Refine
Author
- Alenius, Gerd-Marie (1)
- Alvarez, Victoria (1)
- Amin, Najaf (1)
- Amouyel, Philippe (1)
- Baldwin, Clinton (1)
- Barberger-Gateau, Pascale (1)
- Barton, Anne (1)
- Bayer, Anthony (1)
- Becker, Tim (1)
- Beecham, Gary W. (1)
- Beekly, Duane (1)
- Behrens, Frank (1)
- Bellenguez, Céline (1)
- Bennett, David A. (1)
- Berr, Claudine (1)
- Bettens, Karolien (1)
- Bihoreau, Marie-Thérèse (1)
- Bis, Joshua C. (1)
- Blacker, Deborah (1)
- Bluett, James (1)
- Boada, Mercè (1)
- Boerwinkle, Eric (1)
- Bonuccelli, Ubaldo (1)
- Bosco, Paolo (1)
- Bossù, Paola (1)
- Bowes, John (1)
- Brayne, Carol (1)
- Brice, Alexis (1)
- Broeckhoven, Christine Van (1)
- Brown, Kristelle (1)
- Brown, Matthew A. (1)
- Bruce, Ian N. (1)
- Bruijn, Renee F. A. G. de (1)
- Budu-Aggrey, Ashley (1)
- Burkhardt, Harald (1)
- Buxbaum, Joseph D. (1)
- Caffarra, Paolo (1)
- Campion, Dominique (1)
- Cantwell, Laura B. (1)
- Carrasquillo, Minerva M. (1)
- Choi, Seung-Hoan (1)
- Chouraki, Vincent (1)
- Clarimon, Jordi (1)
- Clarke, Robert (1)
- Collinge, John (1)
- Combarros, Onofre (1)
- Coto, Eliecer (1)
- Craig, David (1)
- Crane, Paul K. (1)
- Cruchaga, Carlos (1)
- Dartigues, Jean-François (1)
- DeStefano, Anita L. (1)
- Del Zompo, Maria (1)
- Deniz Naranjo, Maria Candida (1)
- Denning, Nicola (1)
- Deramecourt, Vincent (1)
- Donohoe, Gary (1)
- Dufouil, Carole (1)
- Duijn, Cornelia M. van (1)
- Dunstan, Melanie L. (1)
- Eiriksdottir, Gudny (1)
- Escott-Price, Valentina (1)
- Evans, Denis (1)
- Faber, Kelley M. (1)
- Farrer, Lindsay A. (1)
- Feletar, Marie (1)
- FitzGerald, Oliver (1)
- Fitzpatrick, Annette L. (1)
- Fiévet, Nathalie (1)
- Foroud, Tatiana M. (1)
- Fox, Nick C. (1)
- Frank-García, Ana (1)
- Fratiglioni, Laura (1)
- Galimberti, Daniela (1)
- Gallacher, John (1)
- Gerrish, Amy (1)
- Giardina, Emiliano (1)
- Gill, Michael (1)
- Goate, Alison M. (1)
- Graff, Caroline (1)
- Grenier-Boley, Benjamin (1)
- Gu, Wei (1)
- Gudnason, Vilmundur (1)
- Haines, Jonathan L. (1)
- Hakonarson, Hakon (1)
- Hamilton-Nelson, Kara L. (1)
- Hampel, Harald (1)
- Hannequin, Didier (1)
- Hanon, Olivier (1)
- Hardy, John (1)
- Harold, Denise (1)
- Harris, Tamara B. (1)
- Hebert, Harry L. (1)
- Helliwell, Philip (1)
- Hernández, Isabel (1)
- Hiltunen, Mikko (1)
- Ho, Pauline (1)
- Hofman, Albert (1)
- Hollingworth, Paul (1)
- Holmans, Peter (1)
- Holmes, Clive (1)
- Huentelman, Matthew J. (1)
- Huffmeier, Ulrike (1)
- Ibrahim-Verbaas, Carla A. (1)
- Ikram, M. Arfan (1)
- Ingelsson, Martin (1)
- Jager, Philip L. De (1)
- Johnson, Andrew D. (1)
- Johnston, Janet A. (1)
- Jones, Lesley (1)
- Jonsson, Palmi V. (1)
- Jun, Gyungah (1)
- Kamatani, Yoichiro (1)
- Kamboh, M. Ilyas (1)
- Kane, David (1)
- Kauwe, John S. K. (1)
- Keller, Lina (1)
- Korendowych, Eleanor (1)
- Kukull, Walter A. (1)
- Kunkle, Brian (1)
- Lambert, Jean-Charles (1)
- Lannfelt, Lars (1)
- Larson, Eric B. (1)
- Lathrop, Mark (1)
- Launer, Lenore J. (1)
- Letenneur, Luc (1)
- Lin, Chiao-Feng (1)
- Lleo, Alberto (1)
- Lopez, Oscar L. (1)
- Love, Seth (1)
- Lovestone, Simon (1)
- Lunetta, Kathryn L. (1)
- Maier, Wolfgang (1)
- Mancuso, Michelangelo (1)
- Martin, Eden R. (1)
- Marzo-Ortega, Helena (1)
- Massey, Jonathan (1)
- Mateo, Ignacio (1)
- Mayeux, Richard (1)
- Mayhaus, Manuel (1)
- McGuinness, Bernadette (1)
- McHugh, Neil (1)
- McManus, Ross (1)
- Mead, Simon (1)
- Mecocci, Patrizia (1)
- Moebus, Susanne (1)
- Montine, Thomas J. (1)
- Morgan, Ann W. (1)
- Morgan, Kevin (1)
- Morris, Derek W. (1)
- Mosley, Thomas H. (1)
- Myers, Amanda J. (1)
- Nacmias, Benedetta (1)
- Naj, Adam C. (1)
- Nalls, Michael A. (1)
- Nöthen, Markus Maria (1)
- O'Donovan, Michael C. (1)
- Owen, Michael J. (1)
- Packham, Jonathan (1)
- Panza, Francesco (1)
- Pasquier, Florence (1)
- Passmore, Peter (1)
- Pastor, Pau (1)
- Pericak-Vance, Margaret Ann (1)
- Perry, William (1)
- Pichler, Sabrina (1)
- Pilotto, Alberto (1)
- Powell, John F. (1)
- Proitsi, Petra (1)
- Psaty, Bruce M. (1)
- Ramirez, Alfredo (1)
- Razquin, Cristina (1)
- Reis, Andre (1)
- Reitz, Christiane (1)
- Richards, Alexander (1)
- Riemenschneider, Matthias (1)
- Ritchie, Karen (1)
- Rogaeva, Ekaterina (1)
- Rotter, Jerome I. (1)
- Rubinsztein, David C. (1)
- Ruiz, Agustin (1)
- Rujescu, Dan (1)
- Russo, Giancarlo (1)
- Ryan, Anthony W. (1)
- Sanchez Garcia, Florentino (1)
- Scarpini, Elio (1)
- Schellenberg, Gerard D. (1)
- Schmidt, Helena (1)
- Schmidt, Reinhold (1)
- Seshadri, Sudha (1)
- Siciliano, Gabriele (1)
- Sims, Rebecca (1)
- Sleegers, Kristel (1)
- Smith, Albert V. (1)
- Soininen, Hilkka (1)
- Solfrizzi, Vincenzo (1)
- Sorbi, Sandro (1)
- Spalletta, Gianfranco (1)
- St George-Hyslop, Peter (1)
- Steel, Kathryn (1)
- Thomas, Charlene (1)
- Thornton-Wells, Tricia A. (1)
- Todd, Stephen (1)
- Tsolaki, Magda (1)
- Tsuang, Debby W. (1)
- Tzourio, Christophe (1)
- Uebe, Steffen (1)
- Valladares, Otto (1)
- Vardarajan, Badri N. (1)
- Vedernikov, Alexey (1)
- Vronskaya, Maria (1)
- Wallace, Chris (1)
- Wallon, David (1)
- Wang, Li-San (1)
- Warren, Richard B. (1)
- Williams, Julie (1)
- Younkin, Steven G. (1)
- Yu, Lei (1)
- Zelenika, Diana (1)
- Zou, Fanggeng (1)
Document Type
- Article (2)
Language
- English (2)
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Institute
- Medizin (2)
Bowes, John ; Budu-Aggrey, Ashley ; Huffmeier, Ulrike ; Uebe, Steffen ; Steel, Kathryn ; Hebert, Harry L. ; Wallace, Chris ; Massey, Jonathan ; Bruce, Ian N. ; Bluett, James ; Feletar, Marie ; Morgan, Ann W. ; Marzo-Ortega, Helena ; Donohoe, Gary ; Morris, Derek W. ; Helliwell, Philip ; Ryan, Anthony W. ; Kane, David ; Warren, Richard B. ; Korendowych, Eleanor ; Alenius, Gerd-Marie ; Giardina, Emiliano ; Packham, Jonathan ; McManus, Ross ; FitzGerald, Oliver ; McHugh, Neil ; Brown, Matthew A. ; Ho, Pauline ; Behrens, Frank ; Burkhardt, Harald ; Reis, Andre ; Barton, Anne
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.
Escott-Price, Valentina ; Bellenguez, Céline ; Wang, Li-San ; Choi, Seung-Hoan ; Harold, Denise ; Jones, Lesley ; Holmans, Peter ; Gerrish, Amy ; Vedernikov, Alexey ; Richards, Alexander ; DeStefano, Anita L. ; Lambert, Jean-Charles ; Ibrahim-Verbaas, Carla A. ; Naj, Adam C. ; Sims, Rebecca ; Jun, Gyungah ; Bis, Joshua C. ; Beecham, Gary W. ; Grenier-Boley, Benjamin ; Russo, Giancarlo ; Thornton-Wells, Tricia A. ; Denning, Nicola ; Smith, Albert V. ; Chouraki, Vincent ; Thomas, Charlene ; Ikram, M. Arfan ; Zelenika, Diana ; Vardarajan, Badri N. ; Kamatani, Yoichiro ; Lin, Chiao-Feng ; Schmidt, Helena ; Kunkle, Brian ; Dunstan, Melanie L. ; Vronskaya, Maria ; Johnson, Andrew D. ; Ruiz, Agustin ; Bihoreau, Marie-Thérèse ; Reitz, Christiane ; Pasquier, Florence ; Hollingworth, Paul ; Hanon, Olivier ; Fitzpatrick, Annette L. ; Buxbaum, Joseph D. ; Campion, Dominique ; Crane, Paul K. ; Baldwin, Clinton ; Becker, Tim ; Gudnason, Vilmundur ; Cruchaga, Carlos ; Craig, David ; Amin, Najaf ; Berr, Claudine ; Lopez, Oscar L. ; Jager, Philip L. De ; Deramecourt, Vincent ; Johnston, Janet A. ; Evans, Denis ; Lovestone, Simon ; Letenneur, Luc ; Hernández, Isabel ; Rubinsztein, David C. ; Eiriksdottir, Gudny ; Sleegers, Kristel ; Goate, Alison M. ; Fiévet, Nathalie ; Huentelman, Matthew J. ; Gill, Michael ; Brown, Kristelle ; Kamboh, M. Ilyas ; Keller, Lina ; Barberger-Gateau, Pascale ; McGuinness, Bernadette ; Larson, Eric B. ; Myers, Amanda J. ; Dufouil, Carole ; Todd, Stephen ; Wallon, David ; Love, Seth ; Rogaeva, Ekaterina ; Gallacher, John ; St George-Hyslop, Peter ; Clarimon, Jordi ; Lleo, Alberto ; Bayer, Anthony ; Tsuang, Debby W. ; Yu, Lei ; Tsolaki, Magda ; Bossù, Paola ; Spalletta, Gianfranco ; Proitsi, Petra ; Collinge, John ; Sorbi, Sandro ; Sanchez Garcia, Florentino ; Fox, Nick C. ; Hardy, John ; Deniz Naranjo, Maria Candida ; Bosco, Paolo ; Clarke, Robert ; Brayne, Carol ; Galimberti, Daniela ; Scarpini, Elio ; Bonuccelli, Ubaldo ; Mancuso, Michelangelo ; Siciliano, Gabriele ; Moebus, Susanne ; Mecocci, Patrizia ; Del Zompo, Maria ; Maier, Wolfgang ; Hampel, Harald ; Pilotto, Alberto ; Frank-García, Ana ; Panza, Francesco ; Solfrizzi, Vincenzo ; Caffarra, Paolo ; Nacmias, Benedetta ; Perry, William ; Mayhaus, Manuel ; Lannfelt, Lars ; Hakonarson, Hakon ; Pichler, Sabrina ; Carrasquillo, Minerva M. ; Ingelsson, Martin ; Beekly, Duane ; Alvarez, Victoria ; Zou, Fanggeng ; Valladares, Otto ; Younkin, Steven G. ; Coto, Eliecer ; Hamilton-Nelson, Kara L. ; Gu, Wei ; Razquin, Cristina ; Pastor, Pau ; Mateo, Ignacio ; Owen, Michael J. ; Faber, Kelley M. ; Jonsson, Palmi V. ; Combarros, Onofre ; O'Donovan, Michael C. ; Cantwell, Laura B. ; Soininen, Hilkka ; Blacker, Deborah ; Mead, Simon ; Mosley, Thomas H. ; Bennett, David A. ; Harris, Tamara B. ; Fratiglioni, Laura ; Holmes, Clive ; Bruijn, Renee F. A. G. de ; Passmore, Peter ; Montine, Thomas J. ; Bettens, Karolien ; Rotter, Jerome I. ; Brice, Alexis ; Morgan, Kevin ; Foroud, Tatiana M. ; Kukull, Walter A. ; Hannequin, Didier ; Powell, John F. ; Nalls, Michael A. ; Ritchie, Karen ; Lunetta, Kathryn L. ; Kauwe, John S. K. ; Boerwinkle, Eric ; Riemenschneider, Matthias ; Boada, Mercè ; Hiltunen, Mikko ; Martin, Eden R. ; Schmidt, Reinhold ; Rujescu, Dan ; Dartigues, Jean-François ; Mayeux, Richard ; Tzourio, Christophe ; Hofman, Albert ; Nöthen, Markus Maria ; Graff, Caroline ; Psaty, Bruce M. ; Haines, Jonathan L. ; Lathrop, Mark ; Pericak-Vance, Margaret Ann ; Launer, Lenore J. ; Broeckhoven, Christine Van ; Farrer, Lindsay A. ; Duijn, Cornelia M. van ; Ramirez, Alfredo ; Seshadri, Sudha ; Schellenberg, Gerard D. ; Amouyel, Philippe ; Williams, Julie
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
- 1 to 2