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By analyzing e+e− annihilation data corresponding to an integrated luminosity of 2.93fb−1 collected at the center-of-mass energy of 3.773\,GeV with the BESIII detector, we report the first observations of the doubly Cabibbo-suppressed decays D+→K+π0π0 and D+→K+π0η. The branching fractions of D+→K+π0π0 and D+→K+π0η are measured to be (2.1±0.4stat±0.1syst)×10−4 and (2.1±0.5stat±0.1syst)×10−4 with statistical significances of 8.8σ and 5.5σ, respectively. In addition, we search for the subprocesses D+→K∗(892)+π0 and D+→K∗(892)+η with K∗(892)+→K+π0. The branching fraction of D+→K∗(892)+η is determined to be (4.4+1.8−1.5stat±0.2syst)×10−4, with a statistical significance of 3.2σ. No significant signal for D+→K∗(892)+π0 is found and we set an upper limit on the branching fraction of this decay at the 90\% confidence level to be 5.4×10−4.
By analyzing e+e− annihilation data corresponding to an integrated luminosity of 2.93fb−1 collected at the center-of-mass energy of 3.773\,GeV with the BESIII detector, we report the first observations of the doubly Cabibbo-suppressed decays D+→K+π0π0 and D+→K+π0η. The branching fractions of D+→K+π0π0 and D+→K+π0η are measured to be (2.1±0.4stat±0.1syst)×10−4 and (2.1±0.6stat±0.1syst)×10−4 with statistical significances of 8.0σ and 5.0σ, respectively. In addition, we search for the subprocesses D+→K∗(892)+π0 and D+→K∗(892)+η with K∗(892)+→K+π0. The branching fraction of D+→K∗(892)+η is determined to be (4.7+1.9−1.6stat±0.2syst)×10−4, with a statistical significance of 3.3σ. No significant signal for D+→K∗(892)+π0 is found and we set an upper limit on the branching fraction of this decay at the 90\% confidence level to be 4.5×10−4.
Ten hadronic final states of the ℎ𝑐 decays are investigated via the process 𝜓(3686)→𝜋0ℎ𝑐, using a data sample of (448.1±2.9)×106 𝜓(3686) events collected with the BESIII detector. The decay channel ℎ𝑐→𝐾+𝐾−𝜋+𝜋−𝜋0 is observed for the first time and has a measured significance of 6.0𝜎. The corresponding branching fraction is determined to be ℬ(ℎ𝑐→𝐾+𝐾−𝜋+𝜋−𝜋0)=(3.3±0.6±0.6)×10−3 (where the uncertainties are statistical and systematic, respectively). Evidence for the decays ℎ𝑐→𝜋+𝜋−𝜋0𝜂 and ℎ𝑐→𝐾0𝑆𝐾±𝜋∓𝜋+𝜋− is found with a significance of 3.6𝜎 and 3.8𝜎, respectively. The corresponding branching fractions (and upper limits) are obtained to be ℬ(ℎ𝑐→𝜋+𝜋−𝜋0𝜂)=(7.2±1.8±1.3)×10−3 (<1.8×10−2) and ℬ(ℎ𝑐→𝐾0𝑆𝐾±𝜋∓𝜋+𝜋−)=(2.8±0.9±0.5)×10−3 (<4.7×10−3). Upper limits on the branching fractions for the final states ℎ𝑐→𝐾+𝐾−𝜋0, 𝐾+𝐾−𝜂, 𝐾+𝐾−𝜋+𝜋−𝜂, 2(𝐾+𝐾−)𝜋0, 𝐾+𝐾−𝜋0𝜂, 𝐾0𝑆𝐾±𝜋∓, and 𝑝¯𝑝𝜋0𝜋0 are determined at a confidence level of 90%.
Using a dedicated data sample taken in 2018 on the J/ψ peak, we perform a detailed study of the trigger efficiencies of the BESIII detector. The efficiencies are determined from three representative physics processes, namely Bhabha scattering, dimuon production and generic hadronic events with charged particles. The combined efficiency of all active triggers approaches 100% in most cases, with uncertainties small enough not to affect most physics analyses.
By analyzing e+e− annihilation data corresponding to an integrated luminosity of 2.93fb−1 collected at the center-of-mass energy of 3.773\,GeV with the BESIII detector, we report the first observations of the doubly Cabibbo-suppressed decays D+→K+π0π0 and D+→K+π0η. The branching fractions of D+→K+π0π0 and D+→K+π0η are measured to be (2.1±0.4stat±0.1syst)×10−4 and (2.1±0.5stat±0.1syst)×10−4 with statistical significances of 8.8σ and 5.5σ, respectively. In addition, we search for the subprocesses D+→K∗(892)+π0 and D+→K∗(892)+η with K∗(892)+→K+π0. The branching fraction of D+→K∗(892)+η is determined to be (4.4+1.8−1.5stat±0.2syst)×10−4, with a statistical significance of 3.2σ. No significant signal for D+→K∗(892)+π0 is found and we set an upper limit on the branching fraction of this decay at the 90\% confidence level to be 5.4×10−4.
Using a data sample of 4.481×108 𝜓(3686) events collected with the BESIII detector, we report the first observation of the four-lepton-decays 𝐽/𝜓→𝑒+𝑒−𝑒+𝑒− and 𝐽/𝜓→𝑒+𝑒−𝜇+𝜇− utilizing the process 𝜓(3686)→𝜋+𝜋−𝐽/𝜓. The branching fractions are determined to be [5.48±0.31(stat)±0.45(syst)]×10−5 and [3.53±0.22(stat)±0.13(syst)]×10−5, respectively. The results are consistent with theoretical predictions. No significant signal is observed for 𝐽/𝜓→𝜇+𝜇−𝜇+𝜇−, and an upper limit on the branching fraction is set at 1.6×10−6 at the 90% confidence level. A 𝐶𝑃 asymmetry observable is constructed for the first two channels, which is measured to be (−0.012±0.054±0.010) and (0.062±0.059±0.006), respectively. No evidence for 𝐶𝑃 violation is observed in this process.
Relative fractions and phases of the intermediate decays are determined. With the detection efficiency estimated by the results of the amplitude analysis, the branching fraction of Dþ s → K−Kþπþπ0 decay is measured to be ð5.42 0.10stat 0.17systÞ%.
Using 448.1 × 106 ψ(3686) decays collected with the BESIII detector at the BEPCII e+e− storage rings, the branching fractions and angular distributions of the decays χcJ → Ξ−Ξ¯¯¯¯+ and Ξ0Ξ¯¯¯¯0 (J = 0, 1, 2) are measured based on a partial-reconstruction technique. The decays χc1 → Ξ0Ξ¯¯¯¯0 and χc2 → Ξ0Ξ¯¯¯¯0 are observed for the first time with statistical significances of 7σ and 15σ, respectively. The results of this analysis are in good agreement with previous measurements and have significantly improved precision.
We report a search for a dark photon using 14.9~fb−1 of e+e− annihilation data taken at center-of-mass energies from 4.13 to 4.60~GeV with the BESIII detector operated at the BEPCII storage ring. The dark photon is assumed to be produced in the radiative annihilation process of e+e− and to predominantly decay into light dark matter particles, which escape from the detector undetected. The mass range from 1.5 to 2.9~GeV is scanned for the dark photon candidate, and no significant signal is observed. The mass dependent upper limits at the 90% confidence level on the coupling strength parameter ϵ for a dark photon coupling with an ordinary photon vary between 1.6×10−3 and 5.7×10−3.
Using 10.1 × 109 J/ψ events produced by the Beijing Electron Positron Collider (BEPCII) at a center-of-mass energy √s = 3.097 GeV and collected with the BESIII detector, we present a search for the rare semi-leptonic decay J/ψ → D−e+νe + c.c. No excess of signal above background is observed, and an upper limit on the branching fraction ℬ(J/ψ → D−e+νe + c. c.) < 7.1 × 10−8 is obtained at 90% confidence level. This is an improvement of more than two orders of magnitude over the previous best limit.
The electromagnetic process is studied with the initial-state-radiation technique using 7.5 fb−1 of data collected by the BESIII experiment at seven energy points from 3.773 to 4.600 GeV. The Born cross section and the effective form factor of the proton are measured from the production threshold to 3.0 GeV/ using the invariant-mass spectrum. The ratio of electric and magnetic form factors of the proton is determined from the analysis of the proton-helicity angular distribution.
Using e+e− collision data at ten center-of-mass energies between 2.644 and 3.080 GeV collected with the BESIII detector at BEPCII and corresponding to an integrated luminosity of about 500 pb−1, we measure the cross sections and effective form factors for the process e+e−→Ξ0Ξ¯0 utilizing a single-tag method. A fit to the cross section of e+e−→Ξ0Ξ¯0 with a pQCD-driven power function is performed, from which no significant resonance or threshold enhancement is observed. In addition, the ratio of cross sections for the processes e+e−→Ξ−Ξ¯+ and Ξ0Ξ¯0 is calculated using recent BESIII measurement and is found to be compatible with expectation from isospin symmetry.
Importance Surgery is a mainstay in the management of hidradenitis suppurativa (HS). Adalimumab is the first drug approved for HS. Objective To investigate the efficacy and safety of adalimumab in combination with wide-excision surgery followed by secondary intention healing. Design, Setting, and Participants The Safety and Efficacy of Adalimumab for Hidradenitis Suppurativa Peri-Surgically (SHARPS) trial was a phase 4, randomized, double-blind, placebo-controlled study of adalimumab in conjunction with surgery. Patients were enrolled in 45 sites across 20 countries from July 18, 2016, to February 2, 2019, with the last patient visit on October 16, 2019. Eligible patients (aged 18-65 years) had moderate to severe HS that required radical surgery in an axillary or inguinal region and had 2 other anatomical regions affected, with 1 or more regions at Hurley stage II or III. Analysis was conducted in November 2019. Interventions Patients were randomized 1:1 to receive continuous adalimumab, 40 mg, or placebo during presurgery (12 weeks), perioperative (2 weeks), and postoperative (10 weeks) periods. Main Outcomes and Measures The primary end point was the proportion of patients achieving HS clinical response across all body regions at week 12. Results Overall, 103 patients were randomized to adalimumab and 103 to matching placebo. Among all patients, 51% (n = 106) were women, 94% (n = 193) were White, and the mean (SD) age was 37.6 (11.3) years. At week 12, significantly more patients receiving adalimumab (49 of 103 [48%]) vs placebo (35 of 103 [34%]; P = .049) achieved HS clinical response across all body regions (treatment difference, 14% [95% CI, 0%-27%]). Treatment-emergent adverse events were reported in 74 of 103 patients (72%) and 69 of 103 patients (67%) in the adalimumab and placebo groups, respectively. No increased risk of postoperative wound infection, complication, or hemorrhage was observed with adalimumab vs placebo. Two deaths occurred in the adalimumab group; neither was considered as having a reasonable possibility of relationship to study drug. Conclusions and Relevance Adalimumab was efficacious in conjunction with wide-excision surgery followed by secondary intention healing, with no need to interrupt treatment prior to surgery. These data support further investigation of adalimumab as an adjuvant therapy to surgery in patients with moderate to severe HS. Trial Registration ClinicalTrials.gov Identifier: NCT02808975