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Using e+e− annihilation data corresponding to a total integrated luminosity of 6.32 fb−1 collected at center-of-mass energies between 4.178 and 4.226 GeV with the BESIII detector, we perform an amplitude analysis of the decay D+s→K0SK0Sπ+ for the first time. An enhancement is observed in the K0SK0S mass spectrum near 1.7 GeV/c2, which was not seen in D+s→K+K−π+ in an earlier work, implying the existence of an isospin one partner of the f0(1710). The branching fraction of the decay D+s→K0SK0Sπ+ is determined to be B(D+s→K0SK0Sπ+)=(0.68±0.04stat±0.01syst)%.
Using J/ψ radiative decays from 9.0 billion J/ψ events collected by the BESIII detector, we search for di-muon decays of a CP-odd light Higgs boson (A0), predicted by many new physics models beyond the Standard Model, including the Next-to-Minimal Supersymmetric Standard Model. No evidence for the CP-odd light Higgs production is found, and we set 90% confidence level upper limits on the product branching fraction B(J/ψ→γA0)×B(A0→μ+μ−) in the range of (1.2−778.0)×10−9 for 0.212≤mA0≤3.0 GeV/c2. The new measurement is a 6-7 times improvement over our previous measurement, and is also slightly better than the BaBar measurement in the low-mass region for tanβ=1.
Using J/ψ radiative decays from 9.0 billion J/ψ events collected by the BESIII detector, we search for di-muon decays of a CP-odd light Higgs boson (A0), predicted by many new physics models beyond the Standard Model, including the Next-to-Minimal Supersymmetric Standard Model. No evidence for the CP-odd light Higgs production is found, and we set 90% confidence level upper limits on the product branching fraction B(J/ψ→γA0)×B(A0→μ+μ−) in the range of (1.2−778.0)×10−9 for 0.212≤mA0≤3.0 GeV/c2. The new measurement is a 6-7 times improvement over our previous measurement, and is also slightly better than the BaBar measurement in the low-mass region for tanβ=1.
Based on 3.19 fb−1 of e+e− collision data accumulated at the center-of-mass energy 4.178 GeV with the BESIII detector operating at the BEPCII collider, the electromagnetic Dalitz decay D∗0→D0e+e− is observed for the first time with a statistical significance of 13.2σ. The ratio of the branching fraction of D∗0→D0e+e− to that of D∗0→D0γ is measured to be (11.08±0.76±0.49)×10−3. By using the world average value of the branching fraction of D∗0→D0γ, the branching fraction of D∗0→D0e+e− is determined to be (3.91±0.27±0.17±0.10)×10−3, where the first uncertainty is statistical, the second systematic and the third external branching fractions.
The Born cross section of the process e+e−→ΛΛ¯ is measured at 33 center-of-mass energies between 3.51 and 4.60 GeV using data corresponding to the total integrated luminosity of 20.0 fb−1 collected with the BESIII detector at the BEPCII collider. Describing the energy dependence of the cross section requires a contribution from the ψ(3770)→ΛΛ¯ decay, which is fitted with a significance of 4.6-4.9σ including the systematic uncertainty. The lower bound on its branching fraction is 2.4×10−6 at the 90% confidence level (C.L.), at least an order of magnitude larger than expected from predictions using a scaling based on observed electronic widths. This result indicates the importance of effects from vector charmonium(-like) states when interpreting data in terms of e.g., electromagnetic structure observables. The data do not allow for definite conclusions on the interplay with other vector charmonium(-like) states, and we set 90% C.L.upper limits for the products of their electronic widths and the branching fractions.
Using (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector and a single-baryon tagging technique, we present the first observation of the decays ψ(3686)→Ξ(1530)0Ξ¯(1530)0 and Ξ(1530)0Ξ¯0. The branching fractions are measured to be B(ψ(3686)→Ξ(1530)0Ξ¯(1530)0)=(6.77±0.14±0.39)×10−5 and B(ψ(3686)→Ξ(1530)0Ξ¯0)=(0.53±0.04±0.03)×10−5. Here, the first and second uncertainties are statistical and systematic, respectively. In addition, the parameter associated with the angular distribution for the decay ψ(3686)→Ξ(1530)0Ξ¯(1530)0 is determined to be α=0.32±0.19±0.07, in agreement with theoretical predictions within one standard deviation.
The Born cross section of the process e+e−→ΛΛ¯ is measured at 33 center-of-mass energies between 3.51 and 4.60 GeV using data corresponding to the total integrated luminosity of 20.0 fb−1 collected with the BESIII detector at the BEPCII collider. Describing the energy dependence of the cross section requires a justification from the ψ(3770)→ΛΛ¯ decay, which is fitted with a significance of 4.9σ with the systematic uncertainty included. The lower bound on its branching fraction is 2.4×10−6 at the 90\% confidence level (C.L.), at least five times larger than expected from predictions using a simple scaling approach. This result indicates the importance of effects from vector charmonium(-like) when interpreting data in terms of {\it e.g.}, electromagnetic structure observables. There are no definite conclusions about the interplay with other vector charmonium(-like), and we set 90\% C.L.upper limits for the products of the electronic widths and the branching fractions.
Using a sample of 4.48×108 ψ(3686) events collected with the BESIII detector at the BEPCII collider, we study the two-photon decays of the pseudoscalar mesons π0, η, η′, η(1405), η(1475), η(1760), and X(1835) in J/ψ radiative decays using ψ(3686)→π+π−J/ψ events. The π0, η and η′ mesons are clearly observed in the two-photon mass spectra, and the branching fractions are determined to be B(J/ψ→γπ0→3γ)=(3.57±0.12±0.16)×10−5, B(J/ψ→γη→3γ)=(4.42±0.04±0.18)×10−4, and B(J/ψ→γη′→3γ)=(1.26±0.02±0.05)×10−4, where the first errors are statistical and the second systematic. No clear signal for η(1405), η(1475), η(1760) or X(1835) is observed in the two-photon mass spectra, and upper limits at the 90% confidence level on the product branching fractions are obtained.
Using a data sample of 448.1×106 𝜓(3686) events collected with the BESIII detector operating at the BEPCII, we perform search for the hadronic transition ℎ𝑐→𝜋+𝜋−𝐽/𝜓 via 𝜓(3686)→𝜋0ℎ𝑐. No signals of the transition are observed, and the upper limit on the product branching fraction ℬ(𝜓(3686)→𝜋0ℎ𝑐)ℬ(ℎ𝑐→𝜋+𝜋−𝐽/𝜓) at the 90% confidence level (C.L.) is determined to be 2.0×10−6. This is the most stringent upper limit to date.
Using a data sample of e+e− collision data corresponding to an integrated luminosity of 2.93 fb−1 collected with the BESIII detector at a center-of-mass energy of s=3.773GeV, we search for the singly Cabibbo-suppressed decays D0→π0π0π0, π0π0η, π0ηη and ηηη using the double tag method. The absolute branching fractions are measured to be B(D0→π0π0π0)=(2.0±0.4±0.3)×10−4, B(D0→π0π0η)=(3.8±1.1±0.7)×10−4 and B(D0→π0ηη)=(7.3±1.6±1.5)×10−4 with the statistical significances of 4.8σ, 3.8σ and 5.5σ, respectively, where the first uncertainties are statistical and the second ones systematic. No significant signal of D0→ηηη is found, and the upper limit on its decay branching fraction is set to be B(D0→ηηη)<1.3×10−4 at the 90% confidence level.
Relative fractions and phases of the intermediate decays are determined. With the detection efficiency estimated by the results of the amplitude analysis, the branching fraction of Dþ s → K−Kþπþπ0 decay is measured to be ð5.42 0.10stat 0.17systÞ%.
Decreased STARD10 expression is associated with defective insulin secretion in humans and mice
(2017)
Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the identity of the causal variants nor the gene(s) through which risk is conferred have been firmly established. Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer protein family. By integrating genetic fine-mapping and epigenomic annotation data and performing promoter-reporter and chromatin conformational capture (3C) studies in β cell lines, we localize the causal variant(s) at this locus to a 5 kb region that overlaps a stretch-enhancer active in islets. This region contains several highly correlated T2D-risk variants, including the rs140130268 indel. Expression QTL analysis of islet transcriptomes from three independent subject groups demonstrated that T2D-risk allele carriers displayed reduced levels of STARD10 mRNA, with no concomitant change in ARAP1 mRNA levels. Correspondingly, β-cell-selective deletion of StarD10 in mice led to impaired glucose-stimulated Ca2+ dynamics and insulin secretion and recapitulated the pattern of improved proinsulin processing observed at the human GWAS signal. Conversely, overexpression of StarD10 in the adult β cell improved glucose tolerance in high fat-fed animals. In contrast, manipulation of Arap1 in β cells had no impact on insulin secretion or proinsulin conversion in mice. This convergence of human and murine data provides compelling evidence that the T2D risk associated with variation at this locus is mediated through reduction in STARD10 expression in the β cell.