Refine
Year of publication
Document Type
- Article (68)
- Preprint (2)
- Part of Periodical (1)
Has Fulltext
- yes (71)
Is part of the Bibliography
- no (71)
Keywords
- LHC (7)
- ALICE (3)
- ALICE experiment (3)
- pp collisions (3)
- Beauty production (2)
- Biodiversität (2)
- Single electrons (2)
- biodiversity (2)
- canopy fauna (2)
- 18-Hydroxycorticosteron (1)
- 18-OH corticosterone (1)
- 900 GeV (1)
- Abies alba (1)
- Aphidophagen (1)
- Arten-Umwelt-Beziehung (1)
- Bark beetle (1)
- Baumkronen Fauna (1)
- Bestandsstruktur (1)
- Biodiversity (1)
- Brain metastasis (1)
- Brain tumors (1)
- Brandenburg (1)
- CD74 (1)
- COVID-19 (1)
- CVID (1)
- Cancer (1)
- Central Europe (1)
- Children and adolescents (1)
- Chocó rainforest (1)
- Chorion (1)
- Climate Change (1)
- Climate-change ecology (1)
- Coccinellidae (1)
- Cognitive impairment (1)
- Community ecology (1)
- Comparison with QCD (1)
- Conservation biology (1)
- Diagnostic error (1)
- Ectomycorrhizal fungi (1)
- Ecuador (1)
- Enzyme activity (1)
- European Society for Immunodeficiencies (ESID) (1)
- Femtoscopy (1)
- Forest disturbance (1)
- General practice (1)
- German PID-NET registry (1)
- HBT (1)
- HLA class II (1)
- HLA peptidome (1)
- Habitattradition (1)
- Hadron production (1)
- Heavy Ions (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Herbivore (1)
- Heteroptera (1)
- IgG substitution therapy (1)
- Inclusive spectra (1)
- Intensity interferometry (1)
- Jets (1)
- Klimawandel (1)
- Kronenfauna (1)
- LTP (1)
- Landschnecken (1)
- Leukemia (1)
- Mid-rapidity (1)
- Mitteleuropa (1)
- Multi-strange baryons (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NOAEC (1)
- Nebennierenrinden-Adenom (1)
- Nebennierenrinden-Hyperplasie (1)
- Neuroptera (1)
- Nuclear modification factor (1)
- PID prevalence (1)
- PYTHIA (1)
- Parkinson disease (1)
- Patient reported outcomes (1)
- Patient safety (1)
- Pb–Pb (1)
- Picea abies (1)
- Primary health care (1)
- Proton–proton (1)
- Radiation Oncology (1)
- Radiotherapy (1)
- Real-time polymerase chain reaction (PCR) tests (1)
- Regret (1)
- SARS-CoV-2 testing (1)
- Salvage logging (1)
- Sarcomas (1)
- Single muons (1)
- Social participation (1)
- Soil carbon and nitrogen cycle (1)
- Soil fungi (1)
- Soil organic matter decomposition (1)
- Tetrahydro-Aldosteron (1)
- Totholz (1)
- Totholzangebot (1)
- Transverse momentum (1)
- Tumor infiltrating lymphocytes (1)
- Uncertainty (1)
- Urwaldreliktarten (1)
- Windthrow (1)
- aboveground biomass (1)
- adjustment (1)
- adrenal adenomas (1)
- aging (1)
- amyloid precursor protein (1)
- aphidophagous insects (1)
- autoantibodies (1)
- chronosequence (1)
- cold tolerance (1)
- compaction (1)
- dead wood (1)
- deadwood experiments (1)
- dispersal (1)
- dopamine (1)
- dynamic temperature (1)
- forest management (1)
- forest structure (1)
- freeze avoidance (1)
- fungal traits (1)
- genetic diversity (1)
- global biomes (1)
- habitat filter (1)
- habitat tradition (1)
- hippocampus (1)
- homogeneity (1)
- iron deficiency (1)
- latitudinal gradient (1)
- low-dose effects (1)
- mean fruit body size (1)
- mineralization (1)
- mitochondria (1)
- multiple stressors (1)
- near-natural (1)
- osteoblast (1)
- osteoclasts (1)
- patient blood management (1)
- preoperative anaemia management (1)
- presynaptic active zone (1)
- primary aldosteronism (1)
- primary biliary cholangitis (1)
- primary immunodeficiency (PID) (1)
- primeval forest (1)
- primärer Hyperaldosteronismus (1)
- reassembly (1)
- registry for primary immunodeficiency (1)
- resilience (1)
- resistance (1)
- rheumatoid arthritis (1)
- saprobic and ectomycorrhizal basidiomycetes (1)
- second line therapy (1)
- solar surface irradiance (1)
- species-environment relationships (1)
- spectra (1)
- tetrahydroaldosterone (1)
- treatment response (1)
- trees (1)
- ursodeoxycholic acid (1)
- wax layer (1)
- winter survival (1)
- wood-inhabiting fungi (1)
- xylobiontic beetles (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (29)
- Informatik (20)
- Frankfurt Institute for Advanced Studies (FIAS) (19)
- Medizin (18)
- Biowissenschaften (9)
- Institut für Ökologie, Evolution und Diversität (4)
- Geowissenschaften (3)
- Senckenbergische Naturforschende Gesellschaft (3)
- Biodiversität und Klima Forschungszentrum (BiK-F) (2)
- Exzellenzcluster Makromolekulare Komplexe (2)
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
A measurement of the transverse momentum spectra of jets in Pb-Pb collisions at sNN−−−√=2.76 TeV is reported. Jets are reconstructed from charged particles using the anti-kT jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudo-rapidity |η|<0.5. The transverse momentum pT of charged particles is measured down to 0.15 GeV/c which gives access to the low pT fragments of the jet. Jets found in heavy-ion collisions are corrected event-by-event for average background density and on an inclusive basis (via unfolding) for residual background fluctuations and detector effects. A strong suppression of jet production in central events with respect to peripheral events is observed. The suppression is found to be similar to the suppression of charged hadrons, which suggests that substantial energy is radiated at angles larger than the jet resolution parameter R=0.3 considered in the analysis. The fragmentation bias introduced by selecting jets with a high pT leading particle, which rejects jets with a soft fragmentation pattern, has a similar effect on the jet yield for central and peripheral events. The ratio of jet spectra with R=0.2 and R=0.3 is found to be similar in Pb-Pb and simulated PYTHIA pp events, indicating no strong broadening of the radial jet structure in the reconstructed jets with R<0.3.
Transverse momentum spectra of π±, K± and p(p¯) up to pT = 20 GeV/c at mid-rapidity in pp, peripheral (60–80%) and central (0–5%) Pb–Pb collisions at √sNN = 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT ≈ 3 GeV/c in central Pb–Pb collisions. Below the peak, pT < 3 GeV/c, both ratios are in good agreement with hydrodynamical calculations, suggesting that the peak itself is dominantly the result of radial flow rather than anomalous hadronization processes. For pT > 10 GeV/c particle ratios in pp and Pb–Pb collisions are in agreement and the nuclear modification factors for π±, K± and p(p¯) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets.
The project focuses on the efficiency of combined technologies to reduce the release of micropollutants and bacteria into surface waters via sewage treatment plants of different size and via stormwater overflow basins of different types. As a model river in a highly populated catchment area, the river Schussen and, as a control, the river Argen, two tributaries of Lake Constance, Southern Germany, are under investigation in this project. The efficiency of the different cleaning technologies is monitored by a wide range of exposure and effect analyses including chemical and microbiological techniques as well as effect studies ranging from molecules to communities.
Background: Experienced and anticipated regret influence physicians’ decision-making. In medicine, diagnostic decisions and diagnostic errors can have a severe impact on both patients and physicians. Little empirical research exists on regret experienced by physicians when they make diagnostic decisions in primary care that later prove inappropriate or incorrect. The aim of this study was to explore the experience of regret following diagnostic decisions in primary care.
Methods: In this qualitative study, we used an online questionnaire on a sample of German primary care physicians. We asked participants to report on cases in which the final diagnosis differed from their original opinion, and in which treatment was at the very least delayed, possibly resulting in harm to the patient. We asked about original and final diagnoses, illness trajectories, and the reactions of other physicians, patients and relatives. We used thematic analysis to assess the data, supported by MAXQDA 11 and Microsoft Excel 2016.
Results: 29 GPs described one case each (14 female/15 male patients, aged 1.5–80 years, response rate < 1%). In 26 of 29 cases, the final diagnosis was more serious than the original diagnosis. In two cases, the diagnoses were equally serious, and in one case less serious. Clinical trajectories and the reactions of patients and relatives differed widely. Although only one third of cases involved preventable harm to patients, the vast majority (27 of 29) of physicians expressed deep feelings of regret.
Conclusion: Even if harm to patients is unavoidable, regret following diagnostic decisions can be devastating for clinicians, making them ‘second victims’. Procedures and tools are needed to analyse cases involving undesirable diagnostic events, so that ‘true’ diagnostic errors, in which harm could have been prevented, can be distinguished from others. Further studies should also explore how physicians can be supported in dealing with such events in order to prevent them from practicing defensive medicine.
Die Bewirtschaftung von Waldökosystemen unter Berücksichtigung der natürlichen Lebensgemeinschaften ist heute anerkanntes Ziel der Mehrzahl mitteleuropäischer Forstbetriebe. Dies zeigen auch die verschiedenen forstlichen Zertifizierungssysteme (PEFC, FSC, Naturland). Dass es sich dabei immer um einen Kompromiss zwischen Nutz- und Schutzfunktionen handeln muss, beruht auf der Tatsache, dass einerseits der Rohstoff Holz auf Grund seiner günstigen Ökobilanz zu den umweltfreundlichsten gehört, andererseits entnommenes Holz im Wald immer auch einen Verlust an Nährstoff und Lebensraum darstellt (SPEIGHT 1989, GROVE 2002b). Um so wichtiger ist eine nach Artengruppen und Prozessen differenzierte Analyse zur Bedeutung der verschiedenen Totholzarten und Mengen. Erst diese kann dann in einem optimierten Kompromiss münden. Dass Totholz eine überragende Rolle im Naturnähecharakter von Wäldern spielt ist inzwischen unbestritten. Es hat sich auch gezeigt dass für Strukturspezialisten bestimmte Mengen (BÜTLER ET AL. 2004, MÜLLER 2005a) und Vernetzungen (SCHIEGG 2000), für andere wieder ein ausreichendes Angebot an seltenen Totholzhabitaten wie Mulmhöhlen (RANIUS 2002) notwendig sind. Tatsächlich dominieren im Gegensatz zu Skandinavien in den heutigen mitteleuropäischen Wäldern häufig nicht mehr die Baumarten der natürlichen Waldgesellschaften. Diese standortheimischen Arten wurden durch raschwüchsige Koniferen (meist Fichte, Kiefer oder Lärche, seltener Douglasie) ersetzt (GOßNER 2004). Für spezialisierte Insektenarten wie xylobionte Käfer, zeigt sich dabei, dass letztlich nur weit verbreitete Generalisten hier den Wirtspflanzen gefolgt sind (GOßNER 2004, MÜLLER 2005b). Spezialisten der Nadelbäume, die sich häufig in den Roten Listen wiederfinden, bedürfen aber einer Kombination aus Standortsparametern und Nadelbaumart, an die sie sich im Laufe der Evolution angepasst haben.
Urwald relict species – Saproxylic beetles indicating structural qualities and habitat tradition
(2005)
On the basis of the list of saproxylic beetles of Germany, the authors present a definition and list of “Urwald relict species”, comprising 115 beetles that are considered to be associated with primeval forest (“Urwald”) structures and features. We use the term “habitat tradition” to describe a continuity in supply of old growth dead wood and forest structures. The selection of species is made on behalf of the following criteria: relict records in Central Europe; attachment to continuity of deadwood resources and habitat tradition; continuity of old growth stand features like tree and deadwood maturity and di-versity; absence from cultivated Central European forest.
To understand the rapid rate of change in global biodiversity, it is necessary to analyse the present condition of ecosystems and to elucidate relationships of species to their environment. The BIOKLIM Project (Biodiversity and Climate Change Project) is intended to close this gap in our knowledge of montane and high montane forests of Central European low mountain ranges, one of the most threatened mixed montane systems worldwide. The Bavarian Forest National Park is characterised by its altitude range of ca. 800 m and a strongly developed gradient of forest structure. Relicts of old growth forests (areas of former local nature reserves) and dead stands, mostly killed by bark beetles, are accompanied by widely varying levels of woody debris and light. The gradients comprise a wide range of abiotic and forest structure factors, making the study area well suited for a multidisciplinary investigation of biodiversity. Unconstrained ordination (CA) of six taxa (vascular plants, wood inhabiting fungi, birds, carabids, spiders and molluscs) indicate the altitudinal gradient to be the main driver for distribution patterns of species assemblages. Objectives, structure, study design and data sampling of the BIOKLIM Project are described in detail. We set up 293 sampling plots along four main straight transects following the altitudinal gradient. All abiotic and stand structure data regarded as relevant are available for each plot. Vascular plants, wood inhabiting fungi and birds were sampled or mapped on all 293 plots. For the other 22 investigated taxa we used subsamples pre-stratified according to the sampling methods. The necessity of dealing with spatial autocorrelation, arising from sampling along linear transects, is described. Finally, study approach of our biodiversity project is compared with others involving altitudinal gradients. Worldwide, only a few multidisciplinary biodiversity studies have been previously conducted on long altitudinal gradients. However, in most cases sampling techniques were similar to ours, which allows comparison of results between continents. Keywords: Climate Change, Biodiversity, species-environment relationships
Background and objectives: Preoperative anaemia is an independent risk factor for a higher morbidity and mortality, a longer hospitalization and increased perioperative transfusion rates. Managing preoperative anaemia is the first of three pillars of Patient Blood Management (PBM), a multidisciplinary concept to improve patient safety. While various studies provide medical information on (successful) anaemia treatment pathways, knowledge of organizational details of diagnosis and management of preoperative anaemia across Europe is scarce.
Materials and methods: To gain information on various aspects of preoperative anaemia management including organization, financing, diagnostics and treatment, we conducted a survey (74 questions) in ten hospitals from seven European nations within the PaBloE (Patient Blood Management in Europe) working group covering the year 2016.
Results: Organization and activity in the field of preoperative anaemia management were heterogeneous in the participating hospitals. Almost all hospitals had pathways for managing preoperative anaemia in place, however, only two nations had national guidelines. In six of the ten participating hospitals, preoperative anaemia management was organized by anaesthetists. Diagnostics and treatment focused on iron deficiency anaemia which, in most hospitals, was corrected with intravenous iron.
Conclusion: Implementation and approaches of preoperative anaemia management vary across Europe with a primary focus on treating iron deficiency anaemia. Findings of this survey motivated the hospitals involved to critically evaluate their practice and may also help other hospitals interested in PBM to develop action plans for diagnosis and management of preoperative anaemia.
Although it has been suggested that temperature increase may alter the toxic potential of environmental pollutants, few studies have investigated the potential risk of chemical stressors for wildlife under Global Climate Change (GCC) impact. We applied a bifactorial multigeneration study in order to test if GCC conditions alter the effects of low pesticide concentrations on life history and genetic diversity of the aquatic model organism Chironomus riparius. Experimental populations of the species were chronically exposed to a low concentration of the fungicide pyrimethanil (half of the no-observed-adverse-effect concentration: NOAEC/2) under two dynamic present-day temperature simulations (11.0–22.7°C; 14.0–25.2°C) and one future scenario (16.5–28.1°C). During the 140-day multigeneration study, survival, emergence, reproduction, population growth, and genetic diversity of C. riparius were analyzed. Our results reveal that high temperature and pyrimethanil act synergistically on the midge C. riparius. In simulated present-day scenarios, a NOAEC/2 of pyrimethanil as derived from a life-cycle toxicity test provoked only slight-to-moderate beneficial or adverse effects on C. riparius. In contrast, exposure to a NOAEC/2 concentration of pyrimethanil at a thermal situation likely for a summer under GCC conditions uncovered adverse effects on mortality and population growth rate. In addition, genetic diversity was considerably reduced by pyrimethanil in the future scenario, but only slightly under current climatic conditions. Our multigeneration study under near-natural (climatic) conditions indicates that not only the impact of climate change, but also low concentrations of pesticides may pose a reasonable risk for aquatic insects in future.