Refine
Document Type
- Article (5)
Language
- English (5)
Has Fulltext
- yes (5)
Is part of the Bibliography
- no (5)
Keywords
- CD4 binding site (1)
- Data sharing (1)
- HIV-1 (1)
- HIV-1 escape restriction (1)
- broadly neutralizing antibodies (1)
- cryogenic electron microscopy (1)
- deep mutational scanning (1)
- escape mutations (1)
- global change (1)
- habitat destruction (1)
- humanized mice (1)
- immunotherapy (1)
- land use (1)
- mutational antigenic profiling (1)
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope glycoprotein (Env) limits clinical applications. Here we describe 1-18, a new VH1-46-encoded CD4 binding site (CD4bs) bNAb with outstanding breadth (97%) and potency (GeoMean IC50 = 0.048 μg/mL). Notably, 1-18 is not susceptible to typical CD4bs escape mutations and effectively overcomes HIV-1 resistance to other CD4bs bNAbs. Moreover, mutational antigenic profiling uncovered restricted pathways of HIV-1 escape. Of most promise for therapeutic use, even 1-18 alone fully suppressed viremia in HIV-1-infected humanized mice without selecting for resistant viral variants. A 2.5-Å cryo-EM structure of a 1-18-BG505SOSIP.664 Env complex revealed that these characteristics are likely facilitated by a heavy-chain insertion and increased inter-protomer contacts. The ability of 1-18 to effectively restrict HIV-1 escape pathways provides a new option to successfully prevent and treat HIV-1 infection.
Floristic composition and environmental relationships of Sphagnum-dominated communities in Victoria
(2003)
Floristic community types and their environmental correlates are described for Sphagnum-dominated communities throughout Victoria. Current threats to the condition of these communities are outlined, with an assessment of their conservation status. Sites from lowland (350 m) to alpine (1780 m) areas were surveyed and seven floristic groups were recognised using cluster analysis and non-metric multi-dimensional scaling techniques. The strongest floristic gradients corresponded to altitude, temperature, rainfall, geology and current condition. Several of the sites surveyed were degraded, with some sites heavily impacted by cattle grazing or invaded by weeds. While some floristic groups, particularly sub-alpine bogs, are reserved in national parks, others such as montane and lowland bogs occur on forestry and private land tenures. Reservation has not protected some sites from threatening processes, most notably in alpine national parks, where cattle grazing has seriously degraded many of these Sphagnum peatland communities to either disclimax communities or isolated moss beds no longer functioning ecologically as peatlands. Further surveys of Sphagnum-dominated communities elsewhere in Victoria are warranted, especially montane and lowland areas. The results suggest Sphagnum-dominated communities will require conservation planning and management action throughout their geographic range in Victoria.
Floristic variation in Sphagnum-dominated peatland communities of the Central Highlands, Victoria
(2007)
The floristic composition of Sphagnum-dominated peatlands in the Central Highlands region of Victoria was surveyed (37º 25´ S; 145º 50´ E). NMDS ordination and cluster analysis divided the peatland sites into two broad groups with altitude being the most important factor separating these groups. Other important factors were aspect, slope and the amount of shade. Group 1 included subalpine sites that are similar to those found at higher altitudes further east in Victoria. Important species included Empodisma minus, Epacris paludosa, Richea continentis and Baeckea gunniana. The two species of Sphagnum present were Sphagnum cristatum and the more inundation-tolerant Sphagnum novozelandicum. Group 2 included montane peatlands with abundant Sphagnum cristatum. These sites range from broad wet heaths dominated by Richea victoriana and Carex appressa, to narrower cool temperate rainforest and riparian systems. The ‘rainforest’ peatlands are characterised by Leptospermum grandifolium, Nothofagus cunninghamii, Carex appressa and Blechnum penna-marina, and are in varying stages of post-fire succession regulated by sitespecific microclimate. The conservation status and catchment function of these peatlands are briefly discussed.