Refine
Year of publication
Document Type
- Preprint (898)
- Article (870)
- Contribution to a Periodical (8)
- Part of Periodical (4)
- Conference Proceeding (2)
- Working Paper (2)
- Report (1)
- Review (1)
Has Fulltext
- yes (1786)
Is part of the Bibliography
- no (1786)
Keywords
- Heavy Ion Experiments (21)
- Hadron-Hadron scattering (experiments) (12)
- Hadron-Hadron Scattering (11)
- e +-e − Experiments (11)
- BESIII (10)
- LHC (9)
- Branching fraction (7)
- Magnetic resonance imaging (7)
- Particle and Resonance Production (7)
- Heavy-ion collision (6)
- Heavy-ion collisions (5)
- Hepatocellular carcinoma (5)
- Quarkonium (5)
- Spectroscopy (5)
- ALICE experiment (4)
- COVID-19 (4)
- CT (4)
- Charm Physics (4)
- Charm physics (4)
- Collective Flow (4)
- Electroweak interaction (4)
- Jets (4)
- Lepton colliders (4)
- MRI (4)
- Quark-Gluon Plasma (4)
- ALICE (3)
- Artificial intelligence (3)
- Cancer (3)
- Charmed mesons (3)
- Diffraction (3)
- Elastic scattering (3)
- Exotics (3)
- Experimental nuclear physics (3)
- Experimental particle physics (3)
- Hadronic decays (3)
- Heavy Ions (3)
- Heavy Quark Production (3)
- Jets and Jet Substructure (3)
- Neutropenia (3)
- Particle and resonance production (3)
- Polarization (3)
- QCD (3)
- e+-e− Experiments (3)
- microwave ablation (3)
- new species (3)
- pp collisions (3)
- AML (2)
- Acute myeloid leukemia (2)
- Algorithms (2)
- Beam Energy Scan (2)
- Beauty production (2)
- Bipolar disorder (2)
- Blood (2)
- Bone density (2)
- Branching fractions (2)
- Chiral Magnetic Effect (2)
- Collectivity (2)
- Consensus (2)
- Correlation (2)
- DSM (2)
- Diagnostic imaging (2)
- Diagnostic markers (2)
- Drug therapy (2)
- Dynamic MRI (2)
- ESBL (2)
- Electroweak Interaction (2)
- Elliptic flow (2)
- Embryos (2)
- Flow cytometry (2)
- Guidelines (2)
- Intensive care units (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Leptonic, semileptonic & radiative decays (2)
- Machine learning (2)
- Microwave ablation (2)
- Multidetector computed tomography (2)
- Neoplasms (2)
- Nuclear reactions (2)
- Osteoporosis (2)
- Particle Correlations and Fluctuations (2)
- Particle correlations and fluctuations (2)
- Particle decays (2)
- Pb–Pb collisions (2)
- Positron emission tomography (2)
- Predictive markers (2)
- Prostate cancer (2)
- Psychiatric disorders (2)
- RHIC (2)
- Radiomics (2)
- SARS-CoV-2 (2)
- STAR (2)
- Shear viscosity (2)
- Single electrons (2)
- Spine (2)
- Suicide (2)
- Survival (2)
- Tomography (x-ray computed) (2)
- Transarterial chemoembolization (2)
- VRE (2)
- Vasculitis (2)
- breast cancer (2)
- computed tomography (2)
- global change (2)
- hepatocellular carcinoma (2)
- inflammation (2)
- liver (2)
- penile cancer (2)
- solitary bees (2)
- targeted therapy (2)
- taxonomy (2)
- 16 segment AHA model (1)
- 16S (1)
- 3years (1)
- 5 lipoxygenase (1)
- 900 GeV (1)
- ADHD (1)
- AKT (1)
- ALICE detector (1)
- ALL (1)
- Aachener Hügelland (1)
- Abdominal infections (1)
- Ablation Techniques (1)
- Accelerators & Beams (1)
- Accelerators & storage rings (1)
- Actin (1)
- Active middle ear implants (1)
- Activities of daily living (1)
- Acute calcolous cholecystitis (1)
- Adjustment of dosage at steady state (1)
- Adverse events (1)
- Afroarabiella (1)
- Age determination by skeleton (1)
- Age groups (1)
- Amino acid analysis (1)
- Amizon (1)
- Anemia (1)
- Angiography (1)
- Animal flight (1)
- Animal models (1)
- Animal personality (1)
- Anti-nuclei (1)
- Antibiotic (1)
- Antibiotic steward-ship (1)
- Antibiotics (1)
- Antifungal agents (1)
- Antiretroviral therapy (1)
- Aortic valve replacement (1)
- Apoidea (1)
- Aromatase Inhibitors (1)
- Artemisia tridentata (1)
- Aspergillosis (1)
- Atherosclerosis (1)
- Atomic & molecular beams (1)
- Atomic, Molecular & Optical (1)
- Atrial fibrillation (1)
- Auditory system (1)
- Automated Tube Potential Selection (1)
- Autoregressiver Prozess (1)
- Awareness campaign (1)
- B-slope (1)
- BESIII detector (1)
- Bacterial genes (1)
- Bayes-Verfahren (1)
- Bayesian inference (1)
- Beam energy scan (1)
- Beam loss (1)
- Behavioral reaction norms (1)
- Behavioral specialization (1)
- Behavioral syndromes (1)
- Behavioral type (1)
- Berci needle (1)
- Best practice (1)
- Bhabha (1)
- Biliary tree stones (1)
- Biodiversity (1)
- Biofluids (1)
- Biogeochemistry (1)
- Biologging (1)
- Biological (1)
- Biological heart valves (1)
- Bioprosthesis (1)
- Biopsy (1)
- Biosynthesis (1)
- Bird flight (1)
- Bloodstream infections (1)
- Bone conduction devices (1)
- Bone diseases, Metabolic (1)
- Bone marrow (1)
- Boosted Jets (1)
- Born cross section (1)
- Born cross section measurement (1)
- Borrelia burgdorferi (1)
- Breast cancer (1)
- Breast tumors (1)
- Business strategy in drug development (1)
- C1-INH (C1 inhibitor, C1-esterase inhibitor) (1)
- CAKUT (1)
- CD36 (1)
- CDI (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- COI (1)
- CP violation (1)
- CRISPR/Cas (1)
- CT dual-energy computed tomography (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CT-guidance (1)
- CT-guided interventions (1)
- Calcium (1)
- Calorimeter methods (1)
- Calorimeters (1)
- Cancer Staging (1)
- Cancer check up (1)
- Cancer detection (1)
- Cancer staging (1)
- Canonical suppression (1)
- Canopy height model (1)
- Carbon cycle (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac implantable electronic devices (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy (1)
- Cardiomyopathy (1)
- Cardiovascular diseases (1)
- Cardiovascular magnetic resonance (1)
- Carpenter moths (1)
- Catheter ablation (1)
- Cell binding (1)
- Cell staining (1)
- Central Asia (1)
- Centrality Class (1)
- Centrality Selection (1)
- Charge-transfer collisions (1)
- Charged-particle multiplicity (1)
- Charm quark spatial diffusion coefficient (1)
- Charmonia (1)
- Charmonium (1)
- Charmonium (-like) (1)
- Cheatgrass (1)
- Chemoembolization (1)
- Chemotherapy (1)
- Chickens (1)
- Children (1)
- Chiral magnetic effect (1)
- Cholecystectomy (1)
- Chondral Lesion (1)
- Chronic hepatitis C (1)
- Circadian (1)
- Circular accelerators (1)
- Closure (1)
- Coalescence (1)
- Cochlear implantation (1)
- Cognitive-motor interference (1)
- Cohort studies (1)
- Colchicum (1)
- Cold nuclear matter effects (1)
- Collective Flow, (1)
- Comparison with QCD (1)
- Complement system (1)
- Complex I (1)
- Computed tomography (1)
- Computed tomography imaging (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computed tomography, X-ray (1)
- Computer-aided drug design (1)
- Cone-beam computed tomography (1)
- Congenital (1)
- Congenital anomalies (1)
- Consensus document (1)
- Consensus statement (1)
- Conservation biology (1)
- Contrast agent (1)
- Cossidae (1)
- Critical point (1)
- Cross section (1)
- Cryoballoon (1)
- Cucujoidea (1)
- Curculionoidea (1)
- Cycad pollination (1)
- Cystic fibrosis (1)
- D meson (1)
- DME (1)
- DNA sequence analysis (1)
- DNA-barcoding (1)
- DST (1)
- Dark photon (1)
- Dark sector (1)
- Data Standard (1)
- Data sharing (1)
- Death rates (1)
- Dermis (1)
- Detector design and construction technologies and materials (1)
- Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc) (1)
- Deuteron (1)
- Deuteron production (1)
- Di-hadron correlations (1)
- Diagnosis (1)
- Diagnostic accuracy (1)
- Diagnostic differentiation (1)
- Diffusion magnetic resonance imaging (1)
- Digital (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital mammography (1)
- Dilated cardiomyopathy (1)
- Direct reactions (1)
- Dissociative seizures (1)
- Drug susceptibility testing (1)
- Dual task walking (1)
- Dual-Source CT (1)
- Dual-energy computed tomography (1)
- Dumon stents (1)
- Early goal-directed therapy (1)
- Ecosystem ecology (1)
- Edema (1)
- Effective form factor (1)
- Electric stimulation (1)
- Electromagnetic form factor (1)
- Electromagnetic form factors (1)
- Electron-pion identification (1)
- Electronic transitions (1)
- Endoscopic ultrasound (1)
- Endovascular aortic repair (1)
- Enterobacteriaceae (1)
- Environmental impact (1)
- Enzymatic DNA Methylation (1)
- Enzymatic Methylation (1)
- Equity (1)
- Estrogen Receptor Modulators (1)
- Evolutionary biology (1)
- Evolutionary genetics (1)
- Exercise training (1)
- Extended donor criteria (1)
- Exudates and transudates (1)
- FAV00A (1)
- FF-ATP synthase dimer (1)
- FOS: Physical sciences (1)
- Facial nerve (1)
- Feasibility studies (1)
- Feathers (1)
- Femtoscopy (1)
- Fetal heart (1)
- Fevers (1)
- Fibre/foam sandwich radiator (1)
- Fibroblast growth factor (1)
- First experience with patients (1)
- Fistula (1)
- Flavor changing neutral currents (1)
- Flavor symmetries (1)
- Flavour Physics (1)
- Florida (1)
- Flow (1)
- Fmoc solid phase peptide synthesis (1)
- Follow-up (1)
- Forest ecology (1)
- Forestiera segregata (1)
- Forestry (1)
- Form factors (1)
- Forward physics (1)
- G-protein-coupled receptors (1)
- GWAS (1)
- Gadobutrol (1)
- Gadopentate dimeglumine (1)
- Gait analysis (1)
- Gallbladder percutaneous drainage (1)
- Gastrointestinal (1)
- Gene expression (1)
- Genetics (1)
- Genome editing (1)
- Geochemistry (1)
- Goserelin (1)
- Gram negative bacteria (1)
- Green fluorescent protein (1)
- Groin pain (1)
- Groomed jet radius (1)
- Großbritannien (1)
- Gαq/11 (1)
- HBT (1)
- HCC (1)
- HIV (1)
- HadCM3 (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hadronization (1)
- Hard Scattering (1)
- Health policy (1)
- Heart (1)
- Heart defects (1)
- Heart failure (1)
- Heart transplantation (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ion collisions (1)
- Heavy ions (1)
- Heavy-Ion Collision (1)
- Heavy-flavor decay electron (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion (1)
- Hematologic malignancies (1)
- Hematopoietic stem cell transplantation (1)
- Hereditary angioedema (1)
- Herniated disk (1)
- Heteroptera (1)
- High Energy Physics - Experiment (hep-ex) (1)
- High-energy neutron detection (1)
- Higher moments (1)
- Horses (1)
- Hospitals (1)
- Human behaviour (1)
- Hyperons (1)
- IFN-β (1)
- IHMCIF (1)
- ILUVIEN (1)
- Iberian endemic species (1)
- Image processing (1)
- Image processing (computer-assisted) (1)
- Immunogenetics (1)
- Immunology (1)
- Implantable cardioverter-defibrillator (1)
- In-TIPS thrombosis (1)
- Inclusive branching fraction (1)
- Inclusive spectra (1)
- Induction chemotherapy (1)
- Infection (1)
- Influenza (1)
- Inguinal hernia (1)
- Inguinal pain (1)
- Initial state radiation (1)
- Integrative Modeling (1)
- Intensity interferometry (1)
- Intensive care unit (1)
- Interference fragmentation function (1)
- Interventional oncological treatment (1)
- Intervertebral disc displacement (1)
- Intra-abdominal infection (1)
- Invariant Mass Distribution (1)
- Invasive candidiasis (1)
- Inverted DNA Repeats (1)
- Invisible decays (1)
- Ionisation energy loss (1)
- J/ψ suppression (1)
- Jet Physics (1)
- Jet Substructure (1)
- Jet substructure (1)
- Jurkat (1)
- K0S (1)
- KLK5 (1)
- Kollision (1)
- Korrelation (1)
- Kupffer cells (1)
- LASS (1)
- LNS (1)
- LPJ-GUESS (1)
- Lactic acidosis (1)
- Laparostomy (1)
- Laser interstitial thermal therapy (1)
- Laser navigation system (1)
- Lateral recess stenosis (1)
- Lepidoptera (1)
- Lifestyle (1)
- Lipidol (1)
- Lipiodol (1)
- Liver (1)
- Liver cancer (1)
- Liver cirrhosis (1)
- Local control (1)
- Low & intermediate-energy accelerators (1)
- Low back pain (1)
- Lumbar spinal canal stenosis (1)
- Lumbar spine (1)
- Lung neoplasms (1)
- Lymphangioleiomyomatosis (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MEDIC (1)
- MLL (1)
- MMP9 (1)
- MRP4 (1)
- MRSA (1)
- Macrophages (1)
- Magnetic resonance (1)
- Marine chemistry (1)
- Mastoiditis (1)
- Material budget (1)
- Medical Oncology (1)
- Medical Physics: Diagnostic (1)
- Medical research (1)
- Mena/VASP (1)
- Mesh (1)
- Metastasis (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Mid-rapidity (1)
- Minimal detectable change (1)
- Minimum Bias (1)
- Miocene cooling (1)
- Miridae (1)
- Mirinae (1)
- Mitochondrial disorder (1)
- Mitomycin C (1)
- Mixed hearing loss (1)
- Molecular neuroscience (1)
- Monitoring (1)
- Monte Carlo (1)
- Mortality (1)
- Mouse models (1)
- Multi-Parton Interactions (1)
- Multi-neutron detection (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Multidetector Computed Tomography (1)
- Multidisciplinary management (1)
- Multidrug-resistant organisms (1)
- Multimodal imaging (1)
- Multiparametric MRI (1)
- Multiple parton interactions (1)
- Multivariate analysis (1)
- Mutation databases (1)
- Mycobacteria (1)
- Mycobacterium avium complex (1)
- Mycoses (1)
- Myocardial perfusion (1)
- Myocardial segmentation (1)
- Myocarditis (1)
- NIRS (1)
- NSF (1)
- NTM (1)
- Necrotic area (1)
- Neolithic (1)
- Neonatal (1)
- Net-charge correlations (1)
- Net-charge fluctuations (1)
- Neural network (1)
- Neutrinos (1)
- Niederrheinische Bucht (1)
- Non-trauma (1)
- Non-tuberculous mycobacteria (1)
- Noncoding RNA (1)
- Nonflow (1)
- Noninferiority (1)
- Nonpenetrating (1)
- Nontuberculous mycobacteria (1)
- Nuclear astrophysics (1)
- Nuclear modification factor (1)
- Nuclear physics of explosive environments (1)
- Nuclear structure & decays (1)
- Nucleon induced nuclear reactions (1)
- Nutrition (1)
- Nymphs (1)
- Older adults (1)
- Oncology (1)
- Open Access (1)
- Open abdomen (1)
- Opportunistic infections (1)
- Organ allocation (1)
- Osteoporotic fractures (1)
- Oswestry Disability Score (1)
- P2X7 receptor (1)
- PDB-Dev (1)
- PDBx/mmCIF (1)
- PDCD4 (1)
- PGE2 (1)
- PSA screening (1)
- PSA-Screening (1)
- PYTHIA (1)
- Pacemaker (1)
- Palaeoceanography (1)
- Palaeoclimate (1)
- Pancreas transplantation (1)
- Pancreatitis (1)
- Pandemic (1)
- Parainfluenza (1)
- Particle phenomena (1)
- Particle production (1)
- Patellofemoral Joint (1)
- Patient safety (1)
- Pb–Pb (1)
- Pediatric (1)
- Pediatric infections (1)
- Pediatrics (1)
- Percutaneous (1)
- Peritonitis (1)
- Personalized medicine (1)
- Phantom study (1)
- Phantoms (imaging) (1)
- Phospholipids (1)
- Photon counting (1)
- Physical activity (1)
- Physics (1)
- Plastic scintillator array (1)
- Pneumonia (1)
- Population-based screening (1)
- Portal (1)
- Poverty (1)
- Preclinical research (1)
- Predictability (1)
- Prediction (1)
- Prevention (1)
- Preventive medicine (1)
- Production Cross Section (1)
- Prognosis (1)
- Prognostic markers (1)
- Properties of Hadrons (1)
- Prostata-specific antigen (1)
- Prostataspezifisches Antigen (1)
- Protease inhibitor therapy (1)
- Proton (1)
- Proton-proton collisions (1)
- Proton–proton (1)
- Proton–proton collisions (1)
- Prävention (1)
- Pseudo HE-images (1)
- Psychiatry (1)
- Quantitative Imaging (1)
- Quantitative features (1)
- Quantum chromodynamics (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Quark–gluon plasma (1)
- RNA polymerase (1)
- RNA, long noncoding (1)
- RNA-DNA-Hybridization (1)
- Radiative capture (1)
- Radiative decay (1)
- Radiofrequency (1)
- Radiology (1)
- Raman spectroscopy (1)
- Rapidity Range (1)
- Rare decays (1)
- Re-exploration (1)
- Reactions with relativistic radioactive beams (1)
- Reassociation Kinetics (1)
- Recall rate (1)
- Regulatory networks (1)
- Rehabilitation (1)
- Rehospitalization (1)
- Reintervention (1)
- Rejection (1)
- Relativistic heavy ion physics (1)
- Relativistic heavy-ion collisions (1)
- Renal lesions (1)
- Resolution Parameter (1)
- Resonances (1)
- Respiratory infections (1)
- Respiratory syncytial virus (1)
- Response (1)
- Retro-IDEAL (1)
- Retrospective studies (1)
- Retrospective study (1)
- SLC20A1 (1)
- STIR (1)
- SVR (1)
- Safety (1)
- Seasonal variation (1)
- Semi-leptonic decays (1)
- Senecio inaequidens (Schmalblättriges Greiskraut) (1)
- Sepsis-bundle (1)
- Serum (1)
- Shell model (1)
- Shunt (1)
- Single muons (1)
- Social determinants (1)
- SoftDrop (1)
- Solar insolation (1)
- Spectrin (1)
- Spectroscopic factors & electromagnetic moments (1)
- Spin alignment (1)
- Spinal fractures (1)
- Spinal injuries (1)
- Spine care (1)
- Spirochetes (1)
- Splitting function (1)
- Standardization (1)
- Standards of care (1)
- Static MRI (1)
- Statistical analysis (1)
- Status epilepticus (1)
- Stenotrophomonas maltophilia (1)
- Steroid (1)
- Strangeness enhancement (1)
- Sub-segmentation (1)
- Sunlight (1)
- Superinfection (1)
- Surgery (1)
- Surgical risk (1)
- Survival analysis (1)
- Survival data (1)
- Synthetic (1)
- Systematic Uncertainty (1)
- T-cell (1)
- TACE (1)
- TGF-beta (1)
- TIPS (1)
- TR (1)
- Tea (1)
- Technical data (1)
- Technique (1)
- Techniques Electromagnetic calorimeters (1)
- Temporal lobe epilepsy (1)
- Temporomandibular joint (1)
- Temporomandibular joint dysfunction (1)
- Thermal model (1)
- Thoracic aortic aneurysm (1)
- Threshold effect (1)
- Thrombosis (1)
- Time Projection Chamber (1)
- Timing (1)
- Tomography (1)
- Tracking (1)
- Transcriptional Control (1)
- Transcriptome analysis (1)
- Transition radiation detector (1)
- Transjugular Intrahepatic Portosystemic Shunt (1)
- Translational research (1)
- Transverse momentum (1)
- Transversity (1)
- Trauma (1)
- Treatment (1)
- Treatment outcome (1)
- Trigger (1)
- Tropidosteptes (1)
- Truncus arteriosus (1)
- Tumor volume (1)
- UAV (1)
- UWB diagnostics (1)
- Upper respiratory tract infection (1)
- Vaccination (1)
- Vascular emergencies (1)
- Vector Boson Production (1)
- Vektoranalysis (1)
- Verbal fluency (1)
- Vertebral body (1)
- Virtual noncalcium reconstructions (1)
- Vitamin (1)
- Vorsorgeuntersuchung (1)
- Wang resin (1)
- Workstation comparison (1)
- Worldwide Protein Data Bank (1)
- Wounds (1)
- Währungssystem (1)
- X-ray computed (1)
- X-ray crystallography (1)
- X-rays (1)
- Xenon-based gas mixture (1)
- Y states (1)
- Zagros (1)
- abdominal imaging (1)
- acute leukemia (1)
- adaptation (1)
- airway (1)
- alleles (1)
- amino acids (1)
- amphibians (1)
- anchialine (1)
- anchialine cave (1)
- angiography (1)
- animal migration (1)
- antibaryon (1)
- antibiotic therapy (1)
- antiepileptic drugs (1)
- antimicrobial stewardship (1)
- aortic stenosis (1)
- ascites (1)
- autism spectrum disorder (1)
- autistic disorder (1)
- axions (1)
- beads (1)
- behavioural ecology (1)
- biodiversity (1)
- bioenergetics (1)
- biogeographic legaciese (1)
- biomarker (1)
- biome stability (1)
- biopsy (1)
- birds (1)
- bladder exstrophy-epispadias complex (1)
- c-MET (1)
- cPLA2 (1)
- cabozantinib (1)
- calcium-independent phospholipase A2β (1)
- calretinin (1)
- cancer (1)
- carbapenem resistance (1)
- cardiac magnetic resonance (1)
- cardiac remodeling (1)
- cave (1)
- cell lines (1)
- center-of-mass energy (1)
- ceramide synthase (1)
- charmonium-like states (1)
- cholestasis (1)
- chromosomal translocations (1)
- chronic liver disease (CLD) (1)
- cisplatin (1)
- climate-change ecology (1)
- cloacal malformation (1)
- collision (1)
- colon (1)
- colonization (1)
- colorectal cancer (1)
- colorectal cancer (CRC) (1)
- colorectal cancer liver metastases (CRLM) (1)
- computer tomography (1)
- computer-assisted (1)
- cone-beam computed tomography (CBCT) (1)
- cone-beam computer tomography (1)
- conservation biology (1)
- continental climate (1)
- conventional/traditional transarterial chemoembolization (cTACE) (1)
- copy number polymorphism (1)
- critical care unit (1)
- critical ill patients (1)
- cryoelectron microscopy (1)
- cryptic species (1)
- cytotoxicity (1)
- dE/dx (1)
- dark matter experiments (1)
- denervation (1)
- dentate gyrus (1)
- detector (1)
- deuteron (1)
- diagnostic imaging (1)
- dimuon (1)
- disease prevalence (1)
- domestication (1)
- drone (1)
- drug-eluting beads TACE (DEB-TACE) (1)
- dual-energy (1)
- e+e − annihilation (1)
- e+e⁻ − Experiments (1)
- e+e− Experiments (1)
- ecosystem services (1)
- ectosomes (1)
- electromagnetic navigation bronchoscopy (EMN, ENB) (1)
- electron-positron collision (1)
- emergence (1)
- endemic bird areas (1)
- endemic species (1)
- epigenomics (1)
- evolution (1)
- excitation (1)
- exhaustion (1)
- exosomes (1)
- experimental results (1)
- extracellular vesicles (1)
- f-MLF (1)
- fear conditioning (1)
- fibrosis (1)
- fine spatial resolution remote sensing (1)
- fitness (1)
- flurbiprofen (1)
- forest classification (1)
- forest functional similarity (1)
- formylation (1)
- functional genetics (1)
- gadobutrol (1)
- gene flow (1)
- genes (1)
- genetic distance (1)
- genetic generalized epilepsy (1)
- genetics (1)
- genome (1)
- genotype (1)
- genotype determination (1)
- germination (1)
- glioblastoma (1)
- guanidine alkaloid (1)
- guidelines (1)
- habitat destruction (1)
- hadron spectroscopy (1)
- hadronic events (1)
- healthcare professional (1)
- heart failure (1)
- heavy ion experiments (1)
- heavy-ion collisions (1)
- helicity amplitude analysis (1)
- hepatocellular carcinoma (HCC) (1)
- high energie (1)
- high-pitch (1)
- highly-charged ions (1)
- hohe Energie (1)
- host (1)
- hypertension, pulmonary (1)
- imaging (1)
- impulsivity (1)
- in vivo dosimetry (1)
- inclusive J/ψ decays (1)
- infection control (1)
- inflammasome (1)
- injury (1)
- inner membrane morphology (1)
- integrated stratigraphy (1)
- interleukin-1β (1)
- interventional radiology (1)
- intraarterial therapy (1)
- intratumoral (1)
- irinotecan-loaded drug-eluting beads TACE (DEBIRI-TACE) (1)
- kidney formation (1)
- lamotrigine (1)
- land use (1)
- laser-induced thermotherapy (1)
- layer-specificity (1)
- learning (1)
- levetiracetam (1)
- lichen extracts (1)
- lipiodol (1)
- liver cirrhosis (1)
- liver metastases (1)
- liver transplantation (1)
- livermetastases of colorectal cancer (1)
- locoregional chemotherapy (1)
- low-dose imaging (1)
- lung cancer (1)
- mTOR (1)
- magic-angle spinning (1)
- maladaptation (1)
- mammals (1)
- mantle cell lymphoma (1)
- marker (1)
- mast cells (1)
- medial prefrontal cortex (mPFC) (1)
- membrane protein complex (1)
- memory consolidation and extinction (1)
- microdosing (1)
- microparticles (1)
- microvesicles (1)
- microwave breast imaging (1)
- migration (1)
- minimal information requirements (1)
- mitochondria (1)
- molecular dynamics simulation (1)
- multidetector computed tomography (1)
- multidrug resistance (1)
- multilevel latent polynomial regression analysis (1)
- myocardial fibrosis (1)
- nRNA Complexity (1)
- natural product (1)
- neovascularization, physiologic (1)
- neurofeedback (1)
- neutralizing antibodies (1)
- neutrophils (1)
- nitrogen (1)
- non‑Hodgkin's lymphoma (1)
- nuclear (1)
- nucleon (1)
- number of J/ψ events (1)
- orbital forcing (1)
- organotypic culture (1)
- oval split ring resonator (1)
- overall survival (OS) (1)
- p+p collisions (1)
- papilloma (1)
- patient study (1)
- percutaneous thermal ablation (1)
- perforant path transection (1)
- peripheral blood stem cell transplant (1)
- pharmacoresistance (1)
- phenotype (1)
- phylogenetic community distance (1)
- phylogeny (1)
- plant height (1)
- portal vein (1)
- primary biliary cirrhosis (1)
- primary sclerosing cholangitis (1)
- progression-free survival (PFS) (1)
- pulmonary hypertension (1)
- quark gluon plasma (1)
- radiation (1)
- radiation dosage (1)
- radiation dosimetry (1)
- radiation protection (1)
- radiomics (1)
- rats (1)
- relativistic collisions (1)
- renal impairment (1)
- reproducibility (1)
- reptiles (1)
- resistant cell lines (1)
- resolution (1)
- retuximab (1)
- rigor (1)
- rosacea (1)
- rotary ATPase mechanism (1)
- sagebrush (1)
- scar (1)
- schizophrenia (1)
- screening (1)
- screening routine (1)
- sepsis (1)
- sex‑determining region Y-box 11 (1)
- single nucleotide polymorphism (1)
- single subject classification (1)
- skin involvement (1)
- social identity (1)
- sodium bituminosulfonate (1)
- solar physics (1)
- solitary pulmonary nodule (1)
- space-momentum correlation (1)
- spectra (1)
- sphingosine kinase (1)
- sphingosine-1-phosphate (1)
- spike protein (1)
- spine (1)
- squamous cell carcinoma (1)
- standardization (1)
- stent (1)
- storage rings (1)
- structure-from-motion photogrammetry (1)
- symbiosis (1)
- system (1)
- temporal classification (1)
- tetraquark (1)
- theranostics (1)
- thrombosis (1)
- tivantinib (1)
- toll-like receptor (1)
- tracheobronchomalacia (1)
- transarterial chemoembolization (TACE) (1)
- transbronchial biopsy (TBB) (1)
- transcranial magnetic stimulation (TMS) (1)
- translocation partner genes (1)
- transmission (1)
- trigger efficiency (1)
- tropical forests (1)
- tumor (1)
- tumor response (1)
- tumor suppressor (1)
- urinary tract development (1)
- valproic acid (1)
- variants of concern (1)
- vertebroplasty (1)
- virtual reality (1)
- white and brown dwarfs (1)
- whole-genome sequencing (1)
- wwPDB (1)
- x-ray techniques (1)
- yeast (1)
- zebrafish development (1)
- Öffentlichkeit (1)
- Λ+c baryon (1)
- Σ hyperon (1)
- Υ suppression (1)
- ψ(3686) (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (1406)
- Frankfurt Institute for Advanced Studies (FIAS) (1069)
- Informatik (925)
- Medizin (168)
- Geowissenschaften (23)
- Biowissenschaften (19)
- Biochemie und Chemie (14)
- Biodiversität und Klima Forschungszentrum (BiK-F) (12)
- Senckenbergische Naturforschende Gesellschaft (9)
- Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) (8)
The change in allele frequencies within a population over time represents a fundamental process of evolution. By monitoring allele frequencies, we can analyze the effects of natural selection and genetic drift on populations. To efficiently track time-resolved genetic change, large experimental or wild populations can be sequenced as pools of individuals sampled over time using high-throughput genome sequencing (called the Evolve & Resequence approach, E&R). Here, we present a set of experiments using hundreds of natural genotypes of the model plant Arabidopsis thaliana to showcase the power of this approach to study rapid evolution at large scale. First, we validate that sequencing DNA directly extracted from pools of flowers from multiple plants -- organs that are relatively consistent in size and easy to sample -- produces comparable results to other, more expensive state-of-the-art approaches such as sampling and sequencing of individual leaves. Sequencing pools of flowers from 25-50 individuals at ∼40X coverage recovers genome-wide frequencies in diverse populations with accuracy r > 0.95. Secondly, to enable analyses of evolutionary adaptation using E&R approaches of plants in highly replicated environments, we provide open source tools that streamline sequencing data curation and calculate various population genetic statistics two orders of magnitude faster than current software. To directly demonstrate the usefulness of our method, we conducted a two-year outdoor evolution experiment with A. thaliana to show signals of rapid evolution in multiple genomic regions. We demonstrate how these laboratory and computational Pool-seq-based methods can be scaled to study hundreds of populations across many climates.
The aim of this study was to detect a response difference in primary (PLC) and secondary liver tumors (SLC) with magnetic resonance elastography (MRE) after TACE therapy. Thirty-one patients (25/31 male; mean age 69.6 years [range: 39–85 years]) with repeated TACE therapy of HCC were compared with twenty-seven patients (27/27 female; mean age 61.2 years [range 39–81 years]) with repeated TACE therapy of metastatic liver disease due to breast cancer. Both groups underwent either one (n = 31) or two (n = 27) repetitive magnetic resonance imaging (MRI) and MRE exams in 4- to 6-week intervals using a 1.5-T-scanner. MRE-based liver stiffness and size measurements were evaluated in tumorous lesions and in healthy liver lobe controls. PLC showed a significantly larger tumor size compared to SLC (26.4 cm2 vs. 11 cm2, p = 0.007) and a higher degree of stiffness (5.8 kPa vs. 5.1 kPa, p = 0.04). Both tumors decreased in size during the cycles (PLC: p = 0.8 and SLC: p < 0.0001) and lesions showed an increase in stiffness (PLC: p = 0.002 and SLC: p = 0.006). MRE demonstrates that PLC and SLC have similar responses to TACE therapy. PLC had a greater increase in stiffness and SLC got smaller. An increasing stiffness and decrease in size could show a good response.
Dr. Heiner Schnelling (58) ist Anglist und Germanist. Zuletzt Leiter der Universitätt- und Landesbibiiothek in Halle an der Saale, wird er zum 1. Oktober Nachfolger von Dr. Berndt Dugall als Leiter der Unibibliothek Frankfurt. Thomas J. Schmidt hat mit ihm über den Umzug der UB und die Zukunft des Buchs gesprochen.
Background: Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography.
Methods: In a systematic review of OVID MEDLINE—with additional hand-searching of relevant studies' bibliographies— from Jan 1, 1970, to Dec 31, 2015, we identified observational cohorts and randomised trials with repeat scanning protocols that included at least ten patients with acute intracerebral haemorrhage. We sought individual patient-level data from corresponding authors for patients aged 18 years or older with data available from brain imaging initially done 0·5–24 h and repeated fewer than 6 days after symptom onset, who had baseline intracerebral haemorrhage volume of less than 150 mL, and did not undergo acute treatment that might reduce intracerebral haemorrhage volume. We estimated the absolute risk and predictors of the primary outcome of intracerebral haemorrhage growth (defined as >6 mL increase in intracerebral haemorrhage volume on repeat imaging) using multivariable logistic regression models in development and validation cohorts in four subgroups of patients, using a hierarchical approach: patients not taking anticoagulant therapy at intracerebral haemorrhage onset (who constituted the largest subgroup), patients taking anticoagulant therapy at intracerebral haemorrhage onset, patients from cohorts that included at least some patients taking anticoagulant therapy at intracerebral haemorrhage onset, and patients for whom both information about anticoagulant therapy at intracerebral haemorrhage onset and spot sign on acute CT angiography were known.
Findings: Of 4191 studies identified, 77 were eligible for inclusion. Overall, 36 (47%) cohorts provided data on 5435 eligible patients. 5076 of these patients were not taking anticoagulant therapy at symptom onset (median age 67 years, IQR 56–76), of whom 1009 (20%) had intracerebral haemorrhage growth. Multivariable models of patients with data on antiplatelet therapy use, data on anticoagulant therapy use, and assessment of CT angiography spot sign at symptom onset showed that time from symptom onset to baseline imaging (odds ratio 0·50, 95% CI 0·36–0·70; p<0·0001), intracerebral haemorrhage volume on baseline imaging (7·18, 4·46–11·60; p<0·0001), antiplatelet use (1·68, 1·06–2·66; p=0·026), and anticoagulant use (3·48, 1·96–6·16; p<0·0001) were independent predictors of intracerebral haemorrhage growth (C-index 0·78, 95% CI 0·75–0·82). Addition of CT angiography spot sign (odds ratio 4·46, 95% CI 2·95–6·75; p<0·0001) to the model increased the C-index by 0·05 (95% CI 0·03–0·07).
Interpretation: In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination. These models could inform the location and frequency of observations on patients in clinical practice, explain treatment effects in prior randomised trials, and guide the design of future trials.
Funding: UK Medical Research Council and British Heart Foundation.
Iran is a huge but understudied Middle Eastern country with a rich but chronically understudied bee fauna, including for the highly-speciose bee genus Andrena. Examination of unidentified museum material combined with recent field collections and a critical review of the literature has revealed a total of 197 species of Andrena in the Iranian fauna, of which 65 are newly reported for the country, with an additional 16 species new for science. Andrena (Aciandrena) deminuta Wood sp. nov., Andrena (Euandrena) boustaniae Wood sp. nov., Andrena (Euandrena) oblata sp. nov., Andrena (Euandrena) sani sp. nov., Andrena (Micrandrena) elam Wood sp. nov., Andrena (Micrandrena) subviridula Wood sp. nov., Andrena (Notandrena) idigna Wood sp. nov., Andrena (Planiandrena) flagrans Wood sp. nov., Andrena (Planiandrena) sella Wood sp. nov., Andrena (Ulandrena) bulbosa Wood sp. nov., Andrena (incertae sedis) hosseiniiae Wood & Monfared sp. nov., and Andrena (incertae sedis) rostamiae sp. nov. are described from Iran, Andrena (Micrandrena) extenuata sp. nov. is described from Iran and Syria, Andrena (Micrandrena) tabula Wood sp. nov. and Andrena (Micrandrena) obsidiana Wood sp. nov. are described from Iran and Turkey, and Andrena (Planiandrena) huma sp. nov. is described from Iran, Syria, and the Golan Heights. Eight taxa are synonymised (valid name first): Andrena (Melandrena) assimilis Radoszkowski, 1876 = Andrena (Melandrena) gallica Schmiedeknecht, 1883 syn. nov.; Andrena (Notandrena) emesiana Pérez, 1911 stat. resurr. = Andrena (Notandrena) recurvirostra Warncke, 1975 syn. nov.; Andrena (Plastandrena) eversmanni Radoszkowski, 1867 = Andrena (Plastandrena) peshinica Nurse, 1904 syn. nov.; Andrena (incertae sedis) hieroglyphica Morawitz, 1876 = Andrena (Carandrena) cara Nurse, 1904 syn. nov. and Andrena (Carandrena) halictoides Nurse, 1904 syn. nov.; Andrena (Melandrena) induta Morawitz, 1894 = Andrena (Melandrena) patella Nurse, 1903 syn. nov.; Andrena (incertae sedis) minor Warncke, 1975 stat. nov. = Andrena (Carandrena) splendula Osytshnjuk, 1984 syn. nov.; Andrena (Notandrena) zostera Warncke, 1975 = Andrena (Carandrena) subsmaragdina Osytshnjuk, 1984 syn. nov. Overall, these results considerably improve our understanding of the Iranian Andrena fauna, and suggest that overall bee diversity in this country is substantially more than 1000 species.
Chlamydia are obligate intracellular bacteria that cause variety of human diseases. Host cells infected with Chlamydia are protected against many different apoptotic stimuli. The induction of apoptosis resistance is thought to be an important immune escape mechanism allowing Chlamydia to replicate inside the host cell. Infection with C. trachomatis activates the Raf/MEK/ERK pathway and the PI3K/AKT pathway. Here we show that inhibition of these two pathways by chemical inhibitors sensitized C. trachomatis infected cells to granzyme B-mediated cell death. Infection leads to the Raf/MEK/ERK-mediated up-regulation and PI3K-dependent stabilization of the anti-apoptotic Bcl-2 family member Mcl-1. Consistently, interfering with Mcl-1 up-regulation sensitized infected cells for apoptosis induced via the TNF receptor, DNA damage, granzyme B and stress. Our data suggest that Mcl-1 up-regulation is primarily required to maintain apoptosis resistance in C. trachomatis-infected cells.
Bibliothek statt Tankstelle : Dezernent bringt neuen Standort für Uni-Bibliothek ins Gespräch
(2018)
Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms
(2017)
Aim: To assess the correlation of lateral recess stenosis (LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index (ODI).
Methods: Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study. On magnetic resonance images (MRI) the lateral recesses (LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale (Grade 0-3) as normal, not deviated, deviated or compressed. Patient symptoms and disability were assessed using ODI. The Spearman’s rank correlation coefficient was used for statistical analysis (P < 0.05).
Results: Approximately half of the LR revealed stenosis (grade 1-3; 52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression. The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%. We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1, each bilaterally (L4/5 left: rho < 0.105, P < 0.01; L4/5 right: rho < 0.111, P < 0.01; L5/S1 left: rho 0.128, P < 0.01; L5/S1 right: rho < 0.157, P < 0.001).
Conclusion: Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis, this study showed only a weak correlation of LRS on MRI and clinical findings. This can be attributed to a number of reasons outlined in this study, underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS.
The idea of slow-neutron capture nucleosynthesis formulated in 1957 triggered a tremendous experimental effort in different laboratories worldwide to measure the relevant nuclear physics input quantities, namely (n,γ) cross sections over the stellar temperature range (from few eV up to several hundred keV) for most of the isotopes involved from Fe up to Bi. A brief historical review focused on total energy detectors will be presented to illustrate how, advances in instrumentation have led, over the years, to the assessment and discovery of many new aspects of s-process nucleosynthesis and to the progressive refinement of theoretical models of stellar evolution. A summary will be presented on current efforts to develop new detection concepts, such as the Total-Energy Detector with γ-ray imaging capability (i-TED). The latter is based on the simultaneous combination of Compton imaging with neutron time-of-flight (TOF) techniques, in order to achieve a superior level of sensitivity and selectivity in the measurement of stellar neutron capture rates.
Fission program at n_TOF
(2019)
Since its start in 2001 the n_TOF collaboration developed a measurement program on fission, in view of advanced fuels in new generation reactors. A special effort was made on measurement of cross sections of actinides, exploiting the peculiarity of the n_TOF neutron beam which spans a huge energy domain, from the thermal region up to GeV. Moreover fission fragment angular distributions have also been measured. An overview of the cross section results achieved with different detectors is presented, including a discussion of the 237Np case where discrepancies showed up between different detector systems. The results on the anisotropy of the fission fragments and its implication on the mechanism of neutron absorption, and in applications, are also shown.
Diverse extracellular signals induce plasma membrane translocation of sphingosine kinase-1 (SphK1), thereby enabling inside-out signaling of sphingosine-1-phosphate. We have shown before that Gq-coupled receptors and constitutively active Gαq/11 specifically induced a rapid and long-lasting SphK1 translocation, independently of canonical Gq/phospholipase C (PLC) signaling. Here, we further characterized Gq/11 regulation of SphK1. SphK1 translocation by the M3 receptor in HEK-293 cells was delayed by expression of catalytically inactive G-protein-coupled receptor kinase-2, p63Rho guanine nucleotide exchange factor (p63RhoGEF), and catalytically inactive PLCβ3, but accelerated by wild-type PLCβ3 and the PLCδ PH domain. Both wild-type SphK1 and catalytically inactive SphK1-G82D reduced M3 receptor-stimulated inositol phosphate production, suggesting competition at Gαq. Embryonic fibroblasts from Gαq/11 double-deficient mice were used to show that amino acids W263 and T257 of Gαq, which interact directly with PLCβ3 and p63RhoGEF, were important for bradykinin B2 receptor-induced SphK1 translocation. Finally, an AIXXPL motif was identified in vertebrate SphK1 (positions 100–105 in human SphK1a), which resembles the Gαq binding motif, ALXXPI, in PLCβ and p63RhoGEF. After M3 receptor stimulation, SphK1-A100E-I101E and SphK1-P104A-L105A translocated in only 25% and 56% of cells, respectively, and translocation efficiency was significantly reduced. The data suggest that both the AIXXPL motif and currently unknown consequences of PLCβ/PLCδ(PH) expression are important for regulation of SphK1 by Gq/11.
Einleitung: Für die meisten Patienten mit HCC ist die LTX die einzige kurative Behandlungsoption. Bei diesen Patienten scheint eine Kontrolle der Erkrankung durch lokale Verfahren im Intervall bis zur LTX zu erreichen zu sein. Als das beste Verfahren gilt die transarterielle Chemoembolisation (TACE). Die Effektivität ist jedoch umstritten. Möglicherweise kann sie aber Patienten startifizieren, die ein hohes Rezidivrisiko haben.
Material und Methoden: Im Zeitraum zwischen 1995 und 2005 wurden n=27 Patienten mit HCC im Alter zwischen 22 und 69 Jahren transplantiert. Hiervon erhielten n=15 Patienten eine Vorbehandlung in Form einer alleinigen TACE oder kombiniert mit PEI [n=1] bzw. LITT [n=1]. Retrospektiv wurde das Gesamtüberleben sowie das „Event-free-survival“ (Rezidiv, Reinfektion und Tod) analysiert.
Ergebnisse: Die mittlere Wartezeit betrug bei Patienten in der TACE-Gruppe 214 Tage, bei Patienten ohne Vorbehandlung 133 Tage. Bei einem mittleren Nachbeobachtungszeitraum von 1097 ± 1193 Tagen für TACE-Patienten und 1674 ± 966 Tagen für non-TACE-Patienten betrug das Überleben für Patienten, die mit TACE vorbehandelt wurden 83,3%, für Patienten, die keine TACE erhielten 86.7% (p=0,5693). Gleiches fand sich für das Event-free-survival (p=0,8823). Das Gesamtüberleben der Patienten, die auf der Warteliste einen Tumorprogress hatten lag bei 77%, während Patienten mit stabiler Tumorgröße oder Regredienz der Tumore ein Überleben von 93% aufwiesen (p=0,0153). Unter TACE-Behandlung zeigten 5/15 Patienten eine zunehmende Anzahl an Herden im histologischen Präparat verglichen mit der Ausgangsbildgebung. Nur bei einem Patienten zeigte sich der Progress der Erkrankung bereits in der präoperativen Bildgebung. Patienten mit einem Progress der Erkrankung hatten ein Gesamtüberleben von 60%, während Patienten mit „stable disease“ oder Rückgang der Herde ein Gesamtüberleben von 100% hatten (p=0,0180).
Schlussfolgerung: Unseren Ergebnisse zufolge ist der Effekt der TACE als Bridgingverfahren auf das Überleben der Patienten fraglich. Allerdings scheint die TACE zur Riskostratifizierung geeignet zu sein. In unserem Patientenkollektiv hatten Patienten, die eine Progredienz der Erkrankung auf der Warteliste zeigten ein signifikant schlechteres Gesamtüberleben. Dies gilt auch bei ausschließlicher Betrachtung der Patienten mit TACE.
Objective: To investigate the accuracy, efficiency and radiation dose of a novel laser navigation system (LNS) compared to those of free-handed punctures on computed tomography (CT).
Materials and methods: Sixty punctures were performed using a phantom body to compare accuracy, timely effort, and radiation dose of the conventional free-handed procedure to those of the LNS-guided method. An additional 20 LNS-guided interventions were performed on another phantom to confirm accuracy. Ten patients subsequently underwent LNS-guided punctures.
Results: The phantom 1-LNS group showed a target point accuracy of 4.0 ± 2.7 mm (freehand, 6.3 ± 3.6 mm; p = 0.008), entrance point accuracy of 0.8 ± 0.6 mm (freehand, 6.1 ± 4.7 mm), needle angulation accuracy of 1.3 ± 0.9° (freehand, 3.4 ± 3.1°; p < 0.001), intervention time of 7.03 ± 5.18 minutes (freehand, 8.38 ± 4.09 minutes; p = 0.006), and 4.2 ± 3.6 CT images (freehand, 7.9 ± 5.1; p < 0.001). These results show significant improvement in 60 punctures compared to freehand. The phantom 2-LNS group showed a target point accuracy of 3.6 ± 2.5 mm, entrance point accuracy of 1.4 ± 2.0 mm, needle angulation accuracy of 1.0 ± 1.2°, intervention time of 1.44 ± 0.22 minutes, and 3.4 ± 1.7 CT images. The LNS group achieved target point accuracy of 5.0 ± 1.2 mm, entrance point accuracy of 2.0 ± 1.5 mm, needle angulation accuracy of 1.5 ± 0.3°, intervention time of 12.08 ± 3.07 minutes, and used 5.7 ± 1.6 CT-images for the first experience with patients.
Conclusion: Laser navigation system improved accuracy, duration of intervention, and radiation dose of CT-guided interventions.
To analyze prospectively the interventional and clinical aspects of computed tomography-guided direct intratumoural injection of a novel chemotherapeutic administration and the parenchymal changes of tumour and necrosis in malignant liver tumours. Eight patients with 17 colorectal liver metastases were treated with a mean of 5.1 injections and nine patients with 13 hepatocellular carcinoma nodules with a mean of 3.1 treatments with computed tomography guided local applications of a novel cisplatin/epinephrine gel. This application provides a higher local and lower systemic drug concentration. Volumes of tumour and necrosis prior and after treatment were measured by computer generated volumetric analysis. Contrast enhanced studies verified pretherapeutic viable tumour volumes with a value of 77.4 ml in the metastases and 29.2 ml in the hepatocellular carcinoma nodules. Intratumoural drug application resulted in a significant increase of necrosis and a decrease in viable tumour volume to be 68.3 ml in metastases and 14.5 ml in hepatocellular carcinoma. Local therapy control rate for the follow up to 6 months was 38 and 71% for the group of metastases and hepatocellular carcinoma, respectively. Direct intratumoural injection of cisplatin/epinepthrine injectable gel is a feasible and good tolerated method and results in the development of a statistically significant increase in necrosis in malignant liver tumours. For hepatocellular carcinoma a higher local therapy control rate compared to colorectal metastases can be reported.
During the measurement campaign FROST 2 (FReezing Of duST 2), the Leipzig Aerosol Cloud Interaction Simulator (LACIS) was used to investigate the influence of various surface modifications on the ice nucleating ability of Arizona Test Dust (ATD) particles in the immersion freezing mode. The dust particles were exposed to sulfuric acid vapor, to water vapor with and without the addition of ammonia gas, and heat using a thermodenuder operating at 250 °C. Size selected, quasi monodisperse particles with a mobility diameter of 300 nm were fed into LACIS and droplets grew on these particles such that each droplet contained a single particle. Temperature dependent frozen fractions of these droplets were determined in a temperature range between −40 °C ≤T≤−28 °C. The pure ATD particles nucleated ice over a broad temperature range with their freezing behavior being separated into two freezing branches characterized through different slopes in the frozen fraction vs. temperature curves. Coating the ATD particles with sulfuric acid resulted in the particles' IN potential significantly decreasing in the first freezing branch (T>−35 °C) and a slight increase in the second branch (T≤−35 °C). The addition of water vapor after the sulfuric acid coating caused the disappearance of the first freezing branch and a strong reduction of the IN ability in the second freezing branch. The presence of ammonia gas during water vapor exposure had a negligible effect on the particles' IN ability compared to the effect of water vapor. Heating in the thermodenuder led to a decreased IN ability of the sulfuric acid coated particles for both branches but the additional heat did not or only slightly change the IN ability of the pure ATD and the water vapor exposed sulfuric acid coated particles. In other words, the combination of both sulfuric acid and water vapor being present is a main cause for the ice active surface features of the ATD particles being destroyed. A possible explanation could be the chemical transformation of ice active metal silicates to metal sulfates. The strongly enhanced reaction between sulfuric acid and dust in the presence of water vapor and the resulting significant reductions in IN potential are of importance for atmospheric ice cloud formation. Our findings suggest that the IN concentration can decrease by up to one order of magnitude for the conditions investigated.
During the measurement campaign FROST 2 (FReezing Of duST 2), the Leipzig Aerosol Cloud Interaction Simulator (LACIS) was used to investigate the influences of various surface modifications on the immersion freezing behavior of Arizona Test Dust (ATD) particles. The dust particles were exposed to sulfuric acid vapor, to water vapor with and without the addition of ammonia gas, and heat using a thermodenuder operating at 250 °C. Size selected, quasi monodisperse particles with a mobility diameter of 300 nm were fed into LACIS and droplets grew on these particles such that each droplet contained a single particle. Temperature dependent frozen fractions of these droplets were determined in a temperature range between −40 °C ≤ T ≤ −28 °C. The pure ATD particles nucleated ice over a~broad temperature range with their freezing behavior being separated into two freezing branches characterized through different slopes in the frozen fraction vs. temperature curves. Coating the ATD particles with sulfuric acid resulted in the particles' IN potential significantly decreasing in the first freezing branch (T > −35 °C) and a slight increase in the second branch (T≤ −35 °C). The addition of water vapor after the sulfuric acid coating caused the disappearance of the first freezing branch and a strong reduction of the IN ability in the second freezing branch. The presence of ammonia gas during water vapor exposure had a negligible effect on the particles' IN ability compared to the effect of water vapor. Heating in the thermodenuder led to a decreased IN ability of the sulfuric acid coated particles for both branches but the additional heat did not or only slightly change the IN ability of the pure ATD and the water vapor exposed sulfuric acid coated particles. In other words, the combination of both sulfuric acid and water vapor being present is a main cause for the ice active surface features of the ATD particles being destroyed. A possible explanation could be the chemical transformation of ice active metal silicates to metal sulfates. From an atmospheric point of view, and here specifically the influences of atmospheric aging on the IN ability of dust particles, the strongly enhanced reaction between sulfuric acid and dust in the presence of water vapor, and the resulting significant reductions in IN potential, are certainly very interesting.
The slow neutron capture process (s-process) is responsible for producing about half of the elemental abundances heavier than iron in the universe. Neutron capture cross sections on stable isotopes are a key nuclear physics input for s-process studies. The 72Ge(n, γ) cross section has an important influence on production of isotopes between Ge and Zr during s-process in massive stars and therefore experimental data are urgently required. 72Ge(n, γ) was measured at the neutron time-of-flight facility n_TOF (CERN) for the first time at stellar energies. The measurement was performed using an enriched 72GeO2 sample at a flight path of 185m with a set of liquid scintillation detectors (C6D6). The motivation, experiment and current status of the data analysis are reported.