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Adams, John ; Adler, Clemens ; Ahammed, Zubayer ; Allgower, Chris ; Amonett, John ; Anderson, Bryon D. ; Anderson, Mike ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cardenas, Alex ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Castro, M. ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, Yu ; Chernenko, S. P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, Bum ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Corral, M. Mora ; Cramer, John G. ; Crawford, Henry J. ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Draper, James E. ; Dunin, V. B. ; Dunlop, James C. ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Fachini, Patricia ; Faine, V. ; Faivre, Julien ; Fatemi, Renee H. ; Filimonov, Kirill ; Finch, Evan ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fu, Jinghua ; Gagliardi, Carl A. ; Gagunashvili, N. ; Gans, Jon ; Gaudichet, Ludovic ; Germain, Marie ; Geurts, Frank ; Ghazikhanian, Vahe ; Grachov, Oleg A. ; Guedon, M. ; Guertin, Steven M. ; Gushin, E. ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark ; Henry, Thomas W. ; Heppelmann, Steven Francis ; Herston, Timothy ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, Matthew ; Huang, Huan Zhong ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, Aya ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Johnson, Ian ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kaneta, Kaneta ; Kaplan, Morton ; Keane, Declan ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Kollegger, Thorsten ; Konstantinov, A. S. ; Kopytine, M. ; Kotchenda, L. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, Curtis Patrick Leon ; Lasiuk, Brian ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednický, Richard ; Leontiev, V. M. ; LeVine, Micheal J. ; Li, Q. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, Feng ; Liu, L. ; Liu, Zhixu ; Liu, Q. J. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, Hui ; Longacre, Ronald S. ; Lopez-Noriega, Mercedes ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, Jingguo ; Ma, Yu-Gang ; Magestro, Daniel ; Majka, Richard Daniel ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Messer, Matthias ; Miller, Michael L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mitchell, J. ; Molnar, Levente ; Moore, C. F. ; Morozov, Vladimir ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Nelson, John M. ; Nevski, P. ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, Ben ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Paic, Guy ; Pandey, S. U. ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Perevoztchikov, V. ; Peryt, Wiktor Stanislaw ; Petrov, V. A ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potrebenikova, E. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, Gael ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogachevski, O. V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Rykov, Vladimir L. ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shestermanov, Konstantin E. ; Shimanskii, S. S. ; Simon, Frank ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sorensen, Paul ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stephenson, Edward J. ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Thein, Dylan ; Thomas, James H. ; Thompson, M. ; Timoshenko, Sergei ; Tokarev, Mikhail V. ; Tonjes, Marguerite B. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Trofimov, V. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Vander Molen, A. M. ; Vasiliev, Alexander Nikolaevich ; Vigdor, Steven E. ; Voloshin, Sergei ; Vznuzdaev, Marat ; Wang, F. ; Wang, Yiqun ; Ward, H. ; Watson, J. W. ; Wells, Randy ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wissink, Scott W. ; Witt, Richard ; Wood, Jeff ; Xu, N. ; Xu, Zhangbu ; Yakutin, A. E. ; Yamamoto, Eugene ; Yang, J. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevski, Y. V. ; Zborovský, I. ; Zhang, Haitao ; Zhang, W. M. ; Zoulkarneev, R. ; Zoulkarneeva, J. ; Zubarev, A. N.
Data from the first physics run at the Relativistic Heavy-Ion Collider at Brookhaven National Laboratory, Au+Au collisions at sqrt[sNN]=130 GeV, have been analyzed by the STAR Collaboration using three-pion correlations with charged pions to study whether pions are emitted independently at freeze-out. We have made a high-statistics measurement of the three-pion correlation function and calculated the normalized three-particle correlator to obtain a quantitative measurement of the degree of chaoticity of the pion source. It is found that the degree of chaoticity seems to increase with increasing particle multiplicity.
Belkum, Alex van ; Almeida, Carina ; Bardiaux, Benjamin ; Barrass, Sarah V. ; Butcher, Sarah J. ; Çaykara, Tuğçe ; Chowdhury, Sounak ; Datar, Rucha ; Eastwood, Ian ; Goldman, Adrian ; Goyal, Manisha ; Happonen, Lotta ; Izadi-Pruneyre, Nadia ; Jacobsen, Theis ; Johnson, Pirjo H. ; Kempf, Volkhard A. J. ; Kießling, Andreas ; Bueno, Juan Leva ; Malik, Anchal ; Malmström, Johan ; Meuskens, Ina ; Milner, Paul A. ; Nilges, Michael ; Pamme, Nicole ; Peyman, Sally A. ; Rodrigues, Ligia R. ; Rodriguez-Mateos, Pablo ; Sande, Maria G. ; Silva, Carla Joana ; Stasiak, Aleksandra Cecylia ; Stehle, Thilo ; Thibau, Arno ; Vaca Llerena, Diana Jaqueline ; Linke, Dirk
Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen–surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin–ligand interaction, supported by present high-throughput “omics” technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.
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