Refine
Year of publication
Has Fulltext
- yes (1024)
Is part of the Bibliography
- no (1024)
Keywords
- Heavy Ion Experiments (20)
- Hadron-Hadron scattering (experiments) (11)
- Hadron-Hadron Scattering (9)
- Heavy-ion collision (6)
- breast cancer (5)
- LHC (4)
- Quark-Gluon Plasma (4)
- diagnosis (4)
- ALICE experiment (3)
- Collective Flow (3)
Institute
- Physik (1014)
- Frankfurt Institute for Advanced Studies (FIAS) (918)
- Informatik (884)
- Medizin (8)
- Informatik und Mathematik (3)
- Hochschulrechenzentrum (2)
- Biodiversität und Klima Forschungszentrum (BiK-F) (1)
- Biowissenschaften (1)
- Institut für Ökologie, Evolution und Diversität (1)
- Senckenbergische Naturforschende Gesellschaft (1)
Inclusive, prompt and non-prompt J/ψ production at midrapidity in p−Pb collisions at √sNN = 5.02 TeV
(2022)
A measurement of inclusive, prompt, and non-prompt J/ψ production in p−Pb collisions at a nucleon−nucleon centre-of-mass energy sNN−−−√=5.02 TeV is presented. The inclusive J/ψ mesons are reconstructed in the dielectron decay channel at midrapidity down to a transverse momentum pT=0. The inclusive J/ψ nuclear modification factor RpPb is calculated by comparing the new results in p−Pb collisions to a recently measured proton−proton reference at the same centre-of-mass energy. Non-prompt J/ψ mesons, which originate from the decay of beauty hadrons, are separated from promptly produced J/ψ on a statistical basis for pT larger than 1.0 GeV/c. These results are based on the data sample collected by the ALICE detector during the 2016 LHC p−Pb run, corresponding to an integrated luminosity Lint=292±11μb−1, which is six times larger than the previous publications. The total uncertainty on the pT-integrated inclusive J/ψ and non-prompt J/ψ cross section are reduced by a factor 1.7 and 2.2, respectively. The measured cross sections and RpPb are compared with theoretical models that include various combinations of cold nuclear matter effects. From the non-prompt J/ψ production cross section, the bb¯¯¯ production cross section at midrapidity, dσbb¯¯¯/dy, and the total cross section extrapolated over full phase space, σbb¯¯¯, are derived.
Annihilation dynamics plays a fundamental role in the baryon−antibaryon interaction (B−B¯¯¯¯) at low-energy and its strength and range are crucial in the assessment of possible baryon bound states. Experimental data on annihilation cross sections are available for the p−p¯¯¯ system but not in the low relative momentum region. Data regarding the BB¯¯¯¯ interaction with strange degrees of freedom are extremely scarce or absent, hence the modeling of the annihilation contributions is mainly based on nucleon−antinucleon (N−N¯¯¯¯) results, when available. In this letter we present a measurement of the p−p¯¯¯, p−Λ¯¯¯¯⊕p¯¯¯−Λ and Λ−Λ¯¯¯¯ interaction using correlation functions in the relative momentum space in high-multiplicity triggered pp collisions at s√=13 TeV recorded by ALICE at the LHC. In the p−p¯¯¯ system the couplings to the mesonic channels in different partial waves are extracted by adopting a coupled-channel approach with recent χEFT potentials. The inclusion of these inelastic channels provides good agreement with the data, showing a significant presence of the annihilation term down to zero momentum. Predictions obtained using the Lednický−Lyuboshits formula and scattering parameters obtained from heavy-ion collisions, hence mainly sensitive to elastic processes, are compared with the experimental p−Λ¯¯¯¯⊕p¯¯¯−Λ and Λ−Λ¯¯¯¯ correlations. The model describes the Λ−Λ¯¯¯¯ data and underestimates the p−Λ¯¯¯¯⊕p¯¯¯−Λ data in the region of momenta below 200 MeV/c. The observed deviation indicates a different contribution of annihilation channels to the two systems containing strange hadrons.
Annihilation dynamics plays a fundamental role in the baryon−antibaryon interaction (B−B¯¯¯¯) at low-energy and its strength and range are crucial in the assessment of possible baryon bound states. Experimental data on annihilation cross sections are available for the p−p¯¯¯ system but not in the low relative momentum region. Data regarding the BB¯¯¯¯ interaction with strange degrees of freedom are extremely scarce or absent, hence the modeling of the annihilation contributions is mainly based on nucleon−antinucleon (N−N¯¯¯¯) results, when available. In this letter we present a measurement of the p−p¯¯¯, p−Λ¯¯¯¯⊕p¯¯¯−Λ and Λ−Λ¯¯¯¯ interaction using correlation functions in the relative momentum space in high-multiplicity triggered pp collisions at s√=13 TeV recorded by ALICE at the LHC. In the p−p¯¯¯ system the couplings to the mesonic channels in different partial waves are extracted by adopting a coupled-channel approach with recent χEFT potentials. The inclusion of these inelastic channels provides good agreement with the data, showing a significant presence of the annihilation term down to zero momentum. Predictions obtained using the Lednický−Lyuboshits formula and scattering parameters obtained from heavy-ion collisions, hence mainly sensitive to elastic processes, are compared with the experimental p−Λ¯¯¯¯⊕p¯¯¯−Λ and Λ−Λ¯¯¯¯ correlations. The model describes the Λ−Λ¯¯¯¯ data and underestimates the p−Λ¯¯¯¯⊕p¯¯¯−Λ data in the region of momenta below 200 MeV/c. The observed deviation indicates a different contribution of annihilation channels to the two systems containing strange hadrons.
Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. These highly electrophilic fatty acids can undergo Michael addition reaction with cysteine residues, leading to post-translational modifications (PTM) of selected regulatory proteins. Such modifications are capable of changing target protein function during cell signaling or in biosynthetic pathways. NFA target proteins include the peroxisome proliferator-activated receptor γ (PPAR-γ), the pro-inflammatory and tumorigenic nuclear factor-κB (NF-κB) signaling pathway, the pro-inflammatory 5-lipoxygenases (5-LO) biosynthesis pathway as well as soluble epoxide hydrolase (sEH), which is essentially involved in the regulation of vascular tone. In several animal models of inflammation and cancer, the therapeutic efficacy of well-tolerated NFA has been demonstrated. This has already led to clinical phase II studies investigating possible therapeutic effects of NFA in subjects with pulmonary arterial hypertension. Albeit Michael acceptors feature a broad spectrum of bioactivity, they have for a rather long time been avoided as drug candidates owing to their presumed unselective reactivity and toxicity. However, targeted covalent modification of regulatory proteins by Michael acceptors became recognized as a promising approach to drug discovery with the recent FDA approvals of the cancer therapeutics, afatanib (2013), ibrutinib (2013), and osimertinib (2015). Furthermore, the Michael acceptor, neratinib, a dual inhibitor of the human epidermal growth factor receptor 2 and epidermal growth factor receptor, was recently approved by the FDA (2017) and by the EMA (2018) for the treatment of breast cancer. Finally, a number of further Michael acceptor drug candidates are currently under clinical investigation for pharmacotherapy of inflammation and cancer. In this review, we focus on the pharmacology of NFA and other Michael acceptor drugs, summarizing their potential as an emerging class of future antiphlogistics and adjuvant in tumor therapeutics.