Refine
Author
- Adolfsson, Rolf (1)
- Adorjan, Kristina (1)
- Agerbo, Esben (1)
- Albani, Diego (1)
- Alda, Martin (1)
- Alemany, Silvia (1)
- Alfredsson, Lars (1)
- Alliey-Rodriguez, Ney (1)
- Als, Thomas D. (1)
- Andlauer, Till F. M. (1)
- Andreassen, Ole A. (1)
- Antoniou, Anastasia (1)
- Ask, Helga (1)
- Backlund, Lena (1)
- Bass, Nicholas (1)
- Bauer, Michael (1)
- Baune, Bernhard T. (1)
- Beins, Eva C. (1)
- Bellivier, Frank (1)
- Bendl, Jaroslav (1)
- Bengesser, Susanne (1)
- Berrettini, Wade H. (1)
- Biernacka, Joanna M. (1)
- Bigdeli, Tim B. (1)
- Bloos, Frank (1)
- Boehnke, Michael (1)
- Boks, Marco P. (1)
- Boltz, Toni (1)
- Bosch, Rosa (1)
- Breen, Gerome (1)
- Briegel, Josef (1)
- Brum, Murielle (1)
- Brumpton, Ben M. (1)
- Brunkhorst, Frank Martin (1)
- Brunkhorst-Kanaan, Nathalie (1)
- Budde, Monika (1)
- Bybjerg-Grauholm, Jonas (1)
- Byerley, William (1)
- Børglum, Anders D. (1)
- Børte, Sigrid (1)
- Cabana-Domínguez, Judit (1)
- Cairns, Murray J. (1)
- Carpiniello, Bernardo (1)
- Carr, Vaughan J. (1)
- Casas, Miquel (1)
- Catts, Stanley (1)
- Cervantes, Pablo (1)
- Chatzinakos, Chris (1)
- Chen, Hsi-Chung (1)
- Cichon, Sven (1)
- Clarence, Tereza (1)
- Clarke, Toni-Kim (1)
- Claus, Isabelle (1)
- Coleman, Jonathan R. I. (1)
- Coombes, Brandon (1)
- Corfield, Elizabeth C. (1)
- Corvin, Aiden (1)
- Craddock, Nicholas (1)
- Cruceanu, Cristiana (1)
- Cuellar-Barboza, Alfredo (1)
- Czerski, Piotr M. (1)
- Dafnas, Konstantinos (1)
- Dale, Anders M. (1)
- Dalkner, Nina (1)
- Dannlowski, Udo (1)
- David, Friederike S. (1)
- DePaulo, J. Raymond (1)
- Degenhardt, Franziska (1)
- Di Florio, Arianna (1)
- Dikeos, Dimitris (1)
- Djurovic, Srdjan (1)
- Drange, Ole Kristian (1)
- Edenberg, Howard J. (1)
- Elke, Gunnar (1)
- Escott-Price, Valentina (1)
- Etain, Bruno (1)
- Fanous, Ayman H. (1)
- Fellendorf, Frederike T. (1)
- Ferentinos, Panagiotis (1)
- Ferrier, I. Nicol (1)
- Forstner, Andreas J. (1)
- Forty, Liz (1)
- Frank, Josef (1)
- Frei, Oleksandr (1)
- Freimer, Nelson B. (1)
- Frye, Mark (1)
- Fullard, John F. (1)
- Fullerton, Janice M. (1)
- Garnham, Julie (1)
- Gawlik, Micha (1)
- Gershon, Elliot S. (1)
- Gizer, Ian R. (1)
- Goes, Fernando S. (1)
- Gordon, Scott D. (1)
- Gordon-Smith, Katherine (1)
- Green, Melissa J. (1)
- Greenwood, Tiffany A. (1)
- Grigoroiu-Serbanescu, Maria (1)
- Grove, Jakob (1)
- Guzman-Parra, José (1)
- Ha, Tae Hyon (1)
- Hahn, Tim (1)
- Haraldsson, Magnus (1)
- Harder, Arvid (1)
- Hauser, Joanna (1)
- Hautzinger, Martin (1)
- Havdahl, Alexandra (1)
- Heilbronner, Urs (1)
- Hellgren, Dennis (1)
- Henskens, Frans A. (1)
- Herms, Stefan (1)
- Hickie, Ian B. (1)
- Hjerling-Leffler, Jens (1)
- Hoffmann, Per (1)
- Holmans, Peter A. (1)
- Hougaard, David M. (1)
- Huang, Ming-Chyi (1)
- Hveem, Kristian (1)
- Ikeda, Masashi (1)
- Iwata, Nakao (1)
- Jamain, Stéphane (1)
- Jaschinski, Ulrich (1)
- Johnson, Jessica S. (1)
- Jones, Ian (1)
- Jones, Lisa A. (1)
- Jonsson, Lina (1)
- Kahn, René S. (1)
- Kalman, Janos L. (1)
- Kamatani, Yoichiro (1)
- Kay Yang, Jessica Mei (1)
- Kelsoe, John R. (1)
- Kennedy, James L. (1)
- Kim, Euitae (1)
- Kim, Jaeyoung (1)
- Kircher, Tilo (1)
- Kirov, George (1)
- Kittel-Schneider, Sarah (1)
- Kluge, Stefan (1)
- Knowles, James A. (1)
- Koch, Elise (1)
- Kogevinas, Manolis (1)
- Koromina, Maria (1)
- Kranz, Thorsten M. (1)
- Krebs, Kristi (1)
- Kuo, Po-Hsiu (1)
- Kushner, Steven A. (1)
- Landén, Mikael (1)
- Lavebratt, Catharina (1)
- Lawrence, Jacob (1)
- Leber, Markus (1)
- Leboyer, Marion (1)
- Lee, Heon-Jeong (1)
- Li, Qingqin S. (1)
- Liao, Calwing (1)
- Lin, Keng-Han (1)
- Lind, Penelope A. (1)
- Lissowska, Jolanta (1)
- Lochner, Christine (1)
- Loughland, Carmel (1)
- Lucae, Susanne (1)
- Lundberg, Martin (1)
- Luykx, Jurjen J. (1)
- Löffler, Markus (1)
- MacIntyre, Donald J. (1)
- Maier, Wolfgang (1)
- Maihofer, Adam X. (1)
- Malaspina, Dolores (1)
- Manchia, Mirko (1)
- Maratou, Eirini (1)
- Martin, Nicholas G. (1)
- Martinsson, Lina (1)
- Mathews, Carol A. (1)
- Mattheisen, Manuel (1)
- Mayoral, Fermin (1)
- McElroy, Susan L. (1)
- McGregor, Nathaniel W. (1)
- McGrouther, Caroline C. (1)
- McInnis, Melvin G. (1)
- McIntosh, Andrew M. (1)
- McKay, James D. (1)
- McMahon, Francis J. (1)
- McQuillin, Andrew (1)
- Medeiros, Helena (1)
- Medland, Sarah E. (1)
- Melle, Ingrid (1)
- Meybohm, Patrick (1)
- Meyer-Lindenberg, Andreas (1)
- Milani, Lili (1)
- Millischer, Vincent (1)
- Mitchell, Brittany L. (1)
- Mitchell, Philip B. (1)
- Morken, Gunnar (1)
- Morris, Derek W. (1)
- Mors, Ole (1)
- Mortensen, Preben Bo (1)
- Moutsatsou, Paraskevi (1)
- Mullins, Niamh (1)
- Myers, Richard M. (1)
- Myung, Woojae (1)
- Mörer, Onnen (1)
- Mühleisen, Thomas W. (1)
- Müller-Myhsok, Bertram (1)
- Neale, Benjamin M. (1)
- Nierhaus, Axel (1)
- Nievergelt, Caroline M. (1)
- Nordentoft, Merete (1)
- Nurnberger, John I. (1)
- Nöthen, Markus M. (1)
- Oedegaard, Ketil J. (1)
- Olsen, Catherine M. (1)
- Olsson, Tomas (1)
- Ophoff, Roel A. (1)
- Owen, Michael J. (1)
- O’Connell, Kevin S. (1)
- O’Donovan, Claire (1)
- O’Donovan, Michael C. (1)
- Paciga, Sara A. (1)
- Panagiotaropoulou, Georgia (1)
- Pantelis, Christos (1)
- Papiol, Sergi (1)
- Pardiñas, Antonio F. (1)
- Park, Hye Youn (1)
- Parker, Nadine (1)
- Pato, Carlos N. (1)
- Pato, Michele T. (1)
- Patrinos, George P. (1)
- Pawlak, Joanna M. (1)
- Pedersen, Carsten Bøcker (1)
- Perry, Amy (1)
- Pfennig, Andrea (1)
- Pisanu, Claudia (1)
- Potash, James B. (1)
- Quested, Digby (1)
- Ramos-Quiroga, Josep Antoni (1)
- Rangan, Aaditya V. (1)
- Rapaport, Mark H. (1)
- Regeer, Eline J. (1)
- Reif, Andreas (1)
- Reinhart, Konrad (1)
- Reininghaus, Eva Z. (1)
- Ribasés, Marta (1)
- Rice, John P. (1)
- Rietschel, Marcella (1)
- Ripke, Stephan (1)
- Rivera, Margarita (1)
- Rouleau, Guy A. (1)
- Roussos, Panos (1)
- Saito, Takeo (1)
- Schall, Ulrich (1)
- Schalling, Martin (1)
- Schofield, Peter R. (1)
- Schulte, Eva Christina (1)
- Schulze, Thomas G. (1)
- Scott, Laura J. (1)
- Scott, Rodney J. (1)
- Senner, Fanny (1)
- Serretti, Alessandro (1)
- Shadrin, Alexey (1)
- Shilling, Paul D. (1)
- Sigurdsson, Engilbert (1)
- Sindermann, Lisa (1)
- Sirignano, Lea (1)
- Siskind, Dan (1)
- Slaney, Claire (1)
- Sloofman, Laura G. (1)
- Smeland, Olav B. (1)
- Smith, Daniel J. (1)
- Smoller, Jordan W. (1)
- Sobell, Janet L. (1)
- Soler Artigas, Maria (1)
- Squassina, Alessio (1)
- Stahl, Eli A. (1)
- Stefansson, Hreinn (1)
- Stefansson, Kari (1)
- Stein, Dan J. (1)
- Stein, Frederike (1)
- Stordal, Eystein (1)
- Streit, Fabian (1)
- Su, Mei-Hsin (1)
- Sullivan, Patrick F. (1)
- Sung, Heejong (1)
- Terao, Chikashi (1)
- Tesfaye, Markos (1)
- Tesli, Martin (1)
- Thorgeirsson, Thorgeir E. (1)
- Thorp, Jackson G. (1)
- Toma, Claudio (1)
- Tondo, Leonardo (1)
- Tooney, Paul A. (1)
- Tsai, Shih-Jen (1)
- Tsermpini, Evangelia Eirini (1)
- Turecki, Gustavo (1)
- Vaaler, Arne E. (1)
- Vawter, Marquis P. (1)
- Vedder, Helmut (1)
- Vieta, Eduard (1)
- Vincent, John B. (1)
- Vreeker, Annabel (1)
- Waldman, Irwin D. (1)
- Walters, James T. R. (1)
- Wang, Xin (1)
- Weickert, Cynthia S. (1)
- Weickert, Thomas W. (1)
- Werge, Thomas (1)
- Weyland, Andreas (1)
- Whiteman, David C. (1)
- Wilson, Darius Cameron (1)
- Winsvold, Bendik S. (1)
- Witt, Stephanie H. (1)
- Won, Hong-Hee (1)
- Ye, Robert (1)
- Young, Allan H. (1)
- Zandi, Peter P. (1)
- Zillich, Lea (1)
- Zwart, John-Anker (1)
- van der Veen, Tracey (1)
- Świątkowska, Beata (1)
Language
- English (2)
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Keywords
- Biomarkers (1)
- MR-proADM (1)
- Mortality (1)
- SOFA (1)
- Sepsis (1)
- Septic shock (1)
Institute
- Medizin (2)
O’Connell, Kevin S. ; Koromina, Maria ; van der Veen, Tracey ; Boltz, Toni ; David, Friederike S. ; Kay Yang, Jessica Mei ; Lin, Keng-Han ; Wang, Xin ; Coleman, Jonathan R. I. ; Mitchell, Brittany L. ; McGrouther, Caroline C. ; Rangan, Aaditya V. ; Lind, Penelope A. ; Koch, Elise ; Harder, Arvid ; Parker, Nadine ; Bendl, Jaroslav ; Adorjan, Kristina ; Agerbo, Esben ; Albani, Diego ; Alemany, Silvia ; Alliey-Rodriguez, Ney ; Als, Thomas D. ; Andlauer, Till F. M. ; Antoniou, Anastasia ; Ask, Helga ; Bass, Nicholas ; Bauer, Michael ; Beins, Eva C. ; Bigdeli, Tim B. ; Pedersen, Carsten Bøcker ; Boks, Marco P. ; Børte, Sigrid ; Bosch, Rosa ; Brum, Murielle ; Brumpton, Ben M. ; Brunkhorst-Kanaan, Nathalie ; Budde, Monika ; Bybjerg-Grauholm, Jonas ; Byerley, William ; Cabana-Domínguez, Judit ; Cairns, Murray J. ; Carpiniello, Bernardo ; Casas, Miquel ; Cervantes, Pablo ; Chatzinakos, Chris ; Chen, Hsi-Chung ; Clarence, Tereza ; Clarke, Toni-Kim ; Claus, Isabelle ; Coombes, Brandon ; Corfield, Elizabeth C. ; Cruceanu, Cristiana ; Cuellar-Barboza, Alfredo ; Czerski, Piotr M. ; Dafnas, Konstantinos ; Dale, Anders M. ; Dalkner, Nina ; Degenhardt, Franziska ; DePaulo, J. Raymond ; Djurovic, Srdjan ; Drange, Ole Kristian ; Escott-Price, Valentina ; Fanous, Ayman H. ; Fellendorf, Frederike T. ; Ferrier, I. Nicol ; Forty, Liz ; Frank, Josef ; Frei, Oleksandr ; Freimer, Nelson B. ; Fullard, John F. ; Garnham, Julie ; Gizer, Ian R. ; Gordon, Scott D. ; Gordon-Smith, Katherine ; Greenwood, Tiffany A. ; Grove, Jakob ; Guzman-Parra, José ; Ha, Tae Hyon ; Hahn, Tim ; Haraldsson, Magnus ; Hautzinger, Martin ; Havdahl, Alexandra ; Heilbronner, Urs ; Hellgren, Dennis ; Herms, Stefan ; Hickie, Ian B. ; Hoffmann, Per ; Holmans, Peter A. ; Huang, Ming-Chyi ; Ikeda, Masashi ; Jamain, Stéphane ; Johnson, Jessica S. ; Jonsson, Lina ; Kalman, Janos L. ; Kamatani, Yoichiro ; Kennedy, James L. ; Kim, Euitae ; Kim, Jaeyoung ; Kittel-Schneider, Sarah ; Knowles, James A. ; Kogevinas, Manolis ; Kranz, Thorsten M. ; Krebs, Kristi ; Kushner, Steven A. ; Lavebratt, Catharina ; Lawrence, Jacob ; Leber, Markus ; Lee, Heon-Jeong ; Liao, Calwing ; Lucae, Susanne ; Lundberg, Martin ; MacIntyre, Donald J. ; Maier, Wolfgang ; Maihofer, Adam X. ; Malaspina, Dolores ; Manchia, Mirko ; Maratou, Eirini ; Martinsson, Lina ; Mattheisen, Manuel ; McGregor, Nathaniel W. ; McInnis, Melvin G. ; McKay, James D. ; Medeiros, Helena ; Meyer-Lindenberg, Andreas ; Millischer, Vincent ; Morris, Derek W. ; Moutsatsou, Paraskevi ; Mühleisen, Thomas W. ; O’Donovan, Claire ; Olsen, Catherine M. ; Panagiotaropoulou, Georgia ; Papiol, Sergi ; Pardiñas, Antonio F. ; Park, Hye Youn ; Perry, Amy ; Pfennig, Andrea ; Pisanu, Claudia ; Potash, James B. ; Quested, Digby ; Rapaport, Mark H. ; Regeer, Eline J. ; Rice, John P. ; Rivera, Margarita ; Schulte, Eva Christina ; Senner, Fanny ; Shadrin, Alexey ; Shilling, Paul D. ; Sigurdsson, Engilbert ; Sindermann, Lisa ; Sirignano, Lea ; Siskind, Dan ; Slaney, Claire ; Sloofman, Laura G. ; Smeland, Olav B. ; Smith, Daniel J. ; Sobell, Janet L. ; Soler Artigas, Maria ; Stein, Dan J. ; Stein, Frederike ; Su, Mei-Hsin ; Sung, Heejong ; Świątkowska, Beata ; Terao, Chikashi ; Tesfaye, Markos ; Tesli, Martin ; Thorgeirsson, Thorgeir E. ; Thorp, Jackson G. ; Toma, Claudio ; Tondo, Leonardo ; Tooney, Paul A. ; Tsai, Shih-Jen ; Tsermpini, Evangelia Eirini ; Vawter, Marquis P. ; Vedder, Helmut ; Vreeker, Annabel ; Walters, James T. R. ; Winsvold, Bendik S. ; Witt, Stephanie H. ; Won, Hong-Hee ; Ye, Robert ; Young, Allan H. ; Zandi, Peter P. ; Zillich, Lea ; Adolfsson, Rolf ; Alda, Martin ; Alfredsson, Lars ; Backlund, Lena ; Baune, Bernhard T. ; Bellivier, Frank ; Bengesser, Susanne ; Berrettini, Wade H. ; Biernacka, Joanna M. ; Boehnke, Michael ; Børglum, Anders D. ; Breen, Gerome ; Carr, Vaughan J. ; Catts, Stanley ; Cichon, Sven ; Corvin, Aiden ; Craddock, Nicholas ; Dannlowski, Udo ; Dikeos, Dimitris ; Etain, Bruno ; Ferentinos, Panagiotis ; Frye, Mark ; Fullerton, Janice M. ; Gawlik, Micha ; Gershon, Elliot S. ; Goes, Fernando S. ; Green, Melissa J. ; Grigoroiu-Serbanescu, Maria ; Hauser, Joanna ; Henskens, Frans A. ; Hjerling-Leffler, Jens ; Hougaard, David M. ; Hveem, Kristian ; Iwata, Nakao ; Jones, Ian ; Jones, Lisa A. ; Kahn, René S. ; Kelsoe, John R. ; Kircher, Tilo ; Kirov, George ; Kuo, Po-Hsiu ; Landén, Mikael ; Leboyer, Marion ; Li, Qingqin S. ; Lissowska, Jolanta ; Lochner, Christine ; Loughland, Carmel ; Luykx, Jurjen J. ; Martin, Nicholas G. ; Mathews, Carol A. ; Mayoral, Fermin ; McElroy, Susan L. ; McIntosh, Andrew M. ; McMahon, Francis J. ; Medland, Sarah E. ; Melle, Ingrid ; Milani, Lili ; Mitchell, Philip B. ; Morken, Gunnar ; Mors, Ole ; Mortensen, Preben Bo ; Müller-Myhsok, Bertram ; Myers, Richard M. ; Myung, Woojae ; Neale, Benjamin M. ; Nievergelt, Caroline M. ; Nordentoft, Merete ; Nöthen, Markus M. ; Nurnberger, John I. ; O’Donovan, Michael C. ; Oedegaard, Ketil J. ; Olsson, Tomas ; Owen, Michael J. ; Paciga, Sara A. ; Pantelis, Christos ; Pato, Carlos N. ; Pato, Michele T. ; Patrinos, George P. ; Pawlak, Joanna M. ; Ramos-Quiroga, Josep Antoni ; Reif, Andreas ; Reininghaus, Eva Z. ; Ribasés, Marta ; Rietschel, Marcella ; Ripke, Stephan ; Rouleau, Guy A. ; Roussos, Panos ; Saito, Takeo ; Schall, Ulrich ; Schalling, Martin ; Schofield, Peter R. ; Schulze, Thomas G. ; Scott, Laura J. ; Scott, Rodney J. ; Serretti, Alessandro ; Smoller, Jordan W. ; Squassina, Alessio ; Stahl, Eli A. ; Stefansson, Hreinn ; Stefansson, Kari ; Stordal, Eystein ; Streit, Fabian ; Sullivan, Patrick F. ; Turecki, Gustavo ; Vaaler, Arne E. ; Vieta, Eduard ; Vincent, John B. ; Waldman, Irwin D. ; Weickert, Cynthia S. ; Weickert, Thomas W. ; Werge, Thomas ; Whiteman, David C. ; Zwart, John-Anker ; Edenberg, Howard J. ; McQuillin, Andrew ; Forstner, Andreas J. ; Mullins, Niamh ; Di Florio, Arianna ; Ophoff, Roel A. ; Andreassen, Ole A.
Elke, Gunnar ; Bloos, Frank ; Wilson, Darius Cameron ; Brunkhorst, Frank Martin ; Briegel, Josef ; Reinhart, Konrad ; Löffler, Markus ; Kluge, Stefan ; Nierhaus, Axel ; Jaschinski, Ulrich ; Mörer, Onnen ; Weyland, Andreas ; Meybohm, Patrick
Background: This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease severity in patients with sepsis.
Methods: This is a secondary analysis of a randomised controlled trial in patients with severe sepsis or septic shock across 33 German intensive care units. The association between biomarkers and clinical scores with mortality was assessed by Cox regression analysis, area under the receiver operating characteristic and Kaplan-Meier curves. Patients were stratified into three severity groups (low, intermediate, high) for all biomarkers and scores based on cutoffs with either a 90% sensitivity or specificity.
Results: 1089 patients with a 28-day mortality rate of 26.9% were analysed. According to the Sepsis-3 definition, 41.2% and 58.8% fulfilled the criteria for sepsis and septic shock, with respective mortality rates of 20.0% and 32.1%. MR-proADM had the strongest association with mortality across all Sepsis-1 and Sepsis-3 subgroups and could facilitate a more accurate classification of low (e.g. MR-proADM vs. SOFA: N = 265 vs. 232; 9.8% vs. 13.8% mortality) and high (e.g. MR-proADM vs. SOFA: N = 161 vs. 155; 55.9% vs. 41.3% mortality) disease severity. Patients with decreasing PCT concentrations of either ≥ 20% (baseline to day 1) or ≥ 50% (baseline to day 4) but continuously high MR-proADM concentrations had a significantly increased mortality risk (HR (95% CI): 19.1 (8.0–45.9) and 43.1 (10.1–184.0)).
Conclusions: MR-proADM identifies disease severity and treatment response more accurately than established biomarkers and scores, adding additional information to facilitate rapid clinical decision-making and improve personalised sepsis treatment.
- 1 to 2