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Year of publication
Language
- English (350)
Has Fulltext
- yes (350)
Is part of the Bibliography
- no (350)
Keywords
- BESIII (19)
- e +-e − Experiments (16)
- Branching fraction (12)
- Particle and Resonance Production (8)
- Charm Physics (6)
- Quarkonium (6)
- Spectroscopy (6)
- Hadronic decays (5)
- Branching fractions (4)
- Charmonium (4)
Institute
- Physik (342)
- Medizin (3)
- Biochemie und Chemie (1)
- Georg-Speyer-Haus (1)
Ablikim, Medina ; Achasov, Mikhail N. ; Ahmed, Samer ; Albrecht, Malte ; Alekseev, M. ; Amoroso, Antonio ; An, Fenfen ; An, Qi ; Bai, Y. ; Bakina, Olga ; Baldini Ferroli, Rinaldo ; Ban, Yong ; Begzsuren, Khurelbaatar ; Bennett, D. W. ; Bennett, Jake V. ; Berger, Niklaus ; Bertani, Monica ; Bettoni, Diego ; Bianchi, Fabrizio ; Boyko, Igor R. ; Briere, Roy A. ; Cai, H. ; Cai, Xiao ; Cakir, O. ; Calcaterra, Alessandro ; Cao, G. F. ; Çetin, Serkant Ali ; Chai, J. ; Chang, Jinfan ; Chang, W. L. ; Chelkov, Gueorgui A. ; Chen, G. ; Chen, Hesheng ; Chen, J. C. ; Chen, M. L. ; Chen, P. L. ; Chen, S. J. ; Chen, Yuanbo ; Cibinetto, Gianluigi ; Cossio, Fabio ; Dai, Hongliang ; Dai, J. P. ; Dbeyssi, Alaa ; Dedovich, Dmitri V. ; Deng, Ziyan ; Denig, Achim ; Denysenko, Igor ; Destefanis, Marco Giovanni Maria ; De Mori, Francesca ; Ding, Y. ; Dong, C. ; Dong, J. ; Dong, Liaoyuan ; Dong, Mingyi ; Dou, Z. L. ; Du, Shuxian ; Duan, P. F. ; Fan, J. Z. ; Fang, J. ; Fang, Shuangshi ; Fang, Y. ; Farinelli, Riccardo ; Fava, Luciano ; Fegan, S. ; Feldbauer, Florian ; Felici, Giulietto ; Feng, C. Q. ; Fritsch, Miriam ; Fu, Chengdong ; Fu, Ying ; Gao, Q. ; Gao, X. L. ; Gao, Y. ; Gao, Y. G. ; Gao, Z. ; Garillon, B. ; Garzia, I. ; Gilman, Alexander ; Goetzen, Klaus ; Gong, L. ; Gong, Wenxuan ; Gradl, Wolfgang ; Greco, M. ; Gu, L. M. ; Gu, Minhao ; Gu, Y. T. ; Guo, Aiqiang ; Guo, L. B. ; Guo, R. P. ; Guo, Yuping ; Guskov, Alexey ; Haddadi, Z. ; Han, S. ; Hao, Xiqing ; Harris, F. A. ; He, K. L. ; Heinsius, Fritz-Herbert ; Held, T. ; Heng, Yuekun ; Holtmann, Tobias ; Hou, Zhilong ; Hu, Haiming ; Hu, J. F. ; Hu, T. ; Hu, Y. ; Huang, G. S. ; Huang, J. S. ; Huang, X. T. ; Huang, X. Z. ; Huang, Z. L. ; Hussain, Tahir ; Ikegami Andersson, Walter ; Irshad, M. ; Ji, Quan ; Ji, Qingping ; Ji, X. B. ; Ji, X. L. ; Jiang, Xiaoshan ; Jiang, X. Y. ; Jiao, J. B. ; Jiao, Z. ; Jin, D. P. ; Jin, Shan ; Jin, Y. ; Johansson, Tord ; Julin, A. ; Kalantar-Nayestanaki, Nasser ; Kang, X. S. ; Kavatsyuk, Myroslav O. ; Ke, Bai-Cian ; Khan, T. ; Khoukaz, Alfons ; Kiese, P. ; Kliemt, Ralf ; Koch, Leonard ; Kolcu, Onur Bugra ; Kopf, Bertram ; Kornicer, M. ; Kuemmel, M. ; Küßner, Meike ; Kupsc, Andrzej ; Kurth, M. ; Kühn, Wolfgang ; Lange, Jens Sören ; Lara, M. ; Larin, Paul ; Lavezzi, Lia ; Leiber, S. ; Leithoff, H. ; Li, C. ; Li, Cheng ; Li, D. M. ; Li, F. ; Li, F. Y. ; Li, G. ; Li, Haibo ; Li, Huijing ; Li, J. C. ; Li, J. W. ; Li, Ke ; Li, Lei ; Li, P. L. ; Li, Peirong ; Li, Q. Y. ; Li, T. ; Li, Weidong ; Li, Weiguo ; Li, X. L. ; Li, X. N. ; Li, X. Q. ; Li, Z. B. ; Liang, H. ; Liang, Y. F. ; Liang, Y. T. ; Liao, G. R. ; Liao, L. Z. ; Libby, J. ; Lin, C. X. ; Lin, D. X. ; Liu, B. ; Liu, B. J. ; Liu, C. X. ; Liu, D. ; Liu, D. Y. ; Liu, Fu-Hu ; Liu, Fang ; Liu, Feng ; Liu, H. B. ; Liu, H. L. ; Liu, H. M. ; Liu, Huanhuan ; Liu, Huihui ; Liu, J. B. ; Liu, J. Y. ; Liu, K. ; Liu, K. Y. ; Liu, Ke ; Liu, Q. ; Liu, S. B. ; Liu, X. ; Liu, Y. B. ; Liu, Zhen-An ; Liu, Zhiqing ; Long, Y. F. ; Lou, Xinchou ; Lu, H. J. ; Lu, J. D. ; Lu, Junguang ; Lu, Y. ; Lu, Yunpeng ; Luo, Chenglin ; Luo, M. X. ; Luo, X. L. ; Lusso, S. ; Lyu, Xiao-Rui ; Ma, Fengcai ; Ma, Hailong ; Ma, Lianliang ; Ma, M. M. ; Ma, Qiumei ; Ma, X. N. ; Ma, X. X. ; Ma, Xiaoyan ; Ma, Y. M. ; Maas, Frank E. ; Maggiora, Marco ; Malik, Qadeer Afzal ; Mangoni, Alessio ; Mao, Yajun ; Mao, Zepu ; Marcello, Simonetta ; Meng, Z. X. ; Messchendorp, Johannes Gerhardus ; Mezzadri, Giulio ; Min, J. ; Min, T. J. ; Mitchell, Ryan Edward ; Mo, Xiaohu ; Mo, Y. J. ; Morales, C. Morales ; Morello, G. ; Muchnoi, Nikolai Yu. ; Muramatsu, H. ; Mustafa, A. ; Nakhoul, Simon ; Nefedov, Yury ; Nerling, Frank ; Nikolaev, Ivan Borisovich ; Ning, Z. ; Nisar, Shabana ; Niu, S. L. ; Olsen, Stephen L. ; Ouyang, Qun ; Pacetti, Simone ; Pan, Y. ; Papenbrock, M. ; Patteri, P. ; Pelizäus, Marc ; Pellegrino, J. ; Peng, H. P. ; Peters, Klaus ; Pettersson, J. ; Ping, J. L. ; Ping, R. G. ; Pitka, A. ; Poling, Ronald ; Prasad, Vindhyawasini ; Qi, H. R. ; Qi, Ming ; Qi, T. Y. ; Qian, S. ; Qiao, Congfeng ; Qin, N. ; Qin, X. S. ; Qin, Zhonghua ; Qiu, Jinfa ; Rashid, K. H. ; Redmer, Christoph Florian ; Richter, M. ; Ripka, M. ; Da Rocha Rolo, Manuel Dionisio ; Rong, Gang ; Rosner, Christoph ; Sarantsev, Andrei V. ; Savrié, M. ; Schnier, Claudius ; Schönning, Karin ; Shan, Wei ; Shan, Xinyu ; Shao, M. ; Shen, C. P. ; Shen, P. X. ; Shen, X. Y. ; Sheng, H. Y. ; Shi, X. ; Song, J. J. ; Song, W. M. ; Song, X. Y. ; Sosio, Stefano ; Sowa, C. ; Spataro, Stefano ; Sun, Gongxing ; Sun, J. F. ; Sun, L. ; Sun, S. S. ; Sun, X. H. ; Sun, Y. J. ; Sun, Y. K. ; Sun, Y. Z. ; Sun, Z. J. ; Sun, Z. T. ; Tan, Y. T. ; Tang, C. J. ; Tang, G. Y. ; Tang, X. ; Tapan, I. ; Tiemens, M. ; Tsednee, B. ; Uman, Ismail ; Varner, G. S. ; Wang, B. ; Wang, B. L. ; Wang, C. W. ; Wang, D. Y. ; Wang, Dan ; Wang, K. ; Wang, L. L. ; Wang, L. S. ; Wang, M. ; Wang, Meng ; Wang, P. ; Wang, P. L. ; Wang, W. P. ; Wang, Xiongfei ; Wang, Y. ; Wang, Y. F. ; Wang, Y. Q. ; Wang, Z. ; Wang, Z. G. ; Wang, Z. Y. ; Wang, Zongyuan ; Weber, T. ; Wei, D. H. ; Weidenkaff, P. ; Wen, Shuopin ; Wiedner, Ulrich ; Wolke, Magnus ; Wu, Linghui ; Wu, Lianjin ; Wu, Z. ; Xia, L. ; Xia, X. ; Xia, Y. ; Xiao, D. ; Xiao, Y. J. ; Xiao, Zhenjun ; Xie, Y. G. ; Xie, Y. H. ; Xiong, X. A. ; Xiu, Q. L. ; Xu, Guofa ; Xu, J. J. ; Xu, L. ; Xu, Q. J. ; Xu, Q. N. ; Xu, Xinping ; Yan, F. ; Yan, Liang ; Yan, W. B. ; Yan, W. C. ; Yan, Y. H. ; Yang, H. J. ; Yang, Hongxun ; Yang, L. ; Yang, S. L. ; Yang, Y. H. ; Yang, Yongxu ; Yang, Yifan ; Ye, M. ; Ye, Minghan ; Yin, J. H. ; You, Z. Y. ; Yu, Boxiang ; Yu, C. X. ; Yuan, Chang-Zheng ; Yuan, Y. ; Yuncu, A. ; Zafar, A. A. ; Zallo, A. ; Zeng, Y. ; Zeng, Z. ; Zhang, B. X. ; Zhang, B. Y. ; Zhang, C. C. ; Zhang, D. H. ; Zhang, H. H. ; Zhang, Hongyu ; Zhang, J. ; Zhang, J. L. ; Zhang, J. Q. ; Zhang, J. W. ; Zhang, Jianyong ; Zhang, J. Z. ; Zhang, K. ; Zhang, L. ; Zhang, S. F. ; Zhang, T. J. ; Zhang, X. Y. ; Zhang, Y. ; Zhang, Y. H. ; Zhang, Yateng ; Zhang, Yang ; Zhang, Yao ; Zhang, Yu ; Zhang, Z. H. ; Zhang, Z. P. ; Zhang, Z. Y. ; Zhao, G. ; Zhao, J. W. ; Zhao, J. Y. ; Zhao, J. Z. ; Zhao, Lei ; Zhao, Ling ; Zhao, Ming-Gang ; Zhao, Q. ; Zhao, Shujun ; Zhao, T. C. ; Zhao, Yubin ; Zhao, Zhengguo ; Zhemchugov, Alexey ; Zheng, Bo ; Zheng, Jianping ; Zheng, W. J. ; Zheng, Y. H. ; Zhong, B. ; Zhou, L. ; Zhou, Q. ; Zhou, X. ; Zhou, X. K. ; Zhou, X. R. ; Zhou, X. Y. ; Zhu, A. N. ; Zhu, J. ; Zhu, J. ; Zhu, K. ; Zhu, Kejun ; Zhu, S. ; Zhu, S. H. ; Zhu, X. L. ; Zhu, Y. C. ; Zhu, Y. S. ; Zhu, Zian ; Zhuang, J. ; Zou, B. S. ; Zou, Jiaheng
Using a 3.19 fb−1 data sample collected at an 𝑒+𝑒− center-of-mass energy of 𝐸cm=4.178 GeV with the BESIII detector, we measure the branching fraction of the leptonic decay 𝐷+𝑠→𝜇+𝜈𝜇 to be ℬ𝐷+𝑠→𝜇+𝜈𝜇=(5.49±0.16stat±0.15syst)×10−3. Combining our branching fraction with the masses of the 𝐷+𝑠 and 𝜇+ and the lifetime of the 𝐷+𝑠, we determine 𝑓𝐷+𝑠|𝑉𝑐𝑠|=246.2±3.6stat±3.5syst MeV. Using the 𝑐→𝑠 quark mixing matrix element |𝑉𝑐𝑠| determined from a global standard model fit, we evaluate the 𝐷+𝑠 decay constant 𝑓𝐷+𝑠=252.9±3.7stat±3.6syst MeV. Alternatively, using the value of 𝑓𝐷+𝑠 calculated by lattice quantum chromodynamics, we find |𝑉𝑐𝑠|=0.985±0.014stat±0.014syst. These values of ℬ𝐷+𝑠→𝜇+𝜈𝜇, 𝑓𝐷+𝑠|𝑉𝑐𝑠|, 𝑓𝐷+𝑠 and |𝑉𝑐𝑠| are each the most precise results to date.
Measurement of the e+e−→π+π− cross section between 600 and 900 MeV using initial state radiation
(2016)
Ablikim, Medina ; Achasov, Mikhail N. ; Ai, X.C. ; Albayrak, O. ; Albrecht, Malte ; Ambrose, D.J. ; Amoroso, Antonio ; An, Fenfen ; An, Qi ; Bai, Jingzhi ; Baldini Ferroli, Rinaldo ; Ban, Yong ; Bennett, D.W. ; Bennett, Jake V. ; Bertani, Monica ; Bettoni, Diego ; Bian, J.M. ; Bianchi, Fabrizio ; Boger, E. ; Boyko, Igor R. ; Briere, Roy A. ; Cai, H. ; Cai, Xiao ; Cakir, O. ; Calcaterra, Alessandro ; Cao, G.F. ; Çetin, Serkant Ali ; Chang, Jinfan ; Chelkov, Gueorgui A. ; Chen, G. ; Chen, Hesheng ; Chen, H.Y. ; Chen, J.C. ; Chen, M.L. ; Chen, S.J. ; Chen, X. ; Chen, X.R. ; Chen, Yuanbo ; Cheng, H.P. ; Chu, X.K. ; Cibinetto, Gianluigi ; Dai, Hongliang ; Dai, J.P. ; Dbeyssi, Alaa ; Dedovich, Dmitri V. ; Deng, Ziyan ; Denig, Achim ; Denysenko, Igor ; Destefanis, Marco Giovanni Maria ; De Mori, Francesca ; Ding, Y. ; Dong, C. ; Dong, J. ; Dong, Liaoyuan ; Dong, Mingyi ; Du, Shuxian ; Duan, P.F. ; Eren, E.E. ; Fan, J.Z. ; Fang, J. ; Fang, Shuangshi ; Fang, X. ; Fang, Y. ; Fava, Luciano ; Feldbauer, Florian ; Felici, Giulietto ; Feng, C.Q. ; Fioravanti, Elisa ; Fritsch, Miriam ; Fu, Chengdong ; Gao, Q. ; Gao, X.Y. ; Gao, Y. ; Gao, Z. ; Garzia, I. ; Goetzen, Klaus ; Gong, Wenxuan ; Gradl, Wolfgang ; Greco, M. ; Gu, Minhao ; Gu, Y.T. ; Guan, Y.H. ; Guo, Aiqiang ; Guo, L.B. ; Guo, Y. ; Guo, Yuping ; Haddadi, Z. ; Hafner, A. ; Han, S. ; Hao, Xiqing ; Harris, F.A. ; He, K.L. ; He, X.Q. ; Held, T. ; Heng, Yuekun ; Hou, Zhilong ; Hu, C. ; Hu, Haiming ; Hu, J.F. ; Hu, T. ; Hu, Y. ; Huang, G.M. ; Huang, G.S. ; Huang, J.S. ; Huang, X.T. ; Huang, Y. ; Hussain, Tahir ; Ji, Quan ; Ji, Qingping ; Ji, X.B. ; Ji, X.L. ; Jiang, L.W. ; Jiang, Xiaoshan ; Jiang, X.Y. ; Jiao, J.B. ; Jiao, Z. ; Jin, D.P. ; Jin, Shan ; Johansson, Tord ; Julin, A. ; Kalantar-Nayestanaki, Nasser ; Kang, Xiaolin ; Kang, X.S. ; Kavatsyuk, Myroslav O. ; Ke, Bai-Cian ; Kiese, P. ; Kliemt, Ralf ; Kloss, B. ; Kolcu, Onur Bugra ; Kopf, Bertram ; Kornicer, M. ; Kühn, Wolfgang ; Kupsc, Andrzej ; Lange, Jens Sören ; Lara, M. ; Larin, Paul ; Leng, C. ; Li, C. ; Li, Cheng ; Li, D.M. ; Li, F. ; Li, F.Y. ; Li, G. ; Li, Haibo ; Li, J.C. ; Li, Jin ; Li, K. ; Li, K. ; Li, Lei ; Li, Peirong ; Li, T. ; Li, Weidong ; Li, Weiguo ; Li, X.L. ; Li, X.M. ; Li, X.N. ; Li, X.Q. ; Li, Z.B. ; Liang, H. ; Liang, Y.F. ; Liang, Y.T. ; Liao, G.R. ; Lin, D.X. ; Liu, B.J. ; Liu, C.X. ; Liu, Fu-Hu ; Liu, Fang ; Liu, Feng ; Liu, H.B. ; Liu, H.H. ; Liu, H.H. ; Liu, H.M. ; Liu, J. ; Liu, J.B. ; Liu, J.P. ; Liu, J.Y. ; Liu, K. ; Liu, K.Y. ; Liu, L.D. ; Liu, P.L. ; Liu, Q. ; Liu, S.B. ; Liu, X. ; Liu, Y.B. ; Liu, Zhen-An ; Liu, Zhiqing ; Loehner, H. ; Lou, Xinchou ; Lu, H.J. ; Lu, Junguang ; Lu, Y. ; Lu, Yunpeng ; Luo, Chenglin ; Luo, M.X. ; Luo, Tao ; Luo, X.L. ; Lyu, Xiao-Rui ; Ma, Fengcai ; Ma, Hailong ; Ma, Lianliang ; Ma, Qiumei ; Ma, T. ; Ma, X.N. ; Ma, Xiaoyan ; Maas, Frank E. ; Maggiora, Marco ; Mao, Yajun ; Mao, Zepu ; Marcello, Simonetta ; Messchendorp, Johannes Gerhardus ; Min, J. ; Mitchell, Ryan Edward ; Mo, Xiaohu ; Mo, Y.J. ; Morales Morales, C. ; Moriya, K. ; Muchnoi, Nikolai Yu. ; Muramatsu, H. ; Nefedov, Yury ; Nerling, Frank ; Nikolaev, Ivan Borisovich ; Ning, Z. ; Nisar, Shabana ; Niu, S.L. ; Niu, X.Y. ; Olsen, Stephen L. ; Ouyang, Qun ; Pacetti, Simone ; Patteri, P. ; Pelizäus, Marc ; Peng, H.P. ; Peters, Klaus ; Pettersson, J. ; Ping, J.L. ; Ping, R.G. ; Poling, Ronald ; Prasad, Vindhyawasini ; Qi, Ming ; Qian, S. ; Qiao, Congfeng ; Qin, L.Q. ; Qin, N. ; Qin, X.S. ; Qin, Zhonghua ; Qiu, Jinfa ; Rashid, K.H. ; Redmer, Christoph Florian ; Ripka, M. ; Rong, Gang ; Rosner, Christoph ; Ruan, X.D. ; Santoro, V. ; Sarantsev, Andrei V. ; Savrié, M. ; Schönning, Karin ; Schumann, S. ; Shan, Wei ; Shao, M. ; Shen, C.P. ; Shen, P.X. ; Shen, X.Y. ; Sheng, H.Y. ; Song, W.M. ; Shepherd, M.R. ; Song, X.Y. ; Sosio, Stefano ; Spataro, Stefano ; Sun, Gongxing ; Sun, J.F. ; Sun, S.S. ; Sun, Y.J. ; Sun, Y.Z. ; Sun, Z.J. ; Sun, Z.T. ; Tang, C.J. ; Tang, X. ; Tapan, I. ; Thorndike, E.H. ; Tiemens, M. ; Ullrich, M. ; Uman, Ismail ; Varner, G.S. ; Wang, B. ; Wang, D. ; Wang, D.Y. ; Wang, K. ; Wang, L.L. ; Wang, L.S. ; Wang, M. ; Wang, P. ; Wang, P.L. ; Wang, S.G. ; Wang, W. ; Wang, Xiongfei ; Wang, Y.D. ; Wang, Y.F. ; Wang, Y.Q. ; Wang, Z. ; Wang, Z.G. ; Wang, Z.H. ; Wang, Z.Y. ; Weber, T. ; Wei, D.H. ; Wei, J.B. ; Weidenkaff, P. ; Wen, Shuopin ; Wiedner, Ulrich ; Wolke, Magnus ; Wu, Linghui ; Wu, Z. ; Xia, L.G. ; Xia, Y. ; Xiao, D. ; Xiao, H. ; Xiao, Zhenjun ; Xie, Y.G. ; Xiu, Q.L. ; Xu, Guofa ; Xu, L. ; Xu, Q.J. ; Xu, Xinping ; Yan, Liang ; Yan, W.B. ; Yan, W.C. ; Yan, Y.H. ; Yang, H.J. ; Yang, Hongxun ; Yang, L. ; Yang, Y. ; Yang, Yongxu ; Ye, M. ; Ye, Minghan ; Yin, J.H. ; Yu, Boxiang ; Yu, C.X. ; Yu, J.S. ; Yuan, Chang-Zheng ; Yuan, W.L. ; Yuan, Y. ; Yuncu, A. ; Zafar, A.A. ; Zallo, A. ; Zeng, Y. ; Zhang, B.X. ; Zhang, B.Y. ; Zhang, C. ; Zhang, C.C. ; Zhang, D.H. ; Zhang, H.H. ; Zhang, Hongyu ; Zhang, J.J. ; Zhang, J.L. ; Zhang, J.Q. ; Zhang, J.W. ; Zhang, Jianyong ; Zhang, J.Z. ; Zhang, K. ; Zhang, L. ; Zhang, X.Y. ; Zhang, Y. ; Zhang, Y.N. ; Zhang, Y.H. ; Zhang, Yateng ; Zhang, Yu ; Zhang, Z.H. ; Zhang, Z.P. ; Zhang, Z.Y. ; Zhao, G. ; Zhao, J.W. ; Zhao, J.Y. ; Zhao, J.Z. ; Zhao, Lei ; Zhao, Ling ; Zhao, Ming-Gang ; Zhao, Q. ; Zhao, Q.W. ; Zhao, Shujun ; Zhao, T.C. ; Zhao, Yubin ; Zhao, Zhengguo ; Zhemchugov, Alexey ; Zheng, Bo ; Zheng, Jianping ; Zheng, W.J. ; Zheng, Y.H. ; Zhong, B. ; Zhou, L. ; Zhou, X. ; Zhou, X.K. ; Zhou, X.R. ; Zhou, X.Y. ; Zhu, K. ; Zhu, Kejun ; Zhu, S. ; Zhu, S.H. ; Zhu, X.L. ; Zhu, Y.C. ; Zhu, Y.S. ; Zhu, Zian ; Zhuang, J. ; Zotti, L. ; Zou, B.S. ; Zou, Jiaheng
We extract the e+e− →π+π− cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb−1 taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is measured with a systematic uncertainty of 0.9%. We extract the pion form factor |Fπ|2 as well as the contribution of the measured cross section to the leading-order hadronic vacuum polarization contribution to (g−2)μ. We find this value to be aππ,LO μ (600–900 MeV) = (368.2 ±2.5stat±3.3sys) ·10−10, which is between the corresponding values using the BaBar or KLOE data.
Ablikim, Medina ; Achasov, Mikhail N. ; Adlarson, Patrik ; Ahmed, Samer ; Albrecht, Malte ; Aliberti, Riccardo ; Amoroso, Antonio ; An, M. R. ; An, Qi ; Bai, Xuhong ; Bai, Y. ; Bakina, Olga ; Baldini Ferroli, Rinaldo ; Balossino, Ilaria ; Ban, Yong ; Begzsuren, Khurelbaatar ; Berger, Niklaus ; Bertani, Monica ; Bettoni, Diego ; Bianchi, Fabrizio ; Bloms, Johannes ; Bortone, Alberto ; Boyko, Igor R. ; Briere, Roy A. ; Cai, H. ; Cai, Xiao ; Calcaterra, Alessandro ; Cao, G. F. ; Cao, Ning ; Çetin, Serkant Ali ; Chang, Jinfan ; Chang, W. L. ; Chelkov, Gueorgui A. ; Chen, D. Y. ; Chen, G. ; Chen, Hesheng ; Chen, M. L. ; Chen, S. J. ; Chen, X. R. ; Chen, Yuanbo ; Chen, Z. J ; Cheng, W. S. ; Cibinetto, Gianluigi ; Cossio, Fabio ; Cui, X. F. ; Dai, Hongliang ; Dai, Xinchen ; Dbeyssi, Alaa ; Boer, Remco E. de ; Dedovich, Dmitri V. ; Deng, Ziyan ; Denig, Achim ; Denysenko, Igor ; Destefanis, Marco Giovanni Maria ; De Mori, Francesca ; Ding, Y. ; Dong, C. ; Dong, J. ; Dong, Liaoyuan ; Dong, Mingyi ; Dong, X. ; Du, Shuxian ; Fan, Y. L. ; Fang, J. ; Fang, Shuangshi ; Fang, Y. ; Farinelli, Riccardo ; Fava, Luciano ; Feldbauer, Florian ; Felici, Giulietto ; Feng, C. Q. ; Feng, J. H. ; Fritsch, Miriam ; Fu, Chengdong ; Gao, Y. ; Gao, Y. ; Gao, Y. ; Gao, Y. G. ; Garzia, I. ; Ge, Panting ; Geng, Cong ; Gersabeck, Evelina ; Gilman, Alexander ; Goetzen, Klaus ; Gong, L. ; Gong, Wenxuan ; Gradl, Wolfgang ; Greco, M. ; Gu, L. M. ; Gu, Minhao ; Gu, S. ; Gu, Y. T. ; Guan, C. Y ; Guo, Aiqiang ; Guo, L. B. ; Guo, R. P. ; Guo, Yuping ; Guskov, Alexey ; Han, T. T. ; Han, W. Y. ; Hao, Xiqing ; Harris, F. A. ; Hüsken, Nils ; He, K. L. ; Heinsius, Fritz-Herbert ; Heinz, C. H. ; Held, T. ; Heng, Yuekun ; Herold, Christoph ; Himmelreich, Mathilde ; Holtmann, Tobias ; Hou, G. Y. ; Hou, Y. R. ; Hou, Zhilong ; Hu, Haiming ; Hu, J. F. ; Hu, T. ; Hu, Y. ; Huang, G. S. ; Huang, L. Q. ; Huang, X. T. ; Huang, Y. P. ; Huang, Z. ; Hussain, Tahir ; Ikegami Andersson, Walter ; Imoehl, William ; Irshad, M. ; Jaeger, S. ; Janchiv, S. ; Ji, Quan ; Ji, Qingping ; Ji, X. B. ; Ji, X. L. ; Ji, Y. Y. ; Jiang, H. B. ; Jiang, Xiaoshan ; Jiao, J. B. ; Jiao, Z. ; Jin, Shan ; Jin, Y. ; Jing, M. Q. ; Johansson, Tord ; Kalantar-Nayestanaki, Nasser ; Kang, X. S. ; Kappert, Rosa ; Kavatsyuk, Myroslav O. ; Ke, Bai-Cian ; Keshk, Iman ; Khoukaz, Alfons ; Kiese, P. ; Kiuchi, Ryuta ; Kliemt, Ralf ; Koch, Leonard ; Kolcu, Onur Bugra ; Kopf, Bertram ; Kuemmel, M. ; Küßner, Meike ; Kupsc, Andrzej ; Kurth, M. G. ; Kühn, Wolfgang ; Lane, John Jake ; Lange, Jens Sören ; Larin, Paul ; Lavania, Anita ; Lavezzi, Lia ; Lei, Z. H. ; Leithoff, H. ; Lellmann, Max ; Lenz, Thomas ; Li, C. ; Li, Chunhua ; Li, C. ; Li, D. M. ; Li, F. ; Li, G. ; Li, H. ; Li, H. ; Li, Haibo ; Li, Huijing ; Li, J. L. ; Li, J. Q. ; Li, J. S. ; Li, K. ; Li, L. K. ; Li, L. ; Li, Peirong ; Li, S. Y. ; Li, Weidong ; Li, Weiguo ; Li, X. H. ; Li, X. L. ; Li, X. ; Li, Z. Y. ; Liang, H. ; Liang, H. ; Liang, H. ; Liang, Y. F. ; Liang, Y. T. ; Liao, G. R. ; Liao, L. Z. ; Libby, J. ; Lin, C. X. ; Liu, B. J. ; Liu, C. X. ; Liu, D. ; Liu, Fu-Hu ; Liu, F. ; Liu, F. ; Liu, H. B. ; Liu, H. M. ; Liu, H. ; Liu, H. ; Liu, J. B. ; Liu, J. L. ; Liu, J. Y. ; Liu, K. ; Liu, K. Y. ; Liu, L. ; Liu, Meihong ; Liu, P. L. ; Liu, Q. ; Liu, Q. ; Liu, S. B. ; Liu, S. ; Liu, T. ; Liu, Weimin ; Liu, X. ; Liu, Y. ; Liu, Y. B. ; Liu, Zhen-An ; Liu, Zhiqing ; Lou, Xinchou ; Lu, F. X. ; Lu, H. J. ; Lu, J. D. ; Lu, Junguang ; Lu, X. L. ; Lu, Y. ; Lu, Yunpeng ; Luo, Chenglin ; Luo, M. X. ; Luo, P. W. ; Luo, Tao ; Luo, X. L. ; Lyu, Xiao-Rui ; Ma, Fengcai ; Ma, Hailong ; Ma, Lianliang ; Ma, M. M. ; Ma, Qiumei ; Ma, R. Q. ; Ma, R. T. ; Ma, X. X. ; Ma, Xiaoyan ; Maas, Frank E. ; Maggiora, Marco ; Maldaner, Stephan ; Malde, Sneha ; Malik, Qadeer Afzal ; Mangoni, Alessio ; Mao, Yajun ; Mao, Zepu ; Marcello, Simonetta ; Meng, Z. X. ; Messchendorp, Johannes Gerhardus ; Mezzadri, Giulio ; Min, T. J. ; Mitchell, Ryan Edward ; Mo, Xiaohu ; Mo, Y. J. ; Muchnoi, Nikolai Yu. ; Muramatsu, H. ; Nakhoul, Simon ; Nefedov, Yury ; Nerling, Frank ; Nikolaev, Ivan Borisovich ; Ning, Z. ; Nisar, Shabana ; Olsen, Stephen L. ; Ouyang, Qun ; Pacetti, Simone ; Pan, X. ; Pan, Y. ; Pathak, A. ; Patteri, P. ; Pelizäus, Marc ; Peng, H. P. ; Peters, Klaus ; Pettersson, J. ; Ping, J. L. ; Ping, R. G. ; Poling, Ronald ; Prasad, Vindhyawasini ; Qi, H. ; Qi, H. R. ; Qi, K. H. ; Qi, Ming ; Qi, T. Y. ; Qian, S. ; Qian, W. B. ; Qian, Z. ; Qiao, Congfeng ; Qin, L. Q. ; Qin, X. P. ; Qin, X. S. ; Qin, Zhonghua ; Qiu, Jinfa ; Qu, S. Q. ; Rashid, K. H. ; Ravindran, Krishnakumar ; Redmer, Christoph Florian ; Rivetti, Angelo ; Rodin, Viktor ; Da Rocha Rolo, Manuel Dionisio ; Rong, Gang ; Rosner, Christoph ; Rump, Marcel Andre ; Sang, H. S. ; Sarantsev, Andrei V. ; Schelhaas, Yasemin ; Schnier, Claudius ; Schönning, Karin ; Scodeggio, Marco ; Shan, D. C. ; Shan, Wei ; Shan, Xinyu ; Shangguan, J. F. ; Shao, M. ; Shen, C. P. ; Shen, H. F. ; Shen, P. X. ; Shen, X. Y. ; Shi, Huangchao ; Shi, Rongsheng ; Shi, X. ; Shi, X. D ; Song, J. J. ; Song, W. M. ; Song, Yunxuan ; Sosio, Stefano ; Spataro, Stefano ; Su, K. X. ; Su, P. P. ; Sui, F. F. ; Sun, Gongxing ; Sun, H. K. ; Sun, J. F. ; Sun, L. ; Sun, S. S. ; Sun, T. ; Sun, W. Y. ; Sun, W. Y. ; Sun, X. ; Sun, Y. J. ; Sun, Y. K. ; Sun, Y. Z. ; Sun, Z. T. ; Tan, Y. H. ; Tan, Y. X. ; Tang, C. J. ; Tang, G. Y. ; Tang, J. ; Teng, J. X. ; Thoren, Viktor ; Tian, W. H. ; Tian, Y. T. ; Uman, Ismail ; Wang, B. ; Wang, C. W. ; Wang, D. Y. ; Wang, H. J. ; Wang, H. P. ; Wang, K. ; Wang, L. L. ; Wang, M. ; Wang, M. Z. ; Wang, M. ; Wang, W. ; Wang, W. H. ; Wang, W. P. ; Wang, X. ; Wang, Xiongfei ; Wang, X. L. ; Wang, Y. ; Wang, Y. ; Wang, Y. D. ; Wang, Y. F. ; Wang, Y. Q. ; Wang, Y. Y. ; Wang, Z. ; Wang, Z. Y. ; Wang, Z. ; Wang, Z. ; Wei, D. H. ; Weidner, Frederik ; Wen, Shuopin ; White, D. J. ; Wiedner, Ulrich ; Wilkinson, G. ; Wolke, Magnus ; Wollenberg, Leonard ; Wu, J. F. ; Wu, Linghui ; Wu, Lianjin ; Wu, Xiao ; Wu, Z. ; Xia, L. ; Xiao, H. ; Xiao, S. Y. ; Xiao, Zhenjun ; Xie, X. H. ; Xie, Y. G. ; Xie, Y. H. ; Xing, T. Y. ; Xu, Guofa ; Xu, Q. J. ; Xu, W. ; Xu, Xinping ; Xu, Y. C. ; Yan, F. ; Yan, Liang ; Yan, W. B. ; Yan, W. C. ; Yan, X. ; Yang, H. J. ; Yang, Hongxun ; Yang, L. ; Yang, S. L. ; Yang, Yongxu ; Yang, Y. ; Yang, Z. ; Ye, M. ; Ye, Minghan ; Yin, J. H. ; You, Z. Y. ; Yu, Boxiang ; Yu, C. X. ; Yu, G. ; Yu, J. S. ; Yu, T. ; Yuan, Chang-Zheng ; Yuan, L. ; Yuan, X. Q. ; Yuan, Y. ; Yuan, Z. Y. ; Yue, C. X. ; Yuncu, A. ; Zafar, A. A. ; Zeng, X. ; Zeng, Y. ; Zhang, A. Q. ; Zhang, B. X. ; Zhang, G. ; Zhang, H. ; Zhang, H. H. ; Zhang, H. H. ; Zhang, Hongyu ; Zhang, J. J. ; Zhang, J. L. ; Zhang, J. Q. ; Zhang, J. W. ; Zhang, Jianyong ; Zhang, J. Z. ; Zhang, J. ; Zhang, J. ; Zhang, L. M. ; Zhang, Liqing ; Zhang, L. ; Zhang, S. ; Zhang, S. F. ; Zhang, S. ; Zhang, X. D. ; Zhang, X. Y. ; Zhang, Y. ; Zhang, Y. H. ; Zhang, Yateng ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z. H. ; Zhang, Z. Y. ; Zhao, G. ; Zhao, J. ; Zhao, J. Y. ; Zhao, J. Z. ; Zhao, L. ; Zhao, L. ; Zhao, Ming-Gang ; Zhao, Q. ; Zhao, Shujun ; Zhao, Yubin ; Zhao, Y. X. ; Zhao, Zhengguo ; Zhemchugov, Alexey ; Zheng, Bo ; Zheng, Jianping ; Zheng, Y. ; Zheng, Y. H. ; Zhong, B. ; Zhong, C. ; Zhou, L. P. ; Zhou, Q. ; Zhou, X. ; Zhou, X. K. ; Zhou, X. R. ; Zhou, X. Y. ; Zhu, A. N. ; Zhu, J. ; Zhu, K. ; Zhu, Kejun ; Zhu, S. H. ; Zhu, T. J. ; Zhu, W. J. ; Zhu, W. J. ; Zhu, Y. C. ; Zhu, Zian ; Zou, B. S. ; Zou, Jiaheng
Using 10.1 × 109 J/ψ events produced by the Beijing Electron Positron Collider (BEPCII) at a center-of-mass energy √s = 3.097 GeV and collected with the BESIII detector, we present a search for the rare semi-leptonic decay J/ψ → D−e+νe + c.c. No excess of signal above background is observed, and an upper limit on the branching fraction B(J/ψ → D−e +νe + c.c.) < 7.1 × 10−8 is obtained at 90% confidence level. This is an improvement of more than two orders of magnitude over the previous best limit.
Yu, Wei ; Ma, Xueyan ; Xu, Jinjin ; Heumüller, Andreas ; Fei, Zhaoliang ; Feng, Xue ; Wang, Xiaodong ; Liu, Kuo ; Li, Jinhui ; Cui, Guizhong ; Peng, Guangdun ; Ji, Hongbin ; Li, Jinsong ; Jing, Naihe ; Song, Hai ; Lin, Zhiqiang ; Zhao, Yun ; Wang, Zuoyun ; Zhou, Bin ; Zhang, Lei
Heart valve disease is a major clinical problem worldwide. Cardiac valve development and homeostasis need to be precisely controlled. Hippo signaling is essential for organ development and tissue homeostasis, while its role in valve formation and morphology maintenance remains unknown. VGLL4 is a transcription cofactor in vertebrates and we found it was mainly expressed in valve interstitial cells at the post-EMT stage and was maintained till the adult stage. Tissue specific knockout of VGLL4 in different cell lineages revealed that only loss of VGLL4 in endothelial cell lineage led to valve malformation with expanded expression of YAP targets. We further semi-knockout YAP in VGLL4 ablated hearts, and found hyper proliferation of arterial valve interstitial cells was significantly constrained. These findings suggest that VGLL4 is important for valve development and manipulation of Hippo components would be a potential therapy for preventing the progression of congenital valve disease.
The genus Afronurus has several very common mayfly species in China and they are widely distributed in this country. Some of them are quite similar to each other in both imaginal and nymphal stages. However, these species have not been systematically compared and reviewed so far. In this study, six species are recognized. All nymphs of them share the following characters: gills V–VI with additional arrow-like accessory lobes, branched dentisetae, two rows of bristles and setae on hindtibiae and spotted abdominal terga. The males have divergent penes and clearly expressed titillators. The nymphs of the new species A. drepanophyllus sp. nov. have sickle-like gills I, spotted and striped body color, and males have unique genitalia. The nymphal stages of A. furcatus and A. hunanensis, which are associated and described for the first time, have similar body color to A. drepanophyllus sp. nov., but their pale dots on the head capsules and the shape of the hypopharynx are different. Keys to males and nymphs of the six species are provided.
Riedl, Marc A. ; Aygören-Pürsün, Emel ; Baker, James ; Farkas, Henriette ; Anderson, John ; Bernstein, Jonathan A. ; Bouillet, Laurence ; Busse, Paula J. ; Manning, Michael ; Magerl, Markus ; Gompels, Mark ; Huissoon, Aarn P. ; Longhurst, Hilary ; Lumry, William ; Ritchie, Bruce ; Shapiro, Ralph ; Soteres, Daniel ; Banerji, Aleena ; Cancian, Mauro ; Johnston, Douglas T. ; Craig, Timothy ; Launay, David ; Li, Henry ; Liebhaber, Myron ; Nickel, Timothy ; Offenberger, Jacob ; Rae, William ; Schrijvers, Rik ; Triggiani, Massimo ; Wedner, H. James ; Dobo, Sylvia ; Cornpropst, Melanie ; Clemons, Desiree ; Fang, Lei ; Collis, Phil ; Sheridan, William P. ; Maurer, Marcus
Background: Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor (C1‐INH‐HAE) by reducing the frequency of angioedema attacks. Avoralstat is a small molecule inhibitor of plasma kallikrein. This study (OPuS‐2) evaluated the efficacy and safety of prophylactic avoralstat 300 or 500 mg compared with placebo.
Methods: OPuS‐2 was a Phase 3, multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group study. Subjects were administered avoralstat 300 mg, avoralstat 500 mg, or placebo orally 3 times per day for 12 weeks. The primary efficacy endpoint was the angioedema attack rate based on adjudicator‐confirmed attacks.
Results: A total of 110 subjects were randomized and dosed. The least squares (LS) mean attack rates per week were 0.589, 0.675, and 0.593 for subjects receiving avoralstat 500 mg, avoralstat 300 mg, and placebo, respectively. Overall, 1 subject in each of the avoralstat groups and no subjects in the placebo group were attack‐free during the 84‐day treatment period. The LS mean duration of all confirmed attacks was 25.4, 29.4, and 31.4 hours for the avoralstat 500 mg, avoralstat 300 mg, and placebo groups, respectively. Using the Angioedema Quality of Life Questionnaire (AE‐QoL), improved QoL was observed for the avoralstat 500 mg group compared with placebo. Avoralstat was generally safe and well tolerated.
Conclusions: Although this study did not demonstrate efficacy of avoralstat in preventing angioedema attacks in C1‐INH‐HAE, it provided evidence of shortened angioedema episodes and improved QoL in the avoralstat 500 mg treatment group compared with placebo.
In this study, a portable electronic nose (E-nose) prototype is developed using metal oxide semiconductor (MOS) sensors to detect odors of different wines. Odor detection facilitates the distinction of wines with different properties, including areas of production, vintage years, fermentation processes, and varietals. Four popular machine learning algorithms—extreme gradient boosting (XGBoost), random forest (RF), support vector machine (SVM), and backpropagation neural network (BPNN)—were used to build identification models for different classification tasks. Experimental results show that BPNN achieved the best performance, with accuracies of 94% and 92.5% in identifying production areas and varietals, respectively; and SVM achieved the best performance in identifying vintages and fermentation processes, with accuracies of 67.3% and 60.5%, respectively. Results demonstrate the effectiveness of the developed E-nose, which could be used to distinguish different wines based on their properties following selection of an optimal algorithm.
Yang, Bowen ; Goh, Yin Min ; Sung, Suk Hyun ; Ye, Gaihua ; Biswas, Sananda ; Kaib, David A. S. ; Dhakal, Ramesh ; Yan, Shaohua ; Li, Chenghe ; Jiang, Shengwei ; Chen, Fangchu ; Lei, Hechang ; He, Rui ; Valentí, Roser ; Winter, Stephen M. ; Hovden, Robert ; Tsen, Adam W.
Layered {\alpha}-RuCl3 is a promising material to potentially realize the long-sought Kitaev quantum spin liquid with fractionalized excitations. While evidence of this exotic state has been reported under a modest in-plane magnetic field, such behavior is largely inconsistent with theoretical expectations of Kitaev phases emerging only in out-of-plane fields. These predicted field-induced states have been mostly out of reach due to the strong easy-plane anisotropy of bulk crystals, however. We use a combination of tunneling spectroscopy, magnetotransport, electron diffraction, and ab initio calculations to study the layer-dependent magnons, anisotropy, structure, and exchange coupling in atomically thin samples. Due to structural distortions, the sign of the average off-diagonal exchange changes in monolayer {\alpha}-RuCl3, leading to a reversal of magnetic anisotropy to easy-axis. Our work provides a new avenue to tune the magnetic interactions in {\alpha}-RuCl3 and allows theoretically predicted quantum spin liquid phases for out-of-plane fields to be more experimentally accessible.
Théry, Clotilde ; Witwer, Kenneth W. ; Aikawa, Elena ; Alcaraz, Maria Jose ; Anderson, Johnathon D. ; Andriantsitohaina, Ramaroson ; Antoniou, Anna ; Arab, Tanina ; Archer, Fabienne ; Atkin-Smith, Georgia K. ; Ayre, D. Craig ; Bach, Jean-Marie ; Bachurski, Daniel ; Baharvand, Hossein ; Balaj, Leonora ; Baldacchino, Shawn ; Bauer, Natalie N. ; Baxter, Amy A. ; Bebawy, Mary ; Beckham, Carla ; Zavec, Apolonija Bedina ; Benmoussa, Abderrahim ; Berardi, Anna C. ; Bergese, Paolo ; Bielska, Ewa ; Blenkiron, Cherie ; Bobis-Wozowicz, Sylwia ; Boilard, Eric ; Boireau, Wilfrid ; Bongiovanni, Antonella ; Borràs, Francesc E. ; Bosch, Steffi ; Boulanger, Chantal M. ; Breakefield, Xandra ; Breglio, Andrew M. ; Brennan, Meadhbh Aín ; Brigstock, David R. ; Brisson, Alain ; Broekman, Marike L. D. ; Bromberg, Jacqueline F. ; Bryl-Gorecka, Paulina ; Buch, Shilpa ; Buck, Amy H. ; Burger, Dylan ; Busatto, Sara ; Buschmann, Dominik ; Bussolati, Benedetta ; Buzás, Edit I. ; Byrd, James Bryan ; Camussi, Giovanni ; Carter, David R. F. ; Caruso, Sarah ; Chamley, Lawrence W. ; Chang, Yu-Ting ; Chen, Chihchen ; Chen, Shuai ; Cheng, Lesley ; Chin, Andrew R. ; Clayton, Aled ; Clerici, Stefano P. ; Cocks, Alex ; Cocucci, Emanuele ; Coffey, Robert J. ; Cordeiro-da-Silva, Anabela ; Couch, Yvonne ; Coumans, Frank A. W. ; Coyle, Beth ; Crescitelli, Rossella ; Criado, Miria Ferreira ; D’Souza-Schorey, Crislyn ; Das, Saumya ; Chaudhuri, Amrita Datta ; de-Candia, Paola ; De Santana, Eliezer F. ; De Wever, Olivier ; del Portillo, Hernando A. ; Demaret, Tanguy ; Deville, Sarah ; Devitt, Andrew ; Dhondt, Bert ; Di Vizio, Dolores ; Dieterich, Lothar C. ; Dolo, Vincenza ; Dominguez Rubio, Ana Paula ; Dominici, Massimo ; Dourado, Mauricio R. ; Driedonks, Tom A. P. ; Duarte, Filipe V. ; Duncan, Heather M. ; Eichenberger, Ramon Marc ; Ekström, Karin ; El Andaloussi, Samir ; Elie-Caille, Celine ; Erdbrügger, Uta ; Falcón-Pérez, Juan M. ; Fatima, Farah ; Fish, Jason E. ; Flores-Bellver, Miguel ; Försönits, András ; Frelet-Barrand, Annie ; Fricke, Fabia ; Fuhrmann, Gregor ; Gabrielsson, Susanne ; Gámez-Valero, Ana ; Gardiner, Chris ; Gärtner, Kathrin ; Gaudin, Raphael ; Gho, Yong Song ; Giebel, Bernd ; Gilbert, Caroline ; Gimona, Mario ; Giusti, Ilaria ; Goberdhan, Deborah C. I. ; Görgens, André ; Gorski, Sharon M. ; Greening, David W. ; Groß, Julia Christina ; Gualerzi, Alice ; Gupta, Gopal N. ; Gustafson, Dakota ; Handberg, Aase ; Haraszti, Réka Ágnes ; Harrison, Paul ; Hegyesi, Hargita ; Hendrix, An ; Hill, Andrew F. ; Hochberg, Fred H. ; Hoffmann, Karl F. ; Holder, Beth ; Holthofer, Harry ; Hosseinkhani, Baharak ; Hu, Guoku ; Huang, Yiyao ; Huber, Veronica ; Hunt, Stuart ; Ibrahim, Ahmed Gamal-Eldin ; Ikezu, Tsuneya ; Inal, Jameel M. ; Isin, Mustafa ; Ivanova, Alena ; Jackson, Hannah K. ; Jacobsen, Soren ; Jay, Steven M. ; Jayachandran, Muthuvel ; Jenster, Guido ; Jiang, Lanzhou ; Johnson, Suzanne M. ; Jones, Jennifer C. ; Jong, Ambrose ; Jovanovic-Talisman, Tijana ; Jung, Stephanie ; Kalluri, Raghu ; Kano, Shin-ichi ; Kaur, Sukhbir ; Kawamura, Yumi ; Keller, Evan T. ; Khamari, Delaram ; Khomyakova, Elena ; Khvorova, Anastasia ; Kierulf, Peter ; Kim, Kwang Pyo ; Kislinger, Thomas ; Klingeborn, Mikael ; Klinke, David J. ; Kornek, Miroslaw ; Kosanović, Maja M. ; Kovács, Árpád Ferenc ; Krämer-Albers, Eva-Maria ; Krasemann, Susanne ; Krause, Mirja ; Kurochkin, Igor V. ; Kusuma, Gina D. ; Kuypers, Sören ; Laitinen, Saara ; Langevin, Scott M. ; Languino, Lucia R. ; Lannigan, Joanne ; Lässer, Cecilia ; Laurent, Louise C. ; Lavieu, Gregory ; Lázaro-Ibáñez, Elisa ; Le Lay, Soazig ; Lee, Myung-Shin ; Lee, Yi Xin Fiona ; Lemos, Debora S. ; Lenassi, Metka ; Leszczynska, Aleksandra ; Li, Isaac T. S. ; Liao, Ke ; Libregts, Sten F. ; Ligeti, Erzsebet ; Lim, Rebecca ; Lim, Sai Kiang ; Linē, Aija ; Linnemannstöns, Karen ; Llorente, Alicia ; Lombard, Catherine Ann ; Lorenowicz, Magdalena J. ; Lörincz, Ákos M. ; Lötvall, Jan ; Lovett, Jason ; Lowry, Michelle C. ; Loyer, Xavier ; Lu, Quan ; Lukomska, Barbara ; Lunavat, Taral Rameshchand ; Maas, Sybren L. N. ; Malhi, Harmeet ; Marcilla, Antonio ; Mariani, Jacopo ; Mariscal, Javier ; Martens-Uzunova, Elena S. ; Martin-Jaular, Lorena ; Martinez, M. Carmen ; Martins, Vilma Regina ; Mathieu, Mathilde ; Mathivanan, Suresh ; Maugeri, Marco ; McGinnis, Lynda K. ; McVey, Mark J. ; Meckes, David G. ; Meehan, Katie ; Mertens, Inge ; Minciacchi, Valentina R. ; Möller, Andreas ; Møller Jørgensen, Malene ; Morales-Kastresana, Aizea ; Morhayim, Jess ; Mullier, François ; Muraca, Maurizio ; Musante, Luca ; Mussack, Veronika ; Muth, Dillon C. ; Myburgh, Kathryn H. ; Najrana, Tanbir ; Nawaz, Muhammad ; Nazarenko, Irina ; Nejsum, Peter ; Neri, Christian ; Neri, Tommaso ; Nieuwland, Rienk ; Nimrichter, Leonardo ; Nolan, John P. ; Nolte-’t Hoen, Esther N. M. ; Hooten, Nicole Noren ; O’Driscoll, Lorraine ; O’Grady, Tina ; O’Loghlen, Ana ; Ochiya, Takahiro ; Olivier, Martin ; Ortiz, Alberto ; Ortiz, Luis A. ; Osteikoetxea, Xabier ; Østergaard, Ole ; Ostrowski, Matias ; Park, Jaesung ; Pegtel, Dirk Michiel ; Peinado, Hector ; Perut, Francesca ; Pfaffl, Michael ; Phinney, Donald G. ; Pieters, Bartijn C. H. ; Pink, Ryan Charles ; Pisetsky, David S. ; Pogge von Strandmann, Elke ; Polakovicova, Iva ; Poon, Ivan K. H. ; Powell, Bonita H. ; Prada, Ilaria ; Pulliam, Lynn ; Quesenberry, Peter ; Radeghieri, Annalisa ; Raffai, Robert L. ; Raimondo, Stefania ; Rak, Janusz ; Ramirez, Marcel I. ; Raposo, Graça ; Rayyan, Morsi S. ; Regev-Rudzki, Neta ; Ricklefs, Franz Lennard ; Robbins, Paul D. ; Roberts, David D. ; Rodrigues, Silvia C. ; Rohde, Eva ; Rome, Sophie ; Rouschop, Kasper M. ; Rughetti, Aurelia ; Russell, Ashley E. ; Saá, Paula ; Sahoo, Susmita ; Salas-Huenuleo, Edison ; Sánchez, Catherine ; Saugstad, Julie A. ; Saul, Meike J. ; Schiffelers, Raymond M. ; Schneider, Raphael ; Schøyen, Tine Hiorth ; Scott, Aaron ; Shahaj, Eriomina ; Sharma, Shivani ; Shatnyeva, Olga ; Shekari, Faezeh ; Shelke, Ganesh Vilas ; Shetty, Ashok K. ; Shiba, Kiyotaka ; Siljander, Pia R.-M. ; Silva, Andreia M. ; Skowronek, Agata ; Snyder, Orman L. ; Soares, Rodrigo Pedro ; Sódar, Barbara W. ; Soekmadji, Carolina ; Sotillo, Javier ; Stahl, Philip D. ; Stoorvogel, Willem ; Stott, Shannon L. ; Strasser, Erwin F. ; Swift, Simon ; Tahara, Hidetoshi ; Tewari, Muneesh ; Timms, Kate ; Tiwari, Swasti ; Tixeira, Rochelle ; Tkach, Mercedes ; Toh, Wei Seong ; Tomasini, Richard ; Torrecilhas, Ana Claudia ; Tosar, Juan Pablo ; Toxavidis, Vasilis ; Urbanelli, Lorena ; Vader, Pieter ; Balkom, Bastiaan Wilhelmus Maria van ; Grein, Susanne G. van der ; Van Deun, Jan ; Herwijnen, Martijn J. C. van ; Van Keuren-Jensen, Kendall R. ; Niel, Guillaume van ; Royen, Martin E. van ; Wijnen, Andre J. van ; Vasconcelos, M. Helena ; Vechetti, Ivan J. ; Veit, Tiago D. ; Vella, Laura J. ; Velot, Émilie ; Verweij, Frederik ; Vestad, Beate ; Viñas, Jose Luis ; Visnovitz, Tamás ; Vukman, Krisztina V. ; Wahlgren, Jessica ; Watson, Dionysios C. ; Wauben, Marca H. M. ; Weaver, Alissa ; Webber, Jason P. ; Weber, Viktoria ; Wehman, Ann M. ; Weiss, Daniel J. ; Welsh, Joshua A. ; Wendt, Sebastian ; Wheelock, Åsa M. ; Wiener, Zoltán ; Witte, Leonie ; Wolfram, Joy ; Xagorari, Angeliki ; Xander, Patricia ; Xu, Jing ; Yan, Xiaomei ; Yáñez-Mó, María ; Yin, Hang ; Yuana, Yuana ; Zappulli, Valentina ; Zarubova, Jana ; Žėkas, Vytautas ; Zhang, Jian-ye ; Zhao, Zezhou ; Zheng, Lei ; Zheutlin, Alexander R. ; Zickler, Antje Maria ; Zimmermann, Pascale ; Zivkovic, Angela M. ; Zocco, Davide ; Zuba-Surma, Ewa K.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Escott-Price, Valentina ; Bellenguez, Céline ; Wang, Li-San ; Choi, Seung-Hoan ; Harold, Denise ; Jones, Lesley ; Holmans, Peter ; Gerrish, Amy ; Vedernikov, Alexey ; Richards, Alexander ; DeStefano, Anita L. ; Lambert, Jean-Charles ; Ibrahim-Verbaas, Carla A. ; Naj, Adam C. ; Sims, Rebecca ; Jun, Gyungah ; Bis, Joshua C. ; Beecham, Gary W. ; Grenier-Boley, Benjamin ; Russo, Giancarlo ; Thornton-Wells, Tricia A. ; Denning, Nicola ; Smith, Albert V. ; Chouraki, Vincent ; Thomas, Charlene ; Ikram, M. Arfan ; Zelenika, Diana ; Vardarajan, Badri N. ; Kamatani, Yoichiro ; Lin, Chiao-Feng ; Schmidt, Helena ; Kunkle, Brian ; Dunstan, Melanie L. ; Vronskaya, Maria ; Johnson, Andrew D. ; Ruiz, Agustin ; Bihoreau, Marie-Thérèse ; Reitz, Christiane ; Pasquier, Florence ; Hollingworth, Paul ; Hanon, Olivier ; Fitzpatrick, Annette L. ; Buxbaum, Joseph D. ; Campion, Dominique ; Crane, Paul K. ; Baldwin, Clinton ; Becker, Tim ; Gudnason, Vilmundur ; Cruchaga, Carlos ; Craig, David ; Amin, Najaf ; Berr, Claudine ; Lopez, Oscar L. ; Jager, Philip L. De ; Deramecourt, Vincent ; Johnston, Janet A. ; Evans, Denis ; Lovestone, Simon ; Letenneur, Luc ; Hernández, Isabel ; Rubinsztein, David C. ; Eiriksdottir, Gudny ; Sleegers, Kristel ; Goate, Alison M. ; Fiévet, Nathalie ; Huentelman, Matthew J. ; Gill, Michael ; Brown, Kristelle ; Kamboh, M. Ilyas ; Keller, Lina ; Barberger-Gateau, Pascale ; McGuinness, Bernadette ; Larson, Eric B. ; Myers, Amanda J. ; Dufouil, Carole ; Todd, Stephen ; Wallon, David ; Love, Seth ; Rogaeva, Ekaterina ; Gallacher, John ; St George-Hyslop, Peter ; Clarimon, Jordi ; Lleo, Alberto ; Bayer, Anthony ; Tsuang, Debby W. ; Yu, Lei ; Tsolaki, Magda ; Bossù, Paola ; Spalletta, Gianfranco ; Proitsi, Petra ; Collinge, John ; Sorbi, Sandro ; Sanchez Garcia, Florentino ; Fox, Nick C. ; Hardy, John ; Deniz Naranjo, Maria Candida ; Bosco, Paolo ; Clarke, Robert ; Brayne, Carol ; Galimberti, Daniela ; Scarpini, Elio ; Bonuccelli, Ubaldo ; Mancuso, Michelangelo ; Siciliano, Gabriele ; Moebus, Susanne ; Mecocci, Patrizia ; Del Zompo, Maria ; Maier, Wolfgang ; Hampel, Harald ; Pilotto, Alberto ; Frank-García, Ana ; Panza, Francesco ; Solfrizzi, Vincenzo ; Caffarra, Paolo ; Nacmias, Benedetta ; Perry, William ; Mayhaus, Manuel ; Lannfelt, Lars ; Hakonarson, Hakon ; Pichler, Sabrina ; Carrasquillo, Minerva M. ; Ingelsson, Martin ; Beekly, Duane ; Alvarez, Victoria ; Zou, Fanggeng ; Valladares, Otto ; Younkin, Steven G. ; Coto, Eliecer ; Hamilton-Nelson, Kara L. ; Gu, Wei ; Razquin, Cristina ; Pastor, Pau ; Mateo, Ignacio ; Owen, Michael J. ; Faber, Kelley M. ; Jonsson, Palmi V. ; Combarros, Onofre ; O'Donovan, Michael C. ; Cantwell, Laura B. ; Soininen, Hilkka ; Blacker, Deborah ; Mead, Simon ; Mosley, Thomas H. ; Bennett, David A. ; Harris, Tamara B. ; Fratiglioni, Laura ; Holmes, Clive ; Bruijn, Renee F. A. G. de ; Passmore, Peter ; Montine, Thomas J. ; Bettens, Karolien ; Rotter, Jerome I. ; Brice, Alexis ; Morgan, Kevin ; Foroud, Tatiana M. ; Kukull, Walter A. ; Hannequin, Didier ; Powell, John F. ; Nalls, Michael A. ; Ritchie, Karen ; Lunetta, Kathryn L. ; Kauwe, John S. K. ; Boerwinkle, Eric ; Riemenschneider, Matthias ; Boada, Mercè ; Hiltunen, Mikko ; Martin, Eden R. ; Schmidt, Reinhold ; Rujescu, Dan ; Dartigues, Jean-François ; Mayeux, Richard ; Tzourio, Christophe ; Hofman, Albert ; Nöthen, Markus Maria ; Graff, Caroline ; Psaty, Bruce M. ; Haines, Jonathan L. ; Lathrop, Mark ; Pericak-Vance, Margaret Ann ; Launer, Lenore J. ; Broeckhoven, Christine Van ; Farrer, Lindsay A. ; Duijn, Cornelia M. van ; Ramirez, Alfredo ; Seshadri, Sudha ; Schellenberg, Gerard D. ; Amouyel, Philippe ; Williams, Julie
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.