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We compute the vacuum polarization correction to the binding energy of nuclear matter in the Walecka model using a nonperturbative approach. We first study such a contribution as arising from a ground-state structure with baryon-antibaryon condensates. This yields the same results as obtained through the relativistic Hartree approximation of summing tadpole diagrams for the baryon propagator. Such a vacuum is then generalized to include quantum effects from meson fields through scalar-meson condensates which amounts to summing over a class of multiloop diagrams. The method is applied to study properties of nuclear matter and leads to a softer equation of state giving a lower value of the incompressibility than would be reached without quantum effects. The density-dependent effective sigma mass is also calculated including such vacuum polarization effects.