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Invasive coronary angiography (ICA) was the only method to image coronary arteries for a long time and is still the gold-standard. Technology of noninvasive imaging by coronary computed-tomography angiography (CCTA) has experienced remarkable progress during the last two decades. It is possible to visualize atherosclerotic lesions in the vessel wall in contrast to "lumenography" performed by ICA. Coronary artery disease can be ruled out by CCTA with excellent accuracy. The degree of stenoses is, however, often overestimated which impairs specificity. Atherosclerotic lesions can be characterized as calcified, non-calcified and partially calcified. Calcified plaques are usually quantified using the Agatston-Score. Higher scores are correlated with worse cardiovascular outcome and increased risk of cardiac events. For non-calcified or partially calcified plaques different angiographic findings like positive remodelling, a large necrotic core or spotty calcification more frequently lead to myocardial infarctions. CCTA is an important tool with increasing clinical value for ruling out coronary artery disease or relevant stenoses as well as for advanced risk stratification.
The Asian bush mosquito (Aedes japonicus japonicus, Theobald 1901) is an invasive culicid species which originates in Asia but is nowadays present in northern America and Europe. It is a competent vector for several human disease pathogens. In addition to the public health threat, this invasive species may also be an ecological threat for native container-breeding mosquitoes which share a similar larval habitat. Therefore, it is of importance to gain knowledge on ecological and eco-toxicological features of the Asian bush mosquito. However, optimal laboratory feeding conditions have not yet been established. Standardized feeding methods will be needed in assessing the impact of insecticides or competitional strength of this species. To fill this gap, we performed experiments on food quality and quantity for Ae. j. japonicus larvae. We found out that the commercial fish food TetraMin (Tetra, Melle, Germany) in a dose of 10 mg per larva is the most suitable food tested. We also suggest a protocol with a feeding sequence of seven portions for all larval stages of this species.
2004 erschütterten Terroranschläge in London und Madrid die Welt. Die Reaktion der EU/EG im seinerzeit schnellsten Gesetzgebungsverfahren seit Bestehen: Verabschiedung der Vorratsdatenspeicherungsrichtlinie. 2009 sah der EuGH die Richtlinie trotzdem als Binnenmarktregelung an, mit der Harmonisierung auf dem Informationsmarkt herbeigeführt werden sollte. Äußerungen zum Inhalt – quasi als obiter dictum möglich gewesen – versagte er sich. 2010 beurteilte dann das BVerfG die bundesdeutsche Umsetzung, aber – ganz dem Verhältnis von EuGH und BVerfG entsprechend – nur den die europäischen Mindestvorgaben überschießenden Teil. Dieses Gesetz hatte national schon für reichlich Sprengstoff im Rechtsstaat gesorgt und u.a. den Rücktritt der beharrlich widersetzlichen Justizministerin bewirkt. ...
An den Europäischen Außengrenzen gehört der Tod von Flüchtlingen zum Alltag. Mehr als 29.000 Menschen sollen seit dem Jahr 2000 nach Recherchen von Journalist*innen auf ihrem Weg nach Europa gestorben sein. Das Projekt The Human Costs of Border Control der Universität Amsterdam hat jüngst eine Datenbank öffentlich gemacht, in der die tödlichen Umstände von über 3.000 Flüchtlingen dokumentiert werden. ...
Die Mordserie des Nationalsozialistischen Untergrunds (NSU) hat eine beispiellose Reihe von Skandalen deutscher Sicherheitsbehörden öffentlich gemacht. In der vergangenen Woche hat ein Artikel in der Welt am Sonntag von den Journalisten Stefan Aust, Dirk Laabs und Per Hinrichs ein neues Kapitel in die Geschichte des NSU-Komplex eingefügt. ...
Viel zu selten erhält der Münchner NSU-Prozess die Öffentlichkeit, die seinem Gegenstand entsprechen würde. Der 249. Verhandlungstag wird jedoch in Erinnerung bleiben. Die Hauptangeklagte Beate Zschäpe hat ihr Schweigen gebrochen und zum ersten Mal über ihren neuen Anwalt Mathias Grasel eine Aussage verlesen lassen (vgl. Vollständiges Protokoll). Diese lässt sich mit dem Egotronic-Song "Von nichts gewusst" zusammenfassen. Dass die beiden Uwes Morde begangen haben? Nichts gewusst, erst später habe sie davon erfahren. Der Bombenanschlag in der Kölner Keupstraße? Nichts gewusst. Der Inhalt des NSU-Bekennervideos, das sie selbst per Post verschickt hat? Habe sie im Prozess zum ersten Mal gesehen. ...
The richest compilation to date of essays in the political theory of European integration has just landed with a thud, and is bound to reverberate for some time in the sleek corridors of Brussels and the wood-paneled seminar rooms of Bruges. Edited by Kochenov, de Búrca, and Williams, Europe’s Justice Deficit? is more than an attempt to initiate a discussion about the questions of justice prompted by European integration. With thirty contributions by leading scholars of law, history, political science and philosophy, not much worth noting on this seemingly boundless subject is left unsaid. ...
The concept of culturomics was born out of the availability of massive amounts of textual data and the interest to make sense of cultural and language phenomena over time. Thus far however, culturomics has only made use of, and shown the great potential of, statistical methods. In this paper, we present a vision for a knowledge-based culturomics that complements traditional culturomics. We discuss the possibilities and challenges of combining knowledge-based methods with statistical methods and address major challenges that arise due to the nature of the data; diversity of sources, changes in language over time as well as temporal dynamics of information in general. We address all layers needed for knowledge-based culturomics, from natural language processing and relations to summaries and opinions.
Secondary plant metabolites reveal numerous biological activities making them attractive as resource for drug development of human diseases. As the majority of cancer drugs clinically established during the past half century is derived from nature, cancer researchers worldwide try to identify novel natural products as lead compounds for cancer therapy. Natural products are considered as promising cancer therapeutics, either as single agents or in combination protocols, to enhance the antitumor activity of additional therapeutic modalities. Most natural compounds exert pleotrophic effects and modulate various signal transduction pathways. A better understanding of the complex mechanisms of action of natural products is expected to open new perspectives in coming years for their use alone or in combination therapies in oncology. Two major strategies to identify novel drug candidates from nature are the bioactivity-guided fractionation of medicinal plant extracts to isolate cytotoxic chemicals and the identification of small molecules inhibiting specific targets in cancer cells. In the present review, we report on our own efforts to unravel the molecular modes of action of phytochemicals in cancer cells and focus on resveratrol, betulinic acid, artesunate, dicentrine and camptothecin derivatives.
The title of this study is applying team teaching to improve student ability in understanding English narrative texts. The purposes of this study are to identify the advantages and to find out the strategies of applying team teaching to improve students ability in understanding English narrative texts. The population of this study is the first year students of SMAN 4 Banda Aceh, and the sample are an experimental class (X IA 2) and a control class (X IA 6). The total numbers of the samples are 66 students. This research was conducted on April, 2010. In collecting data, several techniques were used namely; observation, test, questionnaire and interview. According to data analysis, team teaching gave more advantages to improve students’ ability in understanding English narrative texts. Some advantages of team teaching to the first year students of SMAN 4 Banda Aceh; (1) Team teaching directed the students to focus on material, the method was not tedious and learning motivation had been increased by using it, so that their ability in understanding English narrative text had been increased. (2) The students who studied by using team teaching obtained higher score than the students who studied without using team teaching. It means the students who studied by using team teaching could improve their abilities in understanding English narrative text. (3) The students should focus on the study because the teachers observed what they do in the class comprehensively. The student also could receive knowledge not only from the main teacher, but also from the co-teacher and they could ask both teachers if they found some problems. Some advantages of team teaching to the teachers of SMAN 4 Banda Aceh are; team teaching could be effective while teaching and learning process was underway because the teachers could remind each other and they also could plan good materials. In applying team teaching to improve students’ ability in understanding English narrative texts, the teachers used many strategies. One of the general strategies to apply team teaching in SMAN 4 Banda Aceh was by excercising the so called semi team teaching. The special strategies that conducted by teachers were; (1) Presenting an interesting and understandable topic in every meeting for students. (2) Making group discussion, reading the legend and translating it, giving regularly the test and games. (3) Asking the students to comprehend the generic structure of the text before coming to the class.
Exclusive measurements of quasi-free proton scattering reactions in inverse and complete kinematics
(2015)
Quasi-free scattering reactions of the type (p, 2p) were measured for the first time exclusively in complete and inverse kinematics, using a 12C beam at an energy of ∼400 MeV/u as a benchmark. This new technique has been developed to study the single-particle structure of exotic nuclei in experiments with radioactive-ion beams. The outgoing pair of protons and the fragments were measured simultaneously, enabling an unambiguous identification of the reaction channels and a redundant measurement of the kinematic observables. Both valence and deeply-bound nucleon orbits are probed, including those leading to unbound states of the daughter nucleus. Exclusive (p, 2p) cross sections of 15.8(18) mb, 1.9(2) mb and 1.5(2) mb to the low-lying 0p-hole states overlapping with the ground state (3/2−) and with the bound excited states of 11B at 2.125 MeV (1/2−) and 5.02 MeV (3/2−), respectively, were determined via γ -ray spectroscopy. Particle-unstable deep-hole states, corresponding to proton removal from the 0s-orbital, were studied via the invariant-mass technique. Cross sections and momentum distributions were extracted and compared to theoretical calculations employing the eikonal formalism. The obtained results are in a good agreement with this theory and with direct-kinematics experiments. The dependence of the proton–proton scattering kinematics on the internal momentum of the struck proton and on its separation energy was investigated for the first time in inverse kinematics employing a large-acceptance measurement.
We present an extensive experimental study of the recently predicted pygmy quadrupole resonance (PQR) in Sn isotopes, where complementary probes were used. In this study, (α,α' γ ) and (γ , γ') experiments were performed on 124Sn. In both reactions, Jπ = 2+ states below an excitation energy of 5 MeV were populated. The E2 strength integrated over the full transition densities could be extracted from the (γ , γ') experiment, while the (α,α'γ ) experiment at the chosen kinematics strongly favors the excitation of surface modes because of the strong α-particle absorption in the nuclear interior. The excitation of such modes is in accordance with the quadrupole-type oscillation of the neutron skin predicted by a microscopic approach based on self-consistent density functional theory and the quasiparticle-phonon model (QPM). The newly determined γ -decay branching ratios hint at a non-statistical character of the E2 strength, as it has also been recently pointed out for the case of the pygmy dipole resonance (PDR). This allows us to distinguish between PQR-type and multiphonon excitations and, consequently, supports the recent first experimental indications of a PQR in 124Sn.
Partial cross sections of the 89Y(p, γ )90Zr reaction have been measured to investigate the γ-ray strength function in the neutron–magic nucleus 90Zr. For five proton energies between E p = 3.65 MeV and E p = 4.70 MeV partial cross sections for the population of seven discrete states in 90Zr have been determined by means of in-beam γ-ray spectroscopy. Since these γ-ray transitions are dominantly of E1 character, the present measurement allows an access to the low-lying dipole strength in 90Zr. A γ-ray strength function based on the experimental data could be extracted, which is used to describe the total and partial cross sections of this reaction by Hauser–Feshbach calculations successfully. Significant differences with respect to previously measured strength functions from photoabsorption data point towards deviations from the Brink–Axel hypothesis relating the photo-excitation and de-excitation strength functions.
The technique of self absorption has been applied for the first time to study the decay pattern of low-lying dipole states of 140Ce. In particular, ground-state transition widths 0 and branching ratios 0/ to the ground state have been investigated in the energy domain of the pygmy dipole resonance. Relative self-absorption measurements allow for a model-independent determination of 0. Without the need to perform a full spectroscopy of all decay channels, also the branching ratio to the ground state can be determined. The experiment on 140Ce was conducted at the bremsstrahlung facility of the superconducting Darmstadt electron linear accelerator S-DALINAC. In total, the self-absorption and, thus, 0 were determined for 104 excited states of 140Ce. The obtained results are presented and discussed with respect to simulations of γ cascades using the DICEBOX code.
Formation of hypermatter and hypernuclei within transport models in relativistic ion collisions
(2015)
Within a combined approach we investigate the main features of the production of hyper-fragments in relativistic heavy-ion collisions. The formation of hyperons is modeled within the UrQMD and HSD transport codes. To describe the hyperon capture by nucleons and nuclear residues a coalescence of baryons (CB) model was developed. We demonstrate that the origin of hypernuclei of various masses can be explained by typical baryon interactions, and that it is similar to processes leading to the production of conventional nuclei. At high beam energies we predict a saturation of the yields of all hyper-fragments, therefore, this kind of reactions can be studied with high yields even at the accelerators of moderate relativistic energies.
Currently, the structure of the X(3872) meson is unknown. Different competing models of the exotic state X(3872) exist, including the possibilities that this state is either a mesonic molecule with dominating D0D¯ ∗0 + c.c. composition, a tetraquark, or a -gluon hybrid state. It is expected that the X(3872) state is rather strongly coupled to the channel and, therefore, can be produced in and collisions at PANDA. We propose to test the hypothetical molecular structure of by studying the D or D¯⁎ stripping reactions on a nuclear residue.
Thermal dilepton radiation from the hot fireballs created in high-energy heavy-ion collisions provides unique insights into the properties of the produced medium. We first show how the predictions of hadronic many-body theory for a melting ρ meson, coupled with quark–gluon plasma emission utilizing a modern lattice-QCD based equation of state, yield a quantitative description of dilepton spectra in heavy-ion collisions at the SPS and the RHIC beam energy scan program. We utilize these results to systematically extract the excess yields and their invariant-mass spectral slopes to predict the excitation function of fireball lifetimes and (early) temperatures, respectively. We thereby demonstrate that future measurements of these quantities can yield unprecedented information on basic fireball properties. Specifically, our predictions quantify the relation between the measured and maximal fireball temperature, and the proportionality of excess yield and total lifetime. This information can serve as a “caloric” curve to search for a first-order QCD phase transition, and to detect non-monotonous lifetime variations possibly related to critical phenomena.
In the initial stage of relativistic heavy-ion collisions, strong magnetic fields appear due to the large velocity of the colliding charges. The evolution of these fields appears as a novel and intriguing feature in the fluid-dynamical description of heavy-ion collisions. In this work, we study analytically the one-dimensional, longitudinally boost-invariant motion of an ideal fluid in the presence of a transverse magnetic field. Interestingly, we find that, in the limit of ideal magnetohydrodynamics, i.e., for infinite conductivity, and irrespective of the strength of the initial magnetization, the decay of the fluid energy density e with proper time τ is the same as for the time-honoured “Bjorken flow” without magnetic field. Furthermore, when the magnetic field is assumed to decay , where a is an arbitrary number, two classes of analytic solutions can be found depending on whether a is larger or smaller than one. In summary, the analytic solutions presented here highlight that the Bjorken flow is far more general than formerly thought. These solutions can serve both to gain insight on the dynamics of heavy-ion collisions in the presence of strong magnetic fields and as testbeds for numerical codes.
We compute the probability distribution P(N) of the net-baryon number at finite temperature and quark-chemical potential, μ, at a physical value of the pion mass in the quark-meson model within the functional renormalization group scheme. For μ/T < 1, the model exhibits the chiral crossover transition which belongs to the universality class of the O(4) spin system in three dimensions. We explore the influence of the chiral crossover transition on the properties of the net baryon number probability distribution, P(N). By considering ratios of P(N) to the Skellam function, with the same mean and variance, we unravel the characteristic features of the distribution that are related to O(4) criticality at the chiral crossover transition. We explore the corresponding ratios for data obtained at RHIC by the STAR Collaboration and discuss their implications. We also examine O(4) criticality in the context of binomial and negative-binomial distributions for the net proton number.