Refine
Year of publication
Document Type
- Article (39)
- Book (2)
- Conference Proceeding (2)
- Preprint (2)
Has Fulltext
- yes (45)
Is part of the Bibliography
- no (45)
Keywords
- Diagnostik (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- Früherkennung (2)
- Mammakarzinom (2)
- Nachsorge (2)
- Richtlinie (2)
- breast cancer (2)
- diagnosis (2)
- follow‑up (2)
- guideline (2)
- screening (2)
- ALK-rearranged NSCLC (1)
- AML (1)
- APRI (1)
- Acute myeloid leukemia (1)
- Antibiotic steward-ship (1)
- Antibiotics (1)
- Autorschaft (1)
- BFIS (1)
- Bleeding (1)
- CDI (1)
- CT (1)
- CVID (1)
- Chemotherapy (1)
- Cleanliness level (1)
- Colon capsule endoscopy (1)
- Complementation rate (1)
- DYT1 (1)
- Death rates (1)
- Dopamine (1)
- ESBL (1)
- Early goal-directed therapy (1)
- Enterobacteriaceae (1)
- European Society for Immunodeficiencies (ESID) (1)
- Evidence-based guidelines (1)
- FIB-4 (1)
- Fevers (1)
- Fibrotest (1)
- German PID-NET registry (1)
- HBV (1)
- HCV (1)
- HIV (1)
- Heavy Ion Experiments (1)
- Hepatocellular carcinoma (1)
- Hepatotoxicity (1)
- Hospitals (1)
- INR (1)
- IgG substitution therapy (1)
- Incomplete colonoscopy (1)
- Induction chemotherapy (1)
- Infection (1)
- Intensive care unit (1)
- International normalized ratio (1)
- Inverse kinematics (1)
- Isoscalar giant resonances (1)
- LFP (1)
- Literarischer Stil (1)
- Literaturwissenschaft (1)
- Liver cancer (1)
- Liver cirrhosis (1)
- Liver enzymes (1)
- Low volume prep (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Mortality (1)
- Moviprep (1)
- Multidrug-resistant organisms (1)
- Neutropenia (1)
- PID prevalence (1)
- PKD (1)
- PKD/IC (1)
- PRRT2 (1)
- Phospho-soda (1)
- PillCamColon2 (1)
- Point-of-care testing (1)
- Polyps (1)
- Psoriasis vulgaris (1)
- Sepsis-bundle (1)
- Storage ring (1)
- Survival (1)
- TOR1A (1)
- TP53 mutation status (1)
- Transient elastography (1)
- Treatment (1)
- Two-hit hypothesis (1)
- VRE (1)
- acoustic radiation force impulse imaging (1)
- adenocarcinoma (1)
- axions (1)
- cART (1)
- co-infection (1)
- computed tomography (1)
- critical care unit (1)
- critical ill patients (1)
- dark matter experiments (1)
- direct-acting antivirals (1)
- familial infantile epilepsy (1)
- fibrotest (1)
- hemiplegic migraine (1)
- hepatic fibrosis (1)
- hepatitis C virus (1)
- insulin resistance (1)
- interferon regulatory factor 9 (IRF9) (1)
- lung cancer (1)
- mechanical accuracy (1)
- non-invasive fibrosis assessment (1)
- phantom study (1)
- phenotypic spectrum (1)
- point shear wave elastography (1)
- primary immunodeficiency (PID) (1)
- registry for primary immunodeficiency (1)
- robot-guided stereotaxy (1)
- sepsis (1)
- sequential ALK-inhibitor therapy (1)
- solar physics (1)
- stereotactic frame (1)
- stereotactic neurosurgery (1)
- transient elastography (1)
- tumor microenvironment (TME) (1)
- type I interferons (IFNs) (1)
- versican (VCAN) (1)
- white and brown dwarfs (1)
Institute
- Medizin (25)
- Physik (9)
- Frankfurt Institute for Advanced Studies (FIAS) (7)
- Informatik (4)
- Biochemie und Chemie (2)
- Biochemie, Chemie und Pharmazie (2)
- Extern (2)
- Informatik und Mathematik (2)
- MPI für Biophysik (2)
- ELEMENTS (1)
Objective: Nationwide data on the epidemiology, treatment characteristics, and long-term outcome of severe traumatic brain injury (TBI) in Germany is not yet existing. Neurosurgeons from the German Neurosurgery Society (DGNC) and traumatologists from the German Trauma Society (DGU), therefore, joined forces in 2016 to conceptualize a TBI module for the well-established Trauma Register of the DGU (TR-DGU). Here, we report how this “German National TBI registry (GNTR)” has been developed, implemented, and tested in a recently completed pilot period.
Methods: The conception and implementation process of the GNTR from August 2016 to February 2019 is described, and results of its 23-months long pilot period from February 2019 to December 2020 are presented. For the pilot period, TBI patients were prospectively enrolled at nine neurosurgical and traumatological hospitals across Germany. Inclusion criteria were treatment on the ICU ≥ 24h, or an ISS score ≥ 16. A variety of clinical, imaging, and laboratory parameters were collected, and the GOSE score was used to assess the outcome at discharge and 6- and 12 months follow-up.
Results: Details on the structure and dataset of the GNTR as well as milestones and pitfalls during its conception and implementation, are outlined. During the pilot period, a total of 264 TBI patients were enrolled. Their demographic characteristics, clinical, imaging, and radiological findings, and their early mortality and functional outcome are described. Furthermore, factors associated with an unfavorable outcome (GOSE 1-4) are assessed using uni- and multivariate regression analyses. Finally, problems and future directions of the GNTR are discussed.
Conclusion: The pilot period of the GNTR offers a first glance at the current epidemiology and treatment characteristics of TBI patients in Germany. More importantly, they show how a national TBI registry yielding high-quality prospective data can be developed, implemented, and tested within four years
Background: The development of robotic systems has provided an alternative to frame-based stereotactic procedures. The aim of this experimental phantom study was to compare the mechanical accuracy of the Robotic Surgery Assistant (ROSA) and the Leksell stereotactic frame by reducing clinical and procedural factors to a minimum.
Methods: To precisely compare mechanical accuracy, a stereotactic system was chosen as reference for both methods. A thin layer CT scan with an acrylic phantom fixed to the frame and a localizer enabling the software to recognize the coordinate system was performed. For each of the five phantom targets, two different trajectories were planned, resulting in 10 trajectories. A series of five repetitions was performed, each time based on a new CT scan. Hence, 50 trajectories were analyzed for each method. X-rays of the final cannula position were fused with the planning data. The coordinates of the target point and the endpoint of the robot- or frame-guided probe were visually determined using the robotic software. The target point error (TPE) was calculated applying the Euclidian distance. The depth deviation along the trajectory and the lateral deviation were separately calculated.
Results: Robotics was significantly more accurate, with an arithmetic TPE mean of 0.53 mm (95% CI 0.41–0.55 mm) compared to 0.72 mm (95% CI 0.63–0.8 mm) in stereotaxy (p < 0.05). In robotics, the mean depth deviation along the trajectory was −0.22 mm (95% CI −0.25 to −0.14 mm). The mean lateral deviation was 0.43 mm (95% CI 0.32–0.49 mm). In frame-based stereotaxy, the mean depth deviation amounted to −0.20 mm (95% CI −0.26 to −0.14 mm), the mean lateral deviation to 0.65 mm (95% CI 0.55–0.74 mm).
Conclusion: Both the robotic and frame-based approach proved accurate. The robotic procedure showed significantly higher accuracy. For both methods, procedural factors occurring during surgery might have a more relevant impact on overall accuracy.
A new technique developed for measuring nuclear reactions at low momentum transfer with stored beams in inverse kinematics was successfully used to study isoscalar giant resonances. The experiment was carried out at the experimental heavy-ion storage ring (ESR) at the GSI facility using a stored 58Ni beam at 100 MeV/u and an internal helium gas-jet target. In these measurements, inelastically scattered α-recoils at very forward center-of-mass angles (θcm ≤ 1.5°) were detected with a dedicated setup, including ultra-high vacuum compatible detectors. Experimental results indicate a dominant contribution of the isoscalar giant monopole resonance at this very forward angular range. It was found that the monopole contribution exhausts 79+12−11% of the energy-weighted sum rule (EWSR), which agrees with measurements performed in normal kinematics. This opens up the opportunity to investigate the giant resonances in a large domain of unstable and exotic nuclei in the near future. It is a fundamental milestone towards new nuclear reaction studies with stored ion beams.
Pathogenic variants in PRRT2, encoding the proline-rich transmembrane protein 2, have been associated with an evolving spectrum of paroxysmal neurologic disorders. Based on a cohort of children with PRRT2-related infantile epilepsy, this study aimed at delineating the broad clinical spectrum of PRRT2-associated phenotypes in these children and their relatives. Only a few recent larger cohort studies are on record and findings from single reports were not confirmed so far. We collected detailed genetic and phenotypic data of 40 previously unreported patients from 36 families. All patients had benign infantile epilepsy and harbored pathogenic variants in PRRT2 (core cohort). Clinical data of 62 family members were included, comprising a cohort of 102 individuals (extended cohort) with PRRT2-associated neurological disease. Additional phenotypes in the cohort of patients with benign sporadic and familial infantile epilepsy consist of movement disorders with paroxysmal kinesigenic dyskinesia in six patients, infantile-onset movement disorders in 2 of 40 individuals, and episodic ataxia after mild head trauma in one girl with bi-allelic variants in PRRT2. The same girl displayed a focal cortical dysplasia upon brain imaging. Familial hemiplegic migraine and migraine with aura were reported in nine families. A single individual developed epilepsy with continuous spikes and waves during sleep. In addition to known variants, we report the novel variant c.843G>T, p.(Trp281Cys) that co-segregated with benign infantile epilepsy and migraine in one family. Our study highlights the variability of clinical presentations of patients harboring pathogenic PRRT2 variants and expands the associated phenotypic spectrum.