Refine
Year of publication
Document Type
- Preprint (611)
- Article (435)
- Conference Proceeding (1)
- Report (1)
- Working Paper (1)
Has Fulltext
- yes (1049)
Is part of the Bibliography
- no (1049)
Keywords
- Heavy Ion Experiments (20)
- Hadron-Hadron scattering (experiments) (11)
- Hadron-Hadron Scattering (8)
- Heavy-ion collision (5)
- Collective Flow (4)
- Quark-Gluon Plasma (4)
- Jets (3)
- Jets and Jet Substructure (3)
- (surface) partial differential equations (2)
- 3D spatio-temporal resolved mathematical models (2)
- Atmospheric chemistry (2)
- COVID-19 (2)
- Epilepsy (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- Finite Volumes (2)
- Germany (2)
- Heavy Quark Production (2)
- Immunotherapy (2)
- LHC (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Non-small cell lung cancer (2)
- Oncology (2)
- Particle Correlations and Fluctuations (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Quarkonium (2)
- acute myeloid leukemia (2)
- computational virology (2)
- immunotherapy (2)
- massively parallel multigrid solvers (2)
- realistic geometries (2)
- viral dynamics (2)
- within-host viral modelling (2)
- 140Ce (1)
- 900 GeV (1)
- ACURATE neo (1)
- AIS (1)
- ALICE (1)
- ALICE detector (1)
- APRI (1)
- ASCT (1)
- Accelerators & Beams (1)
- Acute myeloid leukemia (1)
- Adherens junctions (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Anti-nuclei (1)
- Antibody therapy (1)
- Artificial Intelligence (1)
- Atomic and Molecular Physics (1)
- Atomic, Molecular & Optical (1)
- BCOR (1)
- BCORL1 (1)
- BI1361849 (1)
- Bamlanivimab (1)
- Biodiversity Data (1)
- Biogeochemistry (1)
- Biomarkers (1)
- Biomonitoring (1)
- Bladder cancer (1)
- Blood-brain barrier (1)
- Bloodstream infection (1)
- Bloodstream infections (1)
- Boosted Jets (1)
- Botanical Collections (1)
- Brain tumor (1)
- Burkholderia arboris (1)
- CD36 (1)
- CHIP (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- CTLA-4 (1)
- CV9202 (1)
- CVID (1)
- Cancer (1)
- Cancer genomics (1)
- Casirivimab (1)
- Centrality Class (1)
- Centrality Selection (1)
- Charged-particle multiplicity (1)
- Checkpoint inhibitor (1)
- Clinical Trials and Observations (1)
- Clinical trial (1)
- Cluster (1)
- Cohort studies (1)
- Collective Flow, (1)
- Conservation (1)
- Correlative electron and light microscopy (1)
- DBS (1)
- DSS /AOM (1)
- Diagnostic markers (1)
- Digitization (1)
- Electromagnetic transitions (1)
- Electron tomography (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Entomology (1)
- Epidemiology (1)
- European Society for Immunodeficiencies (ESID) (1)
- Everolimus resistance (1)
- Evidence-based guidelines (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extended donor criteria (1)
- FDG-PET/CT (1)
- FIB-4 (1)
- Fibre/foam sandwich radiator (1)
- Freshwater ecology (1)
- GdIr2Si2 (1)
- German PID-NET registry (1)
- Glioma (1)
- Graft function (1)
- Graft survival (1)
- Gram negative bacteria (1)
- HBV (1)
- HDAC-inhibition (1)
- HNSCC (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Hard Scattering (1)
- Head neck cancer (1)
- Heavy Ion Experiment (1)
- Hematology (1)
- Hematopoietic stem cell transplantation (1)
- Herbaria (1)
- Hypofractionated radiotherapy (1)
- ICU (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- ISS (1)
- IgG substitution therapy (1)
- Imdevimab (1)
- Immunomonitoring (1)
- Incidence (1)
- Induction therapy (1)
- Intensive care units (1)
- Invariant Mass Distribution (1)
- Invasive species (1)
- Ionisation energy loss (1)
- Isoflurane (1)
- Jet Physics (1)
- Jet Substructure (1)
- Lesion (1)
- Liver transplantation (1)
- Locally advanced (1)
- Long term output (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- MACS (1)
- MRI (1)
- Magnetic resonance imaging (MRI) (1)
- Marginal grafts (1)
- Material budget (1)
- Mechanisms of disease (1)
- Minimum Bias (1)
- Models & methods for nuclear reactions (1)
- Molecular diagnostic testing (1)
- Molecular matched therapy (1)
- Molecular medicine (1)
- Molecular profiling (1)
- Monte Carlo (1)
- Mott transition (1)
- Multi-Parton Interactions (1)
- Multi-wire proportional drift chamber (1)
- Multiple parton interactions (1)
- Multivariate analysis (1)
- Myeloid Neoplasia (1)
- NMR spectroscopy (1)
- NSCLC (1)
- Neural network (1)
- Neutron physics (1)
- Neutropenia (1)
- Nivolumab (1)
- Nuclear reactions (1)
- Organ rinse (1)
- Organ shortage (1)
- Osteoporosis (1)
- P2X7 receptor (1)
- PD-1 (1)
- PD-1 inhibitor (1)
- PDEs (1)
- PID prevalence (1)
- PYTHIA (1)
- Particle and Resonance Production (1)
- Pb–Pb collisions (1)
- Phylogenomics (1)
- Pneumonia (1)
- Poecilia mexicana (1)
- Polarization (1)
- Population genetics (1)
- Production Cross Section (1)
- Properties of Hadrons (1)
- Psoriasis vulgaris (1)
- QCD (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- RNA (1)
- RNA decay (1)
- Radiation detectors (1)
- Radiative capture (1)
- Radical cystectomy (1)
- Radiotherapy (1)
- Rapidity Range (1)
- Registries (1)
- Relativistic heavy-ion collisions (1)
- Renal cell carcinoma (1)
- Research Infrastructure (1)
- Resolution Parameter (1)
- Resonance reactions (1)
- SMAD (1)
- Semantics (1)
- Sexual selection (1)
- Status epilepticus (1)
- Stenotrophomonas maltophilia (1)
- Stentoplasty (1)
- Systematic Uncertainty (1)
- T cell/histiocyte rich large B cell lymphoma (1)
- TAVR (1)
- TGFβ (1)
- TR (1)
- Tacrolimus (1)
- Targeted therapy (1)
- Taxonomy (1)
- Thermodynamics (1)
- Thoracic trauma (1)
- Thrombotic microangiopathy (1)
- Thrombotic thrombocytopenic purpura (1)
- Time Projection Chamber (1)
- TmRh2Si2 (1)
- Tracking (1)
- Transition radiation detector (1)
- Transitional cell carcinoma (1)
- Transverse momentum (1)
- Treatment (1)
- Trigger (1)
- Tumor growth (1)
- Urothelial cancer (1)
- VIM (1)
- Vector Boson Production (1)
- Vertebral augmentation (1)
- Vertebral body stenting (1)
- Vertebral fracture (1)
- Viral load (1)
- X-ray crystallography (1)
- X-ray irradiation (1)
- Xenon-based gas mixture (1)
- acoustic radiation force impulse imaging (1)
- adaptation (1)
- advanced melanoma (1)
- adversity (1)
- age (1)
- allostasis (1)
- anti-epileptic drug (1)
- aortic stenosis (1)
- autologous stem cell transplantation (1)
- biomarker (1)
- blood cell mutations (1)
- brain metastases (1)
- brain metastasis (1)
- brain shift (1)
- burkholderia (1)
- burkholderia cepacia complex infections (1)
- calcium dynamics (1)
- calcium-independent phospholipase A2β (1)
- capture (1)
- cdk2/cyclin A (1)
- cerebral pseudoprogression (1)
- cerium (1)
- chemoconvulsant (1)
- chemotherapy (1)
- chronic colitis (1)
- clonal dominance (1)
- clonal haematopoiesis (1)
- clonal hematopoiesis (1)
- clonal transfer (1)
- colon cancer (1)
- community assembly (1)
- complete response (1)
- complex systems (1)
- coping (1)
- correlated electrons (1)
- cross-section (1)
- cytarabine dose (1)
- dE/dx (1)
- detailed modeling (1)
- detector (1)
- diffuse large B cell lymphoma (1)
- discontinuation (1)
- discontinuous dose dependency (1)
- disease outbreaks (1)
- disease progression (1)
- disorder (1)
- distributed computation (1)
- dynamic system (1)
- ectosomes (1)
- elderly (1)
- electrical stimulation (1)
- electrophoresis (1)
- epileptogenesis (1)
- essential tremor (1)
- everolimus (1)
- exosomes (1)
- experimental results (1)
- extracellular vesicles (1)
- familial amyloid nephropathy with urticaria and deafness (1)
- female choice (1)
- fibrotest (1)
- flux growth (1)
- gel (1)
- gene expression profiling (1)
- gene signature (1)
- generalized additive model (1)
- genome (1)
- glioblastoma (1)
- guidelines (1)
- head and neck squamous cell carcinoma (1)
- healthcare systems (1)
- heart failure (1)
- heavy ion experiments (1)
- hematopoietic stem cells (1)
- hematopoietic stress (1)
- hepatitis C virus (1)
- hepatitis C virus (HCV) (1)
- hippocampal sclerosis (1)
- homeostasis (1)
- host response (1)
- hybrid (1)
- hypoxia (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitors (1)
- immune checkpoint inhibitors (ICI) (1)
- immune modulation (1)
- immune related adverse events (irAE) (1)
- infections (1)
- inflammasome (1)
- inflammation (1)
- information storage (1)
- inpatient hospital admissions (1)
- interleukin-1β (1)
- leukemia (1)
- liver metastasis (1)
- local information dynamics (1)
- lockdown (1)
- loss-of-function (1)
- low-dose radiation therapy (1)
- lung cancer (1)
- mRNA active cancer immunotherapy (1)
- magnetism (1)
- mathematical models of viral RNA cycle (1)
- medical device (1)
- medical informatics initiative (1)
- mental health (1)
- metastatic renal cell carcinoma (1)
- microbial colonization (1)
- microparticles (1)
- microvesicles (1)
- minimal information requirements (1)
- mouthwash (1)
- mouthwash solution (1)
- n_TOF (1)
- neoadjuvant immunochemotherapy (1)
- neural dynamics (1)
- neurological complication (1)
- neurological side effects (1)
- neuron (1)
- neutron (1)
- nodular lymphocyte predominant Hodgkin lymphoma (1)
- non-independent mate choice (1)
- non-invasive fibrosis assessment (1)
- noncoding RNA (1)
- ntracellular signaling (1)
- nucleosynthesis (1)
- organic conductor (1)
- outbreak (1)
- p+p collisions (1)
- p47phox (1)
- pandemic (1)
- parallel (1)
- parameter estimation (1)
- patterns of progression (1)
- pembrolizumab (1)
- perioperative ischemia (1)
- phase IV (1)
- point shear wave elastography (1)
- postoperative radiochemotherapy (1)
- postoperative radiotherapy (1)
- predator recognition (1)
- predictive coding (1)
- pressure (1)
- primary immunodeficiency (PID) (1)
- propensity score matching (1)
- pulsed-field (1)
- quark gluon plasma (1)
- registry for primary immunodeficiency (1)
- reproducibility (1)
- rigor (1)
- risk stratification (1)
- s-process (1)
- second-line (1)
- second-line immunotherapy (1)
- soil bacteria communities (1)
- somatic mutations (1)
- spatio-temporal analysis (1)
- standardization (1)
- status epilepticus (1)
- stereotactic radiosurgery (1)
- stress (1)
- survival (1)
- targeted therapy (1)
- temporal lobe epilepsy (1)
- transcatheter aortic valve replacement (1)
- transfemoral (1)
- transient elastography (1)
- treatment resistance (1)
- tumor microenvironment (1)
- university hospitals (1)
- uveal melanoma (1)
- variable selection (1)
- ventralis intermedius nucleus (1)
- visual system (1)
- voltage sensitive dye imaging (1)
Institute
- Physik (955)
- Frankfurt Institute for Advanced Studies (FIAS) (853)
- Informatik (822)
- Medizin (66)
- Geowissenschaften (9)
- Biowissenschaften (5)
- ELEMENTS (3)
- Informatik und Mathematik (3)
- Institut für Ökologie, Evolution und Diversität (3)
- Biochemie und Chemie (2)
The Tarim River basin, located in Xinjiang, NW China, is the largest endorheic river basin in China and one of the largest in all of Central Asia. Due to the extremely arid climate, with an annual precipitation of less than 100 mm, the water supply along the Aksu and Tarim rivers solely depends on river water. This is linked to anthropogenic activities (e.g., agriculture) and natural and semi-natural ecosystems as both compete for water. The ongoing increase in water consumption by agriculture and other human activities in this region has been enhancing the competition for water between human needs and nature. Against this background, 11 German and 6 Chinese universities and research institutes have formed the consortium SuMaRiO (Sustainable Management of River Oases along the Tarim River; http://www.sumario.de), which aims to create a holistic picture of the availability of water resources in the Tarim River basin and the impacts on anthropogenic activities and natural ecosystems caused by the water distribution within the Tarim River basin. On the basis of the results from field studies and modeling approaches as well as from suggestions by the relevant regional stakeholders, a decision support tool (DST) will be implemented that will then assist stakeholders in balancing the competition for water, acknowledging the major external effects of water allocation to agriculture and to natural ecosystems. This consortium was formed in 2011 and is funded by the German Federal Ministry of Education and Research. As the data collection phase was finished this year, the paper presented here brings together the results from the fields from the disciplines of climate modeling, cryology, hydrology, agricultural sciences, ecology, geoinformatics, and social sciences in order to present a comprehensive picture of the effects of different water availability schemes on anthropogenic activities and natural ecosystems along the Tarim River. The second objective is to present the project structure of the whole consortium, the current status of work (i.e., major new results and findings), explain the foundation of the decision support tool as a key product of this project, and conclude with application recommendations for the region. The discharge of the Aksu River, which is the major tributary of the Tarim, has been increasing over the past 6 decades. From 1989 to 2011, agricultural area more than doubled: cotton became the major crop and there was a shift from small-scale to large-scale intensive farming. The ongoing increase in irrigated agricultural land leads to the increased threat of salinization and soil degradation caused by increased evapotranspiration. Aside from agricultural land, the major natural and semi-natural ecosystems are riparian (Tugai) forests, shrub vegetation, reed beds, and other grassland, as well as urban and peri-urban vegetation. Within the SuMaRiO cluster, focus has been set on the Tugai forests, with Populus euphratica as the dominant tree species, because these forests belong to the most productive and species-rich natural ecosystems of the Tarim River basin. At sites close to the groundwater, the annual stem diameter increments of Populus euphratica correlated with the river runoffs of the previous year. However, the natural river dynamics cease along the downstream course and thus hamper the recruitment of Populus euphratica. A study on the willingness to pay for the conservation of the natural ecosystems was conducted to estimate the concern of the people in the region and in China's capital. These household surveys revealed that there is a considerable willingness to pay for conservation of the natural ecosystems, with mitigation of dust and sandstorms considered the most important ecosystem service. Stakeholder dialogues contributed to creating a scientific basis for a sustainable management in the future.
Background: Acquired thrombotic thrombocytopenic Purpura (aTTP) is a life-threatening ultra-orphan disease with a reported annual incidence between 1.5 and 6.0 cases per million in Europe and mainly affecting otherwise young and healthy adults aged 40 years on average. The goal of this study was to assess the incidence of aTTP in Germany.
Methods: A systematic review was performed to determine the published evidence on the aTTP epidemiology in Germany. To obtain additional evidence on the proportion of aTTP cases within the national Thrombotic Microangiopathy (TMA) population a hospital-level study was performed, using a retrospective data collection approach. Diagnosis of aTTP was confirmed if ADAMTS13 level were < 10% and/or the medical records explicitly mentioned aTTP diagnosis. The aggregated hospital data were then projected to the national level using logistic regression techniques.
Results: The systematic literature search did not provide incidence estimates of aTTP in Germany. Eight centers (≈27% of the top 30 TMA hospitals) delivered data according to a predefined data collection form. On average (year 2014–2016) a total number of 172 aTTP episodes per year was projected (95% confidence interval [95%CI]: 132–212). The majority were newly diagnosed aTTP cases (n = 121; 95%CI: 105–129), and 51 were recurrent aTTP cases (95%CI: 27–84). The average annual projected incidence (year 2014–2016) of aTTP episodes was 2.10 per million inhabitants in Germany (95%CI: 1.60–2.58).
Conclusions: The determined annual incidence of newly diagnosed aTTP cases and the overall annual incidence of aTTP episodes in Germany confirm the ultra-orphan character of aTTP. An external validation against international registries (France, UK and USA) shows that our findings are quite comparable with those international incidence rates.
HADES is a fixed target experiment using SIS18 heavy-ion beams. It investigates the microscopic properties of matter formed in heavy-ion, proton and pion - induced reactions in the 1-3.5 GeV/u energy regime. In 2014 HADES used a secondary pion beam produced by interaction between high-intensity nitrogen primary beam and a beryllium target. In these conditions beam losses, generated by slow extraction and beam transport to the experimental area, led to activation of the beam line elements and triggered radiation alarms. The primary beam intensity had to be reduced and the beam optics modified in order to keep radiation levels within the allowed limits. Similar beam conditions are requested by HADES experiment for upcoming run in 2018 and in the following years. Therefore, a number of measures have been proposed to improve beam transmission and quality. These measures are: additional shielding, additional beam instrumentation, modification of beam optics and increase of vacuum chambers' apertures in critical locations. The optics study and preliminary results of FLUKA simulations for optimization of location of loss detectors are presented.
Mathematical models of virus dynamics have not previously acknowledged spatial resolution at the intracellular level despite substantial arguments that favor the consideration of intracellular spatial dependence. The replication of the hepatitis C virus (HCV) viral RNA (vRNA) occurs within special replication complexes formed from membranes derived from endoplasmatic reticulum (ER). These regions, termed membranous webs, are generated primarily through specific interactions between nonstructural virus-encoded proteins (NSPs) and host cellular factors. The NSPs are responsible for the replication of the vRNA and their movement is restricted to the ER surface. Therefore, in this study we developed fully spatio-temporal resolved models of the vRNA replication cycle of HCV. Our simulations are performed upon realistic reconstructed cell structures—namely the ER surface and the membranous webs—based on data derived from immunostained cells replicating HCV vRNA. We visualized 3D simulations that reproduced dynamics resulting from interplay of the different components of our models (vRNA, NSPs, and a host factor), and we present an evaluation of the concentrations for the components within different regions of the cell. Thus far, our model is restricted to an internal portion of a hepatocyte and is qualitative more than quantitative. For a quantitative adaption to complete cells, various additional parameters will have to be determined through further in vitro cell biology experiments, which can be stimulated by the results deccribed in the present study.
Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research. To date, spatial resolution has only rarely been analyzed in computational/biophysical descriptions of virus replication dynamics. However, it is widely acknowledged that intracellular spatial dependence is a crucial component of virus life cycles. The hepatitis C virus-encoded NS5A protein is an endoplasmatic reticulum (ER)-anchored viral protein and an essential component of the virus replication machinery. Therefore, we simulate NS5A dynamics on realistic reconstructed, curved ER surfaces by means of surface partial differential equations (sPDE) upon unstructured grids. We match the in silico NS5A diffusion constant such that the NS5A sPDE simulation data reproduce experimental NS5A fluorescence recovery after photobleaching (FRAP) time series data. This parameter estimation yields the NS5A diffusion constant. Such parameters are needed for spatial models of HCV dynamics, which we are developing in parallel but remain qualitative at this stage. Thus, our present study likely provides the first quantitative biophysical description of the movement of a viral component. Our spatio-temporal resolved ansatz paves new ways for understanding intricate spatial-defined processes central to specfic aspects of virus life cycles.
Background: Since there is no standardized and effective treatment for advanced uveal melanoma (UM), the prognosis is dismal once metastases develop. Due to the availability of immune checkpoint blockade (ICB) in the real-world setting, the prognosis of metastatic UM has improved. However, it is unclear how the presence of hepatic and extrahepatic metastasis impacts the response and survival after ICB. Methods: A total of 178 patients with metastatic UM treated with ICB were included in this analysis. Patients were recruited from German skin cancer centers and the German national skin cancer registry (ADOReg). To investigate the impact of hepatic metastasis, two cohorts were compared: patients with liver metastasis only (cohort A, n = 55) versus those with both liver and extra-hepatic metastasis (cohort B, n = 123). Data were analyzed in both cohorts for response to treatment, progression-free survival (PFS), and overall survival (OS). The survival and progression probabilities were calculated with the Kaplan–Meier method. Log-rank tests, χ2 tests, and t-tests were performed to detect significant differences between both cohorts. Results: The median OS of the overall population was 16 months (95% CI 13.4–23.7) and the median PFS, 2.8 months (95% CI 2.5–3.0). The median OS was longer in cohort B than in cohort A (18.2 vs. 6.1 months; p = 0.071). The best objective response rate to dual ICB was 13.8% and to anti-PD-1 monotherapy 8.9% in the entire population. Patients with liver metastases only had a lower response to dual ICB, yet without significance (cohort A 8.7% vs. cohort B 16.7%; p = 0.45). Adverse events (AE) occurred in 41.6%. Severe AE were observed in 26.3% and evenly distributed between both cohorts. Conclusion: The survival of this large cohort of patients with advanced UM was more favorable than reported in previous benchmark studies. Patients with both hepatic and extrahepatic metastasis showed more favorable survival and higher response to dual ICB than those with hepatic metastasis only.
Background: We aimed to determine the association between seizure termination and side effects of isoflurane for the treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensive care units (neuro-ICUs).
Methods: This was a multicenter retrospective study of patients with RSE/SRSE treated with isoflurane for status epilepticus termination admitted to the neuro-ICUs of nine German university centers during 2011–2018.
Results: We identified 45 patients who received isoflurane for the treatment of RSE/SRSE. During isoflurane treatment, electroencephalograms showed no epileptiform discharges in 33 of 41 (80%) patients, and burst suppression pattern was achieved in 29 of 41 patients (71%). RSE/SRSE was finally terminated after treatment with isoflurane in 23 of 45 patients (51%) for the entire group and in 13 of 45 patients (29%) without additional therapy. Lengths of stay in the hospital and in the neuro-ICU were significantly extended in cases of ongoing status epilepticus under isoflurane treatment (p = 0.01 for length of stay in the hospital, p = 0.049 for length in the neuro-ICU). During isoflurane treatment, side effects were reported in 40 of 45 patients (89%) and mainly included hypotension (n = 40, 89%) and/or infection (n = 20, 44%). Whether side effects occurred did not affect the outcome at discharge. Of 22 patients with follow-up magnetic resonance imaging, 2 patients (9%) showed progressive magnetic resonance imaging alterations that were considered to be potentially associated with RSE/SRSE itself or with isoflurane therapy.
Conclusions; Isoflurane was associated with a good effect in stopping RSE/SRSE. Nevertheless, establishing remission remained difficult. Side effects were common but without effect on the outcome at discharge.
Alterations in dendritic spine numbers are linked to deficits in learning and memory. While we previously revealed that postsynaptic plasticity-related gene 1 (PRG-1) controls lysophosphatidic acid (LPA) signaling at glutamatergic synapses via presynaptic LPA receptors, we now show that PRG-1 also affects spine density and synaptic plasticity in a cell-autonomous fashion via protein phosphatase 2A (PP2A)/β1-integrin activation. PRG-1 deficiency reduces spine numbers and β1-integrin activation, alters long-term potentiation (LTP), and impairs spatial memory. The intracellular PRG-1 C terminus interacts in an LPA-dependent fashion with PP2A, thus modulating its phosphatase activity at the postsynaptic density. This results in recruitment of adhesome components src, paxillin, and talin to lipid rafts and ultimately in activation of β1-integrins. Consistent with these findings, activation of PP2A with FTY720 rescues defects in spine density and LTP of PRG-1-deficient animals. These results disclose a mechanism by which bioactive lipid signaling via PRG-1 could affect synaptic plasticity and memory formation.
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
(2016)
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
Due to an increasing awareness of the potential hazardousness of air pollutants, new laws, rules and guidelines have recently been implemented globally. In this respect, numerous studies have addressed traffic-related exposure to particulate matter using stationary technology so far. By contrast, only few studies used the advanced technology of mobile exposure analysis. The Mobile Air Quality Study (MAQS) addresses the issue of air pollutant exposure by combining advanced high-granularity spatial-temporal analysis with vehicle-mounted, person-mounted and roadside sensors. The MAQS-platform will be used by international collaborators in order 1) to assess air pollutant exposure in relation to road structure, 2) to assess air pollutant exposure in relation to traffic density, 3) to assess air pollutant exposure in relation to weather conditions, 4) to compare exposure within vehicles between front and back seat (children) positions, and 5) to evaluate "traffic zone"- exposure in relation to non-"traffic zone"-exposure. Primarily, the MAQS-platform will focus on particulate matter. With the establishment of advanced mobile analysis tools, it is planed to extend the analysis to other pollutants including including NO2, SO2, nanoparticles, and ozone.