Refine
Year of publication
Document Type
- Preprint (576)
- Article (398)
- Conference Proceeding (7)
- Working Paper (4)
- Book (1)
- Part of a Book (1)
Has Fulltext
- yes (987)
Is part of the Bibliography
- no (987)
Keywords
- Heavy Ion Experiments (18)
- Hadron-Hadron scattering (experiments) (11)
- LHC (9)
- Heavy-ion collision (6)
- ALICE experiment (4)
- Hadron-Hadron Scattering (4)
- Heavy Ions (4)
- Quark-Gluon Plasma (4)
- ALICE (3)
- Jets and Jet Substructure (3)
- glioblastoma (3)
- pp collisions (3)
- Acute myeloid leukemia (2)
- Beauty production (2)
- Charm physics (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- HOD (2)
- Induction chemotherapy (2)
- Intensive care treatment (2)
- Jets (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- Polymers (2)
- Single electrons (2)
- Survival (2)
- glioma (2)
- resilience (2)
- 900 GeV (1)
- ACLF (1)
- ALICE detector (1)
- AML (1)
- ASCT (1)
- ATR-FTIR (1)
- Abundance (1)
- Acute kidney failure (1)
- Alzheimer’s dementia (1)
- Amyloid-beta 42 (1)
- Analysis and statistical methods (1)
- Anti-kaon–nucleon physics (1)
- Anti-nuclei (1)
- Aphasia (1)
- Aphasie (1)
- Arcuate fascicle (1)
- Atomic and Molecular Physics (1)
- Autecology (1)
- BRAF (1)
- BRAF V600E (1)
- Baryonic resonances (1)
- Biomarkers (1)
- Bone marrow aspiration (1)
- Brain metastasis (1)
- Brain tumor (1)
- Breast cancer (1)
- CBC (1)
- CHIP (1)
- CLOUD experiment (1)
- CMS (1)
- CVID (1)
- Calorimeters (1)
- Cancer treatment (1)
- Centrality Class (1)
- Centrality Selection (1)
- Chemistry (1)
- Collective Flow (1)
- Comparison with QCD (1)
- Data processing methods (1)
- Ecology (1)
- Ecotoxicology (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Ellenberg indicator values (1)
- Elliptic flow (1)
- Environmental quality (1)
- Environmental sciences (1)
- European Society for Immunodeficiencies (ESID) (1)
- Fasciculus arcuatus (1)
- Feeding types (1)
- Femtoscopy (1)
- Festuco-Brometea (1)
- Fibre/foam sandwich radiator (1)
- Fluid overload (1)
- Freezeout (1)
- Freshwater (1)
- German PID-NET registry (1)
- Glioma (1)
- HBT (1)
- HVPG (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Heavy Ion Experiment (1)
- Heavy Quark Production (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Heavy-ion reactions (1)
- Hippocampal volume (1)
- Hirninfarkt (1)
- Holmes tremor (1)
- Hyperons (1)
- IgG substitution therapy (1)
- Imidacloprid (1)
- Inclusive spectra (1)
- Intensity interferometry (1)
- Invariant Mass Distribution (1)
- Invertebrates (1)
- Ionisation energy loss (1)
- Ischemic stroke (1)
- Kaonic nuclei (1)
- Kollisionen schwerer Ionen (1)
- Lacunar (1)
- Lakunär (1)
- Lesions (1)
- Litter (1)
- Low energy QCD (1)
- MRI (1)
- Microplastic-biota interaction (1)
- Microplastics (1)
- Mid-rapidity (1)
- Mild cognitive impairment (1)
- Minimum Bias (1)
- Molecular matched therapy (1)
- Molecular profiling (1)
- Monitoring (1)
- Monte Carlo (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Multiple stressors (1)
- Nanoplastics (1)
- Necrosis (1)
- Neural network (1)
- Non-small cell lung cancer (1)
- Nuclear modification factor (1)
- Nucleus (1)
- PID prevalence (1)
- PXA (1)
- PYTHIA (1)
- Partial wave analysis (1)
- Particle Correlations and Fluctuations (1)
- Pb–Pb (1)
- Performance of High Energy Physics Detectors (1)
- Peripheral blood smears (1)
- Phospho-tau (1)
- Plastic polymers (1)
- Plastics (1)
- Prediction (1)
- Production Cross Section (1)
- Properties of Hadrons (1)
- Proton (1)
- Proton–proton (1)
- Pyrolysis GC–MS (1)
- QCD (1)
- QMD (1)
- Quantenmolekulardynamik (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Rapidity Range (1)
- Relapse surveillance (1)
- Relativistic heavy ion physics (1)
- Relativistic heavy-ion collisions (1)
- Resolution Parameter (1)
- Review (1)
- Single muons (1)
- Stereotactic radiosurgery (1)
- Strangeness (1)
- Subcortical (1)
- Subkortikal (1)
- Suspended solids (1)
- Systematic Uncertainty (1)
- TR (1)
- Targeted therapy (1)
- Tau (1)
- Thermal desorption GC–MS (1)
- Time Projection Chamber (1)
- Toxicity (1)
- Tracking (1)
- Transition radiation detector (1)
- Transverse momentum (1)
- Trigger (1)
- Vector (1)
- Vector Boson Production (1)
- Visual analysis (1)
- Water framework directive (1)
- Xenon-based gas mixture (1)
- acute decompensation (1)
- aerosol formation (1)
- aerosols (1)
- anti-angiogenic therapy (1)
- asset pricing (1)
- autologous stem cell transplantation (1)
- bevacizumab (1)
- cerebellar mutism (1)
- cerebellum (1)
- chemotherapy (1)
- cirrhosis (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- cortex, gray matter (1)
- credit risk (1)
- dE/dx (1)
- dabrafenib (1)
- diffusion tensor imaging (1)
- dispersal (1)
- ecological strategy (1)
- equity options (1)
- fractional anisotropy (1)
- gliomatosis cerebri growth pattern (1)
- heavy ion collisions (1)
- heavy ion experiments (1)
- hematopoietic stem cells (1)
- hematopoietic stress (1)
- hydrocephalus (1)
- hypoxia (1)
- intestinal manipulation (1)
- intraventricular chemotherapy (1)
- isolation (1)
- leptomeningeal disease (1)
- leptomeningeal metastases (1)
- leukemia (1)
- low risk anomaly (1)
- mean diffusivity (1)
- medulloblastoma (1)
- medulloblastoma resection (1)
- mowing (1)
- multiple sclerosis (1)
- nanoparticle growth (1)
- naturalness (1)
- neurosurgery (1)
- palatal tremor (1)
- pandemics (1)
- patterns of progression (1)
- perioperative ischemia (1)
- phenology (1)
- plant traits (1)
- pleomorphic xanthoastrocytoma (1)
- portal pressure (1)
- posterior fossa masses (1)
- ppK − (1)
- primary brain tumors (1)
- primary immunodeficiency (PID) (1)
- quant molekular dynamic (1)
- quark gluon plasma (1)
- rare disasters (1)
- registry for primary immunodeficiency (1)
- risk premia (1)
- skewness (1)
- social distance (1)
- somatic mutations (1)
- spectra (1)
- surgery (1)
- ventriculoperitoneal shunt (1)
- volatile organic compounds (1)
- √sN N = 2.76 TeV (1)
Institute
Hintergrund: Aphasien gehören nicht zu den typischen klinischen Manifestationen lakunärer Hirninfarkte, sind jedoch im Rahmen seltener atypischer lakunärer Syndrome beschrieben.
Ziel der Arbeit: Beschreibung von Aphasiemustern und betroffener Fasertrakte bei lakunären Infarkten.
Material und Methoden: Fallserie von drei Patienten mit in der Magnetresonanztomographie nachgewiesenen lakunären Hirninfarkten und Aphasie. Identifikation betroffener Faserbahnen mittels Fasertraktographie der koregistrierten Schädigungsorte in Gehirnen zweier gesunder Probanden.
Ergebnisse: Radiologisch waren die Lakunen, die Aphasien hervorriefen, weit lateral im Marklager der linken Hemisphäre gelegen und befanden sich im Vergleich zu der Lakune eines nichtaphasischen Kontrollpatienten weiter rostrodorsal. Klinisch fand sich trotz Aussparung des Kortex, Thalamus und weiter Teile der Basalganglien eine leichte bis moderate nichtflüssige Aphasie mit syntaktischen Defiziten. In der Fasertraktographie zeigten die aphasischen im Vergleich zum nichtaphasischen Patienten eine stärkere Affektion der Fasern des linken Fasciculus arcuatus sowie eine Beteiligung des frontostriatalen und frontalen Aslant-Trakts.
Diskussion: Links lateral gelegene lakunäre Infarkte können durch Beteiligung sprachrelevanter Fasertrakte eine klinisch relevante Aphasie hervorrufen.
Purpose: Stereotactic radiosurgery (SRS) is an established primary treatment for newly diagnosed brain metastases with high local control rates. However, data about local re-irradiation in case of local failure after SRS (re-SRS) are rare. We evaluated the feasibility, efficacy and patient selection characteristics in treating locally recurrent metastases with a second course of SRS.
Methods: We retrospectively evaluated patients with brain metastases treated with re-SRS for local tumor progression between 2011 and 2017. Patient and treatment characteristics as well as rates of tumor control, survival and toxicity were analyzed.
Results: Overall, 32 locally recurrent brain metastases in 31 patients were irradiated with re-SRS. Median age at re-SRS was 64.9 years. The primary histology was breast cancer and non-small-cellular lung cancer (NSCLC) in respectively 10 cases (31.3%), in 5 cases malignant melanoma (15.6%). In the first SRS-course 19 metastases (59.4%) and in the re-SRS-course 29 metastases (90.6%) were treated with CyberKnife® and the others with Gamma Knife. Median planning target volume (PTV) for re-SRS was 2.5 cm3 (range, 0.1–37.5 cm3) and median dose prescribed to the PTV was 19 Gy (range, 12–28 Gy) in 1–5 fractions to the median 69% isodose (range, 53–80%). The 1-year overall survival rate was 61.7% and the 1-year local control rate was 79.5%. The overall rate of radiological radio-necrosis was 16.1% and four patients (12.9%) experienced grade ≥ 3 toxicities.
Conclusions: A second course of SRS for locally recurrent brain metastases after prior local SRS appears to be feasible with acceptable toxicity and can be considered as salvage treatment option for selected patients with high performance status. Furthermore, this is the first study utilizing robotic radiosurgery for this indication, as an additional option for frameless fractionated treatment.
Bevacizumab for patients with recurrent gliomas presenting with a gliomatosis cerebri growth pattern
(2017)
Bevacizumab has been shown to improve progression-free survival and neurologic function, but failed to improve overall survival in newly diagnosed glioblastoma and at first recurrence. Nonetheless, bevacizumab is widely used in patients with recurrent glioma. However, its use in patients with gliomas showing a gliomatosis cerebri growth pattern is contentious. Due to the marked diffuse and infiltrative growth with less angiogenic tumor growth, it may appear questionable whether bevacizumab can have a therapeutic effect in those patients. However, the development of nodular, necrotic, and/or contrast-enhancing lesions in patients with a gliomatosis cerebri growth pattern is not uncommon and may indicate focal neo-angiogenesis. Therefore, control of growth of these lesions as well as control of edema and reduction of steroid use may be regarded as rationales for the use of bevacizumab in these patients. In this retrospective patient series, we report on 17 patients with primary brain tumors displaying a gliomatosis cerebri growth pattern (including seven glioblastomas, two anaplastic astrocytomas, one anaplastic oligodendroglioma, and seven diffuse astrocytomas). Patients have been treated with bevacizumab alone or in combination with lomustine or irinotecan. Seventeen matched patients treated with bevacizumab for gliomas with a classical growth pattern served as a control cohort. Response rate, progression-free survival, and overall survival were similar in both groups. Based on these results, anti-angiogenic therapy with bevacizumab should also be considered in patients suffering from gliomas with a mainly infiltrative phenotype.
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the circulatory system. Inflammation and mortality risk markers were previously detected in COVID-19 plasma and red blood cells (RBCs) metabolic and proteomic profiles. Additionally, biophysical properties, such as deformability, were found to be changed during the infection. Based on such data, we aim to better characterize RBC functions in COVID-19. We evaluate the flow properties of RBCs in severe COVID-19 patients admitted to the intensive care unit by using in vitro microfluidic techniques and automated methods, including artificial neural networks, for an unbiased RBC analysis. We find strong flow and RBC shape impairment in COVID-19 samples and demonstrate that such changes are reversible upon suspension of COVID-19 RBCs in healthy plasma. Vice versa, healthy RBCs immediately resemble COVID-19 RBCs when suspended in COVID-19 plasma. Proteomics and metabolomics analyses allow us to detect the effect of plasma exchanges on both plasma and RBCs and demonstrate a new role of RBCs in maintaining plasma equilibria at the expense of their flow properties. Our findings provide a framework for further investigations of clinical relevance for therapies against COVID-19 and possibly other infectious diseases.
The toxicity of microplastics on Daphnia magna as a key model for freshwater zooplankton is well described. While several studies predict population-level effects based on short-term, individual-level responses, only very few have validated these predictions experimentally. Thus, we exposed D. magna populations to irregular polystyrene microplastics and diatomite as natural particle (both ≤ 63 μm) over 50 days. We used mixtures of both particle types at fixed particle concentrations (50,000 particles mL-1) and recorded the effects on overall population size and structure, the size of the individual animals, and resting egg production. Particle exposure adversely affected the population size and structure and induced resting egg production. The terminal population size was 28–42% lower in exposed compared to control populations. Interestingly, mixtures containing diatomite induced stronger effects than microplastics alone, highlighting that natural particles are not per se less toxic than microplastics. Our results demonstrate that an exposure to synthetic and natural particles has negative population-level effects on zooplankton. Understanding the mixture toxicity of microplastics and natural particles is important given that aquatic organisms will experience exposure to both. Just as for chemical pollutants, better knowledge of such joint effects is essential to fully understand the environmental impacts of complex particle mixtures.
Environmental Implications While microplastics are commonly considered hazardous based on individual-level effects, there is a dearth of information on how they affect populations. Since the latter is key for understanding the environmental impacts of microplastics, we investigated how particle exposures affect the population size and structure of Daphnia magna. In addition, we used mixtures of microplastics and natural particles because neither occurs alone in nature and joint effects can be expected in an environmentally realistic scenario. We show that such mixtures adversely affect daphnid populations and highlight that population-level and mixture-toxicity designs are one important step towards more environmental realism in microplastics research.
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the circulatory system. Inflammation and mortality risk markers were previously detected in COVID-19 plasma and red blood cells (RBCs) metabolic and proteomic profiles. Additionally, biophysical properties, such as deformability, were found to be changed during the infection. Based on such data, we aim to better characterize RBC functions in COVID-19. We evaluate the flow properties of RBCs in severe COVID-19 patients admitted to the intensive care unit by using in vitro microfluidic techniques and automated methods, including artificial neural networks, for an unbiased RBC analysis. We find strong flow and RBC shape impairment in COVID-19 samples and demonstrate that such changes are reversible upon suspension of COVID-19 RBCs in healthy plasma. Vice versa, healthy RBCs immediately resemble COVID-19 RBCs when suspended in COVID-19 plasma. Proteomics and metabolomics analyses allow us to detect the effect of plasma exchanges on both plasma and RBCs and demonstrate a new role of RBCs in maintaining plasma equilibria at the expense of their flow properties. Our findings provide a framework for further investigations of clinical relevance for therapies against COVID-19 and possibly other infectious diseases.
We measured the Coulomb dissociation of 16O into 4He and 12C at the R3B setup in a first campaign within FAIR Phase 0 at GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt. The goal was to improve the accuracy of the experimental data for the 12C(α,γ)16O fusion reaction and to reach lower center-ofmass energies than measured so far.
The experiment required beam intensities of 109 16O ions per second at an energy of 500 MeV/nucleon. The rare case of Coulomb breakup into 12C and 4He posed another challenge: The magnetic rigidities of the particles are so close because of the same mass-to-charge-number ratio A/Z = 2 for 16O, 12C and 4He. Hence, radical changes of the R3B setup were necessary. All detectors had slits to allow the passage of the unreacted 16O ions, while 4He and 12C would hit the detectors' active areas depending on the scattering angle and their relative energies. We developed and built detectors based on organic scintillators to track and identify the reaction products with sufficient precision.