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Winter, Hanna ; Winski, Greg ; Busch, Albert Franz Jakob ; Chernogubova, Ekaterina ; Fasolo, Francesca ; Wu, Zhiyuan ; Bäcklund, Alexandra ; Khomtchouk, Bohdan B. ; Van Booven, Derek J. ; Sachs, Nadja ; Eckstein, Hans-Henning ; Wittig, Ilka ; Boon, Reinier ; Jin, Hong ; Mägdefessel, Lars
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our study investigates the role of lncRNA Nudix Hydrolase 6 (NUDT6) and its antisense target fibroblast growth factor 2 (FGF2) in two vascular pathologies: abdominal aortic aneurysms (AAA) and carotid artery disease. Using tissue samples from both diseases, we detected a substantial increase of NUDT6, whereas FGF2 was downregulated. Targeting Nudt6 in vivo with antisense oligonucleotides in three murine and one porcine animal model of carotid artery disease and AAA limited disease progression. Restoration of FGF2 upon Nudt6 knockdown improved vessel wall morphology and fibrous cap stability. Overexpression of NUDT6 in vitro impaired smooth muscle cell (SMC) migration, while limiting their proliferation and augmenting apoptosis. By employing RNA pulldown followed by mass spectrometry as well as RNA immunoprecipitation, we identified Cysteine and Glycine Rich Protein 1 (CSRP1) as another direct NUDT6 interaction partner, regulating cell motility and SMC differentiation. Overall, the present study identifies NUDT6 as a well-conserved antisense transcript of FGF2. NUDT6 silencing triggers SMC survival and migration and could serve as a novel RNA-based therapeutic strategy in vascular diseases.
Giustino, Feliciano ; Lee, Jin Hong ; Trier, Felix ; Bibes, Manuel ; Winter, Stephen M. ; Valentí, Roser ; Son, Young-Woo ; Taillefer, Louis ; Heil, Christoph ; Figueroa, Adriana I. ; Plaçais, Bernard ; Wu, QuanSheng ; Yazyev, Oleg ; Bakkers, Erik P. A. M. ; Nygård, Jesper ; Forn-Díaz, Pol ; De Franceschi, Silvano ; McIver, James W. ; Foa Torres, Luis E. F. ; Low, Tony ; Kumar, Anshuman ; Galceran, Regina ; Valenzuela, Sergio O. ; Costache, Marius V. ; Manchon, Aurélien ; Kim, Eun-Ah ; Schleder, Gabriel R. ; Fazzio, Adalberto ; Roche, Stephan
In recent years, the notion of 'Quantum Materials' has emerged as a powerful unifying concept across diverse fields of science and engineering, from condensed-matter and coldatom physics to materials science and quantum computing. Beyond traditional quantum materials such as unconventional superconductors, heavy fermions, and multiferroics, the field has significantly expanded to encompass topological quantum matter, two-dimensional materials and their van der Waals heterostructures, Moiré materials, Floquet time crystals, as well as materials and devices for quantum computation with Majorana fermions. In this Roadmap collection we aim to capture a snapshot of the most recent developments in the field, and to identify outstanding challenges and emerging opportunities. The format of the Roadmap, whereby experts in each discipline share their viewpoint and articulate their vision for quantum materials, reflects the dynamic and multifaceted nature of this research area, and is meant to encourage exchanges and discussions across traditional disciplinary boundaries. It is our hope that this collective vision will contribute to sparking new fascinating questions and activities at the intersection of materials science, condensed matter physics, device engineering, and quantum information, and to shaping a clearer landscape of quantum materials science as a new frontier of interdisciplinary scientific inquiry. We stress that this article is not meant to be a fully comprehensive review but rather an up-to-date snapshot of different areas of research on quantum materials with a minimal number of references focusing on the latest developments.
Abelev, Betty ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Bai, Y. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Baumgart, S. ; Beavis, D.R. ; Bellwied, Rene ; Benedosso, F. ; Betancourt, M.J. ; Betts, R.R. ; Bharadwaj, Somnath ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biritz, B. ; Bland, Leslie C. ; Bombara, Marek ; Bonner, B.E. ; Botje, Michiel ; Bouchet, J. ; Braidot, E. ; Brandin, Andrei V. ; Bruna, Elena ; Bueltmann, S. ; Burton, T.P. ; Bystersky, M. ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Callner, J. ; Catu, O. ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M.C. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H.F. ; Chen, J.H. ; Chen, J.Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, K.E. ; Christie, William ; Chung, Suh-Urk ; Clarke, R.F. ; Codrington, M.J. ; Coffin, Jean Pierre ; Corliss, R. ; Cormier, Thomas Michael ; Cosentino, Mauro Rogerio ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Dash, Sadhana ; Daugherity, M. ; De Silva, C. ; Dedovič, Tatiana G. ; DePhillips, M. ; Derevschikov, Anatoly A. ; Souza, Rafael Derradi de ; Didenko, Lidia ; Djawotho, P. ; Dogra, Sunil Manohar ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Du, F. ; Dunlop, James C. ; Dutta Mazumdar, M.R. ; Edwards, W.R. ; Efimov, Leonid G. ; Elhalhuli, E. ; Elnimr, M. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Eun, L. ; Fachini, Patricia ; Fatemi, Renee H. ; Fedorišin, Jan ; Feng, A. ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gaillard, L. ; Gangadharan, Dhevan Raja ; Ganti, Murthy S. ; Garcia-Solis, Edmundo Javier ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gorbunov, Y.N. ; Gordon, A. ; Grebenyuk, Oleksandr ; Grosnick, David P. ; Grube, B. ; Guertin, Steven M. ; Guimaraes, K.S.F.F. ; Gupta, Anik ; Gupta, N. ; Guryn, Włodzimierz ; Haag, B. ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Harris, John W. ; He, W. ; Heinz, Mark Thomas ; Hepplemann, S. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffman, A.M. ; Hoffmann, Gerald W. ; Hofman, D.J. ; Hollis, R.S. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Igo, George J. ; Iordanova, A. ; Jacobs, P. ; Jacobs, William W. ; Jakl, P. ; Jin, F. ; Jones, C.L. ; Jones, Peter Graham ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kajimoto, K. ; Kang, K. ; Kapitan, J. ; Kaplan, Morton ; Keane, Declan ; Kechechyan, Armen ; Kettler, D. ; Khodyrev, V.Yu. ; Kikola, D.P. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klein, Spencer Robert ; Knospe, Anders Garritt ; Kocoloski, A. ; Koetke, Donald D. ; Kopytine, M. ; Kotchenda, L. ; Kouchpil, V. ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Krus, M. ; Kuhn, Christian Claude ; Kumar, Lokesh ; Kurnadi, P. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; LaPointe, S. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, C.-H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, Y. ; Lin, G. ; Lin, X. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, J. ; Liu, L. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Love, William A. ; Lu, Y. ; Ludlam, Thomas ; Lynn, David ; Ma, G.L. ; Ma, Yu-Gang ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mall, O.I. ; Mangotra, L.K. ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matulenko, Yu.A. ; McShane, Tom S. ; Meščanin, Aleksei P. ; Millner, R. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mischke, André ; Mitchell, J. ; Mohanty, Bedangadas ; Morozov, Dmitry A. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nattrass, Christine ; Nayak, Tapan Kumar ; Nelson, John M. ; Nepali, C. ; Netrakanti, Pawan Kumar ; Ng, M.J. ; Nogach, Larisa V. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okada, H. ; Okorokov, Vitaly A. ; Olson, Douglas L. ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Phatak, S.C. ; Planinic, Mirko ; Pluta, Jan Marian ; Poljak, Nikola ; Poskanzer, Arthur M. ; Potukuchi, B.V.K.S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Redwine, R. ; Reed, Rosi Jan ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, L. ; Russcher, M.J. ; Rykov, Vladimir L. ; Sahoo, Raghunath ; Sakrejda, Iwona ; Sakuma, T. ; Salur, Sevil ; Sandweiss, Jack H. ; Sarsour, M. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Seger, Janet Elizabeth ; Selyuzhenkov, Ilya ; Seyboth, Peter ; Shabetai, Alexandre ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, M. ; Shi, Shusu ; Shi, X.-H. ; Sichtermann, Ernst P. ; Simon, F. ; Singaraju, Rama Narayana ; Skoby, Michael J. ; Smirnov, Nikolai ; Snellings, Raimond ; Sorensen, Paul Richard ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, B. ; Stadnik, A. ; Stanislaus, T. D. Shirvel ; Staszak, D. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Suarez, M.C. ; Subba, N.L. ; Šumbera, Michal ; Sun, X.M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Tian, J. ; Timmins, Anthony Robert ; Timoshenko, Sergei ; Tlusty, David ; Tokarev, Mikhail V. ; Trainor, T.A. ; Tram, V.N. ; Trattner, A.L. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ulery, Jason Glyndwr ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Leeuwen, Marco van ; Vander Molen, A.M. ; Vanfossen, J.A. ; Varma, Raghava ; Vasconcelos, G.M.S. ; Vasilevski, I.M. ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Wada, M. ; Waggoner, William T. ; Walker, M. ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, Q. ; Wang, X. ; Wang, X.L. ; Wang, Y. ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Yepes, Pablo P. ; Yoo, In-Kwon ; Yue, Q. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhan, W. ; Zhang, H. ; Zhang, S. ; Zhang, W.M. ; Zhang, Y. ; Zhang, Z.P. ; Zhao, Y. ; Zhong, C. ; Zhou, J. ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zuo, J.X.
We study the beam-energy and system-size dependence of \phi meson production (using the hadronic decay mode \phi -- K+K-) by comparing the new results from Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4 and 200 GeV measured in the STAR experiment at RHIC. Data presented are from mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the transverse momentum distributions for \phi mesons are observed to be similar in yield and shape for Cu+Cu and Au+Au colliding systems with similar average numbers of participating nucleons. The \phi meson yields in nucleus-nucleus collisions, normalised by the average number of participating nucleons, are found to be enhanced relative to those from p+p collisions with a different trend compared to strange baryons. The enhancement for \phi mesons is observed to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision energies, the source of enhancement of strange hadrons is related to the formation of a dense partonic medium in high energy nucleus-nucleus collisions and cannot be alone due to canonical suppression of their production in smaller systems.
Abelev, Betty ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Baumgart, S. ; Beavis, D. R. ; Bellwied, Rene ; Benedosso, F. ; Betancourt, M. J. ; Betts, R. R. ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biritz, B. ; Bland, Leslie C. ; Bombara, Marek ; Bonner, Billy E. ; Botje, Michiel ; Bouchet, J. ; Braidot, E. ; Brandin, Andrei V. ; Bruna, Elena ; Bueltmann, S. ; Burton, T. P. ; Bystersky, M. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Catu, O. ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M. C. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, J. H. ; Chen, J. Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, K. E. ; Christie, William ; Clarke, R. F. ; Codrington, M. J. M. ; Corliss, R. ; Cormier, Thomas Michael ; Cosentino, Mauro Rogerio ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Dash, Sadhana ; Daugherity, M. ; Silva, L. C. De ; Dedovich, T. G. ; DePhillips, M. ; Derevschikov, Anatoly A. ; de Souza, R. Derradi ; Didenko, Lidia ; Djawotho, P. ; Dogra, Sunil Manohar ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Dunlop, James C. ; Mazumdar, M. R. Dutta ; Edwards, W. R. ; Efimov, Leonid G. ; Elhalhuli, E. ; Elnimr, M. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Eun, L. ; Fachini, Patricia ; Fatemi, Renee H. ; Fedorišin, Jan ; Feng, A. ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gaillard, L. ; Gangadharan, Dhevan Raja ; Ganti, Murthy S. ; Garcia-Solis, E. J. ; Geromitsos, A. ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gorbunov, Y. N. ; Gordon, A. ; Grebenyuk, Oleksandr ; Grosnick, David P. ; Grube, B. ; Guertin, Steven M. ; Guimaraes, K. S. F. F. ; Gupta, Anik ; Gupta, N. ; Guryn, Włodzimierz ; Haag, B. ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Harris, John W. ; He, W. ; Heinz, Mark Thomas ; Heppelmann, S. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffman, A. M. ; Hoffmann, Gerald W. ; Hofman, D. J. ; Hollis, R. S. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Huo, L. ; Igo, George J. ; Iordanova, A. ; Jacobs, P. ; Jacobs, William W. ; Jakl, P. ; Jena, Chitrasen ; Jin, F. ; Jones, C. L. ; Jones, Peter Graham ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kajimoto, K. ; Kang, K. ; Kapitan, J. ; Keane, Declan ; Kechechyan, Armen ; Kettler, D. ; Khodyrev, V. Yu. ; Kikola, D. 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The STAR Collaboration at the Relativistic Heavy Ion Collider presents measurements of 𝐽/𝜓→𝑒+𝑒− at midrapidity and high transverse momentum (𝑝𝑇>5 GeV/𝑐) in 𝑝+𝑝 and central Cu+Cu collisions at √𝑠𝑁𝑁=200 GeV. The inclusive 𝐽/𝜓 production cross section for Cu+Cu collisions is found to be consistent at high 𝑝𝑇 with the binary collision-scaled cross section for 𝑝+𝑝 collisions. At a confidence level of 97%, this is in contrast to a suppression of 𝐽/𝜓 production observed at lower 𝑝𝑇. Azimuthal correlations of 𝐽/𝜓 with charged hadrons in 𝑝+𝑝 collisions provide an estimate of the contribution of 𝐵-hadron decays to 𝐽/𝜓 production of 13%±5%.