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The richest compilation to date of essays in the political theory of European integration has just landed with a thud, and is bound to reverberate for some time in the sleek corridors of Brussels and the wood-paneled seminar rooms of Bruges. Edited by Kochenov, de Búrca, and Williams, Europe’s Justice Deficit? is more than an attempt to initiate a discussion about the questions of justice prompted by European integration. With thirty contributions by leading scholars of law, history, political science and philosophy, not much worth noting on this seemingly boundless subject is left unsaid. ...
Römische Grabbauten sind im Grunde kein Thema, dem es an wissenschaftlicher Aufmerksamkeit mangelt. Allerdings lag der Fokus in den vergangenen Jahrzehnten beinahe durchweg auf den Denkmälern in Rom und Italien, die sowohl aus bautypologischer als auch aus sozial- und kulturhistorischer Perspektive intensiv erforscht wurden und werden. Für die Grabbauten in den Provinzen, insbesondere den Nordwestprovinzen fehlte es dagegen lange an übergreifenden Studien. Diese Lücke wird nun durch die in Teilen auf den Ergebnissen eines EUProjektes zum Thema "Transformation" aufbauende Studie von Markus Scholz (S.) geschlossen, der sich den erhaltenen Denkmälern in detaillierter Weise anhand einer typologischen Methodik annimmt. Der Größe des Untersuchungsgebiets, das von Britannien über die Rhein- und Donauprovinzen bis ans Schwarze Meer reicht, und der damit einhergehend immensen Zahl einbezogener Objekte (ca. 3500 Grabbauten) entspricht auch der Umfang des Werkes, das mit zwei Bänden mit jeweils rund 570 Seiten bereits auf den ersten Blick gewichtig anmutet. ...
For the environs of the Late Bronze Age fortification enclosure Iarcuri the hydro-morphological relief characteristics are combined with archaeological evidences. Target of the study is to evaluate the impact of settlement activities in the surroundings of Iarcuri on the development of the channel network. Data analysis is based on topographic map-derived and high resolution DEMs provided by LiDAR scanning; derivatives of the DEMs are used to characterize the different sub-catchments that show varying influences by the fortification ramparts. The tributaries reaching the receiving stream close to the central settlement area source close to the gates in the ramparts in the Late Bronze Age built-up areas. Additionally, also the geometry of these tributaries differs from that of other tributaries. The distinct character of the channel network with repeatedly occurring rectangular bends indicates the capture of channels, which developed as gullies along paths by retrogressive erosion.
The assumed space : pre-reflective spatiality and doctrinal configurations in juridical experience
(2015)
The purpose of this contribution is to analyse, by means of the legal-historical perspective, the relationship between the pre-reflections of space and the configurations of legal concepts and categories. Three examples of the interplay between doctrinal configurations and the spatial dimension within the context of three different historical periods will be illustrated: given space in the Middle Ages, possible space in the Modern Age and decided space in the Contemporary Age. From this basis, the essay considers the heuristic importance of such an analytical approach – mindful of the profiles of presupposition, such as the space assumption, underlying the conceptualisation of ideas – for a history attentive to the constraints of the theoretical sustainability of legal concepts.
A current challenge in life sciences is to image cell membrane receptors while characterizing their specific interactions with various ligands. Addressing this issue has been hampered by the lack of suitable nanoscopic methods. Here we address this challenge and introduce multifunctional high-resolution atomic force microscopy (AFM) to image human protease-activated receptors (PAR1) in the functionally important lipid membrane and to simultaneously localize and quantify their binding to two different ligands. Therefore, we introduce the surface chemistry to bifunctionalize AFM tips with the native receptor-activating peptide and a tris-N-nitrilotriacetic acid (tris-NTA) group binding to a His10-tag engineered to PAR1. We further introduce ways to discern between the binding of both ligands to different receptor sites while imaging native PAR1s. Surface chemistry and nanoscopic method are applicable to a range of biological systems in vitro and in vivo and to concurrently detect and localize multiple ligand-binding sites at single receptor resolution.
Proton-pumping complex I of the mitochondrial respiratory chain is among the largest and most complex membrane protein complexes. The enzyme contributes substantially to oxidative energy-conversion in eukaryotic cells. Its malfunctions are implicated in many hereditary and degenerative disorders. Here, we report the X-ray structure of mitochondrial complex I at 3.6- 3.9 Å resolution describing in detail the central subunits that execute the bioenergetic function. A continuous axis of basic and acidic residues running centrally through the membrane arm connects the ubiquinone reduction site in the hydrophilic arm to four putative proton-pumping units. The binding position for a substrate analogous inhibitor and blockage of the predicted ubiquinone binding site provide a model for the ‘deactive’ form of the enzyme. The proposed transition into the active form is based on a concerted structural rearrangement at the ubiquinone reduction site rendering support for a two-state stabilization-change mechanism of protonpumping.