Refine
Author
- Baune, Bernhard T. (2)
- Fullerton, Janice M. (2)
- Landén, Mikael (2)
- Mitchell, Philip B. (2)
- Reif, Andreas (2)
- Abé, Christoph (1)
- Adli, Mazda (1)
- Agartz, Ingrid (1)
- Akiyama, Kazufumi (1)
- Akudjedu, Theophilus N. (1)
- Akula, Nirmala (1)
- Alda, Martin (1)
- Allen, Nicholas B. (1)
- Amare, Azmeraw T. (1)
- Ames, David (1)
- Andre, Aleman (1)
- Andreassen, Ole A. (1)
- Ardau, Raffaella (1)
- Arias Vásquez, Alejandro (1)
- Arias, Bárbara (1)
- Armstrong, Nicola J. (1)
- Aubry, Jean-Michel (1)
- Backlund, Lena (1)
- Barrau, Caroline (1)
- Bastin, Mark E. (1)
- Batalla, Albert (1)
- Bauer, Jochen (1)
- Bauer, Michael (1)
- Baur, Ramona (1)
- Bellivier, Frank (1)
- Benabarre, Antonio (1)
- Bengesser, Susanne (1)
- Bergo, Felipe (1)
- Bhattacharjee, Abesh Kumar (1)
- Biederman, Joseph (1)
- Biernacka, Joanna (1)
- Birner, Armin (1)
- Blaine, Sara K. (1)
- Boedhoe, Premika (1)
- Bose, Anushree (1)
- Boukouaci, Wahid (1)
- Bralten, Janita (1)
- Brandeis, Daniel (1)
- Brem, Silvia (1)
- Brichant-Petitjean, Clara (1)
- Brodaty, Henry (1)
- Brooks, Samantha J. (1)
- Bröhl, Henrieke (1)
- Buitelaar, Jan K. (1)
- Busatto Filho, Geraldo (1)
- Bøen, Erlend (1)
- Bülow, Robin (1)
- Bürger, Christian (1)
- Calhoun, Vince D. (1)
- Calvo, Anna (1)
- Canales-Rodrı́guez, Erick Jorge (1)
- Canive, Jose M. (1)
- Cannon, Dara M. (1)
- Caparelli, Elisabeth C. (1)
- Castellanos, Francisco X. (1)
- Cavalleri, Gianpiero L. (1)
- Cearns, Micah (1)
- Cendes, Fernando (1)
- Cervantes, Pablo (1)
- Cervenka, Simon (1)
- Chaim-Avancini, Tiffany Moukbel (1)
- Chantiluke, Kaylita (1)
- Chen, Hsi-Chung (1)
- Chen, Qun-lin (1)
- Chen, Xiayu (1)
- Cheng, Yuqi (1)
- Chillotti, Caterina (1)
- Christakou, Anastasia (1)
- Cichon, Sven (1)
- Clark, Scott R. (1)
- Clark, Vincent P. (1)
- Coghill, David (1)
- Collste, Karin (1)
- Colom, Francesc (1)
- Connolly, Colm G. (1)
- Conzelmann, Annette (1)
- Cousijn, Janna (1)
- Crivello, Fabrice (1)
- Crow, Tim (1)
- Cruceanu, Cristiana (1)
- Cubillo, Ana (1)
- Czerski, Piotr M. (1)
- Cόrdova-Palomera, Aldo (1)
- Dalkner, Nina (1)
- Dannlowski, Udo (1)
- Dayer, Alexandre (1)
- De Zubicaray, Greig (1)
- DePaulo, J. Raymond (1)
- Deary, Ian J. (1)
- Degenhardt, Franziska (1)
- Del Zompo, Maria (1)
- Delanty, Norman (1)
- Demeter, Damion V. (1)
- Di Martino, Adriana (1)
- Dickie, Erin W (1)
- Dietsche, Bruno (1)
- Doan, N. Trung (1)
- Doherty, Colin P. (1)
- Doyle, Alysa (1)
- Durston, Sarah (1)
- Earl, Eric (1)
- Ehrlich, Stefan (1)
- Eijk, Liza van (1)
- Ekman, Carl Johan (1)
- Elvsåshagen, Torbjørn (1)
- Engberg, Goran (1)
- Epstein, Jeffery N. (1)
- Erhardt, Sophie (1)
- Fair, Damien A. (1)
- Falkai, Peter (1)
- Faraone, Stephen V. (1)
- Farde, Lars (1)
- Fatouros-Bergman, Helena (1)
- Ferensztajn-Rochowiak, Ewa (1)
- Fernndez, Guillen (1)
- Fisher, Simon E. (1)
- Flyckt, Lena (1)
- Forster, Katharina (1)
- Forstner, Andreas Josef (1)
- Foxe, John J. (1)
- Francks, Clyde (1)
- Franke, Barbara (1)
- Frisen, Louise (1)
- Frye, Mark A. (1)
- Fuentes-Claramonte, Paola (1)
- Garavan, Hugh (1)
- Garcia, Danielle do Santos (1)
- Gard, Sébastien (1)
- Garnham, Julie S. (1)
- Glahn, David C. (1)
- Goes, Fernando S. (1)
- Gotlib, Ian H. (1)
- Goudriaan, Anna E. (1)
- Grabe, Hans Jörgen (1)
- Grigoroiu-Serbanescu, Maria (1)
- Groenewold, Nynke A. (1)
- Grof, Paul (1)
- Grotegerd, Dominik (1)
- Gruber, Oliver (1)
- Guadalupe, Tulio (1)
- Gurholt, Tiril (1)
- Haavik, Jan (1)
- Hahn, Tim (1)
- Hansell, Narelle K. (1)
- Harris, Mathew A. (1)
- Hartman, Catharina (1)
- Hashimoto, Ryota (1)
- Hauser, Joanna (1)
- Hedberg, Mikael (1)
- Heilbronner, Urs (1)
- Herms, Stefan (1)
- Hernandez, Maria del Carmen Valdes (1)
- Heslenfeld, Dirk (1)
- Hester, Robert (1)
- Hibar, Derrek Paul (1)
- Ho, Beng-Choon (1)
- Ho, Tiffany C. (1)
- Hoekstra, Pieter J. (1)
- Hoffmann, Per (1)
- Hoogman, Martine (1)
- Hou, Liping (1)
- Hovik, Marie F. (1)
- Howells, Fleur M. (1)
- Hsu, Yi-Hsiang (1)
- Hugdahl, Kenneth (1)
- Huyser, Chaim (1)
- Ingvar, Martind (1)
- Irwin, Lourdes (1)
- Ishikawa, Akari (1)
- Jahanshad, Neda (1)
- Jamain, Stephane (1)
- James, Anthony (1)
- Jean-Paul, Fouche (1)
- Jernigan, Terry L. (1)
- Jiménez, Esther (1)
- Jönsson, Erik G. (1)
- Kahler, Claas (1)
- Kahn, Jean-Pierre (1)
- Kaleda, Vasily (1)
- Kassem, Layla (1)
- Kato, Tadafumi (1)
- Kelly, Clare (1)
- Kelsoe, John R. (1)
- Kerich, Michael (1)
- Keshavan, Matcheri S (1)
- Khadka, Sabin (1)
- Kircher, Tilo (1)
- Kittel-Schneider, Sarah (1)
- Kohls, Gregor (1)
- Kong, Xiang-Zhen (1)
- Konrad, Kerstin (1)
- Korucuoglu, Ozlem (1)
- Krug, Axel (1)
- Krämer, Bernd (1)
- Kuo, Po-Hsiu (1)
- Kusumi, Ichiro (1)
- Kwon, Jun Soo (1)
- König, Barbara (1)
- Laje, Gonzalo (1)
- Lambregts-Rommelse, Nanda (1)
- Lavebratt, Catharina (1)
- Le Clerc, Sigrid (1)
- Le Corvoisier, Philippe (1)
- Lebedeva, Irina (1)
- Leboyer, Marion (1)
- Leckband, Susan G. (1)
- Lenroot, Rhoshel (1)
- Lesch, Klaus-Peter J. (1)
- Li, Qinqin (1)
- Lim, Kelvin O. (1)
- Liu, Jia (1)
- Lochner, Christine (1)
- Lombardi, Laura (1)
- London, Edythe D. (1)
- Lonning, Vera (1)
- Lorenzetti, Valentina (1)
- Luciano, Michelle (1)
- Luijten, Maartje (1)
- Lundervold, Astri J. (1)
- Lázaro, Luisa (1)
- MacMaster, Frank P. (1)
- Mackey, Scott (1)
- Maingault, Sophie (1)
- Maj, Mario (1)
- Malmqvist, Anna (1)
- Malpas, Charles B. (1)
- Malt, Ulrik F. (1)
- Manchia, Mirko (1)
- Maniega, Susana Munoz (1)
- Martin-Santos, Rocio (1)
- Martinsson, Lina (1)
- Mataix-Cols, David (1)
- Mathias, Samuel R. (1)
- Mayer, Andrew R. (1)
- Mazoyer, Bernard (1)
- McCarthy, Hazel (1)
- McCarthy, Michael J. (1)
- McDonald, Colm (1)
- McElroy, Susan (1)
- McLellan, Quinn (1)
- McMahon, Francis J. (1)
- McMahon, Katie L. (1)
- McPhilemy, Genevieve (1)
- Meer, Dennis van der (1)
- Millischer, Vincent (1)
- Mitjans, Marina (1)
- Momenan, Reza (1)
- Mondimore, Francis Mark (1)
- Monteleone, Palmiero (1)
- Morales, Angelica M. (1)
- Moreira, José Carlos Vasques (1)
- Mueller, Bryon A. (1)
- Narayanaswamy, Janardhanan C. (1)
- Nerland, Stener (1)
- Nestor, Liam (1)
- Nievergelt, Caroline M. (1)
- Nigg, Joel T. (1)
- Nordvik, Jan-Egil (1)
- Novotny, Stephanie (1)
- Novák, Tomas (1)
- Nöthen, Markus Maria (1)
- O'Donovan, Claire (1)
- Oberwelland, Eileen (1)
- Oosterlaan, Jaap (1)
- Oranje, Bob (1)
- Orhan, Funda (1)
- Orr, Catherine (1)
- Overs, Bronwyn (1)
- Ozaki, Norio (1)
- O’Gorman, Ruth L. (1)
- Papiol, Sergi (1)
- Pauli, Paul (1)
- Paulus, Martin (1)
- Pfennig, Andrea (1)
- Piehl, Fredrik (1)
- Pisanu, Claudia (1)
- Plessen, Kerstin (1)
- Polier, Georg von (1)
- Pomarol-Clotet, Edith (1)
- Potash, James B. (1)
- Qiu, Jiang (1)
- Radua, Joaquim (1)
- Ramos-Quiroga, J. Antoni (1)
- Reddy, Y.C. Janardhan (1)
- Reininghaus, Eva (1)
- Richard, Jean-Romain (1)
- Rietschel, Marcella (1)
- Roberts, Gloria (1)
- Rosa, Pedro (1)
- Rouleau, Guy A. (1)
- Rubia, Katya (1)
- Rybakowski, Janusz K. (1)
- Sacchet, Matthew D. (1)
- Sachdev, Perminder S. (1)
- Salvador, Raymond (1)
- Saud, Alhusaini (1)
- Schalling, Martin (1)
- Schmaal, Lianne (1)
- Schofield, Peter R. (1)
- Schubert, Klaus Oliver (1)
- Schulze, Thomas Gerd (1)
- Schweizer, Barbara W. (1)
- Schweren, Lisanne (1)
- Schwieler, Lilly (1)
- Seidman, Larry J. (1)
- Seitz, Jochen (1)
- Serpa, Mauricio Henriques (1)
- Severino, Giovanni (1)
- Shaw, Philip (1)
- Shekhtman, Tatyana (1)
- Shilling, Paul D. (1)
- Shimoda, Katzutaka (1)
- Shumskaya, Elena (1)
- Silk, Timothy J. (1)
- Simhandl, Christian (1)
- Simmons, Alan N. (1)
- Simulionyte, Egle (1)
- Sinha, Rajita (1)
- Sjoerds, Zsuzsika (1)
- Slaney, Claire M. (1)
- Smelror, Runar Elle (1)
- Soliva, Joan Carlos (1)
- Solowij, Nadia (1)
- Spadoni, Jean-Louis (1)
- Sponheim, Scott R. (1)
- Squassina, Alessio (1)
- Stamm, Thomas (1)
- Stein, Dan J. (1)
- Stein, Elliot A. (1)
- Stevens, Michael (1)
- Stopkova, Pavla (1)
- Strike, Lachlan T. (1)
- Sudre, Gustavo (1)
- Sui, Jing (1)
- Tamm, Leanne (1)
- Tamouza, Ryad (1)
- Tekola-Ayele, Fasil (1)
- Temmingh, Hendrik S. (1)
- Thoma, Robert J. (1)
- Thompson, Paul M. (1)
- Tomyshev, Alexander S. (1)
- Tortorella, Alfonso (1)
- Tronchin, Giulia (1)
- Turecki, Gustavo (1)
- Turner, Jessica A. (1)
- Tzourio-Mazoyer, Nathalie (1)
- Uhlmann, Anne (1)
- Vance, Alasdair (1)
- Veeh, Julia (1)
- Veer, Ilya M. (1)
- Veltman, Dick J. (1)
- Venkatasubramanian, Ganesan (1)
- Victorsson, Pauliina (1)
- Vieta, Eduard (1)
- Vilarroya, Oscar (1)
- Vives-Gilabert, Yolanda (1)
- Voineskos, Aristotle N. (1)
- Vuletic, Daniella (1)
- Völzke, Henry (1)
- Walitza, Susanne (1)
- Walter, Henrik (1)
- Walton, Esther (1)
- Wardlaw, Joanna M. (1)
- Wen, Wei (1)
- Westlye, Lars T. (1)
- Whelan, Christopher D. (1)
- White, Tonya (1)
- Wiers, Reinout W. (1)
- Witt, Stephanie H. (1)
- Wittfeld, Katharina (1)
- Wright, Adam (1)
- Wright, Margaret J. (1)
- Yang, Tony T. (1)
- Yasuda, Clarissa L. (1)
- Yoncheva, Yuliya (1)
- Yucel, Murat (1)
- Yun, Je-Yeon (1)
- Zagury, Jean-François (1)
- Zandi, Peter P. (1)
- Zanetti, Marcus Vinicius (1)
- Zeeuw, Patrick de (1)
- Zhen, Zonglei (1)
- Zhu, Xing-xing (1)
- Ziegler, Georg Christoph (1)
- Zierhut, Kathrin (1)
- Zwiers, Marcel P. (1)
- de Bruttopilo, Sara Ambrosino (1)
- van Erp, Theo G.M. (1)
- van Holst, Ruth J. (1)
- van den Heuvel, Odile (1)
- Étain, Bruno (1)
- Ösby, Urban (1)
Language
- English (2)
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Keywords
- Genetics (1)
- Immunogenetics (1)
- Immunology (1)
- Psychiatric disorders (1)
Institute
- Medizin (2)
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Abé, Christoph ; Agartz, Ingrid ; Akudjedu, Theophilus N. ; Andre, Aleman ; Saud, Alhusaini ; Allen, Nicholas B. ; Ames, David ; Andreassen, Ole A. ; Arias Vásquez, Alejandro ; Armstrong, Nicola J. ; Bergo, Felipe ; Bastin, Mark E. ; Batalla, Albert ; Bauer, Jochen ; Baune, Bernhard T. ; Baur, Ramona ; Biederman, Joseph ; Blaine, Sara K. ; Boedhoe, Premika ; Bøen, Erlend ; Bose, Anushree ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Brodaty, Henry ; Bröhl, Henrieke ; Brooks, Samantha J. ; Buitelaar, Jan K. ; Bürger, Christian ; Bülow, Robin ; Calhoun, Vince D. ; Calvo, Anna ; Canales-Rodrı́guez, Erick Jorge ; Canive, Jose M. ; Cannon, Dara M. ; Caparelli, Elisabeth C. ; Castellanos, Francisco X. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Chaim-Avancini, Tiffany Moukbel ; Chantiluke, Kaylita ; Chen, Qun-lin ; Chen, Xiayu ; Cheng, Yuqi ; Christakou, Anastasia ; Clark, Vincent P. ; Coghill, David ; Connolly, Colm G. ; Conzelmann, Annette ; Cόrdova-Palomera, Aldo ; Cousijn, Janna ; Crow, Tim ; Cubillo, Ana ; Dannlowski, Udo ; de Bruttopilo, Sara Ambrosino ; Zeeuw, Patrick de ; Deary, Ian J. ; Delanty, Norman ; Demeter, Damion V. ; Di Martino, Adriana ; Dickie, Erin W ; Dietsche, Bruno ; Doan, N. Trung ; Doherty, Colin P. ; Doyle, Alysa ; Durston, Sarah ; Earl, Eric ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Epstein, Jeffery N. ; Fair, Damien A. ; Faraone, Stephen V. ; Fatouros-Bergman, Helena ; Fernndez, Guillen ; Busatto Filho, Geraldo ; Flyckt, Lena ; Forster, Katharina ; Jean-Paul, Fouche ; Foxe, John J. ; Fuentes-Claramonte, Paola ; Fullerton, Janice M. ; Garavan, Hugh ; Garcia, Danielle do Santos ; Gotlib, Ian H. ; Goudriaan, Anna E. ; Grabe, Hans Jörgen ; Groenewold, Nynke A. ; Grotegerd, Dominik ; Gruber, Oliver ; Gurholt, Tiril ; Haavik, Jan ; Hahn, Tim ; Hansell, Narelle K. ; Harris, Mathew A. ; Hartman, Catharina ; Hernandez, Maria del Carmen Valdes ; Heslenfeld, Dirk ; Hester, Robert ; Hibar, Derrek Paul ; Ho, Beng-Choon ; Ho, Tiffany C. ; Hoekstra, Pieter J. ; van Holst, Ruth J. ; Hoogman, Martine ; Hovik, Marie F. ; Howells, Fleur M. ; Hugdahl, Kenneth ; Huyser, Chaim ; Ingvar, Martind ; Irwin, Lourdes ; Ishikawa, Akari ; James, Anthony ; Jahanshad, Neda ; Jernigan, Terry L. ; Jönsson, Erik G. ; Kahler, Claas ; Kaleda, Vasily ; Kelly, Clare ; Kerich, Michael ; Keshavan, Matcheri S ; Khadka, Sabin ; Kircher, Tilo ; Kohls, Gregor ; Konrad, Kerstin ; Korucuoglu, Ozlem ; Krämer, Bernd ; Krug, Axel ; Kwon, Jun Soo ; Lambregts-Rommelse, Nanda ; Landén, Mikael ; Lázaro, Luisa ; Lebedeva, Irina ; Lenroot, Rhoshel ; Lesch, Klaus-Peter J. ; Li, Qinqin ; Lim, Kelvin O. ; Liu, Jia ; Lochner, Christine ; London, Edythe D. ; Lonning, Vera ; Lorenzetti, Valentina ; Luciano, Michelle ; Luijten, Maartje ; Lundervold, Astri J. ; Mackey, Scott ; MacMaster, Frank P. ; Maingault, Sophie ; Malpas, Charles B. ; Malt, Ulrik F. ; Mataix-Cols, David ; Martin-Santos, Rocio ; Mayer, Andrew R. ; McCarthy, Hazel ; Mitchell, Philip B. ; Mueller, Bryon A. ; Maniega, Susana Munoz ; Mazoyer, Bernard ; McDonald, Colm ; McLellan, Quinn ; McMahon, Katie L. ; McPhilemy, Genevieve ; Momenan, Reza ; Morales, Angelica M. ; Narayanaswamy, Janardhanan C. ; Moreira, José Carlos Vasques ; Nerland, Stener ; Nestor, Liam ; Nigg, Joel T. ; Nordvik, Jan-Egil ; Novotny, Stephanie ; Oberwelland, Eileen ; O’Gorman, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Orr, Catherine ; Overs, Bronwyn ; Pauli, Paul ; Paulus, Martin ; Plessen, Kerstin ; Polier, Georg von ; Pomarol-Clotet, Edith ; Qiu, Jiang ; Radua, Joaquim ; Ramos-Quiroga, J. Antoni ; Reddy, Y.C. Janardhan ; Reif, Andreas ; Roberts, Gloria ; Rosa, Pedro ; Rubia, Katya ; Sacchet, Matthew D. ; Sachdev, Perminder S. ; Salvador, Raymond ; Schmaal, Lianne ; Schweren, Lisanne ; Seidman, Larry J. ; Seitz, Jochen ; Serpa, Mauricio Henriques ; Shaw, Philip ; Shumskaya, Elena ; Silk, Timothy J. ; Simmons, Alan N. ; Simulionyte, Egle ; Sinha, Rajita ; Sjoerds, Zsuzsika ; Smelror, Runar Elle ; Soliva, Joan Carlos ; Solowij, Nadia ; Sponheim, Scott R. ; Stein, Dan J. ; Stein, Elliot A. ; Stevens, Michael ; Strike, Lachlan T. ; Sudre, Gustavo ; Sui, Jing ; Tamm, Leanne ; Temmingh, Hendrik S. ; Thoma, Robert J. ; Tomyshev, Alexander S. ; Tronchin, Giulia ; Turner, Jessica A. ; Uhlmann, Anne ; van Erp, Theo G.M. ; van den Heuvel, Odile ; Meer, Dennis van der ; Eijk, Liza van ; Vance, Alasdair ; Veer, Ilya M. ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vilarroya, Oscar ; Vives-Gilabert, Yolanda ; Voineskos, Aristotle N. ; Völzke, Henry ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Walton, Esther ; Wardlaw, Joanna M. ; Wen, Wei ; Westlye, Lars T. ; Whelan, Christopher D. ; White, Tonya ; Wiers, Reinout W. ; Wright, Margaret J. ; Wittfeld, Katharina ; Yang, Tony T. ; Yasuda, Clarissa L. ; Yoncheva, Yuliya ; Yucel, Murat ; Yun, Je-Yeon ; Zanetti, Marcus Vinicius ; Zhen, Zonglei ; Zhu, Xing-xing ; Ziegler, Georg Christoph ; Zierhut, Kathrin ; De Zubicaray, Greig ; Zwiers, Marcel P. ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde ; Farde, Lars ; Engberg, Goran ; Erhardt, Sophie ; Cervenka, Simon ; Schwieler, Lilly ; Piehl, Fredrik ; Collste, Karin ; Victorsson, Pauliina ; Malmqvist, Anna ; Hedberg, Mikael ; Orhan, Funda
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
(2021)
Le Clerc, Sigrid ; Lombardi, Laura ; Amare, Azmeraw T. ; Schubert, Klaus Oliver ; Hou, Liping ; Clark, Scott R. ; Papiol, Sergi ; Cearns, Micah ; Heilbronner, Urs ; Degenhardt, Franziska ; Tekola-Ayele, Fasil ; Hsu, Yi-Hsiang ; Shekhtman, Tatyana ; Adli, Mazda ; Akula, Nirmala ; Akiyama, Kazufumi ; Ardau, Raffaella ; Arias, Bárbara ; Aubry, Jean-Michel ; Backlund, Lena ; Bhattacharjee, Abesh Kumar ; Bellivier, Frank ; Benabarre, Antonio ; Bengesser, Susanne ; Biernacka, Joanna ; Birner, Armin ; Brichant-Petitjean, Clara ; Cervantes, Pablo ; Chen, Hsi-Chung ; Chillotti, Caterina ; Cichon, Sven ; Cruceanu, Cristiana ; Czerski, Piotr M. ; Dalkner, Nina ; Dayer, Alexandre ; Baune, Bernhard T. ; Del Zompo, Maria ; DePaulo, J. Raymond ; Étain, Bruno ; Jamain, Stephane ; Falkai, Peter ; Forstner, Andreas Josef ; Frisen, Louise ; Frye, Mark A. ; Fullerton, Janice M. ; Gard, Sébastien ; Garnham, Julie S. ; Goes, Fernando S. ; Grigoroiu-Serbanescu, Maria ; Grof, Paul ; Hashimoto, Ryota ; Hauser, Joanna ; Herms, Stefan ; Hoffmann, Per ; Jiménez, Esther ; Kahn, Jean-Pierre ; Kassem, Layla ; Kuo, Po-Hsiu ; Kato, Tadafumi ; Kelsoe, John R. ; Kittel-Schneider, Sarah ; Ferensztajn-Rochowiak, Ewa ; König, Barbara ; Kusumi, Ichiro ; Laje, Gonzalo ; Landén, Mikael ; Lavebratt, Catharina ; Leckband, Susan G. ; Tortorella, Alfonso ; Manchia, Mirko ; Martinsson, Lina ; McCarthy, Michael J. ; McElroy, Susan ; Colom, Francesc ; Millischer, Vincent ; Mitjans, Marina ; Mondimore, Francis Mark ; Monteleone, Palmiero ; Nievergelt, Caroline M. ; Nöthen, Markus Maria ; Novák, Tomas ; O'Donovan, Claire ; Ozaki, Norio ; Ösby, Urban ; Pfennig, Andrea ; Potash, James B. ; Reif, Andreas ; Reininghaus, Eva ; Rouleau, Guy A. ; Rybakowski, Janusz K. ; Schalling, Martin ; Schofield, Peter R. ; Schweizer, Barbara W. ; Severino, Giovanni ; Shilling, Paul D. ; Shimoda, Katzutaka ; Simhandl, Christian ; Slaney, Claire M. ; Pisanu, Claudia ; Squassina, Alessio ; Stamm, Thomas ; Stopkova, Pavla ; Maj, Mario ; Turecki, Gustavo ; Vieta, Eduard ; Veeh, Julia ; Witt, Stephanie H. ; Wright, Adam ; Zandi, Peter P. ; Mitchell, Philip B. ; Bauer, Michael ; Alda, Martin ; Rietschel, Marcella ; McMahon, Francis J. ; Schulze, Thomas Gerd ; Spadoni, Jean-Louis ; Boukouaci, Wahid ; Richard, Jean-Romain ; Le Corvoisier, Philippe ; Barrau, Caroline ; Zagury, Jean-François ; Leboyer, Marion ; Tamouza, Ryad
Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li (p < 1 × 10−3; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response.
- 1 to 2