Universitätspublikationen
Refine
Year of publication
- 2015 (1739) (remove)
Document Type
- Article (603)
- Doctoral Thesis (187)
- Working Paper (169)
- Contribution to a Periodical (164)
- Book (159)
- Report (157)
- Part of Periodical (124)
- Review (70)
- Preprint (55)
- Conference Proceeding (22)
Language
- English (863)
- German (835)
- Spanish (14)
- Italian (11)
- Portuguese (11)
- French (3)
- Multiple languages (1)
- Russian (1)
Is part of the Bibliography
- no (1739)
Keywords
- Islamischer Staat (34)
- IS (25)
- Terrorismus (23)
- Deutschland (16)
- Dschihadismus (13)
- Syrien (12)
- Terror (11)
- Irak (10)
- Islamismus (10)
- Salafismus (10)
Institute
- Präsidium (336)
- Medizin (252)
- Gesellschaftswissenschaften (230)
- Physik (184)
- Wirtschaftswissenschaften (149)
- Exzellenzcluster Die Herausbildung normativer Ordnungen (116)
- Center for Financial Studies (CFS) (115)
- Biowissenschaften (99)
- Informatik (96)
- Frankfurt Institute for Advanced Studies (FIAS) (95)
- Sustainable Architecture for Finance in Europe (SAFE) (93)
- House of Finance (HoF) (76)
- Biochemie und Chemie (74)
- Geschichtswissenschaften (74)
- Geowissenschaften (53)
- Neuere Philologien (50)
- Rechtswissenschaft (48)
- Institut für Wirtschaft, Arbeit, und Kultur (IWAK) (43)
- Philosophie (41)
- Kulturwissenschaften (39)
- Pharmazie (35)
- Senckenbergische Naturforschende Gesellschaft (35)
- Biodiversität und Klima Forschungszentrum (BiK-F) (29)
- Institut für Sozialforschung (IFS) (27)
- Psychologie (27)
- E-Finance Lab e.V. (25)
- Institut für Ökologie, Evolution und Diversität (25)
- Erziehungswissenschaften (22)
- Institut für sozial-ökologische Forschung (ISOE) (17)
- Institute for Monetary and Financial Stability (IMFS) (16)
- Universitätsbibliothek (14)
- Evangelische Theologie (13)
- Geographie (13)
- Sportwissenschaften (13)
- Exzellenzcluster Makromolekulare Komplexe (11)
- Sprachwissenschaften (10)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (9)
- Biochemie, Chemie und Pharmazie (8)
- Georg-Speyer-Haus (8)
- Mathematik (8)
- Sprach- und Kulturwissenschaften (8)
- MPI für Hirnforschung (6)
- Sonderforschungsbereiche / Forschungskollegs (6)
- Institute for Law and Finance (ILF) (5)
- Philosophie und Geschichtswissenschaften (5)
- Hessische Stiftung für Friedens- und Konfliktforschung (HSFK) (4)
- Informatik und Mathematik (3)
- Katholische Theologie (3)
- LOEWE-Schwerpunkt Außergerichtliche und gerichtliche Konfliktlösung (3)
- Starker Start ins Studium: Qualitätspakt Lehre (3)
- Centre for Drug Research (2)
- Deutsches Institut für Internationale Pädagogische Forschung (DIPF) (2)
- Forschungskolleg Humanwissenschaften (2)
- Gleichstellungsbüro (2)
- Hochschulrechenzentrum (2)
- Interdisziplinäres Zentrum für Ostasienstudien (IZO) (2)
- MPI für Biophysik (2)
- Museum Giersch der Goethe Universität (2)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (2)
- Zentrum für Interdisziplinäre Afrikaforschung (ZIAF) (2)
- Akademie für Bildungsforschung und Lehrerbildung (bisher: Zentrum für Lehrerbildung und Schul- und Unterrichtsforschung) (1)
- Center for Membrane Proteomics (CMP) (1)
- Cornelia Goethe Centrum für Frauenstudien und die Erforschung der Geschlechterverhältnisse (CGC) (1)
- ELEMENTS (1)
- Ernst Strüngmann Institut (1)
- Europäische Akademie der Arbeit in der Universität Frankfurt am Main (1)
- Geowissenschaften / Geographie (1)
- LOEWE-Schwerpunkt für Integrative Pilzforschung (1)
- MPI für empirische Ästhetik (1)
- Universität des 3. Lebensalters e.V. (1)
Background: The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor formation and to decipher novel access points for cancer therapy. However, cellular in vitro assays, which rely on monolayer cultures of mammalian cell lines, neglect the three-dimensional architecture of a tumor, thus limiting their validity for the in vivo situation.
Methods: Three-dimensional in vivo-like tumor spheroid were established from human cervical carcinoma cell lines as proof of concept to investigate infiltration and cytotoxicity of NK cells in a 96-well plate format, which is applicable for high-throughput screening. Tumor spheroids were monitored for NK cell infiltration and cytotoxicity by flow cytometry. Infiltrated NK cells, could be recovered by magnetic cell separation.
Results: The tumor spheroids were stable over several days with minor alterations in phenotypic appearance. The tumor spheroids expressed high levels of cellular ligands for the natural killer (NK) group 2D receptor (NKG2D), mediating spheroid destruction by primary human NK cells. Interestingly, destruction of a three-dimensional tumor spheroid took much longer when compared to the parental monolayer cultures. Moreover, destruction of tumor spheroids was accompanied by infiltration of a fraction of NK cells, which could be recovered at high purity.
Conclusion: Tumor spheroids represent a versatile in vivo-like model system to study cytotoxicity and infiltration of immune cells in high-throughput screening. This system might proof useful for the investigation of the modulatory potential of soluble factors and cells of the tumor microenvironment on immune cell activity as well as profiling of patient-/donor-derived immune cells to personalize cellular immunotherapy.
Background: Plant hormones are well known regulators which balance plant responses to abiotic and biotic stresses. We investigated the role of abscisic acid (ABA) in resistance of barley (Hordeum vulgare L.) against the plant pathogenic fungus Magnaporthe oryzae.
Results: Exogenous application of ABA prior to inoculation with M. oryzae led to more disease symptoms on barley leaves. This result contrasted the finding that ABA application enhances resistance of barley against the powdery mildew fungus. Microscopic analysis identified diminished penetration resistance as cause for enhanced susceptibility. Consistently, the barley mutant Az34, impaired in ABA biosynthesis, was less susceptible to infection by M. oryzae and displayed elevated penetration resistance as compared to the isogenic wild type cultivar Steptoe. Chemical complementation of Az34 mutant plants by exogenous application of ABA re-established disease severity to the wild type level. The role of ABA in susceptibility of barley against M. oryzae was corroborated by showing that ABA application led to increased disease severity in all barley cultivars under investigation except for the most susceptible cultivar Pallas. Interestingly, endogenous ABA concentrations did not significantly change after infection of barley with M. oryzae.
Conclusion: Our results revealed that elevated ABA levels led to a higher disease severity on barley leaves to M. oryzae. This supports earlier reports on the role of ABA in enhancing susceptibility of rice to the same pathogen and thereby demonstrates a host plant-independent function of this phytohormone in pathogenicity of monocotyledonous plants against M. oryzae.
Background: High reproducibility of LV mass and volume measurement from cine cardiovascular magnetic resonance (CMR) has been shown within single centers. However, the extent to which contours may vary from center to center, due to different training protocols, is unknown. We aimed to quantify sources of variation between many centers, and provide a multi-center consensus ground truth dataset for benchmarking automated processing tools and facilitating training for new readers in CMR analysis.
Methods: Seven independent expert readers, representing seven experienced CMR core laboratories, analyzed fifteen cine CMR data sets in accordance with their standard operating protocols and SCMR guidelines. Consensus contours were generated for each image according to a statistical optimization scheme that maximized contour placement agreement between readers.
Results: Reader-consensus agreement was better than inter-reader agreement (end-diastolic volume 14.7 ml vs 15.2–28.4 ml; end-systolic volume 13.2 ml vs 14.0–21.5 ml; LV mass 17.5 g vs 20.2–34.5 g; ejection fraction 4.2 % vs 4.6–7.5 %). Compared with consensus contours, readers were very consistent (small variability across cases within each reader), but bias varied between readers due to differences in contouring protocols at each center. Although larger contour differences were found at the apex and base, the main effect on volume was due to small but consistent differences in the position of the contours in all regions of the LV.
Conclusions: A multi-center consensus dataset was established for the purposes of benchmarking and training. Achieving consensus on contour drawing protocol between centers before analysis, or bias correction after analysis, is required when collating multi-center results.
We analyze the macroeconomic implications of increasing the top marginal income tax rate using a dynamic general equilibrium framework with heterogeneous agents and a fiscal structure resembling the actual U.S. tax system. The wealth and income distributions generated by our model replicate the empirical ones. In two policy experiments, we increase the statutory top marginal tax rate from 35 to 70 percent and redistribute the additional tax revenue among households, either by decreasing all other marginal tax rates or by paying out a lump-sum transfer to all households. We find that increasing the top marginal tax rate decreases inequality in both wealth and income but also leads to a contraction of the aggregate economy. This is primarily driven by the negative effects that the tax change has on top income earners. The aggregate gain in welfare is sizable in both experiments mainly due to a higher degree of distributional equality.
This paper looks into the specific influence that the European banking union will have on (future) bank client relationships. It shows that the intended regulatory influence on market conditions in principle serves as a powerful governance tool to achieve financial stability objectives.
From this vantage, it analyzes macro-prudential instruments with a particular view to mortgage lending markets – the latter have been critical in the emergence of many modern financial crises. In gauging the impact of the new European supervisory framework, it finds that the ECB will lack influence on key macro-prudential tools to push through more rigid supervisory policies vis-à-vis forbearing national authorities.
Furthermore, this paper points out that the current design of the European bail-in tool supplies resolution authorities with undue discretion. This feature which also afflicts the SRM imperils the key policy objective to re-instill market discipline on banks’ debt financing operations. The latter is also called into question because the nested regulatory technique that aims at preventing bail-outs unintendedly opens additional maneuvering space for political decision makers.
In Absatz 3 des Artikel 136 des Vertrags über die Arbeitsweise der EU (AEUV) wurde für die Verwendung von ESM Geldern festgelegt, dass diese nur dann zur Gewährung von Finanzhilfen verwendet werden dürfen, wenn „... dies unabdingbar ist, um die Stabilität des Euro-Währungsgebiets insgesamt zu wahren." Im vorliegenden Artikel argumentiert Alfons Weichenrieder, dass die nach dem griechischen Referendum entstandene Situation, die Stabilität des “Euro-Währungsgebiets insgesamt" nicht bedroht, so dass die Vergabe von neuen Krediten, zumal diese voraussichtlich unter weichen und im Zweifel nicht durchsetzbaren Auflagen vergeben würden, ein offensichtlicher Verstoß gegen die Grundlagen des ESM wäre.
In this statement the European Shadow Financial Regulatory Committee (ESFRC) is advocating a conditional relief of Greek’s government debt based on Greece meeting certain targets for structural economic reforms in areas such as its labor market and pensions sector.The authors argue that the position of the European institutions that debt relief for Greece cannot be part of an agreement is based on the illusion that Greece will be able to service its sovereign debt and reduce its debt overhang after implementing a set of fiscal and structural reforms. However, the Greek economy would need to grow at an unrealistig level to achieve debt sustainability soley on the basis of reforms.The authors therefore view a substantial debt relief as inevitable and argue that three questions must be resolved urgently, in order to structure debt relief adequately: First, which groups must accept losses associated with debt relief. Second, how much debt relief should be offered. Third, under what conditions should relief be offered.
In light of the failed negotiations with Greece, Jan Krahnen argues that an effective reform agenda for Greece can only be designed by the elected government. Fundamental reforms will take time to take full effect and euro area member states will, in the meantime, have to offer Greece a basic level of economic security.
Krahnen demands that policy makers and the professional public involved view the Greek crisis as an opportunity to take the next necessary steps to formulate a reform agenda for the European Monetary Union. A community of supranational and non-party researchers and intellectuals could take the initiative and in a structured process develop a trustworthy and realistic concept that drafts the next big step towards a political union of Europe, including elements of a fiscal union.
Mit Blick auf die gescheiterten Verhandlungen mit Griechenland, argumentiert Jan Krahnen im vorliegenden Policy Beitrag, dass eine zielführende Reformagenda nur von der gewählten Regierung Griechenlands formuliert werden kann. Die Euro-Staaten müssten Griechenland für die Zeitdauer einer Restrukturierungszeit eine Grundsicherung zusagen. Die EU-Staaten fordert Krahnen dazu auf, aus der Griechenlandkrise die notwendigen Konsequenzen zu ziehen. Auch die Eurozone brauche eine effektive Reformagenda. Die Verschuldungsdynamik innerhalb der Währungsunion, deren Auswüchse am Beispiel Griechenlands besonders deutlich werden, könne bei fehlendem guten Willen nur durch eine politische Union und eine in sie eingebettete Fiskalunion aufgelöst werden. Krahnen argumentiert, dass ein Weiterverhandeln über Restrukturierungsauflagen aus der derzeitigen verfahrenen Situation nicht herausführen wird. Entscheidend sei, ein mehr oder weniger umfassendes Paket zu schnüren, das Elemente eines teilweisen internationalen Haftungsverbunds mit Elementen eines partiellen nationalen Souveränitätsverzichts verbindet.