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Lecanora leprosa and L. sulphurescens are two commonly misidentified pantropical lichens. A detailed circumscription is presented to help overcome such difficulties. Both species contain a chemosyndrome of chlorodepsidones based on gangaleoidin. The new depsidone chlorolecideoidin (methyl 2,4,9-trichloro-3,8-dihydroxy-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]-dioxepin- 7-carboxylate) has been shown to be a minor component of both species.