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Eine Konstante der Diskussion zur Bestimmung von "Narrativität" ist der Versuch, Narrativität als kennzeichnendes Merkmal des erzählenden Textes funktional zu bestimmen: nämlich als eine spezifische Form der symbolischen Ereignisrepräsentation. Dieser Beitrag entwickelt dagegen die These, daß Narrativität keine Frage des Entweder/Oder ist, sondern eine der graduellen Realisation spezifischer logischer Bedingungen, die sich in Form einer sog. "Ereignis-Matrix" definieren lassen. Alles, was die Bedingungen der Ereignis-Matrix erfüllt, taugt zum "Ereignis-Konstrukt" – aber nur jene Ereignis-Konstrukte und damit auch die ihnen zugrundeliegenden Texte sind in sich selbst narrativ, in denen die temporale Ordnung sich nicht auf die reine Sequentialität der symbolischen Zeichen reduziert.
A glance at the current situation in literary criticism shows that narratology, pronounced dead twenty years ago, is remarkably alive and well. This fact has been noted repeatedly and with understandable self-satisfaction in the recent literature on research into narrative theory. Just how astonishing this rebirth is, however, becomes apparent only when we step back from literary criticism and the humanities to take a wider historical view of the developments in academic and theoretical circles that preceded it. The deeply symbolic year of 1968 marked the fall of the academic ancient régime. Partly in anticipation of this and partly in response to it, a number of new leading disciplines were raised to power in western Europe as sources of hope for the future. However much they may have differed from one another in political purpose (in theoretical circles or beyond), linguistics, political economy, psychoanalysis, and structuralist semiology—to name but a few of the superdisciplines of the time—clearly belonged to one and the same paradigm in terms of how they conceived of themselves: throughout, they sought to reveal universal, ahistorical regularities in human thought and action in their respective fields.
This article combines a brief introduction into a particular philosophical theory of "time" with a demonstration of how this theory has been implemented in a Literary Studies oriented Humanities Computing project. The aim of the project was to create a model of text-based time cognition and design customized markup and text analysis tools that help to understand ‘‘how time works’’: more precisely, how narratively organised and communicated information motivates readers to generate the mental image of a chronologically organized world. The approach presented is based on the unitary model of time originally proposed by McTaggart, who distinguished between two perspectives onto time, the so-called A- and B-series. The first step towards a functional Humanities Computing implementation of this theoretical approach was the development of TempusMarker—a software tool providing automatic and semi-automatic markup routines for the tagging of temporal expressions in natural language texts. In the second step we discuss the principals underlying TempusParser—an analytical tool that can reconstruct temporal order in events by way of an algorithm-driven process of analysis and recombination of textual segments during which the "time stamp" of each segment as indicated by the temporal tags is interpreted.
Digital document and interpretation : re-thinking "text" and scholarship in electronic settings
(2008)
The contribution starts from outlining the evolution of the scholarly production flow from the print based paradigm to the digital age and in this context it explores the opposition of digital versus analog representation modes. It then develops on the triple paradigm shift caused by genuine digital publishing and its specific consequences for the social sciences and humanities (SSH) which in turn results in re-constituting basic scholarly notions such as 'text' and 'document'. The paper concludes with discussing the specific value that could be added in systematically using digital text resources as a basis for scholarly work and also states some of the necessary conditions for such a 'digital turn' to be successful in the SSH.
Objective: Excessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune responses in Parkinson disease patients are dysregulated, leading to an increased inflammatory reaction to unspecific triggers. Although α‐synuclein pathology is the hallmark of Parkinson disease, it has not been investigated whether pathologic α‐synuclein is a specific trigger for excessive inflammatory responses in Parkinson disease.
Methods: We investigated the immune response of primary human monocytes and a microglial cell line to pathologic forms of α‐synuclein by assessing cytokine release upon exposure.
Results: We show that pathologic α‐synuclein (mutations, aggregation) results in a robust inflammatory activation of human monocytes and microglial BV2 cells. The activation is conformation‐ dependent, with increasing fibrillation and early onset mutations having the strongest effect on immune activation. We also found that activation of immune cells by extracellular α‐synuclein is potentiated by extracellular vesicles, possibly by facilitating the uptake of α‐synuclein. Blood extracellular vesicles from Parkinson disease patients induce a stronger activation of monocytes than blood extracellular vesicles from healthy controls. Most importantly, monocytes from Parkinson disease patients are dysregulated and hyperactive in response to stimulation with pathologic α‐synuclein. Furthermore, we demonstrate that α‐synuclein pathology in the CNS is sufficient to induce the monocyte dysregulation in the periphery of a mouse model.
Interpretation: Taken together, our data suggest that α‐synuclein pathology and dysregulation of monocytes in Parkinson disease can act together to induce excessive inflammatory responses to α‐synuclein. ANN NEUROL 2019;86:593–606
CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhibitors of CXCR4-tropic HIV-1 strains. This approach identified a 16 amino acid fragment of serum albumin as an effective and highly specific CXCR4 antagonist. The endogenous peptide, termed EPI-X4, is evolutionarily conserved and generated from the highly abundant albumin precursor by pH-regulated proteases. EPI-X4 forms an unusual lasso-like structure and antagonizes CXCL12-induced tumor cell migration, mobilizes stem cells, and suppresses inflammatory responses in mice. Furthermore, the peptide is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker. Our results identify EPI-X4 as a key regulator of CXCR4 signaling and introduce proteolysis of an abundant precursor protein as an alternative concept for chemokine receptor regulation.
Correlations between the harmonic flow coefficients v1, v2, v3 and v4 of nucleons in semi-peripheral Au+Au collisions at a beam energy of 1.23 AGeV are investigated within the hadronic transport approach ultra-relativistic quantum molecular dynamics (UrQMD). In contrast to ultra-relativistic collision energies (where the flow coefficients are evaluated with respect to the respective event plane), we predict strong correlations between the flow harmonics with respect to the reaction plane. Based on an event-by-event selection of the midrapidity final state elliptic flow of nucleons we show that as a function of rapidity, (I) the sign of the triangular flow changes, (II) that the shape of v4 changes from convex to concave, and (III) that v3∝v1v2 and v4∝v22 for all different event classes, indicating strong correlations between all investigated harmonic flow coefficients.