Heidi Maria ; Rzęsa, Wioleta ; Saarimäki, Oskari Antti Matti ; Sadek, Rita ; Sadovskiy, Sergey ; Sætre, Jon-are ; Šafařík, Karel ; Saha, S. K. ; Saha, S. ; Sahoo, Baidyanath ; Sahoo, Pragati ; Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Dushmanta ; Sahu, Pradip Kumar ; Saini, Jogender ; Sakai, Shingo ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Sarkar, Debojit ; Sarkar, Nachiketa ; Sarma, Pranjal ; Mantovani Sarti, Valentina ; Sas, Mike Henry Petrus ; Schambach, Joachim ; Scheid, Horst Sebastian ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmah, Alexander ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schmidt, Marten Ole ; Schmidt, M. ; Schmidt, Nicolas ; Schmier, Austin Robert ; Schotter, Romain ; Schukraft, Jürgen ; Schutz, Yves Roland ; Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Seger, Janet Elizabeth ; Sekiguchi, Yuko ; Sekihata, Daiki ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Seo, Jin Joo ; Serebryakov, Dmitry ; Šerkšnytė, Laura ; Sevcenco, Adrian ; Shaba, Tebogo Joyce ; Shabanov, Arseniy ; Shabetai, Alexandre ; Shahoyan, Ruben ; Shaikh, Wadut ; Shangaraev, Artem ; Sharma, A. ; Sharma, H. ; Sharma, M. ; Sharma, Natasha ; Sharma, S. ; Sharma, U. ; Sheibani, Oveis ; Shigaki, Kenta ; Shimomura, Maya ; Shirinkin, Sergey ; Shou, Qiye ; Sibiriak, Yury ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Silva, Tiago Fiorini da ; Silvermyr, David Olle Rickard ; Simonetti, Giuseppe ; Singh, B. ; Singh, R. ; Singh, R. ; Singh, R. ; Singh, V. 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In particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD)1. These partons subsequently emit further partons in a process that can be described as a parton shower2, which culminates in the formation of detectable hadrons. Studying the pattern of the parton shower is one of the key experimental tools for testing QCD. This pattern is expected to depend on the mass of the initiating parton, through a phenomenon known as the dead-cone effect, which predicts a suppression of the gluon spectrum emitted by a heavy quark of mass mQ and energy E, within a cone of angular size mQ/E around the emitter3. Previously, a direct observation of the dead-cone effect in QCD had not been possible, owing to the challenge of reconstructing the cascading quarks and gluons from the experimentally accessible hadrons. We report the direct observation of the QCD dead cone by using new iterative declustering techniques4,5 to reconstruct the parton shower of charm quarks. This result confirms a fundamental feature of QCD. Furthermore, the measurement of a dead-cone angle constitutes a direct experimental observation of the non-zero mass of the charm quark, which is a fundamental constant in the standard model of particle physics.
Müller, Volkmar ; Wöckel, Achim ; Lux, Michael Patrick ; Janni, Wolfgang ; Hartkopf, Andreas ; Nabieva, Naiba ; Ţăran, Florin-Andrei ; Hadji, Hans ; Ettl, Johannes ; Lüftner, Diana ; Welslau, Manfred ; Belleville, Erik ; Brucker, Sara ; Schütz, Florian ; Fasching, Peter Andreas ; Fehm, Tanja ; Kolberg, Hans-Christian ; Schneeweiss, Andreas ; Overkamp, Friedrich
Neue Therapieentwicklungen zur Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom konzentrieren sich zurzeit sowohl auf die Identifikation von Patientinnen für zielgerichtete Therapieansätze als auch auf die Weiterentwicklung von immuntherapeutischen Ansätzen. Die Datenlage zu den CDK4/6-Inhibitoren konnte vervollständigt werden und ist konsistent in dieser Klasse von Substanzen (Palbociclib, Ribociclib und Abemaciclib). Weitere Signalwege, die untersucht werden, sind der PI3K-und der AKT-Signalweg sowie verschiedene Ansatzpunkte zu deren Hemmung. Für beide Wirkmechanismen liegen auch erste Studienergebnisse vor, die vor Kurzem vorgestellt wurden. Außerdem wachsen die Erkenntnisse zu den PARP-Inhibitoren, für die auch untersucht wird, in welcher Population sie am effektivsten eingesetzt werden können. Dieser Review-Artikel soll die aktuellen Studien zusammenfassen und einen Ausblick der neuesten Entwicklungen geben.
Müller, Volkmar ; Wöckel, Achim ; Lux, Michael Patrick ; Janni, Wolfgang ; Hartkopf, Andreas ; Nabieva, Naiba ; Ţăran, Florin-Andrei ; Hadji, Hans ; Ettl, Johannes ; Lüftner, Diana ; Welslau, Manfred ; Belleville, Erik ; Brucker, Sara ; Schütz, Florian ; Fasching, Peter Andreas ; Fehm, Tanja ; Kolberg, Hans-Christian ; Schneeweiss, Andreas ; Overkamp, Friedrich
New therapeutic developments aimed at treating women with advanced breast cancer currently focus both on identifying patients eligible for targeted therapeutic concepts and on the continuing development of immune therapies. The data on CDK4/6 inhibitors are now complete and consistent in this class of substances (palbociclib, ribociclib and abemaciclib). Further pathways under investigation are PI3K and AKT signalling pathways along with diverse approaches to their inhibition. Initial study results were also presented recently on both mechanisms of action. Insights into the PARP inhibitors, moreover, are increasing; studies in this respect are also examining in which population they can be used most effectively. This review offers a summary of the recent studies and an outline of the latest developments.
Acharya, Shreyasi ; Adamová, Dagmar ; Adler, Alexander ; Adolfsson, Jonatan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akbar, Zaenal ; Akindinov, Alexander ; Al-Turany, Mohammad ; Alam, Sk Noor ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Ali, Yasir ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altenkämper, Lucas ; Altsybeev, Igor ; Anaam, Mustafa ; Andrei, Cristian ; Andreou, Dimitra ; Andronic, Anton ; Angeletti, Massimo ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Chandra, Anuj ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Arnaldi, Roberta ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Aziz, Sizar ; Azmi, Mohd Danish ; Badalà, Angela ; Baek, Yong Wook ; Bai, Xiaozhi ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Bala, Renu ; Balbino, Alessandro ; Baldisseri, Alberto ; Balis, Bartosz ; Ball, Markus ; Banerjee, Debjani ; Barbera, Roberto ; Barioglio, Luca ; Barlou, Maria ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Ramillien Barret, Valerie ; Bartels, Clara ; Barth, Klaus ; Bartsch, Esther ; Baruffaldi, Filippo ; Bastid, Nicole ; Basu, Sumit ; Batigne, Guillaume ; Batyunya, Boris ; Bauri, Dibakar ; Bazo Alba, José Luis ; Bearden, Ian Gardner ; Beattie, Caitlin ; Belikov, Iouri ; Bell Hechavarria, Ailec de la Caridad ; Bellini, Francesca ; Bellwied, Rene ; Belokurova, Svetlana ; Belyaev, Vladimir ; Bencédi, Gyula ; Beolè, Stefania ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berdnikova, Anastasia ; Berényi, Dániel ; Bergmann, Luisa ; Besoiu, Mihaela Gabriela ; Betev, Latchezar ; Bhaduri, Partha Pratim ; Bhasin, Anju ; Bhat, Inayat Rasool ; Bhat, Mohammad Asif ; Bhattacharjee, Buddhadeb ; Bhattacharya, Purba ; Bianchi, Livio ; Bianchi, Nicola ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biernat, Jacek ; Bilandzic, Ante ; Biro, Gabor ; Biswas, Saikat ; Blair, Justin Thomas ; Blau, Dmitry S. ; Blidaru, Mihail-Bogdan ; Blume, Christoph ; Boca, Gianluigi ; Bock, Friederike ; Bogdanov, Alexey A. ; Boi, Stefano ; Bok, Jeongsu ; Boldizsar, László ; Bolozdynya, Alexander I. ; Bombara, Marek ; Bond, Peter Matthew ; Bonomi, Germano ; Borel, Hervé ; Borissov, Alexander ; Bossi, Hannah ; Botta, Elena ; Bratrud, Lars ; Braun-Munzinger, Peter ; Bregant, Marco ; Broz, Michal ; Bruno, Giuseppe Eugenio ; Buckland, Matthew Daniel ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bugnon, Ophélie ; Bühler, Paul ; Buthelezi, Edith Zinhle ; Bashir Butt, Jamila ; Bysiak, Sebastian Adam ; Caffarri, Davide ; Cai, Mengke ; Caines, Helen Louise ; Caliva, Alberto ; Calvo Villar, Ernesto ; Mejia Camacho, Juan Manuel ; Soto Camacho, Rabi ; Camerini, Paolo ; Canedo, Fabio de Moraes Canedo ; Carnesecchi, Francesca ; Caron, Robin Albert Andre ; Castillo Castellanos, Javier Ernesto ; Casula, Ester Anna Rita ; Catalano, Fabio ; Ceballos Sanchez, Cesar ; Chakraborty, Pritam ; Chandra, Sinjini ; Chapeland, Sylvain ; Chartier, Marielle ; Chattopadhyay, Subhasis ; Chattopadhyay, Sukalyan ; Chauvin, Alex Henri Jean ; García Chávez, Tonatiuh ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Cho, Soyeon ; Chochula, Peter ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Ciupek, Michael Rudolf ; Clai, Giulia ; Cleymans, Jean Willy Andre ; Colamaria, Fabio Filippo ; Colburn, Jonathan Samuel ; Colella, Domenico ; Collu, Alberto ; Colocci, Manuel ; Concas, Matteo ; Conesa Balbastre, Gustavo ; Conesa Del Valle, Zaida ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Coquet, Maurice Louis ; Cormier, Thomas Michael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Costanza, Susanna ; Crochet, Philippe ; Cuautle Flores, Eleazar ; Cui, Pengyao ; Cunqueiro Mendez, Leticia ; Dainese, Andrea ; Damas, Florian Paul André ; Danisch, Meike Charlotte ; Danu, Andrea ; Das, Indranil ; Das, Prottay ; Das, Prottoy ; Das, Supriya ; Dash, Sadhana ; De, Sudipan ; De Caro, Annalisa ; De Cataldo, Giacinto ; De Cilladi, Lorenzo ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, Suman ; Franz Degenhardt, Hermann ; Deja, Kamil Rafal ; Dello Stritto, Luigi ; Delsanto, Silvia ; Deng, Wenjing ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Arteche Diaz, Raul ; Dietel, Thomas ; Ding, Yanchun ; Divià, Roberto ; Dixit, Dhruv Utpalkumar ; Djuvsland, Øystein ; Dmitrieva, Uliana ; Do, Jaehyeon ; Dobrin, Alexandru Florin ; Donigus, Benjamin ; Dordic, Olja ; Dubey, Anand Kumar ; Dubla, Andrea ; Dudi, Sandeep ; Mallick, Dukhishyam ; Dupieux, Pascal ; Dzalaiova, Natalia ; Eder, Tabea Maria ; Ehlers Iii, Raymond James ; Eikeland, Viljar Nilsen ; Eisenhut, Florian ; Elia, Domenico ; Erazmus, Barbara Ewa ; Ercolessi, Francesca ; Erhardt, Filip ; Erokhin, Andrey ; Ersdal, Magnus Rentsch ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fantoni, Alessandra ; Fasel, Markus ; Fecchio, Pietro ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrero, Andrea ; Ferretti, Alessandro ; Feuillard, Victor Jose Gaston ; Figiel, Jan ; Filchagin, Sergey ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiorenza, Gabriele ; Flor, Fernando Antonio ; Flores, Amanda Nicole ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Frajna, Eszter ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Gaardhoeje, Jens Joergen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gal, Arthur Willem Jean ; Duarte Galvan, Carlos ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Alvarado Garcia, Jesús Ricardo ; Garcia-Solis, Edmundo Javier ; Garg, Kunal ; Gargiulo, Corrado ; Garibli, Aydan ; Garner, Katharina ; Demmich, Katharina ; Gasik, Piotr ; Gauger, Erin Frances ; Gautam, Amrit ; Ducati, Maria Beatriz de Leone Gay ; Ducati, Maria Beatriz de Leone Gay ; Germain, Marie ; Ghosh, Jhuma ; Ghosh, Premomoy ; Ghosh, Sanjay Kumar ; Giacalone, Marco ; Gianotti, Paola ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Goh, Daniel Jia Qin ; Gonzalez, Victor ; González Trueba, Laura Helena ; Gorbunov, Sergey ; Gorgon, Marek Boguslaw ; Görlich, Lidia Maria ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Greiner, Leo Clifford ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Ara ; Grigoryan, Smbat ; Groettvik, Ola Slettevoll ; Grosa, Fabrizio ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Garcia Guardiano, Gabriel ; Guernane, Rachid ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Bautista Guzman, Irais ; Paisano Guzman, Sergio ; Gyulai, Laszlo ; Habib, Michael Karim ; Hadjidakis, Cynthia Marie ; Halimoglu, Gokhan ; Hamagaki, Hideki ; Hamar, Gergö ; Hamid, Mohammed ; Hannigan, Ryan ; Haque, Md Rihan ; Harlenderova, Alena ; Gromada, Alena ; Harris, John William ; Harton, Austin Vincent ; Hasenbichler, Jan Anton ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Havener, Laura Brittany ; Hayashi, Shinichi ; Heckel, Stefan Thomas ; Hellbär, Ernst ; Helstrup, Håvard ; Herman, Tomáš ; Gonzalez Hernandez, Emma ; Herrera Corral, Gerardo Antonio ; Herrmann, Florian ; Hetland, Kristin Fanebust ; Hillemanns, Hartmut ; Hills, Christopher ; Hippolyte, Boris ; Hofman, Bas ; Hohlweger, Bernhard ; Honermann, Jan ; Hong, Geun Hee ; Horak, David ; Hornung, Sebastian ; Horzyk, Adrian ; Hosokawa, Ritsuya ; Hristov, Peter ; Huang, Chun-Lu ; Hughes, Charles ; Huhn, Patrick ; Humanic, Thomas J. ; Hushnud, Hushnud ; Husova, Lucia Anna ; Hutson, Alek ; Hutter, Dirk ; Iddon, James Philip ; Ilkaev, Radiy ; Ilyas, Hira ; Inaba, Motoi ; Innocenti, Gian Michele ; Ippolitov, Mikhail ; Isakov, Artem ; Islam, Md Samsul ; Ivanov, Marian ; Ivanov, Vladimir ; Izucheev, Vladimir ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Jacobs, Peter Martin ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jahnke, Cristiane ; Jakubowska, Monika Joanna ; Janik, Malgorzata Anna ; Janson, Thomas ; Jercic, Marko ; Jevons, Oliver Thomas ; Jonas, Florian ; Jones, Peter Graham ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Junique, Antoine Jean-Simon ; Jusko, Anton ; Kaewjai, Jetnipit ; Kalinak, Peter ; Kalweit, Alexander Philipp ; Kaplin, Vladimir ; Kar, Somnath ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana ; Karczmarczyk, Przemyslaw ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, Darius Laurens D. ; Keil, Markus ; Ketzer, Bernhard ; Khabanova, Zhanna ; Khan, Ahsan Mehmood ; Khan, Shaista ; Khanzadeev, Alexei ; Kharlov, Yury ; Khatun, Anisa ; Khuntia, Arvind ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Daehyeok ; Kim, Dong Jo ; Kim, Eun Joo ; Kim, Jaehyun ; Kim, Jin Sook ; Kim, Jiyoung ; Kim, Jungeol ; Kim, Junlee ; Kim, Minjung ; Kim, Se Yong ; Kim, Taejun ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kitowski, Jacek Pawel ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein, Spencer Robert ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Knospe, Anders Garritt ; Kobdaj, Chinorat ; Köhler, Markus Konrad ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia V. ; Kondratyuk, Evgeny ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Koryciak, Sebastian Dominik ; Koska, Lukas ; Kotliarov, Artem ; Kovalenko, Oleksandr ; Kovalenko, Vladimir ; Kowalski, Marek ; Králik, Ivan ; Kravčáková, Adela ; Kreis, Lukas ; Krivda, Marian ; Krizek, Filip ; Krizkova Gajdosova, Katarina ; Kroesen, Martin ; Kruger, Mario ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucera, Vit ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kumaoka, Takuya ; Kumar, Deekshit ; Kumar, Lokesh ; Kumar, Navneet ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kvapil, Jakub ; Kweon, Min Jung ; Kwon, Jiyeon ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lai, Yue Shi ; Lakrathok, Anantachai ; Lamanna, Massimo ; Langoy, Rune ; Lapidus, Kirill ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Lavicka, Roman ; Lazareva, Tatiana V. ; Lea, Ramona ; Lee, Joonil ; Lehrbach, Johannes ; Lemmon, Roy Crawford ; Leon Monzon, Ildefonso ; Lesser, Ezra Douglas ; Lettrich, Michael ; Lévai, Péter ; Li, Xiaomei ; Li, Xing Long ; Lien, Jørgen André ; Lietava, Roman ; Lim, Bong-Hwi ; Lim, Sanghoon ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Liu, Alwina Ruixin ; Liu, Jian ; Lofnes, Ingrid Mckibben ; Loginov, Vitaly ; Loizides, Constantinos ; Lončar, Petra ; López, Jorge Andres ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Luhder, Jens Robert ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Maevskaya, Alla ; Mager, Magnus ; Mahmoud, Tariq ; Maire, Antonin ; Malaev, Mikhail ; Malik, Qasim Waheed ; Malinina, Liudmila ; Mal'Kevich, Dmitry ; Mal'Kevich, Dmitry ; Mallick, Neelkamal ; Malzacher, Peter ; Mandaglio, Giuseppe ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marin, Ana ; Markert, Christina ; Marquard, Marco ; Martin, Nicole Alice ; Martinengo, Paolo ; Martinez, Jacobb Lee ; Martínez Hernández, Mario Iván ; Martínez Garcia, Ginés ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Mathis, Andreas Michael ; Matonoha, Oliver ; Matuoka, Paula Fernanda Toledo ; Matyja, Adam Tomasz ; Mayer, Christoph ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Mazzoni, Alessandra Maria ; Mdhluli, Joyful Elma ; Mechler, Adrian Florin ; Meddi, Franco ; Melikyan, Yury ; Menchaca-rocha, Arturo Alejandro ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Meres, Michal ; Mhlanga, Sibaliso ; Miake, Yasuo ; Micheletti, Luca ; Migliorin, Lucrezia Camilla ; Mihaylov, Dimitar ; Mikhaylov, Konstantin ; Mishra, Aditya Nath ; Miśkowiec, Dariusz Czesław ; Modak, Abhi ; Mohanty, Auro Prasad ; Mohanty, Bedangadas ; Khan, Mohammed Mohisin ; Moravcova, Zuzana ; Mordasini, Cindy ; Godoy, Denise Aparecida Moreira de ; Perez Moreno, Luis Alberto ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Mudnic, Eugen ; Muhlheim, Daniel ; Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Gameiro Munhoz, Marcelo ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myers, Corey James ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nair, Rahul Ramachandran ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Naru, Muhammad Umair ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Neagu, Alexandra ; Nellen, Lukas ; Nesbo, Simon Voigt ; Nešković, Gvozden ; Nesterov, Dmitrii ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, Seoyoung ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Osako, Takumi ; Oskarsson, Anders Nils Erik ; Otwinowski, Jacek Tomasz ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paic, Guy ; Palasciano, Antonio ; Pan, Jinjin ; Panebianco, Stefano Matthias ; Pareek, Pooja ; Park, Jonghan ; Parkkila, Jasper Elias ; Pathak, Surya Prakash ; Patra, Rajendra Nath ; Paul, Biswarup ; Pazzini, Jacopo ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pereira, Luis Gustavo ; Pereira da Costa, Hugo Denis Antonio ; Peresunko, Dmitry Yurevich ; Mesa Perez, Guillermo ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polishchuk, Boris ; Polichtchouk, Boris ; Politano, Stefano ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf, Sarah Julie ; Porteboeuf-Houssais, Sarah Julie ; Porter, R. Jefferson ; Pozdniakov, Valeriy ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Qiu, Shi ; Quaglia, Luca ; Quishpe Quishpe, Raquel Estefania ; Ragoni, Simone ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Rodríguez Ramírez, Saúl Aníbal ; Torres Ramos, Arianna Grisel ; Rancien, Thibaut Albert ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Rath, Rutuparna ; Ravasenga, Ivan ; Read, Kenneth Francis ; Redelbach, Andreas Ralph ; Redlich, Krzysztof ; Rehman, Attiq ur ; Reichelt, Patrick ; Reidt, Felix ; Reme-Ness, Haakon André ; Renfordt, Rainer Arno Ernst ; Rescakova, Zuzana ; Jakubcinova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor G. ; Richert, Tuva Ora Herenui ; Richter, Matthias Rudolph ; Riegler, Werner ; Riggi, Francesco ; Ristea, Cătălin-Lucian ; Rode, Sudhir Pandurang ; Rodrı́guez Cahuantzi, Mario ; Røed, Ketil ; Roeed, Ketil ; Rogalev, Roman ; Rogochaya, Elena ; Rogoschinski, Tim Sebastian ; Rohr, David ; Röhrich, Dieter ; Fierro Rojas, Pablo ; Rokita, Przemyslaw Stefan ; Ronchetti, Federico ; Rosano, Antonina ; Dominguez Rosas, Edgar ; Rossi, Andrea ; Rotondi, Alberto ; Roy, Ankhi ; Roy, Pradip Kumar ; Roy, Subhadeep ; Rubini, Nicola ; Vazquez Rueda, Omar ; Rui, Rinaldo ; Rumyantsev, Boris ; Russek, Paweł Grzegorz ; Rustamov, Anar ; Ryabinkin, Evgeny ; Ryabov, Yury ; Rybicki, Andrzej ; Rytkönen, Heidi Maria ; Rzęsa, Wioleta ; Saarimäki, Oskari Antti Matti ; Sadek, Rita ; Sadovskiy, Sergey ; Sætre, Jon-are ; Šafařík, Karel ; Saha, Sumit Kumar ; Saha, Swati ; Sahoo, Baidyanath ; Sahoo, Pragati ; Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Dushmanta ; Sahu, Pradip Kumar ; Saini, Jogender ; Sakai, Shingo ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Sarkar, Debojit ; Sarkar, Nachiketa ; Sarma, Pranjal ; Mantovani Sarti, Valentina ; Sas, Mike Henry Petrus ; Schambach, Johann Joachim ; Scheid, Horst Sebastian ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmah, Alexander ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schmidt, Marten Ole ; Schmidt, Martin ; Schmidt, Nicolas ; Schmier, Austin Robert ; Schotter, Romain ; Schukraft, Jürgen ; Schutz, Yves Roland ; Schwarz, Kilian Eberhard ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Seger, Janet Elizabeth ; Sekiguchi, Yuko ; Sekihata, Daiki ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Seo, Jin Joo ; Serebryakov, Dmitry ; Šerkšnytė, Laura ; Sevcenco, Adrian ; Shaba, Tebogo Joyce ; Shabanov, Arseniy ; Shabetai, Alexandre ; Shahoyan, Ruben ; Shaikh, Wadut ; Shangaraev, Artem ; Sharma, Anjali ; Sharma, Himanshu ; Sharma, Meenakshi ; Sharma, Natasha ; Sharma, Sheetal ; Sheibani, Oveis ; Shigaki, Kenta ; Hachiya Shimomura, Maya ; Shirinkin, Sergey ; Shou, Qiye ; Sibiryak, Yury ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Silva, Tiago Fiorini da ; Silvermyr, David Olle Rickard ; Simonetti, Giuseppe ; Singh, Bhawani ; Singh, Ranbir ; Singh, Randhir ; Singh, Ravindra ; Singh, Vivek ; Singhal, Vikas ; Sarkar - Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skorodumovs, Georgijs ; Slupecki, Maciej ; Smirnov, Nikolai ; Snellings, Raimond ; Soncco Meza, Carlos ; Song, Jihye ; Songmoolnak, Arnon ; Soramel, Francesca ; Sorensen, Soren Pontoppidan ; Sputowska, Iwona Anna ; Stachel, Johanna ; Stan, Ionel ; Steffanic, Patrick John ; Stiefelmaier, Stephan Friedrich ; Stocco, Diego ; Storehaug, Ida ; Storetvedt, Maksim Melnik ; Pliatskas Stylianidis, Christos ; Alarcon Do Passo Suaide, Alexandre ; Sugitate, Toru ; Suire, Christophe Pierre ; Šuljić, Miljenko ; Sultanov, Rishat ; Šumbera, Michal ; Sumberia, Vikash ; Sumowidagdo, Suharyo ; Swain, Sagarika ; Szabo, Alexander ; Szarka, Imrich ; Tabassam, Uzma ; Taghavi, Seyed Farid ; Taillepied, Guillaume ; Takahashi, Jun ; Tambave, Ganesh Jagannath ; Tang, Siyu ; Tang, Zebo ; Tarhini, Mohamad ; Tarzila, Madalina-Gabriela ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terlizzi, Livia ; Terrevoli, Cristina ; Tersimonov, Georgy ; Thakur, Sanchari ; Thomas, Deepa ; Tieulent, Raphael Noel ; Tikhonov, Anatoly ; Timmins, Anthony Robert ; Tkacik, Milan ; Toia, Alberica ; Topilskaya, Nataliya ; Toppi, Marco ; Torales Acosta, Fernando ; Tork, Theraa ; Cruz Torres, Reynier ; Rojas Torres, Solangel ; Trifiro, Antonio ; Tripathy, Sushanta ; Tripathy, Tulika ; Trogolo, Stefano ; Trombetta, Giuseppe ; Trubnikov, Victor ; Trzaska, Wladyslaw Henryk ; Trzcinski, Tomasz Piotr ; Trzeciak, Barbara Antonina ; Tumkin, Alexandr ; Turrisi, Rosario ; Tveter, Trine Spedstad ; Ullaland, Kjetil ; Uras, Antonio ; Urioni, Marta ; Usai, Gianluca ; Vala, Martin ; Valle, Nicolò ; Vallero, Sara ; Kolk, Naomi van der ; Doremalen, Lennart Vincent Rogier van ; Leeuwen, Marco van ; Vyvre, Pierre vande ; Varga, Dezsö ; Varga, Zoltán ; Varga-Kofarago, Monika ; Vargas Treviño, Maria Aurora Diozcora ; Vasileiou, Maria ; Vasiliev, Andrey ; Vazquez Doce, Oton ; Vechernin, Vladimir ; Vercellin, Ermanno ; Vergara Limon, Sergio ; Vermunt, Lucas Anne ; Vértesi, Róbert ; Verweij, Marta ; Vicković, Linda ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vino, Gioacchino ; Vinogradov, Alexander ; Virgili, Tiziano ; Vislavicius, Vytautas ; Vodopyanov, Alexander ; Volkel, Benedikt ; Volkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vorobyev, Ivan ; Voscek, Dominik ; Vrlakova, Janka ; Wagner, Boris ; Wang, Chunzheng ; Wang, Dongfang ; Weber, Michael ; Weelden, Roelof Jan Gijs van ; Wegrzynek, Adam Tadeusz ; Wenzel, Sandro Christian ; Wessels, Johannes P. ; Wiechula, Jens ; Wikne, Jon ; Wilk, Grzegorz Andrzej ; Wilkinson, Jeremy John ; Willems, Guido Alexander ; Windelband, Bernd ; Winn, Michael Andreas ; Witt, William Edward ; Wright, Josephina Rae ; Wu, Wenya ; Wu, Yitao ; Xu, Ran ; Yalcin Kuzu, Serpil ; Yamaguchi, Yorito ; Yamakawa, Kosei ; Yang, Shiming ; Yano, Satoshi ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yoon, Jin Hee ; Yuan, Shiming ; Yüncü, Alperen ; Zaccolo, Valentina ; Zaman, Ali ; Zampolli, Chiara ; Correia Zanoli, Henrique Jose ; Zardoshti, Nima ; Zarochentsev, Andrey ; Závada, Petr ; Zavyalov, Nikolay ; Zbroszczyk, Hanna Paulina ; Zhalov, Mikhail ; Zhang, Song ; Zhang, Xiaoming ; Zhang, Yifei ; Zherebchevskii, Vladimir ; Yu, Zhi ; Zhou, Daicui ; Zhou, You ; Zhu, Jianhui ; Zhu, Ya ; Zichichi, Antonino ; Zinovjev, Gennady M. ; Zurlo, Nicola
The ALICE Collaboration reports the first fully-corrected measurements of the N-subjettiness observable for track-based jets in heavy-ion collisions. This study is performed using data recorded in pp and Pb-Pb collisions at centre-of-mass energies of s√ = 7 TeV and sNN−−−√ = 2.76 TeV, respectively. In particular the ratio of 2-subjettiness to 1-subjettiness, τ2/τ1, which is sensitive to the rate of two-pronged jet substructure, is presented. Energy loss of jets traversing the strongly interacting medium in heavy-ion collisions is expected to change the rate of two-pronged substructure relative to vacuum. The results are presented for jets with a resolution parameter of R = 0.4 and charged jet transverse momentum of 40 ≤ pT,jet ≤ 60 GeV/c, which constitute a larger jet resolution and lower jet transverse momentum interval than previous measurements in heavy-ion collisions. This has been achieved by utilising a semi-inclusive hadron-jet coincidence technique to suppress the larger jet combinatorial background in this kinematic region. No significant modification of the τ2/τ1 observable for track-based jets in Pb-Pb collisions is observed relative to vacuum PYTHIA6 and PYTHIA8 references at the same collision energy. The measurements of τ2/τ1, together with the splitting aperture angle ∆R, are also performed in pp collisions at s√ = 7 TeV for inclusive jets. These results are compared with PYTHIA calculations at s√ = 7 TeV, in order to validate the model as a vacuum reference for the Pb-Pb centre-of-mass energy. The PYTHIA references for τ2/τ1 are shifted to larger values compared to the measurement in pp collisions. This hints at a reduction in the rate of two-pronged jets in Pb-Pb collisions compared to pp collisions.
Schob, Stefan ; Schicht, Martin ; Sel, Saadettin ; Stiller, Dankwart ; Kekulé, Alexander ; Paulsen, Friedrich ; Maronde, Erik ; Bräuer, Lars
Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system. The ability of surfactant protein A and surfactant protein D to bind various pathogens and facilitate their elimination has been described in a vast number of studies. Surfactant proteins are very important in modulating the host's inflammatory response and participate in the clearance of apoptotic cells. Surfactant protein B and surfactant protein C are proteins responsible for lowering the surface tension in the lungs. The aim of this study was an investigation of expression of surfactant proteins in the central nervous system to assess their specific distribution patterns. The second aim was to quantify surfactant proteins in cerebrospinal fluid of healthy subjects compared to patients suffering from different neuropathologies. The expression of mRNA for the surfactant proteins was analyzed with RT-PCR done with samples from different parts of the human brain. The production of the surfactant proteins in the brain was verified using immunohistochemistry and Western blot. The concentrations of the surfactant proteins in cerebrospinal fluid from healthy subjects and patients suffering from neuropathologic conditions were quantified using ELISA. Our results revealed that surfactant proteins are present in the central nervous system and that the concentrations of one or more surfactant proteins in healthy subjects differed significantly from those of patients affected by central autoimmune processes, CNS infections or cerebral infarction. Based on the localization of the surfactant proteins in the brain, their different levels in normal versus pathologic samples of cerebrospinal fluid and their well-known functions in the lungs, it appears that the surfactant proteins may play roles in host defense of the brain, facilitation of cerebrospinal fluid secretion and maintenance of the latter's rheological properties.
Hartkopf, Andreas ; Müller, Volkmar ; Wöckel, Achim ; Lux, Michael Patrick ; Janni, Wolfgang ; Nabieva, Naiba ; Ţăran, Florin-Andrei ; Ettl, Johannes ; Lüftner, Diana ; Belleville, Erik ; Schütz, Florian ; Fasching, Peter Andreas ; Fehm, Tanja ; Kolberg, Hans-Christian ; Overkamp, Friedrich ; Schneeweiss, Andreas ; Tesch, Hans
In der Prävention und Behandlung des frühen Mammakarzinoms sind über die Jahre immer wieder kleine, aber bedeutsame Fortschritte gemacht worden. In der Prävention gewinnen die sogenannten Panel-Gen-Analysen immer mehr an Bedeutung, da das durch die getesteten Gene bedingte Risiko immer besser verstanden wird und somit Konzepte für die Integration in die Krankenversorgung erarbeitet werden können. In der adjuvanten Situation konnte die erste Studie in der sogenannten postneoadjuvanten Situation bei fehlender pathologischer Komplettremission nach Trastuzumab oder Pertuzumab + Trastuzumab eine deutliche Verbesserung der Prognose zeigen. Weitere Studien mit diesem postneoadjuvanten Therapiekonzept werden zurzeit noch durchgeführt. Die CDK4/6-Inhibitoren, die in der metastasierten Situation eine deutliche Verbesserung des progressionsfreien Überlebens gezeigt hatten, werden zurzeit in der adjuvanten Situation in großen Therapiestudien getestet. Diese und weitere neue Daten zur Behandlung oder Prävention des primären Mammakarzinoms werden in dieser Übersichtsarbeit vor dem Hintergrund aktueller Studien vorgestellt.
Hübner, Hanna ; Kurbacher, Christian M. ; Kuesters, Geoffrey ; Hartkopf, Andreas D. ; Lux, Michael P. ; Huober, Jens ; Volz, Bernhard ; Ţăran, Florin-Andrei ; Overkamp, Friedrich ; Tesch, Hans ; Häberle, Lothar ; Lüftner, Diana ; Wallwiener, Markus ; Müller, Volkmar ; Beckmann, Matthias Wilhelm ; Belleville, Erik ; Rübner, Matthias ; Untch, Michael ; Fasching, Peter Andreas ; Janni, Wolfgang ; Fehm, Tanja ; Kolberg, Hans-Christian ; Wallwiener, Diethelm ; Brucker, Sara Y. ; Schneeweiss, Andreas ; Ettl, Johannes
Background: Eligibility criteria are a critical part of clinical trials, as they define the patient population under investigation. Besides certain patient characteristics, clinical trials often include biomarker testing for eligibility. However, patient-identification mostly relies on the trial site itself and is often a time-consuming procedure, which could result in missing out on potentially eligible patients. Pre-selection of those patients using a registry could facilitate the process of eligibility testing and increase the number of identified patients. One aim with the PRAEGNANT registry (NCT02338167) is to identify patients for therapies based on clinical and molecular data. Here, we report eligibility testing for the SHERBOC trial using the German PRAEGNANT registry.
Methods:Heregulin (HRG) has been reported to identify patients with better responses to therapy with the anti-HER3 monoclonal antibody seribantumab (MM-121). The SHERBOC trial investigated adding seribantumab (MM-121) to standard therapy in patients with advanced HER2-negative, hormone receptor–positive (HR-positive) breast cancer and HRG overexpression. The PRAEGNANT registry was used for identification and tumor testing, helping to link potential HRG positive patients to the trial. Patients enrolled in PRAEGNANT have invasive and metastatic or locally advanced, inoperable breast cancer. Patients eligible for SHERBOC were identified by using the registry. Study aims were to describe the HRG positivity rate, screening procedures, and patient characteristics associated with inclusion and exclusion criteria.
Results: Among 2769 unselected advanced breast cancer patients, 650 were HER2-negative, HR-positive and currently receiving first- or second-line treatment, thus potentially eligible for SHERBOC at the end of current treatment; 125 patients also met further clinical eligibility criteria (e.g. menopausal status, ECOG). In the first/second treatment lines, patients selected for SHERBOC based on further eligibility criteria had a more favorable prognosis than those not selected. HRG status was tested in 38 patients, 14 of whom (36.8%) proved to be HRG-positive.
Conclusion: Using a real-world breast cancer registry allowed identification of potentially eligible patients for SHERBOC focusing on patients with HER3 overexpressing, HR-positive, HER2-negative metastatic breast cancer. This approach may provide insights into differences between patients eligible or non-eligible for clinical trials.
Trial registration: Clinicaltrials, NCT02338167, Registered 14 January 2015 - retrospectively registered.
Lux, Michael Patrick ; Nabieva, Naiba ; Hartkopf, Andreas ; Huober, Jens ; Volz, Bernhard ; Ţăran, Florin-Andrei ; Overkamp, Friedrich ; Kolberg, Hans-Christian ; Hadji, Peyman ; Tesch, Hans ; Häberle, Lothar ; Ettl, Johannes ; Lüftner, Diana ; Wallwiener, Markus ; Müller, Volkmar ; Beckmann, Matthias Wilhelm ; Belleville, Erik ; Wimberger, Pauline ; Hielscher, Carsten ; Geberth, Matthias ; Abenhardt, Wolfgang ; Kurbacher, Christian M. ; Würstlein, Rachel ; Thomssen, Christoph ; Untch, Michael ; Fasching, Peter Andreas ; Janni, Wolfgang ; Fehm, Tanja ; Wallwiener, Diethelm ; Schneeweiss, Andreas ; Brucker, Sara
This study presents comprehensive real-world data on the use of anti-human epidermal growth factor receptor 2 (HER2) therapies in patients with HER2-positive metastatic breast cancer (MBC). Specifically, it describes therapy patterns with trastuzumab (H), pertuzumab + trastuzumab (PH), lapatinib (L), and trastuzumab emtansine (T-DM1). The PRAEGNANT study is a real-time, real-world registry for MBC patients. All therapy lines are documented. This analysis describes the utilization of anti-HER2 therapies as well as therapy sequences. Among 1936 patients in PRAEGNANT, 451 were HER2-positive (23.3%). In the analysis set (417 patients), 53% of whom were included in PRAEGNANT in the first-line setting, 241 were treated with H, 237 with PH, 85 with L, and 125 with T-DM1 during the course of their therapies. The sequence PH → T-DM1 was administered in 51 patients. Higher Eastern Cooperative Oncology Group (ECOG) scores, negative hormone receptor status, and visceral or brain metastases were associated with more frequent use of this therapy sequence. Most patients received T-DM1 after treatment with pertuzumab. Both novel therapies (PH and T-DM1) are utilized in a high proportion of HER2-positive breast cancer patients. As most patients receive T-DM1 after PH, real-world data may help to clarify whether the efficacy of this sequence is similar to that in the approval study.