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The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Members of the genus Xenorhabdus are entomopathogenic bacteria that associate with nematodes. The nematode-bacteria pair infects and kills insects, with both partners contributing to insect pathogenesis and the bacteria providing nutrition to the nematode from available insect-derived nutrients. The nematode provides the bacteria with protection from predators, access to nutrients, and a mechanism of dispersal. Members of the bacterial genus Photorhabdus also associate with nematodes to kill insects, and both genera of bacteria provide similar services to their different nematode hosts through unique physiological and metabolic mechanisms. We posited that these differences would be reflected in their respective genomes. To test this, we sequenced to completion the genomes of Xenorhabdus nematophila ATCC 19061 and Xenorhabdus bovienii SS-2004. As expected, both Xenorhabdus genomes encode many anti-insecticidal compounds, commensurate with their entomopathogenic lifestyle. Despite the similarities in lifestyle between Xenorhabdus and Photorhabdus bacteria, a comparative analysis of the Xenorhabdus, Photorhabdus luminescens, and P. asymbiotica genomes suggests genomic divergence. These findings indicate that evolutionary changes shaped by symbiotic interactions can follow different routes to achieve similar end points.
To date, only two references place members of the genus Diplocentrus in Sonora, Mexico. The first was a passing comment by Francke (1975) that D. spitzeri Stahnke occurs in northeastern Sonora. The specimens he examined and used in his systematic studies on that species are the same as the ones reported here for the first time from a specific Sonoran locality. The second reference was by Sissom and Walker (1992) listing a single record of D. gertschi Sissom and Walker from Libertad on the northern coast. Examination of material from the American Museum of Natural History (AMNH), the California Academy of Sciences (CAS), and the Academy of Natural Sciences (ANS) indicates that, in addition to D. spitzeri and D. gertschi, another distinct species occurs in the Alamos and Navajoa areas in southern Sonora. This species is described as new below. It should be noted that a juvenile specimen from the vicinity of Benjamin Hill was also examined that was unassignable with certainty to any of the above species. This indicates that the genus has a wider distribution in Sonora than demonstrated even by the specimens listed in this report. Nomenclature and mensuration utilized herein essentially follows that of Stahnke (1970), with the following exceptions: carinal terminology and cheliceral measurements are after Francke (1975,1977) and trichobothrial terminology is after Vachon (1974). Specimens in the senior author's collection are listed in the records sections as "WDS”. Because D. spitzeri and the new species are both quite similar to D. peloncil1ensis Francke, the latter is included in the tables for comparison; in addition, the hemispermatophore of this species is also drawn. D. peloncillensis was described from only 6 males, 1 female, and 1 juvenile. The data presented here for D. peloncillensis are derived from these and new specimens available since the original description was published (Francke 1975), thereby providing a better understanding of variation in this species.