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The production of prompt Λ+c baryons at midrapidity (|y|<0.5) was measured in central (0-10%) and mid-central (30-50%) Pb-Pb collisions at the center-of-mass energy per nucleon-nucleon pair sNN−−−√=5.02 TeV with the ALICE detector. The Λ+c production yield, the Λ+c/D0 production ratio, and the Λ+c nuclear modification factor RAA are reported. The results are more precise and more differential in transverse momentum (pT) and centrality with respect to previous measurements. The Λ+c/D0 ratio, which is enhanced with respect to the pp measurement for 4<pT<8 GeV/c, is described by theoretical calculations that model the charm-quark transport in the quark-gluon plasma and include hadronization via both coalescence and fragmentation mechanisms.
Measurement of beauty production via non-prompt D⁰ mesons in Pb-Pb collisions at √sNN = 5.02 TeV
(2022)
The production of non-prompt D0 mesons from beauty-hadron decays was measured at midrapidity (|y|<0.5) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of sNN−−−√=5.02 TeV with the ALICE experiment at the LHC. Their nuclear modification factor (RAA), measured for the first time down to pT=1 GeV/c in the 0−10% and 30−50% centrality classes, indicates a significant suppression, up to a factor of about three, for pT>5 GeV/c in the 0−10% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronisation mechanism. The ratio of the non-prompt to prompt D0-meson RAA is larger than unity for pT>4 GeV/c in the 0−10% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.
Measurement of beauty production via non-prompt D⁰ mesons in Pb–Pb
collisions at √sNN = 5.02 TeV
(2023)
The production of non-prompt D0 mesons from beauty-hadron decays was measured at midrapidity (|y|<0.5) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of sNN−−−√=5.02 TeV with the ALICE experiment at the LHC. Their nuclear modification factor (RAA), measured for the first time down to pT=1 GeV/c in the 0−10% and 30−50% centrality classes, indicates a significant suppression, up to a factor of about three, for pT>5 GeV/c in the 0−10% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronisation mechanism. The ratio of the non-prompt to prompt D0-meson RAA is larger than unity for pT>4 GeV/c in the 0−10% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.
Measurement of beauty production via non-prompt D⁰ mesons in Pb–Pb collisions at √sNN = 5.02 TeV
(2022)
The production of non-prompt D0 mesons from beauty-hadron decays was measured at midrapidity (|y|<0.5) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of sNN−−−√=5.02 TeV with the ALICE experiment at the LHC. Their nuclear modification factor (RAA), measured for the first time down to pT=1 GeV/c in the 0−10% and 30−50% centrality classes, indicates a significant suppression, up to a factor of about three, for pT>5 GeV/c in the 0−10% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronization mechanism. The ratio of the non-prompt to prompt D0-meson RAA is larger than unity for pT>4 GeV/c in the 0−10% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.
The measurement of Υ(1S), Υ(2S), and Υ(3S) yields as a function of the charged-particle multiplicity density, dNch/dη, using the ALICE experiment at the LHC, is reported in pp collisions at s√= 13 TeV. The Υ meson yields are measured at forward rapidity (2.5<y<4) in the dimuon decay channel, whereas the charged-particle multiplicity is defined at central rapidity (|η|<1). Both quantities are divided by their average value in minimum bias events to compute the self-normalized quantities. The increase of the self-normalized Υ(1S), Υ(2S), and Υ(3S) yields is found to be compatible with a linear scaling with the self-normalized dNch/dη, within the uncertainties. The self-normalized yield ratios of excited-to-ground Υ states are compatible with unity within uncertainties. Similarly, the measured double ratio of the self-normalized Υ(1S) to the self-normalized J/ψ yields, both measured at forward rapidity, is compatible with unity for self-normalized charged-particle multiplicities beyond one. The measurements are compared with theoretical predictions incorporating initial or final state effects.
Aim: Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE). Materials & methods: We conducted a genome-wide association study (GWAS) of 3.3 million autosomal SNPs in 893 European subjects with GGE – responsive or nonresponsive to lamotrigine, levetiracetam and valproic acid. Results: Our GWAS of AED response revealed suggestive evidence for association at 29 genomic loci (p <10-5) but no significant association reflecting its limited power. The suggestive associations highlight candidate genes that are implicated in epileptogenesis and neurodevelopment. Conclusion: This first GWAS of AED response in GGE provides a comprehensive reference of SNP associations for hypothesis-driven candidate gene analyses in upcoming pharmacogenetic studies.