Refine
Author
- Buxbaum, Joseph D. (5)
- Gill, Michael (5)
- Haines, Jonathan L. (5)
- Hakonarson, Hakon (5)
- Pericak-Vance, Margaret Ann (5)
- Schellenberg, Gerard D. (5)
- Almeida, Joana (4)
- Anney, Richard (4)
- Bacchelli, Elena (4)
- Bailey, Anthony J. (4)
- Baird, Gillian (4)
- Battaglia, Agatino (4)
- Betancur, Catalina (4)
- Bolshakova, Nadia (4)
- Bolton, Patrick F. (4)
- Bourgeron, Thomas (4)
- Brennan, Sean (4)
- Cook, Edwin H. (4)
- Coon, Hilary (4)
- Cuccaro, Michael L. (4)
- Dawson, Geraldine (4)
- Delorme, Richard (4)
- Duketis, Eftichia (4)
- Duque, Frederico (4)
- Engeland, Herman van (4)
- Ennis, Sean (4)
- Fernandez, Bridget A. (4)
- Folstein, Susan E. (4)
- Freitag, Christine M. (4)
- Gallagher, Louise (4)
- Geschwind, Daniel H. (4)
- Gilbert, John (4)
- Gillberg, Christopher (4)
- Green, Jonathan (4)
- Guter, Stephen J. (4)
- Hallmayer, Joachim (4)
- Holt, Richard (4)
- Jonge, Maretha de (4)
- Klauck, Sabine M. (4)
- Kolevzon, Alexander (4)
- Le Couteur, Ann (4)
- Leboyer, Marion (4)
- Lord, Catherine (4)
- Maestrini, Elena (4)
- Magalhães, Tiago R. (4)
- Merikangas, Alison (4)
- Monaco, Anthony P. (4)
- Nurnberger, John I. (4)
- Oliveira, Guiomar (4)
- Pagnamenta, Alistair T. (4)
- Parr, Jeremy R. (4)
- Pinto, Dalila (4)
- Poustka, Fritz (4)
- Regan, Regina (4)
- Roge, Bernadette (4)
- Scherer, Stephen W. (4)
- Soorya, Latha (4)
- Sutcliffe, James S. (4)
- Szatmari, Peter (4)
- Thompson, Ann P. (4)
- Thomson, Susanne (4)
- Vicente, Astrid M. (4)
- Vieland, Veronica J. (4)
- Wallace, Simon (4)
- Wijsman, Ellen M. (4)
- Wing, Kirsty (4)
- Wittemeyer, Kerstin (4)
- Zwaigenbaum, Lonnie (4)
- Ansaloni, Luca (3)
- Balogh, Zsolt J. (3)
- Berking, Carola (3)
- Biffl, Walter (3)
- Bölte, Sven (3)
- Cantor, Rita M. (3)
- Catena, Fausto (3)
- Ceresoli, Marco (3)
- Chiara, Osvaldo (3)
- Coccolini, Federico (3)
- Coimbra, Raul (3)
- Conroy, Judith (3)
- Correia, Catarina (3)
- Corsello, Christina (3)
- Crawford, Emily L. (3)
- De Moya, Marc (3)
- Devlin, Bernie (3)
- Di Saverio, Salomone (3)
- Estes, Annette (3)
- Farrar, Penny (3)
- Fombonne, Eric (3)
- Fraga, Gustavo Pereira (3)
- Glessner, Joseph T. (3)
- Green, Andrew (3)
- Howe, Jennifer L. (3)
- Hughes, Gillian (3)
- Hus, Vanessa (3)
- Igliozzi, Roberta (3)
- Ivatury, Rao (3)
- Kashuk, Jeffry L. (3)
- Khokha, Vladimir (3)
- Kim, Cecilia (3)
- Klei, Lambertus (3)
- Kluger, Yoram (3)
- Kähler, Katharina C. (3)
- Lamb, Janine A. (3)
- Latifi, Rifat (3)
- Leventhal, Bennett L. (3)
- Loquai, Carmen (3)
- Lund, Sabata C. (3)
- Mantoulan, Carine (3)
- Marshall, Christian R. (3)
- McDougle, Christopher J. (3)
- McMahon, William M. (3)
- Miller, Judith (3)
- Minshew, Nancy J. (3)
- Mirza, Ghazala K. (3)
- Moore, Ernest E. (3)
- Munson, Jeff (3)
- Nelson, Stanley F. (3)
- Nygren, Gudrun (3)
- Papanikolaou, Katerina (3)
- Parrini, Barbara (3)
- Paterson, Andrew D. (3)
- Pickles, Andrew (3)
- Piven, Joseph (3)
- Posey, David J. (3)
- Ragoussis, Jiannis (3)
- Roberts, Wendy (3)
- Rutter, Michael L. (3)
- Sakakushev, Boris (3)
- Sartelli, Massimo (3)
- Scalea, Thomas (3)
- Shah, Naisha (3)
- Sousa, Inês (3)
- Stoppioni, Vera (3)
- Sugrue, Michael (3)
- Sykes, Nuala (3)
- Tancredi, Raffaella (3)
- Tryfon, Ana (3)
- Tsiantis, John (3)
- Velmahos, George C. (3)
- Vincent, John B. (3)
- Volkmar, Fred (3)
- Wani, Imtiaz (3)
- Wassink, Thomas H. (3)
- Abayazeed, Aly (2)
- Abbassy, Ahmed (2)
- Abello, Ana Lorena (2)
- Abrahams, Brett S. (2)
- Adabi, Saba (2)
- Agresta, Ferdinando (2)
- Agzarian, Marc (2)
- Ahn, Sung Soo (2)
- Ak, Murat (2)
- Alafandi, Ahmed (2)
- Alexander, Gregory S. (2)
- Alexiou, Sotiris (2)
- Allegri, Andrea (2)
- Allen, Bryan (2)
- Amin, Najaf (2)
- Apgar, Charles (2)
- Badve, Chaitra (2)
- Baek, Stephen (2)
- Baid, Ujjwal (2)
- Bailey, Ian (2)
- Bakas, Spyridon (2)
- Balaña, Carmen (2)
- Bangalore Yogananda, Chandan Ganesh (2)
- Bapuraj, Jayapalli Rajiv (2)
- Bareja, Rohan (2)
- Barnholtz-Sloan, Jill S. (2)
- Baumgarten, Peter (2)
- Beets-Tan, Regina G. H. (2)
- Behmanesh, Bedjan (2)
- Belouali, Anas (2)
- Bencheqroun, Camelia (2)
- Bendinelli, Cino (2)
- Bendszus, Martin (2)
- Benson, Sean (2)
- Bernal, Jose (2)
- Berney, Tom (2)
- Bernstock, Joshua D. (2)
- Bhardwaj, Sargam (2)
- Bhuvaneshwar, Krithika (2)
- Bialecki, Brian (2)
- Bilello, Michel (2)
- Bink, Andrea (2)
- Bonavina, Luigi (2)
- Booth, Thomas C. (2)
- Borzellino, Giuseppe (2)
- Boss, Michael A. (2)
- Brian, Jessica (2)
- Brugnara, Gianluca (2)
- Brunetti, Francesco (2)
- Buatti, John M. (2)
- Burlew, Clay Cothren (2)
- Calabrese, Evan (2)
- Camapanelli, Giampiero (2)
- Campanile, Fabio Cesare (2)
- Capellades, Jaume (2)
- Casey, Jillian (2)
- Casey, Jillian P. (2)
- Cha, Soonmee (2)
- Chambless, Lola B. (2)
- Chang, Jong Hee (2)
- Chang, Ken (2)
- Chelliah, Alysha (2)
- Chen, Cheng (2)
- Chen, Jonathan (2)
- Choi, Joseph (2)
- Choi, Yoon Seong (2)
- Chong, Chee (2)
- Chotai, Silky (2)
- Cimino, Lisa (2)
- Civil, Ian (2)
- Cloughesy, Timothy F. (2)
- Colen, Rivka R. (2)
- Currie, Stuart (2)
- Cutler, Danielle (2)
- Dako, Farouk (2)
- Davatzikos, Christos (2)
- Del Zompo, Maria (2)
- Dicker, Adam P. (2)
- Dixon, Luke V. M. (2)
- Dorcas, Adeleye (2)
- Dostál, Marek (2)
- Dou, Qi (2)
- Dragos, Carmen (2)
- Dubbink, Hendrikus J. (2)
- Dubinski, Daniel (2)
- Duijn, Cornelia M. van (2)
- Edwards, Brandon (2)
- Eigentler, Thomas Kurt (2)
- Ellingson, Benjamin M. (2)
- Escobar, William (2)
- Ezhov, Ivan (2)
- Falcão, Alexandre Xavier (2)
- Farinhas, Joaquim (2)
- Fatania, Kavi (2)
- Fingerhut, Abe (2)
- Flanders, Adam E. (2)
- Foley, Patrick (2)
- Fortin, David (2)
- Franco-Maldonado, Heydy (2)
- Freiman, Thomas Michael (2)
- French, Pim J. (2)
- Frood, Russell (2)
- Fu, Eric (2)
- Gahrmann, Renske (2)
- Gamal, Shady (2)
- Garrett, John (2)
- Geßler, Florian (2)
- Ghodasara, Satyam (2)
- Gimpel, James (2)
- Glocker, Ben (2)
- Gruzdev, Alexey (2)
- Guevara, Pamela (2)
- Gupta, Sanjay (2)
- Gurusamy, Kurinchi S. (2)
- Gusev, Yuriy (2)
- Gutzmer, Ralf (2)
- Gómez, Jhon (2)
- Haas, Rourke (2)
- Hagiwara, Akifumi (2)
- Haliassos, Ilias (2)
- Hamghalam, Mohammad (2)
- Harris, Tamara B. (2)
- Harter, Patrick Nikolaus (2)
- Hassel, Jessica C. (2)
- Hau, Ann-Christin (2)
- Haunschmidt, Andreas (2)
- Heinzerling, Lucie (2)
- Heng, Pheng Ann (2)
- Heppt, Markus V. (2)
- Heron, Elizabeth A. (2)
- Herrera-Trujillo, Alejandro (2)
- Hill, Michael (2)
- Hofman, Albert (2)
- Holcomb, James (2)
- Hu, Ricky (2)
- Huang, Raymond Y. (2)
- Incekara, Fatih (2)
- Ingalhalikar, Madhura (2)
- Ismael, Heba (2)
- Jacob, Suma (2)
- Jadhav, Manali (2)
- Jain, Rajan (2)
- Jayachandran Preetha, Chandrakanth (2)
- Jeekel, Hans (2)
- Jeraj, Robert (2)
- Jiang, Meirui (2)
- Jones, Craig K. (2)
- Kalogeropoulou, Christina (2)
- Kamnitsas, Konstantinos (2)
- Kapsas, Georgios (2)
- Kardamakis, Dimitrios M. (2)
- Karkada, Deepthi (2)
- Kattil Veettil, Deepak (2)
- Kelly, Michael Denis (2)
- Keunen, Olivier (2)
- Keřkovský, Miloš (2)
- Kim, Ho Sung (2)
- Kim, Yusung (2)
- Klein, Stefan (2)
- Kofler, Florian (2)
- Kolodziej, Kenneth (2)
- Kopřivová, Tereza (2)
- Kotrotsou, Aikaterini (2)
- Kozubek, Michal (2)
- Kumar, Neeraj (2)
- Kurc, Tahsin (2)
- Kustanovich, Vlad (2)
- LaMontagne, Pamela (2)
- Lajonchere, Clara M. (2)
- Landman, Bennett (2)
- Larson, Matthew (2)
- Lee, Joonsang (2)
- Lee, Matthew (2)
- Lee, Seung-Koo (2)
- Lepage, Martin (2)
- Leppäniemi, Ari Kalevi (2)
- Li, Hongwei (2)
- Liem, Spencer (2)
- Liu, Xiao-Qing (2)
- Loayza, Francis (2)
- Lombardo, Joseph (2)
- Lotspeich, Linda (2)
- Lucio, Diego R. (2)
- Lui, Yvonne W. (2)
- Luo, Bing (2)
- Lux, Filip (2)
- López, Eduardo (2)
- Madhavan, Subha (2)
- Mahajan, Abhishek (2)
- Maier, Ronald V. (2)
- Maier-Hein, Klaus (2)
- Maldjian, Joseph A. (2)
- Mandel, Jacob (2)
- Mani, Kartik M. (2)
- Marcus, Daniel (2)
- Marella, Sailaja (2)
- Martin, Jason (2)
- Martins, Samuel B. (2)
- Marzi, Ingo (2)
- Matula, Petr (2)
- McConachie, Helen (2)
- McGrath, Jane (2)
- McKinley, Richard (2)
- Meckel, Stephan (2)
- Meier, Friedegund (2)
- Meier, Raphael (2)
- Meissner, Markus (2)
- Mekhaimar, Mahmoud (2)
- Melhem, Nadine M. (2)
- Mendoza, Cristobal (2)
- Menotti, David (2)
- Menze, Bjoern Holger (2)
- Metz, Marie (2)
- Michálek, Jan (2)
- Mistry, Akshitkumar (2)
- Mitchell, J. Ross (2)
- Modat, Marc (2)
- Moebus, Susanne (2)
- Mohan, Suyash (2)
- Mohr, Peter (2)
- Moore, Frederick Alan (2)
- Moraes, Fabio Y. (2)
- Moritani, Toshio (2)
- Morón, Fanny (2)
- Moustakas, Konstantinos (2)
- Murcia, Derrick (2)
- Muzi, Mark (2)
- Necker, Georg (2)
- Ngassam, Lionel D. C. (2)
- Niclou, Simone P. (2)
- Noakes, Carolyn (2)
- Nöthen, Markus Maria (2)
- O'Donovan, Michael C. (2)
- Odafe-Oyibotha, Olubunmi (2)
- Ogbole, Godwin (2)
- Ormond, David Ryan (2)
- Osobu, Babatunde (2)
- Oughourlian, Talia (2)
- Owen, Michael J. (2)
- Oyekunle, Dotun (2)
- Palmer, Joshua D. (2)
- Panagiotopoulos, Vasileios (2)
- Pandey, Umang (2)
- Park, Ji Eun (2)
- Pati, Sarthak (2)
- Paton, Tara (2)
- Payne, David (2)
- Pei, Linmin (2)
- Peitzmann, Andrew B. (2)
- Pelaez, Enrique (2)
- Peoples, Jacob J. (2)
- Pföhler, Claudia Ursula (2)
- Piazzalunga, Dario (2)
- Pichler, Josef (2)
- Pinho, Marco C. (2)
- Pisano, Michele (2)
- Poisson, Laila (2)
- Poustka, Annemarie (2)
- Pouymayou, Bertrand (2)
- Prabhudesai, Snehal (2)
- Prasanna, Prateek (2)
- Price, Cynthia (2)
- Puig, Josep (2)
- Qayati, Mohamed (2)
- Quevedo Sacoto, Andrés Sebastián (2)
- Radojewski, Piotr (2)
- Ramadass, Karthik (2)
- Rao, Arvind (2)
- Rauch, Maximilian (2)
- Raymond, Catalina (2)
- Reddy, Divya (2)
- Reina, G. Anthony (2)
- Reyes, Mauricio (2)
- Roeder, Kathryn (2)
- Rudie, Jeffrey (2)
- Ríos, Elvis (2)
- Sahm, Felix (2)
- Saini, Jitender (2)
- Sair, Haris I. (2)
- Sako, Chiharu (2)
- Saltz, Joel (2)
- Sayah, Anousheh (2)
- Schadendorf, Dirk (2)
- Schmidt, Kendall (2)
- Schouten, Joost W. (2)
- Schuler-Thurner, Beatrice (2)
- Senft, Christian (2)
- Shah, Prashant (2)
- Sharma, Sonam (2)
- Shaykh, Hassan F. (2)
- Sheffield, Val C. (2)
- Sheller, Micah (2)
- Shrestha, Sampurna (2)
- Shuaib, Haris (2)
- Shukla, Gaurav (2)
- Shu’aibu, Mustapha (2)
- Simpson, Amber L. (2)
- Sloan, Andrew E. (2)
- Slotboom, Johannes (2)
- Smits, Marion (2)
- So, Tiffany Y. (2)
- Soneye, Mayowa (2)
- Sprenger, Flávia (2)
- Srinivasan, Ashok (2)
- Stahel, Philip F. (2)
- Taviloglu, Korhan (2)
- Teixeira, Bernardo Corrêa de Almeida (2)
- Terheyden, Patrick (2)
- Teuwen, Jonas (2)
- Thompson, John (2)
- Thompson, Reid C. (2)
- Thoms, Kai-Martin (2)
- Tiwari, Pallavi (2)
- To, Minh-Son (2)
- Torche, Esteban (2)
- Tran, Anh (2)
- Trenkler, Johannes (2)
- Trujillo, Maria (2)
- Tseng, Tzu-Chi (2)
- Tsiganos, Panagiotis (2)
- Tugnoli, Gregorio (2)
- Turk, Sevcan (2)
- Ulrich, Jens (2)
- Uranüs, Selman (2)
- Utikal, Jochen (2)
- Vadmal, Vachan (2)
- Vallières, Martin (2)
- Van den Bent, Martin J. (2)
- Velastin, Sergio Alejandro (2)
- Venkataraman, Archana (2)
- Vera, Franco (2)
- Verma, Ruchika (2)
- Viale, Pierluigi (2)
- Villanueva-Meyer, Javier (2)
- Vincent, Arnaud J. P. E. (2)
- Vogelbaum, Michael A. (2)
- Vollmuth, Philipp (2)
- Voort, Sebastian R. van der (2)
- Vorstman, Jacob A. S. (2)
- Vybíhal, Václav (2)
- Wagner, Benjamin C. (2)
- Waite, Kristin (2)
- Wang, Chencai (2)
- Wang, Kai (2)
- Wang, Nicholas (2)
- Wang, Shih-Han (2)
- Weber, Dieter G. (2)
- Weiss, Tobias (2)
- Weller, Michael (2)
- Wen, Ning (2)
- Wick, Wolfgang (2)
- Wiest, Roland Gerhard Rudi (2)
- Wiestler, Benedikt (2)
- Wijnenga, Maarten M. J. (2)
- Williams, Matthew (2)
- Won, Sae-Yeon (2)
- Wood, Shawn (2)
- Xu, Kaiwen (2)
- Yadav, Ipsa (2)
- Yaspan, Brian L. (2)
- Yoshiaki, Ota (2)
- Yuan, Yading (2)
- Yun, Jihye (2)
- Zacharaki, Evangelia I. (2)
- Zampakis, Peter (2)
- Zenk, Maximilian (2)
- Zurawiecki, Danielle (2)
- Aase, Hildegunn S. (1)
- Abecasis, Gonçalo R. (1)
- Absher, Devin (1)
- Abu-Zidan, Fikri M. (1)
- Achtyes, Eric D. (1)
- Adamson, Maheen (1)
- Agaoglu, Esen (1)
- Agnoletti, Vanni (1)
- Ahlmann, M (1)
- Al-Shahi Salman, Rustam (1)
- AlEissa, Sami (1)
- Albert, Michael H. (1)
- Albrecht, Eva (1)
- Alda, Martin (1)
- Aleinikova, O (1)
- Alonso, CN (1)
- Alonso-Lana, Silvia (1)
- Alqahtani, Yahya (1)
- Alsebayel, Hana (1)
- Alturkistany, Ahmed (1)
- Altınbaş, Kürşat (1)
- Alvarez, Victoria (1)
- Amaral, Teresa (1)
- Ambrogi, Sonia (1)
- Amouyel, Philippe (1)
- Anagnostou, Evdokia (1)
- Anderson, Craig S. (1)
- Anderson, Denise (1)
- Anderson, Tim J. (1)
- Andreassen, Ole A. (1)
- Angelopoulos, Elias (1)
- Ankermann, Tobias (1)
- Arand, Markus (1)
- Arango, Celso (1)
- Archer, P (1)
- Ardau, Raffaella (1)
- Arima, Hisatomi (1)
- Arrua Vares, Edgar (1)
- Arveiler, Dominique (1)
- Arvieux, Catherine (1)
- Asarnow, Robert F. (1)
- Assimes, Themistocles L. (1)
- Atalay, Mustafa (1)
- Atschekzei, Faranaz (1)
- Attwood, Antony Paul (1)
- Auce, Pauls (1)
- Avbersek, Andreja (1)
- Avila, Anne (1)
- Aviv, Richard I. (1)
- Avram, Mihai (1)
- Aydin, Memduha (1)
- Ayesa-Arriola, Rosa (1)
- Ayhan, Yavuz (1)
- Ayres, Alison M. (1)
- Azavedo, Edward (1)
- Baarslag, Henk J. (1)
- Babikian, Talin (1)
- Bader, Peter (1)
- Baethge, Christopher Jan (1)
- Bakhtiar, Shahrzad (1)
- Bakker, Stephan J. L. (1)
- Bala, Miklosh (1)
- Balaban, Ceylan (1)
- Baldwin, Clinton (1)
- Ballerini, P (1)
- Balleyguier, Corinne (1)
- Baltzer, Pascal Andreas Thomas (1)
- Banaj, Nerisa (1)
- Barberger-Gateau, Pascale (1)
- Barbosa, Mafalda (1)
- Barlassina, Cristina (1)
- Barroso, Inês (1)
- Basart, Hanneke (1)
- Basu, Saumyajit (1)
- Battey, Thomas W. K. (1)
- Bauer, Michael (1)
- Bauer, Rita (1)
- Bauer, Sabrina (1)
- Baumann, Ulrich (1)
- Baune, Bernhard T. (1)
- Bayer, Anthony (1)
- Becerra-Palars, Claudia (1)
- Becker, Felicitas (1)
- Becker, Tim (1)
- Beckmann, Jacques S. (1)
- Beecham, Gary W. (1)
- Beekly, Duane (1)
- Behere, Aniruddh P. (1)
- Behere, Prakash B. (1)
- Behrends, Uta (1)
- Beider, Renata (1)
- Beilby, John P. (1)
- Belete, Habte (1)
- Belete, Tilahun (1)
- Belizario, Gabriel Okawa (1)
- Bellenguez, Céline (1)
- Bellivier, Frank (1)
- Belmaker, Robert H. (1)
- Belohradsky, Bernd H. (1)
- Benedetti, Francesco (1)
- Bennett, David A. (1)
- Bergmann, Tanja Regina (1)
- Berie, Lisa (1)
- Berk, Michael (1)
- Bernbeck, Benedikt (1)
- Bernier, Raphael (1)
- Bernuth, Horst von (1)
- Berr, Claudine (1)
- Bersudsky, Yuly (1)
- Beslagic, Vanesa (1)
- Bettens, Karolien (1)
- Bicakci, Şule (1)
- Bick, Ulrich (1)
- Biegner, Anika-Kerstin (1)
- Bielack, Stefan S. (1)
- Bierut, Laura Jean (1)
- Bihoreau, Marie-Thérèse (1)
- Binato, R (1)
- Bing, Camilla (1)
- Birabwa-Oketcho, Harriet (1)
- Bird, Laura J. (1)
- Bis, Joshua C. (1)
- Bismarck, Philipp von (1)
- Bjella, Thomas D. (1)
- Blacker, Deborah (1)
- Blattert, Thomas (1)
- Boada, Mercè (1)
- Bockmeyer, Clemens Luitpold (1)
- Bode, Sebastian (1)
- Boehnke, Michael (1)
- Boerwinkle, Eric (1)
- Boesecke, Christoph (1)
- Boffard, Ken (1)
- Bogdanovic-Stojanovic, Dragana (1)
- Bohlander, Stefan Klaus (1)
- Bolton, Jennifer L. (1)
- Bonnefond, Amélie (1)
- Bonnycastle, Lori L. (1)
- Bonuccelli, Ubaldo (1)
- Boomsma, Dorret I. (1)
- Borecki, Ingrid B. (1)
- Borgwardt, Stefan (1)
- Bornstein, Stefan R. (1)
- Borte, Michael (1)
- Borte, Stephan (1)
- Bosco, Paolo (1)
- Bossù, Paola (1)
- Boucher, Gabrielle (1)
- Brady, Conan (1)
- Brandes, Ralf (1)
- Brayne, Carol (1)
- Brewer, Alison C. (1)
- Brice, Alexis (1)
- Briediene, Ruta (1)
- Brkljacic, Boris (1)
- Broderick, Joseph (1)
- Brodtmann, Amy (1)
- Broeckhoven, Christine Van (1)
- Brosch, Katharina (1)
- Brown, Kristelle (1)
- Bruijn, Renee F. A. G. de (1)
- Brummel, Bastian (1)
- Buechler, Christa (1)
- Bueno, C (1)
- Burmeister, Thomas (1)
- Busari, Jamiu O. (1)
- Bussières, André (1)
- Butcher, Kenneth (1)
- Böhm, Bernhard O. (1)
- Büttner, Thomas G. (1)
- Cabrera, Jorge (1)
- Cabrol, Christelle (1)
- Caeyenberghs, Karen (1)
- Caffarra, Paolo (1)
- Café, Cátia (1)
- Cai, Chunyan (1)
- Cai, Guiqing (1)
- Calhoun, Vince D. (1)
- Cali, Phil (1)
- Callanan, MB (1)
- Campbell, Harry (1)
- Campello, Marco (1)
- Campion, Dominique (1)
- Camps Herrero, Julia (1)
- Cantwell, Laura B. (1)
- Cappucciati, Marco (1)
- Carrasquillo, Minerva M. (1)
- Carson, Andrew R. (1)
- Casallo, Guillermo (1)
- Casey, Graham (1)
- Castillo, José (1)
- Castro, Angela Marianne Paredes (1)
- Caulfield, Mark J. (1)
- Cavalleri, Gianpiero L. (1)
- Cavé, H (1)
- Cayuela, JM (1)
- Cazzaniga, G (1)
- Cerveira, N (1)
- Cesana, Giancarlo (1)
- Chanock, Stephen J. (1)
- Chasman, Daniel I. (1)
- Chaste, Pauline (1)
- Chen, Wei-Ling (1)
- Chen, Yii-Der Ida (1)
- Cheung, Eric Y. Wo (1)
- Chhabra, Harvinder Singh (1)
- Chiaravalloti, Nancy D. (1)
- Chiesa, Silvia (1)
- Chines, Peter S. (1)
- Chirica, Mircea (1)
- Choi, JR (1)
- Choi, Seung-Hoan (1)
- Choi, WW (1)
- Chouraki, Vincent (1)
- Chu, Su H. (1)
- Cifu, David X. (1)
- Cimbanassi, Stefania (1)
- Claassen, Jan (1)
- Clappier, E (1)
- Clarimon, Jordi (1)
- Clarke, Robert (1)
- Classen, Carl Friedrich (1)
- Clegg, Deborah J. (1)
- Cochrane, Lynne (1)
- Coenen, EA (1)
- Colin, Catherine (1)
- Collinge, John (1)
- Collins, Francis S. (1)
- Combarros, Onofre (1)
- Conceição, Inȇs C. (1)
- Connolly, Edward Sander (1)
- Conroy, Judith M. (1)
- Cornford, Eleanor (1)
- Cornillet-Lefebvre, P (1)
- Correia, Catarina T. (1)
- Costanzo, Giuseppe (1)
- Coto, Eliecer (1)
- Cotterchio, Michelle (1)
- Coutanche, Marc (1)
- Craig, David (1)
- Crane, Paul K. (1)
- Crespo-Facorro, Benedicto (1)
- Crossett, Andrew (1)
- Croteau-Chonka, Damien C. (1)
- Crowe, Marie (1)
- Cruchaga, Carlos (1)
- Cuomo, Alessandro (1)
- Cupples, L. Adrienne (1)
- Côté, Pierre (1)
- Dabrowski, Evelyn (1)
- Dallaspezia, Sara (1)
- Dalrymple-Alford, John C. (1)
- Dams-O’Connor, Kristen (1)
- Danes, Jan (1)
- Dannlowski, Udo (1)
- Darby, David (1)
- Dartigues, Jean-François (1)
- Darwano, Bambang (1)
- Davalos, Antonio (1)
- Davenport, Nicholas (1)
- Day, Felix R. (1)
- De Angelis, Nicola (1)
- De Braekeleer, E (1)
- De Braekeleer, M (1)
- DeLuca, John (1)
- DeStefano, Anita L. (1)
- Dedoussis, George (1)
- Delabesse, E (1)
- Delaby, Elsa (1)
- Delanty, Norman (1)
- Delgado, Pilar (1)
- Deloukas, Panos (1)
- Demchuk, Andrew M. (1)
- Demetrashvili, Zaza (1)
- Deniz Naranjo, Maria Candida (1)
- Denning, Nicola (1)
- Dennis, Emily L. (1)
- Denzer, Ulrike (1)
- Depondt, Chantal (1)
- Deramecourt, Vincent (1)
- Dermitzakis, Emmanouil T. (1)
- Desai, Pratikkumar (1)
- Deutz, Peter (1)
- Di Napoli, Mario (1)
- Dietrich, Alexander (1)
- Dietzel, Joanna (1)
- Dilloo, Dagmar (1)
- Dimas, Antigone S. (1)
- Dimitriou, Maria (1)
- Dingermann, Theodor (1)
- Dippel, Edgar (1)
- Diringer, Michael N. (1)
- Dirks, Johannes (1)
- Disner, Seth G. (1)
- Distelrath, Andrea (1)
- Dobryakova, Ekaterina (1)
- Dodd, Seetal (1)
- Dohring, Edward J. (1)
- Dollinger, Matthias (1)
- Dombroski, Beth A. (1)
- Donix, Markus (1)
- Dowlatshahi, Dar (1)
- Drmic, Irene (1)
- Duerr, E. M. (1)
- Dufouil, Carole (1)
- Dummer, Reinhard (1)
- Dunstan, Melanie L. (1)
- Dworzak, Michael N. (1)
- Díaz-Caneja, Covadonga M. (1)
- Dückers, Gregor (1)
- D’Esterre, Christopher D. (1)
- Ebert, Matthias P. (1)
- Eckardt, Kai-Uwe (1)
- Eckert, C (1)
- Edkins, Sarah (1)
- Ehl, Stephan (1)
- Ehrlich, Stefan (1)
- Eichinger, Anna (1)
- Eiriksdottir, Gudny (1)
- Eisinger, Kristina (1)
- Eklund, Niina (1)
- El-Helou, Sabine M. (1)
- Emerenciano, M (1)
- Endres, Matthias (1)
- Erbel, Raimund (1)
- Erdmann, Jeanette (1)
- Eriksson, Johan G. (1)
- Ernst, Diana (1)
- Escott-Price, Valentina (1)
- Esen, Gul (1)
- Esko, Tõnu (1)
- Esopenko, Carrie (1)
- Estrada, Karol (1)
- Etain, Bruno (1)
- Evans, Andrew (1)
- Evans, Denis (1)
- Faber, Kelley M. (1)
- Fagiolini, Andrea (1)
- Faire, Ulf de (1)
- Fall, Tove (1)
- Farrall, Martin (1)
- Farrer, Lindsay A. (1)
- Fasshauer, Maria (1)
- Fechina, L (1)
- Feitosa, Mary F. (1)
- Fellendorf, Frederike Tabea (1)
- Ferensztajn-Rochowiak, Ewa (1)
- Ferrada, Paula (1)
- Ferrarelli, Fabio (1)
- Ferreira, Teresa (1)
- Fiedorowicz, Jess G. (1)
- Filser, Paula (1)
- Fischer, Krista (1)
- Fitzpatrick, Annette L. (1)
- Fiévet, Nathalie (1)
- Fluck, Michael (1)
- Foley, Suzanne (1)
- Foroud, Tatiana M. (1)
- Forrai, Gabor (1)
- Fountoulakis, Kostas N. (1)
- Fowkes, Gerry (1)
- Fox, Caroline S. (1)
- Fox, Nick C. (1)
- Frank, Lea E. (1)
- Frank-García, Ana (1)
- Franke, Jörg (1)
- Franks, Paul W. (1)
- Frantzias, Joseph (1)
- Franz, Carol (1)
- Fraser, Ross M. (1)
- Fratiglioni, Laura (1)
- Frayling, Timothy (1)
- Freichel, Marc (1)
- Froguel, Philippe (1)
- Frye, Mark A. (1)
- Fuchs, Beate (1)
- Fuchsjäger, Michael H. (1)
- Fuentes-Claramonte, Paola (1)
- Fugazzola, Paola (1)
- Fujii, Yukihiko (1)
- Fujimoto, Shigeru (1)
- Föll, Dirk (1)
- Galante, Joseph (1)
- Galimberti, Daniela (1)
- Gallacher, John (1)
- Galle, Peter R. (1)
- Gallinger, Steven (1)
- Gamberini, Emiliano (1)
- Gameiro, P (1)
- Ganna, Andrea (1)
- Garbe, Claus (1)
- Garg, Bhavuk (1)
- Geberzahn, Linda (1)
- Geburtig-Chiocchetti, Andreas (1)
- Geer, Gerard de (1)
- Geißler, Michael (1)
- Gejman, Pablo V. (1)
- Genova, Helen (1)
- Geoffroy, Pierre A. (1)
- Gerrish, Amy (1)
- Gerschmann, Stev (1)
- Gesierich, Anja (1)
- Gesierich, Anja Heike (1)
- Ghofrani, Hossein A. (1)
- Ghosh, Sujal (1)
- Gieger, Christian (1)
- Gigante, Bruna (1)
- Gilbert, Fiona J. (1)
- Girschick, Hermann (1)
- Giza, Christopher C. (1)
- Glenn, Tasha (1)
- Goate, Alison M. (1)
- Godoy, Daniel Agustín (1)
- Goel, Anuj (1)
- Goldberg, Jeremy (1)
- Goldinger, Simone M. (1)
- Goldstein, Joshua Norkin (1)
- Goltermann, Janik (1)
- Gomes, Carlos Augusto (1)
- Gonzalez-Pinto, Ana (1)
- González, Patricia Jiménez (1)
- Gottlieb, John F. (1)
- Grabbe, Stephan (1)
- Graf, Dagmar (1)
- Graf, Norbert (1)
- Graf, Oswald (1)
- Graff, Caroline (1)
- Grallert, Harald (1)
- Greil, Johann (1)
- Grenier-Boley, Benjamin (1)
- Grimbacher, Bodo (1)
- Grimminger, Friedrich (1)
- Griswold, Anthony J. (1)
- Grof, Paul (1)
- Groop, Leif C. (1)
- Grotegerd, Dominik (1)
- Grotta, James C. (1)
- Groß-Wieltsch, Ute (1)
- Gruber, Marius (1)
- Gröger, D (1)
- Grönberg, Henrik (1)
- Gu, Wei (1)
- Gudermann, Thomas (1)
- Gudnason, Vilmundur (1)
- Gustafsson, Stefan (1)
- Gutiérrez-Zotes, Alfonso (1)
- Gyllensten, Ulf (1)
- Göppner, Daniela (1)
- Ha, Minji (1)
- Haarman, Bartholomeus C. M. (1)
- Haase, Gabriele (1)
- Haavik, Jan (1)
- Haenicke, Henriette (1)
- Haferkamp, Sebastian (1)
- Hall, Alistair S. (1)
- Hall, Per (1)
- Hallmans, Göran (1)
- Hamann, Gerhard (1)
- Hamilton-Nelson, Kara L. (1)
- Hampel, Harald (1)
- Hamsten, Anders (1)
- Hancock, J (1)
- Handgretinger, Rupert (1)
- Handolin, Lauri (1)
- Hanitsch, Leif Gunnar (1)
- Hannequin, Didier (1)
- Hanon, Olivier (1)
- Hardy, John (1)
- Hargaden, Gormlaith (1)
- Harima, Hirohiko (1)
- Haritunians, Talin (1)
- Harold, Denise (1)
- Harris, MH (1)
- Harst, Pim van der (1)
- Hartikainen, Anna-Liisa (1)
- Hasan, Rumaisah (1)
- Hasegawa, Hitoshi (1)
- Hasse-Sousa, Mathias (1)
- Hauck, Fabian (1)
- Hauenherm, Anja (1)
- Hauschild, Axel (1)
- Hayward, Caroline (1)
- Heard-Costa, Nancy L. (1)
- Hecker, Andreas (1)
- Hedrich, Christian Michael (1)
- Heeg, Maximilian (1)
- Heid, Iris M. (1)
- Heidenreich, Olaf Torben (1)
- Heijer, Martin den (1)
- Hein, Rüdiger (1)
- Heine, Sabine (1)
- Helbich, Thomas H. (1)
- Hellige, Antje (1)
- Henes, Jörg Christoph (1)
- Hengstenberg, Christian (1)
- Henry, C (1)
- Henry, Chantal (1)
- Herbaux, C (1)
- Hernández, Isabel (1)
- Hernández-Guillamon, Mar (1)
- Herrmann, Friedrich (1)
- Heuschmann, Peter (1)
- Heywang-Köbrunner, Sylvia H. (1)
- Heß, Ursula (1)
- Hicks, Andrew A. (1)
- Hill, Matthew (1)
- Hillary, Frank G. (1)
- Hiltunen, Mikko (1)
- Hingorani, Aroon (1)
- Hinkin, Charles (1)
- Hirschhorn, Joel N. (1)
- Hofmann, J (1)
- Hohberger, Bettina (1)
- Hollingworth, Paul (1)
- Holmans, Peter (1)
- Holmes, Clive (1)
- Holzer, Ursula (1)
- Horer, Tal (1)
- Horneff, Gerd (1)
- Hoskinson, Kristen R. (1)
- Hottenga, Jouke-Jan (1)
- Houenou, Josselin (1)
- Hovingh, Kees G. (1)
- Hsieh, Patrick C. (1)
- Hubl, Daniela (1)
- Huentelman, Matthew J. (1)
- Hui, Jennie (1)
- Huikuri, Heikki (1)
- Humphries, Steve E. (1)
- Hundorfean, Gheorghe (1)
- Hung, Joseph (1)
- Hunter, David (1)
- Huppertz, Hans-Iko (1)
- Hveem, Kristian (1)
- Hyppönen, Elina (1)
- Häusler, Karl Georg (1)
- Hönig, Manfred (1)
- Høffding, Lone (1)
- Hülsmann, Brigitte (1)
- I. Berndt, Sonja (1)
- Ibrahim-Verbaas, Carla A. (1)
- Ikeda, Yukio (1)
- Ikram, M. Arfan (1)
- Illig, Thomas (1)
- Imbesi, Massimiliano (1)
- Inaba, Kenji (1)
- Ingelsson, Erik (1)
- Ingelsson, Martin (1)
- Iribarren, Carlos (1)
- Irimia, Andrei (1)
- Isometsä, Erkki T. (1)
- Ito, Manabu (1)
- Ivanov, Valentin (1)
- Ivkovic, Maja (1)
- Izraeli, S (1)
- Jablonka, Alexandra (1)
- Jackson, Anne U. (1)
- Jacobs, Kevin B. (1)
- Jager, Philip L. De (1)
- Jakoby, Donate (1)
- Jang, Dong-Kyu (1)
- Janno, Sven (1)
- Jansen, Andreas (1)
- Jarosova, M (1)
- Jarvelin, Marjo-Riitta (1)
- Jo-Pugh, Mary (1)
- Johansson, Åsa (1)
- Johnsen, Simon (1)
- Johnson, Andrew D. (1)
- Johnson, Michael R. (1)
- Johnson, Toby (1)
- Johnston, Janet A. (1)
- Jolley, Jennifer (1)
- Jones, Lesley (1)
- Jonsson, Palmi V. (1)
- Jula, Antti (1)
- Jun, Gyungah (1)
- Jurcoane, Alina (1)
- Justich, Armin (1)
- Juvonen, V (1)
- Jónsson, Ásbjörn (1)
- Kaess, Michael (1)
- Kaiser, A.-K. (1)
- Kaiser-Labusch, Petra (1)
- Kakadiya, PM (1)
- Kalwa, Hermann (1)
- Kamatani, Yoichiro (1)
- Kamboh, M. Ilyas (1)
- Kamitz, Dirk (1)
- Kamra, Komal (1)
- Kandziora, Frank (1)
- Kang, Xiaojian (1)
- Kanoni, Stavroula (1)
- Kanz, Lothar (1)
- Kanzler, Stephan (1)
- Kapczinski, Flávio (1)
- Kaplan, Robert (1)
- Kaprio, Jaakko (1)
- Karakatsoulis, Gregory N. (1)
- Kardell, Mathias (1)
- Karpe, Fredrik (1)
- Kassim, Nishad (1)
- Kate, Mahesh (1)
- Kathiresan, Sekar (1)
- Kato, So (1)
- Kauwe, John S. K. (1)
- Kazui, Seiji (1)
- Keinanen-Kiukaanniemi, Sirkka M. (1)
- Keller, Lina (1)
- Keller, Ullrich (1)
- Kellner, Nils (1)
- Kennedy, Eamonn (1)
- Kenney, Kimbra (1)
- Kenny, Graham P. (1)
- Kessing, Lars Vedel (1)
- Keřková, Barbora (1)
- Khaw, Kay-Tee (1)
- Khlif, Mohamed Salah (1)
- Khoury, Jane (1)
- Kiemeney, Lambertus Adrianus (1)
- Kike, Kaoru (1)
- Kilpeläinen, Tuomas O. (1)
- Kim, Minah (1)
- Kim, Seong Jae (1)
- Kindle, Gerhard (1)
- Kindler, Jochen (1)
- Kirchberger, Michael Constantin (1)
- Kircher, Tilo (1)
- Kirchhof, Paulus (1)
- Kirkpatrick, Andrew Wallace (1)
- Kivimaki, Mika (1)
- Klasen, Jessica (1)
- Klauw, Melanie M. van der (1)
- Kleber, Marcus E. (1)
- Klein, Ariane (1)
- Klein, Christina (1)
- Klein, Christoph (1)
- Klein, Karl Martin (1)
- Klemann, Christian (1)
- Klingebiel, Thomas (1)
- Kniep, Jonathan (1)
- Knorr, Harald (1)
- Knöchel, Christian (1)
- Knı́žková, Karolina (1)
- Kobbe, Robin (1)
- Koch, Elias Andreas Thomas (1)
- Koeleman, Bobby P. C. (1)
- Koenig, Wolfgang (1)
- Kolenova, A (1)
- Kolligs, Frank Thomas (1)
- Kolovou, Genovefa (1)
- Kolskår, Knut K. (1)
- Korvatska, Olena (1)
- Kot, Timur L. (1)
- Kovacs, Peter (1)
- Koval, Michael (1)
- Kraja, Aldi T. (1)
- Kramm, Christof M. (1)
- Krause, Karl-Heinz (1)
- Krause, Roland (1)
- Krauter, J (1)
- Krch, Denise (1)
- Kremen, William S. (1)
- Krenn, Martin (1)
- Kreuzberg, Nicole (1)
- Kreuzberg-Brenner, Nicole (1)
- Kristiansson, Kati (1)
- Krjutškov, Kaarel (1)
- Krohn, Jon P. (1)
- Krämer, Michael (1)
- Krüger, Renate (1)
- Kubetzko, S (1)
- Kuh, Diana (1)
- Kuhl, Christiane Katharina (1)
- Kuhn, Taylor (1)
- Kukull, Walter A. (1)
- Kullman, Silke (1)
- Kulozik, Andreas (1)
- Kumari, Meena (1)
- Kumari, Veena (1)
- Kunkle, Brian (1)
- Kunz, Mauricio (1)
- Kunz, Wolfram S. (1)
- Kunze, Claudia (1)
- Kustanovich, A (1)
- Kutalik, Zoltán (1)
- Kuulasmaa, Kari (1)
- Kuusisto, Johanna (1)
- Kwon, Jun Soo (1)
- König, Barbara (1)
- Kühnle, Ingrid (1)
- Laakso, Markku (1)
- Lafer, Beny (1)
- Lahey, Donna (1)
- Lakka, Timo A. (1)
- Lambert, Jean-Charles (1)
- Lamers, Beate (1)
- Lamina, Claudia (1)
- Lammert, Frank (1)
- Lancaster, Thomas M. (1)
- Landén, Mikael (1)
- Langella, Roberto (1)
- Langemeyer, Vanessa (1)
- Langenberg, Claudia (1)
- Lannfelt, Lars (1)
- Lapillone, H (1)
- Lara-Villacanas, Eusebia (1)
- Larouche, Jeremie (1)
- Larrea, Martha (1)
- Larsen, Erik R. (1)
- Larson, Eric B. (1)
- Laskawiec, Magdalena (1)
- Laskowitz, Sarah (1)
- Lassay, Lisa (1)
- Lathrop, Mark (1)
- Laufs, Ulrich (1)
- Launay, E (1)
- Launer, Lenore J. (1)
- Law-Smith, Miriam (1)
- Laws, Hans-Jürgen (1)
- Lee, DS (1)
- Lee, Jae-Yun (1)
- Lee, Jungha (1)
- Lee, Robert J. (1)
- Lehmberg, Kai (1)
- Lehtimäki, Terho (1)
- Lei, Pui-Wa (1)
- Leira, Rogelio (1)
- Leiter-Stöppke, Ulrike (1)
- Lengenfelder, Jean (1)
- Lenger, Melanie (1)
- Leppaniemi, Ari (1)
- Lerche, Holger (1)
- Letenneur, Luc (1)
- Lewitzka, Ute (1)
- Li, Guo (1)
- Li, Qi (1)
- Li, Shengxu (1)
- Liang, Liming (1)
- Licht, Rasmus W. (1)
- Liebel, Spencer W. (1)
- Liese, Johannes G. (1)
- Lin, Chiao-Feng (1)
- Lin, Heng-Fu (1)
- Lind, Lars (1)
- Linden, David (1)
- Lindgren, Cecilia M. (1)
- Lindig, U. (1)
- Lindsey, Hannah M. (1)
- Lindström, Jaana (1)
- Lionel, Anath C. (1)
- Liou-Johnson, Victoria (1)
- Lippa, Sara M. (1)
- Lippert, E (1)
- Lisencu, Eugenia C. (1)
- Lleo, Alberto (1)
- Lo Nigro, L (1)
- Locke, Adam E. (1)
- Lohse, Ansgar W. (1)
- Lokki, Marja-Liisa (1)
- Loley, Christina (1)
- Lombard, Frances (1)
- Loos, Ruth J. F. (1)
- Lopez, Oscar L. (1)
- Lopez-Jaramillo, Carlos (1)
- Lorentzon, Mattias (1)
- Love, Seth (1)
- Lovestone, Simon (1)
- Lowe, Jennifer K. (1)
- Luan, Jian'an (1)
- Lubomierski, Nikolaus (1)
- Luczynska, Elzbieta (1)
- Lund-Aho, T (1)
- Lundervold, Astri (1)
- Lunetta, Kathryn L. (1)
- Lyden, Patrick D. (1)
- Løvstad, Marianne (1)
- MacKenzie, Alan (1)
- Maccari, Maria E. (1)
- Macintyre, E (1)
- Maderer, Annett (1)
- Madsen, HO (1)
- Madsen, Helle Østergaard (1)
- Madsen, Simone Alberte Kongstad A. (1)
- Magnusson, Patrik K. E. (1)
- Mahadevan, Jayant (1)
- Mahardika, Agustine (1)
- Mahoney, William (1)
- Maier, Ron (1)
- Maier, Wolfgang (1)
- Malbrain, Manu (1)
- Manchia, Mirko (1)
- Mancuso, Michelangelo (1)
- Mangino, Massimo (1)
- Mann, Ritse M. (1)
- Mantripragada, Kiran (1)
- Marotta, Cassandra (1)
- Marquardt, Craig A. (1)
- Marques, Jose C. (1)
- Marschalek, Rolf (1)
- Marsh, Wendy (1)
- Marson, Anthony G. (1)
- Martin, Eden R. (1)
- Martin, Nicholas Gordon (1)
- Martincich, Laura (1)
- Martinez Hernandez, Juan Alberto (1)
- Martinez-Cengotitabengoa, Monica (1)
- Martiny, Klaus (1)
- Martzi, Ingo (1)
- Martí-Fàbregas, Joan (1)
- Maschio, Andrea (1)
- Mashima, Yuki (1)
- Masiakos, Peter T. (1)
- Masjosthusmann, Katja (1)
- Masotti, Luca (1)
- Mass-Malo, K (1)
- Mateo Leach, Irene (1)
- Mateo, Ignacio (1)
- Mateus, Christine (1)
- Mathieson, Iain (1)
- Mattos, Paulo (1)
- Mayeli, Ahmad (1)
- Mayer, Stephan A. (1)
- Mayeux, Richard (1)
- Mayhaus, Manuel (1)
- McArdle, Wendy L. (1)
- McCarthy, Mark I. (1)
- McCormack, Mark (1)
- McCourt, Rebecca (1)
- McDonald, Carrie R. (1)
- McGrew, Susan G. (1)
- McGuinness, Bernadette (1)
- McInnes, L. Alison (1)
- McLoughlin, Declan M. (1)
- Mead, Simon (1)
- Mecocci, Patrizia (1)
- Mederos y Schnitzler, Michael (1)
- Medina-Gomez, Carolina (1)
- Medland, Sarah E. (1)
- Meesters, Ybe (1)
- Mefire, Alain Chichom (1)
- Mehta, Ketna (1)
- Meinert, Susanne (1)
- Meissner, Marcel (1)
- Melle, Ingrid (1)
- Melotti, Rita Maria (1)
- Melzer, Tracy R. (1)
- Menendez, P (1)
- Menezes, Cristiano M. (1)
- Merchán Naranjo, Jessica (1)
- Merico, Daniele (1)
- Metspalu, Andres (1)
- Metzler, Markus (1)
- Meyer, Claus (1)
- Meza-Urzúa, Fátima (1)
- Michel, Chantal (1)
- Mielke, Gudrun (1)
- Migita, Ohsuke (1)
- Mihailov, Evelin (1)
- Min, Josine L. (1)
- Ming, Mok Yee (1)
- Minopoli, Fiorella (1)
- Mohlke, Karen L. (1)
- Mohr, Michael (1)
- Molina, Carlos (1)
- Monda, Keri L. (1)
- Montaner, Joan (1)
- Monteith, Scott (1)
- Montgomery, Grant W. (1)
- Montine, Thomas J. (1)
- Montori, Giulia (1)
- Montravers, Philippe (1)
- Moon, Byung Hoo (1)
- Moorthy, Muthukumaran (1)
- Moos, Roger von (1)
- Morbach, Henner (1)
- Morey, Rajendra A. (1)
- Morgan, Kevin (1)
- Morken, Gunnar (1)
- Morris, Andrew David (1)
- Mortier, Margarete (1)
- Mosca, Enrica (1)
- Mosley, Thomas H. (1)
- Mouga, Susana (1)
- Mozzhegorov, Anton A. (1)
- Muehlbauer, Eric J. (1)
- Mullerpatan, Rajani (1)
- Mulukutla, Raghava D. (1)
- Munoz, Rodrigo (1)
- Munroe, Patricia B. (1)
- Murai, Yasuo (1)
- Mwangi, Benson (1)
- Myall, Daniel J. (1)
- Myers, Amanda J. (1)
- Mythri, Starlin V. (1)
- Mägi, Reedik (1)
- März, Winfried (1)
- Möhler, Markus (1)
- Möricke, A (1)
- Møller, Rikke S. (1)
- Müglich, Carmen (1)
- Müller, Anna H. (1)
- Müller, Christiane (1)
- Müller, Ingo (1)
- Müller, Thomas G. (1)
- Müller-Nurasyid, Martina (1)
- Müller-Schimpfle, Markus (1)
- Münstermann, Esther (1)
- Nabavi, Darius Günther (1)
- Nacef, Fethi (1)
- Nacmias, Benedetta (1)
- Nadella, Ravi K. (1)
- Naidoo, Noel (1)
- Naj, Adam C. (1)
- Nakanotani, Takako (1)
- Nalls, Michael A. (1)
- Napolitano, Lena (1)
- Narisu, Narisu (1)
- Naumann-Bartsch, Nora (1)
- Navis, Gerjan (1)
- Nenadić, Igor (1)
- Neubert, Jennifer (1)
- Newsome, Mary R. (1)
- Nicholson, George (1)
- Niehues, Tim (1)
- Nielsen, René Ernst (1)
- Nies, Anne T, (1)
- Nikanorova, Marina (1)
- Njølstad, Inger (1)
- Nolte, Ilja M. (1)
- Noor, Abdul (1)
- Nordin, Margareta (1)
- North, Kari E. (1)
- Nunes, Abraham (1)
- O'Connell, Jeffrey R. (1)
- O'Donovan, Claire (1)
- Oertel, Viola (1)
- Oertel-Knöchel, Viola (1)
- Offermanns, Stefan (1)
- Oh, SH (1)
- Ohlsson, Claes (1)
- Oishi, Makoto (1)
- Okada, Yasushi (1)
- Oliveira, Bárbara (1)
- Ollinger, John (1)
- Olma, Manuel C. (1)
- Olsen, Alexander (1)
- Omrani, Adel (1)
- Ong, Ken K. (1)
- Oommen, Prasad Thomas (1)
- Oostra, Ben A. (1)
- Ordoñez, Carlos A. (1)
- Ormandi, Katalin (1)
- Ortiz Garcı́a de la Foz, Victor (1)
- Osher, Yamima (1)
- Ouali, Uta (1)
- Ozmen, Mustafa (1)
- O’Brien, Terence J. (1)
- Pak, Oleg (1)
- Palmer, Colin N. A. (1)
- Palmer, Lyle J. (1)
- Panizza, Pietro (1)
- Pantovic-Stefanovic, Maja (1)
- Panza, Francesco (1)
- Panzer-Grümayer, Renate (1)
- Pardoe, Heath (1)
- Parent, Marise (1)
- Pariwatcharakul, Pornjira (1)
- Park, TS (1)
- Parry, Neil (1)
- Pasquier, Florence (1)
- Passmore, Peter (1)
- Pastor, Pau (1)
- Pechlivanis, Sonali (1)
- Pedersen, Nancy L. (1)
- Pediconi, Federica (1)
- Peitz, Joachim (1)
- Peitzman, Andrew B. (1)
- Pellecchia, Giovanna (1)
- Penninx, Brenda W. J. H. (1)
- Pereira, Bruno M. (1)
- Pereira, Paulo (1)
- Perola, Markus (1)
- Perry, William (1)
- Person, Thomas (1)
- Peters, Annette (1)
- Petite, Joanne (1)
- Petzold, Anne (1)
- Pfeilschifter, Waltraud (1)
- Pfennig, Andrea (1)
- Pica Ruiz, Yolanda (1)
- Piccirillo, Michael (1)
- Pichler, Sabrina (1)
- Pijnappel, Ruud M. (1)
- Pilhatsch, Maximilian (1)
- Pilorge, Marion (1)
- Pilotto, Alberto (1)
- Pinker, Katja (1)
- Pinna, Marco (1)
- Piras, Fabrizio (1)
- Piras, Federica (1)
- Pomarol-Clotet, Edith (1)
- Pombo de Oliveira, M (1)
- Pompili, Maurizio (1)
- Porter, Richard (1)
- Powell, John F. (1)
- Power, Chris (1)
- Pramstaller, Peter P. (1)
- Prasad, Aparna (1)
- Prats-Sánchez, Luis (1)
- Price, Jackie F. (1)
- Proitsi, Petra (1)
- Prokopenko, Inga (1)
- Province, Michael A. (1)
- Prvulovic, David (1)
- Psaty, Bruce M. (1)
- Pätzold, Sylvie (1)
- Qi, Lu (1)
- Quiroz, Danilo (1)
- Raab, Peter (1)
- Rabelo-da-Ponte, Francisco Diego (1)
- Rack-Hoch, Anita (1)
- Rahimi, Farnaz (1)
- Raitakari, Olli (1)
- Rajasekaran, Shanmuganathan (1)
- Ramesar, Raj (1)
- Ramirez, Alfredo (1)
- Randall, Joshua C. (1)
- Rasgon, Natalie (1)
- Ratta-apha, Woraphat (1)
- Ratzenhofer, Michaela (1)
- Rauramaa, Rainer (1)
- Razek, Tarek (1)
- Razquin, Cristina (1)
- Redahan, Maria (1)
- Reddy, M. S. (1)
- Rehnberg, Emil (1)
- Reif, Andreas (1)
- Reinhardt, Lydia (1)
- Reininghaus, Eva Z. (1)
- Reinke, Britta (1)
- Reitz, Christiane (1)
- Renneville, A (1)
- Renshaw, Katy (1)
- Repple, Jonathan (1)
- Reva, Viktor (1)
- Rice, John P. (1)
- Richard, Geneviève (1)
- Richards, Alexander (1)
- Richards, Jenny Gringer (1)
- Rickaby, Jessica (1)
- Ridker, Paul M. (1)
- Rieber, Nikolaus (1)
- Riemenschneider, Matthias (1)
- Ripatti, Samuli (1)
- Rissanen, Tarja (1)
- Ritchie, Karen (1)
- Ritter, Philipp (1)
- Ritterbusch, Henrike (1)
- Rivadeneira, Fernando (1)
- Rivolta, Carlo (1)
- Rizoli, Sandro (1)
- Robert, Caroline (1)
- Roberts, Derek (1)
- Roberts, Lisa (1)
- Rockstroh, Jürgen (1)
- Rodriguez, Jonathan (1)
- Rodriguez, Mabel (1)
- Rodríguez-Luna, David (1)
- Roesler, Joachim (1)
- Rogaeva, Ekaterina (1)
- Rootes-Murdy, Kelly (1)
- Rosand, Jonathan (1)
- Rose, Lynda M. (1)
- Rotaru, Natalia (1)
- Rotter, Jerome I. (1)
- Rowland, Jared (1)
- Rubinsztein, David C. (1)
- Rudan, Igor (1)
- Ruiz, Agustin (1)
- Rujescu, Dan (1)
- Ruosi, Carlo (1)
- Rusch, Stephan (1)
- Russo, Giancarlo (1)
- Ryan, Nicholas P. (1)
- Rybakowski, Janusz K. (1)
- Rösen-Wolff, Angela (1)
- Röther, Joachim (1)
- Saaristo, Timo E. (1)
- Sager, Hendrik (1)
- Saguatti, Gianni (1)
- Salomaa, Veikko (1)
- Salt, Jeff (1)
- Salvador, Raymond (1)
- Salvetti, Francesco (1)
- Samani, Nilesh J. (1)
- Sambrook, Jennifer G. (1)
- Sanchez Garcia, Florentino (1)
- Sander, Josemir W. (1)
- Sander, Thomas (1)
- Sanders, Anne-Marthe (1)
- Sansom, Katherine (1)
- Saramies, Jouko (1)
- Sardanelli, Francesco (1)
- Sathyaputri, Leela (1)
- Sato, Daisuke (1)
- Satzger, Imke (1)
- Sauvigny, Christiane (1)
- Scarpini, Elio (1)
- Schadmand-Fischer, Simin (1)
- Schauer, Uwe (1)
- Scheibenbogen, Carmen (1)
- Scheible, Raphael (1)
- Schell, Beatrice (1)
- Scherag, André (1)
- Schermuly, Ralph T. (1)
- Schimanski, Carl C. (1)
- Schlaak, Max (1)
- Schlaak, Max Simon (1)
- Schlaeppi, Marc (1)
- Schlessinger, David (1)
- Schlitt, Sabine (1)
- Schmalzing, Marc (1)
- Schmidt, André (1)
- Schmidt, Harald H. H. W. (1)
- Schmidt, Helena (1)
- Schmidt, Nadine (1)
- Schmidt, Reinhold (1)
- Schmidt, Reinhold E. (1)
- Schneider, Dominik T. (1)
- Schrappe, M (1)
- Schreiber, Stefan (1)
- Schubert, Ralf (1)
- Schuler, Gerold (1)
- Schulz, Ansgar (1)
- Schulz, Claudia (1)
- Schulz, Herbert (1)
- Schunkert, Heribert (1)
- Schurig, Johannes (1)
- Schwab, Matthias (1)
- Schwaneck, Eva C. (1)
- Schwarz, Klaus (1)
- Schwarz, Peter E. H. (1)
- Schwarze-Zander, Carolynne (1)
- Schweigerer, Lothar (1)
- Schäfer, BW (1)
- Schäffeler, Elke (1)
- Schönberger, Stefan (1)
- Schürmann, Gesine (1)
- Schütz, Matthias (1)
- Scippa, Ângela M. (1)
- Sedék, L (1)
- Seeger, Werner (1)
- Segurado, Ricardo (1)
- Seifert, Volker (1)
- Selim, Magdy (1)
- Sella, Tamar (1)
- Senman, Lili (1)
- Sequeira, Ana F. (1)
- Seshadri, Sudha (1)
- Severus, Emanuel (1)
- Seyedsaadat, Seyed Mohammad (1)
- Shah, Ajay M. (1)
- Shai, Sonu (1)
- Shetty, Ajoy Prasad (1)
- Shi, Jianxin (1)
- Shields, Denis C. (1)
- Shuldiner, Alan R. (1)
- Shungin, Dmitry (1)
- Siciliano, Gabriele (1)
- Sills, Graeme J. (1)
- Silva, ML (1)
- Simhandl, Christian (1)
- Simone, Belinda De (1)
- Sims, Rebecca (1)
- Sinisalo, Juha (1)
- Sisodiya, Sanjay M. (1)
- Sleegers, Kristel (1)
- Slobodníková, Jana (1)
- Smith, Albert V. (1)
- Smith, Albert Vernon (1)
- Smith, Daniel (1)
- Smith, José (1)
- Snieder, Harold (1)
- Soares, Jair C. (1)
- Sobik, Bettina (1)
- Soetedjo, Veronika (1)
- Sogkas, Georgios (1)
- Soininen, Hilkka (1)
- Solfrizzi, Vincenzo (1)
- Sollinger, Franz (1)
- Sorbi, Sandro (1)
- Soreide, Kjetil (1)
- Spalleta, Gianfranco (1)
- Spalletta, Gianfranco (1)
- Specker, Christof (1)
- Speckmann, Carsten (1)
- Spector, Tim D. (1)
- Speliotes, Elizabeth K. (1)
- Srivastava, Sudhir K. (1)
- St George-Hyslop, Peter (1)
- Stackhouse Jr., Paul W. (1)
- Stanulla, M (1)
- Stasenko, Alena (1)
- Staykov, Dimitre (1)
- Stefansson, Kari (1)
- Stege, Henner Maximilian (1)
- Stein, Dan J. (1)
- Stein, Frederike (1)
- Steiner, Thorsten (1)
- Steinmann, Sandra (1)
- Steinthorsdottir, Valgerdur (1)
- Stiefel, Martina (1)
- Stilwell, Kellen (1)
- Stirrups, Kathleen (1)
- Storch, Ursula (1)
- Storchak, Helena (1)
- Strachan, David P. (1)
- Straube, Benjamin (1)
- Strawbridge, Christina (1)
- Strawbridge, Rona J. (1)
- Strehl, S (1)
- Strejilevich, Sergio (1)
- Striano, Pasquale (1)
- Stäblein, Michael (1)
- Su, Kuan-Pin (1)
- Subramaniam, Mythily (1)
- Sulaiman, Ahmad Hatim (1)
- Sullivan, William (1)
- Suominen, Kirsi (1)
- Surakka, Ida (1)
- Sutton, R (1)
- Swift, Amy J. (1)
- Sydykov, Akylbek (1)
- Szczepański, T (1)
- Talk, Maret (1)
- Talmant, P (1)
- Tamai, Koji (1)
- Tanra, Andi J. (1)
- Tansey, Katherine (1)
- Tansey, Katherine E. (1)
- Taourel, Patrice (1)
- Tate, David F. (1)
- Tatebayashi, Yoshitaka (1)
- Tauber, Maïté (1)
- Te Kronnie, G (1)
- Teder-Laving, Maris (1)
- Teh, Wen Lin (1)
- Teixeira, MR (1)
- Teli, Marco G. A. (1)
- Tenbrock, Klaus (1)
- Teumer, Alexander (1)
- Thames, April (1)
- Thiruvahindrapduram, Bhooma (1)
- Thiruvahindrapuram, Bhooma (1)
- Thomalla, Götz (1)
- Thomas, Charlene (1)
- Thomas-Odenthal, Florian (1)
- Thomopoulos, Sophia I. (1)
- Thompson, Paul M. (1)
- Thorand, Barbara (1)
- Thorleifsson, Gudmar (1)
- Thornton-Wells, Tricia A. (1)
- Thorsteinsdottir, Unnur (1)
- Tietsch, Nadine (1)
- Todd, Stephen (1)
- Tolonen, Matti (1)
- Tomasoni, Matteo (1)
- Tondeur, S (1)
- Tondo, Leonardo (1)
- Tone, Erin (1)
- Tony, Hans-Peter (1)
- Torrent, Carla (1)
- Torres, Ivan (1)
- Toyoda, Kazunori (1)
- Trakhtenbrot, L (1)
- Trefzer, Uwe (1)
- Tremoli, Elena (1)
- Trimboli, Rubina Manuela (1)
- Trka, J (1)
- Trojan, Jörg (1)
- Troyanskaya, Maya (1)
- Tsaur, G (1)
- Tsolaki, Magda (1)
- Tsuang, Debby W. (1)
- Tucci, Carlos (1)
- Tuinstra, Daniel (1)
- Tuomilehto, Jaakko (1)
- Turner, Jessica A. (1)
- Tyrer, Jonathan (1)
- Tzourio, Christophe (1)
- Tönjes, Anke (1)
- Tütüncü, Serdar (1)
- Uchida, Takahito (1)
- Ugurel, Selma (1)
- Uitterlinden, André G. (1)
- Ulrichsen, Kristine M. (1)
- Umpierrez, Guillermo (1)
- Uusitupa, Matti (1)
- Vaaler, Arne E. (1)
- Vadlamani, Shashank (1)
- Valetti, Tino M. (1)
- Valladares, Otto (1)
- Vardarajan, Badri N. (1)
- Vaubel, Julia (1)
- Vedantam, Sailaja (1)
- Vedernikov, Alexey (1)
- Veeh, Julia (1)
- Veit, Florian (1)
- Vejborg, Ilse (1)
- Veltkamp, Roland (1)
- Venkatasubramanian, Chitra (1)
- Venn, NC (1)
- Viemann, Dorothee (1)
- Vieta, Eduard (1)
- Vilella, Elisabet (1)
- Vinnemeier-Laubenthal, Elisabeth (1)
- Virtamo, Jarmo (1)
- Viswanath, Biju (1)
- Vivash, Lucy (1)
- Vliet-Ostaptchouk, Jana V. van (1)
- Vlok, Adriaan (1)
- Volbers, Bastian (1)
- Vormoor, J (1)
- Vorstman, JAS (1)
- Voskens, Caroline J. (1)
- Vourtsis, Athina (1)
- Vronskaya, Maria (1)
- Völzke, Henry (1)
- Wachtlin, Daniel (1)
- Wadhwa, Sanjay (1)
- Wagner, Norbert (1)
- Waite, Lindsay L. (1)
- Walker, William C. (1)
- Wallon, David (1)
- Wang, Jeffrey C. (1)
- Wang, Li-San (1)
- Wang, Xia (1)
- Wang, Zhaoming (1)
- Wang, Zhouzhi (1)
- Wang, Zhuozhi (1)
- Wareham, Nicholas J. (1)
- Warnatz, Klaus (1)
- Wasmuth, Jan-Christian (1)
- Weber, Dieter (1)
- Weber, Yvonne G. (1)
- Weckhuysen, Sarah (1)
- Weder, Patrik (1)
- Wehner, S (1)
- Weichenthal, Michael (1)
- Weiß, Michael (1)
- Weißmann, Norbert (1)
- Werden, Emilio (1)
- Wessely, Anja (1)
- Westkemper, Marco (1)
- Westlye, Lars T. (1)
- White, Kathy (1)
- Whybrow, Peter C. (1)
- Wichmann, Heinz Erich (1)
- Wild, Krista (1)
- Wilde, Elisabeth A. (1)
- Wilhelm, Tabea (1)
- Williams, Julie (1)
- Wilsgaard, Tom (1)
- Wilson, James F. (1)
- Winkelmann, Bernhard R. (1)
- Winkler, Thomas W. (1)
- Wittke, Kirsten (1)
- Wittkowski, Helmut (1)
- Wolking, Stefan (1)
- Wong, Andrew (1)
- Wood, Andrew R. (1)
- Workalemahu, Tsegaselassie (1)
- Worthmann, Hans (1)
- Wroblewski, Adrian (1)
- Wu, Mon-Ju (1)
- Wylie, Glenn R. (1)
- Wölke, Sandra (1)
- Wörns, Marcus Alexander (1)
- Xu, Xiao (1)
- Yalcinkaya, Oguz Kaan (1)
- Yamamoto, Haruko (1)
- Yang, Jian (1)
- Yao, Xiaoying (1)
- Yarnell, John W. G. (1)
- Yatham, Lakshmi N. (1)
- Yoldi-Negrete, Maria (1)
- Young, Allan H. (1)
- Younkin, Steven G. (1)
- Yu, Lei (1)
- Yuan, Kuo-Ching (1)
- Zara, Federico J. (1)
- Zazulia, Allyson R. (1)
- Zelenika, Diana (1)
- Zeuner, Rainald (1)
- Zgueb, Yosra (1)
- Zhao, Jing Hua (1)
- Ziai, Wendy C. (1)
- Zielen, Stefan (1)
- Ziller, Fabian (1)
- Zillikens, M. Carola (1)
- Ziman, Robert (1)
- Zimmer, Lisa (1)
- Zimmermann, Antje (1)
- Zimmermann, S. (1)
- Zimprich, Fritz (1)
- Zou, Fanggeng (1)
- Zuna, J (1)
- Zunta-Soares, Giovana B. (1)
- Zwaan, CM (1)
- van Dongen, JJ (1)
- van den Heuvel-Eibrink, MM (1)
- van der Velden, VH (1)
- zur Stadt, U (1)
- Álvarez, Marina (1)
- Álvarez-Sabín, José (1)
- Ülzen, Anett (1)
- Španiel, Filip (1)
Year of publication
Document Type
- Article (26)
- Conference Proceeding (1)
- Preprint (1)
Language
- English (28)
Has Fulltext
- yes (28)
Is part of the Bibliography
- no (28)
Keywords
- ALL (1)
- AML (1)
- Abdominal infections (1)
- Acute calcolous cholecystitis (1)
- Advanced biliary tract cancer (1)
- Antibiotic (1)
- BTC (1)
- Biliary tree stones (1)
- Biological (1)
- Biomarker (1)
Institute
- Medizin (28) (remove)
Al-Shahi Salman, Rustam ; Frantzias, Joseph ; Lee, Robert J. ; Lyden, Patrick D. ; Battey, Thomas W. K. ; Ayres, Alison M. ; Goldstein, Joshua Norkin ; Mayer, Stephan A. ; Steiner, Thorsten ; Wang, Xia ; Arima, Hisatomi ; Hasegawa, Hitoshi ; Oishi, Makoto ; Godoy, Daniel Agustín ; Masotti, Luca ; Dowlatshahi, Dar ; Rodríguez-Luna, David ; Molina, Carlos ; Jang, Dong-Kyu ; Davalos, Antonio ; Castillo, José ; Yao, Xiaoying ; Claassen, Jan ; Volbers, Bastian ; Kazui, Seiji ; Okada, Yasushi ; Fujimoto, Shigeru ; Toyoda, Kazunori ; Li, Qi ; Khoury, Jane ; Delgado, Pilar ; Álvarez-Sabín, José ; Hernández-Guillamon, Mar ; Prats-Sánchez, Luis ; Cai, Chunyan ; Kate, Mahesh ; McCourt, Rebecca ; Venkatasubramanian, Chitra ; Diringer, Michael N. ; Ikeda, Yukio ; Worthmann, Hans ; Ziai, Wendy C. ; D’Esterre, Christopher D. ; Aviv, Richard I. ; Raab, Peter ; Murai, Yasuo ; Zazulia, Allyson R. ; Butcher, Kenneth ; Seyedsaadat, Seyed Mohammad ; Grotta, James C. ; Martí-Fàbregas, Joan ; Montaner, Joan ; Broderick, Joseph ; Yamamoto, Haruko ; Staykov, Dimitre ; Connolly, Edward Sander ; Selim, Magdy ; Leira, Rogelio ; Moon, Byung Hoo ; Demchuk, Andrew M. ; Di Napoli, Mario ; Fujii, Yukihiko ; Anderson, Craig S. ; Rosand, Jonathan
Background: Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography.
Methods: In a systematic review of OVID MEDLINE—with additional hand-searching of relevant studies' bibliographies— from Jan 1, 1970, to Dec 31, 2015, we identified observational cohorts and randomised trials with repeat scanning protocols that included at least ten patients with acute intracerebral haemorrhage. We sought individual patient-level data from corresponding authors for patients aged 18 years or older with data available from brain imaging initially done 0·5–24 h and repeated fewer than 6 days after symptom onset, who had baseline intracerebral haemorrhage volume of less than 150 mL, and did not undergo acute treatment that might reduce intracerebral haemorrhage volume. We estimated the absolute risk and predictors of the primary outcome of intracerebral haemorrhage growth (defined as >6 mL increase in intracerebral haemorrhage volume on repeat imaging) using multivariable logistic regression models in development and validation cohorts in four subgroups of patients, using a hierarchical approach: patients not taking anticoagulant therapy at intracerebral haemorrhage onset (who constituted the largest subgroup), patients taking anticoagulant therapy at intracerebral haemorrhage onset, patients from cohorts that included at least some patients taking anticoagulant therapy at intracerebral haemorrhage onset, and patients for whom both information about anticoagulant therapy at intracerebral haemorrhage onset and spot sign on acute CT angiography were known.
Findings: Of 4191 studies identified, 77 were eligible for inclusion. Overall, 36 (47%) cohorts provided data on 5435 eligible patients. 5076 of these patients were not taking anticoagulant therapy at symptom onset (median age 67 years, IQR 56–76), of whom 1009 (20%) had intracerebral haemorrhage growth. Multivariable models of patients with data on antiplatelet therapy use, data on anticoagulant therapy use, and assessment of CT angiography spot sign at symptom onset showed that time from symptom onset to baseline imaging (odds ratio 0·50, 95% CI 0·36–0·70; p<0·0001), intracerebral haemorrhage volume on baseline imaging (7·18, 4·46–11·60; p<0·0001), antiplatelet use (1·68, 1·06–2·66; p=0·026), and anticoagulant use (3·48, 1·96–6·16; p<0·0001) were independent predictors of intracerebral haemorrhage growth (C-index 0·78, 95% CI 0·75–0·82). Addition of CT angiography spot sign (odds ratio 4·46, 95% CI 2·95–6·75; p<0·0001) to the model increased the C-index by 0·05 (95% CI 0·03–0·07).
Interpretation: In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination. These models could inform the location and frequency of observations on patients in clinical practice, explain treatment effects in prior randomised trials, and guide the design of future trials.
Funding: UK Medical Research Council and British Heart Foundation.
Anney, Richard ; Klei, Lambertus ; Pinto, Dalila ; Almeida, Joana ; Bacchelli, Elena ; Baird, Gillian ; Bolshakova, Nadia ; Bölte, Sven ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Brian, Jessica ; Casey, Jillian ; Conroy, Judith ; Correia, Catarina ; Corsello, Christina ; Crawford, Emily L. ; Jonge, Maretha de ; Delorme, Richard ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Fombonne, Eric ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Green, Andrew ; Green, Jonathan ; Guter, Stephen J. ; Heron, Elizabeth A. ; Holt, Richard ; Howe, Jennifer L. ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Jacob, Suma ; Kenny, Graham P. ; Kim, Cecilia ; Kolevzon, Alexander ; Kustanovich, Vlad ; Lajonchere, Clara M. ; Lamb, Janine A. ; Law-Smith, Miriam ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Liu, Xiao-Qing ; Lombard, Frances ; Lord, Catherine ; Lotspeich, Linda ; Lotspeich, Linda ; Lund, Sabata C. ; Magalhães, Tiago R. ; Mantoulan, Carine ; McDougle, Christopher J. ; Melhem, Nadine M. ; Merikangas, Alison ; Minshew, Nancy J. ; Mirza, Ghazala K. ; Munson, Jeff ; Noakes, Carolyn ; Nygren, Gudrun ; Papanikolaou, Katerina ; Pagnamenta, Alistair T. ; Parrini, Barbara ; Paton, Tara ; Paton, Tara ; Pickles, Andrew ; Posey, David J. ; Poustka, Fritz ; Ragoussis, Jiannis ; Regan, Regina ; Roberts, Wendy ; Roeder, Kathryn ; Roge, Bernadette ; Rutter, Michael L. ; Schlitt, Sabine ; Shah, Naisha ; Sheffield, Val C. ; Soorya, Latha ; Sousa, Inês ; Stoppioni, Vera ; Sykes, Nuala ; Tancredi, Raffaella ; Thompson, Ann P. ; Thomson, Susanne ; Tryfon, Ana ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Vorstman, JAS ; Wallace, Simon ; Wing, Kirsty ; Wittemeyer, Kerstin ; Wood, Shawn ; Zurawiecki, Danielle ; Zwaigenbaum, Lonnie ; Bailey, Anthony J. ; Battaglia, Agatino ; Cantor, Rita M. ; Coon, Hilary ; Cuccaro, Michael L. ; Dawson, Geraldine ; Ennis, Sean ; Freitag, Christine M. ; Geschwind, Daniel H. ; Haines, Jonathan L. ; Klauck, Sabine M. ; McMahon, William M. ; Maestrini, Elena ; Miller, Judith ; Monaco, Anthony P. ; Nelson, Stanley F. ; Nurnberger, John I. ; Oliveira, Guiomar ; Parr, Jeremy R. ; Pericak-Vance, Margaret Ann ; Piven, Joseph ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Vicente, Astrid M. ; Wassink, Thomas H. ; Wijsman, Ellen M. ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cook, Edwin H. ; Gallagher, Louise ; Gill, Michael ; Hallmayer, Joachim ; Paterson, Andrew D. ; Sutcliffe, James S. ; Szatmari, Peter ; Vieland, Veronica J. ; Hakonarson, Hakon ; Devlin, Bernie
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
Anney, Richard ; Klei, Lambertus ; Pinto, Dalila ; Regan, Regina ; Conroy, Judith ; Magalhães, Tiago R. ; Correia, Catarina ; Abrahams, Brett S. ; Sykes, Nuala ; Pagnamenta, Alistair T. ; Almeida, Joana ; Bacchelli, Elena ; Bailey, Anthony J. ; Baird, Gillian ; Battaglia, Agatino ; Berney, Tom ; Bolshakova, Nadia ; Bölte, Sven ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Brian, Jessica ; Carson, Andrew R. ; Casallo, Guillermo ; Casey, Jillian ; Chu, Su H. ; Cochrane, Lynne ; Corsello, Christina ; Crawford, Emily L. ; Crossett, Andrew ; Dawson, Geraldine ; Jonge, Maretha de ; Delorme, Richard ; Drmic, Irene ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Fombonne, Eric ; Freitag, Christine M. ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Goldberg, Jeremy ; Green, Jonathan ; Guter, Stephen J. ; Hakonarson, Hakon ; Heron, Elizabeth A. ; Hill, Matthew ; Holt, Richard ; Howe, Jennifer L. ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Kim, Cecilia ; Klauck, Sabine M. ; Kolevzon, Alexander ; Korvatska, Olena ; Kustanovich, Vlad ; Lajonchere, Clara M. ; Lamb, Janine A. ; Laskawiec, Magdalena ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Lionel, Anath C. ; Liu, Xiao-Qing ; Lord, Catherine ; Lotspeich, Linda ; Lund, Sabata C. ; Maestrini, Elena ; Mahoney, William ; Mantoulan, Carine ; Marshall, Christian R. ; McConachie, Helen ; McDougle, Christopher J. ; McGrath, Jane ; McMahon, William M. ; Melhem, Nadine M. ; Merikangas, Alison ; Migita, Ohsuke ; Minshew, Nancy J. ; Mirza, Ghazala K. ; Munson, Jeff ; Nelson, Stanley F. ; Noakes, Carolyn ; Noor, Abdul ; Nygren, Gudrun ; Oliveira, Guiomar ; Papanikolaou, Katerina ; Parr, Jeremy R. ; Parrini, Barbara ; Paton, Tara ; Pickles, Andrew ; Piven, Joseph ; Posey, David J. ; Poustka, Annemarie ; Poustka, Fritz ; Prasad, Aparna ; Ragoussis, Jiannis ; Renshaw, Katy ; Rickaby, Jessica ; Roberts, Wendy ; Roeder, Kathryn ; Roge, Bernadette ; Rutter, Michael L. ; Bierut, Laura Jean ; Rice, John P. ; Salt, Jeff ; Sansom, Katherine ; Sato, Daisuke ; Segurado, Ricardo ; Senman, Lili ; Shah, Naisha ; Sheffield, Val C. ; Soorya, Latha ; Sousa, Inês ; Stoppioni, Vera ; Strawbridge, Christina ; Tancredi, Raffaella ; Tansey, Katherine ; Thiruvahindrapduram, Bhooma ; Thompson, Ann P. ; Thomson, Susanne ; Tryfon, Ana ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Wallace, Simon ; Wang, Kai ; Wang, Zhouzhi ; Wassink, Thomas H. ; Wing, Kirsty ; Wittemeyer, Kerstin ; Wood, Shawn ; Yaspan, Brian L. ; Zurawiecki, Danielle ; Zwaigenbaum, Lonnie ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cantor, Rita M. ; Cook, Edwin H. ; Coon, Hilary ; Cuccaro, Michael L. ; Gallagher, Louise ; Geschwind, Daniel H. ; Gill, Michael ; Haines, Jonathan L. ; Miller, Judith ; Monaco, Anthony P. ; Nurnberger, John I. ; Paterson, Andrew D. ; Pericak-Vance, Margaret Ann ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Sutcliffe, James S. ; Szatmari, Peter ; Vicente, Astrid M. ; Vieland, Veronica J. ; Wijsman, Ellen M. ; Devlin, Bernie ; Ennis, Sean ; Hallmayer, Joachim
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
Ansaloni, Luca ; Pisano, Michele ; Coccolini, Federico ; Peitzmann, Andrew B. ; Fingerhut, Abe ; Catena, Fausto ; Agresta, Ferdinando ; Allegri, Andrea ; Bailey, Ian ; Balogh, Zsolt J. ; Bendinelli, Cino ; Biffl, Walter ; Bonavina, Luigi ; Borzellino, Giuseppe ; Brunetti, Francesco ; Burlew, Clay Cothren ; Camapanelli, Giampiero ; Campanile, Fabio Cesare ; Ceresoli, Marco ; Chiara, Osvaldo ; Civil, Ian ; Coimbra, Raul ; De Moya, Marc ; Di Saverio, Salomone ; Fraga, Gustavo Pereira ; Gupta, Sanjay ; Kashuk, Jeffry L. ; Kelly, Michael Denis ; Khokha, Vladimir ; Jeekel, Hans ; Latifi, Rifat ; Leppäniemi, Ari Kalevi ; Maier, Ronald V. ; Marzi, Ingo ; Moore, Frederick Alan ; Piazzalunga, Dario ; Sakakushev, Boris ; Sartelli, Massimo ; Scalea, Thomas ; Stahel, Philip F. ; Taviloglu, Korhan ; Tugnoli, Gregorio ; Uranüs, Selman ; Velmahos, George C. ; Wani, Imtiaz ; Weber, Dieter G. ; Viale, Pierluigi ; Sugrue, Michael ; Ivatury, Rao ; Kluger, Yoram ; Gurusamy, Kurinchi S. ; Moore, Ernest E.
Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of “high risk” patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.
Ansaloni, Luca ; Pisano, Michele ; Coccolini, Federico ; Peitzmann, Andrew B. ; Fingerhut, Abe ; Catena, Fausto ; Agresta, Ferdinando ; Allegri, Andrea ; Bailey, Ian ; Balogh, Zsolt J. ; Bendinelli, Cino ; Biffl, Walter ; Bonavina, Luigi ; Borzellino, Giuseppe ; Brunetti, Francesco ; Burlew, Clay Cothren ; Camapanelli, Giampiero ; Campanile, Fabio Cesare ; Ceresoli, Marco ; Chiara, Osvaldo ; Civil, Ian ; Coimbra, Raul ; De Moya, Marc ; Di Saverio, Salomone ; Fraga, Gustavo Pereira ; Gupta, Sanjay ; Kashuk, Jeffry L. ; Kelly, Michael Denis ; Khokha, Vladimir ; Jeekel, Hans ; Latifi, Rifat ; Leppäniemi, Ari Kalevi ; Maier, Ronald V. ; Marzi, Ingo ; Moore, Frederick Alan ; Piazzalunga, Dario ; Sakakushev, Boris ; Sartelli, Massimo ; Scalea, Thomas ; Stahel, Philip F. ; Taviloglu, Korhan ; Tugnoli, Gregorio ; Uranüs, Selman ; Velmahos, George C. ; Wani, Imtiaz ; Weber, Dieter G. ; Viale, Pierluigi ; Sugrue, Michael ; Ivatury, Rao ; Kluger, Yoram ; Gurusamy, Kurinchi S. ; Moore, Ernest E.
Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; Agaoglu, Esen ; Altınbaş, Kürşat ; Andreassen, Ole A. ; Angelopoulos, Elias ; Ardau, Raffaella ; Arrua Vares, Edgar ; Aydin, Memduha ; Ayhan, Yavuz ; Baethge, Christopher Jan ; Bauer, Rita ; Baune, Bernhard T. ; Balaban, Ceylan ; Becerra-Palars, Claudia ; Behere, Aniruddh P. ; Behere, Prakash B. ; Belete, Habte ; Belete, Tilahun ; Belizario, Gabriel Okawa ; Bellivier, Frank ; Belmaker, Robert H. ; Benedetti, Francesco ; Berk, Michael ; Bersudsky, Yuly ; Bicakci, Şule ; Birabwa-Oketcho, Harriet ; Bjella, Thomas D. ; Brady, Conan ; Cabrera, Jorge ; Cappucciati, Marco ; Castro, Angela Marianne Paredes ; Chen, Wei-Ling ; Cheung, Eric Y. Wo ; Chiesa, Silvia ; Crowe, Marie ; Cuomo, Alessandro ; Dallaspezia, Sara ; Del Zompo, Maria ; Desai, Pratikkumar ; Dodd, Seetal ; Donix, Markus ; Etain, Bruno ; Fagiolini, Andrea ; Fellendorf, Frederike Tabea ; Ferensztajn-Rochowiak, Ewa ; Fiedorowicz, Jess G. ; Fountoulakis, Kostas N. ; Frye, Mark A. ; Geoffroy, Pierre A. ; Gonzalez-Pinto, Ana ; Gottlieb, John F. ; Grof, Paul ; Haarman, Bartholomeus C. M. ; Harima, Hirohiko ; Hasse-Sousa, Mathias ; Henry, Chantal ; Høffding, Lone ; Houenou, Josselin ; Imbesi, Massimiliano ; Isometsä, Erkki T. ; Ivkovic, Maja ; Janno, Sven ; Johnsen, Simon ; Kapczinski, Flávio ; Karakatsoulis, Gregory N. ; Kardell, Mathias ; Kessing, Lars Vedel ; Kim, Seong Jae ; König, Barbara ; Kot, Timur L. ; Koval, Michael ; Kunz, Mauricio ; Lafer, Beny ; Landén, Mikael ; Larsen, Erik R. ; Lenger, Melanie ; Lewitzka, Ute ; Licht, Rasmus W. ; Lopez-Jaramillo, Carlos ; MacKenzie, Alan ; Madsen, Helle Østergaard ; Madsen, Simone Alberte Kongstad A. ; Mahadevan, Jayant ; Mahardika, Agustine ; Manchia, Mirko ; Marsh, Wendy ; Martinez-Cengotitabengoa, Monica ; Martiny, Klaus ; Mashima, Yuki ; McLoughlin, Declan M. ; Meesters, Ybe ; Melle, Ingrid ; Meza-Urzúa, Fátima ; Ming, Mok Yee ; Monteith, Scott ; Moorthy, Muthukumaran ; Morken, Gunnar ; Mosca, Enrica ; Mozzhegorov, Anton A. ; Munoz, Rodrigo ; Mythri, Starlin V. ; Nacef, Fethi ; Nadella, Ravi K. ; Nakanotani, Takako ; Nielsen, René Ernst ; O'Donovan, Claire ; Omrani, Adel ; Osher, Yamima ; Ouali, Uta ; Pantovic-Stefanovic, Maja ; Pariwatcharakul, Pornjira ; Petite, Joanne ; Pfennig, Andrea ; Pica Ruiz, Yolanda ; Pilhatsch, Maximilian ; Pinna, Marco ; Pompili, Maurizio ; Porter, Richard ; Quiroz, Danilo ; Rabelo-da-Ponte, Francisco Diego ; Ramesar, Raj ; Rasgon, Natalie ; Ratta-apha, Woraphat ; Ratzenhofer, Michaela ; Redahan, Maria ; Reddy, M. S. ; Reif, Andreas ; Reininghaus, Eva Z. ; Richards, Jenny Gringer ; Ritter, Philipp ; Rybakowski, Janusz K. ; Sathyaputri, Leela ; Scippa, Ângela M. ; Simhandl, Christian ; Severus, Emanuel ; Smith, Daniel ; Smith, José ; Stackhouse Jr., Paul W. ; Stein, Dan J. ; Stilwell, Kellen ; Strejilevich, Sergio ; Su, Kuan-Pin ; Subramaniam, Mythily ; Sulaiman, Ahmad Hatim ; Suominen, Kirsi ; Tanra, Andi J. ; Tatebayashi, Yoshitaka ; Teh, Wen Lin ; Tondo, Leonardo ; Torrent, Carla ; Tuinstra, Daniel ; Uchida, Takahito ; Vaaler, Arne E. ; Veeh, Julia ; Vieta, Eduard ; Viswanath, Biju ; Yoldi-Negrete, Maria ; Yalcinkaya, Oguz Kaan ; Young, Allan H. ; Zgueb, Yosra ; Whybrow, Peter C.
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
Casey, Jillian P. ; Magalhães, Tiago R. ; Conroy, Judith M. ; Regan, Regina ; Shah, Naisha ; Anney, Richard ; Shields, Denis C. ; Abrahams, Brett S. ; Almeida, Joana ; Bacchelli, Elena ; Bailey, Anthony J. ; Baird, Gillian ; Battaglia, Agatino ; Berney, Tom ; Bolshakova, Nadia ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Cali, Phil ; Correia, Catarina ; Corsello, Christina ; Coutanche, Marc ; Dawson, Geraldine ; Jonge, Maretha de ; Delorme, Richard ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Foley, Suzanne ; Fombonne, Eric ; Freitag, Christine M. ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Green, Jonathan ; Guter, Stephen J. ; Hakonarson, Hakon ; Holt, Richard ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Kim, Cecilia ; Klauck, Sabine M. ; Kolevzon, Alexander ; Lamb, Janine A. ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Lord, Catherine ; Lund, Sabata C. ; Maestrini, Elena ; Mantoulan, Carine ; Marshall, Christian R. ; McConachie, Helen ; McDougle, Christopher J. ; McGrath, Jane ; McMahon, William M. ; Merikangas, Alison ; Miller, Judith ; Minopoli, Fiorella ; Mirza, Ghazala K. ; Munson, Jeff ; Nelson, Stanley F. ; Nygren, Gudrun ; Oliveira, Guiomar ; Pagnamenta, Alistair T. ; Papanikolaou, Katerina ; Parr, Jeremy R. ; Parrini, Barbara ; Pickles, Andrew ; Pinto, Dalila ; Piven, Joseph ; Posey, David J. ; Poustka, Annemarie ; Poustka, Fritz ; Ragoussis, Jiannis ; Roge, Bernadette ; Rutter, Michael L. ; Sequeira, Ana F. ; Soorya, Latha ; Sousa, Inês ; Sykes, Nuala ; Stoppioni, Vera ; Tancredi, Raffaella ; Tauber, Maïté ; Thompson, Ann P. ; Thomson, Susanne ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Vorstman, Jacob A. S. ; Wallace, Simon ; Wang, Kai ; Wassink, Thomas H. ; White, Kathy ; Wing, Kirsty ; Wittemeyer, Kerstin ; Yaspan, Brian L. ; Zwaigenbaum, Lonnie ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cantor, Rita M. ; Cook, Edwin H. ; Coon, Hilary ; Cuccaro, Michael L. ; Geschwind, Daniel H. ; Haines, Jonathan L. ; Hallmayer, Joachim ; Monaco, Anthony P. ; Nurnberger, John I. ; Pericak-Vance, Margaret Ann ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Sutcliffe, James S. ; Szatmari, Peter ; Vieland, Veronica J. ; Wijsman, Ellen M. ; Green, Andrew ; Gill, Michael ; Gallagher, Louise ; Vicente, Astrid M. ; Ennis, Sean
Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.
Chhabra, Harvinder Singh ; Tamai, Koji ; Alsebayel, Hana ; AlEissa, Sami ; Alqahtani, Yahya ; Arand, Markus ; Basu, Saumyajit ; Blattert, Thomas ; Bussières, André ; Campello, Marco ; Costanzo, Giuseppe ; Côté, Pierre ; Darwano, Bambang ; Franke, Jörg ; Garg, Bhavuk ; Hasan, Rumaisah ; Ito, Manabu ; Kamra, Komal ; Kandziora, Frank ; Kassim, Nishad ; Kato, So ; Lahey, Donna ; Mehta, Ketna ; Menezes, Cristiano M. ; Muehlbauer, Eric J. ; Mullerpatan, Rajani ; Pereira, Paulo ; Roberts, Lisa ; Ruosi, Carlo ; Sullivan, William ; Shetty, Ajoy Prasad ; Tucci, Carlos ; Wadhwa, Sanjay ; Alturkistany, Ahmed ; Busari, Jamiu O. ; Wang, Jeffrey C. ; Teli, Marco G. A. ; Rajasekaran, Shanmuganathan ; Mulukutla, Raghava D. ; Piccirillo, Michael ; Hsieh, Patrick C. ; Dohring, Edward J. ; Srivastava, Sudhir K. ; Larouche, Jeremie ; Vlok, Adriaan ; Nordin, Margareta
Coccolini, Federico ; Roberts, Derek ; Ansaloni, Luca ; Ivatury, Rao ; Gamberini, Emiliano ; Kluger, Yoram ; Moore, Ernest E. ; Coimbra, Raul ; Kirkpatrick, Andrew Wallace ; Pereira, Bruno M. ; Montori, Giulia ; Ceresoli, Marco ; Abu-Zidan, Fikri M. ; Sartelli, Massimo ; Velmahos, George C. ; Fraga, Gustavo Pereira ; Leppaniemi, Ari ; Tolonen, Matti ; Galante, Joseph ; Razek, Tarek ; Maier, Ron ; Bala, Miklosh ; Sakakushev, Boris ; Khokha, Vladimir ; Malbrain, Manu ; Agnoletti, Vanni ; Peitzman, Andrew B. ; Demetrashvili, Zaza ; Sugrue, Michael ; Di Saverio, Salomone ; Martzi, Ingo ; Soreide, Kjetil ; Biffl, Walter ; Ferrada, Paula ; Parry, Neil ; Montravers, Philippe ; Melotti, Rita Maria ; Salvetti, Francesco ; Valetti, Tino M. ; Scalea, Thomas ; Chiara, Osvaldo ; Cimbanassi, Stefania ; Kashuk, Jeffry L. ; Larrea, Martha ; Martinez Hernandez, Juan Alberto ; Lin, Heng-Fu ; Chirica, Mircea ; Arvieux, Catherine ; Bing, Camilla ; Horer, Tal ; Simone, Belinda De ; Masiakos, Peter T. ; Reva, Viktor ; De Angelis, Nicola ; Kike, Kaoru ; Balogh, Zsolt J. ; Fugazzola, Paola ; Tomasoni, Matteo ; Latifi, Rifat ; Naidoo, Noel ; Weber, Dieter ; Handolin, Lauri ; Inaba, Kenji ; Hecker, Andreas ; Yuan, Kuo-Ching ; Ordoñez, Carlos A. ; Rizoli, Sandro ; Gomes, Carlos Augusto ; De Moya, Marc ; Wani, Imtiaz ; Mefire, Alain Chichom ; Boffard, Ken ; Napolitano, Lena ; Catena, Fausto
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
Dubinski, Daniel ; Won, Sae-Yeon ; Rauch, Maximilian ; Behmanesh, Bedjan ; Ngassam, Lionel D. C. ; Baumgarten, Peter ; Senft, Christian ; Harter, Patrick Nikolaus ; Bernstock, Joshua D. ; Freiman, Thomas Michael ; Geßler, Florian
Background: The extent of preoperative peritumoral edema in glioblastoma (GBM) has been negatively correlated with patient outcome. As several ongoing studies are investigating T-cell based immunotherapy in GBM, we conducted this study to assess whether peritumoral edema with potentially increased intracranial pressure, disrupted tissue homeostasis and reduced local blood flow has influence on immune infiltration and affects survival.
Methods: A volumetric analysis of preoperative imaging (gadolinium enhanced T1 weighted MRI sequences for tumor size and T2 weighted sequences for extent of edema (including the infiltrative zone, gliosis etc.) was conducted in 144 patients using the BrainlabÒ software. Immunohistochemical staining was analyzed for lymphocytic- (CD 3+) and myeloid (CD15+) tumor infiltration. A retrospective analysis of patient-, surgical-, and molecular characteristics was performed using medical records.
Results: The edema to tumor ratio was neither associated with progression-free nor overall survival (p=0.90, p=0.74). However, GBM patients displaying IDH-1 wildtype had significantly higher edema to tumor ratio than patients displaying an IDH-1 mutation (p=0.01). Immunohistopathological analysis did not show significant differences in lymphocytic or myeloid tumor infiltration (p=0.78, p=0.74) between these groups.
Conclusion: In our cohort, edema to tumor ratio had no significant correlation with immune infiltration and outcome. However, patients with an IDH-1wildtype GBM had a significantly higher edema to tumor ratio compared to their IDH-1 mutated peer group. Further studies are necessary to elucidate the underlying mechanisms.