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Glanzvolle Talare, fliegende Gelehrtenhüte – oder doch lieber ein bescheidener Umtrunk im engeren Kreise? Eine Standardantwort darauf, ob und wie die Absolventen eines Jahrganges zu verabschieden seien, gibt es nicht. Die Tendenz ist jedoch deutlich: Nach Jahren des Lernens, Forschens und Experimentierens – und vor allem nach bestandenen Prüfungsstrapazen – wünschen sich viele Absolventen und Dozenten ein passendes Abschiedsritual. Wie das aussehen kann, davon geben die 16 Fachbereichen der Goethe-Universität ein facettenreiches Bild: Bedingt durch die jeweilige Fächerkultur, aber auch durch Struktur und Ausstattung, oszilliert das Abschiedsritual zwischen prosaisch und pompös.
»Eine unbezahlbare Erfahrung« : Studentica – Ein Online-Netzwerk von Studierenden für Studierende
(2015)
In der Dissertation wird das Antwortverhalten von Kindern bei der Koordination von Theorie und Evidenz untersucht. Diese Fähigkeit ist besonders beim naturwissenschaftlichen Lernen relevant. Dazu werden zwei Studien vorgestellt. In der ersten Studie, der Querschnittsstudie wird das Antwortverhalten von Kindern im Alter von fünf bis neun Jahren am Beispiel der Leitfrage: „Warum springt ein Ball?“ untersucht. Verschiedene Vermutungen wie zum Beispiel „Dinge, die rund sind, springen“, werden geprüft. In der zweiten Studie, dem Kernstück der Arbeit werden zwei Fördermaßnahmen zum Training der Koordination von Theorie und Evidenz bei fünf- bis sechsjährigen Kindern vorgestellt.
CLOUD COMPUTING PROMISES ENHANCED FLEXIBILITY AND SUBSTANTIAL ECONOMIC
BENEFITS THROUGH THE ON-DEMAND LEASE OF IT RESOURCES. THESE TWO ASPECTS ARE STRONGLY INFLUENCED BY THE PRICING OF CLOUD RESOURCES. BASED ON A SAMPLE OF 48 INFRASTRUCTURE PROVIDERS, WE EXAMINE CURRENT PRICING SCHEMES IN THE CLOUD MARKET FROM A USER PERSPECTIVE.
BANK INSTABILITY SEEMINGLY COULD PUSH BORROWERS TO USE CROWDFUNDING AS A SOURCE OF EXTERNAL FINANCE. WE CONSTRUCT A NOVEL, HAND-COLLECTED DATA SET OF VENTURES' USES OF EQUITY CROWDFUNDING IN GERMANY, THEIR RELATIONSHIPS WITH BANKS, AND VARIOUS VENTURE TRAITS SINCE 2011. BY OBSERVING VENTUREBANK RELATIONSHIPS, WE CAN IDENTIFY IF VENTURES CONNECTED TO SHOCKED BANKS ARE MORE LIKELY TO USE CROWDFUNDING IN AN ATTEMPT TO SUBSTITUTE FOR CONTRACTING BANK CREDIT SUPPLY. OUR RESULTS SHOW THAT CROWDFUNDING IS SIGNIFICANTLY MORE LIKELY FOR NEW VENTURES THAT INTERACT WITH STRESSED BANKS. INNOVATIVE FUNDING SOURCES ARE THUS PARTICULARLY RELEVANT IN TIMES OF STRESS AMONG CONVENTIONAL FINANCIERS. BUT CROWDFUNDED VENTURES ARE GENERALLY ALSO MORE OPAQUE AND RISKY THAN NEW VENTURES THAT DO NOT USE CROWDFUNDING.
Analyzing the relationship between differentiated online sentiment and company-specific stock prices
(2015)
PRACTITIONERS AND RESEARCHERS ALIKE INCREASINGLY USE SOCIAL MEDIA MESSAGES AS AN ADDITIONAL SOURCE OF INFORMATION WHEN DEALING WITH STOCKS. BASED ON EMOTION THEORY AND AN ESTABLISHED SENTIMENT LEXICON, WE DEVELOP AND APPLY AN OPEN SOURCE DICTIONARY FOR THE ANALYSIS OF SEVEN DIFFERENT EMOTIONS IN 5.5 MILLION TWITTER MESSAGES ON 33 S&P 100 COMPANIES. WE FIND VARYING EXPLANATORY POWER OF DIFFERENT EMOTIONS (ESP. HAPPINESS, AND DEPRESSION) FOR COMPANY-SPECIFIC STOCK PRICE MOVEMENTS OVER A PERIOD OF THREE MONTHS.
Encouraging growth funding
(2015)
DESPITE AMPLE EVIDENCE THAT CUSTOMERS EXHIBIT HIGHER DISCOUNT RATES THAN FIRMS, IT IS NOT CLEAR HOW DIFFERENCES IN DISCOUNT RATES AFFECT OPTIMAL PRICES, PROFITS, AND WELFARE OF COMPLEMENTARY PRODUCTS (WHICH COULD BE GOODS OR SERVICES). WE SHOW FOR COMPLEMENTARY PROUCTS THAT HIGHER DISCOUNT RATES OF CUSTOMERS DO NOT INCREASE PROFIT OR CONSUMER SURPLUS. FIRMS, INCLUDING BANKS, WOULD BE ADVISED TO SEEK TO REDUCE EXCESSIVE DISCOUNT RATES AMONG CONSUMERS.
WE DECOMPOSE INDIVIDUAL INVESTORS’ PORTFOLIO RETURNS INTO PASSIVE BENCHMARK RETURNS, ACTIVE SECURITY SELECTION RETURNS, AND ACTIVE MARKET TIMING RETURNS. FOR THE AVERAGE INVESTOR IN OUR SAMPLE, PASSIVE BENCHMARK RETURNS EXPLAIN SOME 40% OF VARIATION IN LONGITUDINAL PORTFOLIO RETURNS, SECURITY SELECTION EXPLAINS AN ADDITIONAL 50%, AND MARKET TIMING PLAYS ONLY A MINOR ROLE. THIS STANDS IN STARK CONTRAST TO EARLIER RESULTS ON INSTITUTIONAL INVESTORS WHERE PASSIVE BENCHMARK RETURNS (REFLECTING DIFFERENT ASSET ALLOCATION STRATEGIES) EXPLAIN OVER 90%. THE PREDOMINANCE OF SECURITY SELECTION COMES AT A COST FOR INDIVIDUAL INVESTORS: INVESTORS FROM THE HIGHEST QUINTILE IN TERMS OF SECURITY SELECTION ACTIVITY UNDERPERFORM THEIR PEERS FROM THE LOWEST QUINTILE BY MORE THAN 10 PERCENTAGE POINTS PER YEAR. TRANSACTION COSTS EXPLAIN ONLY PART OF THIS UNDERPERFORMANCE. THE LESS INVESTORS DIVERSIFY, THE WORSE THEY DO.
TO DERIVE OPTIMAL ORDER EXECUTION STRATEGIES THAT STRIVE TO MINIMIZE TRANSACTION COSTS, INVESTORS AS WELL AS AUTOMATED TRADING ENGINES MUST BE ABLE TO ANTICIPATE CHANGES IN THE AVAILABLE MARKET LIQUIDITY. BASED ON AN EVENT STUDY ON THE LIQUIDITY IMPACT OF AD-HOC DISCLOSURES, WE PROPOSE A NOVEL IT ARTIFACT THAT ALLOWS AUTOMATED TRADING ENGINES TO APPROPRIATELY REACT TO NEWS-RELATED LIQUIDITY SHOCKS. FURTHERMORE, WE PROVIDE A SIMULATIONBASED EVALUATION THAT SHOWS ITS ECONOMIC RELEVANCE.
THE SPEED OF TRADING, AND IN PARTICULAR HIGH-FREQUENCY TRADING, IS ONE OF THE MOSTLY DEBATED ISSUES AMONG REGULATORS AND MARKET PARTICIPANTS. NEVERTHELESS, SEVERAL ACADEMIC STUDIES HAVE SHOWN THAT HIGH-FREQUENCY TRADERS USING LOW-LATENCY INFRASTRUCTURE PROVIDE ADDITIONAL LIQUIDITY THEREBY REDUCING TRANSACTION COSTS IN ORDINARY TIMES OF TRADING. WE STUDY WHETHER HIGH-FREQUENCY TRADERS ALSO CONTRIBUTE TO THE RECONSTRUCTION OF THE ORDER BOOK AFTER LIQUIDITY SHOCKS CAUSED BY LARGE ORDERS.
WHILE CLOUD MARKETS PROMISE UNLIMITED RESOURCE SUPPLIES, INDIVIDUAL PROVIDERS MIGHT BE UNABLE TO OFFER SUFFICIENT PHYSICAL CAPACITY TO SERVE LARGE CUSTOMERS. A SOLUTION IS TO FORM CLOUD COLLABORATIONS, IN WHICH MULTIPLE CLOUD PROVIDERS UNITE FORCES IN ORDER TO CONJOINTLY OFFER CAPACITIES WITHIN CLOUD MARKETS. QUALITY OF SERVICE (QOS) AND SECURITY ASPECTS ARE THE PRIMARY CONSIDERATIONS IN BUILDING SUCH COLLABORATIONS. THIS RESEARCH REPORT PRESENTS A CORRESPONDING OPTIMIZATION APPROACH FOR THE SELECTION OF COLLABORATIVE CLOUD PROVIDERS UNDER CONSIDERATION OF FULFILLMENT OF CLOUD USERS’ QOS AND SECURITY REQUIREMENTS.
Adorno’s negative dialectics wants to free the thought from the dictates of the system, taking position against the illusion to grasp the essence of reality by logic. Against that false idea of totality, Adorno devises a philosophy of fragment, a logic of disgregation that presupposes a different concept of totality: a fragmented, scattered and conflicting wholeness. The anti systematic thinking of Adorno is configured, however, as a systematic rejection of any systematic formulation: philosophy can at most claiming a pretension to truth by the practice of interpretation. A dialectic configuration of fragments of totality is at stake here: so, the arrangement of such fragments can both produce an image of reality endowed with meaning and also unfold through heterogeneous combinations that are not definitive, but always renewable from time to time. In Adorno’s reflection are so expressed two different instances which are complementary at the same time: on the one hand it represents the critical and negative element against the system and its hybris, on the other hand it expresses the need of the thought to go beyond and overcome that fragmentation, showing how the need of unity of the system is a need of the thought in itself.
Die Zahl der Verfahren und der Sterilisationen nach dem Gesetz zur Verhütung erbkranken Nachwuchses
(2015)
In dem Buch wird die Zahl der Verfahren nach dem Gesetz zur Verhütung erbkranken Nachwuchses von 1934 bis 1945 (nach Hochrechnung) im "Altreich" auf ca. 436.000 geschätzt. Durchgeführt wurden laut Schätzung im "Altreich" ca. 294.000 Sterilisationen. Dazu kommen noch ca. 10.000 bis 20.000 Sterilisationen in den "angeschlossenen" oder annektierten Gebieten bis 1945.
Controlling magnetic properties on the nanometer-scale is essential for basic research in micro-magnetism and spin-dependent transport, as well as for various applications such as magnetic recording, imaging and sensing. This has been accomplished to a very high degree by means of layered heterostructures in the vertical dimension. Here we present a complementary approach that allows for a controlled tuning of the magnetic properties of Co/Pt heterostructures on the lateral mesoscale. By means of in situ post-processing of Pt- and Co-based nano-stripes prepared by focused electron beam induced deposition (FEBID) we are able to locally tune their coercive field and remanent magnetization. Whereas single Co-FEBID nano-stripes show no hysteresis, we find hard-magnetic behavior for post-processed Co/Pt nano-stripes with coercive fields up to 850 Oe. We attribute the observed effects to the locally controlled formation of the CoPt L10 phase, whose presence has been revealed by transmission electron microscopy.
South African Journal of Industrial and Organisational Psychology: Annual editorial overview 2015
(2015)
Orientation: Employees’ perceptions of their leaders’ behaviour play a role in creating empowering environments where employees are willing to do more than what is expected, with retention of employees as a result. Research purpose: The aim of this study was to theoretically conceptualise and empirically determine the relationships between employees’ perception of their leaders’ empowering behaviour, psychological empowerment, organisational citizenship behaviours and intention to leave within a manufacturing division of an organisation. Motivation for the study: In the ever-changing work environment, organisations must capitalise on their human capital in order to maintain competitiveness. It is therefore important to identify the role of employees’ perception of leadership in contributing to the establishment of an environment where employees feel empowered, are willing to do more than what is expected and want to stay in the organisation. Research design, approach and method: A non-experimental, cross-sectional survey design was used. The total population (N = 300) employed at the manufacturing division was targeted. Two hundred completed questionnaires were obtained. The Leader Empowering Behaviour Questionnaire, Measuring Empowerment Questionnaire, Organisational Citizenship Behaviour Questionnaire and Intention to Leave Scale were administered. Main findings: Employees’ perception of their leaders’ empowering behaviour (keeping employees accountable, self-directed decision-making and people development), psychological empowerment (attitude and influence) and organisational citizenship behaviours (loyalty, deviant behaviour and participation) predict intention to leave the organisation. Practical/managerial implications: Organisations should foster the elements of a positive organisation, in this case leader empowering behaviours, if they want to retain their employees. Contribution/value-add: The results of this research contribute to scientific knowledge about the positive effects of employees experiencing their leaders as empowering.
Psychological ownership is a cognitive–affective construct based on individuals’ feelings of possessiveness towards and of being psychologically tied/attached to objects that are material (e.g. tools or work) and immaterial (e.g. ideas or workspace) in nature. Research suggests that psychological ownership could be influenced by various individual, organisational and contextual factors. The South African Employment Equity Act, which was implemented to grant equitable opportunities to previously disadvantaged employees, could be a significant contextual factor affecting psychological ownership, due to perceptions associated with inequality. Ethnicity may also act as a moderator for the relationship between perceptions of employment equity and psychological ownership. The objective of this study was to investigate the relationship between employment equity perceptions and psychological ownership and to explore whether ethnicity plays a moderating role in the relationship. A cross-sectional survey design was employed with a purposeful sample of 202 respondents employed in a large South African mining house. Pearson product–moment correlations and structural equation modelling confirmed that employment equity perceptions could predict the five components of psychological ownership. However, the results revealed that ethnicity has no moderating effect on the relationship between perceptions of employment equity and the emergence of psychological ownership. By implication, organisations that seek to retain employees targeted through equity initiatives need to find ways to enhance and develop the psychological ownership of these employees. The research contributes new insights into and knowledge of how contextual factors could influence employees’ psychological ownership.
Nos Mandamentos, Deus proíbe aos homens tanto a feitura de imagens quanto a pronúncia em vão de Seu nome. Há, portanto, limites rígidos entre as esferas do sagrado e do humano. Este artigo examinará paralelos e divergências entre os pensamentos de dois autores que abordaram essa questão a partir de escolas de pensamento distintas: o filósofo neomarxista judeu Theodor Adorno e o teólogo luterano Eberhard Jüngel.
Sublimity, negativity, and architecture. An essay on negative architecture through Kant to Adorno
(2015)
Architecture defines and consumes people. It exposes them to a multitude of varieties of different aesthetic engagements. Architecture becomes a lived experience. However, this lived experience is always caught in the inner workings of the social and more specifically within cultural ideology. In modern capitalism, culture pervades every aspect of our lives. It shows its presence everywhere from our own homes to the public streets. Culture is everywhere, and architecture is a tool used for both the benefit and detriment of the “culture industry”. Kant speaks of the sublime as a profound moment of reason realizing its ability to overcome its own limits. In this experience is it possible to be completely ravaged and descend into hades and melancholy? Is there a beauty in this descent? More specifically, can architecture become banal or pedestrian, uplifting or depressing? According to Theodor Adorno, our subjectivity is defined by the constant dialectical struggle between freedom and unfreedom (among other things). It is realizing our freedom in the face of our unfreedom that makes us truly able to attain some form of resistance. The sublime experience can be transformed into a spirit of revelation and beautifully allow us to in a way resist the one-dimensional tendencies of modern capitalism. Architecture, which is immersed in our societal being and contributes to many of our own subjective unfreedoms, comes to define our lives as inhabited space. When does architecture produce a sublime experience? Can architecture’s authentic “aura” stand out amongst the reproduced city and produce a sublime feeling that can be a form of resistance against the culture industry? Does Grand Central Terminal provide the key to an architecturally sublime experience? Using dialectical experience and examining the sublime feeling (in a critique of the Kantian sublime) as the key to breaking through the culture industry’s banal architectural hold on our subjectivity, this essay will examine the experience of the sublime as a key to unfolding resistance in the face of the banality of modern architecture in the city and opening our minds to the Great Refusal through the exploration of Grand Central Terminal.
Este trabajo es el resultado de la investigación Capital Humano como factor de crecimiento Económico, en el cual se desarrolla una reflexión crítica sobre la teoría del Capital Humano, el abordaje se hace desde la teoría económica y el análisis tiene como referente los planteamientos de la Escuela de Frankfurt, especialmente en lo que tiene que ver con el uso desde la perspectiva de la racionalidad. Desde el punto de vista metodológico se trata de una investigación cualitativa, basada en un proceso de carácter interpretativo y comprensivo de tipo Histórico Hermenéutico, el método utilizado responde a una finalidad de descripción, interpretación, argumentación, que permitan avanzar hacia la comprensión de las temáticas estudiadas en un proceso dialéctico. Como resultado del proceso investigativo se hace un análisis de la instrumentalización de la educación, la formación, la capacidad de trabajo y el estado de salud del hombre, y aún de su propio ser, las cuales se consideran de la misma naturaleza que una maquina y quedan cosificadas al ser convertidas en mercancías comerciales que se venden en el mercado, lo que determina la posibilidad de colocarle un precio pagado en el mercado a la productividad de un tipo de trabajo determinado, a la acción del propio hombre y el desarrollo de sus capacidades superiores que deberían permitirle contribuir al logro de una sociedad mejor y una vida más digna.
Este artigo analisa a crítica de Adorno à ontologia de Heidegger. Para tal, utiliza como leitmotiv a interpretação heideggeriana de Kant. Procuraremos mostrar que para Adorno a edificação da ontologia fundamental a partir da filosofia de Kant é uma interpretação indevida desta. Por fim, procura apontar uma possível saída na filosofia de Adorno para o problema da necessidade de fundamentação do discurso filosófico. Tal saída passa pela constatação da importância da arte para a construção da universalidade na filosofia.
Desde Dialéctica de la Ilustración hasta Dialéctica negativa, el materialismo filosófico llevado adelante por T. W. Adorno ha ubicado en un lugar central de sus reflexiones la problemática de lo corporal, poniéndolo en discusión directa tanto con el psicoanálisis y su teoría de las pulsiones, así como con las diferentes versiones del idealismo. La reflexión acerca de este ámbito, permitirá exponer tanto el carácter represivo de la sociedad; también, la posibilidad de una ética verdaderamente democrática.
O presente artigo visa a fazer algumas anotações sobre educação, emancipação e crítica social no pensamento de Theodor W. Adorno. Esses temas se relacionam direta e indiretamente nos escritos de Adorno e assinalam a coerência epistemológica da sua teoria crítica em relação a ambos. Desse modo, a questão que colocamos é a seguinte: como compreender a tensão presente entre as necessidades de uma educação para a emancipação e as condições para efetivá-la? Essa questão nos encaminha para outra: é possível relacionar, nos textos adornianos, uma perspectiva de se pensar a educação para a emancipação, articulada a uma crítica social no contexto atual? Primeiramente, fazemos uma breve incursão no que consiste o pensamento contra a barbárie em Adorno, sobretudo, a partir do sentido de Auschwitz como símbolo da relação entre civilização e barbárie que o autor faz. Num segundo momento, nos confrontamos com a questão da formação cultural na Teoria da Semiformação, cujo escopo do texto é apontar os limites da formação cultural e consequentemente os limites da educação no âmbito do capitalismo avançado. Por fim, pretendemos discutir a ideia de "crítica social" em Adorno, articulada aos temas anteriores, isto é, apontar algumas ponderações para uma educação contra a barbárie e a semiformação frentes aos desafios impostos pela sociedade atual.
‘Being with oneself in the other’ is a well-known formula that Hegel uses to characterize the basic relation of subjective freedom. This phrase points to the fact that subjects can only come to themselves if they remain capable of going beyond themselves. This motif also plays a significant role in Hegel’s philosophy of art. The article further develops this motif by exploring the extent to which this polarity of selfhood and otherhood is also characteristic of states of aesthetic freedom. It does not offer an exegesis of Hegel’s writings, but attempts to remain as close as possible to the spirit of Hegel’s philosophy – with some help from Kant and Adorno. The argument begins with some key terms on the general state of subjective freedom in order to distinguish it from the particular role of aesthetic freedom and then, finally, drawing again on Hegel, works out the sense in which aesthetic freedom represents an important variant of freedom.
In my paper, I intend firmly to criticize Taubes' interpretation of Benjamin's Theology as a modern form of Gnosticism (Benjamin as a modern Marcionit). In a positive way, I sustain rather the thesis that Benjamin's Messianism is in close connection with his conception of reason (“the sharpened axe of reason”) and, in particularly, with the paradoxical unity of Mysticism and Enlightenment, which, according to the famous definition of Adorno, distinguishes his thought. As a radically anti-magical and anti-mythical conception of the historical time, Benjamin's Messianism has to be considered as an original synthesis between motifs of the mystical tradition of the Jewish Kabbalah and motifs belonging to the rationalist tradition of the Jewish philosophy. Moving from Cohen's standpoint of a continuity between Maimonides and Kant, I consider therefore the affinity between his messianic conception of history and that of Benjamin. Both, Benjamin and Cohen, share, together with the reference to the a priori of the idea of justice, the reference to the Kantian connection between rationality and hope. Hence originates the non-eschatological Messianism of both. Motives of difference between Cohen and Benjamin’s messianic idea are to be found, conversely, in their different way to consider the idea of "the infinite task" and of its infinite fulfillment in the context of the historical time. Unlike the fundamentally ethical interpretation that Cohen gives of this relationship, Benjamin understands it ontologically in a monadological sense. This explains the constitutive relationship that exists, in Benjamin's philosophy, between Origin, Fragment and Revelation. In the light of this connection, Benjamin's messianic understanding of the historical time exceeds the Scholemian alternative between a restorative and a utopian conception of Messianism. Consequently, the Krausian motto “Ursprung ist das Ziel” (“The Origin is the Goal”) displays its truth in the idea of the messianic fragment or spark.
In the nineties, Habermas redirected his political writings to the post-national constellation (global and European) and the possibilities of a society politically integrated through transnational democracy (or post-national democracy). This thematic reorientation took place on two fronts. The first one is the global transnational democracy, which includes the impacts of the economic globalization on national democracies, as well the proposal for a political Constitution for a pluralistic world society, based on a constitutionalization of international law. The second one is the European transnational democracy, which includes the redefinition of the political profile of European welfare state for an economic liberal profile, as well the paradox of democratic technocracy operated by European institutions and the proposal to overcome the decoupled technocratic policy model. This paper will address only this last topic, describing the reasons of the democratic deficit and the consequent delay of European political Union. Despite numerous reforms, the technocratic policies have not eliminated the discrepancy between centralization and democratization, and mistakenly indicate another direction further reinforcing the problem of European undemocratic institutions. In contrast, Habermas argues that the democratic deficit could only be overcome replacing the technocratic approach by a deeper democratization of European institutions.
El artículo presenta cómo el filósofo alemán Theodor W. Adorno concibe el estado social de la música de la primera mitad del siglo XX. Para ello recurro a
una serie de conceptos utilizados por el autor y cuyas raíces están en el pensamiento filosófico de la modernidad. Con gran influencia de Walter Benjamin, cada concepto en Adorno es una constelación, es decir, una idea que debe ser desarrollada y que al relacionarse con otros conceptos se llega a una interpretación más abarcadora del problema a considerarse. Así pues, divido el escrito en dos partes: uno dedicado al análisis de la ideología y el otro al de reificación. Cada capítulo así mismo está dividido en distintos apartados, con el ánimo de dar una visión más amplia de cómo Adorno entendió el problema de la experiencia musical para al final dar cuenta de la importancia del pensamiento estético de Adorno al compararlo con otros autores que reflexionaron sobre el mismo tema.
Para responder a la pregunta: ¿Qué es la literatura?, Sartre propone el concepto de unidad como su característica exclusiva que la relaciona con la sociedad por la vía del compromiso. Se analiza tal exclusividad, así como las objeciones de Adorno a la noción de compromiso, para encontrar, en medio de sus grandes diferencias, algunas afinidades que permitan establecer las relaciones entre la literatura y la sociedad.
Il saggio propone una ricostruzione critica della concezione di impegno e di politicità della letteratura formulate da Brecht e da Adorno. Concezioni opposte che possono essere considerate le formulazioni più efficaci delle due posizioni predominanti nel dibattito estetico del Novecento.
Adorno fonda la politicità della letteratura sulla sua autonomia e sulla liberazione della forma. La politicità dell’arte scaturisce per lui dal rifiuto della discorsività, dalla aggressiva sottrazione del senso, dalla esposizione del negativo. La sua è una concezione dell’impegno elitaria che subordina il discorso artistico a quello filosofico. Brecht fonda la possibilità politiche della letteratura sulla consapevolezza della medialità dell’esperienza. Può essere rivoluzionario solo l’autore che ha riflettuto sulle mediali condizioni della propria produzione e produce opere che non sono espressione di una soggettività ma lavoro alla trasformazione e al cambiamento di funzione dei dispositivi mediali e delle istituzioni in cui agisce.
Background: Curcuminoids (curcumin, demethoxycurcumin, bis-demethoxycurcumin) are lipophilic polyphenols thought to be effective in the prevention and treatment of neurodegenerative disorders, of which mitochondrial dysfunction is a prominent feature. In particular, older people may thus benefit from increasing their curcuminoid intake. However until now, it is not investigated if there exist age differences in the bioavailability of curcuminoids and therefore, it is unclear if curcumin doses have to be adjusted to age. Thus, we explored if the tissue concentrations and biological activities of curcuminoids are affected by age.
Methods: We investigated age-differences in the bioavailability and tissue distribution of curcuminoids and mitochondrial function in 3- and 18-months old mice fed a control diet or identical diets fortified with 500 or 2000 mg curcuminoids/kg for 3 weeks. Therefore, we measured curcuminoid concentrations in plasma, liver, kidney, and brain, basal and stress-induced levels of adenosine triphosphate (ATP) and mitochondrial membrane potential (MMP) in dissociated brain cells and citrate synthase activity of isolated mitochondria.
Results: Plasma but not liver and kidney curcuminoid concentrations were significantly higher in older mice. Age did not affect ATP concentrations and MMP in dissociated brain cells. After damaging cells with nitrosative stress, dissociated brain cells from old mice had a higher MMP than cells from young animals and were therefore more resistant. Furthermore, this effect was enhanced by curcumin.
Conclusion: Our data suggest that age may affect plasma concentrations, but not the tissue distribution of curcuminoids in mice, but has little impact on mitochondrial function in brain cells.
O presente artigo busca demonstrar que o individuo padece de uma crise de reconhecimento quando busca a solução dos conflitos no poder Judiciário. Este, porém, pode restabelecer apenas o reconhecimento de um dos indivíduos processuais, deixando o outro em processo de não reconhecimento. Desta forma, busca-se comparar os princípios e ideias da jurisdição estatal com os da mediação, demonstrando que a mediação é um processo resolução de conflitos que melhor coaduna suas ideias e princípios com a teoria do reconhecimento. Assim, aplicando a teoria do reconhecimento de Axel Honneth ao modelo jurisdicional convencional, nota-se que uma parte da demanda acaba insatisfeita com a decisão judicial, enquanto, na mediação, busca-se um equilíbrio de satisfações. Devido a esse equilíbrio e convergência, acredita-se que o processo de afirmação da personalidade de nenhuma das partes processuais, quando a mediação é utilizada, seja desarticulado.
La temática de nuestro artículo remite al problema de la dominación en el último libro de Axel Honneth El derecho de la libertad. Para abordar satisfactoriamente este problema consideramos necesario, previamente, reseñar cuáles son las principales afirmaciones del libro y cuál es su enfoque teórico general (1). En el libro de Honneth el tema de la dominación se asocia fuertemente a dos nociones: la de “patologías sociales y de la razón” y la de “anomia”, motivo por el cual centraremos fuertemente la atención en estas cuestiones y llevaremos adelante -y esto vale para todo el artículo- lo que metodológicamente se denomina una reconstrucción conceptual-sistemática (2). Nuestra tesis de lectura es que en el Derecho de la Libertad se echa en falta una concepción “robusta” de dominación que el autor promete en otros libros suyos –tal y como lo advertimos en nuestra investigación doctoral, aún en curso–, pero que finalmente no elabora. Entendemos que esto es una laguna conceptual significativa, sobre todo si se tiene en cuenta que se trata de una reflexión sobre la libertad que pretende inscribirse en el legado de la Teoría Crítica de Frankfurt (3).
Relacionar a temática referente a Teoria do Reconhecimento de Axel Honnet e o direito humano ao trabalho, como direito humano com pretensão de validade universal, sob a perspectiva da Declaração dos Direitos e Princípios Fundamentais no Trabalho da OIT, com fins de fixar parâmetros de reconhecimento e de (re)inserção social da categoria de trabalhadores toxicodependentes é o principal objetivo do presente artigo. Para tanto, analisaremos o marco teórico em que a persecução da dignidade do homem pelo trabalho é o objetivo do Estado para que a seguir possamos tratar da dignidade do homem como direito cuja pretensão de validade é universal, com base da teoria do reconhecimento de Axel Honneth. Isto posto, podemos analisar a possível dignificação do homem pelo trabalho e no trabalho, em um contexto global a partir dos efeitos do reconhecimento de novos direitos, especialmente no que tange à categoria de trabalhadores que ocupam a parcela social de químico-dependentes, cuja participação no processo social está impedida, gerando uma categoria de trabalhadores socialmente excluídos, o que se pretende ultrapassar.
The European Union is at the crossroads between intelligent expansion of future horizons and frightened shrinking to a perspective of local areas. Fear of descent of the citizens on one side and a politics of crisis, that goes along with harsh injustice have made upset the national societies against each other, missing courage on the side of politicians, to bring European issues to the fore, endanger the European project. There is only one way to overcome this situation by establishing a democratic union, which conserves not only the social and civilian achievements of the national state, as well as the assets of a greater democratic political unity, that offers an unity of European citizens and European state demos.
En el presente trabajo abordo la interpretación que Axel Honneth realiza, en su libro Crítica del poder, de la propuesta de Michel Foucault. Honneth señala, a modo de crítica, la existencia de una contradicción entre lo que denomina la teoría del poder de Foucault y sus estudios históricos –en particular, los reunidos en Vigilar y Castigar–. Uno de mis objetivos es explicar esta contradicción y, a partir de ella, proponer una lectura alternativa. En contraposición a Honneth, para quien las instituciones disciplinarias que analiza Foucault terminarían desplazando la acción y la lucha social, intento mostrar –y este es el aporte que busco realizar en el trabajo a partir de una reconstrucción conceptual– que las disciplinas y por añadidura las instituciones disciplinarias deben considerarse tácticas que nunca alcanzan del todo su objetivo. Son tácticas que no logran bloquear, de manera definitiva, las expresiones de resistencia y conflictividad. Esta lectura alternativa que aquí propongo permitiría, en principio, ensayar al menos dos puntos de contacto entre Foucault y la teoría crítica que aún no han sido elucidados.
Em particular em seus textos anteriores a Luta por reconhecimento, Axel Honneth se vale com frequência do adjetivo substantivado "o social" (das Soziale), sem jamais explicitar diretamente o significado que lhe atribui. Todavia, este conceito, sempre pressuposto, tanto está na base de sua conhecida crítica do déficit sociológico da tradição crítica frankfurtiana quanto orienta clandestinamente todo o desenvolvimento de sua obra até o modelo maduro da reconstrução normativa. Trata-se, aqui, de um esforço de torná-lo explícito enquanto compromisso social-ontológico assumido pela teoria crítica honnethiana. Conclui-se que o social de Honneth é senão idêntico, ao menos coextensivo às normas se constituem a partir de interações de reconhecimento intersubjetivo, o que emprestará tanto a força relativa de seu modelo crítico quanto determinará seus limites.
O presente artigo explora os principais conceitos que compõe a teoria do reconhecimento de Axel Honneth, a fim de compreender os propósitos imbricados na idéia de luta por reconhecimento e suas contribuições à nova concepção de identidade surgida a partir da modernidade. No padrão pós-convencional, apresentado por Honneth, o indivíduo é reconhecido em sua individualidade. A identidade subjetiva é constituída de forma intersubjetiva e não mais determinada pelo grupo social. O reconhecimento recíproco é condição para a formação prática da identidade, permitindo ao sujeito participar efetivamente na esfera pública. Contudo, por possuir uma estrutura fundamentalmente intersubjetiva, a identidade individual e coletiva é afetada negativamente pelas diferentes situações de desrespeito presente nos processos de interação social. A negação do reconhecimento de modo injustificado, por meio da violação de expectativas normativas de comportamento, da origem a reações emocionais negativas. Por este motivo, as experiências de desrespeito integram a base motivacional da luta por reconhecimento, dando origem ao conflito social. O tema do conflito em Honneth está vinculado aos processos de formação da identidade prática do sujeito e aos progressos na vida social. O conflito social, traduzido na forma de luta por reconhecimento, caracteriza-se como uma expressão altamente positiva, por contribuir significativamente com a autorrealização individual e coletiva.
Esse artigo tem por objetivo analisar as contribuições de Axel Honneth para o atual debate das teorias da justiça, entre as quais a principal é a busca de princípios normativos encrustados na realidade social. Em sua obra O direito da liberdade, o autor indica a liberdade como o grande valor moderno. O medium da justiça seria uma liberdade de tipo social a qual estaria expressa nas instituições vinculadas às relações pessoais, ao mercado e ao universo político. Considerando a lacuna entre os princípios normativos de justiça indicados pelo autor e a realidade social este artigo propõe colocar em discussão as potencialidades e limites da própria reconstrução normativa como instrumento de análise do social, pautando especificamente o mercado de trabalho, a fim de colaborar à discussão das possibilidades de articular a norma compartilhada e a emergência de valores em vias de institucionalização.
The subject matter of this article is Axel Honneth’s theory of recognition as it has been exposed in his more recent book, Das Recht der Freiheit. Throughout the paper his attempts to describe injustices within modern capitalist societies using the notions of pathologies and anomie will be analyzed and criticized, especially from the viewpoint of their inability to deal with processes and contexts of disrecognition (Aberkennung). With help of this category, Honneth’s diagnosis regarding the moral progress in modern societies, as well as his notion of second order disorders, as injustices will be confronted and, hopefully, complemented.
Este artículo presenta una lectura crítica de un trabajo central de Axel Honneth desde la teoría de la sujeción de Judith Butler. Intenta mostrar que, por la ausencia en su escrito de una consideración sobre el poder, el pensador alemán no logra cumplir satisfactoriamente su objetivo propuesto de enfrentar las posturas que cuestionan el potencial crítico del reconocimiento. La hipótesis que aquí se maneja es que esa ausencia está ligada a su definición del reconocimiento como lo contrario de las prácticas de dominio o sometimiento. Ahora bien, Honneth afirma que el escepticismo de esas posturas respecto del reconocimiento se basa en la idea de que toda praxis recognoscente reproduce de alguna manera el orden social dominante. El presente trabajo se propone entonces, cuestionar esta aseveración del autor advirtiendo que un análisis sobre el modo en que el poder actúa en las prácticas cotidianas de reconocimiento no necesariamente conlleva una renuncia de la función crítica del concepto para la teoría social. Más bien, como sugiere la noción butleriana (y foucaultiana) de crítica, sólo enmarcando al reconocimiento en el horizonte normativo que lo delimita puede convertirse en la base de la indagación social.
Embora a ideia de “patologias sociais” ou “enfermidades” de uma sociedade inteira tenha sido bastante comum desde o Segundo Discurso de Rousseau, e especialmente proeminente dentro da tradição da teoria crítica, não está claro a quem exatamente se referea proposição de ter adoecido. Será apenas um número suficiente de pessoas individuais, será o coletivo entendido como um macro-sujeito, ou é a “sociedade” em si que foi acometida por uma desorganização específica de suas instituições sociais, afetando sua eficiência funcional de tal forma que se pode falar de uma “doença” especificamente social? Para todas as três atribuições, ou seja, as pessoas individualmente com suas doenças, a coletividade com a sua síndrome clínica particular, ou a própria sociedade como adoecida, podem ser encontrados casos na literatura correspondente. A fim de encontrar uma saída para essas perplexidades conceituais que estão no cerne dessa maneira de falar, abordo as propostas teóricas de Alexander Mitscherlich e Sigmund Freud, ambos defensores de um conceito específico de “patologias sociais” ou “enfermidades” baseado em ideias psicanalíticas. O resultado da minha reconstrução crítica será que somente uma compreensão da sociedade como uma entidade orgânica permite um uso não redutor da ideia de “patologias sociais”.
O artigo toma as críticas ao entrelaçamento entre direito e violência como um ponto de partida para explorar a possibilidade de um "tertiumdo direito". Desse modo, busca superar a suposição dicotômica básica que enxerga o direito sempre oscilando entre uma apologia à violência, de um lado, e uma utopia da razão, de outro. O texto analisa a possibilidade dessetertium, uma "força legal" além da violência legal e da razão legal, em quatro passos, recorrendo ao trabalho de Jacques Derrida e de autores da primeira geração da Escola de Frankfurt, em particular, de Theodor Adorno e Walter Benjamin. Argumenta que, em um primeiro passo, o direito precisa ser dissociado do Estado. A violência jurídica, entretanto, não se origina apenas do laço entre direito e poder de Estado. O direito é em si mesmo violento, mesmo quando não é direito de Estado. O segundo passo da crítica legal consiste, portanto, na recordação da violência do direito, seguido por um terceiro, que pede a transformação da violência em força. Essas três instâncias da crítica são as precondições para um passo último e essencial, de acordo com o qual a crítica do direito deve facilitar a transcendência da violência jurídica, tomando o direito e a sua promessa de justiça ao pé da letra com a finalidade de voltar essa promessa contra o próprio direito.
Promove-se uma recuperação do debate endógeno estabelecido entre alguns pensadores da Escola de Frankfurt, sobretudo no que se refere às diferentes perspectivas de análise sobre as relações entre ação e estrutura social, bem como as distintas percepções acerca das racionalidades (prática ou comunicativa) que organizam a conexão entre os indivíduos e a sociedade. Verifica-se o modo como os autores ligados à teoria crítica compreenderam as relações entre esferas subjetivas e estruturais em termos de possibilidades de emancipação social e de exercício de práticas deliberativas. Nessa perspectiva, considera-se uma cisão teórica estabelecida no interior da própria escola, cuja expressão se dá a partir das diferenças epistemológicas existentes entre o núcleo central do pensamento frankfurtiano e um conjunto de autores periféricos. Os trabalhos produzidos por esse núcleo “marginal”, bem como seu posterior refinamento na obra de Habermas, apresentam alternativas teóricas de caráter relacional que contrapõem a visão estrutural e cética presente nos trabalhos de Horkheimer, Adorno e Marcuse. É justamente na recuperação dessas fronteiras endógenas que se pretende ponderar as possíveis contribuições do pensamento frankfurtiano para uma perspectiva crítica da sociedade contemporânea.
Die Südostasienwissenschaften der Goethe-Universität Frankfurt a. M. luden in Zusammenarbeit mit der Südostasien Informationsstelle im Asienhaus Köln und dem Arbeitskreis Südostasien der Deutschen Gesellschaft für Asienkunde den 19. und 20. Juni 2015 zu der Konferenz „Die Schattenseiten des Wirtschaftswachstums in Südostasien“ nach Frankfurt ein...
Rationale: Early reperfusion in patients experiencing acute ischemic stroke is critical, especially for patients with large vessel occlusion who have poor prognosis without revascularization. S olitaire™ stent retriever devices have been shown to immediately restore vascular perfusion safely, rapidly, and effectively in acute ischemic stroke patients with large vessel occlusions.
Aim: The aim of the study was to demonstrate that, among patients with large vessel, anterior circulation occlusion who have received intravenous tissue plasminogen activator, treatment with S olitaire revascularization devices reduces degree of disability 3 months post stroke.
Design: The study is a global multicenter, two‐arm, prospective, randomized, open, blinded end‐point trial comparing functional outcomes in acute ischemic stroke patients who are treated with either intravenous tissue plasminogen activator alone or intravenous tissue plasminogen activator in combination with the Solitaire device. Up to 833 patients will be enrolled.
Procedures:Patients who have received intravenous tissue plasminogen activator are randomized to either continue with intravenous tissue plasminogen activator alone or additionally proceed to neurothrombectomy using the S olitaire device within six‐hours of symptom onset.
Study Outcomes: The primary end‐point is 90‐day global disability, assessed with the modified R ankin S cale (mRS). Secondary outcomes include mortality at 90 days, functional independence (mRS ≤ 2) at 90 days, change in N ational I nstitutes of H ealth S troke S cale at 27 h, reperfusion at 27 h, and thrombolysis in cerebral infarction 2b/3 flow at the end of the procedure.
Analysis:Statistical analysis will be conducted using simultaneous success criteria on the overall distribution of modified R ankin S cale (R ankin shift) and proportions of subjects achieving functional independence (mRS 0–2).
Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.
Tracheomalacia or tracheobronchomalacia (TM or TBM) is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a patient with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to Parkinson’s disease. The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the patient. In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50–60€ inclusive of taxes. In our own hospital (tertiary level), it is nearly 30€ per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for patient preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6€. Although the Dumon stenting requires a set-up with more expensive anesthesiology accompaniment, which takes longer than a flexible investigation estimated at 1 hour in an operation room, still without calculation of the costs of the materials and specialized staff that the surgical approach would consume at least 3,000€ more than a minimally invasive approach performed with the Berci needle. This difference is due to the longer time of the surgical intervention which is calculated at approximately 180 minutes in comparison to the achieved non-surgical approach of 60 minutes in the operation suite.
Understanding land cover degradation patterns and the effects of geomorphological units on phytodiversity is important for guiding management decisions and restoration strategies in the Sahelian vulnerables zones. This paper describes land cover degradation by combining Landsat TM image analysis and field data measurements in the Gourouol catchment of the Sahelian zone of Burkina Faso. Erdas Imagine 9.2 and Arc-GIS.10 were applied. The change patterns were obtained by superposing land cover maps for 1992 and 2010. The field data were collected by the mean of inventories according to the Braun-Blanquet phytosociological relevés methods. Plot sizes were 50 m x 20 m for woody species and 10 m x 10 m for herbaceous species. Six land cover types were identified and mapped: cultivated lands, bared lands, lowlands, which all spatially increased; and shrub-steppes, grasslands and water bodies, which all spatially decreased. The dynamic patterns based on the geomorphological units were non-degraded lowlands, stable sand dunes and degraded glacis. High plant diversity was found in lowlands, whereas low diversity occurred in glacis. A significant dissimilarity was observed between communities. The Shannon diversity indices in plant communities were approximately close to ln(species richness). The Pielou indices were close to 1, indicating a species fairly good distribution. Our results showed a variation of land cover over time and the effects of geomorphological units on phytodiversity. Furthermore, this variation helps oppose land degradation in the Sahel.
In a political and economic perspective, the recent ECJ judgment on the OMT program is not more than a footnote, a short sideshow in a seemingly never-ending sequel of another dimension. Legally, however, I find the case quite remarkable. Unlike its Advocate General, the ECJ did not yield to the temptation to respond in kind to the FCC’s provocations. In particular, it avoids the issue of domestic vs. European constitutional identity that juxtaposed the FCC and the Advocate General. Instead, the ECJ has shown political responsibility and legal foresight in framing what could become a masterpiece of truly cooperative, other-regarding constitutional pluralism.
Bundesfinanzminister Wolfgang Schäubles Behauptung, Griechenland könne wegen Art. 125 AEUV nur außerhalb der Eurozone seine Schulden gegenüber anderen Euro-Staaten und EFSF bzw. ESM restrukturieren, beruht auf einem Denkfehler, wenn nicht gar auf einem Taschenspielertrick. Die Pringle-Rechtsprechung des EuGH zeigt: Das Europarecht schaufelt sich nicht sein eigenes Grab. Man muss es nicht erst umgehen, um die Ziele der Union wahrhaft zu verwirklichen.
The present research investigates if and how a more digitally centered communication between supervisors and employees satisfies employees’ needs regarding the communication with their supervisors and influences employees’ attitudes toward the supervisor and the job. In a cross-sectional online study, 261 employees rated their supervisors’ actual and ideal use of different communication channels (i.e., telephone, face-to-face, email) regarding quality and quantity. Employees’ job satisfaction and their perceptions of their supervisors’ effectiveness and team identification were measured as dependent variables. Employees perceived face-to-face communication to be of higher quality than telephone and email communication, and they indicated a preference for more face-to-face communication with their supervisors than they actually had. Moreover, the perceived quality of communication, especially via face-to-face, was strongly and positively related to the dependent variables. These results provide insights into potential problems of increasing e-leadership in organizations. We conclude with recommendations to reduce these problems.
Herausforderungen für die nationale, regionale und thematische Webarchivierung und deren Nutzung
(2015)
Das World Wide Web ist als weltweites Informations- und Kommunikationsmedium etabliert. Neue Technologien erweitern regelmäßig die Nutzungsformen und erlauben es auch unerfahrenen Nutzern, Inhalte zu publizieren oder an Diskussionen teilzunehmen. Daher wird das Web auch als eine gute Dokumentation der heutigen Gesellschaft angesehen. Aufgrund seiner Dynamik sind die Inhalte des Web vergänglich und neue Technologien und Nutzungsformen stellen regelmäßig neue Herausforderungen an die Sammlung von Webinhalten für die Webarchivierung. Dominierten in den Anfangstagen der Webarchivierung noch statische Seiten, so hat man es heute häufig mit dynamisch generierten Inhalten zu tun, die Informationen aus verschiedenen Quellen integrieren. Neben dem klassischen domainorientieren Webharvesting kann auch ein steigendes Interesse aus verschiedenen Forschungsdisziplinen an thematischen Webkollektionen und deren Nutzung und Exploration beobachtet werden. In diesem Artikel werden einige Herausforderungen und Lösungsansätze für die Sammlung von thematischen und dynamischen Inhalten aus dem Web und den sozialen Medien vorgestellt. Des Weiteren werden aktuelle Probleme der wissenschaftlichen Nutzung diskutiert und gezeigt, wie Webarchive und andere temporale Kollektionen besser durchsucht werden können.
Non-VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of anticoagulation. While the marketing authorization holders claimed that no routine monitoring is required and that these compounds can be given at fixed doses, several evidences arisen from the literature tend to demonstrate the opposite. New data suggests that an assessment of the response at the individual level could improve the benefit-risk ratio of at least dabigatran. Information regarding the association of rivaroxaban and apixaban exposure and the bleeding risk is available in the drug approval package on the FDA website. These reviews suggest that accumulation of these compounds increases the risk of experiencing a bleeding complication. Therefore, in certain patient populations such as patients with acute or chronic renal impairment or with multiple drug interactions, measurement of drug exposure may be useful to ensure an optimal treatment response. More specific circumstances such as patients experiencing a haemorrhagic or thromboembolic event during the treatment duration, patients who require urgent surgery or an invasive procedure, or patient with a suspected overdose could benefit from such a measurement. This paper aims at providing guidance on how to best estimate the intensity of anticoagulation using laboratory assays in daily practice.
CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhibitors of CXCR4-tropic HIV-1 strains. This approach identified a 16 amino acid fragment of serum albumin as an effective and highly specific CXCR4 antagonist. The endogenous peptide, termed EPI-X4, is evolutionarily conserved and generated from the highly abundant albumin precursor by pH-regulated proteases. EPI-X4 forms an unusual lasso-like structure and antagonizes CXCL12-induced tumor cell migration, mobilizes stem cells, and suppresses inflammatory responses in mice. Furthermore, the peptide is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker. Our results identify EPI-X4 as a key regulator of CXCR4 signaling and introduce proteolysis of an abundant precursor protein as an alternative concept for chemokine receptor regulation.
The title compound, C21H26Cl2N2O2, was prepared in a solvent-free microwave-assisted synthesis, and crystallizes in the orthorhombic space group Pna21. The imidazolidine ring adopts an envelope conformation and its mean plane is almost perpendicular to the two pendant aromatic rings [dihedral angles = 84.61 (9) and 86.54 (9)°]. The molecular structure shows the presence of two intramolecular O—H⋯N hydrogen bonds between the phenolic hydroxy groups and imidazolidine N atoms. The two 3-chloro-6-hydroxy-2,4-dimethylbenzyl groups are located in a cis orientation with respect to the imidazolidine fragment. As a result, the lone pairs of electrons on the N atoms are presumed to be disposed in a syn conformation. This is therefore the first example of an exception to the `rabbit-ears' effect in such 2,2′-[imidazolidine-1,3-diylbis(methylene)]diphenol derivatives.
Background: In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in combination with ionizing radiation on apoptosis, cell cycle regulation, DNA double-strand break (DSB) repair, three-dimensional (3D) clonogenic survival and expression of IAPs in colorectal carcinoma cells.
Material and methods: Colorectal cancer cell lines (HCT-15, HT-29, SW480) were subjected to BV6 treatment (0–4 μM) with or without irradiation (2–8 Gy, single dose) followed by MTT, Caspase 3/7 activity, γH2AX/53BP1 foci assays, AnnexinV staining, cell cycle analysis, 3D colony forming assays and Western blotting (cellular IAP1 (cIAP1) and cIAP2, Survivin, X-linked IAP (XIAP)).
Results: BV6 treatment decreased cell viability and significantly increased irradiation-induced apoptosis as analyzed by Caspase 3/7 activity, AnnexinV-positive and subG1 phase cells. While basal 3D clonogenic survival was decreased in a cell line-dependent manner, BV6 significantly enhanced cellular radiosensitivity of all cell lines in a concentration-dependent manner and increased the number of radiation-induced γH2AX/53BP1-positive foci. Western blot analysis revealed a markedly reduced cIAP1 expression at 4 h after BV6 treatment in all cell lines, a substantial reduction of XIAP expression in SW480 and HT-29 cells at 24 h and a slightly decreased cIAP2 expression in HCT-15 cells at 48 h after treatment. Moreover, single or double knockdown of cIAP1 and XIAP resulted in significantly increased residual γH2AX/53BP1-positive foci 24 h after 2 Gy and radiosensitization relative to control small interfering RNA (siRNA)-treated cells.
Conclusion: The SMAC mimetic BV6 induced apoptosis and hampered DNA damage repair to radiosensitize 3D grown colorectal cancer cells. Our results demonstrate IAP targeting as a promising strategy to counteract radiation resistance of colorectal cancer cells.
Repeated Quaternary glaciations have significantly shaped the present distribution and diversity of several European species in aquatic and terrestrial habitats. To study the phylogeography of freshwater invertebrates, patterns of intraspecific variation have been examined primarily using mitochondrial DNA markers that may yield results unrepresentative of the true species history. Here, population genetic parameters were inferred for a montane aquatic caddisfly, T hremma gallicum , by sequencing a 658‐bp fragment of the mitochondrial CO 1 gene, and 12,514 nuclear RAD loci. T . gallicum has a highly disjunct distribution in southern and central Europe, with known populations in the Cantabrian Mountains, Pyrenees, Massif Central, and Black Forest. Both datasets represented rangewide sampling of T. gallicum . For the CO 1 dataset, this included 352 specimens from 26 populations, and for the RAD dataset, 17 specimens from eight populations. We tested 20 competing phylogeographic scenarios using approximate Bayesian computation (ABC ) and estimated genetic diversity patterns. Support for phylogeographic scenarios and diversity estimates differed between datasets with the RAD data favouring a southern origin of extant populations and indicating the Cantabrian Mountains and Massif Central populations to represent highly diverse populations as compared with the Pyrenees and Black Forest populations. The CO 1 data supported a vicariance scenario (north–south) and yielded inconsistent diversity estimates. Permutation tests suggest that a few hundred polymorphic RAD SNP s are necessary for reliable parameter estimates. Our results highlight the potential of RAD and ABC‐based hypothesis testing to complement phylogeographic studies on non‐model species.
Data supporting the role of the non-glycosylated isoform of MIC26 in determining cristae morphology
(2015)
Membrane architecture is crucially important for mitochondrial function and integrity. The MICOS complex is located at crista junctions and determines cristae membrane morphology and the formation of crista junctions. Here we provide data of the bona fide MICOS subunit MIC26 for determining cristae morphology. MiRNA-mediated downregulation of MIC26 results in higher protein levels of MIC27 and in lower levels of Mic10. Using a miRNA-resistant form to MIC26 we show that this effect is specific to MIC26. Our data further demonstrate that depletion of MIC26 primarily affects the level of the 22 kDa mitochondrial isoform of MIC26 but not the amount of the secreted 55 kDa isoform of MIC26. Depletion of MIC27, however, increases secretion of the latter isoform. Overexpression of a myc-tagged version of MIC26 resulted in altered cristae morphology with swollen and partly vesicular cristae-structures.
Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant SZ risk variants to test the predictive capacity of the polygenic model and explored potential associations with white matter volume, a key candidate in imaging phenotype for psychotic disorders.
By calculating the combined additive schizophrenia risk of seven SNPs (significant hits from a recent schizophrenia GWAS study), we show that increased additive genetic risk for SZ was associated with reduced white matter volume in a group of participants (n = 94) consisting of healthy individuals, SZ first-degree relatives, SZ patients and BD patients. This effect was also seen in a second independent sample of healthy individuals (n = 89). We suggest that a moderate portion of variance (~4%) of white matter volume can be explained by the seven hits from the recent schizophrenia GWAS.
These results provide evidence for associations between cumulative genetic risk for schizophrenia and intermediate neuroimaging phenotypes in models of psychosis. Our work contributes to a growing body of literature suggesting that polygenic risk may help to explain white matter alterations associated with familial risk for psychosis.