Filtern
Dokumenttyp
- Konferenzveröffentlichung (6) (entfernen)
Sprache
- Englisch (6)
Volltext vorhanden
- ja (6)
Gehört zur Bibliographie
- nein (6)
Schlagworte
Institut
- Physik (4)
- Extern (1)
- Georg-Speyer-Haus (1)
- Medizin (1)
- Pharmazie (1)
Low energy beam transport (LEBT) for a future heavy ion driven inertial fusion (HIDIF [1]) facility is a crucial point using a Bi+ beam of 40 mA at 156 keV. High space charge forces (generalised perveance K=3.6*10-3) restrict the use of electrostatic focussing systems. On the other hand magnetic lenses using space charge compensation suffer from the low particle velocity. Additionally the emittance requirements are very high in order to avoid particle losses in the linac and at ring injection [2]. urthermore source noise and rise time of space charge compensation [3] might enhance particle losses and emittance. Gabor lenses [4] using a continuous space charge cloud for focussing could be a serious alternative to conventional LEBT systems. They combine strong cylinder symmetric focussing with partly space charge compensation and low emittance growth due to lower non linear fields. A high tolerance against source noise and current fluctuations and reduced investment costs are other possible advantages. The proof of principle has already been shown [5, 6]. To broaden the experiences an experimental program was started. Therefrom the first experimental results using a double Gabor lens (DGPL, see fig. 1 ) LEBT system for transporting an high perveance Xe+ beam will be presented and the results of numerical simulations will be shown.
High perveance negative ion beams with low emittance are essential for several next generation particle accelerators (i. g. spallation sources like ESS [1] and SNS [2]). The extraction and transport of these beams have intrinsic difficulties different from positive ion beams. Limitation of beam current and emittance growth have to be avoided. To fulfill the requirements of those projects a detailed knowledge of the physics of beam formation the interaction of the H- with the residual gas and transport is substantial. A compact cesium free H- volume source delivering a low energy high perveance beam (6.5 keV, 2.3 mA, perveance K= 0.0034) has been built to study the fundamental physics of beam transport and will be integrated into the existing LEBT section in the near future. First measurements of the interaction between the ion beam and the residual gas will be presented together with the experimental set up and preliminary results.
The knowledge of the build up time of space charge compensation (SCC) and the investigation of the compensation process is of main interest for low energy beam transport of pulsed high perveance ion beams under space charge compensated conditions. To investigate experimentally the rise of compensation an LEBT system consisting of a pulsed ion source, two solenoids and a drift tube as diagnostic section has been set up. The beam potential has been measured time resolved by a residual gas ion energy analyser (RGA). A numerical simulation for the calculation of self-consistent equilibrium states of the beam plasma has been developed to determine plasma parameters which are difficult measure directly. The results of the simulation has been compared with the measured data to investigate the behavior of the compensation electrons as a function of time. The acquired data shows that the theoretical rise time of space charge compensation is by a factor of two shorter than the build up time determined experimentally. In view of description the process of SCC an interpretation of the gained results is given.
The determination of the beam emittance using conventional destructive methods suffers from two main disadvantages. The interaction between the ion beam and the measurement device produces a high amount of secondary particles. Those particles interact with the beam and can change the transport properties of the accelerator. Particularly in the low energy section of high current accelerators like proposed for IFMIF, heavy ion inertial fusion devices (HIDIF) and spallation sources (ESS, SNS) the power deposited on the emittance measurement device can lead to extensive heat on the detector itself and can destruct or at least dejust the device (slit or grit for example). CCD camera measurements of the incident light emitted from interaction of beam ions with residual gas are commonly used for determination of the beam emittance. Fast data acquisition and high time resolution are additional features of such a method. Therefore a matrix formalism is used to derive the emittance from the measured profile of the beam [1,2] which does not take space charge effects and emittance growth into account. A new method to derive the phase space distribution of the beam from a single CCD camera image using statistical numerical methods will be presented together with measurements. The results will be compared with measurements gained from a conventional Allison type (slit-slit) emittance measurement device.
Hybrid robust deep and shallow semantic processing for creativity support in document production
(2004)
The research performed in the DeepThought project (http://www.project-deepthought.net) aims at demonstrating the potential of deep linguistic processing if added to existing shallow methods that ensure robustness. Classical information retrieval is extended by high precision concept indexing and relation detection. We use this approach to demonstrate the feasibility of three ambitious applications, one of which is a tool for creativity support in document production and collective brainstorming. This application is described in detail in this paper. Common to all three applications, and the basis for their development is a platform for integrated linguistic processing. This platform is based on a generic software architecture that combines multiple NLP components and on robust minimal recursive semantics (RMRS) as a uniform representation language.
Objective: Establishment of an immunocompetent mouse model representing the typical progressive stages observed in malignant human gliomas for the in vivo evaluation of novel target-specific regimens.
Methods: Isolated clones from tumours that arose spontaneously in GFAP-v-src transgenic mice were used to develop a transplantable brain tumour model in syngeneic B6C3F1 mice. STAT3 protein was knocked down by infection of tumour cells with replication-defective lentivirus encoding STAT3-siRNA. Apoptosis is designed to be induced by soluble recombinant TRAIL + chemical Bcl-2/Bcl-xL inhibitors.
Results: Striatal implantation of 105 mouse tumour cells resulted in the robust development of microscopically (2 – 3 mm) infiltrating malignant gliomas. Immunohistochemically, the gliomas displayed the astroglial marker GFAP and the oncogenic form of STAT3 (Tyr-705-phosphorylated) which is found in many malignancies including gliomas. Phosphorylated STAT3 was particularly prominent in the nucleus but was also found at the plasma membrane of peripherally infiltrating glioma cells. To evaluate the role of STAT3 in tumour progression, we stably expressed siRNA against STAT3 in several murine glioma cell lines. The effect of STAT3 depletion on proliferation, invasion and survival will be first assessed in vitro and subsequently after transplantation in vivo. Upstream and downstream components of the STAT3 signalling pathway as well as possible non-specific side effects of STAT3-siRNA expression after lentiviral infection will be examined, too.
Conclusions: Its high rate of engraftment, its similarity to the malignant glioma of origin, and its rapid locally invasive growth should make this murine model useful in testing novel therapies for malignant gliomas.