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Sedimentologie und Verwitterungsbeständigkeit des Wellenkalks
(Unterer Muschelkalk) von Osnabrück
(1993)
Die Sedimentologie und Verwitterungsbeständigkeit des Osnabrücker Weilenkalks (Unterer Muschelkalk) werden an Mauersteinen aus zwei Gebäuden in Osnabrück und an Proben aus dem Steinbruch im Botanischen Garten Osnabrück untersucht. Es lassen sich 6 Mikrofaziestypen (A-F) unterscheiden, die ausführlich beschrieben werden. Ihre Analyse erlaubt detaillierte Aussagen zum Sedimentationsraum und zur Entstehung. Darauf aufbauend werden die in der Schichtenfolge beobachtbaren Sedimentationszyklen auf Meeresspiegeländerungen zurückgeführt. Es lassen sich deutliche Unterschiede in der Verwitterungsbeständigkeit der verschiedenen Mikrofaziestypen erkennen. Am verwitterungsbeständigsten sind die Mikrofaziestypen A und B, durch Sturmfluten entstandene Lagen im unteren und oberen Teil des Oolithbank-Members der Wellenkalk-Formation. Die Mikrofaziestypen A und B sind so verwitterungsbeständig., da sie nicht feingeschichtet sind und freiwillige Wasseraufnahme, Schurecht-Ratio (= freiwillige Wasseraufnahme geteilt durch effektive Porosität) sowie der Gehalt an salzsäureunlöslichem Rückstand relativ gering sind.
Die Art und Weise, wie das Verhältnis von Staat und Unternehmen in Indien seit den 1980er Jahren restrukturiert wurde, liefert wichtige Lektionen für das Verständnis des modernen Kapitalismus in großen Schwellenländern, auch im Kontrast zum traditionellen Modell des ostasiatischen Entwicklungsstaats. Ausgehend vom historischen Entstehungskontext entwickeln wir eine Charakterisierung des Staatskapitalismus in den indischen Ballungszentren als „staatlich durchdrungene Marktökonomie“, bevor wir die Schattenseiten dieses Modells, insbesondere gravierende Ungleichheit, skizzieren, die – trotz aller wirtschaftlichen Dynamik des Kapitalismus in großen Schwellenländern wie Indien – notwendig mit diesem Wirtschaftsmodell verbunden sind.
The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Most SARS-CoV-2 infections are mild or even asymptomatic. However, a small fraction of infected individuals develops severe, life-threatening disease, which is caused by an uncontrolled immune response resulting in hyperinflammation. However, the factors predisposing individuals to severe disease remain poorly understood. Here, we show that levels of CD47, which is known to mediate immune escape in cancer and virus-infected cells, are elevated in SARS-CoV-2-infected Caco-2 cells, Calu-3 cells, and air−liquid interface cultures of primary human bronchial epithelial cells. Moreover, SARS-CoV-2 infection increases SIRPalpha levels, the binding partner of CD47, on primary human monocytes. Systematic literature searches further indicated that known risk factors such as older age and diabetes are associated with increased CD47 levels. High CD47 levels contribute to vascular disease, vasoconstriction, and hypertension, conditions that may predispose SARS-CoV-2-infected individuals to COVID-19-related complications such as pulmonary hypertension, lung fibrosis, myocardial injury, stroke, and acute kidney injury. Hence, age-related and virus-induced CD47 expression is a candidate mechanism potentially contributing to severe COVID-19, as well as a therapeutic target, which may be addressed by antibodies and small molecules. Further research will be needed to investigate the potential involvement of CD47 and SIRPalpha in COVID-19 pathology. Our data should encourage other research groups to consider the potential relevance of the CD47/ SIRPalpha axis in their COVID-19 research.
In resource-limited or point-of-care settings, rapid diagnostic tests (RDTs), that aim to simultaneously detect HIV antibodies and p24 capsid (p24CA) antigen with high sensitivity, can pose important alternatives to screen for early infections. We evaluated the performance of the antibody and antigen components of the old and novel version of the Determine™ HIV-1/2 Ag/Ab Combo RDTs in parallel to quantifications in a fourth-generation antigen/antibody immunoassay (4G-EIA), p24CA antigen immunoassay (p24CA-EIA), immunoblots, and nucleic acid quantification. We included plasma samples of acute, treatment-naïve HIV-1 infections (Fiebig stages I–VI, subtypes A1, B, C, F, CRF02_AG, CRF02_AE, URF) or chronic HIV-1 and HIV-2 infections. The tests’ antigen component was evaluated also for a panel of subtype B HIV-1 transmitted/founder (T/F) viruses, HIV-2 strains and HIV-2 primary isolates. Furthermore, we assessed the analytical sensitivity of the RDTs to detect p24CA using a highly purified HIV-1NL4-3 p24CA standard. We found that 77% of plasma samples from acutely infected, immunoblot-negative HIV-1 patients in Fiebig stages II–III were identified by the new RDT, while only 25% scored positive in the old RDT. Both RDTs reacted to all samples from chronically HIV-1-infected and acutely HIV-1-infected patients with positive immunoblots. All specimens from chronically infected HIV-2 patients scored positive in the new RDT. Of note, the sensitivity of the RDTs to detect recombinant p24CA from a subtype B virus ranged between 50 and 200 pg/mL, mirrored also by the detection of HIV-1 T/F viruses only at antigen concentrations tenfold higher than suggested by the manufacturer. The RTD failed to recognize any of the HIV-2 viruses tested. Our results indicate that the new version of the Determine™ HIV-1/2 Ag/Ab Combo displays an increased sensitivity to detect HIV-1 p24CA-positive, immunoblot-negative plasma samples compared to the precursor version. The sensitivity of 4G-EIA and p24CA-EIA to detect the major structural HIV antigen, and thus to diagnose acute infections prior to seroconversion, is still superior.