Refine
Year of publication
Document Type
- Preprint (269)
- Article (179)
- Working Paper (3)
Language
- English (451)
Has Fulltext
- yes (451) (remove)
Is part of the Bibliography
- no (451) (remove)
Keywords
- LHC (8)
- Heavy Ion Experiments (6)
- ALICE experiment (4)
- Hadron-Hadron Scattering (3)
- Hadron-Hadron scattering (experiments) (3)
- Heavy Ions (3)
- Heavy-ion collision (3)
- pp collisions (3)
- ALICE (2)
- Beauty production (2)
- Charm physics (2)
- Pb–Pb collisions (2)
- Single electrons (2)
- ALICE detector (1)
- Anti-nuclei (1)
- Brain tumor (1)
- Centrality Class (1)
- Centrality Selection (1)
- Comparison with QCD (1)
- Cryoelectron microscopy (1)
- EWSR1 (1)
- Electron-pion identification (1)
- Elliptic flow (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- Gene fusion (1)
- Gewerkschaftlicher Organisationsgrad / Gewerkschaft / Mitgliedschaft / Berufsstruktur / Sektorale Beschäftigungsstruktur / Schätzung / Deutschland (1)
- HBT (1)
- Hadron production (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- IT innovations (1)
- Inclusive spectra (1)
- Intensity interferometry (1)
- Invariant Mass Distribution (1)
- Ionisation energy loss (1)
- Jets (1)
- MN1 (1)
- Mass spectrometry (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Monte Carlo (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Neural network (1)
- Neuroepithelial (1)
- Neurooncology (1)
- Nuclear modification factor (1)
- PATZ1 (1)
- Particle correlations and fluctuations (1)
- Pb–Pb (1)
- Pediatric (1)
- Production Cross Section (1)
- Proton–proton (1)
- QCD (1)
- Quark gluon plasma (1)
- Rapidity Range (1)
- Relativistic heavy ion physics (1)
- Resolution Parameter (1)
- Ribosome (1)
- Single muons (1)
- Systematic Uncertainty (1)
- TR (1)
- Time Projection Chamber (1)
- Tracking (1)
- Transition radiation detector (1)
- Trigger (1)
- Xenon-based gas mixture (1)
- cellular self-organization (1)
- computational modeling (1)
- correlated random effects probit model (1)
- dE/dx (1)
- digital twin (1)
- financial services (1)
- gross and net union density (1)
- heavy ion experiments (1)
- quark gluon plasma (1)
- spectra (1)
- structural biology (1)
- union membership (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (431)
- Frankfurt Institute for Advanced Studies (FIAS) (396)
- Informatik (379)
- MPI für Biophysik (8)
- Biochemie und Chemie (5)
- Biowissenschaften (5)
- E-Finance Lab e.V. (3)
- Wirtschaftswissenschaften (3)
- Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) (2)
- Center for Financial Studies (CFS) (2)
Nuclear pore complexes (NPCs) constitute giant channels within the nuclear envelope that mediate nucleocytoplasmic exchange. NPC diameter is thought to be regulated by nuclear envelope tension, but how such diameter changes are physiologically linked to cell differentiation, where mechanical properties of nuclei are remodeled and nuclear mechanosensing occurs, remains unstudied. Here we used cryo-electron tomography to show that NPCs dilate during differentiation of mouse embryonic stem cells into neural progenitors. In Nup133-deficient cells, which are known to display impaired neural differentiation, NPCs however fail to dilate. By analyzing the architectures of individual NPCs with template matching, we revealed that the Nup133-deficient NPCs are structurally heterogeneous and frequently disintegrate, resulting in the formation of large nuclear envelope openings. We propose that the elasticity of the NPC scaffold mechanically safeguards the nuclear envelope. Our studies provide a molecular explanation for how genetic perturbation of scaffolding components of macromolecular complexes causes tissue-specific phenotypes.