Refine
Author
- Adachi, T. (1)
- Aksouh, Farouk (1)
- Al-Khalili, J. (1)
- AlGarawi, M. (1)
- AlGhamdi, S. (1)
- Alkhazov, G. (1)
- Alkhomashi, N. (1)
- Altstadt, Sebastian (1)
- Alvarez-Pol, Héctor (1)
- Alvarez-Rodriguez, R. (1)
- Andreev, V. (1)
- Andrei, B. (1)
- Arakelyan, Arsen (1)
- Atar, Leyla (1)
- Aumann, Thomas (1)
- Avdeichikov, Vladimir (1)
- Bacri, C. (1)
- Bagchi, S. (1)
- Barbieri, Carlo (1)
- Beceiro, Saul (1)
- Beck, C. (1)
- Beinrucker, Clemens (1)
- Belier, Gilbert (1)
- Bemmerer, Daniel (1)
- Bendel, M. (1)
- Benlliure Anaya, Jose Fernando (1)
- Benzoni, G. (1)
- Berjillos, R. (1)
- Bertini, D. (1)
- Bertulani, Carlos A. (1)
- Binder, Hans (1)
- Bishop, S. (1)
- Blasi, N. (1)
- Bleis, T.Le (1)
- Bloch, T. (1)
- Blumenfeld, Y. (1)
- Bonaccorso, A. (1)
- Boretzky, Konstanze (1)
- Botvina, Alexander (1)
- Boudard, A. (1)
- Boutachkov, P. (1)
- Boztosun, I. (1)
- Bracco, A. (1)
- Brambilla, S. (1)
- Caamano, Manuel (1)
- Caesar, Christoph (1)
- Camera, F. (1)
- Casarejos Ruiz, Enrique (1)
- Catford, Wilton N. (1)
- Cederkäll, Joakim (1)
- Cederwall, B. (1)
- Chartier, Marielle (1)
- Chatillon, Audrey (1)
- Cherciu, M. (1)
- Chulkov, Leonid V. (1)
- Cogliatti, Sergio B. (1)
- Coleman-Smith, P. (1)
- Cortina Gil, Dolores (1)
- Crespi, F. (1)
- Crespo, Raquel (1)
- Cresswell, J. (1)
- Csatlós, Margit (1)
- Davids, B. (1)
- Davinson, Thomas (1)
- Derya, Vera (1)
- Detistov, P. (1)
- DiJulio, D. (1)
- Dmitry, S. (1)
- Doré, D. (1)
- Dueñas, J. (1)
- Dupont, Emmeric (1)
- Déchery, F. (1)
- Díaz Fernández, Paloma (1)
- Egelhof, Peter (1)
- Egorova, I. (1)
- Elekes, Zoltán (1)
- Enders, Joachim (1)
- Endres, Janis (1)
- Ershov, S. (1)
- Ershova, Olga (1)
- Feller, Alfred Christian (1)
- Fernández Domínguez, Beatriz (1)
- Fetisov, A. (1)
- Fiori, Enrico (1)
- Fomichev, A. (1)
- Fonseca, M. (1)
- Fortenbacher, Erik (1)
- Fraile, L. (1)
- Freer, Martin (1)
- Friese, Jürgen (1)
- Galaviz Redondo, Daniel (1)
- Gannon, S. (1)
- Garcia Borge, Maria José (1)
- Garg, U. (1)
- Gasques, L. (1)
- Gastineau, B. (1)
- Gašparić, Igor (1)
- Geissel, Hans (1)
- Gernhäuser, Roman (1)
- Ghosh, T. (1)
- Gilbert, M. (1)
- Glorius, Jan (1)
- Golubev, Pavel (1)
- Gorshkov, Alexander (1)
- Gourishetty, A. (1)
- Grigorenko, Leonid V. (1)
- Gulyas, J. (1)
- Göbel, Kathrin (1)
- Haake, Andrea (1)
- Haiduc, Maria (1)
- Hammache, F. (1)
- Hansmann, Martin-Leo (1)
- Harakeh, Muhsin N. (1)
- Hass, M. (1)
- Heftrich, Tanja (1)
- Heil, Michael (1)
- Heine, Marcel (1)
- Hennig, Andreas (1)
- Henriques, Ana (1)
- Herraiz, J.Lopez (1)
- Herzberg, Rolf-Dietmar (1)
- Holl, Matthias (1)
- Hopp, Lydia (1)
- Hummel, Michael (1)
- Ignatov, Alexander (1)
- Ignatyuk, A. (1)
- Ilieva, Stoyanka (1)
- Ivanov, Marian (1)
- Iwasa, N. (1)
- Jakobsson, B. (1)
- Johansson, Håkan T. (1)
- Jonson, Björn (1)
- Joshi, P. (1)
- Junghans, Arnd Rudolf (1)
- Jurado Apruzzese, Beatriz (1)
- Kalantar, N. (1)
- Kanungo, Rituparna (1)
- Kelic-Heil, Aleksandra (1)
- Kezzar, K. (1)
- Khan, E. (1)
- Khanzadeev, Alexei (1)
- Kiselev, Oleg A. (1)
- Klapper, Wolfram (1)
- Kogimtzis, M. (1)
- Koloczek, Alexander (1)
- Krasznahorkay, Attila (1)
- Kratz, Jens-Volker (1)
- Kresan, Dmytro (1)
- Kreuz, Markus (1)
- Krings, Thomas (1)
- Krumbholz, A. (1)
- Krupko, S. (1)
- Kräckmann, S. (1)
- Kröll, Thorsten (1)
- Krücken, Reiner (1)
- Kulessa, Reinhard (1)
- Kumar, Shyam (1)
- Kurz, Nikolaus (1)
- Kuzmin, E. (1)
- Körner, G. (1)
- Körper, D. (1)
- Labiche, Marc (1)
- Langanke, Karlheinz (1)
- Langer, Christoph (1)
- Lazarus, I. (1)
- Lederer, Claudia (1)
- Lemasson, A. (1)
- Lemmon, Roy Crawford (1)
- Lenze, Dido (1)
- Liberati, V. (1)
- Litvinov, Yuri A. (1)
- Löffler, Markus (1)
- Löffler-Wirth, Henry (1)
- Löher, Bastian (1)
- Machado, Jorge (1)
- Maev, E. (1)
- Mahata, Kripamay (1)
- Mancusi, D. (1)
- Marganiec, Justyna (1)
- Marusov, V. (1)
- Mengoni, D. (1)
- Million, B. (1)
- Monago, J.Briz (1)
- Morcelle, V. (1)
- Moreno, O. (1)
- Movsesyan, Alina (1)
- Möller, Peter (1)
- Müller-Hermelink, Hans Konrad (1)
- Münzenberg, G. (1)
- Najafi, Mohammad Ali (1)
- Nakamura, T. (1)
- Naqvi, F. (1)
- Neumann-Cosel, Peter von (1)
- Nikolski, E. (1)
- Nilsson, Thomas (1)
- Nociforo, Chiara (1)
- Nolan, P. (1)
- Novatsky, B. (1)
- Nyman, Göran Hugo (1)
- Nácher González, Enrique (1)
- Ornelas, A. (1)
- Ott, German (1)
- Palit, R. (1)
- Pandit, S. (1)
- Panin, Valerii (1)
- Paradela Dobarro, Carlos (1)
- Parkar, V. (1)
- Paschalis, Stefanos (1)
- Pawłowski, P. (1)
- Perea Martinez, Angel (1)
- Pereira, J. (1)
- Perez, M.Martinez (1)
- Petrache, C. (1)
- Petri, Marina (1)
- Pickstone, Simon Glynn (1)
- Pietralla, Norbert (1)
- Pietri, Stephane (1)
- Pivovarov, Y. (1)
- Plag, Ralf (1)
- Pohl, M. (1)
- Potlog, P. (1)
- Pott, Christiane (1)
- Prokofiev, Andrey (1)
- Rastrepina, G. (1)
- Rauscher, Thomas (1)
- Reifarth, René (1)
- Ribeiro Jimenez, Guillermo (1)
- Ricciardi, Maria Valentina (1)
- Richter, Achim (1)
- Rigollet, Catherine (1)
- Riisager, Karsten (1)
- Rios, A. (1)
- Ritter, C. (1)
- Rodríguez Frutos, Tomás Raúl (1)
- Rodríguez Vignote, Javier (1)
- Romig, Christopher (1)
- Rosado, J.Sanchez (1)
- Rosenwald, Andreas (1)
- Rossi, Dominic M. (1)
- Roussel-Chomaz, P. (1)
- Rout, Prakash Chandra (1)
- Roy, S. (1)
- Röder, Marko (1)
- Saez, del Rio (1)
- Saha Sarkar, Maitreyee (1)
- Sakuta, S. (1)
- Salsac, M. (1)
- Sampson, J. (1)
- Sanchez, J. (1)
- Sanjari, Mohammad Shahab (1)
- Sarriguren, P. (1)
- Sauerwein, Anne (1)
- Savran, Deniz (1)
- Scheidenberger, Christoph (1)
- Scheit, Heiko (1)
- Schmid, Mirko von (1)
- Schmidt, Stefan (1)
- Schmitt, C. (1)
- Schnorrenberger, Linda (1)
- Schrock, P. (1)
- Schwengner, R. (1)
- Schwänen, Carsten (1)
- Seddon, D. (1)
- Sherrill, B. (1)
- Shrivastava, A. (1)
- Sidorchuk, S. (1)
- Siebert, Reiner (1)
- Silva, Joel (1)
- Simon, Haik (1)
- Simpson, E. (1)
- Singh, P. (1)
- Slobodan, D. (1)
- Sohler, D. (1)
- Sonnabend, Kerstin (1)
- Spieker, Mark-Christoph (1)
- Stach, D. (1)
- Stan, E. (1)
- Stanoiu, M. (1)
- Stein, Harald (1)
- Stepantsov, S. (1)
- Stevenson, P. (1)
- Streicher, Branislav (1)
- Strieder, F. (1)
- Stuhl, László (1)
- Suda, T. (1)
- Szczepanowski, Monika (1)
- Söderström, P. (1)
- Sümmerer, Klaus (1)
- Taieb, Julien (1)
- Takechi, M. (1)
- Tanihata, I. (1)
- Taylor, J. (1)
- Tengblad, Olof (1)
- Ter-Akopian, G. (1)
- Terashima, S. (1)
- Teubig, P. (1)
- Thies, Ronja (1)
- Thoennessen, M. (1)
- Thomas, T. (1)
- Thornhill, J. (1)
- Thungstrom, G. (1)
- Timar, J. (1)
- Togano, Yasuhiro (1)
- Tomohiro, U. (1)
- Tornyi, T. (1)
- Tostevin, J. (1)
- Townsley, C. (1)
- Trautmann, Heiko (1)
- Trautmann, Wolfgang (1)
- Trivedi, T. (1)
- Trümper, Lorenz (1)
- Typel, Stefan (1)
- Uberseder, E. (1)
- Udias, J. (1)
- Uesaka, T. (1)
- Uvarov, L. (1)
- Vajta, Z. (1)
- Velho, Paulo (1)
- Vikhrov, V. (1)
- Volknandt, Meiko (1)
- Volkov, Vasily (1)
- Wagner, A. (1)
- Wamers, Felix (1)
- Weick, Helmut (1)
- Weigand, Mario (1)
- Wells, D. (1)
- Wessendorf, Swen (1)
- Westerberg, L. (1)
- Wieland, Oliver (1)
- Wiescher, Michael (1)
- Willscher, Edith (1)
- Wimmer, Christine (1)
- Wimmer, K. (1)
- Winfield, John S. (1)
- Winkel, M. (1)
- Woods, Philip John (1)
- Wyss, R. (1)
- Yakorev, Dmitry (1)
- Yavor, M. (1)
- Zamora Cardona, Juan Carlos (1)
- Zartova, I. (1)
- Zerguerras, T. (1)
- Zgura, M. (1)
- Zhdanov, A. (1)
- Zhukov, Mikhail V. (1)
- Zieblinski, M. (1)
- Zilges, Andreas (1)
- Zuber, Kai (1)
Document Type
- Article (2)
Language
- English (2)
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Keywords
- B cell malignancies (1)
- Gene regulation (1)
- Machine learning (1)
- Molecular subtypes (1)
- Tumor heterogeneity (1)
Reifarth, René ; Altstadt, Sebastian ; Göbel, Kathrin ; Heftrich, Tanja ; Heil, Michael ; Koloczek, Alexander ; Langer, Christoph ; Plag, Ralf ; Pohl, M. ; Sonnabend, Kerstin ; Weigand, Mario ; Adachi, T. ; Aksouh, Farouk ; Al-Khalili, J. ; AlGarawi, M. ; AlGhamdi, S. ; Alkhazov, G. ; Alkhomashi, N. ; Alvarez-Pol, Héctor ; Alvarez-Rodriguez, R. ; Andreev, V. ; Andrei, B. ; Atar, Leyla ; Aumann, Thomas ; Avdeichikov, Vladimir ; Bacri, C. ; Bagchi, S. ; Barbieri, Carlo ; Beceiro, Saul ; Beck, C. ; Beinrucker, Clemens ; Belier, Gilbert ; Bemmerer, Daniel ; Bendel, M. ; Benlliure Anaya, Jose Fernando ; Benzoni, G. ; Berjillos, R. ; Bertini, D. ; Bertulani, Carlos A. ; Bishop, S. ; Blasi, N. ; Bloch, T. ; Blumenfeld, Y. ; Bonaccorso, A. ; Boretzky, Konstanze ; Botvina, Alexander ; Boudard, A. ; Boutachkov, P. ; Boztosun, I. ; Bracco, A. ; Brambilla, S. ; Monago, J.Briz ; Caamano, Manuel ; Caesar, Christoph ; Camera, F. ; Casarejos Ruiz, Enrique ; Catford, Wilton N. ; Cederkäll, Joakim ; Cederwall, B. ; Chartier, Marielle ; Chatillon, Audrey ; Cherciu, M. ; Chulkov, Leonid V. ; Coleman-Smith, P. ; Cortina Gil, Dolores ; Crespi, F. ; Crespo, Raquel ; Cresswell, J. ; Csatlós, Margit ; Déchery, F. ; Davids, B. ; Davinson, Thomas ; Derya, Vera ; Detistov, P. ; Díaz Fernández, Paloma ; DiJulio, D. ; Dmitry, S. ; Doré, D. ; Dueñas, J. ; Dupont, Emmeric ; Egelhof, Peter ; Egorova, I. ; Elekes, Zoltán ; Enders, Joachim ; Endres, Janis ; Ershov, S. ; Ershova, Olga ; Fernández Domínguez, Beatriz ; Fetisov, A. ; Fiori, Enrico ; Fomichev, A. ; Fonseca, M. ; Fraile, L. ; Freer, Martin ; Friese, Jürgen ; Garcia Borge, Maria José ; Galaviz Redondo, Daniel ; Gannon, S. ; Garg, U. ; Gašparić, Igor ; Gasques, L. ; Gastineau, B. ; Geissel, Hans ; Gernhäuser, Roman ; Ghosh, T. ; Gilbert, M. ; Glorius, Jan ; Golubev, Pavel ; Gorshkov, Alexander ; Gourishetty, A. ; Grigorenko, Leonid V. ; Gulyas, J. ; Haiduc, Maria ; Hammache, F. ; Harakeh, Muhsin N. ; Hass, M. ; Heine, Marcel ; Hennig, Andreas ; Henriques, Ana ; Herzberg, Rolf-Dietmar ; Holl, Matthias ; Ignatov, Alexander ; Ignatyuk, A. ; Ilieva, Stoyanka ; Ivanov, Marian ; Iwasa, N. ; Jakobsson, B. ; Johansson, Håkan T. ; Jonson, Björn ; Joshi, P. ; Junghans, Arnd Rudolf ; Jurado Apruzzese, Beatriz ; Körner, G. ; Kalantar, N. ; Kanungo, Rituparna ; Kelic-Heil, Aleksandra ; Kezzar, K. ; Khan, E. ; Khanzadeev, Alexei ; Kiselev, Oleg A. ; Kogimtzis, M. ; Körper, D. ; Kräckmann, S. ; Kröll, Thorsten ; Krücken, Reiner ; Krasznahorkay, Attila ; Kratz, Jens-Volker ; Kresan, Dmytro ; Krings, Thomas ; Krumbholz, A. ; Krupko, S. ; Kulessa, Reinhard ; Kumar, Shyam ; Kurz, Nikolaus ; Kuzmin, E. ; Labiche, Marc ; Langanke, Karlheinz ; Lazarus, I. ; Bleis, T.Le ; Lederer, Claudia ; Lemasson, A. ; Lemmon, Roy Crawford ; Liberati, V. ; Litvinov, Yuri A. ; Löher, Bastian ; Herraiz, J.Lopez ; Münzenberg, G. ; Machado, Jorge ; Maev, E. ; Mahata, Kripamay ; Mancusi, D. ; Marganiec, Justyna ; Perez, M.Martinez ; Marusov, V. ; Mengoni, D. ; Million, B. ; Morcelle, V. ; Moreno, O. ; Movsesyan, Alina ; Nácher González, Enrique ; Najafi, Mohammad Ali ; Nakamura, T. ; Naqvi, F. ; Nikolski, E. ; Nilsson, Thomas ; Nociforo, Chiara ; Nolan, P. ; Novatsky, B. ; Nyman, Göran Hugo ; Ornelas, A. ; Palit, R. ; Pandit, S. ; Panin, Valerii ; Paradela Dobarro, Carlos ; Parkar, V. ; Paschalis, Stefanos ; Pawłowski, P. ; Perea Martinez, Angel ; Pereira, J. ; Petrache, C. ; Petri, Marina ; Pickstone, Simon Glynn ; Pietralla, Norbert ; Pietri, Stephane ; Pivovarov, Y. ; Potlog, P. ; Prokofiev, Andrey ; Rastrepina, G. ; Rauscher, Thomas ; Ribeiro Jimenez, Guillermo ; Ricciardi, Maria Valentina ; Richter, Achim ; Rigollet, Catherine ; Riisager, Karsten ; Rios, A. ; Ritter, C. ; Rodríguez Frutos, Tomás Raúl ; Rodríguez Vignote, Javier ; Röder, Marko ; Romig, Christopher ; Rossi, Dominic M. ; Roussel-Chomaz, P. ; Rout, Prakash Chandra ; Roy, S. ; Söderström, P. ; Saha Sarkar, Maitreyee ; Sakuta, S. ; Salsac, M. ; Sampson, J. ; Sanchez, J. ; Saez, del Rio ; Rosado, J.Sanchez ; Sanjari, Mohammad Shahab ; Sarriguren, P. ; Sauerwein, Anne ; Savran, Deniz ; Scheidenberger, Christoph ; Scheit, Heiko ; Schmidt, Stefan ; Schmitt, C. ; Schnorrenberger, Linda ; Schrock, P. ; Schwengner, R. ; Seddon, D. ; Sherrill, B. ; Shrivastava, A. ; Sidorchuk, S. ; Silva, Joel ; Simon, Haik ; Simpson, E. ; Singh, P. ; Slobodan, D. ; Sohler, D. ; Spieker, Mark-Christoph ; Stach, D. ; Stan, E. ; Stanoiu, M. ; Stepantsov, S. ; Stevenson, P. ; Strieder, F. ; Stuhl, László ; Suda, T. ; Sümmerer, Klaus ; Streicher, Branislav ; Taieb, Julien ; Takechi, M. ; Tanihata, I. ; Taylor, J. ; Tengblad, Olof ; Ter-Akopian, G. ; Terashima, S. ; Teubig, P. ; Thies, Ronja ; Thoennessen, M. ; Thomas, T. ; Thornhill, J. ; Thungstrom, G. ; Timar, J. ; Togano, Yasuhiro ; Tomohiro, U. ; Tornyi, T. ; Tostevin, J. ; Townsley, C. ; Trautmann, Wolfgang ; Trivedi, T. ; Typel, Stefan ; Uberseder, E. ; Udias, J. ; Uesaka, T. ; Uvarov, L. ; Vajta, Z. ; Velho, Paulo ; Vikhrov, V. ; Volknandt, Meiko ; Volkov, Vasily ; Neumann-Cosel, Peter von ; Schmid, Mirko von ; Wagner, A. ; Wamers, Felix ; Weick, Helmut ; Wells, D. ; Westerberg, L. ; Wieland, Oliver ; Wiescher, Michael ; Wimmer, Christine ; Wimmer, K. ; Winfield, John S. ; Winkel, M. ; Woods, Philip John ; Wyss, R. ; Yakorev, Dmitry ; Yavor, M. ; Zamora Cardona, Juan Carlos ; Zartova, I. ; Zerguerras, T. ; Zgura, M. ; Zhdanov, A. ; Zhukov, Mikhail V. ; Zieblinski, M. ; Zilges, Andreas ; Zuber, Kai
The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process β-decay chains. These nuclei are attributed to the p and rp process.
For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections.
The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.
Löffler-Wirth, Henry ; Kreuz, Markus ; Hopp, Lydia ; Arakelyan, Arsen ; Haake, Andrea ; Cogliatti, Sergio B. ; Feller, Alfred Christian ; Hansmann, Martin-Leo ; Lenze, Dido ; Möller, Peter ; Müller-Hermelink, Hans Konrad ; Fortenbacher, Erik ; Willscher, Edith ; Ott, German ; Rosenwald, Andreas ; Pott, Christiane ; Schwänen, Carsten ; Trautmann, Heiko ; Wessendorf, Swen ; Stein, Harald ; Szczepanowski, Monika ; Trümper, Lorenz ; Hummel, Michael ; Klapper, Wolfram ; Siebert, Reiner ; Löffler, Markus ; Binder, Hans
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma.
Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical characteristics.
Results: We present a transcriptome map of B cell lymphomas that allows visual comparison between the SOM portraits of different lymphoma strata and individual cases. It decomposes into one dozen modules of co-expressed genes related to different functional categories, to genetic defects and to the pathogenesis of lymphomas. On a molecular level, this disease rather forms a continuum of expression states than clearly separated phenotypes. We introduced the concept of combinatorial pattern types (PATs) that stratifies the lymphomas into nine PAT groups and, on a coarser level, into five prominent cancer hallmark types with proliferation, inflammation and stroma signatures. Inflammation signatures in combination with healthy B cell and tonsil characteristics associate with better overall survival rates, while proliferation in combination with inflammation and plasma cell characteristics worsens it. A phenotypic similarity tree is presented that reveals possible progression paths along the transcriptional dimensions. Our analysis provided a novel look on the transition range between FL and DLBCL, on DLBCL with poor prognosis showing expression patterns resembling that of Burkitt’s lymphoma and particularly on "double-hit" MYC and BCL2 transformed lymphomas.
Conclusions: The transcriptome map provides a tool that aggregates, refines and visualizes the data collected in the MMML study and interprets them in the light of previous knowledge to provide orientation and support in current and future studies on lymphomas and on other cancer entities.
- 1 to 2