Refine
Year of publication
Document Type
- Preprint (678)
- Article (608)
- Working Paper (5)
- Book (2)
- Review (1)
Has Fulltext
- yes (1294)
Is part of the Bibliography
- no (1294)
Keywords
- Heavy Ion Experiments (20)
- SARS-CoV-2 (12)
- Hadron-Hadron Scattering (11)
- Hadron-Hadron scattering (experiments) (11)
- LHC (9)
- Heavy-ion collision (6)
- prostate cancer (6)
- COVID-19 (5)
- COVID19-NMR (5)
- radical prostatectomy (5)
- ALICE experiment (4)
- Atmospheric chemistry (4)
- Collective Flow (4)
- Genetics (4)
- Jets (4)
- Quark-Gluon Plasma (4)
- Solution NMR spectroscopy (4)
- Solution NMR-spectroscopy (4)
- 5′-UTR (3)
- ALICE (3)
- Covid19-NMR (3)
- Heavy Ions (3)
- Immunology (3)
- Jets and Jet Substructure (3)
- Non-structural protein (3)
- Oncology (3)
- Pandemic (3)
- Seizure (3)
- chemotherapy (3)
- immunohistochemistry (3)
- pp collisions (3)
- systematic biopsy (3)
- ADHD (2)
- Beauty production (2)
- Bipolar disorder (2)
- Charm physics (2)
- Cochlear implant (2)
- Corona (2)
- Depression (2)
- Diagnosis (2)
- Digitalisierung (2)
- Digitization (2)
- EWSR1 (2)
- Epileptischer Anfall (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- FFLU (2)
- Fahrradmitnahme (2)
- Fahrradverleihsysteme (2)
- Gene fusion (2)
- Heavy Quark Production (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Liver transplantation (2)
- NMR spectroscopy (2)
- PD-L1 (2)
- PSA (2)
- Pandemie (2)
- Particle Correlations and Fluctuations (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- Protein drugability (2)
- Psychiatric disorders (2)
- QCD (2)
- RNA (2)
- SARS-CoV‑2 (2)
- Single electrons (2)
- Status epilepticus (2)
- Survival analysis (2)
- concordance (2)
- drug resistance (2)
- epidemiology (2)
- fMRI (2)
- fusion biopsy (2)
- immunotherapy (2)
- lung cancer (2)
- nutlin-3 (2)
- p53 (2)
- survival (2)
- targeted therapy (2)
- 19F (1)
- 3Cs technology (1)
- 5'-UTR (1)
- 5_SL4 (1)
- 900 GeV (1)
- ABCB1 (1)
- ABCC1 (1)
- ACLF (1)
- AKI (1)
- AKT (1)
- ALICE detector (1)
- ASAP (1)
- Active middle ear implants (1)
- Acute HIV infection (1)
- Adults (1)
- Aedes aegypti (1)
- Agoraphobia (1)
- Amino acid analysis (1)
- Animal model (1)
- Anti-nuclei (1)
- Anti-seizure medication (1)
- Antifungal agents (1)
- Aortic valve replacement (1)
- Artificial Intelligence (1)
- Aspergillosis (1)
- Atmospheric science (1)
- Auditory system (1)
- Awareness campaign (1)
- Ayurveda (1)
- B cell malignancies (1)
- B cell receptor (1)
- BCOR (1)
- BCORL1 (1)
- BEACOPP (1)
- BI1361849 (1)
- BMI (1)
- BPH (1)
- BPO (1)
- BPTF (1)
- Behavior (1)
- Bike and Ride / Fahrrad-Abstellanlagen (1)
- Bilateral cochlear implant (1)
- Biodiversity (1)
- Biodiversity Data (1)
- Biogeochemistry (1)
- Biological heart valves (1)
- Biological markers (1)
- Biomarker (1)
- Biomarkers (1)
- Biomonitoring (1)
- Biophysical models (1)
- Bioprosthesis (1)
- Bone conduction devices (1)
- Bone tumor (1)
- Boosted Jets (1)
- Botanical Collections (1)
- Brain (1)
- Brain tumor (1)
- Built environment (1)
- Business strategy in drug development (1)
- CD47 (1)
- CLIF-C ACLF score (1)
- CLIF-C ACLF-R score (1)
- CLOUD experiment (1)
- COMT (1)
- COVID (1)
- CRPC (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CTLA-4 (1)
- CV9202 (1)
- Calcium signalling (1)
- Cancer (1)
- Cancer check up (1)
- Cancer genomics (1)
- Cancer treatment (1)
- Cardiac surgery (1)
- Carotid injury (1)
- Cell membranes (1)
- Centrality Class (1)
- Centrality Selection (1)
- Chemical composition (1)
- Chemokine CCL2 (1)
- Chemokines (1)
- Child abuse (1)
- Climate change (1)
- Climate-change impacts (1)
- Clinical Trials and Observations (1)
- Clinical genetics (1)
- Clinical practice guidelines (1)
- Clinical trial (1)
- Clinical variation (1)
- Collective Flow, (1)
- Combo® DTS (1)
- Compact city (1)
- Comparison with QCD (1)
- Complex decongestive therapy (1)
- Complication (1)
- Complications (1)
- Computed axial tomography (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer-aided drug design (1)
- Congenital anomalies (1)
- Consensus statement (1)
- Conservation (1)
- Conservation biology (1)
- Course (1)
- Course evaluation (1)
- Covid19-nmr (1)
- Crispr/Cas (1)
- Culex pipiens (1)
- Cycle streets (1)
- DNA sequence analysis (1)
- DNA-PAINT (1)
- DUBs (1)
- Decision Making und Risk (1)
- Demolition emissions (1)
- Design functions (1)
- Diagnostic markers (1)
- Dimerization domain (1)
- Direct reactions (1)
- Distance learning (1)
- Distanzunterricht (1)
- Doxorubicin (1)
- Drug screens (1)
- Drug therapy (1)
- D’Amico classification (1)
- EGFR (1)
- EP300 (1)
- Ecotoxicology (1)
- Elderly (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Elliptic flow (1)
- Embryos (1)
- Environment perception (1)
- Environmental Chemistry (1)
- Environmental impact (1)
- Epilepsy (1)
- Eurasian Curlew (1)
- Europe (1)
- Everolimus (1)
- Extended donor criteria (1)
- FBS (1)
- FGFR (1)
- FOXO1 (1)
- Fahrrad & ÖV (1)
- Fahrradabstellanalgen (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- Financial Markets (1)
- Forschung (1)
- Frailty (1)
- Functional outcomes (1)
- GPS collar (1)
- Gene expression (1)
- Gene regulation (1)
- General practitioners (1)
- Gleason Score (1)
- Gleason score (1)
- Gleason upgrading (1)
- Global positioning system (1)
- Global warming (1)
- Graft function (1)
- Graft survival (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- HBT (1)
- HIV (1)
- HNO (1)
- HOLEP (1)
- HSP (hereditary spastic paraplegia) (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hard Scattering (1)
- Head bandage (1)
- Health care workers (1)
- Health policy (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Hematologic malignancies (1)
- Hematology (1)
- Hepatocellular carcinoma (1)
- Herbaria (1)
- HoLEP (1)
- Holmium laser enucleation (1)
- Hypertension (1)
- Hypofractionated radiotherapy (1)
- IAP (1)
- IFN (1)
- IHC (1)
- IPSS (1)
- Imaging genetics (1)
- Immune suppression (1)
- Immunogenetics (1)
- Immunomonitoring (1)
- Incidental prostate cancer (1)
- Inclusive spectra (1)
- Inflammation (1)
- Insurance (1)
- Integrated urban planning (1)
- Integrierte Stadtentwicklung (1)
- Integrierte kommunale Strategien (1)
- Intensity interferometry (1)
- Intermodalität (1)
- Invariant Mass Distribution (1)
- Invasive candidiasis (1)
- Ionisation energy loss (1)
- Jet Physics (1)
- Jet Substructure (1)
- KDIGO (1)
- KLHL11 (1)
- Kidney (1)
- Kompakte Stadt (1)
- Lafora disease (1)
- Lee type, functional outcome (1)
- Lehre (1)
- Lehrveranstaltungsevaluation (1)
- Leukemias (1)
- Library screening (1)
- Lipedema (1)
- Liposuction (1)
- Literature review (1)
- Liver diseases (1)
- Luciferase (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- MDM2 (1)
- MN1 (1)
- MR-proADM (1)
- Machine learning (1)
- Macrodomain (1)
- Macrozoobenthos (1)
- Magnet dislocation (1)
- Magnetic resonance imaging (1)
- Marginal grafts (1)
- Marketing & Kommunikation (1)
- Material budget (1)
- Medical education (1)
- Medical history (1)
- Medizinstudium (1)
- Mental health and psychiatry (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methodenstudie (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Mixed hearing loss (1)
- Mobility design (1)
- Mobilität (1)
- Mobilität in Deutschland (1)
- Mobilitätskennziffern (1)
- Mobilitätspanel (1)
- Molecular subtypes (1)
- Monte Carlo (1)
- Mortality (1)
- Multi-Parton Interactions (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Mutation databases (1)
- Mycoses (1)
- Myeloid Neoplasia (1)
- N471D strumpellin knock-in mice (1)
- NADPH oxidase (1)
- NPSR1 (1)
- NURF (1)
- NVBP (1)
- Nachhaltige Stadtentwicklung (1)
- Nephrons (1)
- Neural network (1)
- Neuroepithelial (1)
- Neuroepithelial tumor (1)
- Neurooncology (1)
- Neuroscience (1)
- Nivolumab (1)
- Non-motorised travel (1)
- Non-small cell lung cancer (1)
- Non-small-cell lung cancer (1)
- Non–small-cell lung cancer (1)
- Nox4 (1)
- Nuclear modification factor (1)
- Nuclear reactions (1)
- Nuclear structure & decays (1)
- Nucleic acid-binding domain (1)
- Nucleocapsid (1)
- Nucleon induced nuclear reactions (1)
- Numenius arquata (1)
- OD approach (1)
- OR time (1)
- ORL (1)
- ORP (1)
- Observational study (1)
- Oldest-old (1)
- Online Survey (1)
- Organ rinse (1)
- Organ shortage (1)
- Otorhinolaryngological (1)
- Otorhinolaryngology (1)
- Outcome (1)
- Overall survival (1)
- Oxygen (1)
- PAD-test (1)
- PATZ1 (1)
- PCR (1)
- PCV (1)
- PD-1 (1)
- PLAGL1 (1)
- PM10 (1)
- PSA screening (1)
- PSA-Screening (1)
- PYTHIA (1)
- Panic disorder (1)
- Particle and Resonance Production (1)
- Pb–Pb (1)
- Pediatric (1)
- Personenmobilität (1)
- Phase 3 (1)
- Phosphorylation (1)
- Post-traumatic stress disorder (1)
- Preventive medicine (1)
- Production Cross Section (1)
- Prognostic markers (1)
- Properties of Hadrons (1)
- Prostata-specific antigen (1)
- Prostataspezifisches Antigen (1)
- Prostate cancer (1)
- Prostatic neoplasms (1)
- Protein druggability (1)
- Proton–proton (1)
- Prävention (1)
- Psychological and psychosocial issues (1)
- Psychology (1)
- Quality of life (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Quarkonium (1)
- RARP (1)
- RITA (1)
- RNA genome (1)
- Rabbit (1)
- Radiation exposure (1)
- Radical nephrectomy (1)
- Radical prostatectomy (1)
- Radiofrequency ablation (1)
- Randomisation (1)
- Rapid diagnostic test (1)
- Rapidity Range (1)
- Raumstruktur (1)
- Reactive oxygen species (1)
- Real-world data (1)
- Region Rhein-Main (1)
- Registry (1)
- Rehabilitation (1)
- Relativistic heavy ion physics (1)
- Relativistic heavy-ion collisions (1)
- Renal cancer (1)
- Renal system (1)
- Research (1)
- Research Infrastructure (1)
- Research funding (1)
- Residency (1)
- Resolution Parameter (1)
- Restenosis (1)
- Rhabdomyoma (1)
- SARS-CoV‑2 pandemic (1)
- SARS-CoV‑2-Pandemie (1)
- SAVI (1)
- SIRPalpha (1)
- SL1 (1)
- SL5a (1)
- SL5b (1)
- SL5b + c (1)
- SL5c (1)
- SMAD (1)
- SOFA (1)
- SPG8 (1)
- STING (1)
- Semantics (1)
- Sepsis (1)
- Septic shock (1)
- Sequential (1)
- Seroconverter (1)
- Shared space (1)
- Shell model (1)
- Simultaneous (1)
- Single muons (1)
- Single-cell RNA sequencing (1)
- Size distribution (1)
- Small molecules (1)
- Small-cell lung cancer (1)
- Specialist training (1)
- Spectroscopic factors & electromagnetic moments (1)
- Stadtplanung (1)
- Stechmückenfalle (1)
- Stegomyia aegypti (1)
- Streams (1)
- Street design (1)
- Structural protein (1)
- Supratentorial (1)
- Surgery (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Sustainable urban development (1)
- Systematic Uncertainty (1)
- TGFβ (1)
- TR (1)
- TUR-P (1)
- Tacrolimus (1)
- Taxonomy (1)
- Teaching (1)
- Technical data (1)
- Temperature preference (1)
- Thermodynamics (1)
- Time Projection Chamber (1)
- Tools and ressources (1)
- Total operating room time (1)
- Tracking (1)
- Traditional Indian Medicine (1)
- Transcriptome analysis (1)
- Transition radiation detector (1)
- Transportation planning (1)
- Transurethral resection of the prostate (1)
- Transverse momentum (1)
- Travel behaviour (1)
- Treatment (1)
- Trigger (1)
- Tumor heterogeneity (1)
- Tumor therapy (1)
- Tumour biomarkers (1)
- Ultrafine particles (1)
- University hospitals (1)
- Universitätskliniken (1)
- Upper Rhine Valley (1)
- Urban aerosol (1)
- Urban planning (1)
- Urban space (1)
- Urinary continence (1)
- Urinary incontinence (1)
- Ursus arctos (1)
- VX-2 (1)
- Vector Boson Production (1)
- Verkehr (1)
- Verkehrsplanung (1)
- Vesicles (1)
- Volmer–Weber growth (1)
- Vorsorgeuntersuchung (1)
- WASH complex subunit 5 (1)
- Weiterbildung (1)
- Westphal-Paradigm (1)
- X-ray powder diffraction (1)
- Xenon-based gas mixture (1)
- YM155 (1)
- accessory proteins (1)
- accident (1)
- activity sensors (1)
- acute myeloid leukemia (1)
- acute-on-chronic liver failure (1)
- adult (1)
- aerosol formation (1)
- aerosols (1)
- aggression (1)
- anti-EGFR therapy (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antiviral therapy (1)
- arthritis (1)
- artifacts (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- atypical EGFR mutations (1)
- bicycle use (1)
- bioactivity testing (1)
- biogeographic legaciese (1)
- biomarker (1)
- biopsy (1)
- biopsy naïve (1)
- blood loss (1)
- brown bear (1)
- car use reduction (1)
- castration resistance (1)
- catheter removal (1)
- cell biology (1)
- cell lines (1)
- cell-free protein synthesis (1)
- cerebrospinal fluid (1)
- chemorefractory metastatic colorectal cancer (1)
- chemoresistance (1)
- cholangiocarcinoma (1)
- chronic total occlusion (1)
- cirrhosis (1)
- clinical practice (1)
- clinical trial (1)
- clinical trials (1)
- cluttering (1)
- complementary medicine (1)
- complexity (1)
- complications (1)
- consensus (1)
- coronavirus (1)
- correlation (1)
- cycle streets (1)
- cytotoxic T cells (1)
- dE/dx (1)
- data management (1)
- data quality (1)
- death rates (1)
- deferred treatment (1)
- delayed treatment (1)
- denisovite (1)
- detector (1)
- diffuse low-grade glioma (1)
- diffusion-weighted magnetic resonance imaging (1)
- digitale Vernetzung (1)
- disease prevalence (1)
- disorder (1)
- downgrading (1)
- early continence (1)
- easyPACId (1)
- ectosomes (1)
- electroencephalography (EEG) (1)
- electron crystallography (1)
- electron diffraction tomography (1)
- electronic diaries (1)
- enterobacter infections; pseudomonas aeruginosa; epidemiology (1)
- epilepsy (1)
- exosomes (1)
- experimental results (1)
- extracellular vesicles (1)
- fibrous materials (1)
- fluorine (1)
- forest classification (1)
- forest functional similarity (1)
- fragment screening (1)
- fragment-based screening (1)
- framework-structured solids (1)
- gRNA library (1)
- gene therapy (1)
- genetics (1)
- genetics and genomics (1)
- genome-wide (1)
- guidelines (1)
- haemophilia treatment (1)
- head-and-neck cancer (1)
- heavy ion experiments (1)
- histological outcomes (1)
- histopathological growth pattern (1)
- human (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- infection (1)
- injury (1)
- inorganic materials (1)
- integrative medicine (1)
- interaction effect (1)
- interim positron emissiontomography (1)
- interoperability (1)
- interstitial lung disease (1)
- intrinsically disordered region (1)
- inverse stage migration (1)
- irritable bowel syndrome (1)
- juvenile myoclonic epilepsy (1)
- layer-by-layer (LbL) (1)
- level-specific model fit (1)
- likelihood ratio test (1)
- liver (1)
- liver metastasis (1)
- liver transplantation (1)
- lockdown (1)
- loss-of-function (1)
- low-dose imaging (1)
- mRNA active cancer immunotherapy (1)
- mTOR (1)
- mTOR inhibitor (1)
- magnetic resonance imaging (1)
- maternal care (1)
- mechanical ventilation (1)
- medical risk factors (1)
- medulloblastoma (1)
- metal–organic frameworks (1)
- metastasis (1)
- metastatic prostate cancer (1)
- microparticles (1)
- microsatellite instability (1)
- microvesicles (1)
- minerals (1)
- minimal information requirements (1)
- modularity (1)
- morbidity (1)
- mortality (1)
- mosquito trap (1)
- mpMRI (1)
- multicenter study (1)
- multilevel structural equation modeling (1)
- multiplexed immunofluorescence (1)
- multivariate mixed model (1)
- myositis (1)
- nanocrystalline materials (1)
- nanoparticle growth (1)
- nanoscience (1)
- nanostructure (1)
- natural products (1)
- neoadjuvant chemoradiotherapy (1)
- nerve-sparing (1)
- neuroblastoma (1)
- neurovascular bundle preservation (1)
- nitro-fatty acids (1)
- nodular lymphocyte-predominant Hodgkin lymphoma (1)
- non-small-cell lung cancer (1)
- nonstructural proteins (1)
- nutrition - clinical (1)
- optical coherence tomography (1)
- oral cavity cancer (1)
- organic thin films (1)
- p53 activator (1)
- palmitoylation (1)
- pediatric intensive care (1)
- penile cancer (1)
- peri-implantitis (1)
- perioperative outcome (1)
- personality (1)
- pharmacoresistance (1)
- phylogenetic community distance (1)
- polytypism (1)
- predictive biomarker (1)
- prognosis (1)
- progressive myoclonus epilepsy (1)
- prostate neoplasm (1)
- prostate volume (1)
- prostate-specific antigen (1)
- proteins (1)
- proteobacteria (1)
- proteomics (1)
- pseudomonas aeruginosa (1)
- pulmonary failure (1)
- quark gluon plasma (1)
- radiation (1)
- radical prostatecomy (1)
- radiotherapy (1)
- randomized (1)
- re-exposure (1)
- reactive oxygen species (1)
- rechallenge (1)
- reintroduction (1)
- repeat biopsy (1)
- repeatability (1)
- reproducibility (1)
- resilience (1)
- respiratory failure (1)
- rigor (1)
- risk factors (1)
- risk stratification (1)
- robust test statistic (1)
- satellite telemetry (1)
- schizophrenia (1)
- secondary data analysis (1)
- selenolates (1)
- self-assembled monolayers (1)
- sepsis (1)
- simplified production (1)
- single subject classification (1)
- smart home (1)
- smart living (1)
- spectra (1)
- stage-based models (1)
- standardization (1)
- structural proteins (1)
- strumpellin (1)
- stuttering (1)
- subgrouping (1)
- surface chemistry (1)
- surface-mounted metal–organic frameworks (SURMOFs) (1)
- surgical margin (1)
- survivin (1)
- sustainable travel (1)
- targeted biopsy (1)
- temozolomide (1)
- temporal classification (1)
- thiolates (1)
- transrectal prostate biopsy (1)
- trauma (1)
- travel behavior change (1)
- treatment centres (1)
- treatment resistance (1)
- triptycene (1)
- tropical forests (1)
- tumor microenvironment (1)
- tumor weight (1)
- tyrosine kinase inhibitor (TKI) (1)
- upgrading (1)
- uveal melanoma (1)
- ventral striatum (1)
- volatile organic compounds (1)
- waiting time (1)
- web of things (1)
- Öffentlichkeit (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (1060)
- Frankfurt Institute for Advanced Studies (FIAS) (955)
- Informatik (923)
- Medizin (123)
- Geowissenschaften (42)
- Biowissenschaften (13)
- Biochemie, Chemie und Pharmazie (11)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (8)
- Geographie (7)
- Geowissenschaften / Geographie (7)
Highlights:
• Evaluation of three cycle street designs by means of visualisation assessments.
• Shared space is evaluated as the safest and most attractive cycle street design.
• The conventional urban street design is perceived as the most clearly structured.
• Affinity towards walking and cycling favours a positive evaluation of shared space.
Abstract
Cycle streets have been implemented in many urban areas around the world in recent years to make cycling safer and more attractive. In these streets, cyclists have priority over motorised traffic. They are allowed to use the entire roadway and determine traffic speed. However, there have been no standardised design guidelines for cycle streets to date. Moreover, there is limited understanding of the individual perception of different cycle street designs. Yet, positive evaluations of safety and attractiveness are especially important for pleasant travel in public spaces. Therefore, this study examines the individual perceptions of three cycle street designs: conventional, flow and shared space. Visualisations of these designs were implemented in a written household survey conducted in the urban Rhine-Main metropolitan region in Germany (n = 701). Participants were asked to assess the different designs in terms of safety, clarity, attractiveness and fun. Furthermore, bivariate analyses and regression models were performed to investigate whether individual travel preferences and attitudes, regular mode use and socio-demographic characteristics affect assessments of the designs. The results show that the shared space design is rated as the safest, most attractive and most fun. The conventional cycle street is evaluated as the most clearly structured. Individual affinity towards cycling and walking favours a good evaluation of the shared space design, while a high car affinity and having a migrant background positively affect the assessment of the conventional design. In addition, younger participants and members of households without a car assess the flow design more favourably.
Background and Aims: In patients with Rat sarcoma proto-oncogene (RAS) wild-type metastatic colorectal cancer (mCRC), anti-epidermal growth factor receptor (EGFR) antibodies have been established in first- and further therapy lines. Due to limited treatment options upon disease progression, anti-EGFR re-exposure is increasingly employed in real-world oncology. The aim of this study was to assess clinical implementation and utility of anti-EGFR retreatment strategies in real-world mCRC patients. Methods: In this monocentric retrospective study, we included 524 patients with CRC and identified patients who received an anti-EGFR-based treatment as well as anti-EGFR rechallenge (progression on first-line anti-EGFR therapy) or reintroduction (discontinuation due to intolerance/toxicity/other). Results: In total, 143 patients received an anti-EGFR-based first- or second-line treatment, showing a similar overall survival (OS) compared to the non-anti-EGFR treatment group (38.3 vs. 39.6 months, p = 0.88). Thirty-three patients met the inclusion criteria for anti-EGFR re-exposure and were either assigned to rechallenge (n = 21) or reintroduction (n = 12) subgroups. The median FU after re-exposure was 45.8 months. Cetuximab and Panitumumab were used in 21 and 12 patients, respectively, and the main chemotherapy at re-exposure was FOLFIRI in 39.4%. Anti-EGFR re-exposure was associated with a distinct trend towards a better outcome (median OS 56.0 vs. 35.4 months, p = 0.06). In a subgroup comparison, reintroduction was associated with a higher OS and PFS in trend compared to the rechallenge (mOS 66 vs. 52.4, n.s., mPFS 7.33 vs. 3.68 months, n.s.). Conclusions: This retrospective study provides real-world evidence underscoring that anti-EGFR re-exposure strategies might benefit patients independently of the reason for prior discontinuation.
Purpose: To test the effect of anatomic variants of the prostatic apex overlapping the membranous urethra (Lee type classification), as well as median urethral sphincter length (USL) in preoperative multiparametric magnetic resonance imaging (mpMRI) on the very early continence in open (ORP) and robotic-assisted radical prostatectomy (RARP) patients. Methods: In 128 consecutive patients (01/2018–12/2019), USL and the prostatic apex classified according to Lee types A–D in mpMRI prior to ORP or RARP were retrospectively analyzed. Uni- and multivariable logistic regression models were used to identify anatomic characteristics for very early continence rates, defined as urine loss of ≤ 1 g in the PAD-test. Results: Of 128 patients with mpMRI prior to surgery, 76 (59.4%) underwent RARP vs. 52 (40.6%) ORP. In total, median USL was 15, 15 and 10 mm in the sagittal, coronal and axial dimensions. After stratification according to very early continence in the PAD-test (≤ 1 g vs. > 1 g), continent patients had significantly more frequently Lee type D (71.4 vs. 54.4%) and C (14.3 vs. 7.6%, p = 0.03). In multivariable logistic regression models, the sagittal median USL (odds ratio [OR] 1.03) and Lee type C (OR: 7.0) and D (OR: 4.9) were independent predictors for achieving very early continence in the PAD-test. Conclusion: Patients’ individual anatomical characteristics in mpMRI prior to radical prostatectomy can be used to predict very early continence. Lee type C and D suggest being the most favorable anatomical characteristics. Moreover, longer sagittal median USL in mpMRI seems to improve very early continence rates.
The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies, including systemic lupus erythematosus (SLE), Aicardi–Goutières syndrome (AGS), and stimulator of IFN genes-associated vasculopathy with onset in infancy (SAVI). The involvement of STING in these diseases points to an unmet need for the development of agents that inhibit STING signaling. Here, we report that endogenously formed nitro-fatty acids can covalently modify STING by nitro-alkylation. These nitro-alkylations inhibit STING palmitoylation, STING signaling, and subsequently, the release of type I IFN in both human and murine cells. Furthermore, treatment with nitro-fatty acids was sufficient to inhibit production of type I IFN in fibroblasts derived from SAVI patients with a gain-of-function mutation in STING. In conclusion, we have identified nitro-fatty acids as endogenously formed inhibitors of STING signaling and propose for these lipids to be considered in the treatment of STING-dependent inflammatory diseases.
Background: To evaluate the impact of time to castration resistance (TTCR) in metastatic hormone-sensitive prostate cancer (mHSPC) patients on overall survival (OS) in the era of combination therapies for mHSPC.
Material and Methods: Of 213 mHSPC patients diagnosed between 01/2013-12/2020 who subsequently developed metastatic castration resistant prostate cancer (mCRPC), 204 eligible patients were analyzed after having applied exclusion criteria. mHSPC patients were classified into TTCR <12, 12-18, 18-24, and >24 months and analyzed regarding OS. Moreover, further OS analyses were performed after having developed mCRPC status according to TTCR. Logistic regression models predicted the value of TTCR on OS.
Results: Median follow-up was 34 months. Among 204 mHSPC patients, 41.2% harbored TTCR <12 months, 18.1% for 12-18 months, 15.2% for 18-24 months, and 25.5% for >24 months. Median age was 67 years and median PSA at prostate cancer diagnosis was 61 ng/ml. No differences in patient characteristics were observed (all p>0.05). According to OS, TTCR <12 months patients had the worst OS, followed by TTCR 12-18 months, 18-24 months, and >24 months, in that order (p<0.001). After multivariable adjustment, a 4.07-, 3.31-, and 6.40-fold higher mortality was observed for TTCR 18-24 months, 12-18 months, and <12 months patients, relative to TTCR >24 months (all p<0.05). Conversely, OS after development of mCRPC was not influenced by TTCR stratification (all p>0.05).
Conclusion: Patients with TTCR <12 months are at the highest OS disadvantage in mHSPC. This OS disadvantage persisted even after multivariable adjustment. Interestingly, TTCR stratified analyses did not influence OS in mCRPC patients.
Ependymomas encompass a heterogeneous group of central nervous system (CNS) neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-)genomic profiling efforts have identified several molecular groups of ependymoma that are characterized by distinct molecular alterations and/or patterns. Based on unsupervised visualization of a large cohort of genome-wide DNA methylation data, we identified a highly distinct group of pediatric-type tumors (n = 40) forming a cluster separate from all established CNS tumor types, of which a high proportion were histopathologically diagnosed as ependymoma. RNA sequencing revealed recurrent fusions involving the pleomorphic adenoma gene-like 1 (PLAGL1) gene in 19 of 20 of the samples analyzed, with the most common fusion being EWSR1:PLAGL1 (n = 13). Five tumors showed a PLAGL1:FOXO1 fusion and one a PLAGL1:EP300 fusion. High transcript levels of PLAGL1 were noted in these tumors, with concurrent overexpression of the imprinted genes H19 and IGF2, which are regulated by PLAGL1. Histopathological review of cases with sufficient material (n = 16) demonstrated a broad morphological spectrum of tumors with predominant ependymoma-like features. Immunohistochemically, tumors were GFAP positive and OLIG2- and SOX10 negative. In 3/16 of the cases, a dot-like positivity for EMA was detected. All tumors in our series were located in the supratentorial compartment. Median age of the patients at the time of diagnosis was 6.2 years. Median progression-free survival was 35 months (for 11 patients with data available). In summary, our findings suggest the existence of a novel group of supratentorial neuroepithelial tumors that are characterized by recurrent PLAGL1 fusions and enriched for pediatric patients.
The objective of the study was to test the impact of implementing standard full functional-length urethral sphincter (FFLU) and neurovascular bundle preservation (NVBP) with intraoperative frozen section technique (IFT) on long-term urinary continence in patients undergoing robotic-assisted radical prostatectomy (RARP). We relied on an institutional tertiary-care database to identify patients who underwent RARP between 01/2014 and 09/2019. Until 10/2017, FFLU was not performed and decision for NVBP was taken without IFT. From 11/2017, FFLU and IFT-guided NVBP was routinely performed in all patients undergoing RARP. Long-term continence (≥ 12 months) was defined as the usage of no or one safety- pad. Uni- and multivariable logistic regression models tested the correlation between surgical approach (standard vs FFLU + NVBP) and long-term continence. Covariates consisted of age, body mass index, prostate volume and extraprostatic extension of tumor. The study cohort consisted of 142 patients, with equally sized groups for standard vs FFLU + NVBP RARP (68 vs 74 patients). Routine FFLU + NVBP implementation resulted in a long-term continence rate of 91%, compared to 63% in standard RARP (p < 0.001). Following FFLU + NVBP RARP, 5% needed 1–2, 4% 3–5 pads/24 h and no patient (0%) suffered severe long-term incontinence (> 5 pads/24 h). No significant differences in patient or tumor characteristics were recorded between both groups. In multivariable logistic regression models, FFLU + NVBP was a robust predictor for continence (Odds ratio [OR]: 7.62; 95% CI 2.51–27.36; p < 0.001). Implementation of FFLU and NVBP in patients undergoing RARP results in improved long-term continence rates of 91%.
Methodik
(2002)
Die vegetationskundliche und strukturelle Zuordnung der Lebensraumtypen erfolgt nach der vorrangig von Braun-Blanquet entwickelten Vegetationsklassifizierung, einer hierarchischen Gliederung der Vegetationstypen (Syntaxonomie), die die Ebenen der Assoziation, des Verbandes, der Ordnung und der Klasse umfasst. Hierbei ist die Assoziation die grundlegende Einheit, in der die Pflanzengesellschaften zusammengefasst werden, die sich durch gleiche charakteristische Arten(gruppen)kombinationen auszeichnen. Der Verband vereinigt ähnliche Assoziationen. Das sind bereits umfassendere, jedoch standörtlich noch recht einheitliche Vegetationseinheiten. In Ordnungen werden ähnliche Verbände zusammengefasst. Die Klasse vereinigt ähnliche Ordnungen.