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The article deals with the so-called Musenhof of Weimar and highlights the outstanding figures who worked and lived at this artist’s court. The central role of the two «Dioscuri» Goethe and Schiller is highlighted and analyzed their initially tense relationship. The role of Herder as a writer is critically examined. Today, too, largely forgotten names are spoken of, which at that time occupied important functions at the court of Princess Amalia. It opens a wide field of further discussion in this area of research.
This article addresses a little known poem by Goethe, Planetentanz (Dance of the Planets) and analyses it’s content referring to mythology, astronomy and dramaturgy. Goethe’s planets are defined by the character of their namesake gods and goddesses as well as by the physical characters of the rocky or gaseous heavenly bodies known today with their characteristics explored by Goethe’s contemporaries. It has been shown that Goethe corresponded with some of the most influential astronomers of his time.
Tumor cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface, where it can be recognized by pre‐activated NK cells. In our retrospective study the expression of Hsp70 was determined in relation to tumor‐infiltrating CD56+ NK cells in formalin‐fixed paraffin embedded (FFPE) tumor specimens of patients with SCCHN (N = 145) as potential indicators for survival and disease recurrence. All patients received radical surgery and postoperative cisplatin‐based radiochemotherapy (RCT). In general, Hsp70 expression was stronger, but with variable intensities, in tumor compared to normal tissues. Patients with high Hsp70 expressing tumors (scores 3–4) showed significantly decreased overall survival (OS; p = 0.008), local progression‐free survival (LPFS; p = 0.034) and distant metastases‐free survival (DMFS; p = 0.044), compared to those with low Hsp70 expression (scores 0–2), which remained significant after adjustment for relevant prognostic variables. The adverse prognostic value of a high Hsp70 expression for OS was also observed in patient cohorts with p16‐ (p = 0.001), p53‐ (p = 0.0003) and HPV16 DNA‐negative (p = 0.001) tumors. The absence or low numbers of tumor‐infiltrating CD56+ NK cells also correlated with significantly decreased OS (p = 0.0001), LPFS (p = 0.0009) and DMFS (p = 0.0001). A high Hsp70 expression and low numbers of tumor‐infiltrating NK cells have the highest negative predictive value (p = 0.00004). In summary, a strong Hsp70 expression and low numbers of tumor‐infiltrating NK cells correlate with unfavorable outcome following surgery and RCT in patients with SCCHN, and thus serve as negative prognostic markers.