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The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Ecological networks are more sensitive to plant than to animal extinction under climate change
(2016)
Impacts of climate change on individual species are increasingly well documented, but we lack understanding of how these effects propagate through ecological communities. Here we combine species distribution models with ecological network analyses to test potential impacts of climate change on >700 plant and animal species in pollination and seed-dispersal networks from central Europe. We discover that animal species that interact with a low diversity of plant species have narrow climatic niches and are most vulnerable to climate change. In contrast, biotic specialization of plants is not related to climatic niche breadth and vulnerability. A simulation model incorporating different scenarios of species coextinction and capacities for partner switches shows that projected plant extinctions under climate change are more likely to trigger animal coextinctions than vice versa. This result demonstrates that impacts of climate change on biodiversity can be amplified via extinction cascades from plants to animals in ecological networks.
Purpose: Molecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in brain tumor patients. We aimed to evaluate the decision-making process of molecular targeted therapies and analyze data on tolerability as well as signals for efficacy.
Methods: Via retrospective analysis, we identified primary brain tumor patients who were treated off-label with a targeted therapy at the University Hospital Frankfurt, Goethe University. We analyzed which types of molecular alterations were utilized to guide molecular off-label therapies and the diagnostic procedures for their assessment during the period from 2008 to 2021. Data on tolerability and outcomes were collected.
Results: 413 off-label therapies were identified with an increasing annual number for the interval after 2016. 37 interventions (9%) were targeted therapies based on molecular markers. Glioma and meningioma were the most frequent entities treated with molecular matched targeted therapies. Rare entities comprised e.g. medulloblastoma and papillary craniopharyngeoma. Molecular targeted approaches included checkpoint inhibitors, inhibitors of mTOR, FGFR, ALK, MET, ROS1, PIK3CA, CDK4/6, BRAF/MEK and PARP. Responses in the first follow-up MRI were partial response (13.5%), stable disease (29.7%) and progressive disease (46.0%). There were no new safety signals. Adverse events with fatal outcome (CTCAE grade 5) were not observed. Only, two patients discontinued treatment due to side effects. Median progression-free and overall survival were 9.1/18 months in patients with at least stable disease, and 1.8/3.6 months in those with progressive disease at the first follow-up MRI.
Conclusion: A broad range of actionable alterations was targeted with available molecular therapeutics.
However, efficacy was largely observed in entities with paradigmatic oncogenic drivers, in particular with BRAF mutations. Further research on biomarker-informed molecular matched therapies is urgently necessary.
Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.
Im folgenden sollen an repräsentativen literarischen Werken Hauptaspekte der dichterischen Bedeutung des Teppichs aufgezeigt werden. Da Teppiche bei uns noch im 18. Jahrhundert mehr als Decken und Vorhänge denn als Bodenbelag verwendet wurden, ist die Terminologie auf diesem Gebiet fließend. Noch mehr gilt dies von der Antike." Die Auswahl der Texte ist nicht von der Verwendung oder der Herstellungstechnik, sondern von literarischen Gesichtspunkten bestimmt. Kultur- und Religionsgeschichte - so unentbehrlich sie für unseren Zusammenhang sind - bleiben Hintergrund, nicht Selbstzweck. Neben die Säkularisation sakraler Elemente tritt ebenbürtig die Verklärung des Realen. Die gewählte Gliederung nach Funktions- und Deutungstypen - Ehrenteppich, Bildteppich, Rasenteppich, Teppich als Trennendes, Lebensteppich, Teppich und Transfiguration des Raumes - läßt klarer als eine rein chronologische Gruppierung Grundmöglichkeiten poetischer Gestaltung und den individuellen Beitrag der Dichter hervortreten. Es versteht sich von selbst, daß bedeutende Texte unter mehreren Gesichtspunkten Beachtung heischen; Querverbindungen werden betont, Wiederholungen jedoch möglichst vermieden. Das Ziel unserer Fragestellung liegt einerseits in der Einzelinterpretation, zumal für die meisten unserer Texte die motivgeschichtliche Perspektive neu ist, andererseits in allgemeinen formalen und inhaltlichen Folgerungen.
We give a report of the fourth annual symposium of the Dry Grassland Working Group, which was organized in conjunction with the second workshop ‘Floristics and geobotany - Contributions to applied questions’, from 6 to 8 Sept. 2007 in Freising-Weihenstephan. The symposium was entitled ‘Restoration and spontaneous establishment of dry and semi-dry grasslands at traditional and urban-industrial sites’. Additionally, the aims of the Dry Grassland Working Group are shortly outlined and the next symposia of both groups are announced.
Joint Venture : International Max Planck Research School for comparative european legal history
(2002)
Gegenwärtigen Fusionspraktiken folgend, haben auch Rechtshistoriker sich verbündet, um international Synergien zu erzeugen. Das Max-Planck-Institut für europäische Rechtsgeschichte und das Institut für Rechtsgeschichte an der Johann Wolfgang Goethe-Universität haben – mit dem Segen und dem Geld ihrer "Mütter" – ein gemeinsames Forschungskolleg gegründet. ...
Objectives: An increasing number of treatment-determining biomarkers has been identified in non-small cell lung cancer (NSCLC) and molecular testing is recommended to enable optimal individualized treatment. However, data on implementation of these recommendations in the “real-world” setting are scarce. This study presents comprehensive details on the frequency, methodology and results of biomarker testing of advanced NSCLC in Germany.
Patients and methods: This analysis included 3,717 patients with advanced NSCLC (2,921 non-squamous; 796 squamous), recruited into the CRISP registry at start of systemic therapy by 150 German sites between December 2015 and June 2019. Evaluated were the molecular biomarkers EGFR, ALK, ROS1, BRAF, KRAS, MET, TP53, RET, HER2, as well as expression of PD-L1.
Results: In total, 90.5 % of the patients were tested for biomarkers. Testing rates were 92.2 % (non-squamous), 70.7 % (squamous) and increased from 83.2 % in 2015/16 to 94.2% in 2019. Overall testing rates for EGFR, ALK, ROS1, and BRAF were 72.5 %, 74.5 %, 66.1 %, and 53.0 %, respectively (non-squamous). Testing rates for PD-L1 expression were 64.5 % (non-squamous), and 58.5 % (squamous). The most common testing methods were immunohistochemistry (68.5 % non-squamous, 58.3 % squamous), and next-generation sequencing (38.7 % non-squamous, 14.4 % squamous). Reasons for not testing were insufficient tumor material or lack of guideline recommendations (squamous). No alteration was found in 37.8 % (non-squamous), and 57.9 % (squamous), respectively. Most common alterations in non-squamous tumors (all patients/all patients tested for the respective biomarker): KRAS (17.3 %/39.2 %), TP53 (14.1 %/51.4 %), and EGFR (11.0 %/15.1 %); in squamous tumors: TP53 (7.0 %/69.1 %), MET (1.5 %/11.1 %), and EGFR (1.1 %/4.4 %). Median PFS (non-squamous) was 8.7 months (95 % CI 7.4–10.4) with druggable EGFR mutation, and 8.0 months (95 % CI 3.9–9.2) with druggable ALK alterations.
Conclusion: Testing rates in Germany are high nationwide and acceptable in international comparison, but still leave out a significant portion of patients, who could potentially benefit. Thus, specific measures are needed to increase implementation.
A survey on worries of pregnant women - testing the German version of the Cambridge Worry Scale
(2009)
Background: Pregnancy is a transition period in a woman's life characterized by increased worries and anxiety. The Cambridge Worry Scale (CWS) was developed to assess the content and extent of maternal worries in pregnancy. It has been increasingly used in studies over recent years. However, a German version has not yet been developed and validated. The aim of this study was (1) to assess the extent and content of worries in pregnancy on a sample of women in Germany using a translated and adapted version of the Cambridge Worry Scale, and (2) to evaluate the psychometric properties of the German version. Methods: We conducted a cross-sectional study and enrolled 344 pregnant women in the federal state of Baden-Wurttemberg, Germany. Women filled out structured questionnaires that contained the CWS, the Spielberger-State-Trait-Anxiety Inventory (STAI), as well as questions on their obstetric history. Antenatal records were also analyzed. Results: The CWS was well understood and easy to fill in. The major worries referred to the process of giving birth (CWS mean value 2.26) and the possibility that something might be wrong with the baby (1.99), followed by coping with the new baby (1.57), going to hospital (1.29) and the possibility of going into labour too early (1.28). The internal consistency of the scale (0.80) was satisfactory, and we found a four-factor structure, similar to previous studies. Tests of convergent validity showed that the German CWS represents a different construct compared with state and trait anxiety but has the desired overlap. Conclusions: The German CWS has satisfactory psychometric properties. It represents a valuable tool for use in scientific studies and is likely to be useful also to clinicians.
Ausgangspunkt ist die Beobachtung, dass sich empirisch eine inklusive Schule oftmals als eine differenzierte und differenzierende Schule darstellt. Dies bezieht sich etwa auf die Ausdifferenzierung der ‚heterogenen Lehrgruppe‘. Im zeitgemäßen inklusiven Unterricht sind allgemein- und sonderpädagogische Lehrkräfte ebenso wie Schulbegleitungen anwesend. Auch Sozialpädagog*innen und Therapeut*innen gehören vermehrt zum Schulalltag.
Vorliegende Studien dokumentieren, dass die Gestaltung inklusiver Schulen bzw. von inklusivem Unterricht von nicht intendierten Effekten und Widerständigkeiten der Akteur*innen begleitet ist. Im Beitrag werden – basierend auf der ProFiS-Studie – zwei Herausforderungen von inklusiven Schulen in den Mittelpunkt gerückt. Zum einen wird auf das Spannungsfeld von Professionalisierung und Deprofessionalisierung eingegangen. Zum anderen stellt das Verhältnis von Kategorisierung und Dekategorisierung eine Herausforderung dar. Beide Relationen sind als Spannungsverhältnisse untereinander und zueinander zu denken, die sich nicht ‚einfach‘ in eine Richtung auflösen lassen, sondern die in ihrer Widersprüchlichkeit gerade konstitutiv für die Praxis ‚inklusiver Schulen‘ wirken. Zentrale Frage des Beitrags ist, wie dieses komplexe Spannungsverhältnis der wechselseitigen Bezogenheit de/kategorisierender und de/professionalisierender Prozesse in professionellen Aktivitäten hervorgebracht wird.
Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.
Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P<0.001); there was no difference between serum miR-21 in patients with CHC and CHC-associated HCC. Serum miR-21 levels correlated with histological activity index (HAI) in the liver (r = −0.494, P = 0.00002), alanine aminotransferase (ALT) (r = −0.309, P = 0.007), aspartate aminotransferase (r = −0.495, P = 0.000007), bilirubin (r = −0.362, P = 0.002), international normalized ratio (r = −0.338, P = 0.034) and γ-glutamyltransferase (r = −0.244, P = 0.034). Multivariate analysis revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21 discriminated between minimal and mild-severe necroinflammation (AUC = 0.758) with a sensitivity of 53.3% and a specificity of 95.2%.
Conclusions/Significance: The serum miR-21 level is a marker for necroinflammatory activity, but does not differ between patients with HCV and HCV-induced HCC.
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a bone volume phenotype. Methodology/Principal Findings: We found that Per2Brdm1 mutant mice as well as mice lacking Cry2-/- displayed significantly increased bone volume at 12 weeks of age, when bone turnover is high. Per2Brdm1 mutant mice showed alterations in parameters specific for osteoblasts whereas mice lacking Cry2-/- displayed changes in osteoclast specific parameters. Interestingly, inactivation of both Per2 and Cry2 genes leads to normal bone volume as observed in wild type animals. Importantly, osteoclast parameters affected due to the lack of Cry2, remained at the level seen in the Cry2-/- mutants despite the simultaneous inactivation of Per2. Conclusions/Significance: This indicates that Cry2 and Per2 affect distinct pathways in the regulation of bone volume with Cry2 influencing mostly the osteoclastic cellular component of bone and Per2 acting on osteoblast parameters.
Species’ functional traits set the blueprint for pair-wise interactions in ecological networks. Yet, it is unknown to what extent the functional diversity of plant and animal communities controls network assembly along environmental gradients in real-world ecosystems. Here we address this question with a unique dataset of mutualistic bird–fruit, bird–flower and insect–flower interaction networks and associated functional traits of 200 plant and 282 animal species sampled along broad climate and land-use gradients on Mt. Kilimanjaro. We show that plant functional diversity is mainly limited by precipitation, while animal functional diversity is primarily limited by temperature. Furthermore, shifts in plant and animal functional diversity along the elevational gradient control the niche breadth and partitioning of the respective other trophic level. These findings reveal that climatic constraints on the functional diversity of either plants or animals determine the relative importance of bottom-up and top-down control in plant–animal interaction networks.
Background: Risk stratification, detection of minimal residual disease (MRD), and implementation of novel therapeutic agents have improved outcome in acute lymphoblastic leukemia (ALL), but survival of adult patients with T-cell acute lymphoblastic leukemia (T-ALL) remains unsatisfactory. Thus, novel molecular insights and therapeutic approaches are urgently needed.
Methods: We studied the impact of B-cell CLL/lymphoma 11b (BCL11b), a key regulator in normal T-cell development, in T-ALL patients enrolled into the German Multicenter Acute Lymphoblastic Leukemia Study Group trials (GMALL; n = 169). The mutational status (exon 4) of BCL11b was analyzed by Sanger sequencing and mRNA expression levels were determined by quantitative real-time PCR. In addition gene expression profiles generated on the Human Genome U133 Plus 2.0 Array (affymetrix) were used to investigate BCL11b low and high expressing T-ALL patients.
Results: We demonstrate that BCL11b is aberrantly expressed in T-ALL and gene expression profiles reveal an association of low BCL11b expression with up-regulation of immature markers. T-ALL patients characterized by low BCL11b expression exhibit an adverse prognosis [5-year overall survival (OS): low 35% (n = 40) vs. high 53% (n = 129), P = 0.02]. Within the standard risk group of thymic T-ALL (n = 102), low BCL11b expression identified patients with an unexpected poor outcome compared to those with high expression (5-year OS: 20%, n = 18 versus 62%, n = 84, P < 0.01). In addition, sequencing of exon 4 revealed a high mutation rate (14%) of BCL11b.
Conclusions: In summary, our data of a large adult T-ALL patient cohort show that low BCL11b expression was associated with poor prognosis; particularly in the standard risk group of thymic T-ALL. These findings can be utilized for improved risk prediction in a significant proportion of adult T-ALL patients, which carry a high risk of standard therapy failure despite a favorable immunophenotype.
Im Zeitraum 1. 11. 1993 bis 30. 3. 1997 wurden 1149 allgemeinchirurgische Intensivpatienten prospektiv erfaßt, von denen 114 die Kriterien des septischen Schocks erfüllten. Die Letalität der Patienten mit einem septischen Schock betrug 47,3%. Nach Training eines neuronalen Netzes mit 91 (von insgesamt n = 114) Patienten ergab die Testung bei den verbleibenden 23 Patienten bei der Berücksichtigung von Parameterveränderungen vom 1. auf den 2. Tag des septischen Schocks folgendes Ergebnis: Alle 10 verstorbenen Patienten wurden korrekt als nicht überlebend vorhergesagt, von den 13 Überlebenden wurden 12 korrekt als überlebend vorhergesagt (Sensitivität 100%; Spezifität 92,3%).
Myocardial fibrosis and inflammation by CMR predict cardiovascular outcome in people living with HIV
(2021)
Objectives_: The goal of this study was to examine prognostic relationships between cardiac imaging measures and cardiovascular outcome in people living with human immunodeficiency virus (HIV) (PLWH) on highly active antiretroviral therapy (HAART).
Background: PLWH have a higher prevalence of cardiovascular disease and heart failure (HF) compared with the noninfected population. The pathophysiological drivers of myocardial dysfunction and worse cardiovascular outcome in HIV remain poorly understood.
Methods: This prospective observational longitudinal study included consecutive PLWH on long-term HAART undergoing cardiac magnetic resonance (CMR) examination for assessment of myocardial volumes and function, T1 and T2 mapping, perfusion, and scar. Time-to-event analysis was performed from the index CMR examination to the first single event per patient. The primary endpoint was an adjudicated adverse cardiovascular event (cardiovascular mortality, nonfatal acute coronary syndrome, an appropriate device discharge, or a documented HF hospitalization).
Results: A total of 156 participants (62% male; age [median, interquartile range]: 50 years [42 to 57 years]) were included. During a median follow-up of 13 months (9 to 19 months), 24 events were observed (4 HF deaths, 1 sudden cardiac death, 2 nonfatal acute myocardial infarction, 1 appropriate device discharge, and 16 HF hospitalizations). Patients with events had higher native T1 (median [interquartile range]: 1,149 ms [1,115 to 1,163 ms] vs. 1,110 ms [1,075 to 1,138 ms]); native T2 (40 ms [38 to 41 ms] vs. 37 ms [36 to 39 ms]); left ventricular (LV) mass index (65 g/m2 [49 to 77 g/m2] vs. 57 g/m2 [49 to 64 g/m2]), and N-terminal pro–B-type natriuretic peptide (109 pg/l [25 to 337 pg/l] vs. 48 pg/l [23 to 82 pg/l]) (all p < 0.05). In multivariable analyses, native T1 was independently predictive of adverse events (chi-square test, 15.9; p < 0.001; native T1 [10 ms] hazard ratio [95% confidence interval]: 1.20 [1.08 to 1.33]; p = 0.001), followed by a model that also included LV mass (chi-square test, 17.1; p < 0.001). Traditional cardiovascular risk scores were not predictive of the adverse events.
Conclusions: Our findings reveal important prognostic associations of diffuse myocardial fibrosis and LV remodeling in PLWH. These results may support development of personalized approaches to screening and early intervention to reduce the burden of HF in PLWH (International T1 Multicenter Outcome Study; NCT03749343).
By analyzing 6.32 fb − 1 of e+ e− annihilation data collected at the center-of-mass energies between 4.178 and 4.226 GeV with the BESIII detector, we determine the branching fraction of the leptonic decay D + s → τ + ντ, with τ+ → π + π0¯ντ, to be B D + s → τ + ν τ = (5.29 ± 0.25 stat ± 0.20 syst) %. We estimate the product of the Cabibbo-Kobayashi-Maskawa matrix element |Vcs|and the D + s decay constant f D + s to be f D + s|Vcs| = (244.8 ± 5.8 stat ± 4.8syst) MeV, using the known values of the τ + and D + s masses as well as the D + s lifetime, together with our branching fraction measurement. Combining the value of |Vcs| obtained from a global fit in the standard model and f D + s from lattice quantum chromodynamics, we obtain f D + s = (251.6 ± 5.9 stat ± 4.9syst) MeV and |Vcs| = 0.980 ± 0.023 stat ± 0.019 syst. Using the branching fraction of B D + s → μ + νμ = (5.35±0.21)×10−3, we obtain the ratio of the branching fractions B D + s → τ + ντ/B D +s → μ+νμ = 9.89±0.71, which is consistent with the standard model prediction of lepton flavor universality.
Using a data sample of e+e− collision data corresponding to an integrated luminosity of 2.93 fb−1 collected with the BESIII detector at a center-of-mass energy of s=3.773GeV, we search for the singly Cabibbo-suppressed decays D0→π0π0π0, π0π0η, π0ηη and ηηη using the double tag method. The absolute branching fractions are measured to be B(D0→π0π0π0)=(2.0±0.4±0.3)×10−4, B(D0→π0π0η)=(3.8±1.1±0.7)×10−4 and B(D0→π0ηη)=(7.3±1.6±1.5)×10−4 with the statistical significances of 4.8σ, 3.8σ and 5.5σ, respectively, where the first uncertainties are statistical and the second ones systematic. No significant signal of D0→ηηη is found, and the upper limit on its decay branching fraction is set to be B(D0→ηηη)<1.3×10−4 at the 90% confidence level.
The baryonic decay D+s→pn¯ is observed, and the corresponding branching fraction is measured to be (1.21±0.10±0.05)×10−3, where the first uncertainty is statistical and second systematic. The data sample used in this analysis was collected with the BESIII detector operating at the BEPCII e+e− double-ring collider with a center-of-mass energy of 4.178~GeV and an integrated luminosity of 3.19~fb−1. The result confirms the previous measurement by the CLEO Collaboration and is of greatly improved precision, which may deepen our understanding of the dynamical enhancement of the W-annihilation topology in the charmed meson decays.
Using a sample of 1.31×109 J/ψ events collected by the BESIII detector at BEPCII during 2009 and 2012, we study the J/ψ→ωη′π+π− hadronic process. For the first time, we measure the branching ratio B(J/ψ→ωη′π+π−)=(1.12±0.02±0.13)×10−3. We search for the X(1835) state in the η′π+π− invariant mass spectra. No evidence is found and we estimate the upper limit on the branching fraction at 90% confidence level to be B(J/ψ→ωX(1835),X(1835)→η′π+π−)<6.2×10−5.
Several intermediate states of the reaction channels 𝑒+𝑒−→𝜋+𝜋−𝐷0¯𝐷0 and 𝑒+𝑒−→𝜋+𝜋−𝐷+𝐷− are studied using the data samples collected with the BESIII detector at center-of-mass energies above 4.08 GeV. For the first time in this final state, a 𝜓(3770) signal is seen in the 𝐷¯𝐷 invariant mass spectrum, with a statistical significance of 5.2𝜎 at √𝑠=4.42 GeV. There is also evidence for this resonance at √𝑠=4.26 and 4.36 GeV with statistical significance of 3.2𝜎 and 3.3𝜎, respectively. In addition, the Born cross section of 𝑒+𝑒−→𝜋+𝜋−𝜓(3770) is measured. The proposed heavy-quark-spin-symmetry partner of the 𝑋(3872), the state 𝑋2(4013), is also searched for in the 𝐷¯𝐷 invariant mass spectra. No obvious signal is found. The upper limit of the Born cross section of the process 𝑒+𝑒−→𝜌0𝑋2(4013) combined with the branching fraction is measured. Also, the processes 𝑒+𝑒−→𝐷1(2420)¯𝐷+c.c. are investigated. The neutral mode with 𝐷1(2420)0→𝐷0𝜋+𝜋− is reported with statistical significance of 7.4𝜎 at √𝑠=4.42 GeV for the first time, and evidence with statistical significance of 3.2𝜎 and 3.3𝜎 at √𝑠=4.36 and 4.60 GeV is seen, respectively. No evident signal for the process 𝑒+𝑒−→𝐷1(2420)0¯𝐷0+c.c.,𝐷1(2420)0→𝐷*+𝜋− is reported. Evidence for 𝑒+𝑒−→𝐷1(2420)+𝐷−+c.c.,𝐷1(2420)+→𝐷+𝜋+𝜋− is reported with statistical significance of 3.1𝜎 and 3.0𝜎 at √𝑠=4.36 and 4.42 GeV, respectively.
The SU(3)-flavor violating decay J/ψ→Ξ(1530)−Ξ¯++c.c. is studied using (1310.6±7.0)×106 J/ψ events collected with the BESIII detector at BEPCII and the branching fraction is measured to be B(J/ψ→Ξ(1530)−Ξ¯++c.c.) = (3.17±0.02stat.±0.08syst.)×10−4. This is consistent with previous measurements with an improved precision. The angular parameter for this decay is measured for the first time and is found to be α=−0.21±0.04stat.±0.06syst.. In addition, we report evidence for the radiative decay Ξ(1530)−→γΞ− with a significance of 3.9σ, including the systematic uncertainties. The 90\% confidence level upper limit on the branching fraction is determined to be B(Ξ(1530)−→γΞ−)≤3.7\%.
Using a total of 11.0 fb−1 of e+e− collision data with center-of-mass energies between 4.009 GeV and 4.6 GeV and collected with the BESIII detector at BEPCII, we measure fifteen exclusive cross sections and effective form factors for the process e+e−→Ξ−Ξ¯+ by means of a single baryon-tag method. After performing a fit to the dressed cross section of e+e−→Ξ−Ξ¯+, no significant ψ(4230) or ψ(4260) resonance is observed in the Ξ−Ξ¯+ final states, and upper limits at the 90\% confidence level on ΓeeB for the processes ψ(4230)/ψ(4260)→Ξ−Ξ¯+ are determined. In addition, an excited Ξ baryon at 1820 MeV/c2 is observed with a statistical significance of 6.2 ∼ 6.5σ by including the systematic uncertainty, and the mass and width are measured to be M=(1825.5±4.7±4.7)~MeV/c2 and Γ=(17.0±15.0±7.9)~MeV, which confirms the existence of the JP=32− state Ξ(1820).
We report a measurement of the observed cross sections of e+ e− → J/ψX based on 3.21 fb − 1 of data accumulated at energies from 3.645 to 3.891 GeV with the BESIII detector operated at the BEPCII collider. In analysis of the cross sections, we measured the decay branching fractions of B(ψ(3686) → J/ψX) = (64.4 ± 0.6 ± 1.6)% and B(ψ(3770) → J/ψX) = (0.5 ± 0.2 ± 0.1)% for the first time. The energy-dependent line shape of these cross sections cannot be well described by two Breit-Wigner (BW) amplitudes of the expected decays ψ (3686) → J/ψX and ψ(3770) → J/ψX. Instead, it can be better described with one more BW amplitude of the decay R(3760)→ J/ψX. Under this assumption, we extracted the R (3760) mass M R (3760 ) = 3766.2 ± 3.8 ± 0.4 MeV/c2, total width Γ tot R ( 3760 ) = 22.2 ± 5.9 ± 1.4 MeV, and product of leptonic width and decay branching fraction
ΓeeR(3760) B[R(3760) → J/ψX] = (79.4 ± 85.5 ± 11.7) eV. The significance of the R(3760) is 5.3σ. The first uncertainties of these measured quantities are from fits to the cross sections and second systematic.
Using a total of 9.0 fb−1 of e+e− collision data with center-of-mass energies between 4.15 and 4.30 GeV collected by the BESIII detector, we search for the processes e+e−→γX(3872) with X(3872)→π0χcJ for J=0,1,2. We report the first observation of X(3872)→π0χc1, a new decay mode of the X(3872), with a statistical significance of more than 5σ. Normalizing to the previously established process e+e−→γX(3872) with X(3872)→π+π−J/ψ, we find B(X(3872)→π0χc1)/B(X(3872)→π+π−J/ψ)=0.88+0.33−0.27±0.10, where the first error is statistical and the second is systematic. We set 90% confidence level upper limits on the corresponding ratios for the decays to π0χc0 and π0χc2 of 19 and 1.1, respectively.
We search for rare decays of D mesons to hadrons accompany with an electron-positron pair (h(h')e+e−), using an e+e− collision sample corresponding to an integrated luminosity of 2.93 fb−1 collected with the BESIII detector at s√ = 3.773 GeV. No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10−5∼10−6, providing a large improvement over previous searches.
Using 448.1 × 106 ψ(3686) events collected with the BESIII detector at BEPCII, we employ a single-baryon tagging technique to make the first observation of ψ(3686) → Ξ(1530)−Ξ¯(1530)+ and Ξ(1530)−Ξ¯+ decays with a statistical significance of more than 10σ and 5.0σ, respectively. The branching fractions are measured to be B[ψ(3686)→Ξ(1530)−Ξ¯(1530)+] = (11.45 ± 0.40 ± 0.59) × 10−5 and B[ψ(3686)→Ξ(1530)−Ξ¯+] = (0.70 ± 0.11 ± 0.04) × 10−5. The angular distribution parameter for ψ(3686) → Ξ(1530)−Ξ¯(1530)+ is determined to be α = 0.40 ± 0.24 ± 0.06, which agrees with the theoretical predictions within 1σ. The first uncertainties are statistical, and the second systematic.
Measurement of e⁺e⁻ → KK̄J/ψ cross sections at center-of-mass energies from 4.189 to 4.600 GeV
(2018)
We investigate the process e+e−→KK¯J/ψ at center-of-mass energies from 4.189 to 4.600 GeV using 4.7 fb−1 of data collected by the BESIII detector at the BEPCII collider. The Born cross sections for the reactions e+e−→K+K−J/ψ and K0SK0SJ/ψ are measured as a function of center-of-mass energy. The energy dependence of the cross section for e+e−→K+K−J/ψ is shown to differ from that for π+π−J/ψ in the region around the Y(4260). In addition, there is evidence for a structure around 4.5 GeV in the e+e−→K+K−J/ψ cross section that is not present in π+π−J/ψ.
The Born cross section for the process e+e−→pp¯ is measured using the initial state radiation technique with an undetected photon. This analysis is based on datasets corresponding to an integrated luminosity of 7.5 fb−1, collected with the BESIII detector at the BEPCII collider at center of mass energies between 3.773 and 4.600 GeV. The Born cross section for the process e+e−→pp¯ and the proton effective form factor are determined in the pp¯ invariant mass range between 2.0 and 3.8 GeV/c2 divided into 30 intervals. The proton form factor ratio (|GE|/|GM|) is measured in 3 intervals of the pp¯ invariant mass between 2.0 and 3.0 GeV/c2.
Based on a data sample of (448.1±2.9)×106 ψ(3686) decays collected with the BESIII experiment, a search for the flavor changing neutral current transition ψ(3686) → Λ+cp¯¯¯e+e−+c.c. is performed for the first time. No signal candidates are observed and the upper limit on the branching fraction of ψ(3686) → Λ+cp¯¯¯e+e− is determined to be 1.7×10−6 at the 90\% confidence level. The result is consistent with expectations from the Standard Model, and no evidence for new physics is found.
Using a data sample of (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider, we present measurements of branching fractions for the decays χcJ→Σ+Σ¯− and Σ0Σ¯0. The decays χc1,2→Σ+Σ¯− and Σ0Σ¯0 are observed for the first time, and the branching fractions for χc0→Σ+Σ¯− and Σ0Σ¯0 decays are measured with improved precision. The branching fraction ratios between the charged and neutral modes are consistent with the prediction of isospin symmetry.
Using an e+e− annihilation data sample corresponding to an integrated luminosity of 2.93fb−1 collected at the center-of-mass energy of 3.773\,GeV with the BESIII detector, we measure the absolute branching fractions of D+→ηηπ+, D+→ηπ+π0, and D0→ηπ+π− to be (2.96±0.24±0.13)×10−3, (2.23±0.15±0.11)×10−3, and (1.20±0.07±0.04)×10−3, respectively, where the first uncertainties are statistical and the second ones systematic. The D+→ηηπ+ decay is observed for the first time and the branching fractions of D+(0)→ηπ+π0(−) are measured with much improved precision. In addition we test for CP asymmetries in the separated charge-conjugate branching fractions; no evidence of CP violation is found.
Using a data sample of (448.1±2.9)×106 ψ(3686) decays collected by the BESIII detector at the Beijing Electron Positron Collider (BEPCII), we observe the decays χcJ→ϕϕη (J=0, 1, 2), where the χcJ are produced via the radiative processes ψ(3686)→γχcJ. The branching fractions are measured to be B(χc0→ϕϕη)=(8.41±0.74±0.62)×10−4, B(χc1→ϕϕη)=(2.96±0.43±0.22)×10−4, and B(χc2→ϕϕη)=(5.33±0.52±0.39)×10−4, where the first uncertainties are statistical and the second are systematic. We also search for intermediate states in the ϕϕ or ηϕ combinations, but no significant structure is seen due to the limited statistics.
We report the first observation of D+→τ+ντ with a significance of 5.1σ. We measure B(D+→τ+ντ)=(1.20±0.24stat.±0.12syst.)×10−3. Taking the world average B(D+→μ+νμ)=(3.74±0.17)×10−4, we obtain Rτ/μ=Γ(D+→τ+ντ)/Γ(D+→μ+νμ)=3.21±0.64stat.±0.43syst., which is consistent with the Standard Model expectation of lepton flavor universality. Using external inputs, our results give values for the D+ decay constant fD+ and the CKM matrix element |Vcd| that are consistent with, but less precise than, other determinations.
A search for the rare radiative leptonic decay D+s→γe+νe is performed for the first time using electron-positron collision data corresponding to an integrated luminosity of 3.19 fb−1, collected with the BESIII detector at a center-of-mass energy of 4.178 GeV. No evidence for the D+s→γe+νe decay is seen and an upper limit of B(D+s→γe+νe)<1.3×10−4 is set on the partial branching fraction at a 90\% confidence level for radiative photon energies E∗γ>0.01~GeV.