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Hulsik, David Lutje ; Liu, Ying-ying ; Strokappe, Nika M. ; Battella, Simone ; El Khattabi, Mohamed ; McCoy, Laura E. ; Sabin, Charles ; Hinz, Andreas ; Hock, Miriam ; Macheboeuf, Pauline ; Bonvin, Alexandre M. J. J. ; Langedijk, Johannes P. M. ; Davis, David ; Forsman Quigley, Anna ; Aasa-Chapman, Marlén M. I. ; Seaman, Michael S. ; Ramos, Alejandra ; Poignard, Pascal ; Favier, Adrien ; Simorre, Jean-Pierre ; Weiss, Robin A. ; Verrips, C. Theo ; Weissenhorn, Winfried ; Rutten, Lucy
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies. We immunized llamas with gp41-MPER proteoliposomes and selected a MPER-specific single chain antibody (VHH), 2H10, whose epitope overlaps with that of mAb 2F5. Bi-2H10, a bivalent form of 2H10, which displayed an approximately 20-fold increased affinity compared to the monovalent 2H10, neutralized various sensitive and resistant HIV-1 strains, as well as SHIV strains in TZM-bl cells. X-ray and NMR analyses combined with mutagenesis and modeling revealed that 2H10 recognizes its gp41 epitope in a helical conformation. Notably, tryptophan 100 at the tip of the long CDR3 is not required for gp41 interaction but essential for neutralization. Thus bi-2H10 is an anti-MPER antibody generated by immunization that requires hydrophobic CDR3 determinants in addition to epitope recognition for neutralization similar to the mode of neutralization employed by mAbs 2F5 and 4E10.
Abdulhamid, Muhammad Ibrahim ; Aboona, Bassam ; Adam, Jaroslav ; Adams, Joseph ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, Alisher ; Alekseev, Igor ; Anderson, Derek ; Aparin, Alexey ; Aslam, Sameer ; Atchison, Joseph ; Averichev, Georgy ; Bairathi, Vipul ; Baker, William ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bordyuzhin, Igor G. ; Brandenburg, James ; Brandin, Andrei ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel ; Češka, Jakub ; Chakaberia, Irakli ; Chan, Brian ; Chang, Zilong ; Chatterjee, Arghya ; Chen, Ding ; Chen, J. ; Chen, J.H. ; Chen, Zhenyu ; Cheng, Jianping ; Cheng, Yunshan ; Choudhury, Subikash ; Christie, Bill ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Dale-Gau, Gabriel ; Das, Ayanabha ; Daugherity, Michael ; Dedovich, Tatiana ; Deppner, Ingo Martin ; Derevschikov, Anatoly ; Dhamija, Arushi ; Di Carlo, Launa ; Dixit, Prabhupada ; Dong, Xin ; Drachenberg, James ; Duckworth, Emilie ; Dunlop, James ; Engelage, Jack ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga ; Ewigleben, Annika ; Eyser, Kjeld Oleg ; Fatemi, Renee ; Fazio, Salvatore ; Feng, Chan-Jui ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Flor, Fernando Antonio ; Fu, Chuan ; Gao, Taoya ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, Xingrui ; Grosnick, David P. ; Gupta, Anik ; Hamed, Ahmed ; Han, Yiding ; Harasty, Matthew D. ; Harris, John W. ; Harrison-Smith, Hannah ; He, Wanbing ; He, Xionghong ; He, Yang ; Hu, Chenlu ; Hu, Qiang ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, Te-Chuan ; Huang, Xinjie ; Huang, Y. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, Donald ; Isshiki, Moe ; Jacobs, William ; Jalotra, Ashish ; Jena, Chitrasen ; Ji, Yuanjing ; Jia, Jiangyong ; Jin, Chenliang ; Ju, Xin-Yue ; Judd, Eleanor ; Kabana, Sonia ; Kabir, Md Latiful ; Kalinkin, Dmitry ; Kang, Kejun ; Kapukchyan, David ; Kauder, Kolja ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Kimelman, Benjamin ; Kiselev, Alexander ; Knospe, Anders ; Ko, Ho San ; Kochenda, Leonid ; Korobitsin, Artem ; Kravtsov, Petr ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Lacey, Roy Alphanso ; Landgraf, Jeffery ; Lebedev, Alexei ; Lednicky, Richard ; Lee, Jeong-Hun ; Leung, Yue-Hang ; Lewis, Nicole ; Li, Changfeng ; Li, Wei ; Li, Xiujun ; Li, Y. ; Li, Y. ; Li, Ziyang ; Liang, Xilin ; Liang, Yue ; Lin, Ting ; Liu, Chengyang ; Liu, Feng ; Liu, Guoming ; Liu, H. ; Liu, H. ; Liu, Li-ke ; Liu, Tong ; Liu, Xiaoyu ; Liu, Yanfang ; Liu, Zuowen ; Ljubicic, Tonko ; Llope, William Joseph ; Lomicky, Ondrej ; Longacre, Ronald S. ; Loyd, E.M. ; Lu, Tan ; Lukow, Nicholas ; Luo, Xiaofeng ; Luong, V.B. ; Ma, Long ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spiros ; Matis, Howard ; Mazer, Joel Anthony ; McNamara, Grant ; Mi, K. ; Minaev, Nikolai ; Mohanty, Bedanga ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry ; Mudrokh, Aleksandr ; Nagy, Marton ; Nain, Ankita ; Nam, J.D. ; Nasim, M. ; Neff, Dylan ; Nelson, John M. ; Nemes, Daniel ; Nie, Maowu ; Nigmatkulov, Grigory ; Niida, Takafumi ; Nishitani, Risa ; Nogach, Larisa ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Okubo, Kosuke ; Page, Brian ; Pak, Robert ; Pan, Jinjin ; Pandav, Ashish ; Pandey, Ashutosh ; Panebratsev, Yuri ; Pani, Tanmay ; Parfenov, Petr ; Paul, Ananya ; Perkins, Chris ; Pokhrel, B.R. ; Posik, Matthew ; Protzman, Tristan ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Qin, Zhi ; Qiu, Hao ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, Nandita ; Ray, Lanny ; Ritter, Hans Georg ; Robertson, Charles ; Rogachevskiy, Oleg ; Rosales Aguilar, Manuel ; Roy, Diptanil ; Ruan, Lijuan ; Sahoo, Aswini ; Sahoo, Nihar Ranjan ; Sako, Hiroyuki ; Salur, Sevil ; Samigullin, Edward ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Seger, Janet ; Seto, Richard ; Seyboth, Peter ; Shah, Neha ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, Tianhao ; Sharma, Mahima ; Sharma, Natasha ; Sharma, Rishabh ; Sharma, Sharang Rav ; Sheikh, Ashik Ikbal ; Shen, D. ; Shen, D.Y. ; Shen, Kaifeng ; Shi, Shusu ; Shi, Yingying ; Shou, Qiye ; Si, Fan ; Singh, Jagbir ; Singha, Subhash ; Sinha, Priyanshi ; Skoby, Michael J. ; Soehngen, Yannick ; Song, Youqi ; Srivastava, Brijesh ; Stanislaus, Shirvel ; Stewart, David ; Strikhanov, Mikhail ; Stringfellow, Blair ; Su, Yuan ; Sun, Chuan ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry ; Sweger, Zachary W. ; Tamis, Andrew ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terry ; Thomas, James H. ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Michael ; Tomkiel, Catherine ; Trentalange, Steven ; Tribble, Robert ; Tribedy, Prithwish ; Tsai, Oleg D. ; Tsang, Chun Yuen ; Tu, Zhoudunming ; Tyler, Jace ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vasiliev, Alexander ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, Fuqiang ; Wang, Gang ; Wang, J.S. ; Wang, J. ; Wang, Xiaofeng ; Wang, Y. ; Wang, Y. ; Wang, Y. ; Wang, Zhen ; Webb, Jason ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wieman, Howard ; Wilks, Gavin ; Wissink, Scott ; Wu, J. ; Wu, J. ; Wu, Xiao ; Wu, Xiao ; Wu, Yang ; Xi, Baoshan ; Xiao, Zhigang ; Xie, Guannan ; Xie, Wei ; Xu, Haojie ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, Gaoguo ; Yan, Zhengxi ; Yang, Chi ; Yang, Qian ; Yang, Shuai ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, Kin ; Yu, Y. ; Zha, Wangmei ; Zhang, ChunJian ; Zhang, Dingwei ; Zhang, Jinlong ; Zhang, Shenghui ; Zhang, Wei ; Zhang, Xin ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Z. ; Zhang, Z. ; Zhao, Fengyi ; Zhao, Jie ; Zhao, Minghui ; Zhou, Chensheng ; Zhou, Jian ; Zhou, Shuai ; Zhou, Yingjie ; Zhu, Xianglei ; Żurek, Maria Katarzyna ; Zyzak, Maksym
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
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