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The solution structure of the lantibiotic immunity protein NisI and its interactions with nisin
(2015)
Hacker, Carolin ; Christ, Nina A. ; Duchardt-Ferner, Elke ; Korn, Sophie ; Göbl, Christoph ; Berninger, Lucija ; Düsterhus, Stefanie ; Hellmich, Ute ; Madl, Tobias ; Kötter, Peter ; Entian, Karl-Dieter ; Wöhnert, Jens
Many Gram-positive bacteria produce lantibiotics, genetically encoded and posttranslationally modified peptide antibiotics, which inhibit the growth of other Gram-positive bacteria. To protect themselves against their own lantibiotics these bacteria express a variety of immunity proteins including the LanI lipoproteins. The structural and mechanistic basis for LanI-mediated lantibiotic immunity is not yet understood. Lactococcus lactis produces the lantibiotic nisin, which is widely used as a food preservative. Its LanI protein NisI provides immunity against nisin but not against structurally very similar lantibiotics from other species such as subtilin from Bacillus subtilis. To understand the structural basis for LanI-mediated immunity and their specificity we investigated the structure of NisI. We found that NisI is a two-domain protein. Surprisingly, each of the two NisI domains has the same structure as the LanI protein from B. subtilis, SpaI, despite the lack of significant sequence homology. The two NisI domains and SpaI differ strongly in their surface properties and function. Additionally, SpaI-mediated lantibiotic immunity depends on the presence of a basic unstructured N-terminal region that tethers SpaI to the membrane. Such a region is absent from NisI. Instead, the N-terminal domain of NisI interacts with membranes but not with nisin. In contrast, the C-terminal domain specifically binds nisin and modulates the membrane affinity of the N-terminal domain. Thus, our results reveal an unexpected structural relationship between NisI and SpaI and shed light on the structural basis for LanI mediated lantibiotic immunity.
Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages
(2015)
Snodgrass, Ryan G. ; Boß, Marcel ; Zezina, Ekaterina ; Weigert, Andreas ; Dehne, Nathalie ; Fleming, Ingrid ; Brüne, Bernhard ; Namgaladze, Dmitry
Pro-inflammatory cytokines secreted by adipose tissue macrophages (ATMs) contribute to chronic low-grade inflammation and obesity-induced insulin resistance. Recent studies have shown that adipose tissue hypoxia promotes an inflammatory phenotype in ATMs. However, our understanding of how hypoxia modulates the response of ATMs to free fatty acids within obese adipose tissue is limited. We examined the effects of hypoxia (1% O2) on the pro-inflammatory responses of human monocyte-derived macrophages to the saturated fatty acid palmitate. Compared with normoxia, hypoxia significantly increased palmitate-induced mRNA expression and protein secretion of IL-6 and IL-1β. Although palmitate-induced endoplasmic reticulum stress and nuclear factor κB pathway activation were not enhanced by hypoxia, hypoxia increased the activation of JNK and p38 mitogen-activated protein kinase signaling in palmitate-treated cells. Inhibition of JNK blocked the hypoxic induction of pro-inflammatory cytokine expression, whereas knockdown of hypoxia-induced transcription factors HIF-1α and HIF-2α alone or in combination failed to reduce IL-6 and only modestly reduced IL-1β gene expression in palmitate-treated hypoxic macrophages. Enhanced pro-inflammatory cytokine production and JNK activity under hypoxia were prevented by inhibiting reactive oxygen species generation. In addition, silencing of dual-specificity phosphatase 16 increased normoxic levels of IL-6 and IL-1β and reduced the hypoxic potentiation in palmitate-treated macrophages. The secretome of hypoxic palmitate-treated macrophages promoted IL-6 and macrophage chemoattractant protein 1 expression in primary human adipocytes, which was sensitive to macrophage JNK inhibition. Our results reveal that the coexistence of hypoxia along with free fatty acids exacerbates macrophage-mediated inflammation.
Viele Städte in Deutschland stehen aktuell vor komplexen ökonomischen, ökologischen und sozialen Herausforderungen, die mit klassischen ressortbezogenen Planungskonzepten nicht zu bewältigen sind. Integrierte Stadtentwicklungskonzepte erleben deshalb vielerorts eine Renaissance in der städtischen Planungspraxis. Die in diesem Zusammenhang diskutierten Planungsleitbilder geben jedoch nur selten direkt umsetzbare Handlungskonzepte vor. In diesem Beitrag werden deshalb am Beispiel der Stadt Leipzig konkrete Handlungsoptionen für eine an nachhaltiger Mobilität orientierte Stadtentwicklung vorgestellt. Aufbauend auf bisherigen Erkenntnissen zu integrierten Stadtentwicklungskonzepten werden zunächst infrastrukturbezogene Konzepte zur Förderung des Wohnens im Innenbereich, zur Stärkung städtischer Zentren sowie zur Förderung der Nahmobilität dargestellt. Darüber hinaus werden auch politische, organisatorische und kommunikative Handlungsoptionen aufgezeigt. Diese umfassen Maßnahmen zur Verbesserung der übergeordneten Rahmenbedingungen, Konzepte zur Stärkung der inter- und intrakommunalen Kooperation sowie integrierte städtische Mobilitätskonzepte. Das Beispiel Leipzig macht dabei deutlich, dass infrastrukturelle Ansätze für eine an nachhaltiger Mobilitätsgestaltung orientierte Stadtentwicklung nicht ausreichend sind. Vielmehr ist eine bessere Abstimmung der Stadt- und Verkehrsplanung auf die Bedürfnisse der Bevölkerung erforderlich; dazu gehört auch die Integration von Mobilitätsmanagementmaßnahmen in städtische Verkehrskonzepte. Für eine wirksame Umsetzung integrierter Stadtentwicklungskonzepte erscheinen außerdem eine an Nachhaltigkeitszielen orientierte Gestaltung der rechtlichen und politischen Rahmenbedingungen sowie eine stärkere Berücksichtigung regionaler Verknüpfungen in städtischen Planungen notwendig.
Winkel, Angelika F. ; Engel, Christian K. ; Margerie, Daniel ; Kannt, Aimo ; Szillat, Hauke ; Glombik, Heiner ; Kallus, Christopher ; Ruf, Sven ; Güssregen, Stefan ; Riedel, Jens ; Herling, Andreas W. ; Knethen, Andreas von ; Weigert, Andreas ; Brüne, Bernhard ; Schmoll, Dieter
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors, the activity of Nrf2 is inhibited by its interaction with the Keap1 (kelch-like ECH-associated protein 1). Here, we describe (3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid (RA839), a small molecule that binds noncovalently to the Nrf2-interacting kelch domain of Keap1 with a Kd of ∼6 μm, as demonstrated by x-ray co-crystallization and isothermal titration calorimetry. Whole genome DNA arrays showed that at 10 μm RA839 significantly regulated 105 probe sets in bone marrow-derived macrophages. Canonical pathway mapping of these probe sets revealed an activation of pathways linked with Nrf2 signaling. These pathways were also activated after the activation of Nrf2 by the silencing of Keap1 expression. RA839 regulated only two genes in Nrf2 knock-out macrophages. Similar to the activation of Nrf2 by either silencing of Keap1 expression or by the reactive compound 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester (CDDO-Me), RA839 prevented the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. In mice, RA839 acutely induced Nrf2 target gene expression in liver. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.
Namgaladze, Dmitry ; Snodgrass, Ryan G. ; Angioni, Carlo ; Großmann, Nina ; Dehne, Nathalie ; Geisslinger, Gerd ; Brüne, Bernhard
Macrophages respond to the Th2 cytokine IL-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15). Although IL-4 signaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory processes in a context-dependent manner. AMP-activated protein kinase (AMPK) is a metabolic sensor/regulator that supports an anti-inflammatory macrophage phenotype. How AMPK activation is linked to IL-4-elicited gene signatures remains unexplored. Using primary human macrophages stimulated with IL-4, we observed elevated ALOX15 mRNA and protein expression, which was attenuated by AMPK activation. AMPK activators, e.g. phenformin and aminoimidazole-4-carboxamide 1-β-d-ribofuranoside inhibited IL-4-evoked activation of STAT3 while leaving activation of STAT6 and induction of typical IL-4-responsive genes intact. In addition, phenformin prevented IL-4-induced association of STAT6 and Lys-9 acetylation of histone H3 at the ALOX15 promoter. Activating AMPK abolished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-stimulated macrophages, which was mimicked by ALOX15 knockdown. Finally, pretreatment of macrophages with IL-4 for 48 h increased the mRNA expression of the proinflammatory cytokines IL-6, IL-12, CXCL9, and CXCL10 induced by subsequent stimulation with lipopolysaccharide. This response was attenuated by inhibition of ALOX15 or activation of AMPK during incubation with IL-4. In conclusion, limiting ALOX15 expression by AMPK may promote an anti-inflammatory phenotype of IL-4-stimulated human macrophages.
The aim of the present overview article is to raise awareness of an essential aspect that is usually not accounted for in the modelling of electron transport for focused-electron-beam-induced deposition (FEBID) of nanostructures: Surface excitations are on the one hand responsible for a sizeable fraction of the intensity in reflection-electron-energy-loss spectra for primary electron energies of up to a few kiloelectronvolts and, on the other hand, they play a key role in the emission of secondary electrons from solids, regardless of the primary energy. In this overview work we present a general perspective of recent works on the subject of surface excitations and on low-energy electron transport, highlighting the most relevant aspects for the modelling of electron transport in FEBID simulations.
Oxygen vacancies in strontium titanate surfaces (SrTiO3) have been linked to the presence of a two-dimensional electron gas with unique behavior. We perform a detailed density functional theory study of the lattice and electronic structure of SrTiO3 slabs with multiple oxygen vacancies, with a main focus on two vacancies near a titanium dioxide terminated SrTiO3 surface. We conclude based on total energies that the two vacancies preferably inhabit the first two layers, i.e. they cluster vertically, while in the direction parallel to the surface, the vacancies show a weak tendency towards equal spacing. Analysis of the nonmagnetic electronic structure indicates that oxygen defects in the surface TiO2 layer lead to population of Ti ${{t}_{2g}}$ states and thus itinerancy of the electrons donated by the oxygen vacancy. In contrast, electrons from subsurface oxygen vacancies populate Ti eg states and remain localized on the two Ti ions neighboring the vacancy. We find that both the formation of a bound oxygen-vacancy state composed of hybridized Ti 3eg and 4p states neighboring the oxygen vacancy as well as the elastic deformation after extracting oxygen contribute to the stabilization of the in-gap state.
Untreated periodontal disease may influence general health. However, how may a physician, who is not trained in periodontal probing, detect untreated periodontitis?
Activated matrix metalloproteinase-8 (aMMP-
8) in saliva correlates with periodontal probing parameters. Thus, sensitivity and specificity of a chair-side test for aMMP-8 to detect periodontitis were evaluated. Thirty cases [untreated chronic periodontitis (ChP); 15 generalized moderate and 15 generalized severe] and 30 controls [probing depths (PD) ≤3 mm, vertical probing attachment level (PAL-V) ≤2 mm at <30 % of sites) were examined periodontally (PD, PAL-V, bleeding on probing). Subsequently, the aMMP-8 test was performed. The test kit
becomes positive with ≥25 ng/ml aMMP-8 in the sample.
The aMMP-8 test was positive in 87 % of ChP and in 40 % of controls. That corresponds to a sensitivity of 87 % and a specificity of 60 %. The sensitivity to detect generalized severe ChP was 93 % (60 % specificity). Backward
stepwise logistic regression analysis to explain positive
aMMP-8 tests identified exclusively ChP with an odds of 9.8 (p < 0.001). Positive results of the aMMP-8 test significantly correlate with generalized ChP. The aMMP-8 test may be used by physicians to detect periodontitis in their patients.
Abelev, Betty ; Adam, Jaroslav ; Adamová, Dagmar ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agostinelli, Andrea ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmed, Ijaz ; Ahn, Sang Un ; Ahn, Sul-Ah ; Aimo, Ilaria ; Aiola, Salvatore ; Ajaz, Muhammad ; Akindinov, Alexander ; Alam, Sk Noor ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alexandre, Didier ; Alici, Andrea ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altinpinar, Sedat ; Altsybeev, Igor ; Prado, Caio Alves Garcia ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anielski, Jonas ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Armesto Perez, Nestor ; Arnaldi, Roberta ; Aronsson, Tomas ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, Terry ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Renu ; Baldisseri, Alberto ; Baltasar Dos Santos Pedrosa, Fernando ; Baral, Rama Chandra ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Ramillien Barret, Valerie ; Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Basu, Sumit ; Bathen, Bastian ; Batigne, Guillaume ; Batista Camejo, Arianna ; Batyunya, Boris ; Bätzing, Paul Christoph ; Baumann, Christoph Heinrich ; Bearden, Ian Gardner ; Beck, Hans ; Bedda, Cristina ; Behera, Nirbhay Kumar ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont Moreno, Ernesto ; Belmont Iii, Ronald John ; Belyaev, Vladimir ; Bencédi, Gyula ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berényi, Dániel ; Berger, Martin Emanuel ; Bertens, Redmer Alexander ; Berzano, Dario ; Betev, Latchezar ; Bhasin, Anju ; Bhat, Inayat Rasool ; Bhati, Ashok Kumar ; Bhattacharjee, Buddhadeb ; Bhom, Jihyun ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Bjelogrlic, Sandro ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Bock, Friederike ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubskiy, Mikhail ; Boehmer, Felix Valentin ; Boldizsar, Laszlo ; Bombara, Marek ; Book, Julian ; Borel, Herve ; Borissov, Alexander ; Bossú, Francesco ; Botje, Michiel ; Botta, Elena ; Boettger, Stefan ; Braun-Munzinger, Peter ; Bregant, Marco ; Breitner, Timo ; Broker, Theo Alexander ; Browning, Tyler Allen ; Broz, Michal ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bunčić, Predrag ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caffarri, Davide ; Cai, Xu ; Caines, Helen Louise ; Calero Diaz, Liliet ; Caliva, Alberto ; Calvo Villar, Ernesto ; Camerini, Paolo ; Carena, Francesco ; Carena, Wisla ; Castillo Castellanos, Javier Ernesto ; Casula, Ester Anna Rita ; Catanescu, Vasile Ioan ; Cavicchioli, Costanza ; Ceballos Sanchez, Cesar ; Čepila, Jan ; Cerello, Piergiorgio ; Chang, Beomsu ; Chapeland, Sylvain ; Charvet, Jean-Luc Fernand ; Chattopadhyay, Subhasis ; Chattopadhyay, Sukalyan ; Chelnokov, Volodymyr ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Choudhury, Subikash ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Chung, Suh-Urk ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Colamaria, Fabio Filippo ; Colella, Domenico ; Collu, Alberto ; Colocci, Manuel ; Conesa Balbastre, Gustavo ; Conesa Del Valle, Zaida ; Connors, Megan Elizabeth ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortese, Pietro ; Cortes Maldonado, Ismael ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Crochet, Philippe ; Cruz Albino, Rigoberto ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; Dainese, Andrea ; Dang, Ruina ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Das, Kushal ; Das, Supriya ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; Delagrange, Hugues ; Deloff, Andrzej ; Denes, Ervin Sandor ; D’Erasmo, Ginevra ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; De Rooij, Raoul Stefan ; Diaz Corchero, Miguel Angel ; Dietel, Thomas ; Dillenseger, Pascal ; Divià, Roberto ; Di Bari, Domenico ; Di Liberto, Sergio ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domenicis Gimenez, Diogenes ; Donigus, Benjamin ; Dordic, Olja ; Dorheim, Sverre ; Dubey, Anand Kumar ; Dubla, Andrea ; Ducroux, Laurent ; Dupieux, Pascal ; Dutt Mazumder, Abhee Kanti ; Hilden, Timo Eero ; Ehlers Iii, Raymond James ; Elia, Domenico ; Engel, Heiko ; Erazmus, Barbara Ewa ; Erdal, Hege Austrheim ; Eschweiler, Dominic ; Espagnon, Bruno ; Esposito, Marco ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evdokimov, Sergey ; Fabris, Daniela ; Faivre, Julien ; Falchieri, Davide ; Fantoni, Alessandra ; Fasel, Markus ; Fehlker, Dominik ; Feldkamp, Linus ; Felea, Daniel ; Feliciello, Alessandro ; Feofilov, Grigory ; Ferencei, Jozef ; Fernández Téllez, Arturo ; Gonzalez Ferreiro, Elena ; Ferretti, Alessandro ; Festanti, Andrea ; Figiel, Jan ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Floratos, Emmanouil ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Francescon, Andrea ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhoeje, Jens Joergen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gallio, Mauro ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Gao, Chaosong ; Garabatos Cuadrado, Jose ; Garcia-Solis, Edmundo Javier ; Gargiulo, Corrado ; Garishvili, Irakli ; Gerhard, Jochen ; Germain, Marie ; Gheata, Andrei George ; Gheata, Mihaela ; Ghidini, Bruno ; Ghosh, Premomoy ; Ghosh, Sanjay Kumar ; Gianotti, Paola ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gómez Ramírez, Andrés ; González Zamora, Pedro ; Gorbunov, Sergey ; Görlich, Lidia Maria ; Gotovac, Sven ; Graczykowski, Łukasz Kamil ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Ara ; Grigoryan, Smbat ; Grynyov, Borys ; Grion, Nevio ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerzoni, Barbara ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gulkanyan, Hrant ; Gumbo, Mervyn ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Khan, Kamal ; Haake, Rüdiger ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Hanratty, Luke David ; Hansen, Alexander ; Harris, John William ; Hartmann, Helvi ; Harton, Austin Vincent ; Hatzifotiadou, Despina ; Hayashi, Shinichi ; Heckel, Stefan Thomas ; Heide, Markus ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Herrera Corral, Gerardo Antonio ; Hess, Benjamin Andreas ; Hetland, Kristin Fanebust ; Hippolyte, Boris ; Hladkỳ, Jan ; Hristov, Peter ; Huang, Meidana ; Humanic, Thomas J. ; Hussain, Nur ; Hutter, Dirk ; Hwang, Dae Sung ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Innocenti, Gian Michele ; Ionita, Costin ; Ippolitov, Mikhail ; Irfan, Muhammad ; Ivanov, Marian ; Ivanov, Vladimir ; Jacholkowski, Adam Wlodzimierz ; Jacobs, Peter Martin ; Jahnke, Cristiane ; Jang, Haeng Jin ; Janik, Malgorzata Anna ; Pahula Hewage, Sandun ; Jena, Chitrasen ; Jena, Satyajit ; Jiménez Bustamante, Raúl Tonatiuh ; Jones, Peter Graham ; Jung, Hyungtaik ; Jusko, Anton ; Kadyshevskiy, Vladimir ; Kalcher, Sebastian ; Kalinak, Peter ; Kalweit, Alexander Philipp ; Kamin, Jason Adrian ; Kang, Ju Hwan ; Kaplin, Vladimir ; Kar, Somnath ; Karasu Uysal, Ayben ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, Darius Laurens D. ; Khan, Mohammed Mohisin ; Khan, Palash ; Khan, Shuaib Ahmad ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Do Won ; Kim, Dong Jo ; Kim, Jinsook ; Kim, Mimae ; Kim, Minwoo ; Kim, Se Yong ; Kim, Taesoo ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kiss, Gabor ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein-Bösing, Christian ; Kluge, Alexander ; Knichel, Michael Linus ; Knospe, Anders Garritt ; Kobdaj, Chinorat ; Varga-Kofarago, Monika ; Köhler, Markus Konrad ; Kollegger, Thorsten ; Kolozhvari, Anatoly ; Kondratev, Valerii ; Kondratyeva, Natalia ; Konevskikh, Artem ; Kovalenko, Vladimir ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kral, Jiří ; Králik, Ivan ; Kravčáková, Adela ; Křelina, Michal ; Kretz, Matthias ; Krivda, Marian ; Krizek, Filip ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucera, Vit ; Kucheryaev, Yury ; Kugathasan, Thanushan ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kulakov, Igor ; Kumar, Jitendra ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kweon, Min Jung ; Kwon, Youngil ; Ladron de Guevara, Pedro ; Lagana Fernandes, Caio ; Lakomov, Igor ; Langoy, Rune ; Lara Martinez, Camilo Ernesto ; Lardeux, Antoine Xavier ; Lattuca, Alessandra ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lea, Ramona ; Leardini, Lucia ; Lee, Graham Richard ; Legrand, Iosif ; Lehnert, Joerg Walter ; Lemmon, Roy Crawford ; Lenti, Vito ; Leogrande, Emilia ; Leoncino, Marco ; Leon Monzon, Ildefonso ; Lévai, Peter ; Li, Shuang ; Lien, Jørgen André ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Ljunggren, Hans Martin ; Lodato, Davide Francesco ; Lønne, Per-Ivar ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohner, Daniel ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Lu, Xianguo ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Rongrong ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, Durga Prasad ; Mahmood, Sohail Musa ; Maire, Antonin ; Majka, Richard Daniel ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Malinina, Liudmila ; Mal’Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Marchisone, Massimiliano ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marin, Ana Maria ; Markert, Christina ; Marquard, Marco ; Martashvili, Irakli ; Martin, Nicole Alice ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; García Martínez, Ginés ; Martin Blanco, Javier ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Matyja, Adam Tomasz ; Mayer, Christoph ; Mazer, Joel Anthony ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mercado Pérez, Jorge ; Meres, Michal ; Miake, Yasuo ; Mikhaylov, Konstantin ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Mishra, Aditya Nath ; Miśkowiec, Dariusz Czesław ; Mitra, Jubin ; Mitu, Ciprian Mihai ; Mlynarz, Jocelyn ; Mohammadi, Naghmeh ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morreale, Astrid ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Muhlheim, Daniel ; Muhuri, Sanjib ; Mukherjee, Maitreyee ; Muller, Hans ; Gameiro Munhoz, Marcelo ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Nayak, Kishora ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nedosekin, Alexander ; Nicassio, Maria ; Niculescu, Mihai ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, Bjorn Steven ; Noferini, Francesco ; Nomokonov, Petr V. ; Nooren, Gerardus ; Norman, Jaime ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Oeschler, Helmut ; Oh, Saehanseul ; Oh, Sun Kun ; Okatan, Ali ; Oláh, László ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Onderwaater, Jacobus ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Oskarsson, Anders Nils Erik ; Otwinowski, Jacek Tomasz ; Oyama, Ken ; Özdemir, Mahmut ; Sahoo, Pragati ; Pachmayer, Yvonne C. ; Pachr, Milos ; Pagano, Paola ; Paic, Guy ; Painke, Florian ; Pajares Vales, Carlos ; Pal, Susanta Kumar ; Palmeri, Armando ; Pant, Divyash ; Papikyan, Vardanush ; Pappalardo, Giuseppe Salvatore ; Pareek, Pooja ; Park, WooJin ; Parmar, Sonia ; Passfeld, Annika ; Patalakha, Dmitry ; Paticchio, Vincenzo ; Paul, Biswarup ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Pereira da Costa, Hugo Denis Antonio ; Pereira De Oliveira Filho, Elienos ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Pesci, Alessandro ; Peskov, Vladimir ; Pestov, Yury N. ; Petráček, Vojtech ; Petran, Michal ; Petris, Mariana ; Petrovici, Mihai A. ; 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The ALICE collaboration at the LHC reports measurement of the inclusive production cross section of electrons from semi-leptonic decays of beauty hadrons with rapidity |y|<0.8 and transverse momentum 1<pT<10 GeV/c, in pp collisions at s√= 2.76 TeV. Electrons not originating from semi-electronic decay of beauty hadrons are suppressed using the impact parameter of the corresponding tracks. The production cross section of beauty decay electrons is compared to the result obtained with an alternative method which uses the distribution of the azimuthal angle between heavy-flavour decay electrons and charged hadrons. Perturbative QCD calculations agree with the measured cross section within the experimental and theoretical uncertainties. The integrated visible cross section, σb→e=3.47±0.40(stat)+1.12−1.33(sys)±0.07(norm)μb, was extrapolated to full phase space using Fixed Order plus Next-to-Leading Log (FONLL) predictions to obtain the total bb¯ production cross section, σbb¯=130±15.1(stat)+42.1−49.8(sys)+3.4−3.1(extr)±2.5(norm)±4.4(BR)μb.