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Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci, and prioritized 22 likely causal SNPs for BD. We mapped these SNPs to genes, and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci, and results from rare variant exome sequencing in BD. Convergent lines of evidence supported the roles of SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, PLCB3, PRDX5, KCNK4, AP001453.3, TRPT1, FKBP2, DNAJC4, RASGRP1, FURIN, FES, YWHAE, DPH1, GSDMB, MED24, THRA, EEF1A2, and KCNQ2 in BD. These represent promising candidates for functional experiments to understand biological mechanisms and therapeutic potential. Additionally, we demonstrated that fine-mapping effect sizes can improve performance and transferability of BD polygenic risk scores across ancestrally diverse populations, and present a high-throughput fine-mapping pipeline (https://github.com/mkoromina/SAFFARI).
The Bethylidae are a primitive family of aculeate Hymenoptera which presently consists of about 2,200 nominal species. They are worldwide in distribution and all species are primary, external parasites of Lepidoptera and Coleoptera larvae. Due t o their host associations, bethylids are potentially useful for the biological control of various agricultural pests in the aforementioned groups. Unfortunately, the true potential of bethylids in applied biological control cannot be ascertained now because they have been used infrequently. Some species show strong promise, but t h e i r use is handicapped by a relative lack of basic taxonomic and biological knowledge. The most recent world catalog for bethylids is Kieffer (1914). A world catalog is forthcoming (Gordh, in prep.). There has never been a compilation of the world literature.
Experiment NA49 at the Cern SPS uses a large acceptance detector for a systematic study of particle yields and correlations in nucleus-nucleus, nucleon-nucleus and nucleon-nucleon collisions. Preliminary results for Pb+Pb collisions at 40, 80 and 158 A*GeV beam energy are shown and compared to measurements at lower and higher energies.
Hereditary angioedema (HAE) is a disease which is associated with random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased Health Related Quality of Life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada is neither optimal nor uniform across the country. It lags behind other countries where there are more organized models for HAE management, and where additional therapeutic options are licensed and available for use. The objective of this guideline is to provide graded recommendations for the management of patients in Canada with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. It is anticipated that by providing this guideline to caregivers, policy makers, patients and their advocates, that there will be an improved understanding of the current recommendations regarding management of HAE and the factors that need to be considered when choosing therapies and treatment plans for individual patients. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency physicians, gastroenterologists, dentists and otolaryngologists, who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.
Dilatitibialis Duverger (61 species) (Coleoptera: Coccinelidae: Coccidulinae; Hyperaspidini) is discussed, species described, illustrations provided, and a key to all recognized taxa included. Cleothera cognata Mulsant, Cleothera cruciferae Mulsant, Cleothera fuscomaculata Mulsant, Cleothera gaynoni Mulsant, Cleothera glyphica Mulsant, Cleothera jucunda Mulsant, Cleothera luteola Mulsant, Cleothera mulsanti Kirsch, Cleothera oseryi Mulsant, Cleothera poortmanni Mulsant, Cleothera scenica Mulsant, Cleothera semicincta Weise, Cleothera tropicalis Mulsant, Hinda guttipennis Weise, Hyperaspis carolinae Crotch, Hyperaspis ceciliae Crotch, Hyperaspis dilatata Crotch, Hyperaspis florifera Vogel, Hyperaspis gravabilis Brèthes, Hyperaspis hybridula Crotch, Hyperaspis laterinotata Brèthes, Hyperaspis silvani Crotch, and Hyperaspis suzannae Crotch are transferred to Dilatitibialis, becoming new combinations. Lectotypes are designated for D. boliviana, D. cognata, D. florifera, D. fuscomaculata, D. gaynoni, D. glyphica, D. gravabilis, D. guttipennis, D. luteola, D. jucunda, D. mulsanti. D. poortmanni, D. retigera, D. scenica, D. semicincta, and D. staudingeri. A total of 38 new species of Dilatitibialis are described: Dilatitibialis annie, D. carmen, D. cindy, D. connie, D. crystal, D. dawn, D. diana, D. edith, D. edna, D. elaine, D. ellen, D. emily, D. ethel, D. fallax, D. florence, D. gladys, D. grace, D. josephine, D. kim, D. lillian, D. lois, D. marjorie, D. norma, D. paula, D. peggy, D. phyllis, D. rita, D. robin, D. rosa, D. shannon, D. sheila, D. sherry, D. sylvia, D. thelma, D. tiffany, D. tina, D. tracy, and D. wendy. Corrections are made to titles of previous Parts of this series, as follows: South American Coccinellidae, Part XII (Gordon 2007) is changed to Part XIII; South American Coccinellidae, Part XII (Gordon et al. 2013) is changed to Part XIV.
Cyrea Gordon and Canepari (121 species) and Tiphysa Mulsant (2 species) are discussed, species are described, illustrations are provided, and a key to all recognized species is included. New synonyms recognized are:
Hyperaspis arrowi var. darwini Brèthes = Cyrea arrowi (Brèthes); Hyperaspis trivittata Weise, Hyperaspis mundula Weise = Cyrea emiliae (Mulsant); Cleothera scapulata Mulsant, Cleothera mercabilis Mulsant, Hyperaspis iheringi Weise = Cyrea flavoguttata (Mulsant); Cleothera gracilis Mulsant = Cyrea hexastigma (Mulsant); Cleothera triacantha Mulsant = Cyrea novemsignata (Herbst); Cleothera distinguenda Mulsant = Cyrea ormanceayi (Mulsant); Cleothera sexnotata Brèthes = Cyrea quinquenotata (Mulsant); Cleothera schaufussi Vogel and Hyperaspis adelaida Gorham = Cyrea tessulata (Mulsant). A total of 76 new species of Cyrea are described: Cyrea agnes, C. allison, C.alma, C. annette, C. arlene, C. audrey, C. beatrice, C. bernice, C. bessie, C. brittany, C. carla, C. charlene, C. claudia, C. colleen, C. constance, C. courtney, C. dana, C. dolores, C. dora, C. eileen, C. ella, elsie, erica, georgia, gertrude, gina, glenda, heidi, holly, ida, jackie, jeanne, jeannette, jessie, jo, C. joy, C. june, C. katie, C. kristen, C. laurie, C. lillie, C. lucille, C. lucy, C. lydia, C. marcia, C. marian, C. marion, C. marlene, C. mattie, C. maureen, C. maxine, C. melanie, C. melinda, C. minnie, C. natalia, C. nellie, C. pearl, C. pseudospinalis, C. renee, C. roberta, C. rosemary, C. samantha, C. stacy, C. stella, C. sue, C. tamara, C. tanya, C. tara, C. terry, C. vanessa, C. vera, C. vicki, C. viola, C. vivian, C. willie, C. wilma, C. yolanda, C.
yvonne. Lectotypes here designated for C. collaris, C. compta, C. distinguenda, C. exclamationis, C. fasciata, C. ferruginiceps, C. flavoguttata, C. iheringi, C. languida, C. maculosa, C. melaneura, C. mundula, C. noticollis, C. novemsignata, C. ormanceayi, C. ornaticolis, C. quinquenotata, C. renifera, C. schaufussi, C. sexguttata, C. spinalis, C. tessulata, C. trepida, C. triacantha
Genera of Brachiacanthini (Coleoptera: Coccinellidae: Hyperaspidinae) are discussed and a key to all recognized genera provided. Cyrea, new genus, is proposed, and Serratitibia, new genus, is erected and revised, Cleothera Mulsant and Hinda Mulsant are recognized as valid genera and revised. Helesius caseyi Sicard is transferred to Hinda and recognized as a synonym of Hinda designata Mulsant, new synonymy. Brachiacantha brethesi (Korschefsky), Cleothera abendrothi Kirsch, Cleothera ambigua Mulsant, Cleothera bisquatuorpustulata Mulsant, Cleothera decemsignata Mulsant, Cleothera gaillardi Mulsant, Cleothera humerata Mulsant, Cleothera tortuosa Mulsant, Cleothera traili Brèthes, Cleothera uncinata Mulsant, Hinda joeli Almeida and Milléo, Hinda modesta Weise, Hinda regularis Kirsch, Hyperaspis aliciae Crotch, and Hyperaspis fraudulenta Kirsch are transferred to Serratitibia, becoming new combinations. One new species of Hinda, H. ecuadorica, is described. A total of 73 new species of Serratitibia are described: Serratitibia amanda, S. andrea, S. angela, S. anna, S. ashley, S. barbara, S. barclayi, S. betty, S. beverly, S. bonnie, S. brenda, S. cheryl, S. christine, S. cynthia, S. debra, S. denise, S. donna, S. doris, S. elizabeth, S. evelyn, S. frances, S. gloria, S. heather, S. helen, S. irene, S. jacqueline, S. janet, S. janice, S. jean, S. jennifer, S. joan, S. joyce, S. judith, S. judy, S. julie, S. karen, S. katherine, S. kathleen, S. kathy, S. kelly, S. kimberly, S. laura, S. linda, S. lisa, S. loreto, S. lori, S. louise, S. margaret, S. marilyn, S. mary, S. martha, S. melissa, S. michelle, S. mildred, S. nancy, S. nicole, S. pamela, S. paprzycki, S. patricia, S. quincemil, S. rachel, S. rebecca, S. rose, S. ruby, S. ruth, S. sarah, S. satipoensis, S. shirley, S. stephanie, S. susan, S. tammy, S. teresa, and S. virginia. Lectotypes are here designated for Serratitibia lividipes, S. gaillardi, S. decemsignata, S. abendrothi, and S. ambigua.
Genera of Cephaloscymnini (Coleoptera: Coccinellidae: Coccidulinae) are discussed and a key to all recognized genera and species is provided. Succinctonotum, new genus, is proposed. Scymnus laboulbenii Mulsant and Prodilis maculata Weise are transferred to Neaporia as new combinations. Prodiloides bipunctata Weise, and Neaporia compta are transferred to Prodilis as new combinations. Neaporia cuprea Gorham is considered a junior synonym of Neaporia viridiscens Gorham and Cephaloscymnus bruchi Weise a junior synonym of Prodilis volgus Mulsant. New species described in Cephaloscymnus are C. beulah, C. candice, C. juanita. New species described in Neaporia are N. becky, N. bobbie, N. brandy, N. carole, N. cassandra, N. christy, N. daisy, N. deanna, N. dianne, N. felicia, N. gwendolyn, N. hilda, N. irma, N. jennie, N. jenny, N. kay, N. kayla, N. kristine, N. leah, N. lena, N. leona, N. longifrons, N. mabel, N. mae, N. margie, N. marsha, N. miriam, N. misty, N. myrtle, N. naomi, N. nina, N. nora, N. olga, N. opal, N. patsy, N. penny, N. priscilla, N. shelley, N. sonia, N. tracey, and N. violet. New species described in Succinctonotum is S. frosti. New species described in Prodilis are P. ada, P. alberta, P. alison, P. amelia, P. angie, P. araguaensis, P. bartletti, P. belinda, P. blanche, P. brandi, P. cecilia, P. claire, P. cora, P. dubitalis, P. erika, P. eunice, P. fannie, P. faye, P. flora, P. geneva, P. guadalupe, P. harriet, P. hattie, P. inez, P. iris, P. isabel, P. jan, P. janie, P. joanna, P. jodi, P. katrina, P. kristi, P. kristy, P. lindsey, P. lola, P. lula, P. lynda, P. madeline, P. maggie, P. mamie, P. margarita, P. maryann, P. melody, P. molly, P. monique, P. natasha, P. olivia, P. pecki, P. ramona, P. rosie, P. sabrina, P. sandy, P. shelley, P. sherri, P. sheryl, P. sonya, P. susie, and P. yvette. Ponaria, new genus of Coccidulini is proposed. Neaporia caerulea Gorham is transferred to Ponaria as a new combination. New species described in Ponaria are P. daviesi, P. hurtadoi, and P. paprzyckii. Lectotypes are here designated for Neaporia arrowi, N. coelestis, N. metallica, N. guatemalana, N. indagator, and Prodilis pallidifrons.
Brachiacantha Dejean (Coccinellinae: Hyperaspidini), containing 49 species, is discussed, species described, illustrations provided, and a key to all recognized taxa included. Coccinella octopustulata F., Cleothera groendali Mulsant, Hyperaspis argentinica Weise, Hyperaspis blandula Weise, and Hyperaspis egae Crotch are transferred to Brachiacantha. Cleothera billoti parva Mulsant is recognized as a valid species and transferred to Brachiacantha. Brachiacantha arrowi Brèthes, Brachiacantha australe Leng, Brachiacantha manni Nunenmacher, and Brachiacantha propria Kirsch are recognized as synonyms of Brachiacantha groendali (Mulsant). A total of 29 new species of Brachiacantha are described; B. amber, B. anita, B. april, B. cathy, B. clara, B. charlotte, B. danielle, B. darlene, B. debbie, B. eleanor, B. emma, B. esther, B. eva, B. gail, B. hazel, B. jamie, B. joanne, B. jill, B. juanita, B. lauren, B. leslie, B. lynn, B. monica, B. pauline, B. pseudoarrowi, B. regina, B. sally, B. valerie, and B. veronica. Lectotypes are designated for B. argentinica (Weise), B. armandi (Mulsant), B. arrowi Brèthes, B. bahiensis Brethès, B. bilineata Weise, B. blandula Weise, B. bruchi Weise, B. loricata (Mulsant), B. octopustulata (F.), B. propria Kirsch.
Short-term memory requires the coordination of sub-processes like encoding, retention, retrieval and comparison of stored material to subsequent input. Neuronal oscillations have an inherent time structure, can effectively coordinate synaptic integration of large neuron populations and could therefore organize and integrate distributed sub-processes in time and space. We observed field potential oscillations (14–95 Hz) in ventral prefrontal cortex of monkeys performing a visual memory task. Stimulus-selective and performance-dependent oscillations occurred simultaneously at 65–95 Hz and 14–50 Hz, the latter being phase-locked throughout memory maintenance. We propose that prefrontal oscillatory activity may be instrumental for the dynamical integration of local and global neuronal processes underlying short-term memory.