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Language
- English (8)
Has Fulltext
- yes (8)
Is part of the Bibliography
- no (8)
Keywords
- CVID (1)
- European Society for Immunodeficiencies (ESID) (1)
- German PID-NET registry (1)
- IgG substitution therapy (1)
- MALAT1 (1)
- OEP80 (1)
- PID prevalence (1)
- Prognostic markers (1)
- Toc75-V (1)
- b-barrel membrane protein (1)
Institute
El-Helou, Sabine M. ; Biegner, Anika-Kerstin ; Bode, Sebastian ; Ehl, Stephan ; Heeg, Maximilian ; Maccari, Maria E. ; Ritterbusch, Henrike ; Speckmann, Carsten ; Rusch, Stephan ; Scheible, Raphael ; Warnatz, Klaus ; Atschekzei, Faranaz ; Beider, Renata ; Ernst, Diana ; Gerschmann, Stev ; Jablonka, Alexandra ; Mielke, Gudrun ; Schmidt, Reinhold E. ; Schürmann, Gesine ; Sogkas, Georgios ; Baumann, Ulrich ; Klemann, Christian ; Viemann, Dorothee ; Bernuth, Horst von ; Krüger, Renate ; Hanitsch, Leif Gunnar ; Scheibenbogen, Carmen ; Wittke, Kirsten ; Albert, Michael H. ; Eichinger, Anna ; Hauck, Fabian ; Klein, Christoph ; Rack-Hoch, Anita ; Sollinger, Franz ; Avila, Anne ; Borte, Michael ; Borte, Stephan ; Fasshauer, Maria ; Hauenherm, Anja ; Kellner, Nils ; Müller, Anna H. ; Ülzen, Anett ; Bader, Peter ; Bakhtiar, Shahrzad ; Lee, Jae-Yun ; Heß, Ursula ; Schubert, Ralf ; Wölke, Sandra ; Zielen, Stefan ; Ghosh, Sujal ; Laws, Hans-Jürgen ; Neubert, Jennifer ; Oommen, Prasad Thomas ; Hönig, Manfred ; Schulz, Ansgar ; Steinmann, Sandra ; Schwarz, Klaus ; Dückers, Gregor ; Lamers, Beate ; Langemeyer, Vanessa ; Niehues, Tim ; Shai, Sonu ; Graf, Dagmar ; Müglich, Carmen ; Schmalzing, Marc ; Schwaneck, Eva C. ; Tony, Hans-Peter ; Dirks, Johannes ; Haase, Gabriele ; Liese, Johannes G. ; Morbach, Henner ; Föll, Dirk ; Hellige, Antje ; Wittkowski, Helmut ; Masjosthusmann, Katja ; Mohr, Michael ; Geberzahn, Linda ; Hedrich, Christian Michael ; Müller, Christiane ; Rösen-Wolff, Angela ; Roesler, Joachim ; Zimmermann, Antje ; Behrends, Uta ; Rieber, Nikolaus ; Schauer, Uwe ; Handgretinger, Rupert ; Holzer, Ursula ; Henes, Jörg Christoph ; Kanz, Lothar ; Boesecke, Christoph ; Rockstroh, Jürgen ; Schwarze-Zander, Carolynne ; Wasmuth, Jan-Christian ; Dilloo, Dagmar ; Hülsmann, Brigitte ; Schönberger, Stefan ; Schreiber, Stefan ; Zeuner, Rainald ; Ankermann, Tobias ; Bismarck, Philipp von ; Huppertz, Hans-Iko ; Kaiser-Labusch, Petra ; Greil, Johann ; Jakoby, Donate ; Kulozik, Andreas ; Metzler, Markus ; Naumann-Bartsch, Nora ; Sobik, Bettina ; Graf, Norbert ; Heine, Sabine ; Kobbe, Robin ; Lehmberg, Kai ; Müller, Ingo ; Herrmann, Friedrich ; Horneff, Gerd ; Klein, Ariane ; Peitz, Joachim ; Schmidt, Nadine ; Bielack, Stefan S. ; Groß-Wieltsch, Ute ; Classen, Carl Friedrich ; Klasen, Jessica ; Deutz, Peter ; Kamitz, Dirk ; Lassay, Lisa ; Tenbrock, Klaus ; Wagner, Norbert ; Bernbeck, Benedikt ; Brummel, Bastian ; Lara-Villacanas, Eusebia ; Münstermann, Esther ; Schneider, Dominik T. ; Tietsch, Nadine ; Westkemper, Marco ; Weiß, Michael ; Kramm, Christof M. ; Kühnle, Ingrid ; Kullman, Silke ; Girschick, Hermann ; Specker, Christof ; Vinnemeier-Laubenthal, Elisabeth ; Haenicke, Henriette ; Schulz, Claudia ; Schweigerer, Lothar ; Müller, Thomas G. ; Stiefel, Martina ; Belohradsky, Bernd H. ; Soetedjo, Veronika ; Kindle, Gerhard ; Grimbacher, Bodo
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
First measurement of 𝚲+c production down to 𝑝T = 0 in pp and p–Pb collisions at √𝑠NN = 5.02 TeV
(2023)
Acharya, Shreyasi ; Adamová, Dagmar ; Adler, Alexander ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akindinov, Alexander ; Al-Turany, Mohammad ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alocco, Giacomo ; Alt, Torsten ; Altsybeev, Igor ; Anaam, Mustafa Naji ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arata, Carolina ; Arcelli, Silvia ; Aresti, Mauro ; Arnaldi, Roberta ; Arneiro, Jhoao Gabriel Martins Campos Almeida ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Badalà, Angela ; Bae, Joonsuk ; Baek, Yong Wook ; Bai, Xiaozhi ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Balbino, Alessandro ; 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Kroesen, Martin ; Krüger, Mario ; Krupová, Diana Maria ; Kryshen, Evgeny ; Kucera, Vit ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kumaoka, Takuya ; Kumar, Deekshit ; Kumar, Lokesh ; Kumar, Navneet ; Kumar, Shyam ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kvapil, Jakub ; Kweon, Min Jung ; Kwon, Jiyeon ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lai, Yue Shi ; Lakrathok, Anantachai ; Lamanna, Massimo ; Langoy, Rune ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Lavicka, Roman ; Lazareva, Tatiana V. ; Lea, Ramona ; Lee, Hyungjun ; Legras, Gauthier ; Lehrbach, Johannes ; Lemmon, Roy Crawford ; Leon Monzon, Ildefonso ; Lesch, Marcel Markus ; Lesser, Ezra Douglas ; Lettrich, Michael ; Lévai, Peter ; Li, X. ; Li, Xing Long ; Lien, Jørgen André ; Lietava, Roman ; Likmeta, Iris ; Lim, Bong-Hwi ; Lim, Sanghoon ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Liu, Alwina Ruixin ; Liu, Donghai ; Liu, Jian ; Mckibben Lofnes, Ingrid ; Loizides, Constantinos ; Lokos, Sandor ; Lomker, Johanna ; Lončar, Petra ; López, Jorge Andres ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Lu, Pengzhong ; Luhder, Jens Robert ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Maevskaya, Alla ; Mager, Magnus ; Mahmoud, Tariq ; Maire, Antonin ; Makariev, Martin Vasilev ; Malaev, Mikhail ; Malfattore, Giovanni ; Malik, Nasir Mehdi ; Malik, Qasim Waheed ; Malik, Salman Khurshid ; Malinina, Liudmila ; Mal Kevich, Dmitry ; Mal’Kevich, Dmitry ; Mallick, Dukhishyam ; Mallick, Neelkamal ; Mandaglio, Giuseppe ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marin, Ana Maria ; Markert, Christina ; Martinengo, Paolo ; Martinez, Jacobb Lee ; Martínez Hernández, Mario Iván ; Martínez Garcia, Ginés ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Matonoha, Oliver ; Matuoka, Paula Fernanda Toledo ; Matyja, Adam Tomasz ; Mayer, Christoph ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Mdhluli, Joyful Elma ; Mechler, Adrian Florin ; Melikyan, Yury ; Menchaca-rocha, Arturo Alejandro ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Meres, Michal ; Mhlanga, Sibaliso ; Miake, Yasuo ; Micheletti, Luca ; Migliorin, Lucrezia Camilla ; Mihaylov, Dimitar Lubomirov ; Mikhaylov, Konstantin ; Mishra, Aditya Nath ; Czeslaw Miskowiec, Dariusz ; Modak, Abhi ; Mohanty, Auro Prasad ; Mohanty, Bedangadas ; Khan, Mohammed Mohisin ; Molander, Mikael Andreas ; Moravcova, Zuzana ; Mordasini, Cindy ; Godoy, Denise Aparecida Moreira de ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Gameiro Munhoz, Marcelo ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nambrath, Anjali Ila ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Naydenov, Momchil Nikolaev ; Neagu, Alexandra ; Negru, Adrian-eduard ; Nellen, Lukas ; Nesbo, Simon Voigt ; Nešković, Gvozden ; Nesterov, Dmitrii ; Nielsen, Borge Svane ; Nielsen, Emil Gorm ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, Seoyoung ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Otwinowski, Jacek Tomasz ; Oya, Motomi ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paic, Guy ; Palasciano, Antonio ; Panebianco, Stefano Matthias ; Park, H. ; Park, H. ; Park, Jonghan ; Parkkila, Jasper Elias ; Patra, Rajendra Nath ; Paul, Biswarup ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pennisi, Michele ; Pereira, Luis Gustavo ; Peresunko, Dmitry Yurevich ; Mesa Perez, Guillermo ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrov, Vitalii ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polishchuk, Boris ; Polichtchouk, Boris ; Politano, Stefano ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf, Sarah Julie ; Porteboeuf-Houssais, Sarah Julie ; Pozdniakov, Valeriy ; Pradhan, Kshitish Kumar ; Prasad, Sidharth Kumar ; Prasad, S. ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Pucillo, Sara ; Pugelova, Zuzana ; Qiu, Shi ; Quaglia, Luca ; Quishpe Quishpe, Raquel Estefania ; Ragoni, Simone ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Rodríguez Ramírez, Saúl Aníbal ; 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Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Seger, Janet Elizabeth ; Sekiguchi, Yuko ; Sekihata, Daiki ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Seo, Jin Joo ; Serebryakov, Dmitry ; Šerkšnytė, Laura ; Sevcenco, Adrian ; Shaba, Tebogo Joyce ; Shabetai, Alexandre ; Shahoyan, Ruben ; Shangaraev, Artem ; Sharma, Anjali ; Sharma, Binti ; Sharma, Deependra ; Sharma, Himanshu ; Sharma, Meenakshi ; Sharma, S. ; Sharma, S. ; Sharma, Upasana ; Shatat, Afnan ; Sheibani, Oveis ; Shigaki, Kenta ; Hachiya Shimomura, Maya ; Shin, Jaehyuck ; Shirinkin, Sergey ; Shou, Qiye ; Sibiryak, Yury ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Silva, Tiago Fiorini da ; Silvermyr, David Olle Rickard ; Simantathammakul, Tawanchat ; Simeonov, Radoslav ; Singh, B. ; Singh, B. ; Singh, R. ; Singh, R. ; Singh, R. ; Singh, Sweta ; Singh, Vivek ; Singhal, Vikas ; Sarkar - Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skorodumovs, Georgijs ; Slupecki, Maciej ; Smirnov, Nikolai ; Snellings, Raimond ; 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Zhang, Xiaoming ; Zhang, Yifei ; Zhang, Zhen ; Zhao, Mingrui ; Zherebchevskii, Vladimir ; Zhi, Y. ; Zhou, Daicui ; Zhou, You ; Zhu, Jianhui ; Zhu, Y. ; Zugravel, Stefan Cristi ; Zurlo, Nicola
The production of prompt Λ+c baryons has been measured at midrapidity in the transverse momentum interval 0<pT<1 GeV/c for the first time, in pp and p-Pb collisions at a centre-of-mass energy per nucleon-nucleon collision sNN−−−√=5.02 TeV. The measurement was performed in the decay channel Λ+c→pK0S by applying new decay reconstruction techniques using a Kalman-Filter vertexing algorithm and adopting a machine-learning approach for the candidate selection. The pT-integrated Λ+c production cross sections in both collision systems were determined and used along with the measured yields in Pb-Pb collisions to compute the pT-integrated nuclear modification factors RpPb and RAA of Λ+c baryons, which are compared to model calculations that consider nuclear modification of the parton distribution functions. The Λ+c/D0 baryon-to-meson yield ratio is reported for pp and p-Pb collisions. Comparisons with models that include modified hadronisation processes are presented, and the implications of the results on the understanding of charm hadronisation in hadronic collisions are discussed. A significant (3.7σ) modification of the mean transverse momentum of Λ+c baryons is seen in p-Pb collisions with respect to pp collisions, while the pT-integrated Λ+c/D0 yield ratio was found to be consistent between the two collision systems within the uncertainties.
First measurement of 𝚲+c production down to 𝑝T = 0 in pp and p–Pb collisions at √𝑠NN = 5.02 TeV
(2023)
Acharya, Shreyasi ; Adamová, Dagmar ; Adler, Alexander ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akindinov, Alexander ; Al-Turany, Mohammad ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alocco, Giacomo ; Alt, Torsten ; Altsybeev, Igor ; Anaam, Mustafa Naji ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arata, Carolina ; Arcelli, Silvia ; Aresti, Mauro ; Arnaldi, Roberta ; Arneiro, Jhoao Gabriel Martins Campos Almeida ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Badalà, Angela ; Bae, Joonsuk ; Baek, Yong Wook ; Bai, Xiaozhi ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Balbino, Alessandro ; 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Ehlers, Raymond James, III ; Eikeland, Viljar Nilsen ; Eisenhut, Florian ; Elia, Domenico ; Erazmus, Barbara Ewa ; Ercolessi, Francesca ; Erhardt, Filip ; Ersdal, Magnus Rentsch ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fan, Wenqing ; Fantoni, Alessandra ; Fasel, Markus ; Fecchio, Pietro ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrandi De Oliveira, Lucas ; Bertran Ferrer, Marta ; Ferrero, Andrea ; Ferrero, Chiara ; Ferretti, Alessandro ; Feuillard, Victor Jose Gaston ; Filova, Vendulka ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Flor, Fernando Antonio ; Flores, Amanda Nicole ; Foertsch, Siegfried Valentin ; Fokin, Ilya ; Fokin, Sergey ; Fragiacomo, Enrico ; Frajna, Eszter ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Fusayasu, Takahiro ; Gaardhoeje, Jens Joergen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Duarte Galvan, Carlos ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Alvarado Garcia, Jesús Ricardo ; Garcia-Solis, Edmundo Javier ; Garg, Kunal ; Gargiulo, Corrado ; Demmich, Katharina ; Garner, Katharina ; Gasik, Piotr ; Gautam, Amrit ; Ducati, Maria Beatriz de Leone Gay ; Ducati, Maria Beatriz de Leone Gay ; Germain, Marie ; Ghimouz, Abderrahmane ; Ghosh, Chandrasekhar ; Giacalone, Marco ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Glimos, Ewa ; Goh, Daniel Jia Qin ; Gonzalez Sebastian, Victor Luis ; González Trueba, Laura Helena ; Gorgon, Marek Boguslaw ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grecka, Ekaterina ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Smbat ; Grosa, Fabrizio ; Gross-Bölting, Simon Johannes ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Grund, David ; Garcia Guardiano, Gabriel ; Guernane, Rachid ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gündem, Tuba ; Gunji, Taku ; Guo, Wenda ; Gupta, Anik ; Gupta, Ramni ; Paisano Guzman, Sergio ; Gyulai, Laszlo ; Habib, Michael Karim ; Hadjidakis, Cynthia Marie ; Haider, Fakhar Ul ; Hamagaki, Hideki ; Hamdi, Abdennacer ; Hamid, Mohammed ; Han, Younghoon ; Hannigan, Ryan ; Haque, Md Rihan ; Harris, John William ; Harton, Austin Vincent ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Havener, Laura Brittany ; Heckel, Stefan Thomas ; Hellbär, Ernst ; Helstrup, Håvard ; Hemmer, Marvin ; Herman, Tomáš ; Herrera Corral, Gerardo Antonio ; Herrmann, Florian ; Herrmann, Sarah Nina Edwige ; Hetland, Kristin Fanebust ; Heybeck, Benedict ; Hillemanns, Hartmut ; Hills, Christopher ; Hippolyte, Boris ; Hoffmann, Felix Willi ; Hofman, Bas ; Hohlweger, Bernhard ; Hong, Geunhee ; Horst, Maximilian ; Horzyk, Adrian ; Hosokawa, Ritsuya ; Hou, Yongzhen ; Hristov, Peter ; Hughes, Charles ; Huhn, Patrick ; Huhta, Laura Maria ; Van Hulse, Charlotte ; Humanic, Thomas J. ; Hutson, Alek ; Hutter, Dirk ; Iddon, James Philip ; Ilkaev, Radiy ; Ilyas, Hira ; Inaba, Motoi ; Innocenti, Gian Michele ; Ippolitov, Mikhail ; Isakov, Artem ; Isidori, Tommaso ; Islam, Md Samsul ; Ivanov, Marian ; Ivanov, Marian ; Ivanov, Vladimir ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Jacobs, Peter Martin ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jaffe, Ludwig Albert ; Jahnke, Cristiane ; Jakubowska, Monika Joanna ; Janik, Malgorzata Anna ; Janson, Thomas ; Jercic, Marko ; Jia, Shihai ; Paz Jimenez, Alom Antonio ; Jonas, Florian ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Junique, Antoine Jean-Simon ; Jusko, Anton ; Kabus, Maja Jadwiga ; Kaewjai, Jetnipit ; Kalinak, Peter ; Kalteyer, Annalena Sophie ; Kalweit, Alexander Philipp ; Kaplin, Vladimir ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karczmarczyk, Przemyslaw ; Karpechev, Evgeny ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, Darius Laurens D. ; Keil, Markus ; Ketzer, Bernhard ; 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The production of prompt Λ+c baryons has been measured at midrapidity in the transverse momentum interval 0<pT<1 GeV/c for the first time, in pp and p-Pb collisions at a centre-of-mass energy per nucleon-nucleon collision sNN−−−√=5.02 TeV. The measurement was performed in the decay channel Λ+c→pK0S by applying new decay reconstruction techniques using a Kalman-Filter vertexing algorithm and adopting a machine-learning approach for the candidate selection. The pT-integrated Λ+c production cross sections in both collision systems were determined and used along with the measured yields in Pb-Pb collisions to compute the pT-integrated nuclear modification factors RpPb and RAA of Λ+c baryons, which are compared to model calculations that consider nuclear modification of the parton distribution functions. The Λ+c/D0 baryon-to-meson yield ratio is reported for pp and p-Pb collisions. Comparisons with models that include modified hadronisation processes are presented, and the implications of the results on the understanding of charm hadronisation in hadronic collisions are discussed. A significant (3.7σ) modification of the mean transverse momentum of Λ+c baryons is seen in p-Pb collisions with respect to pp collisions, while the pT-integrated Λ+c/D0 yield ratio was found to be consistent between the two collision systems within the uncertainties.
First measurement of Λ+c production down to pT = 0 in pp and p-Pb collisions at √𝑠NN = 5.02 TeV
(2023)
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Costa, Filippo ; Costanza, Susanna ; Cot, Corentin ; Crkovská, Jana ; Crochet, Philippe ; Cruz Torres, Reynier ; Cuautle Flores, Eleazar ; Cui, Pengyao ; Dainese, Andrea ; Charlotte Danisch, Meike ; Danu, Andrea ; Das, Prottay ; Das, Prottay ; Das, Supriya ; Rani Dash, Archita ; Dash, Sadhana ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, Suman ; Jan Debski, Roman ; Rafal Deja, Kamil ; Del Grande, Raffaele ; Dello Stritto, Luigi ; Deng, Wenjing ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Arteche Diaz, Raul ; Dietel, Thomas ; Ding, Yanchun ; Divià, Roberto ; Dixit, Dhruv Utpalkumar ; Djuvsland, Øystein ; Dmitrieva, Uliana ; Florin Dobrin, Alexandru ; Donigus, Benjamin ; Dubiński, Jan Michal ; Dubla, Andrea ; Dudi, Sandeep ; Dupieux, Pascal ; Durkac, Martin ; Dzalaiova, Natalia ; Maria Eder, Tabea ; Raymond James, III Ehlers ; Nilsen Eikeland, Viljar ; Eisenhut, Florian ; Elia, Domenico ; Ewa Erazmus, Barbara ; Ercolessi, Francesca ; Erhardt, Filip ; Rentsch Ersdal, Magnus ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fan, Wenqing ; Fantoni, Alessandra ; Fasel, Markus ; Fecchio, Pietro ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrandi De Oliveira, Lucas ; Bertran Ferrer, Marta ; Ferrero, Andrea ; Ferrero, Chiara ; Ferretti, Alessandro ; Feuillard, Victor Jose Gaston ; Filova, Vendulka ; Finogeev, Dmitry ; Maria Celeste Fionda, Fiorella ; Antonio Flor, Fernando ; Nicole Flores, Amanda ; Foertsch, Siegfried Valentin ; Fokin, Ilya ; Fokin, Sergey ; Fragiacomo, Enrico ; Frajna, Eszter ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Fusayasu, Takahiro ; Gaardhøje, Jens Jørgen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Duarte Galvan, Carlos ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Ricardo Alvarado Garcia, Jesus ; Javier Garcia-Solis, Edmundo ; Garg, Kunal ; Gargiulo, Corrado ; Demmich, Katharina ; Garner, Katharina ; Gasik, Piotr ; Gautam, Amrit ; Beatriz de Leone Gay Ducati, Maria ; Beatriz de Leone Gay Ducati, Maria ; Germain, Marie ; Ghimouz, Abderrahmane ; Ghosh, Chandrasekhar ; Giacalone, Marco ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Glimos, Ewa ; Jia Qin Goh, Daniel ; Luis Gonzalez Sebastian, Victor ; Helena Gonzalez Trueba, Laura ; Boguslaw Gorgon, Marek ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grecka, Ekaterina ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Smbat ; Grosa, Fabrizio ; Johannes Gross-Bölting, Simon ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Grund, David ; Garcia Guardiano, Gabriel ; Guernane, Rachid ; Rene Joseph Guilbaud, Maxime ; Herlache Gulbrandsen, Kristjan ; Gündem, Tuba ; Gunji, Taku ; Guo, Wenda ; Gupta, Anik ; Gupta, Ramni ; Paisano Guzman, Sergio ; Gyulai, Laszlo ; Karim Habib, Michael ; Marie Hadjidakis, Cynthia ; Ul Haider, Fakhar ; Hamagaki, Hideki ; Hamdi, Abdennacer ; Hamid, Mohammed ; Han, Younghoon ; Hannigan, Ryan ; Rihan Haque, Md ; William Harris, John ; Vincent Harton, Austin ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Brittany Havener, Laura ; Heckel, Stefan Thomas ; Hellbär, Ernst ; Helstrup, Håvard ; Hemmer, Marvin ; Herman, Tomáš ; Antonio Herrera Corral, Gerardo ; Herrmann, Florian ; Nina Edwige Herrmann, Sarah ; Hetland, Kristin Fanebust ; Heybeck, Benedict ; Hillemanns, Hartmut ; Hills, Christopher ; Hippolyte, Boris ; Willi Hoffmann, Felix ; Hofman, Bas ; Hohlweger, Bernhard ; Hong, Geunhee ; Horst, Maximilian ; Horzyk, Adrian ; Hosokawa, Ritsuya ; Hou, Yongzhen ; Hristov, Peter ; Hughes, Charles ; Huhn, Patrick ; Maria Huhta, Laura ; Van Hulse, Charlotte ; Humanic, Thomas J. ; Hutson, Alek ; Hutter, Dirk ; Philip Iddon, James ; Ilkaev, Radiy ; Ilyas, Hira ; Inaba, Motoi ; Michele Innocenti, Gian ; Ippolitov, Mikhail ; Isakov, Artem ; Isidori, Tommaso ; Samsul Islam, Md ; Ivanov, Marian ; Ivanov, Marian ; Ivanov, Vladimir ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Martin Jacobs, Peter ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jaffe, Ludwig Albert ; Jahnke, Cristiane ; Joanna Jakubowska, Monika ; Anna Janik, Malgorzata ; Janson, Thomas ; Jercic, Marko ; Jia, Shihai ; Antonio Paz Jimenez, Alom ; Jonas, Florian ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Jean-Simon Junique, Antoine ; Jusko, Anton ; Jadwiga Kabus, Maja ; Kaewjai, Jetnipit ; Kalinak, Peter ; Sophie Kalteyer, Annalena ; Philipp Kalweit, Alexander ; Kaplin, Vladimir ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karczmarczyk, Przemyslaw ; Karpechev, Evgeny ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, Darius Laurens D. ; Keil, Markus ; Ketzer, Bernhard ; Mehmood Khan, Ahsan ; Khan, Shaista ; Khanzadeev, Alexei ; Kharlov, Yury ; Khatun, Anisa ; Khuntia, Arvind ; Brower Kidson, Miles ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Chong ; Jo Kim, Dong ; Joo Kim, Eun ; Kim, J. ; Kim, J.S. ; Kim, J. ; Kim, Minjung ; Yong Kim, Se ; Kim, Taejun ; Kimura, Kento ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Ryszard Kisiel, Adam ; Pawel Kitowski, Jacek ; Lynn Klay, Jennifer ; Klein, Jochen ; Robert Klein, Spencer ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Garritt Knospe, Anders ; Kobdaj, Chinorat ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia ; Kondratyuk, Evgeny ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Koryciak, Sebastian Dominik ; Kotliarov, Artem ; Kovalenko, Vladimir ; Kowalski, Marek ; Valeriev Kozhuharov, Venelin ; Králik, Ivan ; Kravčáková, Adela ; Kreis, Lukas ; Krivda, Marian ; Krizek, Filip ; Krizkova Gajdosova, Katarina ; Kroesen, Martin ; Krüger, Mario ; Maria Krupova, Diana ; Kryshen, Evgeny ; Kucera, Vit ; Claude Kuhn, Christian ; Gerardus Kuijer, Paulus ; Kumaoka, Takuya ; Kumar, Deekshit ; Kumar, Lokesh ; Kumar, Navneet ; Kumar, Shyam ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kvapil, Jakub ; Jung Kweon, Min ; Kwon, Jiyeon ; Kwon, Youngil ; Louise La Pointe, Sarah ; La Rocca, Paola ; Shi Lai, Yue ; Lakrathok, Anantachai ; Lamanna, Massimo ; Langoy, Rune ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Lavicka, Roman ; Lazareva, Tatiana V. ; Lea, Ramona ; Lee, Hyungjun ; Legras, Gauthier ; Lehrbach, Johannes ; Crawford Lemmon, Roy ; Leon Monzon, Ildefonso ; Markus Lesch, Marcel ; Douglas Lesser, Ezra ; Lettrich, Michael ; Lévai, Peter ; Li, X. ; Long Li, Xing ; Andre Lien, Jørgen ; Lietava, Roman ; Likmeta, Iris ; Lim, Bong-Hwi ; Lim, Sanghoon ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Ruixin Liu, Alwina ; Liu, Donghai ; Liu, Jian ; Mckibben Lofnes, Ingrid ; Loizides, Constantinos ; Lokos, Sandor ; Lomker, Johanna ; Lončar, Petra ; Andres Lopez, Jorge ; Bernard Lopez, Xavier ; López Torres, Ernesto ; Lu, Pengzhong ; Robert Luhder, Jens ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Maevskaya, Alla ; Mager, Magnus ; Mahmoud, Tariq ; Maire, Antonin ; Vasilev Makariev, Martin ; Malaev, Mikhail ; Malfattore, Giovanni ; Malik, Nasir Mehdi ; Malik, Qasim Waheed ; Malik, Salman Khurshid ; Malinina, Liudmila ; Mal Kevich, Dmitry ; Mal’Kevich, Dmitry ; Mallick, Dukhishyam ; Mallick, Neelkamal ; Mandaglio, Giuseppe ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Maria Marin, Ana ; Markert, Christina ; Martinengo, Paolo ; Lee Martinez, Jacobb ; Ivan Martinez Hernandez, Mario ; García Martínez, Ginés ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Marie Massacrier, Laure ; Mastroserio, Annalisa ; Matonoha, Oliver ; Fernanda Toledo Matuoka, Paula ; Tomasz Matyja, Adam ; Mayer, Christoph ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Elma Mdhluli, Joyful ; Florin Mechler, Adrian ; Melikyan, Yury ; Alejandro Menchaca-rocha, Arturo ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Meres, Michal ; Mhlanga, Sibaliso ; Miake, Yasuo ; Micheletti, Luca ; Camilla Migliorin, Lucrezia ; Lubomirov Mihaylov, Dimitar ; Mikhaylov, Konstantin ; Nath Mishra, Aditya ; Czeslaw Miskowiec, Dariusz ; Modak, Abhi ; Prasad Mohanty, Auro ; Mohanty, Bedangadas ; Mohisin Khan, Mohammed ; Andreas Molander, Mikael ; Moravcova, Zuzana ; Mordasini, Cindy ; Aparecida Moreira de Godoy, Denise ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Muhuri, Sanjib ; Declan Mulligan, James ; Mulliri, Alice ; Gameiro Munhoz, Marcelo ; Helmut Munzer, Robert ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Wojciech Myrcha, Julian ; Naik, Bharati ; Ila Nambrath, Anjali ; Kumar Nandi, Basanta ; Nania, Rosario ; Nappi, Eugenio ; Fereydon Nassirpour, Adrian ; Nath, Abhishek ; Nattrass, Christine ; Nikolaev Naydenov, Momchil ; Neagu, Alexandra ; Negru, Adrian-eduard ; Nellen, Lukas ; Voigt Nesbo, Simon ; Nešković, Gvozden ; Nesterov, Dmitrii ; Svane Nielsen, Borge ; Gorm Nielsen, Emil ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, Seoyoung ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Ogino, Masanori ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Carlos Oliveira da Silva, Antonio ; Henry Oliver, Michael ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Tomasz Otwinowski, Jacek ; Oya, Motomi ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paic, Guy ; Palasciano, Antonio ; Panebianco, Stefano Matthias ; Park, H. ; Park, H. ; Park, Jonghan ; Elias Parkkila, Jasper ; Nath Patra, Rajendra ; Paul, Biswarup ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pennisi, Michele ; Gustavo Pereira, Luis ; Yurevich Peresunko, Dmitry ; Mesa Perez, Guillermo ; Perrin, Sébastien ; Pestov, Yury N. ; Petráček, Vojtech ; Petrov, Vitalii ; Petrovici, Mihai A. ; Pezzi, Rafael Peretti ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polishchuk, Boris ; Polichtchouk, Boris ; Politano, Stefano ; Poljak, Nikola ; Pop, Amalia ; Julie Porteboeuf, Sarah ; Porteboeuf-Houssais, Sarah Julie ; Pozdniakov, Valeriy ; Kumar Pradhan, Kshitish ; Prasad, Sidharth Kumar ; Prasad, S. ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Pucillo, Sara ; Pugelova, Zuzana ; Qiu, Shi ; Quaglia, Luca ; Estefania Quishpe Quishpe, Raquel ; Ragoni, Simone ; Malala Rakotozafindrabe, Andry ; Ramello, Luciano ; Rami, Fouad ; Anibal Rodriguez Ramirez, Saul ; Albert Rancien, Thibaut ; Rasa, Marika ; Sakari Räsänen, Sami ; Rath, Rutuparna ; Philip Rauch, Max ; Ravasenga, Ivan ; Francis Read, Kenneth ; Reckziegel, Christian ; Ralph Redelbach, Andreas ; Redlich, Krzysztof ; Anna Reetz, Carolina ; ur Rehman, Attiq ; Reidt, Felix ; Andre Reme-Ness, Haakon ; Jakubcinova, Zuzana ; Rescakova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor ; Ricci, Riccardo ; Richter, Matthias ; Albert Riedel, Anton ; Riegler, Werner ; Ristea, Cătălin-Lucian ; Rodrı́guez Cahuantzi, Mario ; Røed, Ketil ; Røed, Ketil ; Rogalev, Roman ; Rogochaya, Elena ; Rogoschinski, Tim Sebastian ; Rohr, David ; Röhrich, Dieter ; Fierro Rojas, Pablo ; Rojas Torres, Solangel ; Stefan Rokita, Przemyslaw ; Romanenko, Gleb ; Ronchetti, Federico ; Rosano, Antonina ; Dominguez Rosas, Edgar ; Rosłon, Krystian ; Rossi, Andrea ; Roy, Ankhi ; Roy, Subhadeep ; Rubini, Nicola ; Vazquez Rueda, Omar ; Ruggiano, Daniela ; Rui, Rinaldo ; Rumyantsev, Boris ; Russek, Paweł Grzegorz ; Russo, Roberto ; Rustamov, Anar ; Ryabinkin, Evgeny ; Ryabov, Yury ; Rybicki, Andrzej ; Maria Rytkönen, Heidi ; Rzęsa, Wioleta ; Saarimäki, Oskari Antti Matti ; Sadek, Rita ; Sadhu, Samrangy ; Sadovskiy, Sergey ; Sætre, Jon-are ; Šafařík, Karel ; Kumar Saha, Sumit ; Saha, Swati ; Sahoo, Baidyanath ; Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Dushmanta ; Kumar Sahu, Pradip ; Saini, Jogender ; Sajdakova, K. ; Tropp, Klaudia ; Sakai, Shingo ; Panikkassery Salvan, Malavika ; Singh Sambyal, Sanjeev ; Sanna, Isabella ; Saramela, Thiago Badaró ; Sarkar, Debojit ; Sarkar, Nachiketa ; Sarma, Pranjal ; Sarritzu, Valerio ; Mantovani Sarti, Valentina ; Henry Petrus Sas, Mike ; Joachim Schambach, Johann ; Sebastian Scheid, Horst ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmah, Alexander ; Joachim Schmidt, Christian ; Rudolf Schmidt, Hans ; Ole Schmidt, Marten ; Schmidt, M. ; Schmidt, Nicolas ; Schmier, Austin Robert ; Schotter, Romain ; Schroter, Alexander ; Schukraft, Jürgen ; Eberhard Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Elizabeth Seger, Janet ; Sekiguchi, Yuko ; Sekihata, Daiki ; Selyuzhenkov, Ilya ; Senyukov, Serhiy ; Joo Seo, Jin ; Serebryakov, Dmitry ; Šerkšnytė, Laura ; Sevcenco, Adrian ; Shaba, Tebogo Joyce ; Shabetai, Alexandre ; Shahoyan, Ruben ; Shangaraev, Artem ; Sharma, Anjali ; Sharma, Binti ; Sharma, Deependra ; Sharma, Himanshu ; Sharma, Meenakshi ; Sharma, S. ; Sharma, S. ; Sharma, Upasana ; Shatat, Afnan ; Sheibani, Oveis ; Shigaki, Kenta ; Hachiya Shimomura, Maya ; Shin, Jaehyuck ; Shirinkin, Sergey ; Shou, Qiye ; Sibiryak, Yury ; Siddhanta, Sabyasachi ; Siemiarczuk, Teodor ; Silva, Tiago Fiorini da ; Olle Rickard Silvermyr, David ; Simantathammakul, Tawanchat ; Simeonov, Radoslav ; Singh, B. ; Singh, B. ; Singh, R. ; Singh, R. ; Singh, R. ; Singh, Sweta ; Singh, Vivek ; Singhal, Vikas ; Sarkar-Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skorodumovs, Georgijs ; Slupecki, Maciej ; Smirnov, Nikolai ; Snellings, Raimond ; Solheim, Emilie ; Song, Jihye ; Songmoolnak, Arnon ; Soramel, Francesca ; Spijkers, Rik ; Anna Sputowska, Iwona ; Staa, Joey ; Stachel, Johanna ; Stan, Ionel ; John Steffanic, Patrick ; Stiefelmaier, Stephan ; Stocco, Diego ; Storehaug, Ida ; Stratmann, Peter ; Strazzi, Sofia ; Pliatskas Stylianidis, Christos ; Suaide, Alexandre Alarcon do Passo ; Suire, Christophe Pierre ; Sukhanov, Mikhail ; Šuljić, Miljenko ; Sultanov, Rishat ; Sumberia, Vikash ; Sumowidagdo, Suharyo ; Swain, Sagarika ; Szarka, Imrich ; Szymkowski, Maciej ; Taghavi, Seyed Farid ; Taillepied, Guillaume ; Takahashi, Jun ; Tambave, Ganesh ; Tang, Siyu ; Tang, Zebo ; Tapia Takaki, Jesus Daniel ; Țăpuş, Nicolae ; Anna Tarasovicova, Lucia ; Tarzila, Madalina-Gabriela ; Francesco Tassielli, Giovanni ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terlizzi, Livia ; Terrevoli, Cristina ; Tersimonov, Georgy ; Thakur, Sanchari ; Thomas, Deepa ; Tikhonov, Anatoly ; Timmins, Anthony Robert ; Tkacik, Milan ; Tkacik, Tomas ; Toia, Alberica ; Tokumoto, Ryoka ; Topilskaya, Nataliya ; Toppi, Marco ; Torales Acosta, Fernando ; Tork, Theraa M.A. ; Grisel Torres Ramos, Arianna ; Trifiro, Antonio ; Sofia Triolo, Andrea ; Tripathy, Sushanta ; Tripathy, Tulika ; Trogolo, Stefano ; Trubnikov, Victor ; Trzaska, Wladyslaw Henryk ; Trzcinski, Tomasz Piotr ; Tumkin, Alexandr ; Turrisi, Rosario ; Spedstad Tveter, Trine ; Ullaland, Kjetil ; Ulukutlu, Berkin ; Uras, Antonio ; Urioni, Marta ; Usai, Gianluca ; Vala, Martin ; Valle, Nicolò ; Doremalen, Lennart Vincent Rogier van ; Leeuwen, Marco van ; Arie Van Veen, Casper ; Jan Gijs van Weelden, Roelof ; Vyvre, Pierre vande ; Varga, Dezsö ; Varga, Zoltán ; Vasileiou, Maria ; Vasiliev, Andrey ; Vázquez Doce, Oton ; Vechernin, Vladimir ; Vercellin, Ermanno ; Vergara Limon, Sergio ; Vermunt, Lucas Anne ; Vértesi, Róbert ; Verweij, Marta ; Vicković, Linda ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Villani, Anna ; Vino, Gioacchino ; Vinogradov, Alexander ; Virgili, Tiziano ; Vislavicius, Vytautas ; Vodopyanov, Alexander ; Völkel, Benedikt ; Völkl, Martin Andreas ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vorobyev, Ivan ; Vozniuk, Nikita ; Vrláková, Janka ; Wang, Chunzheng ; Wang, Dongfang ; Wang, Yuanzhe ; Tadeusz Wegrzynek, Adami ; Weiglhofer, Felix Thomas ; Wenzel, Sandro Christian ; Wessels, Johannes P. ; Lisa Weyhmiller, Sierra ; Wiechula, Jens ; Wikne, Jon ; Andrzej Wilk, Grzegorz ; John Wilkinson, Jeremy ; Alexander Willems, Guido ; Windelband, Bernd ; Winn, Michael ; Rae Wright, Josephina ; Wu, Wenya ; Wu, Yitao ; Xu, Ran ; Yadav, Ankur ; Kumar Yadav, Arun ; Yalcin Kuzu, Serpil ; Yamaguchi, Yorito ; Yang, Shiming ; Yano, Satoshi ; Yin, Zhongbao ; Yoo, In-Kwon ; Hee Yoon, Jin ; Yuan, Shiming ; Yüncü, Alperen ; Zaccolo, Valentina ; Zampolli, Chiara ; Zanone, Federica ; Zardoshti, Nima ; Zarochentsev, Andrey ; Závada, Petr ; Zavyalov, Nikolay ; Zhalov, Mikhail ; Zhang, Biao ; Zhang, Liuyao ; Zhang, Song ; Zhang, Xiaoming ; Zhang, Yifei ; Zhang, Zhen ; Zhao, Mingrui ; Zherebchevskii, Vladimir ; Zhi, Y. ; Zhou, Daicui ; Zhou, You ; Zhu, Jianhui ; Zhu, Y. ; Zugravel, Stefan Cristi ; Zurlo, Nicola
The production of prompt +c baryons has been measured at midrapidity in the transverse momentum interval 0 < pT < 1 GeV/c for the first time, in pp and p–Pb collisions at a center-of-mass energy per nucleon-nucleon collision √sNN = 5.02 TeV. The measurement was performed in the decay channel +c → pK0S by applying new decay reconstruction techniques using a Kalman-Filter vertexing algorithm and adopting a machine-learning approach for the candidate selection. The pT -integrated +c production cross sections in both collision systems were determined and used along with the measured yields in Pb–Pb collisions to compute the pT -integrated nuclear modification factors RpPb and RAA of +c baryons, which are compared to model calculations that consider nuclear modification of the parton distribution functions. The +c /D0 baryon-to-meson yield ratio is reported for pp and p–Pb collisions. Comparisons with models that include modified hadronization processes are presented, and the implications of the results on the understanding of charm hadronization in hadronic collisions are discussed. A significant (3.7σ) modification of the mean transverse momentum of + c baryons is seen in p–Pb collisions with respect to pp collisions, while the pT -integrated +c /D0 yield ratio was found to be consistent between the two collision systems within the uncertainties.
The insertion of membrane proteins requires proteinaceous complexes in the cytoplasm, the membrane, and the lumen of organelles. Most of the required complexes have been described, while the components for insertion of β‐barrel‐type proteins into the outer membrane of chloroplasts remain unknown. The same holds true for the signals required for the insertion of β‐barrel‐type proteins. At present, only the processing of Toc75‐III, the β‐barrel‐type protein of the central chloroplast translocon with an atypical signal, has been explored in detail. However, it has been debated whether Toc75‐V/ outer envelope protein 80 (OEP80), a second protein of the same family, contains a signal and undergoes processing. To substantiate the hypothesis that Toc75‐V/OEP80 is processed as well, we reinvestigated the processing in a protoplast‐based assay as well as in native membranes. Our results confirm the existence of a cleavable segment. By protease protection and pegylation, we observed intermembrane space localization of the soluble N‐terminal domain. Thus, Toc75‐V contains a cleavable N‐terminal signal and exposes its polypeptide transport‐associated domains to the intermembrane space of plastids, where it likely interacts with its substrates.
Winter, Nils R. ; Blanke, Julian ; Leenings, Ramona ; Ernsting, Jan ; Fisch, Lukas ; Sarink, Kelvin ; Barkhau, Carlotta ; Thiel, Katharina ; Flinkenflügel, Kira ; Winter, Alexandra ; Goltermann, Janik ; Meinert, Susanne ; Dohm, Katharina ; Repple, Jonathan ; Gruber, Marius ; Leehr, Elisabeth Johanna ; Opel, Nils ; Grotegerd, Dominik ; Redlich, Ronny ; Nitsch, Robert ; Bauer, Jochen ; Heindel, Walter ; Groß, Joachim ; Andlauer, Till ; Forstner, Andreas Josef ; Nöthen, Markus Maria ; Rietschel, Marcella ; Hofmann, Stefan G. ; Pfarr, Julia-Katharina ; Teutenberg, Lea ; Usemann, Paula ; Thomas-Odenthal, Florian ; Wroblewski, Adrian ; Brosch, Katharina ; Stein, Frederike ; Jansen, Andreas ; Jamalabadi, Hamidreza ; Alexander, Nina ; Straube, Benjamin ; Nenadić, Igor ; Kircher, Tilo ; Dannlowski, Udo ; Hahn, Tim
Background: Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, Major Depressive Disorder (MDD), patients only marginally differ from healthy individuals on the group-level. Whether Precision Psychiatry can solve this discrepancy and provide specific, reliable biomarkers remains unclear as current Machine Learning (ML) studies suffer from shortcomings pertaining to methods and data, which lead to substantial over-as well as underestimation of true model accuracy.
Methods: Addressing these issues, we quantify classification accuracy on a single-subject level in N=1,801 patients with MDD and healthy controls employing an extensive multivariate approach across a comprehensive range of neuroimaging modalities in a well-curated cohort, including structural and functional Magnetic Resonance Imaging, Diffusion Tensor Imaging as well as a polygenic risk score for depression.
Findings Training and testing a total of 2.4 million ML models, we find accuracies for diagnostic classification between 48.1% and 62.0%. Multimodal data integration of all neuroimaging modalities does not improve model performance. Similarly, training ML models on individuals stratified based on age, sex, or remission status does not lead to better classification. Even under simulated conditions of perfect reliability, performance does not substantially improve. Importantly, model error analysis identifies symptom severity as one potential target for MDD subgroup identification.
Interpretation: Although multivariate neuroimaging markers increase predictive power compared to univariate analyses, single-subject classification – even under conditions of extensive, best-practice Machine Learning optimization in a large, harmonized sample of patients diagnosed using state-of-the-art clinical assessments – does not reach clinically relevant performance. Based on this evidence, we sketch a course of action for Precision Psychiatry and future MDD biomarker research.
Improved risk stratification in prevention by use of a panel of selected circulating microRNAs
(2017)
Keller, Till ; Boeckel, Jes-Niels ; Groß, Stefan ; Klotsche, Jens ; Palapies, Lars ; Leistner, David ; Pieper, Lars ; Stalla, Günnter K. ; Lehnert, Hendrik ; Silber, Sigmund ; Pittrow, David ; März, Winfried ; Dörr, Marcus ; Wittchen, Hans-Ulrich ; Baumeister, Sebastian E. ; Völker, Uwe ; Felix, Stephan B. ; Dimmeler, Stefanie ; Zeiher, Andreas M.
Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 and miR-133 were determined from peripheral blood by qPCR and combined to a risk panel. As derivation cohort, 178 individuals of the DETECT study, and as validation cohort, 129 individuals of the SHIP study were used in a case-control approach. Overall mortality and cardiovascular events were outcome measures. The Framingham Risk Score(FRS) and the SCORE system were applied as risk classification systems. The identified miR panel was significantly associated with mortality given by a hazard ratio(HR) of 3.0 (95% (CI): 1.09–8.43; p = 0.034) and of 2.9 (95% CI: 1.32–6.33; p = 0.008) after adjusting for the FRS in the derivation cohort. In a validation cohort the miR-panel had a HR of 1.31 (95% CI: 1.03–1.66; p = 0.03) and of 1.29 (95% CI: 1.02–1.64; p = 0.03) in a FRS/SCORE adjusted-model. A FRS/SCORE risk model was significantly improved to predict mortality by the miR panel with continuous net reclassification index of 0.42/0.49 (p = 0.014/0.005). The present miR panel of 5 circulating miRs is able to improve risk stratification in prevention with respect to mortality beyond the FRS or SCORE.
Eißmann, Moritz ; Gutschner, Tony ; Hämmerle, Monika ; Günther, Stefan ; Caudron-Herge, Maïwen ; Groß, Matthias ; Schirmacher, Peter ; Rippe, Karsten ; Braun, Thomas ; Diederichs, Sven ; Zörnig, Martin
The metastasis-associated lung adenocarcinoma transcript 1, MALAT1, is a long non-coding RNA (lncRNA) that has been discovered as a marker for lung cancer metastasis. It is highly abundant, its expression is strongly regulated in many tumor entities including lung adenocarcinoma and hepatocellular carcinoma as well as physiological processes, and it is associated with many RNA binding proteins and highly conserved throughout evolution. The nuclear transcript MALAT-1 has been functionally associated with gene regulation and alternative splicing and its regulation has been shown to impact proliferation, apoptosis, migration and invasion.
Here, we have developed a human and a mouse knockout system to study the loss-of-function phenotypes of this important ncRNA. In human tumor cells, MALAT1 expression was abrogated using Zinc Finger Nucleases. Unexpectedly, the quantitative loss of MALAT1 did neither affect proliferation nor cell cycle progression nor nuclear architecture in human lung or liver cancer cells. Moreover, genetic loss of Malat1 in a knockout mouse model did not give rise to any obvious phenotype or histological abnormalities in Malat1-null compared with wild-type animals. Thus, loss of the abundant nuclear long ncRNA MALAT1 is compatible with cell viability and normal development.
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