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Institute
The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification
(2019)
Wells, Carrow I. ; Al-Ali, Hassan ; Andrews, David M. ; Asquith, Christopher R. M. ; Axtman, Alison D. ; Chung, Mirra ; Đikić, Ivan ; Ebner, Daniel ; Elkins, Jonathan M. ; Ettmayer, Peter ; Fischer, Christian ; Frederiksen, Mathias ; Gray, Nathanael S. ; Hatch, Stephanie ; Knapp, Stefan ; Lee, Shudong ; Lücking, Ulrich ; Michaelides, Michael ; Mills, Caitlin E. ; Müller, Susanne ; Owen, Dafydd R. ; Picado, Alfredo ; Ramadan, Kristijan ; Saikatendu, Kumar S. ; Schröder, Martin ; Stolz, Alexandra ; Tellechea, Mariana ; Treiber, Daniel K. ; Turunen, Brandon J. ; Vilar, Santiago ; Wang, Jinhua ; Zuercher, William J. ; Willson, Timothy M. ; Drewry, David H.
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS) is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.