Refine
Year of publication
Document Type
- Preprint (678)
- Article (608)
- Working Paper (5)
- Book (2)
- Review (1)
Has Fulltext
- yes (1294)
Is part of the Bibliography
- no (1294)
Keywords
- Heavy Ion Experiments (20)
- SARS-CoV-2 (12)
- Hadron-Hadron Scattering (11)
- Hadron-Hadron scattering (experiments) (11)
- LHC (9)
- Heavy-ion collision (6)
- prostate cancer (6)
- COVID-19 (5)
- COVID19-NMR (5)
- radical prostatectomy (5)
- ALICE experiment (4)
- Atmospheric chemistry (4)
- Collective Flow (4)
- Genetics (4)
- Jets (4)
- Quark-Gluon Plasma (4)
- Solution NMR spectroscopy (4)
- Solution NMR-spectroscopy (4)
- 5′-UTR (3)
- ALICE (3)
- Covid19-NMR (3)
- Heavy Ions (3)
- Immunology (3)
- Jets and Jet Substructure (3)
- Non-structural protein (3)
- Oncology (3)
- Pandemic (3)
- Seizure (3)
- chemotherapy (3)
- immunohistochemistry (3)
- pp collisions (3)
- systematic biopsy (3)
- ADHD (2)
- Beauty production (2)
- Bipolar disorder (2)
- Charm physics (2)
- Cochlear implant (2)
- Corona (2)
- Depression (2)
- Diagnosis (2)
- Digitalisierung (2)
- Digitization (2)
- EWSR1 (2)
- Epileptischer Anfall (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- FFLU (2)
- Fahrradmitnahme (2)
- Fahrradverleihsysteme (2)
- Gene fusion (2)
- Heavy Quark Production (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Liver transplantation (2)
- NMR spectroscopy (2)
- PD-L1 (2)
- PSA (2)
- Pandemie (2)
- Particle Correlations and Fluctuations (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- Protein drugability (2)
- Psychiatric disorders (2)
- QCD (2)
- RNA (2)
- SARS-CoV‑2 (2)
- Single electrons (2)
- Status epilepticus (2)
- Survival analysis (2)
- concordance (2)
- drug resistance (2)
- epidemiology (2)
- fMRI (2)
- fusion biopsy (2)
- immunotherapy (2)
- lung cancer (2)
- nutlin-3 (2)
- p53 (2)
- survival (2)
- targeted therapy (2)
- 19F (1)
- 3Cs technology (1)
- 5'-UTR (1)
- 5_SL4 (1)
- 900 GeV (1)
- ABCB1 (1)
- ABCC1 (1)
- ACLF (1)
- AKI (1)
- AKT (1)
- ALICE detector (1)
- ASAP (1)
- Active middle ear implants (1)
- Acute HIV infection (1)
- Adults (1)
- Aedes aegypti (1)
- Agoraphobia (1)
- Amino acid analysis (1)
- Animal model (1)
- Anti-nuclei (1)
- Anti-seizure medication (1)
- Antifungal agents (1)
- Aortic valve replacement (1)
- Artificial Intelligence (1)
- Aspergillosis (1)
- Atmospheric science (1)
- Auditory system (1)
- Awareness campaign (1)
- Ayurveda (1)
- B cell malignancies (1)
- B cell receptor (1)
- BCOR (1)
- BCORL1 (1)
- BEACOPP (1)
- BI1361849 (1)
- BMI (1)
- BPH (1)
- BPO (1)
- BPTF (1)
- Behavior (1)
- Bike and Ride / Fahrrad-Abstellanlagen (1)
- Bilateral cochlear implant (1)
- Biodiversity (1)
- Biodiversity Data (1)
- Biogeochemistry (1)
- Biological heart valves (1)
- Biological markers (1)
- Biomarker (1)
- Biomarkers (1)
- Biomonitoring (1)
- Biophysical models (1)
- Bioprosthesis (1)
- Bone conduction devices (1)
- Bone tumor (1)
- Boosted Jets (1)
- Botanical Collections (1)
- Brain (1)
- Brain tumor (1)
- Built environment (1)
- Business strategy in drug development (1)
- CD47 (1)
- CLIF-C ACLF score (1)
- CLIF-C ACLF-R score (1)
- CLOUD experiment (1)
- COMT (1)
- COVID (1)
- CRPC (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CTLA-4 (1)
- CV9202 (1)
- Calcium signalling (1)
- Cancer (1)
- Cancer check up (1)
- Cancer genomics (1)
- Cancer treatment (1)
- Cardiac surgery (1)
- Carotid injury (1)
- Cell membranes (1)
- Centrality Class (1)
- Centrality Selection (1)
- Chemical composition (1)
- Chemokine CCL2 (1)
- Chemokines (1)
- Child abuse (1)
- Climate change (1)
- Climate-change impacts (1)
- Clinical Trials and Observations (1)
- Clinical genetics (1)
- Clinical practice guidelines (1)
- Clinical trial (1)
- Clinical variation (1)
- Collective Flow, (1)
- Combo® DTS (1)
- Compact city (1)
- Comparison with QCD (1)
- Complex decongestive therapy (1)
- Complication (1)
- Complications (1)
- Computed axial tomography (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer-aided drug design (1)
- Congenital anomalies (1)
- Consensus statement (1)
- Conservation (1)
- Conservation biology (1)
- Course (1)
- Course evaluation (1)
- Covid19-nmr (1)
- Crispr/Cas (1)
- Culex pipiens (1)
- Cycle streets (1)
- DNA sequence analysis (1)
- DNA-PAINT (1)
- DUBs (1)
- Decision Making und Risk (1)
- Demolition emissions (1)
- Design functions (1)
- Diagnostic markers (1)
- Dimerization domain (1)
- Direct reactions (1)
- Distance learning (1)
- Distanzunterricht (1)
- Doxorubicin (1)
- Drug screens (1)
- Drug therapy (1)
- D’Amico classification (1)
- EGFR (1)
- EP300 (1)
- Ecotoxicology (1)
- Elderly (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Elliptic flow (1)
- Embryos (1)
- Environment perception (1)
- Environmental Chemistry (1)
- Environmental impact (1)
- Epilepsy (1)
- Eurasian Curlew (1)
- Europe (1)
- Everolimus (1)
- Extended donor criteria (1)
- FBS (1)
- FGFR (1)
- FOXO1 (1)
- Fahrrad & ÖV (1)
- Fahrradabstellanalgen (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- Financial Markets (1)
- Forschung (1)
- Frailty (1)
- Functional outcomes (1)
- GPS collar (1)
- Gene expression (1)
- Gene regulation (1)
- General practitioners (1)
- Gleason Score (1)
- Gleason score (1)
- Gleason upgrading (1)
- Global positioning system (1)
- Global warming (1)
- Graft function (1)
- Graft survival (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- HBT (1)
- HIV (1)
- HNO (1)
- HOLEP (1)
- HSP (hereditary spastic paraplegia) (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hard Scattering (1)
- Head bandage (1)
- Health care workers (1)
- Health policy (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Hematologic malignancies (1)
- Hematology (1)
- Hepatocellular carcinoma (1)
- Herbaria (1)
- HoLEP (1)
- Holmium laser enucleation (1)
- Hypertension (1)
- Hypofractionated radiotherapy (1)
- IAP (1)
- IFN (1)
- IHC (1)
- IPSS (1)
- Imaging genetics (1)
- Immune suppression (1)
- Immunogenetics (1)
- Immunomonitoring (1)
- Incidental prostate cancer (1)
- Inclusive spectra (1)
- Inflammation (1)
- Insurance (1)
- Integrated urban planning (1)
- Integrierte Stadtentwicklung (1)
- Integrierte kommunale Strategien (1)
- Intensity interferometry (1)
- Intermodalität (1)
- Invariant Mass Distribution (1)
- Invasive candidiasis (1)
- Ionisation energy loss (1)
- Jet Physics (1)
- Jet Substructure (1)
- KDIGO (1)
- KLHL11 (1)
- Kidney (1)
- Kompakte Stadt (1)
- Lafora disease (1)
- Lee type, functional outcome (1)
- Lehre (1)
- Lehrveranstaltungsevaluation (1)
- Leukemias (1)
- Library screening (1)
- Lipedema (1)
- Liposuction (1)
- Literature review (1)
- Liver diseases (1)
- Luciferase (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- MDM2 (1)
- MN1 (1)
- MR-proADM (1)
- Machine learning (1)
- Macrodomain (1)
- Macrozoobenthos (1)
- Magnet dislocation (1)
- Magnetic resonance imaging (1)
- Marginal grafts (1)
- Marketing & Kommunikation (1)
- Material budget (1)
- Medical education (1)
- Medical history (1)
- Medizinstudium (1)
- Mental health and psychiatry (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methodenstudie (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Mixed hearing loss (1)
- Mobility design (1)
- Mobilität (1)
- Mobilität in Deutschland (1)
- Mobilitätskennziffern (1)
- Mobilitätspanel (1)
- Molecular subtypes (1)
- Monte Carlo (1)
- Mortality (1)
- Multi-Parton Interactions (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Mutation databases (1)
- Mycoses (1)
- Myeloid Neoplasia (1)
- N471D strumpellin knock-in mice (1)
- NADPH oxidase (1)
- NPSR1 (1)
- NURF (1)
- NVBP (1)
- Nachhaltige Stadtentwicklung (1)
- Nephrons (1)
- Neural network (1)
- Neuroepithelial (1)
- Neuroepithelial tumor (1)
- Neurooncology (1)
- Neuroscience (1)
- Nivolumab (1)
- Non-motorised travel (1)
- Non-small cell lung cancer (1)
- Non-small-cell lung cancer (1)
- Non–small-cell lung cancer (1)
- Nox4 (1)
- Nuclear modification factor (1)
- Nuclear reactions (1)
- Nuclear structure & decays (1)
- Nucleic acid-binding domain (1)
- Nucleocapsid (1)
- Nucleon induced nuclear reactions (1)
- Numenius arquata (1)
- OD approach (1)
- OR time (1)
- ORL (1)
- ORP (1)
- Observational study (1)
- Oldest-old (1)
- Online Survey (1)
- Organ rinse (1)
- Organ shortage (1)
- Otorhinolaryngological (1)
- Otorhinolaryngology (1)
- Outcome (1)
- Overall survival (1)
- Oxygen (1)
- PAD-test (1)
- PATZ1 (1)
- PCR (1)
- PCV (1)
- PD-1 (1)
- PLAGL1 (1)
- PM10 (1)
- PSA screening (1)
- PSA-Screening (1)
- PYTHIA (1)
- Panic disorder (1)
- Particle and Resonance Production (1)
- Pb–Pb (1)
- Pediatric (1)
- Personenmobilität (1)
- Phase 3 (1)
- Phosphorylation (1)
- Post-traumatic stress disorder (1)
- Preventive medicine (1)
- Production Cross Section (1)
- Prognostic markers (1)
- Properties of Hadrons (1)
- Prostata-specific antigen (1)
- Prostataspezifisches Antigen (1)
- Prostate cancer (1)
- Prostatic neoplasms (1)
- Protein druggability (1)
- Proton–proton (1)
- Prävention (1)
- Psychological and psychosocial issues (1)
- Psychology (1)
- Quality of life (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Quarkonium (1)
- RARP (1)
- RITA (1)
- RNA genome (1)
- Rabbit (1)
- Radiation exposure (1)
- Radical nephrectomy (1)
- Radical prostatectomy (1)
- Radiofrequency ablation (1)
- Randomisation (1)
- Rapid diagnostic test (1)
- Rapidity Range (1)
- Raumstruktur (1)
- Reactive oxygen species (1)
- Real-world data (1)
- Region Rhein-Main (1)
- Registry (1)
- Rehabilitation (1)
- Relativistic heavy ion physics (1)
- Relativistic heavy-ion collisions (1)
- Renal cancer (1)
- Renal system (1)
- Research (1)
- Research Infrastructure (1)
- Research funding (1)
- Residency (1)
- Resolution Parameter (1)
- Restenosis (1)
- Rhabdomyoma (1)
- SARS-CoV‑2 pandemic (1)
- SARS-CoV‑2-Pandemie (1)
- SAVI (1)
- SIRPalpha (1)
- SL1 (1)
- SL5a (1)
- SL5b (1)
- SL5b + c (1)
- SL5c (1)
- SMAD (1)
- SOFA (1)
- SPG8 (1)
- STING (1)
- Semantics (1)
- Sepsis (1)
- Septic shock (1)
- Sequential (1)
- Seroconverter (1)
- Shared space (1)
- Shell model (1)
- Simultaneous (1)
- Single muons (1)
- Single-cell RNA sequencing (1)
- Size distribution (1)
- Small molecules (1)
- Small-cell lung cancer (1)
- Specialist training (1)
- Spectroscopic factors & electromagnetic moments (1)
- Stadtplanung (1)
- Stechmückenfalle (1)
- Stegomyia aegypti (1)
- Streams (1)
- Street design (1)
- Structural protein (1)
- Supratentorial (1)
- Surgery (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Sustainable urban development (1)
- Systematic Uncertainty (1)
- TGFβ (1)
- TR (1)
- TUR-P (1)
- Tacrolimus (1)
- Taxonomy (1)
- Teaching (1)
- Technical data (1)
- Temperature preference (1)
- Thermodynamics (1)
- Time Projection Chamber (1)
- Tools and ressources (1)
- Total operating room time (1)
- Tracking (1)
- Traditional Indian Medicine (1)
- Transcriptome analysis (1)
- Transition radiation detector (1)
- Transportation planning (1)
- Transurethral resection of the prostate (1)
- Transverse momentum (1)
- Travel behaviour (1)
- Treatment (1)
- Trigger (1)
- Tumor heterogeneity (1)
- Tumor therapy (1)
- Tumour biomarkers (1)
- Ultrafine particles (1)
- University hospitals (1)
- Universitätskliniken (1)
- Upper Rhine Valley (1)
- Urban aerosol (1)
- Urban planning (1)
- Urban space (1)
- Urinary continence (1)
- Urinary incontinence (1)
- Ursus arctos (1)
- VX-2 (1)
- Vector Boson Production (1)
- Verkehr (1)
- Verkehrsplanung (1)
- Vesicles (1)
- Volmer–Weber growth (1)
- Vorsorgeuntersuchung (1)
- WASH complex subunit 5 (1)
- Weiterbildung (1)
- Westphal-Paradigm (1)
- X-ray powder diffraction (1)
- Xenon-based gas mixture (1)
- YM155 (1)
- accessory proteins (1)
- accident (1)
- activity sensors (1)
- acute myeloid leukemia (1)
- acute-on-chronic liver failure (1)
- adult (1)
- aerosol formation (1)
- aerosols (1)
- aggression (1)
- anti-EGFR therapy (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antiviral therapy (1)
- arthritis (1)
- artifacts (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- atypical EGFR mutations (1)
- bicycle use (1)
- bioactivity testing (1)
- biogeographic legaciese (1)
- biomarker (1)
- biopsy (1)
- biopsy naïve (1)
- blood loss (1)
- brown bear (1)
- car use reduction (1)
- castration resistance (1)
- catheter removal (1)
- cell biology (1)
- cell lines (1)
- cell-free protein synthesis (1)
- cerebrospinal fluid (1)
- chemorefractory metastatic colorectal cancer (1)
- chemoresistance (1)
- cholangiocarcinoma (1)
- chronic total occlusion (1)
- cirrhosis (1)
- clinical practice (1)
- clinical trial (1)
- clinical trials (1)
- cluttering (1)
- complementary medicine (1)
- complexity (1)
- complications (1)
- consensus (1)
- coronavirus (1)
- correlation (1)
- cycle streets (1)
- cytotoxic T cells (1)
- dE/dx (1)
- data management (1)
- data quality (1)
- death rates (1)
- deferred treatment (1)
- delayed treatment (1)
- denisovite (1)
- detector (1)
- diffuse low-grade glioma (1)
- diffusion-weighted magnetic resonance imaging (1)
- digitale Vernetzung (1)
- disease prevalence (1)
- disorder (1)
- downgrading (1)
- early continence (1)
- easyPACId (1)
- ectosomes (1)
- electroencephalography (EEG) (1)
- electron crystallography (1)
- electron diffraction tomography (1)
- electronic diaries (1)
- enterobacter infections; pseudomonas aeruginosa; epidemiology (1)
- epilepsy (1)
- exosomes (1)
- experimental results (1)
- extracellular vesicles (1)
- fibrous materials (1)
- fluorine (1)
- forest classification (1)
- forest functional similarity (1)
- fragment screening (1)
- fragment-based screening (1)
- framework-structured solids (1)
- gRNA library (1)
- gene therapy (1)
- genetics (1)
- genetics and genomics (1)
- genome-wide (1)
- guidelines (1)
- haemophilia treatment (1)
- head-and-neck cancer (1)
- heavy ion experiments (1)
- histological outcomes (1)
- histopathological growth pattern (1)
- human (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- infection (1)
- injury (1)
- inorganic materials (1)
- integrative medicine (1)
- interaction effect (1)
- interim positron emissiontomography (1)
- interoperability (1)
- interstitial lung disease (1)
- intrinsically disordered region (1)
- inverse stage migration (1)
- irritable bowel syndrome (1)
- juvenile myoclonic epilepsy (1)
- layer-by-layer (LbL) (1)
- level-specific model fit (1)
- likelihood ratio test (1)
- liver (1)
- liver metastasis (1)
- liver transplantation (1)
- lockdown (1)
- loss-of-function (1)
- low-dose imaging (1)
- mRNA active cancer immunotherapy (1)
- mTOR (1)
- mTOR inhibitor (1)
- magnetic resonance imaging (1)
- maternal care (1)
- mechanical ventilation (1)
- medical risk factors (1)
- medulloblastoma (1)
- metal–organic frameworks (1)
- metastasis (1)
- metastatic prostate cancer (1)
- microparticles (1)
- microsatellite instability (1)
- microvesicles (1)
- minerals (1)
- minimal information requirements (1)
- modularity (1)
- morbidity (1)
- mortality (1)
- mosquito trap (1)
- mpMRI (1)
- multicenter study (1)
- multilevel structural equation modeling (1)
- multiplexed immunofluorescence (1)
- multivariate mixed model (1)
- myositis (1)
- nanocrystalline materials (1)
- nanoparticle growth (1)
- nanoscience (1)
- nanostructure (1)
- natural products (1)
- neoadjuvant chemoradiotherapy (1)
- nerve-sparing (1)
- neuroblastoma (1)
- neurovascular bundle preservation (1)
- nitro-fatty acids (1)
- nodular lymphocyte-predominant Hodgkin lymphoma (1)
- non-small-cell lung cancer (1)
- nonstructural proteins (1)
- nutrition - clinical (1)
- optical coherence tomography (1)
- oral cavity cancer (1)
- organic thin films (1)
- p53 activator (1)
- palmitoylation (1)
- pediatric intensive care (1)
- penile cancer (1)
- peri-implantitis (1)
- perioperative outcome (1)
- personality (1)
- pharmacoresistance (1)
- phylogenetic community distance (1)
- polytypism (1)
- predictive biomarker (1)
- prognosis (1)
- progressive myoclonus epilepsy (1)
- prostate neoplasm (1)
- prostate volume (1)
- prostate-specific antigen (1)
- proteins (1)
- proteobacteria (1)
- proteomics (1)
- pseudomonas aeruginosa (1)
- pulmonary failure (1)
- quark gluon plasma (1)
- radiation (1)
- radical prostatecomy (1)
- radiotherapy (1)
- randomized (1)
- re-exposure (1)
- reactive oxygen species (1)
- rechallenge (1)
- reintroduction (1)
- repeat biopsy (1)
- repeatability (1)
- reproducibility (1)
- resilience (1)
- respiratory failure (1)
- rigor (1)
- risk factors (1)
- risk stratification (1)
- robust test statistic (1)
- satellite telemetry (1)
- schizophrenia (1)
- secondary data analysis (1)
- selenolates (1)
- self-assembled monolayers (1)
- sepsis (1)
- simplified production (1)
- single subject classification (1)
- smart home (1)
- smart living (1)
- spectra (1)
- stage-based models (1)
- standardization (1)
- structural proteins (1)
- strumpellin (1)
- stuttering (1)
- subgrouping (1)
- surface chemistry (1)
- surface-mounted metal–organic frameworks (SURMOFs) (1)
- surgical margin (1)
- survivin (1)
- sustainable travel (1)
- targeted biopsy (1)
- temozolomide (1)
- temporal classification (1)
- thiolates (1)
- transrectal prostate biopsy (1)
- trauma (1)
- travel behavior change (1)
- treatment centres (1)
- treatment resistance (1)
- triptycene (1)
- tropical forests (1)
- tumor microenvironment (1)
- tumor weight (1)
- tyrosine kinase inhibitor (TKI) (1)
- upgrading (1)
- uveal melanoma (1)
- ventral striatum (1)
- volatile organic compounds (1)
- waiting time (1)
- web of things (1)
- Öffentlichkeit (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (1060)
- Frankfurt Institute for Advanced Studies (FIAS) (955)
- Informatik (923)
- Medizin (123)
- Geowissenschaften (42)
- Biowissenschaften (13)
- Biochemie, Chemie und Pharmazie (11)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (8)
- Geographie (7)
- Geowissenschaften / Geographie (7)
Background: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape.
Material and methods: VX-2 tumor was used for the induction of experimental bone metastases in the femur of six New Zealand white rabbits. X-ray imaging as well as CT and MRI scans before and after treatment was carried out. After detecting bone tumor, radiofrequency ablation was performed. The ablation instrument contained a 10 g bipolar, articulated extendable electrode and a proprietary generator with an impedance controlled algorithm. All bones and the soft tissue were examined histologically.
Results: All animals developed local bone tumor. Mean duration until first osteolytic lesions on CT-scans was 48±14 days. The mean lesion area was 26 mm(2). No systemic tumor spread was seen. 6 radiofrequency procedures were carried out with a mean application time of 6 min±2:30 and an average temperature in the region of effect of 55 °C±4. MRI imaging demonstrated an ablation zone of 23±6 mm around the electrode. Histopathology showed an extensive heat necrosis with no remaining tumor cells in the ablation area.
Conclusion: Radiofrequency ablation is a quickly developing treatment option on the field of minimal invasive bone tumor therapy. The electrode enables an ablation adapted to size and shape of the metastases. Further clinical studies are necessary to test and enhance this radiofrequency system.
Using the notion of a root datum of a reductive group G we propose a tropical analogue of a principal G-bundle on a metric graph. We focus on the case G=GLn, i.e. the case of vector bundles. Here we give a characterization of vector bundles in terms of multidivisors and use this description to prove analogues of the Weil--Riemann--Roch theorem and the Narasimhan--Seshadri correspondence. We proceed by studying the process of tropicalization. In particular, we show that the non-Archimedean skeleton of the moduli space of semistable vector bundles on a Tate curve is isomorphic to a certain component of the moduli space of semistable tropical vector bundles on its dual metric graph.
Der Vorstand der Deutschen Gesellschaft für Epileptologie und die Kommission „Epilepsie und Synkopen“ der Deutschen Gesellschaft für Neurologie haben die aktuelle Datenlage zur Impfung zur Vorbeugung der Corona-Virus-Krankheit 2019 (COVID-19) sowie zur Impfpriorisierung bei Menschen mit Epilepsie gesichtet, diese zusammengefasst und geben die unten genannten Empfehlungen ab.
Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyosarcoma, and melanoma) were continuously exposed to increasing concentrations of the murine double minute 2 inhibitor nutlin-3, resulting in the emergence of nutlin-3-resistant, p53-mutated sublines displaying a multi-drug resistance phenotype. Only 2 out of 28 sublines adapted to various cytotoxic drugs harboured p53 mutations. Nutlin-3-adapted UKF-NB-3 cells (UKF-NB-3rNutlin10 μM, harbouring a G245C mutation) were also radiation resistant. Analysis of UKF-NB-3 and UKF-NB-3rNutlin10 μM cells by RNA interference experiments and lentiviral transduction of wild-type p53 into p53-mutated UKF-NB-3rNutlin10 μM cells revealed that the loss of p53 function contributes to the multi-drug resistance of UKF-NB-3rNutlin10 μM cells. Bioinformatics PANTHER pathway analysis based on microarray measurements of mRNA abundance indicated a substantial overlap in the signalling pathways differentially regulated between UKF-NB-3rNutlin10 μM and UKF-NB-3 and between UKF-NB-3 and its cisplatin-, doxorubicin-, or vincristine-resistant sublines. Repeated nutlin-3 adaptation of neuroblastoma cells resulted in sublines harbouring various p53 mutations with high frequency. A p53 wild-type single cell-derived UKF-NB-3 clone was adapted to nutlin-3 in independent experiments. Eight out of ten resulting sublines were p53-mutated harbouring six different p53 mutations. This indicates that nutlin-3 induces de novo p53 mutations not initially present in the original cell population. Therefore, nutlin-3-treated cancer patients should be carefully monitored for the emergence of p53-mutated, multi-drug-resistant cells.
Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. In addition, repeated adaptation of the RITA-adapted sub-line UKF-NB-3rRITA10 μM to nutlin-3 resulted in p53 mutations. The RITA-adapted UKF-NB-3 sub-lines displayed no or less pronounced resistance to vincristine, cisplatin, and irradiation than nutlin-3-adapted UKF-NB-3 sub-lines. Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3. Transcriptomic analyses indicated the RITA-adapted sub-lines to be more similar at the gene expression level to the parental UKF-NB-3 cells than nutlin-3-adapted UKF-NB-3 sub-lines, which correlates with the observed chemotherapy and irradiation sensitivity phenotypes. In conclusion, RITA-adapted cells retain functional p53, remain sensitive to nutlin-3, and display a less pronounced resistance phenotype than nutlin-3-adapted cells.
Investigators in the cognitive neurosciences have turned to Big Data to address persistent replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. While there is tremendous potential to advance science through open data sharing, these efforts unveil a host of new questions about how to integrate data arising from distinct sources and instruments. We focus on the most frequently assessed area of cognition - memory testing - and demonstrate a process for reliable data harmonization across three common measures. We aggregated raw data from 53 studies from around the world which measured at least one of three distinct verbal learning tasks, totaling N = 10,505 healthy and brain-injured individuals. A mega analysis was conducted using empirical bayes harmonization to isolate and remove site effects, followed by linear models which adjusted for common covariates. After corrections, a continuous item response theory (IRT) model estimated each individual subject’s latent verbal learning ability while accounting for item difficulties. Harmonization significantly reduced inter-site variance by 37% while preserving covariate effects. The effects of age, sex, and education on scores were found to be highly consistent across memory tests. IRT methods for equating scores across AVLTs agreed with held-out data of dually-administered tests, and these tools are made available for free online. This work demonstrates that large-scale data sharing and harmonization initiatives can offer opportunities to address reproducibility and integration challenges across the behavioral sciences.
Background: The approval of everolimus (EVE) for the treatment of angiomyolipoma (2013), subependymal giant cell astrocytoma (2013) and drug-refractory epilepsy (2017) in patients with tuberous sclerosis complex (TSC) represents the first disease-modifying treatment option available for this rare and complex genetic disorder. Objective: The objective of this study was to analyse the use, efficacy, tolerability and treatment retention of EVE in patients with TSC in Germany from the patient’s perspective. Methods: A structured cross-age survey was conducted at 26 specialised TSC centres in Germany and by the German TSC patient advocacy group between February and July 2019, enrolling children, adolescents and adult patients with TSC. Results: Of 365 participants, 36.7% (n = 134) reported the current or past intake of EVE, including 31.5% (n = 115) who were taking EVE at study entry. The mean EVE dosage was 6.1 ± 2.9 mg/m2 (median: 5.6 mg/m2, range 2.0–15.1 mg/m2) in children and adolescents and 4 ± 2.1 mg/m2 (median: 3.7 mg/m2, range 0.8–10.1 mg/m2) in adult patients. An early diagnosis of TSC, the presence of angiomyolipoma, drug-refractory epilepsy, neuropsychiatric manifestations, subependymal giant cell astrocytoma, cardiac rhabdomyoma and overall multi-organ involvement were associated with the use of EVE as a disease-modifying treatment. The reported efficacy was 64.0% for angiomyolipoma (75% in adult patients), 66.2% for drug-refractory epilepsy, and 54.4% for subependymal giant cell astrocytoma. The overall retention rate for EVE was 85.8%. The retention rates after 12 months of EVE therapy were higher among adults (93.7%) than among children and adolescents (88.7%; 90.5% vs 77.4% after 24 months; 87.3% vs 77.4% after 36 months). Tolerability was acceptable, with 70.9% of patients overall reporting adverse events, including stomatitis (47.0%), acne-like rash (7.7%), increased susceptibility to common infections and lymphoedema (each 6.0%), which were the most frequently reported symptoms. With a total score of 41.7 compared with 36.8 among patients not taking EVE, patients currently being treated with EVE showed an increased Liverpool Adverse Event Profile. Noticeable deviations in the sub-items ‘tiredness’, ‘skin problems’ and ‘mouth/gum problems’, which are likely related to EVE-typical adverse effects, were more frequently reported among patients taking EVE. Conclusions: From the patients’ perspective, EVE is an effective and relatively well-tolerated disease-modifying treatment option for children, adolescents and adults with TSC, associated with a high long-term retention rate that can be individually considered for each patient. Everolimus therapy should ideally be supervised by a centre experienced in the use of mechanistic target of rapamycin inhibitors, and adverse effects should be monitored on a regular basis.
The Board of Directors of the German Society of Epileptology and the committee on epilepsy and syncope of the German Society of Neurology have reviewed the current data on vaccination to prevent coronavirus disease 2019 (COVID-19) and vaccination prioritization in people with epilepsy and provide a summary and recommendations.
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
Background: Intestinal perforation or leakage increases morbidity and mortality of surgical and endoscopic interventions. We identified criteria for use of full-covered, extractable self-expanding metal stents (cSEMS) vs. "Over the scope"-clips (OTSC) for leak closure.
Methods: Patients who underwent endoscopic treatment for postoperative leakage, endoscopic perforation, or spontaneous rupture of the upper gastrointestinal tract between 2006 and 2013 were identified at four tertiary endoscopic centers. Technical success, outcome (e.g. duration of hospitalization, in-hospital mortality), and complications were assessed and analyzed with respect to etiology, size and location of leakage.
Results: Of 106 patients (male: 75 (71%), female: 31 (29%); age (mean ± SD): 62.5 ± 1.3 years, 72 (69%) were treated by cSEMS and 34 (31%) by OTSC. For cSEMS vs. OTSC, mean treatment duration was 41.1 vs. 25 days, p<0.001, leakage size 10 (1-50) vs. 5 (1-30) mm (median (range)), and complications were observed in 68% vs. 8.8%, p<0.001, respectively. Clinical success for primary interventional treatment was observed in 29/72 (40%) vs. 24/34 (70%, p = 0.006), and clinical success at the end of follow-up was 46/72 (64%) vs. 29/34 (85%) for patients treated by cSEMS vs. OTSC; p = 0.04.
Conclusion: OTSC is preferred in small-sized lesions and in perforation caused by endoscopic interventions, cSEMS in patients with concomitant local infection or abscess. cSEMS is associated with a higher frequency of complications. Therefore, OTSC might be preferred if technically feasible. Indication criteria for cSEMS vs. OTSC vary and might impede design of randomized studies.
Children’s and adolescents’ lives drastically changed during COVID lockdowns worldwide. To compare accident- and injury-related admissions to pediatric intensive care units (PICU) during the first German COVID lockdown with previous years, we conducted a retrospective multicenter study among 37 PICUs (21.5% of German PICU capacities). A total of 1444 admissions after accidents or injuries during the first lockdown period and matched periods of 2017–2019 were reported and standardized morbidity ratios (SMR) were calculated. Total PICU admissions due to accidents/injuries declined from an average of 366 to 346 (SMR 0.95 (CI 0.85–1.05)). Admissions with trauma increased from 196 to 212 (1.07 (0.93–1.23). Traffic accidents and school/kindergarten accidents decreased (0.77 (0.57–1.02 and 0.26 (0.05–0.75)), whereas household and leisure accidents increased (1.33 (1.06–1.66) and 1.34 (1.06–1.67)). Less neurosurgeries and more visceral surgeries were performed (0.69 (0.38–1.16) and 2.09 (1.19–3.39)). Non-accidental non-suicidal injuries declined (0.73 (0.42–1.17)). Suicide attempts increased in adolescent boys (1.38 (0.51–3.02)), but decreased in adolescent girls (0.56 (0.32–0.79)). In summary, changed trauma mechanisms entailed different surgeries compared to previous years. We found no evidence for an increase in child abuse cases requiring intensive care. The increase in suicide attempts among boys demands investigation.
Background: To study neoadjuvant chemoradiotherapy (nCRT) and potential predictive factors for response in locally advanced oral cavity cancer (LA-OCC).
Methods: The INVERT trial is an ongoing single-center, prospective phase 2, proof-of-principle trial. Operable patients with stage III-IVA squamous cell carcinomas of the oral cavity were eligible and received nCRT consisting of 60 Gy with concomitant cisplatin and 5-fluorouracil. Surgery was scheduled 6-8 weeks after completion of nCRT. Explorative, multiplex immunohistochemistry (IHC) was performed on pretreatment tumor specimen, and diffusion-weighted magnetic resonance imaging (DW-MRI) was conducted prior to, during nCRT (day 15), and before surgery to identify potential predictive biomarkers and imaging features. Primary endpoint was the pathological complete response (pCR) rate.
Results: Seventeen patients with stage IVA OCC were included in this interim analysis. All patients completed nCRT. One patient died from pneumonia 10 weeks after nCRT before surgery. Complete tumor resection (R0) was achieved in 16/17 patients, of whom 7 (41%, 95% CI: 18-67%) showed pCR. According to the Clavien-Dindo classification, grade 3a and 3b complications were found in 4 (25%) and 5 (31%) patients, respectively; grade 4-5 complications did not occur. Increased changes in the apparent diffusion coefficient signal intensities between MRI at day 15 of nCRT and before surgery were associated with better response (p=0.022). Higher abundances of programmed cell death protein 1 (PD1) positive cytotoxic T-cells (p=0.012), PD1+ macrophages (p=0.046), and cancer-associated fibroblasts (CAFs, p=0.036) were associated with incomplete response to nCRT.
Conclusion: nCRT for LA-OCC followed by radical surgery is feasible and shows high response rates. Larger patient cohorts from randomized trials are needed to further investigate nCRT and predictive biomarkers such as changes in DW-MRI signal intensities, tumor infiltrating immune cells, and CAFs.
Viele Städte in Deutschland stehen aktuell vor komplexen ökonomischen, ökologischen und sozialen Herausforderungen, die mit klassischen ressortbezogenen Planungskonzepten nicht zu bewältigen sind. Integrierte Stadtentwicklungskonzepte erleben deshalb vielerorts eine Renaissance in der städtischen Planungspraxis. Die in diesem Zusammenhang diskutierten Planungsleitbilder geben jedoch nur selten direkt umsetzbare Handlungskonzepte vor. In diesem Beitrag werden deshalb am Beispiel der Stadt Leipzig konkrete Handlungsoptionen für eine an nachhaltiger Mobilität orientierte Stadtentwicklung vorgestellt. Aufbauend auf bisherigen Erkenntnissen zu integrierten Stadtentwicklungskonzepten werden zunächst infrastrukturbezogene Konzepte zur Förderung des Wohnens im Innenbereich, zur Stärkung städtischer Zentren sowie zur Förderung der Nahmobilität dargestellt. Darüber hinaus werden auch politische, organisatorische und kommunikative Handlungsoptionen aufgezeigt. Diese umfassen Maßnahmen zur Verbesserung der übergeordneten Rahmenbedingungen, Konzepte zur Stärkung der inter- und intrakommunalen Kooperation sowie integrierte städtische Mobilitätskonzepte. Das Beispiel Leipzig macht dabei deutlich, dass infrastrukturelle Ansätze für eine an nachhaltiger Mobilitätsgestaltung orientierte Stadtentwicklung nicht ausreichend sind. Vielmehr ist eine bessere Abstimmung der Stadt- und Verkehrsplanung auf die Bedürfnisse der Bevölkerung erforderlich; dazu gehört auch die Integration von Mobilitätsmanagementmaßnahmen in städtische Verkehrskonzepte. Für eine wirksame Umsetzung integrierter Stadtentwicklungskonzepte erscheinen außerdem eine an Nachhaltigkeitszielen orientierte Gestaltung der rechtlichen und politischen Rahmenbedingungen sowie eine stärkere Berücksichtigung regionaler Verknüpfungen in städtischen Planungen notwendig.