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Institute
Ice-nucleating particle concentrations of the past: insights from a 600-year-old Greenland ice core
(2020)
Schrod, Jann Erik ; Kleinhenz, Dominik ; Hörhold, Maria ; Erhardt, Tobias ; Richter, Sarah ; Wilhelms, Frank ; Fischer, Hubertus ; Ebert, Martin ; Twarloh, Birthe ; Della Lunga, Damiano ; Jensen, Camilla Marie ; Curtius, Joachim ; Bingemer, Heinz
Ice-nucleating particles (INPs) affect the microphysics in cloud and precipitation processes. Hence, they modulate the radiative properties of clouds. However, atmospheric INP concentrations of the past are basically unknown. Here, we present INP measurements from an ice core in Greenland, which dates back to the year 1370. In total 135 samples were analyzed with the FRIDGE droplet freezing assay in the temperature range from −14 to −35 ∘C. The sampling frequency was set to 1 in 10 years from 1370 to 1960. From 1960 to 1990 the frequency was increased to one sample per year. Additionally, a few special events were probed, including volcanic episodes. The typical time coverage of a sample was on the order of a few months. Historical atmospheric INP concentrations were estimated with a conversion factor, which depends on the snow accumulation rate of the ice core, particle dry deposition velocity, and wet scavenging ratio. Typical atmospheric INP concentrations were on the order of 0.1 L−1 at −25 ∘C. The INP variability was found to be about 1–2 orders of magnitude. Yet, the short-term variability from samples over a seasonal cycle was considerably lower. INP concentrations were significantly correlated to some chemical tracers derived from continuous-flow analysis (CFA) and ion chromatography (IC) over a broad range of nucleation temperatures. The highest correlation coefficients were found for the particle concentration (spherical diameter dp > 1.2 µm). The correlation is higher for a time period of seasonal samples, where INP concentrations follow a clear annual pattern, highlighting the importance of the annual dust input in Greenland from East Asian deserts during spring. Scanning electron microscopy (SEM) analysis of selected samples found mineral dust to be the dominant particle fraction, verifying their significance as INPs. Overall, the concentrations compare reasonably well to present-day INP concentrations, albeit they are on the lower side. However, we found that the INP concentration at medium supercooled temperatures differed before and after 1960. Average INP concentrations at −23, −24, −25, −26, and −28 ∘C were significantly higher (and more variable) in the modern-day period, which could indicate a potential anthropogenic impact, e.g., from land-use change.
Ice nucleating particle concentrations of the past: insights from a
600 year old Greenland ice core
(2020)
Schrod, Jann Erik ; Kleinhenz, Dominik ; Hörhold, Maria ; Erhardt, Tobias ; Richter, Sarah ; Wilhelms, Frank ; Fischer, Hubertus ; Ebert, Martin ; Twarloh, Birthe ; Della Lunga, Damiano ; Jensen, Camilla Marie ; Curtius, Joachim ; Bingemer, Heinz
Ice nucleating particles (INPs) affect the microphysics in cloud and precipitation processes. Hence, they modulate the radiative properties of clouds. However, atmospheric INP concentrations of the past are basically unknown. Here, we present INP measurements from an ice core in Greenland, which dates back to the year 1370. In total 135 samples were analyzed with the FRIDGE droplet freezing assay in the temperature range from −14 ◦C to −35 ◦C. The sampling frequency was set to 1 in 10 years from 1370 to 1960. From 1960 to 1990 the frequency was increased to 1 sample per year. Additionally, a number of special events were probed, including volcanic episodes. The typical time coverage of a sample was on the order of a few months. Historical atmospheric INP concentrations were estimated with a conversion factor, which depends on the snow accumulation rate of the ice core, particle dry deposition velocity and the wet scavenging ratio. Typical atmospheric INP concentrations were on the order of 0.1 L -1 at −25 ◦C. The INP variability was found to be about 1 – 2 orders of magnitude. Yet, the short-term variability from samples over a seasonal cycle was considerably lower. INP concentrations were significantly correlated to chemical tracers derived from continuous flow analysis (CFA) and ion chromatography (IC) over a broad range of nucleation temperatures. The highest correlation coefficients were found for the particle concentration (dp > 1.2 µm). The correlation is higher for the seasonal samples, where INP concentrations follow a clear annual pattern, highlighting the importance of the annual dust input in Greenland from East Asian deserts during spring. Scanning electron microscopy (SEM) of single particles retrieved from selected samples found particles of soil origin to be the dominant fraction, verifying the significance of mineral dust particles as INPs. Overall, the concentrations compare reasonably well to present day INP concentrations, albeit they are on the lower side. However, we found that the INP concentration at medium supercooled temperatures differed before and after 1960. Average INP concentrations at −23 ◦C, −24 ◦C, −25 ◦C, −26 ◦C and −28 ◦C were significantly higher (and more variable) in the modern day period, which could indicate a potential anthropogenic impact or some post-coring contamination of the topmost, very porous firn.
Stenner, Frank ; Liewen, Heike ; Göttig, Stephan ; Henschler, Reinhard ; Markuly, Norbert ; Kleber, Sascha ; Faust, Michael ; Mischo, Axel ; Bauer, Stefan ; Zweifel, Martin ; Knuth, Alexander ; Renner, Christoph ; Wadle, Andreas
RP1 (synonym: MAPRE2, EB2) is a member of the microtubule binding EB1 protein family, which interacts with APC, a key regulatory molecule in the Wnt signalling pathway. While the other EB1 proteins are well characterized the cellular function and regulation of RP1 remain speculative to date. However, recently RP1 has been implicated in pancreatic cancerogenesis. CK2 is a pleiotropic kinase involved in adhesion, proliferation and anti-apoptosis. Overexpression of protein kinase CK2 is a hallmark of many cancers and supports the malignant phenotype of tumor cells. In this study we investigate the interaction of protein kinase CK2 with RP1 and demonstrate that CK2 phosphorylates RP1 at Ser236 in vitro. Stable RP1 expression in cell lines leads to a significant cleavage and down-regulation of N-cadherin and impaired adhesion. Cells expressing a Phospho-mimicking point mutant RP1-ASP236 show a marked decrease of adhesion to endothelial cells under shear stress. Inversely, we found that the cells under shear stress downregulate endogenous RP1, most likely to improve cellular adhesion. Accordingly, when RP1 expression is suppressed by shRNA, cells lacking RP1 display significantly increased cell adherence to surfaces. In summary, RP1 phosphorylation at Ser236 by CK2 seems to play a significant role in cell adhesion and might initiate new insights in the CK2 and EB1 family protein association.
Schwarz, Kerstin ; Aschenbrenner, Frank ; Rüster, Brigitte Inge ; Kampfmann, Manuela ; Komor, Martina ; Hofmann, Wolf-Karsten ; Ruthardt, Martin ; Henschler, Reinhard ; Bug, Gesine
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic hematopoietic progenitor cells (HPC) to fibronectin and migration in a three-dimensional stromal cell model. Here, we identified the Ras GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) as a target gene of Rho GTPases and analysed its role in regulating HPC motility. Overexpression of G3BP significantly enhanced adhesion of murine 32D HPC to fibronectin and human umbilical vein endothelial cells, increased the proportion of adherent cells in a flow chamber assay and promoted cell migration in a transwell assay and a three-dimensional stromal cell model suggesting a strong impact on the cytoskeleton. Immunofluorescent staining of G3BP-overexpressing fibroblasts revealed a Rho-like phenotype characterized by formation of actin stress fibers in contrast to the Rac-like phenotype of control fibroblasts. This is the first report implicating a role for G3BP in Rho GTPase-mediated signalling towards adhesion and migration of HPC. Our results may be of clinical importance, since G3BP was found overexpressed in human cancers.
Rödel, Franz ; Martin, Daniel ; Helmke, Christina ; Balermpas, Panagiotis ; Fokas, Emmanouil ; Wieland, Ulrike ; Rave-Fränk, Margret ; Kitz, Julia ; Matthess, Yves ; Raab, Monika ; Strebhardt, Klaus ; Rödel, Claus
We have recently shown that caspase-8 is a new substrate of Polo-like kinase 3 (Plk3) that phosphorylates the protein on residue T273 thereby promoting its pro-apoptotic function. In the present study we aimed to investigate the clinical relevance of Plk3 expression and phosphorylation of caspase-8 at T273 in patients with anal squamous cell carcinoma (SSC) treated with 5-fluorouracil and mitomycin C-based chemoradiotherapy (CRT). Immunohistochemical detection of the markers was performed in pretreatment biopsy specimens of 95 patients and was correlated with clinical/histopathologic characteristics including HPV-16 virus load/p16INK4a expression and cumulative incidence of local and distant failure, cancer specific survival (CSS), and overall survival (OS). We observed significant positive correlations between Plk3 expression, pT273 caspase-8 signal, and levels of HPV-16 virus DNA load/p16INK4a detection. Patients with high scores of Plk3 and pT273 caspase-8 showed increased local control (p = 0.011; p = 0.001), increased CSS (p = 0.011; p = 0.013) and OS (p = 0.024; p = 0.001), while the levels of pT273 caspase-8 were significantly associated (p = 0.033) with distant metastases. In multivariate analyses Plk3 expression remained significant for local failure (p = 0.018), CSS (p = 0.016) and OS (p = 0.023). Moreover, a combined HPV16 DNA load and Plk3 or pT273 caspase-8 variable revealed a significant correlation to decreased local failure (p = 0.001; p = 0.009), increased CSS (p = 0.016; p = 0.023) and OS (p = 0.003; p = 0.003). In conclusion these data indicate that elevated levels of Plk3 and pT273 caspase-8 are correlated with favorable clinical outcome in patients with anal SCC treated with concomitant CRT.
Rose, Diana ; Gunthe, Sachin S. ; Jurányi, Zsófia ; Gysel, Martin ; Frank, Göran P. ; Schneider, Johannes ; Curtius, Joachim ; Pöschl, Ulrich
As part of the CLACE-6 campaign we performed size-resolved CCN measurements for a~supersaturation range of S = 0.079 % to 0.66% at the high-alpine research station Jungfraujoch, Switzerland, in March~2007. The derived effective hygroscopicity parameter κ describing the influence of particle composition on CCN activity was on average 0.23–0.30 for Aitken (50–100 nm) and 0.32–0.43 for accumulation mode particles (100–200 nm). The campaign average value of κ = 0.3 is similar to the average value of κ for other continental locations. When air masses came from southeasterly directions crossing the Po Valley in Italy, particles were much more hygroscopic (κ ≈ 0.42) due to large sulfate mass fractions. The κ values obtained at S = 0.079 % exhibited a good negative correlation with the organic mass fractions derived from PM1 aerosol mass spectrometer (AMS) measurements. Applying a simple mixing rule the organic and inorganic mass fractions observed by the AMS could be used to reproduce the temporal fluctuations of the hygroscopicity of accumulation mode particles quite well.
We show how during a cloud event the aerosol particles were activated as cloud droplets and then removed from the air by precipitation leaving behind only a small amount of accumulation mode particles consisting mainly of weakly CCN-active particles, most likely externally mixed unprocessed soot particles.
During the campaign we had the opportunity to directly compare two DMT CCN counters for a certain time. The total CCN concentration (NCCN,tot) obtained by the two instruments at equal supersaturations agreed well for both possible operating modes: detecting NCCN,tot directly by sampling the polydisperse aerosol with the CCNC, or indirectly by combining size-resolved measurements of the activated fraction with parallel measurements of the particle size distribution (e.g., by SMPS). However, some supersaturation setpoints differed between the two CCNCs by as much as 20% after applying the instrument calibrations, which resulted in differences of the corresponding NCCN,tot of up to 50%. This emphasizes that it is extremely important to carefully calibrate the supersaturation of the instrument, especially at low S.
Helling, Bianca ; König, Martin ; Dälken, Benjamin ; Engling, Andre ; Krömer, Wolfgang ; Heim, Katharina ; Wallmeier, Holger ; Haas, Jürgen ; Wildemann, Brigitte ; Fritz, Brigitte ; Jonuleit, Helmut ; Kubach, Jan ; Dingermann, Theodor ; Radeke, Heinfried H. ; Osterroth, Frank ; Uherek, Christoph ; Czeloth, Niklas ; Schüttrumpf, Jörg
CD4+CD25+ regulatory T cells (Tregs) represent a specialized subpopulation of T cells, which are essential for maintaining peripheral tolerance and preventing autoimmunity. The immunomodulatory effects of Tregs depend on their activation status. Here we show that, in contrast to conventional anti-CD4 monoclonal antibodies (mAbs), the humanized CD4-specific monoclonal antibody tregalizumab (BT-061) is able to selectively activate the suppressive properties of Tregs in vitro. BT-061 activates Tregs by binding to CD4 and activation of signaling downstream pathways. The specific functionality of BT-061 may be explained by the recognition of a unique, conformational epitope on domain 2 of the CD4 molecule that is not recognized by other anti-CD4 mAbs. We found that, due to this special epitope binding, BT-061 induces a unique phosphorylation of T-cell receptor complex-associated signaling molecules. This is sufficient to activate the function of Tregs without activating effector T cells. Furthermore, BT-061 does not induce the release of pro-inflammatory cytokines. These results demonstrate that BT-061 stimulation via the CD4 receptor is able to induce T-cell receptor-independent activation of Tregs. Selective activation of Tregs via CD4 is a promising approach for the treatment of autoimmune diseases where insufficient Treg activity has been described. Clinical investigation of this new approach is currently ongoing.
Batenburg, Sietske J. ; Voigt, Silke ; Friedrich, Oliver ; Osborne, Anne ; Bornemann, André ; Klein, Tina ; Pérez-Díaz, Lucia ; Frank, Martin
During the Late Cretaceous and early Cenozoic the Earth experienced prolonged climatic cooling most likely caused by decreasing volcanic activity and atmospheric CO2 levels. However, the causes and mechanisms of subsequent major global warming culminating in the late Paleocene to Eocene greenhouse climate remain enigmatic. We present deep and intermediate water Nd-isotope records from the North and South Atlantic to decipher the control of the opening Atlantic Ocean on ocean circulation and its linkages to the evolution of global climate. The marked convergence of Nd-isotope signatures 59 million years ago indicates a major intensification of deep-water exchange between the North and South Atlantic, which coincided with the turning point of deep-water temperatures towards early Paleogene warming. We propose that this intensification of Atlantic overturning circulation in concert with increased atmospheric CO2 from continental rifting marked a climatic tipping point contributing to a more efficient distribution of heat over the planet.
Muth, Christiane ; Uhlmann, Lorenz ; Haefeli, Walter E. ; Rochon, Justine ; Akker, J. M. van den ; Perera, Rafael ; Güthlin, Corina ; Beyer, Martin ; Oswald, Frank ; Valderas-Martínez, José María ; Knottnerus, André J. ; Gerlach, Ferdinand M. ; Harder, Sebastian
Objectives: Investigate the effectiveness of a complex intervention aimed at improving the appropriateness of medication in older patients with multimorbidity in general practice.
Design: Pragmatic, cluster randomised controlled trial with general practice as unit of randomisation.
Setting: 72 general practices in Hesse, Germany.
Participants: 505 randomly sampled, cognitively intact patients (≥60 years, ≥3 chronic conditions under pharmacological treatment, ≥5 long-term drug prescriptions with systemic effects); 465 patients and 71 practices completed the study.
Interventions: Intervention group (IG): The healthcare assistant conducted a checklist-based interview with patients on medication-related problems and reconciled their medications. Assisted by a computerised decision support system, the general practitioner optimised medication, discussed it with patients and adjusted it accordingly. The control group (CG) continued with usual care.
Outcome measures: The primary outcome was a modified Medication Appropriateness Index (MAI, excluding item 10 on cost-effectiveness), assessed in blinded medication reviews and calculated as the difference between baseline and after 6 months; secondary outcomes after 6 and 9 months’ follow-up: quality of life, functioning, medication adherence, and so on.
Results: At baseline, a high proportion of patients had appropriate to mildly inappropriate prescriptions (MAI 0–5 points: n=350 patients). Randomisation revealed balanced groups (IG: 36 practices/252 patients; CG: 36/253). Intervention had no significant effect on primary outcome: mean MAI sum scores decreased by 0.3 points in IG and 0.8 points in CG, resulting in a non-significant adjusted mean difference of 0.7 (95% CI −0.2 to 1.6) points in favour of CG. Secondary outcomes showed non-significant changes (quality of life slightly improved in IG but continued to decline in CG) or remained stable (functioning, medication adherence).
Conclusions: The intervention had no significant effects. Many patients already received appropriate prescriptions and enjoyed good quality of life and functional status. We can therefore conclude that in our study, there was not enough scope for improvement.
Trial registration number: ISRCTN99526053. NCT01171339; Results.
Sens, Alena ; Rischke, Samuel ; Hahnefeld, Lisa Katharina ; Dorochow, Erika ; Schäfer, Stephan Martin Gastón Helmut Johannes ; Thomas, Dominique Jeanette ; Köhm, Michaela ; Geisslinger, Gerd ; Behrens, Frank ; Gurke, Robert
The emerging disciplines of lipidomics and metabolomics show great potential for the discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling procedures are critical because several analytes are prone to ex vivo distortions during sample collection. To test how the intermediate storage temperature and storage period of plasma samples from K3EDTA whole-blood collection tubes affect analyte concentrations, we assessed samples from non-fasting healthy volunteers (n = 9) for a broad spectrum of metabolites, including lipids and lipid mediators, using a well-established LC-MS-based platform. We used a fold change-based approach as a relative measure of analyte stability to evaluate 489 analytes, employing a combination of targeted LC-MS/MS and LC-HRMS screening. The concentrations of many analytes were found to be reliable, often justifying less strict sample handling; however, certain analytes were unstable, supporting the need for meticulous processing. We make four data-driven recommendations for sample-handling protocols with varying degrees of stringency, based on the maximum number of analytes and the feasibility of routine clinical implementation. These protocols also enable the simple evaluation of biomarker candidates based on their analyte-specific vulnerability to ex vivo distortions. In summary, pre-analytical sample handling has a major effect on the suitability of certain metabolites as biomarkers, including several lipids and lipid mediators. Our sample-handling recommendations will increase the reliability and quality of samples when such metabolites are necessary for routine clinical diagnosis.
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
(2008)
Holdener, Martin ; Hintermann, Edith ; Bayer, Monika ; Rhode, Antje ; Rodrigo, Evelyn ; Hintereder, Gudrun ; Johnson, Eric F. ; Gonzalez, Frank J. ; Pfeilschifter, Josef ; Manns, Michael P. ; Herrath, Matthias G. von ; Christen, Urs
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection by liver-tropic viruses is one possibility for the breakdown of self-tolerance. Therefore, we infected mice with adenovirus Ad5 expressing human cytochrome P450 2D6 (Ad-2D6). Ad-2D6–infected mice developed persistent autoimmune liver disease, apparent by cellular infiltration, hepatic fibrosis, “fused” liver lobules, and necrosis. Similar to type 2 AIH patients, Ad-2D6–infected mice generated type 1 liver kidney microsomal–like antibodies recognizing the immunodominant epitope WDPAQPPRD of cytochrome P450 2D6 (CYP2D6). Interestingly, Ad-2D6–infected wild-type FVB/N mice displayed exacerbated liver damage when compared with transgenic mice expressing the identical human CYP2D6 protein in the liver, indicating the presence of a stronger immunological tolerance in CYP2D6 mice. We demonstrate for the first time that infection with a virus expressing a natural human autoantigen breaks tolerance, resulting in a chronic form of severe, autoimmune liver damage. Our novel model system should be instrumental for studying mechanisms involved in the initiation, propagation, and precipitation of virus-induced autoimmune liver diseases.
Simon, Thorsten ; Hero, Barbara ; Faldum, Andreas ; Handgretinger, Rupert ; Schrappe, Martin ; Klingebiel, Thomas ; Berthold, Frank
Background: The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy is still discussed controversial. We applied metronomic chemotherapy in the prospective NB90 trial and monoclonal anti-GD2-antibody (MAB) ch14.18 in the NB97 trial. Here, we present the long term outcome data of the patient cohort. Methods: A total of 334 stage 4 neuroblastoma patients one year or older were included. All patients successfully completed the induction therapy. In the NB90 trial, 99 patients received at least one cycle of the oral maintenance chemotherapy (NB90 MT, 12 alternating cycles of oral melphalan/etoposide and vincristine/cyclophosphamide). In the NB97 trial, 166 patients commenced the MAB ch14.18 consolidation therapy (six cycles over 12 months). Patients who received no maintenance therapy according to the NB90 protocol or by refusal in NB97 (n = 69) served as controls. Results: The median observation time was 11.11 years. The nine-year event-free survival rates were 41 ± 4%, 31 ± 5%, and 32 ± 6% for MAB ch14.18, NB90 MT, and no consolidation, respectively (p = 0.098). In contrast to earlier reports, MAB ch14.18 treatment improved the long-term outcome compared to no additional therapy (p = 0.038). The overall survival was better in the MAB ch14.18-treated group (9-y-OS 46 ± 4%) compared to NB90 MT (34 ± 5%, p = 0.026) and to no consolidation (35 ± 6%, p = 0.019). Multivariable Cox regression analysis revealed ch14.18 consolidation to improve outcome compared to no consolidation, however, no difference between NB90 MT and MAB ch14.18-treated patients was found. Conclusions: Follow-up analysis of the patient cohort indicated that immunotherapy with MAB ch14.18 may prevent late relapses. Finally, metronomic oral maintenance chemotherapy also appeared effective.
Kiltz, Uta ; Buschhorn-Milberger, Verena ; Albrecht, K. ; Lakomek, Heinz-Jürgen ; Lorenz, Hanns-Martin ; Rudwaleit, M. ; Schneider, M. ; Schulze-Koops, Hendrik ; Baraliakos, Xenofon ; Behrens, Frank ; Brandt-Jürgens, Jan ; Haibel, H. ; Hammel, L. ; Karberg, K. ; Kellner, H. ; Krause, Daniela Sandra ; Lange, U. ; Märker-Herrmann, E. ; Poddubnyy, Denis ; Sieper, J. ; Syrbe, Uta ; Braun, J.
Qualitätsstandards (QS) sind messbare Konstrukte, die helfen sollen, Versorgungslücken quantitativ zu erfassen, um langfristig die Versorgungsqualität zu verbessern. Die Assessment of SpondyloArthritis International Society (ASAS) hat kürzlich erstmals internationale QS für das Management von Patient*innen mit axialer Spondyloarthritis (axSpA) konsentiert und veröffentlicht. Die Deutsche Gesellschaft für Rheumatologie (DGRh) hat daraufhin beschlossen, diese Standards durch eine Gruppe von Expert*innen aus unterschiedlichen Versorgungsbereichen zu übersetzen, zu prüfen und ggf. zu übernehmen. Vor diesem Hintergrund wurden erstmals nationale QS für das Management von Patient*innen mit axSpA für Deutschland entwickelt. Hierbei wurde v. a. auf Machbarkeit und Praxisrelevanz geachtet. Letztlich wurden 9 QS definiert, mit denen die Qualität der Versorgung in Deutschland gemessen und verbessert werden kann bzw. soll.
Contreras Mostazo, Miriam Guadalupe ; Kurrle, Nina Susanne ; Casado, Marta ; Fuhrmann, Dominik Christian ; Alshamleh, Islam ; Häupl, Björn ; Martín-Sanz, Paloma ; Brüne, Bernhard ; Serve, Hubert ; Schwalbe, Harald ; Schnütgen, Frank ; Marin, Silvia ; Cascante, Marta
Tyrosine kinase inhibitors (TKIs) are currently the standard chemotherapeutic agents for the treatment of chronic myeloid leukemia (CML). However, due to TKI resistance acquisition in CML patients, identification of new vulnerabilities is urgently required for a sustained response to therapy. In this study, we have investigated metabolic reprogramming induced by TKIs independent of BCR-ABL1 alterations. Proteomics and metabolomics profiling of imatinib-resistant CML cells (ImaR) was performed. KU812 ImaR cells enhanced pentose phosphate pathway, glycogen synthesis, serine-glycine-one-carbon metabolism, proline synthesis and mitochondrial respiration compared with their respective syngeneic parental counterparts. Moreover, the fact that only 36% of the main carbon sources were utilized for mitochondrial respiration pointed to glycerol-phosphate shuttle as mainly contributors to mitochondrial respiration. In conclusion, CML cells that acquire TKIs resistance present a severe metabolic reprogramming associated with an increase in metabolic plasticity needed to overcome TKI-induced cell death. Moreover, this study unveils that KU812 Parental and ImaR cells viability can be targeted with metabolic inhibitors paving the way to propose novel and promising therapeutic opportunities to overcome TKI resistance in CML.
Peter, Antonia Sophia ; Roth, Edith ; Schulz, Sebastian R. ; Fraedrich, Kirsten ; Steinmetz, Tobit ; Damm, Dominik ; Hauke, Manuela ; Richel, Elie ; Müller-Schmucker, Sandra ; Habenicht, Katharina ; Eberlein, Valentina ; Issmail, Leila ; Uhlig, Nadja ; Dolles, Simon ; Grüner, Eva ; Peterhoff, David ; Ciesek, Sandra ; Hoffmann, Markus ; Pöhlmann, Stefan ; McKay, Paul F. ; Shattock, Robin J. ; Wölfel, Roman ; Socher, Eileen ; Wagner, Ralf ; Eichler, Jutta ; Sticht, Heinrich ; Schuh, Wolfgang ; Neipel, Frank ; Ensser, Armin ; Mielenz, Dirk Alexander ; Tenbusch, Matthias ; Winkler, Thomas H. ; Grunwald, Thomas ; Überla, Klaus Thomas ; Jäck, Hans-Martin
TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS-CoV-2 and boosting with spike protein, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. Nine antibodies neutralize SARS-CoV-2 infection at IC50 values in the subnanomolar range. ELISA-binding studies and DNA sequence analyses revealed one cluster of three clonally related neutralizing antibodies that target the receptor-binding domain and compete with the cellular receptor hACE2. A second cluster of six clonally related neutralizing antibodies bind to the N-terminal domain of the spike protein without competing with the binding of hACE2 or cluster 1 antibodies. SARS-CoV-2 mutants selected for resistance to an antibody from one cluster are still neutralized by an antibody from the other cluster. Antibodies from both clusters markedly reduced viral spread in mice transgenic for human ACE2 and protected the animals from SARS-CoV-2-induced weight loss. The two clusters of potent noncompeting SARS-CoV-2 neutralizing antibodies provide potential candidates for therapy and prophylaxis of COVID-19. The study further supports transgenic animals with a human immunoglobulin gene repertoire as a powerful platform in pandemic preparedness initiatives.
Babac, Ana ; Frank, Martin ; Pauer, Frédéric ; Litzkendorf, Svenja ; Rosenfeldt, Daniel ; Lührs, Verena ; Biehl, Lisa ; Hartz, Tobias ; Storf, Holger ; Schauer, Franziska ; Wagner, Thomas O. F. ; Schulenburg, Johann-Matthias von der
Background: Rare diseases are, by definition, very serious and chronic diseases with a high negative impact on quality of life. Approximately 350 million people worldwide live with rare diseases. The resulting high disease burden triggers health information search, but helpful, high-quality, and up-to-date information is often hard to find. Therefore, the improvement of health information provision has been integrated in many national plans for rare diseases, discussing the telephone as one access option. In this context, this study examines the need for a telephone service offering information for people affected by rare diseases, their relatives, and physicians.
Methods: In total, 107 individuals participated in a qualitative interview study conducted in Germany. Sixty-eight individuals suffering from a rare disease or related to somebody with rare diseases and 39 health care professionals took part. Individual interviews were conducted using a standardized semi-structured questionnaire. Interviews were analysed using the qualitative content analysis, triangulating patients, relatives, and health care professionals. The fulfilment of qualitative data processing standards has been controlled for.
Results: Out of 68 patients and relatives and 39 physicians, 52 and 18, respectively, advocated for the establishment of a rare diseases telephone service. Interviewees expected a helpline to include expert staffing, personal contact, good availability, low technical barriers, medical and psychosocial topics of counselling, guidance in reducing information chaos, and referrals. Health care professionals highlighted the importance of medical topics of counselling—in particular, differential diagnostics—and referrals.
Conclusions: Therefore, the need for a national rare diseases helpline was confirmed in this study. Due to limited financial resources, existing offers should be adapted in a stepwise procedure in accordance with the identified attributes.
Litzkendorf, Svenja ; Hartz, Tobias ; Göbel, Jens ; Storf, Holger ; Pauer, Frédéric ; Babac, Ana ; Lührs, Verena ; Bruckner-Tuderman, Leena ; Schauer, Franziska ; Schmidtke, Jörg ; Biehl, Lisa ; Wagner, Thomas O. F. ; Schulenburg, Johann-Matthias von der ; Frank, Martin
Background: Recently, public and political interest has focused on people living with rare diseases and their health concerns. Due to the large number of different types of rare diseases and the sizable number of patients, taking action to improve the life of those affected is gaining importance. In 2013, the federal government of Germany adopted a national action plan for rare diseases, including the call to establish a central information portal on rare diseases (Zentrales Informationsportal über seltene Erkrankungen, ZIPSE).
Objective: The objective of this study, therefore, was to conduct scientific research on how such a portal must be designed to meet the needs of patients, their families, and medical professionals, and to provide high-quality information for information seekers.
Methods: We chose a 3-step procedure to develop a needs-based prototype of a central information portal. In the first step, we determined the information needs of patients with rare diseases, their relatives, and health care professionals by means of qualitative interviews and their content-analytical evaluation. On the basis of this, we developed the basic structure of the portal. In the second step, we identified quality criteria for websites on rare diseases to ensure that the information linked with ZIPSE meets the quality demands. Therefore, we gathered existing criteria catalogs and discussed them in an expert workshop. In the third step, we implemented and tested the developed prototypical information portal.
Results: A portal page was configured and made accessible on the Web. The structure of ZIPSE was based on the findings from 108 qualitative interviews with patients, their relatives, and health care professionals, through which numerous information needs were identified. We placed particularly important areas of information, such as symptoms, therapy, research, and advisory services, on the start page. Moreover, we defined 13 quality criteria, referring to factors such as author information, creation date, and privacy, enabling links with high-quality information. Moreover, 19 users tested all the developed routines based on usability and comprehensibility. Subsequently, we improved the visual presentation of search results and other important search functions.
Conclusions: The implemented information portal, ZIPSE, provides high-quality information on rare diseases from a central point of access. By integrating the targeted groups as well as different experts on medical information during the construction, the website can assure an improved search for information for users. ZIPSE can also serve as a model for other Web-based information systems in the field of rare diseases.
Registered Report Identifier: RR1-10.2196/7425.
Gelens, Frank ; Komatsu, Misako ; Uran, Cem ; Jensen, Michael A. ; Miller, Kai J. ; Ince, Robin A. A. ; Vinck, Martin ; Canales-Johnson, Andres
An important question concerning inter-areal communication in the cortex, is whether these interactions are synergistic, i.e. convey information beyond what can be performed by isolated signals. Here, we dissociated cortical interactions sharing common information from those encoding complementary information during prediction error processing. To this end, we computed co-information, an information-theoretical measure that distinguishes redundant from synergistic information among brain signals. We analyzed auditory and frontal electrocorticography (ECoG) signals in three common awake marmosets and investigated to what extent event-related-potentials (ERP) and broadband (BB) dynamics exhibit redundancy and synergy in auditory prediction error signals. We observed multiple patterns of redundancy and synergy across the entire cortical hierarchy with distinct dynamics. The information conveyed by ERPs and BB signals was highly synergistic even at lower stages of the hierarchy in the auditory cortex, as well as between lower and higher areas in the frontal cortex. These results indicate that the distributed representations of prediction error signals across the cortical hierarchy can be highly synergistic.
Rabenhorst, Uta ; Thalheimer, Frederic Bastian ; Gerlach, Katharina ; Kijonka, Marek ; Böhm, Stefanie ; Krause, Daniela Sandra ; Vauti, Franz ; Arnold, Hans-Henning ; Schroeder, Timm ; Schnütgen, Frank ; Melchner, Harald von ; Rieger, Michael A. ; Zörnig, Martin
The ability of hematopoietic stem cells (HSCs) to self-renew is a prerequisite for the establishment of definitive hematopoiesis and life-long blood regeneration. Here, we report the single-stranded DNA-binding transcriptional regulator far upstream element (FUSE)-binding protein 1 (FUBP1) as an essential factor of HSC self-renewal. Functional inactivation of FUBP1 in two different mouse models resulted in embryonic lethal anemia at around E15.5 caused by severely diminished HSCs. Fetal and adult HSCs lacking FUBP1 revealed an HSC-intrinsic defect in their maintenance, expansion, and long-term blood reconstitution, but could differentiate into all hematopoietic lineages. FUBP1-deficient adult HSCs exhibit significant transcriptional changes, including upregulation of the cell-cycle inhibitor p21 and the pro-apoptotic Noxa molecule. These changes caused an increase in generation time and death of HSCs as determined by video-microscopy-based tracking. Our data establish FUBP1 and its recognition of single-stranded genomic DNA as an important element in the transcriptional regulation of HSC self-renewal.
Löschmann, Nadine ; Michaelis, Martin ; Rothweiler, Florian ; Zehner, Richard ; Cinatl, Jaroslav ; Voges, Yvonne ; Sharifi, Mohsen ; Riecken, Kristoffer ; Meyer, Jochen ; Deimling, Andreas von ; Fichtner, Iduna ; Ghafourian, Taravat ; Westermann, Frank ; Cinatl, Jindrich
Novel treatment options are needed for the successful therapy of patients with high-risk neuroblastoma. Here, we investigated the cyclin-dependent kinase (CDK) inhibitor SNS-032 in a panel of 109 neuroblastoma cell lines consisting of 19 parental cell lines and 90 sublines with acquired resistance to 14 different anticancer drugs. Seventy-three percent of the investigated neuroblastoma cell lines and all four investigated primary tumor samples displayed concentrations that reduce cell viability by 50% in the range of the therapeutic plasma levels reported for SNS-032 (<754 nM). Sixty-two percent of the cell lines and two of the primary samples displayed concentrations that reduce cell viability by 90% in this concentration range. SNS-032 also impaired the growth of the multidrug-resistant cisplatin-adapted UKF-NB-3 subline UKF-NB-3rCDDP1000 in mice. ABCB1 expression (but not ABCG2 expression) conferred resistance to SNS-032. The antineuroblastoma effects of SNS-032 did not depend on functional p53. The antineuroblastoma mechanism of SNS-032 included CDK7 and CDK9 inhibition-mediated suppression of RNA synthesis and subsequent depletion of antiapoptotic proteins with a fast turnover rate including X-linked inhibitor of apoptosis (XIAP), myeloid cell leukemia sequence 1 (Mcl-1), baculoviral IAP repeat containing 2 (BIRC2; cIAP-1), and survivin. In conclusion, CDK7 and CDK9 represent promising drug targets and SNS-032 represents a potential treatment option for neuroblastoma including therapy-refractory cases.
Gehara, Marcelo ; Crawford, Andrew J. ; Orrico, Victor G. D. ; Rodríguez, Ariel ; Lötters, Stefan ; Fouquet, Antoine ; Barrientos, Lucas S. ; Brusquetti, Francisco ; De la Riva, Ignacio ; Ernst, Raffael ; Gagliardi Urrutia, Giuseppe ; Glaw, Frank ; Guayasamin, Juan M. ; Hölting, Monique ; Jansen, Martin ; Kok, Philippe Jacques Robert ; Kwet, Axel ; Lingnau, Rodrigo ; Lyra, Mariana ; Moravec, Jiří ; Pombal Jr, José P. ; J. M. Rojas-Runjaic, Fernando ; Schulze, Arne ; Señaris, J. Celsa ; Solé, Mirco ; Trefaut Rodrigues, Miguel ; Twomey, Evan ; Haddad, Célio Fernando Baptista ; Vences, Miguel ; Köhler, Jörn
Species distributed across vast continental areas and across major biomes provide unique model systems for studies of biotic diversification, yet also constitute daunting financial, logistic and political challenges for data collection across such regions. The tree frog Dendropsophus minutus (Anura: Hylidae) is a nominal species, continentally distributed in South America, that may represent a complex of multiple species, each with a more limited distribution. To understand the spatial pattern of molecular diversity throughout the range of this species complex, we obtained DNA sequence data from two mitochondrial genes, cytochrome oxidase I (COI) and the 16S rhibosomal gene (16S) for 407 samples of D. minutus and closely related species distributed across eleven countries, effectively comprising the entire range of the group. We performed phylogenetic and spatially explicit phylogeographic analyses to assess the genetic structure of lineages and infer ancestral areas. We found 43 statistically supported, deep mitochondrial lineages, several of which may represent currently unrecognized distinct species. One major clade, containing 25 divergent lineages, includes samples from the type locality of D. minutus. We defined that clade as the D. minutus complex. The remaining lineages together with the D. minutus complex constitute the D. minutus species group. Historical analyses support an Amazonian origin for the D. minutus species group with a subsequent dispersal to eastern Brazil where the D. minutus complex originated. According to our dataset, a total of eight mtDNA lineages have ranges >100,000 km2. One of them occupies an area of almost one million km2 encompassing multiple biomes. Our results, at a spatial scale and resolution unprecedented for a Neotropical vertebrate, confirm that widespread amphibian species occur in lowland South America, yet at the same time a large proportion of cryptic diversity still remains to be discovered.
Abdel-Rahman, Ulf ; Margraf, Stefan ; Aybek, Tayfun ; Lögters, Tim Tobias ; Bitu-Moreno, José ; Francischetti, Ieda ; Kranert, Tilmann ; Grünwald, Frank ; Windolf, Joachim ; Moritz, Anton ; Scholz, Martin
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We now studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. Methods German landrace pigs underwent CPB (60 min myocardial ischemia; 30 min reperfusion)without (group I; n=6) or with LIM (group II; n=6). The cardiac indices (CI) and cardiac function were analyzed pre and post CPB with a Swan-Ganz catheter and the cardiac function analyzer. Neutrophil labeling with technetium, scintigraphy, and histological analyses were done to track activated neutrophils within the organs. Results LIM prevented CPB-associated increase of neutrophil counts in peripheral blood. In group I, the CI significantly declined post CPB (post: 3.26 +/- 0.31; pre: 4.05 +/- 0.45 l/min/m2; p<0.01). In group II, the CI was only slightly reduced (post: 3.86 +/- 0.49; pre 4.21 +/- 1.32 l/min/m2; p=0.23). Post CPB, the intergroup difference showed significantly higher CI values in the LIM group (p<0.05) which was in conjunction with higher pre-load independent endsystolic pressure volume relationship (ESPVR) values (group I: 1.57 +/- 0.18; group II: 1.93 +/- 0.16; p<0.001). Moreover, the systemic vascular resistance and pulmonary vascular resistance were lower in the LIM group. LIM appeared to accelerate the sequestration of hyperactivated neutrophils in the spleen and to reduce neutrophil infiltration of heart and lung. Conclusions Our data provide strong evidence that LIM improves perioperative hemodynamics and cardiac function after CPB by limiting neutrophil activity and inducing accelerated sequestration of neutrophils in the spleen.
Röllig, Christoph ; Kramer, Michael ; Gabrecht, Maria ; Hänel, Mathias ; Herbst, Regina ; Kaiser, Ulrich ; Schmitz, Norbert ; Kullmer, Johannes ; Fetscher, Sebastian ; Link, Hartmut ; Mantovani Löffler, Luisa ; Krümpelmann, Ulrich ; Neuhaus, Thomas ; Heits, Frank ; Einsele, Hermann ; Ritter, Barbara ; Bornhäuser, Martin ; Schetelig, Johannes ; Thiede, Carsten ; Mohr, Brigitte ; Schaich, Markus ; Platzbecker, Uwe ; Schäfer-Eckart, Kerstin ; Krämer, Alwin ; Berdel, Wolfgang E. ; Serve, Hubert ; Ehninger, Gerhard ; Schuler, Ulrich
Background: The combination of intermediate-dose cytarabine plus mitoxantrone (IMA) can induce high complete remission rates with acceptable toxicity in elderly patients with acute myeloid leukemia (AML). We present the final results of a randomized-controlled trial comparing IMA with the standard 7 + 3 induction regimen consisting of continuous infusion cytarabine plus daunorubicin (DA).
Patients and methods: Patients with newly diagnosed AML >60 years were randomized to receive either intermediate-dose cytarabine (1000 mg/m2 twice daily on days 1, 3, 5, 7) plus mitoxantrone (10 mg/m2 days 1–3) (IMA) or standard induction therapy with cytarabine (100 mg/m2 continuously days 1–7) plus daunorubicin (45 mg/m2 days 3–5) (DA). Patients in complete remission after DA received intermediate-dose cytarabine plus amsacrine as consolidation treatment, whereas patients after IMA were consolidated with standard-dose cytarabine plus mitoxantrone.
Results: Between February 2005 and October 2009, 485 patients were randomized; 241 for treatment arm DA and 244 for IMA; 76% of patients were >65 years. The complete response rate after DA was 39% [95% confidence interval (95% CI): 33–45] versus 55% (95% CI: 49–61) after IMA (odds ratio 1.89, P = 0.001). The 6-week early-death rate was 14% in both arms. Relapse-free survival curves were superimposable in the first year, but separated afterwards, resulting in 3-year relapse-free survival rates of 29% versus 14% in the DA versus IMA arms, respectively (P = 0.042). The median overall survival was 10 months in both arms (P = 0.513).
Conclusion: The dose escalation of cytarabine in induction therapy lead to improved remission rates in the elderly AML patients. This did not translate into a survival advantage, most likely due to differences in consolidation treatment. Thus, effective consolidation strategies need to be further explored. In combination with an effective consolidation strategy, the use of intermediate-dose cytarabine in induction may improve curative treatment for elderly AML patients.
Grillari, Johannes ; Ajuh, Paul ; Stadler, Guido ; Löscher, Marlies ; Voglauer, Regina ; Ernst, Wolfgang ; Chusainow, Janet ; Eisenhaber, Frank ; Pokar, Marion ; Fortschegger, Klaus ; Grey, Martin ; Lamond, Angus I. ; Katinger, Hermann
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing. We have used various approaches including gene complementation studies in yeast using a temperature sensitive mutant with a pleiotropic phenotype and SNEV immunodepletion from human HeLa nuclear extracts to determine its function. A human–yeast chimera was indeed capable of restoring the wild-type phenotype of the yeast mutant strain. In addition, immunodepletion of SNEV from human nuclear extracts resulted in a decrease of in vitro pre-mRNA splicing efficiency. Furthermore, as part of our analysis of protein–protein interactions within the CDC5L complex, we found that SNEV interacts with itself. The self-interaction domain was mapped to amino acids 56–74 in the protein's sequence and synthetic peptides derived from this region inhibit in vitro splicing by surprisingly interfering with spliceosome formation and stability. These results indicate that SNEV is the human orthologue of yeast PRP19, functions in splicing and that homo-oligomerization of SNEV in HeLa nuclear extract is essential for spliceosome assembly and that it might also be important for spliceosome stability.
Barucca, Gianni ; Davì, F. ; Lancioni, G. ; Mengucci, P. ; Montalto, L. ; Natali, P. P. ; Paone, N. ; Rinaldi, D. ; Scalise, L. ; Erni, W. ; Krusche, B. ; Steinacher, M. ; Walford, N. ; Cao, N. ; Liu, Z. ; Liu, C. ; Liu, B. ; Shen, X. ; Sun, S. ; Tao, J. ; Xiong, X. A. ; Zhao, G. ; Zhao, J. ; Albrecht, Malte ; Alkakhi, W. ; Bökelmann, S. ; Coen, S. ; Feldbauer, Florian ; Fink, M. ; Frech, J. ; Freudenreich, V. ; Fritsch, Miriam ; Grochowski, J. ; Hagdorn, R. ; Heinsius, Fritz-Herbert ; Held, T. ; Holtmann, Tobias ; Keshk, Iman ; Koch, H. ; Kopf, Bertram ; Kuhlmann, M. ; Kümmel, M. ; Küßner, M. ; Li, J. ; Linzen, L. ; Maldaner, Stephan ; Oppotsch, J. ; Pankonin, S. ; Pelizäus, Marc ; Pflüger, S. ; Pitka, A. ; Reher, J. ; Reicherz, G. ; Schnier, Claudius ; Steinke, M. ; Triffterer, T. ; Wenzel, C. ; Wiedner, Ulrich ; Denizli, H. ; Er, N. ; Keskin, U. ; Olgun, A. T. ; Yerlikaya, S. ; Yilmaz, A. ; Beck, R. ; Hammann, C. ; Hartmann, J. ; Ketzer, Bernhard ; Müllers, J. ; Rossbach, M. ; Salisbury, B. ; Schmidt, Christian Joachim ; Thoma, U. ; Urban, M. ; Bianconi, A. ; Bragadireanu, Mario ; Pantea, D. ; Domagala, M. ; Filo, G. ; Lisowski, E. ; Lisowski, F. ; Michałek, M. ; Poznański, P. ; Płażek, J. ; Korcyl, K. ; Kozela, A. ; Lebiedowicz, P. ; Pysz, K. ; Schäfer, W. ; Szczurek, A. ; Firlej, M. ; Fiutowski, T. ; Idzik, M. ; Moron, J. ; Swientek, K. ; Terlecki, P. ; Korcyl, G. ; Lalik, R. ; Malige, A. ; Moskal, P. ; Nowakowski, K. ; Przygoda, W. ; Rathod, N. ; Rudy, Z. ; Salabura, P. ; Smyrski, J. ; Augustin, I. ; Böhm, R. ; Lehmann, I. ; Schmitt, L. ; Varentsov, V. ; Al-Turany, Mohammad ; Belias, A. ; Deppe, H. ; Dzhygadlo, R. ; Flemming, H. ; Gerhardt, A. ; Götzen, Klaus ; Heinz, Andreas ; Jiang, P. ; Karabowicz, R. ; Koch, S. ; Kurilla, U. ; Lehmann, D. ; Lühning, J. ; Lynen, U. ; Orth, H. ; Peters, Klaus ; Saito, T. ; Schepers, G. ; Schmidt, C. J. ; Schwarz, C. ; Schwiening, J. ; Täschner, Alexander ; Traxler, M. ; Voss, B. ; Wieczorek, P. ; Abazov, V. ; Alexeev, G. ; Arefiev, V. A. ; Astakhov, V. ; Barabanov, M. Yu. ; Batyunya, B. V. ; Dodokhov, V. Kh. ; Efremov, A. ; Fechtchenko, A. ; Galoyan, A. ; Golovanov, G. ; Koshurnikov, E. K. ; Lobanov, Y. Yu. ; Olshevskiy, A. G. ; Piskun, A. A. ; Samartsev, A. ; Shimanski, S. ; Skachkov, N. B. ; Skachkova, A. N. ; Strokovsky, E. A. ; Tokmenin, V. ; Uzhinsky, V. ; Verkheev, A. ; Vodopianov, A. ; Zhuravlev, N. I. ; Branford, D. ; Watts, D. ; Böhm, M. ; Eyrich, W. ; Lehmann, A. ; Miehling, D. ; Pfaffinger, M. ; Quin, N. ; Robison, L. ; Seth, K. ; Xiao, T. ; Bettoni, Diego ; Ali, A. ; Hamdi, A. ; Himmelreich, Mathilde ; Krebs, M. ; Nakhoul, S. ; Nerling, Frank ; Belousov, A. ; Kisel, Ivan ; Kozlov, Grigory ; Pugach, M. ; Zyzak, Maksym ; Bianchi, Nicola ; Gianotti, Paola ; Lucherini, V. ; Bracco, G. ; Bettner, Y. ; Bodenschatz, S. ; Brinkmann, K. T. ; Brück, L. ; Diehl, S. ; Dormenev, V. ; Düren, M. ; Erlen, T. ; Föhl, K. ; Hahn, C. ; Hayrapetyan, A. ; Hofmann, J. ; Kegel, S. ; Kesselkaul, M. ; Köseoglu, I. ; Kripko, A. ; Kühn, Wolfgang ; Lange, Jens Sören ; Metag, V. ; Moritz, M. ; Nanova, M. ; Novotny, R. ; Orsich, P. ; Pereira-de-Lira, J. ; Peter, M. ; Sachs, M. ; Schmidt, M. ; Schubert, R. ; Stenzel, H. ; Straube, M. ; Strickert, M. ; Thöring, U. ; Wasem, T. ; Wohlfahrt, B. ; Zaunick, H. G. ; Tomasi-Gustafsson, E. ; Glazier, D. ; Ireland, D. ; Seitz, B. ; Deepak, P. N. ; Kulkarni, A. ; Kappert, R. ; Kavatsyuk, Myroslav O. ; Loehner, H. ; Messchendorp, Johannes Gerhardus ; Rodin, Viktor ; Schakel, P. ; Vejdani, S. ; Dutta, K. ; Kalita, K. ; Huang, G. ; Liu, D. ; Peng, H. ; Qi, H. ; Sun, Y. ; Zhou, X. ; Kunze, M. ; Azizi, K. ; Tavukoglu, Z. ; Derichs, A. ; Dosdall, R. ; Esmail, W. ; Gillitzer, A. ; Goldenbaum, F. ; Grunwald, D. ; Jokhovets, L. ; Kannika, J. ; Kulessa, P. ; Orfanitski, S. ; Pérez Andrade, G. ; Prasuhn, D. ; Prencipe, E. ; Pütz, J. ; Ritman, J. ; Rosenthal, E. ; Schadmand, S. ; Schmitz, R. ; Scholl, A. ; Sefzick, T. ; Serdyuk, V. ; Stockmanns, T. ; Veretennikov, D. ; Wintz, P. ; Wüstner, P. ; Xu, H. ; Zhou, Y. ; Cao, X. ; Hu, Q. ; Li, Z. ; Li, H. ; Liang, Y. ; Ma, X. ; Rigato, V. ; Isaksson, L. ; Achenbach, P. ; Corell, O. ; Denig, Achim ; Distler, M. ; Hoek, M. ; Lauth, W. ; Leithoff, H. H. ; Liu, Z. ; Merkel, H. ; Müller, U. ; Pochodzalla, J. ; Schlimme, S. ; Sfienti, C. ; Thiel, M. ; Zambrana, M. ; Ahmed, Samer ; Bleser, S. ; Bölting, M. ; Capozza, L. ; Dbeyssi, A. ; Ehret, A. ; Klasen, R. ; Kliemt, Ralf ; Maas, F. ; Motzko, C. ; Noll, O. ; Piñeiro, D. Rodríguez ; Schupp, F. ; Steinen, M. ; Wolff, S. ; Zimmermann, I. ; Fedorov, A. ; Kazlou, D. ; Korzhik, M. ; Missevitch, O. ; Balanutsa, P. ; Chernetsky, V. ; Demekhin, A. ; Dolgolenko, A. ; Fedorets, P. ; Gerasimov, A. ; Golubev, A. ; Goryachev, V. ; Kantsyrev, Alexey V. ; Kirin, D. Y. ; Kristi, N. ; Ladygina, E. ; Luschevskaya, E. ; Matveev, V. A. ; Panjushkin, V. ; Stavinskiy, A. V. ; Balashoff, A. ; Boukharov, A. ; Malyshev, O. ; Basant, K. N. ; Kumawat, H. ; Roy, B. ; Saxena, Alok ; Yogesh, S. ; Bonaventura, D. ; Brand, P. ; Fritzsch, C. ; Grieser, S. ; Hargens, C. ; Hergemöller, A. K. ; Hetz, B. ; Hüsken, Nils ; Kellers, J. ; Khoukaz, Alfons ; Mannweiler, C. ; Vestrick, S. ; Bumrungkoh, D. ; Herold, Christoph ; Khosonthongkee, K. ; Kobdaj, Chinorat ; Limphirat, A. ; Manasatitpong, K. ; Nasawad, T. ; Pongampai, S. ; Simantathammakul, T. ; Srisawad, P. ; Wongprachanukul, N. ; Yan, Y. ; Yu, C. ; Zhang, X. ; Zhu, W. ; Blinov, A. E. ; Kononov, S. ; Kravchenko, E. A. ; Antokhin, E. ; Barnyakov, A. Yu. ; Beloborodov, K. ; Blinov, V. E. ; Kuyanov, I. A. ; Pivovarov, S. ; Pyata, E. ; Tikhonov, Y. ; Hunter, G. ; Lattery, M. ; Pace, H. ; Boca, Gianluigi ; Duda, D. ; Finger, M. ; Finger, M. ; Kveton, A. ; Pesek, M. ; Peskova, M. ; Prochazka, I. ; Slunecka, M. ; Volf, M. ; Gallus, P. ; Jary, V. ; Korchak, O. ; Marcisovsky, M. ; Neue, G. ; Novy, J. ; Tomasek, L. ; Tomasek, M. ; Virius, M. ; Vrba, V. ; Abramov, V. ; Bukreeva, S. ; Chernichenko, S. ; Derevschikov, A. ; Ferapontov, V. ; Goncharenko, Y. ; Levin, A. ; Maslova, E. ; Melnik, Y. ; Meščanin, Aleksei P. ; Minaev, N. ; Mochalov, V. ; Moiseev, V. ; Morozov, D. ; Nogach, L. ; Poslavskiy, S. ; Ryazantsev, A. ; Ryzhikov, S. ; Semenov, P. ; Shein, I. ; Uzunian, A. ; Vasiliev, Andrey ; Yakutin, A. ; Roy, U. ; Yabsley, B. ; Belostotski, S. ; Fedotov, G. ; Gavrilov, G. ; Izotov, A. ; Manaenkov, S. ; Miklukho, O. ; Zhdanov, A. ; Atac, A. ; Bäck, T. ; Cederwall, B. ; Makonyi, K. ; Preston, M. ; Tegner, P. E. ; Wölbing, D. ; Gandhi, K. ; Rai, A. K. ; Godre, S. ; Crede, V. ; Dobbs, S. ; Eugenio, P. ; Lersch, D. ; Calvo, D. ; De Remigis, P. ; Filippi, A. ; Mazza, G. ; Rivetti, Angelo ; Wheadon, R. ; Bussa, M. P. ; Spataro, Stefano ; Iazzi, F. ; Lavagno, A. ; Martin, A. ; Akram, A. ; Calen, H. ; Ikegami Andersson, Walter ; Johansson, Tord ; Kupsc, Andrzej ; Marciniewski, P. ; Papenbrock, Michael ; Regina, J. ; Rieger, J. ; Schönning, K. ; Wolke, M. ; Pothodi Chackara, V. ; Chlopik, A. ; Kesik, G. ; Melnychuk, D. ; Tarasiuk, J. ; Wojciechowski, M. ; Wronka, S. ; Zwieglinski, B. ; Amsler, C. ; Bühler, Paul ; Marton, J. ; Nalti, W. ; Steinschaden, D. ; Widmann, Eberhard ; Zimmermann, S. ; Zmeskal, Johann
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
Measurement of cold nuclear matter effects for inclusive J/ψ in p+Au collisions at √sNN = 200 GeV
(2022)
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhagat, P. ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bunzarov, Ivan ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, X. ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, P. ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, E. ; Dunlop, James C. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F.M. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Y. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fu, C. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Ghimire, N. ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Han, Y. ; Harabasz, Szymon ; Harasty, M.D. ; Harris, John W. ; Harrison, H. ; He, S. ; He, W. ; He, X.H. ; He, Y. ; Heppelmann, Steven Francis ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, Y. ; Huang, H. ; Huang, H.Z. ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Y. ; Jia, J. ; Jiang, K. ; Ju, X. ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H.S. ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, S. ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Y.H. ; Li, C. ; Li, C. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Loyd, E. ; Lukow, N.S. ; Luo, X.F. ; Ma, L. ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Mukherjee, Ayon ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pan, Jinjin ; Pandav, A. ; Pandey, Ashutosh Kumar ; Panebratsev, Yuri ; Parfenov, P. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Pokhrel, B.R. ; Ponimatkin, G. ; Porter, Jeffrey Brent ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, M. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roy, D. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, A.K. ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, S. ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, T. ; Sheikh, Ashik Ikbal ; Shen, D.Y. ; Shi, S.S. ; Shi, Y. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Skoby, M.J. ; Smirnov, Nikolai ; Söhngen, Y. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Sweger, Z.W. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, T. ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Z. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, P.C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z.G. ; Xie, G. ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Q.H. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, C. ; Zhang, D. ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhou, C. ; Zhu, X. ; Zurek, Marian ; Zyzak, Maksym
Measurement by the STAR experiment at RHIC of the cold nuclear matter (CNM) effects experienced by inclusive J/ψ at mid-rapidity in 0-100% p+Au collisions at √sNN = 200 GeV is presented. Such effects are quantified utilizing the nuclear modification factor, RpAu, obtained by taking a ratio of J/ψ yield in p+Au collisions to that in p+p collisions scaled by the number of binary nucleon-nucleon collisions. The differential J/ψ yield in both p+p and p+Au collisions is measured through the dimuon decay channel, taking advantage of the trigger capability provided by the Muon Telescope Detector in the RHIC 2015 run. Consequently, the J/ψ RpAu is derived within the transverse momentum (pT) range of 0 to 10 GeV/c. A suppression of approximately 30% is observed for pT < 2 GeV/c, while J/ψ RpAu becomes compatible with unity for pT greater than 3 GeV/c, indicating the J/ψ yield is minimally affected by the CNM effects at high pT. Comparison to a similar measurement from 0-20% central Au+Au collisions reveals that the observed strong J/ψ suppression above 3 GeV/c is mostly due to the hot medium effects, providing strong evidence for the formation of the quark-gluon plasma in these collisions. Several model calculations show qualitative agreement with the measured J/ψ RpAu, while their agreement with the J/ψ yields in p+p and p+Au collisions is worse.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhagat, P. ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bunzarov, Ivan ; Butterworth, Joseph ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, X. ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, P. ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, E. ; Dunlop, James C. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F.M. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Y. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fu, C. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Ghimire, N. ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Han, Y. ; Harabasz, Szymon ; Harasty, M.D. ; Harris, John W. ; Harrison, H. ; He, S. ; He, W. ; He, X.H. ; He, Y. ; Heppelmann, Steven Francis ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, Y. ; Huang, H. ; Huang, H.Z. ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Y. ; Jia, J. ; Jiang, K. ; Ju, X. ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H.S. ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Y.H. ; Li, C. ; Li, C. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Loyd, E. ; Lukow, N.S. ; Luo, X.F. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Mukherjee, Ayon ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pan, Jinjin ; Pandav, A. ; Pandey, Ashutosh Kumar ; Panebratsev, Yuri ; Parfenov, P. ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Pokhrel, B.R. ; Ponimatkin, G. ; Porter, Jeffrey Brent ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, M. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roy, D. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, S. ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, T. ; Sheikh, Ashik Ikbal ; Shen, D. ; Shi, S.S. ; Shi, Y. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Skoby, M.J. ; Smirnov, Nikolai ; Söhngen, Y. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Sweger, Z.W. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, T. ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Z. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, P.C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z.G. ; Xie, G. ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Q.H. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, C. ; Zhang, D. ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhou, C. ; Zhou, You ; Zhu, X. ; Zurek, Marian ; Zyzak, Maksym
We report on the measurements of directed flow v1 and elliptic flow v2 for hadrons (π±, K ±, K0 S , p, φ, Λ and ) from Au+Au collisions at √sN N = 3 GeV and v2 for (π±, K ±, p and p) at 27 and 54.4 GeV with the STAR experiment. While at the two higher energy midcentral collisions the numberof-constituent-quark (NCQ) scaling holds, at 3 GeV the v2 at midrapidity is negative for all hadrons and the NCQ scaling is absent. In addition, the v1 slopes at midrapidity for almost all observed hadrons are found to be positive, implying dominant repulsive baryonic interactions. The features of negative v2 and positive v1 slope at 3 GeV can be reproduced with a baryonic mean-field in transport model calculations. These results imply that the medium in such collisions is likely characterized by baryonic interactions.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, A. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Averichev, Georgy S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhagat, P. ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, P. ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, E. ; Dunlop, James C. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F.M. ; Fazio, Salvatore ; Feng, C.J. ; Feng, Y. ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fu, C. ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Ghimire, N. ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamed, Ahmed M. ; Han, Y. ; Harabasz, Szymon ; Harasty, M.D. ; Harris, John W. ; Harrison, H. ; He, S. ; He, W. ; He, X.H. ; He, Y. ; Heppelmann, Steven Francis ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, C. ; Hu, Q. ; Hu, Y. ; Huang, H. ; Huang, H.Z. ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, D. ; Isshiki, M. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Y. ; Jia, J. ; Jiang, K. ; Ju, X. ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H.S. ; Kočenda, L. M. ; Korobitsin, A. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, S. ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Y.H. ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Loyd, E. ; Lu, T. ; Lukow, N.S. ; Luo, X.F. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Manukhov, S.L. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Mukherjee, Ayon ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Okubo, K. ; Page, Brian S. ; Pak, Robert ; Pan, Jinjin ; Pandav, A. ; Pandey, Ashutosh Kumar ; Panebratsev, Yuri ; Parfenov, P. ; Paul, A. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pinsky, Lawrence ; Pluta, Jan Marian ; Pokhrel, B.R. ; Porter, Jeffrey Brent ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, M. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roy, D. ; Ruan, Lijuan ; Sahoo, A.K. ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Samigullin, Eduard ; Sandweiss, Jack H. ; Sato, S. ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, T. ; Sharma, R. ; Sheikh, Ashik Ikbal ; Shen, D.Y. ; Shi, S.S. ; Shi, Y. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Singh, Jagbir ; Singha, Subhash ; Sinha, P. ; Skoby, M.J. ; Smirnov, Nikolai ; Söhngen, Y. ; Solyst, William ; Song, Y. ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Sweger, Z.W. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, T. ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Z. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, P.C. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z.G. ; Xie, G. ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Q.H. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, C. ; Zhang, D. ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, F. ; Zhao, J. ; Zhao, M. ; Zhou, C. ; Zhou, You ; Zhu, X. ; Zurek, Marian ; Zyzak, Maksym
In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in √sNN = 3 GeV Au+Au collisions. In this paper, we report measurements of the first- and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in √sNN = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC.
Queck, Alexander David Roger ; Bode, Hannah ; Uschner, Frank Erhard ; Brol, Maximilian ; Graf, Christiana ; Schulz, Martin ; Jansen, Christian ; Praktiknjo, Michael ; Schierwagen, Robert ; Klein, Sabine ; Trautwein, Christian ; Wasmuth, Hermann E. ; Berres, Marie-Luise ; Trebicka, Jonel ; Lehmann, Jennifer
Background and Aims: Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP-1 is a readout of macrophage activation. While inflammation is a major driver of liver disease progression, the origin and role of circulating MCP-1 as a biomarker remains unclear.
Methods: Hepatic CC-chemokine ligand 2 (CCL2) expression and F4/80 staining for Kupffer cells were measured and correlated in a mouse model of chronic liver disease (inhalative CCl4 for 7 weeks). Next, hepatic RNA levels of CCL2 were measured in explanted livers of 39 patients after transplantation and correlated with severity of disease. Changes in MCP-1 were further evaluated in a rat model of experimental cirrhosis and acute-on-chronic liver failure (ACLF). Finally, we analyzed portal and hepatic vein levels of MCP-1 in patients receiving transjugular intrahepatic portosystemic shunt insertion for complications of portal hypertension.
Results: In this mouse model of fibrotic hepatitis, hepatic expression of CCL2 (P = 0.009) and the amount of F4/80 positive cells in the liver (P < 0.001) significantly increased after induction of hepatitis by CCl4 compared to control animals. Moreover, strong correlation of hepatic CCL2 expression and F4/80 positive cells were seen (P = 0.023). Furthermore, in human liver explants, hepatic transcription levels of CCL2 correlated with the MELD score of the patients, and thus disease severity (P = 0.007). The experimental model of ACLF in rats revealed significantly higher levels of MCP-1 plasma (P = 0.028) and correlation of hepatic CCL2 expression (R = 0.69, P = 0.003). Particularly, plasma MCP-1 levels did not correlate with peripheral blood monocyte CCL2 expression. Finally, higher levels of MCP-1 were observed in the hepatic compared to the portal vein (P = 0.01) in patients receiving TIPS. Similarly, a positive correlation of MCP-1 with Child-Pugh score was observed (P = 0.018). Further, in the presence of ACLF, portal and hepatic vein levels of MCP-1 were significantly higher compared to patients without ACLF (both P = 0.039).
Conclusion: Circulating levels of MCP-1 mainly derive from the injured liver and are associated with severity of liver disease. Therefore, liver macrophages contribute significantly to disease progression. Circulating MCP-1 may reflect the extent of hepatic macrophage activation.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bai, Xiaozhi ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Steven Francis ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Holub, Lukáš ; Horvat, S. ; Huang, X. ; Huang, B. ; Huang, Shengli ; Huang, H.Z. ; Huang, T. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, J. ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Kramárik, Lukáš ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Shyam ; Kumar, Lokesh ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, Xiaomei ; Li, C. ; Li, W. ; Li, Y. ; Liang, Y. ; Lidrych, J. ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, F. ; Liu, P. ; Liu, H. ; Liu, Y. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, X. ; Luo, S. ; Ma, G.L. ; Ma, Yu-Gang ; Ma, L. ; Ma, R. ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mayes, D. ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Nasim, Md. ; Negrete, J.D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shen, F. ; Shi, S.S. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, Y. ; Sun, X. ; Sun, X.M. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, G. ; Wang, Y. ; Wang, F. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, Q.H. ; Xu, Z. ; Xu, J. ; Xu, Y.F. ; Xu, N. ; Yang, S. ; Yang, C. ; Yang, Q. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, Zuman ; Zhang, L. ; Zhang, Y. ; Zhang, X.P. ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, J. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, Z. ; Zhu, X. ; Zyzak, Maksym
New measurements of directed flow for charged hadrons, characterized by the Fourier coefficient v1, are presented for transverse momenta pT, and centrality intervals in Au+Au collisions recorded by the STAR experiment for the center-of-mass energy range √sN N = 7.7–200 GeV. The measurements underscore the importance of momentum conservation, and the characteristic dependencies on √sN N , centrality and pT are consistent with the expectations of geometric fluctuations generated in the initial stages of the collision, acting in concert with a hydrodynamic-like expansion. The centrality and pT dependencies of veven 1 , as well as an observed similarity between its excitation function and that for v3, could serve as constraints for initial-state models. The veven 1 excitation function could also provide an important supplement to the flow measurements employed for precision extraction of the temperature dependence of the specific shear viscosity.
Gelens, Frank ; Äijälä, Juho ; Roberts, Louis ; Komatsu, Misako ; Uran, Cem ; Jensen, Michael A. ; Miller, Kai J. ; Ince, Robin A. A. ; Garagnani, Max ; Vinck, Martin ; Canales-Johnson, Andres
An important question concerning inter-areal communication in the cortex is whether these interactions are synergistic, i.e. brain signals can either share common information (redundancy) or they can encode complementary information that is only available when both signals are considered together (synergy). Here, we dissociated cortical interactions sharing common information from those encoding complementary information during prediction error processing. To this end, we computed co-information, an information-theoretical measure that distinguishes redundant from synergistic information among brain signals. We analyzed auditory and frontal electrocorticography (ECoG) signals in five common awake marmosets performing two distinct auditory oddball tasks and investigated to what extent event-related potentials (ERP) and broadband (BB) dynamics encoded redundant and synergistic information during auditory prediction error processing. In both tasks, we observed multiple patterns of synergy across the entire cortical hierarchy with distinct dynamics. The information conveyed by ERPs and BB signals was highly synergistic even at lower stages of the hierarchy in the auditory cortex, as well as between auditory and frontal regions. Using a brain-constrained neural network, we simulated the spatio-temporal patterns of synergy and redundancy observed in the experimental results and further demonstrated that the emergence of synergy between auditory and frontal regions requires the presence of strong, long-distance, feedback and feedforward connections. These results indicate that the distributed representations of prediction error signals across the cortical hierarchy can be highly synergistic.
Lévesque, C. André ; Brouwer, Henk ; Cano, Liliana ; Hamilton, John P. ; Holt, Carson ; Huitema, Edgar ; Raffaele, Sylvain ; Robideau, Gregg P. ; Thines, Marco ; Win, Joe ; Zerillo, Marcelo M. ; Beakes, Gordon W. ; Boore, Jeffrey L. ; Busam, Dana ; Dumas, Bernard ; Ferriera, Steve ; Fürstenberg, Susan ; Gachon, Claire M. M. ; Gaulin, Elodie ; Govers, Francine ; Grenville-Briggs, Laura ; Horner, Neil ; Hostetler, Jessica ; Jiang, Rays H. Y. ; Johnson, Justin ; Krajaejun, Theerapong ; Lin, Haining ; Meijer, Harold J. G. ; Moore, Barry ; Morris, Paul ; Phuntmart, Vipaporn ; Puiu, Daniela ; Shetty, Jyoti ; Stajich, Jason E. ; Tripathy, Sucheta ; Wawra, Stephan ; West, Pieter van ; Whitty, Brett R. ; Coutinho, Pedro M. ; Henrissat, Bernard ; Martin, Frank ; Thomas, Paul D. ; Tyler, Brett M. ; Vries, Ronald Peter de ; Kamoun, Sophien ; Yandell, Mark ; Tisserat, Ned ; Buell, C. Robin
Background: Pythium ultimum (P. ultimum) is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results: The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions although surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report in a genome outside the metazoans. Conclusions: Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bai, Xiaozhi ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Holub, Lukáš ; Horvat, S. ; Huang, X. ; Huang, B. ; Huang, Shengli ; Huang, H.Z. ; Huang, T. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, J. ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Kramárik, Lukáš ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Shyam ; Kumar, Lokesh ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, Xiaomei ; Li, C. ; Li, W. ; Li, Y. ; Liang, Y. ; Lidrych, J. ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, F. ; Liu, P. ; Liu, H. ; Liu, Y. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, X. ; Luo, S. ; Ma, G.L. ; Ma, Yu-Gang ; Ma, L. ; Ma, R. ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mayes, D. ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mondal, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Nasim, Md. ; Negrete, J.D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Oh, S. ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycień, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusňák, Jan ; Rusńáková, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shen, F. ; Shi, S.S. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, Y. ; Sun, X. ; Sun, X.M. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, G. ; Wang, Y. ; Wang, F. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, G. ; Xie, W. ; Xu, Q.H. ; Xu, Z. ; Xu, J. ; Xu, Y.F. ; Xu, N. ; Yang, S. ; Yang, C. ; Yang, Q. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, W. ; Zhang, Zuman ; Zhang, L. ; Zhang, Y. ; Zhang, X.P. ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, J. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, Z. ; Zhu, X. ; Zyzak, Maksym
We present a measurement of inclusive J /ψ production at mid-rapidity (|y| < 1) in p+p collisions at a center-of-mass energy of √s = 200 GeV with the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The differential production cross section for J /ψ as a function of transverse momentum (p T ) for 0 < p T < 14 GeV/c and the total cross section are reported and compared to calculations from the color evaporation model and the non-relativistic Quantum Chromodynamics model. The dependence of J /ψ relative yields in three p T intervals on charged-particle multiplicity at mid-rapidity is measured for the first time in p+p collisions at √s = 200 GeV and compared with that measured at √s = 7 TeV, PYTHIA8 and EPOS3 Monte Carlo generators, and the Percolation model prediction.
Bahls, Martin ; Lorenz, Matthias W. ; Dörr, Marcus ; Gao, Lu ; Kitagawa, Kazuo ; Tuomainen, Tomi-Pekka ; Agewall, Stefan ; Berenson, Gerald ; Catapano, Alberico L. ; Norata, Giuseppe D. ; Bots, Michiel L. ; Gilst, Wiek van ; Asselbergs, Folkert W. ; Brouwers, Frank P. ; Uthoff, Heiko ; Sander, Dirk ; Poppert, Holger ; Hecht Olsen, Michael ; Empana, Jean Philippe ; Schminke, Ulf ; Baldassarre, Damiano ; Veglia, Fabrizio ; Franco, Oscar H. ; Kavousi, Maryam ; Groot, Eric de ; Mathiesen, Ellisiv B. ; Grigore, Liliana ; Polak, Joseph F. ; Rundek, Tatjana ; Stehouwer, Coen D. A. ; Skilton, Michael R. ; Hatzitolios, Apostolos I. ; Savopoulos, Christos ; Ntaios, George ; Plichart, Matthieu ; McLachlan, Stela ; Lind, Lars ; Willeit, Peter ; Steinmetz, Helmuth ; Desvarieux, Moise ; Ikram, M. Arfan ; Johnsen, Stein Harald ; Schmidt, Caroline ; Willeit, Johann ; Ducimetiere, Pierre ; Price, Jackie F. ; Bergström, Göran ; Kauhanen, Jussi ; Kiechl, Stefan ; Sitzer, Matthias ; Bickel, Horst ; Sacco, Ralph L. ; Hofman, Albert ; Völzke, Henry ; Thompson, Simon G.
Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.
Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events.
Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.
Background The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the lack of typical cytological criteria in well differentiated specimens. New marker molecules, shown by poly- or monoclonal antibodies proved helpful. Methods We performed global gene expression analysis of 12 follicular thyroid tumours (4 follicular adenomas, 4 minimal invasive follicular carcinomas and 4 widely invasive follicular carcinomas), followed by immunohistochemical staining of 149 cases. The specificity of the antibody was validated by western blot analysis Results In gene expression analysis QPRT was detected as differently expressed between follicular thyroid adenoma and follicular thyroid carcinoma. QPRT protein could be detected by immunohistochemistry in 65% of follicular thyroid carcinomas including minimal invasive variant and only 22% of follicular adenomas. Conclusion Consequently, QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
Horst, Klemens ; Eschbach, Daphne-Asimenia ; Pfeifer, Roman ; Relja, Borna ; Sassen, Martin ; Steinfeldt, Thorsten ; Wulf, Hinnerk ; Vogt, Nina ; Frink, Michael ; Ruchholtz, Steffen ; Pape, Hans-Christoph ; Hildebrand, Frank
Background: Hypothermia has been discussed as playing a role in improving the early phase of systemic inflammation. However, information on the impact of hypothermia on the local inflammatory response is sparse. We therefore investigated the kinetics of local and systemic inflammation in the late posttraumatic phase after induction of hypothermia in an established porcine long-term model of combined trauma.
Materials & Methods: Male pigs (35 ± 5kg) were mechanically ventilated and monitored over the study period of 48 h. Combined trauma included tibia fracture, lung contusion, liver laceration and pressure-controlled hemorrhagic shock (MAP < 30 ± 5 mmHg for 90 min). After resuscitation, hypothermia (33°C) was induced for a period of 12 h (HT-T group) with subsequent re-warming over a period of 10 h. The NT-T group was kept normothermic. Systemic and local (fracture hematoma) cytokine levels (IL-6, -8, -10) and alarmins (HMGB1, HSP70) were measured via ELISA.
Results: Severe signs of shock as well as systemic and local increases of pro-inflammatory mediators were observed in both trauma groups. In general the local increase of pro- and anti-inflammatory mediator levels was significantly higher and prolonged compared to systemic concentrations. Induction of hypothermia resulted in a significantly prolonged elevation of both systemic and local HMGB1 levels at 48 h compared to the NT-T group. Correspondingly, local IL-6 levels demonstrated a significantly prolonged increase in the HT-T group at 48 h.
Conclusion: A prolonged inflammatory response might reduce the well-described protective effects on organ and immune function observed in the early phase after hypothermia induction. Furthermore, local immune response also seems to be affected. Future studies should aim to investigate the use of therapeutic hypothermia at different degrees and duration of application.
Demir, Münevver ; Lang, Sonja ; Martin, Anna ; Farowski, Fedja ; Wisplinghoff, Hilmar ; Vehreschild, Maria J. G. T. ; Krawczyk, Marcin ; Nowag, Angela ; Scholz, Claus Jürgen ; Kretzschmar, Anne ; Roderburg, Christoph ; Lammert, Frank ; Goeser, Tobias ; Kasper, Philipp ; Steffen, Hans‐Michael
Background and Aim: Several studies observed alterations in the gut microbiota in patients with non‐alcoholic fatty liver disease (NAFLD). However, analyzed patient populations and methods strongly differ among these studies. The aim of this study was to prove the reproducibility of published results and to provide a detailed overview of all findings in our NAFLD cohort using next generation sequencing methods.
Methods: The individual taxonomic microbiota composition of fecal samples from 90 NAFLD patients and 21 healthy controls was analyzed using 16S rRNA gene sequencing. Study participants were grouped according to their disease stage and compared regarding their gut microbiota composition. Studies were identified from PubMed listed publications, and the results were compared with the findings in our cohort.
Results: Results from 13 identified studies were compared with our data. A decreased abundance of the Bacteroidetes and Ruminococcaceae as well as an increased abundance of Lactobacillaceae and Veillonellaceae and Dorea were the most frequently reported changes among NAFLD patients in 4/13, 5/13, 4/13, 2/13, and 3/13 studies, respectively. Even though these alterations in the gut microbiota composition were also observed in our patient cohort, the majority of published differences could not be reproduced, neither in our own nor in other NAFLD cohort studies.
Conclusion: Despite repeatedly reproduced abundance patterns of specific bacteria, the heterogeneous study results did not reveal a consistent disease specific gut microbiota signature. Further prospective studies with homogenous patient cohorts and standardized methods are necessary to phenotype NAFLD by the gut microbiota.
Willems, Laurent Maximilian ; Bertsche, Astrid ; Bösebeck, Frank ; Hornemann, Frauke ; Immisch, Ilka ; Klein, Karl Martin ; Knake, Susanne ; Kunz, Rhina ; Kurlemann, Gerhard ; Langenbruch, Lisa Marie ; Möddel, Gabriel ; Müller-Schlüter, Karen ; Podewils, Felix von ; Reif, Philipp Sebastian ; Steinhoff, Bernhard J. ; Steinig, Isabel ; Rosenow, Felix ; Schubert-Bast, Susanne ; Strzelczyk, Adam
Objective: To evaluate the efficacy and tolerability of brivaracetam (BRV) in a severely drug refractory cohort of patients with epileptic encephalopathies (EE).
Method: A multicenter, retrospective cohort study recruiting all patients treated with EE who began treatment with BRV in an enrolling epilepsy center between 2016 and 2017.
Results: Forty-four patients (27 male [61%], mean age 29 years, range 6 to 62) were treated with BRV. The retention rate was 65% at 3 months, 52% at 6 months and 41% at 12 months. A mean retention time of 5 months resulted in a cumulative exposure to BRV of 310 months. Three patients were seizure free during the baseline. At 3 months, 20 (45%, 20/44 as per intention-to-treat analysis considering all patients that started BRV including three who were seizure free during baseline) were either seizure free (n = 4; 9%, three of them already seizure-free at baseline) or reported at least 25% (n = 4; 9%) or 50% (n = 12; 27%) reduction in seizures. An increase in seizure frequency was reported in two (5%) patients, while there was no change in the seizure frequency of the other patients. A 50% long-term responder rate was apparent in 19 patients (43%), with two (5%) free from seizures for more than six months and in nine patients (20%, with one [2 %] free from seizures) for more than 12 months. Treatment-emergent adverse events were predominantly of psychobehavioural nature and were observed in 16%.
Significance: In this retrospective analysis the rate of patients with a 50% seizure reduction under BRV proofed to be similar to those seen in regulatory trials for focal epilepsies. BRV appears to be safe and relatively well tolerated in EE and might be considered in patients with psychobehavioral adverse events while on levetiracetam.
Hiranuma, Naruki ; Augustin-Bauditz, Stefanie ; Bingemer, Heinz ; Budke, Carsten ; Curtius, Joachim ; Danielczok, Anja ; Diehl, Karoline ; Dreischmeier, Katharina ; Ebert, Martin ; Frank, Fabian ; Hoffmann, Nadine ; Kandler, Konrad ; Kiselev, Alexei ; Koop, Thomas ; Leisner, Thomas ; Möhler, Ottmar ; Nillius, Björn ; Peckhaus, Andreas ; Rose, Diana ; Weinbruch, Stephan ; Wex, Heike ; Boose, Yvonne ; DeMott, Paul J. ; Hader, John D. ; Hill, Thomas C. ; Kanji, Zamin A. ; Kulkarni, Gargi ; Levin, Ezra J. T. ; McCluskey, Christina S. ; Murakami, Masataka ; Murray, Benjamin J. ; Niedermeier, Dennis ; Petters, Markus D. ; O'Sullivan, Daniel ; Saito, Atsushi ; Schill, Gregory P. ; Tajiri, Takuya ; Tolbert, Margret A. ; Welti, André ; Whale, Thomas F. ; Wright, Timothy P. ; Yamashita, Katsuya
Immersion freezing is the most relevant heterogeneous ice nucleation mechanism through which ice crystals are formed in mixed-phase clouds. In recent years, an increasing number of laboratory experiments utilizing a variety of instruments have examined immersion freezing activity of atmospherically relevant ice nucleating particles (INPs). However, an inter-comparison of these laboratory results is a difficult task because investigators have used different ice nucleation (IN) measurement methods to produce these results. A remaining challenge is to explore the sensitivity and accuracy of these techniques and to understand how the IN results are potentially influenced or biased by experimental parameters associated with these techniques.
Within the framework of INUIT (Ice Nucleation research UnIT), we distributed an illite rich sample (illite NX) as a representative surrogate for atmospheric mineral dust particles to investigators to perform immersion freezing experiments using different IN measurement methods and to obtain IN data as a function of particle concentration, temperature (T), cooling rate and nucleation time. Seventeen measurement methods were involved in the data inter-comparison. Experiments with seven instruments started with the test sample pre-suspended in water before cooling, while ten other instruments employed water vapor condensation onto dry-dispersed particles followed by immersion freezing. The resulting comprehensive immersion freezing dataset was evaluated using the ice nucleation active surface-site density (ns) to develop a representative ns(T) spectrum that spans a wide temperature range (−37 °C < T < −11 °C) and covers nine orders of magnitude in ns.
Our inter-comparison results revealed a discrepancy between suspension and dry-dispersed particle measurements for this mineral dust. While the agreement was good below ~ −26 °C, the ice nucleation activity, expressed in ns, was smaller for the wet suspended samples and higher for the dry-dispersed aerosol samples between about −26 and −18 °C. Only instruments making measurement techniques with wet suspended samples were able to measure ice nucleation above −18 °C. A possible explanation for the deviation between −26 and −18 °C is discussed. In general, the seventeen immersion freezing measurement techniques deviate, within the range of about 7 °C in terms of temperature, by three orders of magnitude with respect to ns. In addition, we show evidence that the immersion freezing efficiency (i.e., ns) of illite NX particles is relatively independent on droplet size, particle mass in suspension, particle size and cooling rate during freezing. A strong temperature-dependence and weak time- and size-dependence of immersion freezing efficiency of illite-rich clay mineral particles enabled the ns parameterization solely as a function of temperature. We also characterized the ns (T) spectra, and identified a section with a steep slope between −20 and −27 °C, where a large fraction of active sites of our test dust may trigger immersion freezing. This slope was followed by a region with a gentler slope at temperatures below −27 °C. A multiple exponential distribution fit is expressed as ns(T) = exp(23.82 × exp(−exp(0.16 × (T + 17.49))) + 1.39) based on the specific surface area and ns(T) = exp(25.75 × exp(−exp(0.13 × (T + 17.17))) + 3.34) based on the geometric area (ns and T in m−2 and °C, respectively). These new fits, constrained by using an identical reference samples, will help to compare IN measurement methods that are not included in the present study and, thereby, IN data from future IN instruments.
Worringen, Annette ; Kandler, Konrad ; Benker, Nathalie ; Dirsch, Thomas ; Weinbruch, Stephan ; Mertes, Stephan ; Schenk, Ludwig ; Kästner, Udo ; Frank, Fabian ; Nillius, Björn ; Bundke, Ulrich ; Rose, Diana ; Curtius, Joachim ; Kupiszewski, Piotr ; Weingartner, Ernest ; Schneider, Johannes ; Schmidt, Susan ; Ebert, Martin
In the present work, three different techniques are used to separate ice-nucleating particles (INP) and ice particle residuals (IPR) from non-ice-active particles: the Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI), which sample ice particles from mixed phase clouds and allow for the analysis of the residuals, as well as the combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Virtual Impactor (IN-PCVI), which provides ice-activating conditions to aerosol particles and extracts the activated ones for analysis. The collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine their size, chemical composition and mixing state. Samples were taken during January/February 2013 at the High Alpine Research Station Jungfraujoch. All INP/IPR-separating techniques had considerable abundances (median 20–70%) of contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH + IN-PCVI: steel particles). Also, potential measurement artifacts (soluble material) occurred (median abundance < 20%). After removal of the contamination particles, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Minor types include soot and Pb-bearing particles. Sea-salt and sulfates were identified by all three methods as INP/IPR. Lead was identified in less than 10% of the INP/IPR. It was mainly present as an internal mixture with other particle types, but also external lead-rich particles were found. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also sampled many submicron particles. Probably owing to the different meteorological conditions, the INP/IPR composition was highly variable on a sample to sample basis. Thus, some part of the discrepancies between the different techniques may result from the (unavoidable) non-parallel sampling. The observed differences of the particles group abundances as well as the mixing state of INP/IPR point to the need of further studies to better understand the influence of the separating techniques on the INP/IPR chemical composition.
Kandler, Konrad ; Worringen, Annette ; Benker, Nathalie ; Dirsch, Thomas ; Mertes, Stephan ; Schenk, Ludwig ; Kästner, Udo ; Frank, Fabian ; Nillius, Björn ; Bundke, Ulrich ; Rose, Diana ; Curtius, Joachim ; Kupiszewski, Piotr ; Weingartner, Ernest ; Vochezer, Paul ; Schneider, Johannes ; Schmidt, Susan ; Weinbruch, Stephan ; Ebert, Martin
During January/February 2013, at the High Alpine Research Station Jungfraujoch a measurement campaign was carried out, which was centered on atmospheric ice-nucleating particles (INP) and ice particle residuals (IPR). Three different techniques for separation of INP and IPR from the non-ice-active particles are compared. The Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI) sample ice particles from mixed phase clouds and allow for the analysis of the residuals. The combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Counterflow Virtual Impactor (IN-PCVI) provides ice-activating conditions to aerosol particles and extracts the activated INP for analysis.Collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine size, chemical composition and mixing state. All INP/IPR-separating techniques had considerable abundances (median 20 – 70 %) of instrumental contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH+IN-PCVI: steel particles). Also, potential sampling artifacts (e.g., pure soluble material) occurred with a median abundance of < 20 %. While these could be explained as IPR by ice break-up, for INP their IN-ability pathway is less clear. After removal of the contamination artifacts, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Soot was a minor contributor. Lead was detected in less than 10 % of the particles, of which the majority were internal mixtures with other particle types. Sea-salt and sulfates were identified by all three methods as INP/IPR. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also separated many submicron IPR. As strictly parallel sampling could not be performed, a part of the discrepancies between the different techniques may result from variations in meteorological conditions and subsequent INP/IPR composition. The observed differences in the particle group abundances as well as in the mixing state of INP/IPR express the need for further studies to better understand the influence of the separating techniques on the INP/IPR chemical
composition.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bai, Xiaozhi ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chang, F.-H. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, Subhasis ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Holub, Lukáš ; Horvat, S. ; Huang, Bingchu ; Huang, X. ; Huang, Shengli ; Huang, T. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Kramárik, Lukáš ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Shyam ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, Y. ; Li, W. ; Li, C. ; Li, Xiaomei ; Liang, Y. ; Lidrych, J. ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, H. ; Liu, P. ; Liu, F. ; Liu, Y. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, S. ; Luo, X. ; Ma, L. ; Ma, G.L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mayes, D. ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Nasim, Md. ; Negrete, J.D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Oh, Kunsu ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shen, F. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X. ; Sun, Y. ; Sun, X.M. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, F. ; Wang, G. ; Wang, Y. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, W. ; Xie, Guannan ; Xu, Z. ; Xu, J. ; Xu, Y.F. ; Xu, N. ; Xu, Qinghua ; Yang, Y. ; Yang, C. ; Yang, S. ; Yang, Q. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Zuman ; Zhang, J. ; Zhang, L. ; Zhang, J. ; Zhang, Y. ; Zhang, X.P. ; Zhang, S. ; Zhang, S. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, Z. ; Zhu, X. ; Zyzak, Maksym
We present the first measurement of the proton–Ω correlation function in heavy-ion collisions for the central (0–40%) and peripheral (40–80%) Au + Au collisions at √sNN = 200 GeV by the STAR experiment at the Relativistic Heavy-Ion Collider (RHIC). Predictions for the ratio of peripheral collisions to central collisions for the proton–Ω correlation function are sensitive to the presence of a nucleon– bound state. These predictions are based on the proton– interaction extracted from (2 + 1)-flavor lattice QCD calculations at the physical point. The measured ratio of the proton–Ω correlation function between the peripheral (small system) and central (large system) collisions is less than unity for relative momentum smaller than 40 MeV/c. Comparison of our measured correlation ratio with theoretical calculation slightly favors a proton– bound system with a binding energy of ∼ 27 MeV.
Investigation of the linear and mode-coupled flow harmonics in Au+Au collisions at √sNN = 200 GeV
(2020)
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chen, D. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Cherney, Michael Gerard ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harabasz, Szymon ; Harris, John W. ; He, S. ; He, W. ; He, Xionghong ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Hu, Y. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kiselev, A. ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Yue Hang ; Li, C. ; Li, W. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lukow, N.S. ; Luo, S. ; Luo, X. ; Ma, G.L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pandav, Ashish ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, F. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y.F. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Yang, Z. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zurek, Marian ; Zyzak, Maksym
Flow harmonics (vn) of the Fourier expansion for the azimuthal distributions of hadrons are commonly employed to quantify the azimuthal anisotropy of particle production relative to the collision symmetry planes. While lower order Fourier coefficients (v2 and v3) are more directly related to the corresponding eccentricities of the initial state, the higher-order flow harmonics (vn>3) can be induced by a modecoupled response to the lower-order anisotropies, in addition to a linear response to the same-order anisotropies. These higher-order flow harmonics and their linear and mode-coupled contributions can be used to more precisely constrain the initial conditions and the transport properties of the medium in theoretical models. The multiparticle azimuthal cumulant method is used to measure the linear and mode-coupled contributions in the higher-order anisotropic flow, the mode-coupled response coefficients, and the correlations of the event plane angles for charged particles as functions of centrality and transverse momentum in Au+Au collisions at nucleon-nucleon center-of-mass energy √sN N= 200 GeV. The results are compared to similar LHC measurements as well as to several viscous hydrodynamic calculations with varying initial conditions.
Measurement of groomed jet substructure observables in p+p collisions at √s = 200 GeV with STAR
(2020)
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chen, D. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Cherney, Michael Gerard ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harabasz, Szymon ; Harris, John W. ; He, S. ; He, W. ; He, Xionghong ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Hu, Y. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kiselev, A. ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Yue Hang ; Li, C. ; Li, W. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lukow, N.S. ; Luo, S. ; Luo, X. ; Ma, G.L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pandav, Ashish ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, F. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y.F. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Yang, Z. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zurek, Marian ; Zyzak, Maksym
In this letter, measurements of the shared momentum fraction (zg) and the groomed jet radius (Rg), as defined in the SoftDrop algorithm, are reported in p+p collisions at √s = 200 GeV collected by the STAR experiment. These substructure observables are differentially measured for jets of varying resolution parameters from R = 0.2 − 0.6 in the transverse momentum range 15 < pT,jet < 60 GeV/c. These studies show that, in the pT,jet range accessible at √s = 200 GeV and with increasing jet resolution parameter and jet transverse momentum, the zg distribution asymptotically converges to the DGLAP splitting kernel for a quark radiating a gluon. The groomed jet radius measurements reflect a momentum-dependent narrowing of the jet structure for jets of a given resolution parameter, i.e., the larger the pT,jet, the narrower the first splitting. For the first time, these fully corrected measurements are compared to Monte Carlo generators with leading order QCD matrix elements and leading log in the parton shower, and to state-of-the-art theoretical calculations at next-to-leading-log accuracy. We observe that PYTHIA 6 with parameters tuned to reproduce RHIC measurements is able to quantitatively describe data, whereas PYTHIA 8 and HERWIG 7, tuned to reproduce LHC data, are unable to provide a simultaneous description of both zg and Rg, resulting in opportunities for fine parameter tuning of these models for p+p collisions at RHIC energies. We also find that the theoretical calculations without non-perturbative corrections are able to qualitatively describe the trend in data for jets of large resolution parameters at high pT,jet, but fail at small jet resolution parameters and low jet transverse momenta.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F.-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Crawford, Henry J. ; Csanád, Máté ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harris, John W. ; He, L. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Huang, Bingchu ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, C. ; Li, W. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, S. ; Luo, X. ; Ma, G.L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nasim, Md. ; Nayak, Kishora ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, F. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Wang, F. ; Wang, G. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y.F. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Yang, Z. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Dingwei ; Zhang, L. ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Zuman ; Zhao, Jie ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zurek, Marian ; Zyzak, Maksym
Quark interactions with topological gluon configurations can induce chirality imbalance and local parity violation in quantum chromodynamics. This can lead to electric charge separation along the strong magnetic field in relativistic heavy-ion collisions – the chiral magnetic effect (CME). We report measurements by the STAR collaboration of a CME-sensitive observable in p + Au and d + Au collisions at 200 GeV, where the CME is not expected, using charge-dependent pair correlations relative to a third particle. We observe strong charge-dependent correlations similar to those measured in heavy-ion collisions. This bears important implications for the interpretation of the heavy-ion data.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bueltmann, S. ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chen, D. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Cherney, Michael Gerard ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harabasz, Szymon ; Harris, John W. ; He, S. ; He, W. ; He, Xionghong ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Hu, Y. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kiselev, A. ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Yue Hang ; Li, C. ; Li, W. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lukow, N.S. ; Luo, S. ; Luo, X. ; Ma, G.L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pandav, Ashish ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Sheikh, Ashik Ikbal ; Shen, F. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y.F. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Yang, Z. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zurek, Marian ; Zyzak, Maksym
We report results on the total and elastic cross sections in proton-proton collisions at √s = 200 GeV obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section was measured in the squared four-momentum transfer range 0.045 ≤ −t ≤ 0.135 GeV2. The value of the exponential slope parameter B of the elastic differential cross section dσ/dt ∼ e−Bt in the measured −t range was found to be B = 14.32 ± 0.09(stat.)+0.13 −0.28(syst.) GeV−2. The total cross section σtot, obtained from extrapolation of the dσ/dt to the optical point at −t = 0, is σtot = 54.67 ± 0.21(stat.)+1.28 −1.38(syst.) mb. We also present the values of the elastic cross section σel = 10.85 ± 0.03(stat.)+0..49 −0.41(syst.) mb, the elastic cross section integrated within the STAR t-range σ det el = 4.05 ± 0.01(stat.)+0.18−0.17(syst.) mb, and the inelastic cross section σinel = 43.82 ± 0.21(stat.)+1.37−1.44(syst.) mb. The results are compared with the world data
Röhlen, Natascha ; Döring, Claudia ; Hansmann, Martin-Leo ; Grünwald, Frank ; Vorländer, Christian ; Bechstein, Wolf Otto ; Holzer, Katharina ; Badenhoop, Klaus ; Penna Martinez, Marissa
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.
Methods: The SNP's FOXO3a rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). Moreover, T-helper cells of HC and papillary thyroid cancer cell line BCPAP were incubated with 1,25(OH)2D3 and/or SIRT1 inhibitor Ex-527 in order to elucidate SIRT1- dependent vitamin D effects on cell proliferation and FOXO3a gene expression in vitro.
Results: Patients with DTC tended to carry more often allele C in FOXO3a rs4946936 in comparison to HC (pcorrected = pc = 0.08). FOXO3a rs9400239T and rs4945816C was more frequent in HT in comparison to HC (pc = 0.02 and pc = 0.01, respectively). In both DTC and HT, we could not find a correlation of FOXO3a SNP's with vitamin D status. However, on in vitro level, 1,25(OH)2D3 showed an anti-proliferative effect in both T-helper cells and BCPAP, that was blocked by SIRT1 inhibition (T-helper cells: p = 0.0059, BCPAP: p = 0.04) and accompanied by elevated FOXO3a gene expression in T-helper cells (p = 0.05).
Conclusions: FOXO3a rs9400239T and rs4945816C may constitute risk factors for HT, independent of the vitamin D status.This indicates the implication of FOXO3a in pathogenesis of autoimmune thyroid diseases. The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.
Abdulhamid, Muhammad Ibrahim ; Aboona, Bassam ; Adam, Jaroslav ; Adams, Joseph ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, Alisher ; Alekseev, Igor ; Anderson, Derek ; Aparin, Alexey ; Aslam, Sameer ; Atchison, Joseph ; Averichev, Georgy ; Bairathi, Vipul ; Baker, William ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bordyuzhin, Igor G. ; Brandenburg, James ; Brandin, Andrei ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel ; Češka, Jakub ; Chakaberia, Irakli ; Chan, Brian ; Chang, Zilong ; Chatterjee, Arghya ; Chen, Ding ; Chen, J. ; Chen, J.H. ; Chen, Zhenyu ; Cheng, Jianping ; Cheng, Yunshan ; Choudhury, Subikash ; Christie, Bill ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Dale-Gau, Gabriel ; Das, Ayanabha ; Daugherity, Michael ; Dedovich, Tatiana ; Deppner, Ingo Martin ; Derevschikov, Anatoly ; Dhamija, Arushi ; Di Carlo, Launa ; Dixit, Prabhupada ; Dong, Xin ; Drachenberg, James ; Duckworth, Emilie ; Dunlop, James ; Engelage, Jack ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga ; Ewigleben, Annika ; Eyser, Kjeld Oleg ; Fatemi, Renee ; Fazio, Salvatore ; Feng, Chan-Jui ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Flor, Fernando Antonio ; Fu, Chuan ; Gao, Taoya ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, Xingrui ; Grosnick, David P. ; Gupta, Anik ; Hamed, Ahmed ; Han, Yiding ; Harasty, Matthew D. ; Harris, John W. ; Harrison-Smith, Hannah ; He, Wanbing ; He, Xionghong ; He, Yang ; Hu, Chenlu ; Hu, Qiang ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, Te-Chuan ; Huang, Xinjie ; Huang, Y. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, Donald ; Isshiki, Moe ; Jacobs, William ; Jalotra, Ashish ; Jena, Chitrasen ; Ji, Yuanjing ; Jia, Jiangyong ; Jin, Chenliang ; Ju, Xin-Yue ; Judd, Eleanor ; Kabana, Sonia ; Kabir, Md Latiful ; Kalinkin, Dmitry ; Kang, Kejun ; Kapukchyan, David ; Kauder, Kolja ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Kimelman, Benjamin ; Kiselev, Alexander ; Knospe, Anders ; Ko, Ho San ; Kochenda, Leonid ; Korobitsin, Artem ; Kravtsov, Petr ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Lacey, Roy Alphanso ; Landgraf, Jeffery ; Lebedev, Alexei ; Lednicky, Richard ; Lee, Jeong-Hun ; Leung, Yue Hang ; Lewis, Nicole ; Li, Changfeng ; Li, Wei ; Li, Xiujun ; Li, Y. ; Li, Y. ; Li, Ziyang ; Liang, Xilin ; Liang, Yue ; Lin, Ting ; Liu, Chengyang ; Liu, Feng ; Liu, Guoming ; Liu, H. ; Liu, H. ; Liu, Li-ke ; Liu, Tong ; Liu, Xiaoyu ; Liu, Yanfang ; Liu, Zuowen ; Ljubicic, Tonko ; Llope, William Joseph ; Lomicky, Ondrej ; Longacre, Ronald S. ; Loyd, E.M. ; Lu, Tan ; Lukow, Nicholas ; Luo, Xiaofeng ; Luong, V.B. ; Ma, Long ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spiros ; Matis, Howard ; Mazer, Joel Anthony ; McNamara, Grant ; Mi, K. ; Minaev, Nikolai ; Mohanty, Bedanga ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry ; Mudrokh, Aleksandr ; Nagy, Marton ; Nain, Ankita ; Nam, J.D. ; Nasim, M. ; Neff, Dylan ; Nelson, John M. ; Nemes, Daniel ; Nie, Maowu ; Nigmatkulov, Grigory ; Niida, Takafumi ; Nishitani, Risa ; Nogach, Larisa ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Okubo, Kosuke ; Page, Brian ; Pak, Robert ; Pan, Jinjin ; Pandav, Ashish ; Pandey, Ashutosh ; Panebratsev, Yuri ; Pani, Tanmay ; Parfenov, Petr ; Paul, Ananya ; Perkins, Chris ; Pokhrel, B.R. ; Posik, Matthew ; Protzman, Tristan ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Qin, Zhi ; Qiu, Hao ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, Nandita ; Ray, Lanny ; Ritter, Hans Georg ; Robertson, Charles ; Rogachevskiy, Oleg ; Rosales Aguilar, Manuel ; Roy, Diptanil ; Ruan, Lijuan ; Sahoo, Aswini ; Sahoo, Nihar Ranjan ; Sako, Hiroyuki ; Salur, Sevil ; Samigullin, Edward ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Seger, Janet ; Seto, Richard ; Seyboth, Peter ; Shah, Neha ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, Tianhao ; Sharma, Mahima ; Sharma, Natasha ; Sharma, Rishabh ; Sharma, Sharang Rav ; Sheikh, Ashik Ikbal ; Shen, D. ; Shen, D.Y. ; Shen, Kaifeng ; Shi, Shusu ; Shi, Yingying ; Shou, Qiye ; Si, Fan ; Singh, Jagbir ; Singha, Subhash ; Sinha, Priyanshi ; Skoby, Michael J. ; Soehngen, Yannick ; Song, Youqi ; Srivastava, Brijesh ; Stanislaus, Shirvel ; Stewart, David ; Strikhanov, Mikhail ; Stringfellow, Blair ; Su, Yuan ; Sun, Chuan ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry ; Sweger, Zachary W. ; Tamis, Andrew ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terry ; Thomas, James H. ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Michael ; Tomkiel, Catherine ; Trentalange, Steven ; Tribble, Robert ; Tribedy, Prithwish ; Tsai, Oleg D. ; Tsang, Chun Yuen ; Tu, Zhoudunming ; Tyler, Jace ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vasiliev, Alexander ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, Fuqiang ; Wang, Gang ; Wang, J.S. ; Wang, J. ; Wang, Xiaofeng ; Wang, Y. ; Wang, Y. ; Wang, Y. ; Wang, Zhen ; Webb, Jason ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wieman, Howard ; Wilks, Gavin ; Wissink, Scott ; Wu, J. ; Wu, J. ; Wu, Xiao ; Wu, Xiao ; Wu, Yang ; Xi, Baoshan ; Xiao, Zhigang ; Xie, Guannan ; Xie, Wei ; Xu, Haojie ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, Gaoguo ; Yan, Zhengxi ; Yang, Chi ; Yang, Qian ; Yang, Shuai ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, Kin ; Yu, Y. ; Zha, Wangmei ; Zhang, ChunJian ; Zhang, Dingwei ; Zhang, Jinlong ; Zhang, Shenghui ; Zhang, Wei ; Zhang, Xin ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Z. ; Zhang, Z. ; Zhao, Fengyi ; Zhao, Jie ; Zhao, Minghui ; Zhou, Chensheng ; Zhou, Jian ; Zhou, Shuai ; Zhou, Yingjie ; Zhu, Xianglei ; Żurek, Maria Katarzyna ; Zyzak, Maksym
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
Queck, Alexander David Roger ; Uschner, Frank Erhard ; Ferstl, Philip ; Schulz, Martin ; Brol, Maximilian ; Praktiknjo, Michael ; Schierwagen, Robert ; Klein, Sabine ; Straßburg, Christian P. ; Meyer, Carsten ; Jansen, Christian ; Berres, Marie-Luise ; Trebicka, Jonel
Background: Pathogenesis of portal hypertension is multifactorial and includes pathologic intrahepatic angiogenesis, whereby TIPS insertion is an effective therapy of portal hypertension associated complications. While angiogenin is a potent contributor to angiogenesis in general, little is known about its impact on TIPS function over time. Methods: In a total of 118 samples from 47 patients, angiogenin concentrations were measured in portal and inferior caval vein plasma at TIPS insertion (each blood compartment n = 23) or angiographic intervention after TIPS (each blood compartment n = 36) and its relationship with patient outcome was investigated. Results: Angiogenin levels in the inferior caval vein were significantly higher compared to the portal vein (P = 0.048). Ten to 14 days after TIPS, inferior caval vein angiogenin level correlated inversely with the portal systemic pressure gradient (P<0.001), measured invasively during control angiography. Moreover, patients with TIPS revision during this angiography, showed significantly lower angiogenin level in the inferior caval vein compared to patients without TIPS dysfunction (P = 0.01). Conclusion: In cirrhosis patients with complications of severe portal hypertension, circulating levels of angiogenin are derived from the injured liver. Moreover, angiogenin levels in the inferior caval vein after TIPS may predict TIPS dysfunction.