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The Quark Gluon Plasma (QGP) produced in ultra relativistic heavy-ion collisions at the Large Hadron Collider (LHC) can be studied by measuring the modifications of jets formed by hard scattered partons which interact with the medium. We studied these modifications via angular correlations of jets with charged hadrons for jets with momenta 20 < pjetT < 40 GeV/c as a function of the associated particle momentum. The reaction plane fit (RPF) method is used in this analysis to remove the flow modulated background. The analysis of angular correlations for different orientations of the jet relative to the second order event plane allows for the study of the path length dependence of medium modifications to jets. We present the dependence of azimuthal angular correlations of charged hadrons with respect to the angle of the axis of a reconstructed jet relative to the event plane in Pb-Pb collisions at sNN−−−√ = 2.76 TeV. The dependence of particle yields associated with jets on the angle of the jet with respect to the event plane is presented. Correlations at different angles relative to the event plane are compared through ratios and differences of the yield. No dependence of the results on the angle of the jet with respect to the event plane is observed within uncertainties, which is consistent with no significant path length dependence of the medium modifications for this observable.
The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined.
The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the LHC are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined.
Measurements of K∗(892)0 and ϕ(1020) resonance production in Pb-Pb and pp collisions at sNN−−−√ = 5.02 TeV with the ALICE detector at the Large Hadron Collider are reported. The resonances are measured at midrapidity (|y| < 0.5) via their hadronic decay channels and the transverse momentum (pT) distributions are obtained for various collision centrality classes up to pT = 20 GeV/c. The pT-integrated yield ratio K∗(892)0/K in Pb-Pb collisions shows significant suppression relative to pp collisions and decreases towards more central collisions. In contrast, the ϕ(1020)/K ratio does not show any suppression. Furthermore, the measured K∗(892)0/K ratio in central Pb-Pb collisions is significantly suppressed with respect to the expectations based on a thermal model calculation, while the ϕ(1020)/K ratio agrees with the model prediction. These measurements are an experimental demonstration of rescattering of K∗(892)0 decay products in the hadronic phase of the collisions. The K∗(892)0/K yield ratios in Pb-Pb and pp collisions are used to estimate the time duration between chemical and kinetic freeze-out, which is found to be ∼ 4-7 fm/c for central collisions. The pT-differential ratios of K∗(892)0/K, ϕ(1020)/K, K∗(892)0/π, ϕ(1020)/π, p/K∗(892)0 and p/ϕ(1020) are also presented for Pb-Pb and pp collisions at sNN−−−√ = 5.02 TeV. These ratios show that the rescattering effect is predominantly a low-pT phenomenon.
Measurements of K∗(892)0 and ϕ(1020) resonance production in Pb-Pb and pp collisions at sNN−−−√ = 5.02 TeV with the ALICE detector at the Large Hadron Collider are reported. The resonances are measured at midrapidity (|y| < 0.5) via their hadronic decay channels and the transverse momentum (pT) distributions are obtained for various collision centrality classes up to pT = 20 GeV/c. The pT-integrated yield ratio K∗(892)0/K in Pb-Pb collisions shows significant suppression relative to pp collisions and decreases towards more central collisions. In contrast, the ϕ(1020)/K ratio does not show any suppression. Furthermore, the measured K∗(892)0/K ratio in central Pb-Pb collisions is significantly suppressed with respect to the expectations based on a thermal model calculation, while the ϕ(1020)/K ratio agrees with the model prediction. These measurements are an experimental demonstration of rescattering of K∗(892)0 decay products in the hadronic phase of the collisions. The K∗(892)0/K yield ratios in Pb-Pb and pp collisions are used to estimate the time duration between chemical and kinetic freeze-out, which is found to be ∼ 4-7 fm/c for central collisions. The pT-differential ratios of K∗(892)0/K, ϕ(1020)/K, K∗(892)0/π, ϕ(1020)/π, p/K∗(892)0 and p/ϕ(1020) are also presented for Pb-Pb and pp collisions at sNN−−−√ = 5.02 TeV. These ratios show that the rescattering effect is predominantly a low-pT phenomenon.
The first measurement at the LHC of charge-dependent directed flow (v1) relative to the spectator plane is presented for Pb-Pb collisions at sNN−−−√ = 5.02 TeV. Results are reported for charged hadrons and D0 mesons for the transverse momentum intervals pT>0.2 GeV/c and 3<pT< 6 GeV/c in the 5-40% and 10-40% centrality classes, respectively. The difference between the positively and negatively charged hadron v1 is found to have a positive slope as a function of pseudorapidity η, dΔv1/dη=[1.68 ± 0.49 (stat.) ± 0.41 (syst.)] ×10−4, with a 2.6σ significance. The same measurement for D0 and D¯0 mesons yields a positive value dΔv1/dη= [4.9 ± 1.7 (stat.) ± 0.6 (syst.)]×10−1, which is about three orders of magnitude larger than the one of the charged hadrons, and is larger than zero with significance of 2.7σ. These measurements can provide new insights into the effects of the strong electromagnetic field and the initial tilt of matter created in non-central heavy-ion collisions on the dynamics of light (u, d, and s) and heavy (c) quarks. The large difference between the observed Δv1 of charged hadrons and D0 mesons may reflect different sensitivity of the charm and light quarks to the early time dynamics of a heavy-ion collision. These observations challenge some of the recent theoretical calculations incorporating effects of the strong electromagnetic field, which predicted a negative and an order of magnitude smaller value of dΔv1/dη for both light-flavour and charmed hadrons.
Υ production in p-Pb interactions is studied at the centre-of-mass energy per nucleon-nucleon collision sNN−−−√ = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03<ycms<3.53 and −4.46<ycms<−2.96, down to zero transverse momentum. In this work, results on the inclusive Υ(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the Υ(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the Υ(2S) nuclear modification factor is also evaluated, suggesting a suppression similar to that of the Υ(1S). A first measurement of the Υ(3S) has also been performed. Finally, results are compared with previous measurements performed by ALICE in p-Pb collisions at sNN−−−√ = 5.02 TeV and with theoretical calculations.
Υ production in p-Pb interactions is studied at the centre-of-mass energy per nucleon-nucleon collision sNN−−−√ = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03<ycms<3.53 and −4.46<ycms<−2.96, down to zero transverse momentum. In this work, results on the inclusive Υ(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the Υ(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the Υ(2S) nuclear modification factor is also evaluated, suggesting a suppression similar to that of the Υ(1S). A first measurement of the Υ(3S) has also been performed. Finally, results are compared with previous measurements performed by ALICE in p-Pb collisions at sNN−−−√ = 5.02 TeV and with theoretical calculations.
Inclusive Υ production in p-Pb interactions is studied at the centre-of-mass energy per nucleon-nucleon collision sNN−−−√ = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03<ycms<3.53 and −4.46<ycms<−2.96, down to zero transverse momentum. In this work, results on the inclusive Υ(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the Υ(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. The inclusive Υ(2S) nuclear modification factor is also evaluated, suggesting a suppression similar to that of the Υ(1S). Finally, results are compared with previous measurements performed by ALICE in p-Pb collisions at sNN−−−√ = 5.02 TeV and with theoretical calculations.
Measurements of identified hadrons as a function of the charged-particle multiplicity in pp collisions enable a search for the onset of collective effects in small collision systems. With such measurements, it is possible to study the mechanisms that determine the shapes of hadron transverse momentum (pT) spectra, to search for possible modifications of the yields of short-lived hadronic resonances due to scattering effects in the hadron-gas phase, and to investigate different explanations for the multiplicity evolution of strangeness production provided by phenomenological models. In this paper, these topics are addressed through measurements of the K∗(892)0 and ϕ(1020) mesons at midrapidity in pp collisions at s√ = 13 TeV as a function of the charged-particle multiplicity. The results include the pT spectra, pT-integrated yields, mean transverse momenta, and the ratios of the yields of these resonances to those of longer-lived hadrons. Comparisons with results from other collision systems and energies, as well as predictions from phenomenological models, are also discussed.
The first evidence of spin alignment of vector mesons (K∗0 and ϕ) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The spin density matrix element ρ00 is measured at midrapidity (|y|< 0.5) in Pb-Pb collisions at a center-of-mass energy (sNN−−−√) of 2.76 TeV with the ALICE detector. ρ00 values are found to be less than 1/3 (1/3 implies no spin alignment) at low transverse momentum (pT< 2 GeV/c) for K∗0 and ϕ at a level of 3σ and 2σ, respectively. No significant spin alignment is observed for the K0S meson (spin = 0) in Pb-Pb collisions and for the vector mesons in pp collisions. The measured spin alignment is unexpectedly large but qualitatively consistent with the expectation from models which attribute it to a polarization of quarks in the presence of angular momentum in heavy-ion collisions and a subsequent hadronization by the process of recombination.
Measurement of spin-orbital angular momentum interactions in relativistic heavy-ion collisions
(2019)
The first measurement of spin alignment of vector mesons (K∗0 and ϕ) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The measurements are carried out as a function of transverse momentum (pT ) and collision centrality with the ALICE detector using the particles produced at midrapidity (|y|< 0.5) in Pb-Pb collisions at a center-of-mass energy (sNN−−−√) of 2.76 TeV. The second diagonal spin density matrix element (ρ00 ) is measured from the angular distribution of the decay daughters of the vector meson in the decay rest frame, with respect to the normal of both the event plane and the production plane. The ρ00 values are found to be less than 1/3 (= 1/3 implies no spin alignment) at low pT (< 2 GeV/c) for both vector mesons. The observed deviations from 1/3 are maximal for mid-central collisions at a level of 3σ for K∗0 and 2σ for ϕ mesons. As control measurements, the analysis is also performed using the K0S meson, which has zero spin, and for the vector mesons in pp collisions; in both cases no significant spin alignment is observed. The ρ00 values at low pT with respect to the production plane are closer to 1/3 than for the event plane; they are related to each other through correlations introduced by the elliptic flow in the system. The measured spin alignment is surprisingly large compared to the polarization measured for Λ hyperons, but qualitatively consistent with the expectation from models which attribute the spin alignment to a polarization of quarks in the presence of large initial angular momentum in non-central heavy-ion collisions and a subsequent hadronization by the process of recombination.
This article reports measurements of the pT-differential inclusive jet cross-section in pp collisions at s√ = 5.02 TeV and the pT-differential inclusive jet yield in Pb-Pb 0-10% central collisions at sNN−−−√ = 5.02 TeV. Jets were reconstructed at mid-rapidity with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm. For pp collisions, we report jet cross-sections for jet resolution parameters R=0.1−0.6 over the range 20<pT,jet<140 GeV/c, as well as the jet cross-section ratios of different R, and comparisons to two next-to-leading-order (NLO)-based theoretical predictions. For Pb-Pb collisions, we report the R=0.2 and R=0.4 jet spectra for 40<pT,jet<140 GeV/c and 60<pT,jet<140 GeV/c, respectively. The scaled ratio of jet yields observed in Pb-Pb to pp collisions, RAA, is constructed, and exhibits strong jet quenching and a clear pT-dependence for R=0.2. No significant R-dependence of the jet RAA is observed within the uncertainties of the measurement. These results are compared to several theoretical predictions.
This article reports measurements of the pT-differential inclusive jet cross-section in pp collisions at s√ = 5.02 TeV and the pT-differential inclusive jet yield in Pb-Pb 0-10% central collisions at sNN−−−√ = 5.02 TeV. Jets were reconstructed at mid-rapidity with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm. For pp collisions, we report jet cross-sections for jet resolution parameters R=0.1−0.6 over the range 20<pT,jet<140 GeV/c, as well as the jet cross-section ratios of different R, and comparisons to two next-to-leading-order (NLO)-based theoretical predictions. For Pb-Pb collisions, we report the R=0.2 and R=0.4 jet spectra for 40<pT,jet<140 GeV/c and 60<pT,jet<140 GeV/c, respectively. The scaled ratio of jet yields observed in Pb-Pb to pp collisions, RAA, is constructed, and exhibits strong jet quenching and a clear pT-dependence for R=0.2. No significant R-dependence of the jet RAA is observed within the uncertainties of the measurement. These results are compared to several theoretical predictions.
This article reports measurements of the pT-differential inclusive jet cross-section in pp collisions at s√ = 5.02 TeV and the pT-differential inclusive jet yield in Pb-Pb 0-10% central collisions at sNN−−−√ = 5.02 TeV. Jets were reconstructed at mid-rapidity with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm. For pp collisions, we report jet cross-sections for jet resolution parameters R=0.1−0.6 over the range 20<pT,jet<140 GeV/c, as well as the jet cross-section ratios of different R, and comparisons to two next-to-leading-order (NLO)-based theoretical predictions. For Pb-Pb collisions, we report the R=0.2 and R=0.4 jet spectra for 40<pT,jet<140 GeV/c and 60<pT,jet<140 GeV/c, respectively. The scaled ratio of jet yields observed in Pb-Pb to pp collisions, RAA, is constructed, and exhibits strong jet quenching and a clear pT-dependence for R=0.2. No significant R-dependence of the jet RAA is observed within the uncertainties of the measurement. These results are compared to several theoretical predictions.
The striking similarities that have been observed between high-multiplicity proton-proton (pp) collisions and heavy-ion collisions can be explored through multiplicity-differential measurements of identified hadrons in pp collisions. With these measurements, it is possible to study mechanisms such as collective flow that determine the shapes of hadron transverse momentum (pT) spectra, to search for possible modifications of the yields of short-lived hadronic resonances due to scattering effects in an extended hadron-gas phase, and to investigate different explanations provided by phenomenological models for enhancement of strangeness production with increasing multiplicity. In this paper, these topics are addressed through measurements of the K∗(892)0 and φ(1020) mesons at midrapidity in pp collisions at √s = 13 TeV as a function of the charged-particle multiplicity. The results include the pT spectra, pT-integrated yields, mean transverse momenta, and the ratios of the yields of these resonances to those of longer-lived hadrons. Comparisons with results from other collision systems and energies, as well as predictions from phenomenological models, are also discussed.
The inclusive J/ψ meson production in Pb–Pb collisions at a center-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV at midrapidity (|y|<0.9) is reported by the ALICE Collaboration. The measurements are performed in the dielectron decay channel, as a function of event centrality and J/ψ transverse momentum pT, down to pT=0. The J/ψ mean transverse momentum 〈pT〉 and rAA ratio, defined as 〈pT2〉PbPb/〈pT2〉pp, are evaluated. Both observables show a centrality dependence decreasing towards central (head-on) collisions. The J/ψ nuclear modification factor RAA exhibits a strong pT dependence with a large suppression at high pT and an increase to unity for decreasing pT. When integrating over the measured momentum range pT<10 GeV/c, the J/ψ RAA shows a weak centrality dependence. Each measurement is compared with results at lower center-of-mass energies and with ALICE measurements at forward rapidity, as well as to theory calculations. All reported features of the J/ψ production at low pT are consistent with a dominant contribution to the J/ψ yield originating from charm quark (re)combination.
This paper presents the first measurements of the charge independent (CI) and charge dependent (CD) two-particle transverse momentum correlators GCI 2 and GCD 2 in Pb–Pb collisions at √sNN = 2.76 TeV by the ALICE collaboration. The two-particle transverse momentum correlator G2 was introduced as a measure of the momentum current transfer between neighboring system cells. The correlators are measured as a function of pair separation in pseudorapidity (Δη) and azimuth (Δφ) and as a function of collision centrality. From peripheral to central collisions, the correlator GCI 2 exhibits a longitudinal broadening while undergoing a monotonic azimuthal narrowing. By contrast, GCD 2 exhibits a narrowing along both dimensions. These features are not reproduced by models such as HIJING and AMPT. However, the observed narrowing of the correlators from peripheral to central collisions is expected to result from the stronger transverse flow profiles produced in more central collisions and the longitudinal broadening is predicted to be sensitive to momentum currents and the shear viscosity per unit of entropy density η/s of the matter produced in the collisions. The observed broadening is found to be consistent with the hypothesized lower bound of η/s and is in qualitative agreement with values obtained from anisotropic flow measurements.
This Letter presents the first direct investigation of the p–0 interaction, using the femtoscopy technique in high-multiplicity pp collisions at √s = 13 TeV measured by the ALICE detector. The 0 is reconstructed via the decay channel to Λγ, and the subsequent decay of Λ to pπ−. The photon is detected via the conversion in material to e+e− pairs exploiting the capability of the ALICE detector to measure electrons at low transverse momenta. The measured p–0 correlation indicates a shallow strong interaction. The comparison of the data to several theoretical predictions obtained employing the Correlation Analysis Tool using the Schrödinger Equation (CATS) and the Lednický–Lyuboshits approach shows that the current experimental precision does not yet allow to discriminate between different models, as it is the case for the available scattering and hypernuclei data. Nevertheless, the p–0 correlation function is found to be sensitive to the strong interaction, and driven by the interplay of the different spin and isospin channels. This pioneering study demonstrates the feasibility of a femtoscopic measurement in the p–0 channel and with the expected larger data samples in LHC Run 3 and Run 4, the p–0 interaction will be constrained with high precision.
ϒ production in p–Pb interactions is studied at the centre-of-mass energy per nucleon–nucleon collision √sNN = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03 < ycms < 3.53 and −4.46 < ycms < −2.96, down to zero transverse momentum. In this work, results on the ϒ(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the ϒ(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the ϒ(2S) nuclear modification factor is evaluated, suggesting a suppression similar to that of the ϒ(1S). A first measurement of the ϒ(3S) has also been performed. Finally, results are compared with previous ALICE measurements in p–Pb collisions at √sNN = 5.02 TeV and with theoretical calculations.
Measurements of K∗(892)0 and φ(1020) resonance production in Pb–Pb and pp collisions at √sNN = 5.02 TeV with the ALICE detector at the Large Hadron Collider are reported. The resonances are measured at midrapidity (|y| < 0.5) via their hadronic decay channels and the transverse momentum (pT) distributions are obtained for various collision centrality classes up to pT = 20 GeV/c. The pT-integrated yield ratio K∗(892)0/K in Pb–Pb collisions shows significant suppression relative to pp collisions and decreases towards more central collisions. In contrast, the φ(1020)/K ratio does not show any suppression. Furthermore, the measured K∗(892)0/K ratio in central Pb–Pb collisions is significantly suppressed with respect to the expectations based on a thermal model calculation, while the φ(1020)/K ratio agrees with the model prediction. These measurements are an experimental demonstration of rescattering of K∗(892)0 decay products in the hadronic phase of the collisions. The K∗(892)0/K yield ratios in Pb–Pb and pp collisions are used to estimate the time duration between chemical and kinetic freeze-out, which is found to be ∼ 4–7 fm/c for central collisions. The pT-differential ratios of K∗(892)0/K, φ(1020)/K, K∗(892)0/π , φ(1020)/π , p/K∗(892)0 and p/φ(1020) are also presented for Pb–Pb and pp collisions at √sNN = 5.02 TeV. These ratios show that the rescattering effect is predominantly a low-pT phenomenon.
The first evidence of spin alignment of vector mesons (K*0 and ϕ) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The spin density matrix element ρ00 is measured at midrapidity (|y|< 0.5) in Pb-Pb collisions at a center-of-mass energy (√sNN) of 2.76 TeV
with the ALICE detector. ρ00 values are found to be less than 1/3 (1/3 implies no spin alignment) at low transverse momentum (pT<2 GeV/c) for K*0 and ϕ at a level of 3σ and 2σ, respectively. No significant spin alignment is observed for the K0S meson (spin = 0) in Pb-Pb collisions and for the vector mesons in pp collisions. The measured spin alignment is unexpectedly large but qualitatively consistent with the expectation from models which attribute it to a polarization of quarks in the presence of angular momentum in heavy-ion collisions and a subsequent hadronization by the process of recombination.
The transverse momentum (pT) differential yields of (anti-)3He and (anti-)3H measured in p-Pb collisions at sNN−−−√ = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the pT-integrated yields of (anti-)3He and (anti-)3H to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)3He and (anti-)3H. For (anti-)3He, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of 4He¯ is determined.
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in the presence of ligands typically needed to populate defined conformational states. To overcome this key limitation, we developed an in vitro selection platform based on synthetic single domain antibodies named sybodies. To target the limited hydrophilic surfaces of membrane proteins, we designed three sybody libraries that exhibit different shapes and moderate hydrophobicity of the randomized surface. A robust binder selection cascade combining ribosome and phage display enabled the generation of conformation-selective, high affinity sybodies against an ABC transporter and two previously intractable human SLC transporters, GlyT1 and ENT1. The platform does not require access to animal facilities and builds exclusively on commercially available reagents, thus enabling every lab to rapidly generate binders against challenging membrane proteins.
Nicht nur in Kinofilmen wie "Der Untergang", sondern auch in Fernsehfilmen und Dokumentationen sind Hitler und seine Paladine längst zu Stars geworden, die für hohe Einschaltquoten sorgen. Peter Zimmermann stellt die aktuelle "Hitleritis" in die Tradition medialer "Vergangenheitsbewältigung" in der Geschichte von BRD und DDR. Die Täter des NS-Regimes, die seit Mitte der 90er Jahre in das Zentrum der Fernseharstellungen rücken, sind nicht diejenigen, die nach 1945 in Deutschland wieder Karriere gemacht haben, sie bleiben auf die Person "Hitler" (ZDF 1995) bzw. "Hitlers Helfer" (ZDF 1996) beschränkt. Neuerdings wird dabei auch die menschliche Seite der Täter gezeigt. Mit der Personalisierung historischer Prozesse werden, so Zimmermann, Personenkult und Ikonographie des Dritten Reichs nicht aufgebrochen sondern vielmehr - kritisch gewendet - wieder neu reproduziert.
Die dokumentarische Aufarbeitung des 'Dritten Reichs' stößt auf ein grundsätzliches Dilemma: Sie ist auf Bilddokumente aus der NS-Zeit angewiesen, deren starke Suggestivkraft häufig im Widerspruch zur Aufklärungsabsicht eines Filmbeitrags steht. Bis in die 1980er Jahre stand die filmische Vergangenheitsbewältigung unter dem Einfluss des 'Kalten Krieges': Was im einen Teil Deutschlands im Vordergrund der Darstellung stand, wurde im anderen verdrängt. So konzentrierte man sich in der BRD auf Hitlers NSDAP und die Judenverfolgung, in der DDR auf die Verflechtung des Regimes mit kapitalistischen Wirtschaftsinteressen und die Kontinuität von Nazi-Karrieren in der Bundesrepublik. Peter Zimmermann analysiert in diesem Beitrag ausgewählte Filmdokumente von der Nachkriegszeit bis in die Gegenwart und fordert die Dekonstruktion der erstarrten filmischen Ikonographie des 'Dritten Reichs'.
"Alle Dinge haben ihren Nutzen und ihren Teil und ihren rechten Platz im Haushalt der Natur." Mark Twain Damit dieses so bleibt, hat das Land Baden-Württemberg Artenhilfsprogramme für solche Tier- und Pflanzenarten in Leben gerufen, der Existenz durch unterschiedliche Aktivitäten des Menschen akut bedroht ist. Künftigen Generationen ein vielfältiges Artenspektrum zu erhalten, ist eine vorrangige Aufgabe unserer Gesellschaft. Mögliche Wege aufzuzeigen und von der Notwendigkeit geeigneter Hilfsmaßnahmen zu überzeugen, ist Ziel dieses Blattes.
Propagandafilme der NSDAP
(2005)
Dass dokumentarische Filme auch Propagandazwecken dienen können, war in den 20er und 30er Jahren international akzeptierter Konsens. Der nationalsozialistische Propagandafilm war, so gesehen, keine ausgesprochene dokumentarische Entgleisung. Wie die nationalsozialistische Partei und später der NS-Staat den Dokumentarfilm nutzten, um ihre Ideologie und Ziele zu verbreiten, untersucht Peter Zimmermann in diesem Beitrag. Er behandelt den nationalsozialistischen Propagandafilm von den Anfängen der Wahlwerbung über die Parteitagsfilme bis zur Verbreitung der arischen Rassenideologie. Besonderes Augenmerk legt er auf die Ästhetik der Riefenstahl-Filme mit ihrer idealisierenden Verklärung Hitlers und der NSDAP und auf die filmische Konstruktion von Feindbildern wie in Hipplers Propagandafilm "Der ewige Jude". Die einzelnen Kapitel sind Auszüge aus Band 3 des Sammelwerks "Geschichte des dokumentarischen Films in Deutschland".
Aus Anlass des Fernseh-Sendebeginns in West- und Ostdeutschland vor 50 Jahren fand im Hans-Bredow-Institut in Hamburg am 5. und 6. Dezember 2002 ein Symposion unter dem Titel "Fernsehgeschichte als Zeitgeschichte - Zeitgeschichte als Fernsehgeschichte" statt. In einem kritischen Beitrag untersuchte Peter Zimmermann vor allem die "Feindbildkonstruktionen" des westlichen Fernsehens, die sich nach Aufffassung des Referenten auch bis nach dem Fall der Mauer nachweisen lassen. Zimmermann: "Im freudetrunkenen Monat November des Jahres 1989 schien das deutsche Wintermärchen mit dem Fall der Mauer endlich ein glückliches Ende zu finden. Ganz ungetrübt verlief die Wiedervereinigung der 'deutschen Brüder und Schwestern' allerdings auch in medialer Hinsicht nicht. Mit der sogenannten Abwicklung des DDR-Fernsehens und der DEFA übernahm das Fernsehen der Bundesrepublik auch die ostdeutsche 'Bilderhoheit'. Die in Film und Fernsehen der DDR bislang dominanten positiven Selbstbilder wurden fortan durch die im Westen dominierenden negativen Fremdbilder ersetzt. Es ist daher wenig verwunderlich, dass seit der Wiedervereinigung in den Fernsehdokumentationen zur deutschen Geschichte fast ausnahmslos der westdeutsche Blick dominiert und die Geschichte der DDR marginalisiert, abgewertet oder karikiert wird."
Der Aufsatz "Zwischen Sachlichkeit, Idylle und Propaganda. Der Kulturfilm im Dritten Reich" von Peter Zimmermann beschäftigt sich mit der Nazi-Propaganda in den Filmen des Dritten Reiches. Dabei analysiert er typische Kulturfilme dieser Zeit und stellt die These auf, dass der Kulturfilm des Dritten Reichs vielfältiger, widersprüchlicher und in weiten Teilen weniger propagandistisch gewesen zu sein scheint, als es das kritische Stereotyp wahrhaben möchte.
The aim of our study was to reveal the differences in the species composition and soil properties of open sandy grasslands dominated by different Festuca species, Festuca vaginata and F. pseudovaginata. Due to the arid conditions, sandy grasslands are generally covered by xerothermic vegetation in which F. vaginata is a typical dominant species. Festuca pseudovaginata, a species newly described by the authors, can also gain dominance in sandy grasslands. However, species composition and soil properties of grasslands dominated by this recently discovered species are still undiscovered. Based on previous coenological studies, we hypothesised that the grasslands characterised by the endemic F. vaginata are more species-rich than those with F.pseudovaginata.
Coenological sampling was carried out in May 2009 at two study sites using the Braun-Blanquet method in quadrats of 2 m × 2 m. Five relevés were sampled in stands dominated by F. vaginata and F. pseudovaginata respectively at two study sites in Central Hungary, resulting in a total of twenty relevés. Analyses were based on the cover scores of vascular plant species and cryptogam crust and values of seven soil properties (pH [KCl], pH [H2O], humus, total N, Ca, P2O5 and K2O) measured in the 0–15 and 15–30 cm soil layers. Soil properties of the grasslands dominated by F. pseudovaginata and F. vaginata (dependent variables) were compared by linear mixed models, where ‘grassland type’ was the fixed factor and ‘site nested in grassland type’ was considered as random factor. Data were analysed by cluster analysis, fusion algorithm was a combinatorial method (minimising increase of variance), and the correlation was used as comparative function. We compared the cover of subordinate species by Mann-Whitney U test. We found that F. pseudovaginata and F. vaginata samples were well separated, and grasslands dominated by F. pseudovaginata had nearly two times more species than those dominated by F. vaginata. Based on the cluster analyses using plant cover and upper 0–15 cm soil layer data, F. pseudovaginata and F. vaginata groups could be well separated. Linear mixed models revealed that F. vaginata grasslands were typical on soils with higher pH, nitrogen, phosphorous and potassium contents compared to F. pseudovaginata grasslands, which indicates a tight connection between the properties of the upper soil layer and the vegetation in sandy grasslands.
Kaum eine andere Industrie wurde in den vergangenen beiden Jahrzehnten so massiv durch den Einzug der Informationstechnologie geprägt wie der Wertpapierhandel. Traditionelle Geschäftsmodelle haben sich grundlegend verändert. Das klassische Börsenparkett ist nahezu vollständig elektronischen Handelsplattformen gewichen.
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells. BK channels have been shown to be composed of the pore-forming alpha-subunit coexpressed with the auxiliary beta-1-subunit. Analyzing the hearing function and cochlear phenotype of BK channel alpha-(BKalpha–/–) and beta-1-subunit (BKbeta-1–/–) knockout mice, we demonstrate normal hearing function and cochlear structure of BKbeta-1–/– mice. During the first 4 postnatal weeks also, BKalpha–/– mice most surprisingly did not show any obvious hearing deficits. High-frequency hearing loss developed in BKalpha–/– mice only from ca. 8 weeks postnatally onward and was accompanied by a lack of distortion product otoacoustic emissions, suggesting outer hair cell (OHC) dysfunction. Hearing loss was linked to a loss of the KCNQ4 potassium channel in membranes of OHCs in the basal and midbasal cochlear turn, preceding hair cell degeneration and leading to a similar phenotype as elicited by pharmacologic blockade of KCNQ4 channels. Although the actual link between BK gene deletion, loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations. © 2004, The National Academy of Sciences. Freely available online through the PNAS open access option.
The UN 2030 Agenda for Sustainable Development stresses the fundamental role science should play in implementing the 17 Sustainable Development Goals endorsed by the global community. But how can and should researchers respond to this societal demand on science? We argue that answering this question requires systematic engagement with the fundamental normative dimensions of the 2030 Agenda and those of the scientific community—and with the implications these dimensions have for research and practice. We suggest that the production of knowledge relevant to sustainable development entails analytic engagement with norms and values through four tasks. First, to unravel and critically reflect on the ethical values involved in sustainability, values should increasingly become an empirical and theoretical object of sustainability research. Second, to ensure that research on social–ecological systems is related to sustainability values, researchers should reflect on and spell out what sustainability values guide their research, taking into account possible interdependencies, synergies, and trade-offs. Third, to find common ground on what sustainability means for specific situations, scientists should engage in deliberative learning processes with societal actors, with a view to jointly reflecting on existing development visions and creating new, contextualized ones. Fourth, this implies that researchers and scientific disciplines must clarify their own ethical and epistemic values, as this defines accountability and shapes identification of problems, research questions, and results. We believe that ignoring these tasks, whether one is in favor or critical of the 2030 Agenda, will undermine the credibility and relevance of scientific contributions for sustainable development.
Am 27. und 28. September 2005 tagten Historiker und Philosophen der Mathematik und Naturwissenschaften in Frankfurt a.M. im Gebäude des Physikalischen Vereins. Eine Besonderheit des Internationalen Symposiums war der Dialog mit Vertretern der aktuellen Grundlagendebatte der Basiswissenschaft Physik. In zwölf Vorträgen wurden an zwei Tagen Raum- und Zeitkonzeptionen bedeutender Naturphilosophen der letzten 400 Jahre vorgestellt. Naturwissenschaftshistoriker rekonstruierten die Entwürfe von Giordano Bruno, Marin Mersenne, René Descartes, Otto von Guericke, Baruch Spinoza, Gottfried Wilhelm Leibniz, Isaac Newton und Leonhard Euler, während Grundlagentheoretiker der Physik einen Überblick über eigene Konzeptionen mit einem systematischen Anschluss an die Denktraditionen vorführten. Die Tagung wurde von der Fritz Thyssen Stiftung gefördert sowie vom Förderverein des Frankfurter Institutes für Geschichte der Naturwissenschaften "Arbor Scientiarum" und dem Physikalischen Verein finanziell unterstützt. ...
Background: Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failure associated with severe graft versus host disease (GvHD) necessitating pharmaceutical intervention post-transplant. Whether immunosuppression with mycophenolate mofetil (MMF) or Ciclosporin A (CsA) influences the cytotoxic effect of CIK cell immunotherapy is still an open issue.
Methods: CIK cells were generated from PBMC as previously described followed by co-incubation with mycophenolic acid (MPA) or CsA. Proliferation, cytotoxicity and receptor expression were investigated following short- (24 h), intermediate- (3 days) and long-term (7 days) MPA incubation with the intention to simulate the in vivo situation when CIK cells were given to a patient with relevant MPA/CsA plasma levels.
Results: Short-term MPA treatment led to unchanged proliferation capacity and barely had any effect on viability and cytotoxic capability in vitro. The composition of CIK cells with respect to T-, NK-like T- and NK cells remained stable. Intermediate MPA treatment lacked effects on NKG2D, FasL and TRAIL receptor expression, while an influence on proliferation and viability was detectable. Furthermore, long-term treatment significantly impaired proliferation, restricted viability and drastically reduced migration-relevant receptors accompanied by an alteration in the CD4/CD8 ratio. CD3+CD56+ cells upregulated receptors relevant for CIK cell killing and migration, whereas T cells showed the most interference through significant reductions in receptor expression. Interestingly, CsA treatment had no significant influence on CIK cell viability and the cytotoxic potential against K562.
Conclusions: Our data indicate that if immunosuppressant therapy is indispensable, efficacy of CIK cells is maintained at least short-term, although more frequent dosing might be necessary.
Geometrical frustration among interacting spins combined with strong quantum fluctuations destabilize long-range magnetic order in favor of more exotic states such as spin liquids. By following this guiding principle, a number of spin liquid candidate systems were identified in quasi-two-dimensional (quasi-2D) systems. For 3D, however, the situation is less favorable as quantum fluctuations are reduced and competing states become more relevant. Here we report a comprehensive study of thermodynamic, magnetic and dielectric properties on single crystalline and pressed-powder samples of PbCuTe2O6, a candidate material for a 3D frustrated quantum spin liquid featuring a hyperkagome lattice. Whereas the low-temperature properties of the powder samples are consistent with the recently proposed quantum spin liquid state, an even more exotic behavior is revealed for the single crystals. These crystals show ferroelectric order at TFE ≈ 1 K, accompanied by strong lattice distortions, and a modified magnetic response—still consistent with a quantum spin liquid—but with clear indications for quantum critical behavior.
Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to the tissue’s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient metabolic resources to support growth and proliferation. How endothelial nutrient acquisition and usage are regulated is unknown. Here we show that these processes are instructed by Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator 1 (WWTR1/TAZ)-transcriptional enhanced associate domain (TEAD): a transcriptional module whose function is highly responsive to changes in the tissue environment. ECs lacking YAP/TAZ or their transcriptional partners, TEAD1, 2 and 4 fail to divide, resulting in stunted vascular growth in mice. Conversely, activation of TAZ, the more abundant paralogue in ECs, boosts proliferation, leading to vascular hyperplasia. We find that YAP/TAZ promote angiogenesis by fuelling nutrient-dependent mTORC1 signalling. By orchestrating the transcription of a repertoire of cell-surface transporters, including the large neutral amino acid transporter SLC7A5, YAP/TAZ-TEAD stimulate the import of amino acids and other essential nutrients, thereby enabling mTORC1 activation. Dissociating mTORC1 from these nutrient inputs—elicited by the loss of Rag GTPases—inhibits mTORC1 activity and prevents YAP/TAZ-dependent vascular growth. Together, these findings define a pivotal role for YAP/TAZ-TEAD in controlling endothelial mTORC1 and illustrate the essentiality of coordinated nutrient fluxes in the vasculature.
Securities transaction tax in France: impact on market quality and inter-market price coordination
(2014)
The general concept of a Securities Transaction Tax is controversial among academics and politicians. While theoretical research is quite advanced, the empirical guidance in a fragmented market context is still scarce. Possible negative effects for market liquidity and market efficiency are theoretically predicted, but have not been empirically tested yet. In light of the agreement of eleven European member states to implement an STT, this study aims to give a comprehensive overview of the effects of the STT, introduced in France in 2012, on liquidity demand, liquidity supply, volatility and inter-market information transmission. The results show that the STT has led to a decline in liquidity demand, has had a detrimental effect on liquidity supply and negatively influences the inter-market information transmission efficiency. However, no effect on volatility can be observed.
The ALICE experimentatthe LHC (CERN)iscurrently developinganew software framework designed for Run3: detector and software will havetocope with Pb–Pb collision rates 100 times higher than today, leadingtothe combinationofcore Online-Offline operations intoasingle framework called O2. The analysis code is expectedtorunonafew large Analysis Facilities counting 20k cores and sustaining a 100 GB/s throughput: this requiresaconjoint effort between the definitionofthe data format, the configurationofthe Analysis Facilities and the developmentofthe Analysis Framework. Wepresent the prototypeofanew Analysis Object Data format basedontimeframes and optimized for continuous readout. Such formatisdesigned tobeextensible and transported efficiently over the network. Wealso present the first iterationofthe Analysis Framework, basedonthe O2 Data Processing Layer and leveraging message passing acrossatopologyofprocesses. Wewill also illustrate the implementation and benchmarkingofacompatibility layer designedtomitigate the transition from the current event-oriented analysis modeltothe new time-oriented one. Finally,wewill giveastatus reportonthe integrationofthe Analysis Framework and Analysis Facilities for Run3into the current organized analysis model in ALICE.
Next-generation sequencing (NGS) provides unrestricted access to the genome, but it produces ‘big data’ exceeding in amount and complexity the classical analytical approaches. We introduce a bioinformatics-based classifying biomarker that uses emergent properties in genetics to separate pain patients requiring extremely high opioid doses from controls. Following precisely calculated selection of the 34 most informative markers in the OPRM1, OPRK1, OPRD1 and SIGMAR1 genes, pattern of genotypes belonging to either patient group could be derived using a k-nearest neighbor (kNN) classifier that provided a diagnostic accuracy of 80.6±4%. This outperformed alternative classifiers such as reportedly functional opioid receptor gene variants or complex biomarkers obtained via multiple regression or decision tree analysis. The accumulation of several genetic variants with only minor functional influences may result in a qualitative consequence affecting complex phenotypes, pointing at emergent properties in genetics.
Background: Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study.
Patients and methods: 102 unresectable or metastatic BTC patients with histologically proven adenocarcinoma of gallbladder or intrahepatic bile ducts, Eastern Cooperative Oncology Group (ECOG) 0–2 were randomised to gemcitabine (1000 mg/m2 once weekly, first 7-weeks + 1-week rest followed by once 3-weeks + 1-week rest) plus sorafenib (400 mg twice daily) or placebo. Treatment continued until progression or unacceptable toxicity. Tumour samples were prospectively stained for sorafenib targets and potential biomarkers. Serum samples (first two cycles) were measured for vascular endothelial growth factors (VEGFs), vascular endothelial growth factor receptor 2 (VEGFR-2) and stromal cell-derived factor 1 (SDF1)α by enzyme-linked immunosorbent assay (ELISA).
Results: Gemcitabine plus sorafenib was generally well tolerated. Four and three patients achieved partial responses in the sorafenib and placebo groups, respectively. There was no difference in the primary end-point, median progression-free survival (PFS) for gemcitabine plus sorafenib versus gemcitabine plus placebo (3.0 versus 4.9 months, P = 0.859), and no difference for median overall survival (OS) (8.4 versus 11.2 months, P = 0.775). Patients with liver metastasis after resection of primary BTC survived longer with sorafenib (P = 0.019) compared to placebo. Patients who developed hand-foot syndrome (HFS) showed longer PFS and OS than patients without HFS. Two sorafenib targets, VEGFR-2 and c-kit, were not expressed in BTC samples. VEGFR-3 and Hif1α were associated with lymph node metastases and T stage. Absence of PDGFRβ expression correlated with longer PFS.
Conclusion: The addition of sorafenib to gemcitabine did not demonstrate improved efficacy in advanced BTC patients. Biomarker subgroup analysis suggested that some patients might benefit from combined treatment.