Medizin
Refine
Year of publication
Has Fulltext
- yes (556)
Is part of the Bibliography
- no (556)
Keywords
- inflammation (29)
- macrophage (13)
- glioblastoma (10)
- cancer (9)
- prostate cancer (9)
- SARS-CoV-2 (8)
- hypoxia (8)
- apoptosis (7)
- data science (7)
- macrophages (7)
- pain (7)
- epilepsy (6)
- macrophage polarization (6)
- miRNA (6)
- microRNA (6)
- COVID-19 (5)
- Cirrhosis (5)
- autophagy (5)
- breast cancer (5)
- curcumin (5)
- differentiation (5)
- environmental tobacco smoke (5)
- lipocalin-2 (5)
- multiple sclerosis (5)
- neurodegeneration (5)
- particulate matter (5)
- prevalence (5)
- proliferation (5)
- stroke (5)
- Aspergillus (4)
- B cells (4)
- Gene expression (4)
- Hemorrhage (4)
- Labor and delivery (4)
- Liver diseases (4)
- MSD (4)
- Magnetic resonance imaging (4)
- Musculoskeletal system (4)
- NKG2D (4)
- Pregnancy (4)
- ataxia telangiectasia (4)
- biomarker (4)
- bipolar disorder (4)
- bladder cancer (4)
- child (4)
- children (4)
- endothelial cells (4)
- epidemiology (4)
- immunotherapy (4)
- infection (4)
- integrins (4)
- iron (4)
- mTOR (4)
- machine learning (4)
- mesenchymal stromal/stem cells (4)
- migration (4)
- obesity (4)
- outcome (4)
- polytrauma (4)
- psoriasis (4)
- radical prostatectomy (4)
- sphingosine-1-phosphate (4)
- sulforaphane (4)
- thymus (4)
- tumor microenvironment (4)
- Acute myeloid leukemia (3)
- Cancer treatment (3)
- DNA methylation (3)
- Death rates (3)
- EEG microstates (3)
- Evaluation (3)
- Gender (3)
- General practice (3)
- Hepatocellular carcinoma (3)
- Inflammation (3)
- Kinematic analysis (3)
- Knees (3)
- Legs (3)
- Macrophages (3)
- Medical risk factors (3)
- Morbidity (3)
- Multimorbidity (3)
- Multivariate analysis (3)
- NK cells (3)
- NoxO1 (3)
- PCR (3)
- Pain (3)
- Polypharmacy (3)
- acetaminophen (3)
- aging (3)
- angiogenesis (3)
- bevacizumab (3)
- caspase-2 (3)
- ceramides (3)
- cirrhosis (3)
- colorectal cancer (3)
- complement (3)
- cytokines (3)
- dental profession (3)
- dentate gyrus (3)
- dentist (3)
- drug resistance (3)
- electrolytic cleaning (3)
- entropy (3)
- exercise (3)
- flow cytometry (3)
- glioma (3)
- growth (3)
- immunity (3)
- information theory (3)
- innate immunity (3)
- invasion (3)
- invasive fungal disease (3)
- meningioma (3)
- metabolism (3)
- metastasis (3)
- mitochondria (3)
- monocytes (3)
- mortality (3)
- mutual information (3)
- natural killer cell (3)
- neuroblastoma (3)
- neuropathic pain (3)
- osteoarthritis (3)
- p21 (3)
- periimplantitis (3)
- physical activity (3)
- preeclampsia (3)
- proteomics (3)
- public health (3)
- quality of life (3)
- questionnaire (3)
- reactive oxygen species (3)
- regeneration (3)
- systematic biopsy (3)
- trauma (3)
- tumor progression (3)
- vitamin D (3)
- working memory (3)
- ADHD (2)
- ATM (2)
- ATP-citrate lyase (2)
- Angiogenesis (2)
- Angiography (2)
- Asphyxia (2)
- Ataxia telangiectasia (2)
- BCL6 (2)
- BPH (2)
- Biomarker (2)
- Birth weight (2)
- Blood (2)
- Borrelia (2)
- Brain metastasis (2)
- Breast cancer (2)
- Breast tumors (2)
- C-reactive protein (2)
- CC16 (2)
- CD44 (2)
- CDKN1A (2)
- CIK cells (2)
- CLP (2)
- COMP (2)
- CUELA (2)
- Cancer chemotherapy (2)
- Candida (2)
- Cell binding (2)
- Cell differentiation (2)
- Cesarean section (2)
- Chemotherapy (2)
- Citation analysis (2)
- Cohort studies (2)
- Crohn's disease (2)
- Crohn’s disease (2)
- Cuela (2)
- Cytokines (2)
- Density equalizing mapping (2)
- Dentist (2)
- Depression (2)
- Diagnostic medicine (2)
- Ears (2)
- G2A (2)
- GPCR (2)
- HDAC (2)
- HIV (2)
- Holmes tremor (2)
- IBD (2)
- Inflammatory bowel disease (2)
- Intensive care units (2)
- Ischemia (2)
- Jaw (2)
- LSCC (2)
- Lesions (2)
- MICA (2)
- Malaria (2)
- Markovianity (2)
- Medical education (2)
- Mental health and psychiatry (2)
- Messenger RNA (2)
- Methicillin-resistant Staphylococcus aureus (2)
- Mouse models (2)
- Musculoskeletal disorder (2)
- Myalgia (2)
- NADH dehydrogenase (2)
- NADPH oxidase (2)
- NAFLD (2)
- NASH (2)
- NK cells (2)
- Neonates (2)
- Neutropenia (2)
- Normal distribution (2)
- Nox1 (2)
- OXA-48 (2)
- Obstetrics and gynecology (2)
- Patients (2)
- Physicians (2)
- Portal hypertension (2)
- Portal veins (2)
- Postural control (2)
- Preterm birth (2)
- Prognosis (2)
- Protease inhibitor therapy (2)
- Psychology (2)
- Quality of life (2)
- Questionnaire (2)
- RNF4 (2)
- ROS (2)
- Regression analysis (2)
- Reliability (2)
- Research architecture (2)
- Surgery (2)
- T cell (2)
- T cells (2)
- Torque (2)
- Transcription factors (2)
- Treg cell (2)
- Ulcerative colitis (2)
- Vitamin D (2)
- acetyl-CoA (2)
- additives (2)
- adhesion (2)
- adipose-derived mesenchymal stem cells (2)
- air flow (2)
- alcohol (2)
- anaemia (2)
- anal cancer (2)
- anticonvulsants (2)
- antiviral therapy (2)
- ascites (2)
- atherosclerosis (2)
- augmentation (2)
- bibliometrics (2)
- bibliometry (2)
- bio imaging (2)
- bioluminescence (2)
- blood (2)
- borrelia (2)
- calretinin (2)
- cancer stem cells (2)
- carbapenemases (2)
- cardiac surgery (2)
- cell cycle (2)
- cervical cancer (2)
- chemotherapy (2)
- chemotherapy resistance (2)
- cholesterol (2)
- classical Hodgkin lymphoma (2)
- coagulopathy (2)
- cochlear implant (2)
- colon cancer (2)
- colon carcinoma cells (2)
- colorectal carcinoma (2)
- complications (2)
- concordance (2)
- corona virus (2)
- coronavirus (2)
- cyclosporin A (2)
- dance (2)
- dendritic cells (2)
- dental assistants (2)
- dental education (2)
- dental implant (2)
- dentists (2)
- depression (2)
- diet (2)
- disintegration (2)
- elderly (2)
- encoding (2)
- exosomes (2)
- extracellular vesicles (2)
- fMRI (2)
- female subjects (2)
- fibroblasts (2)
- forensic entomology (2)
- functional genomics (2)
- fusion (2)
- fusion biopsy (2)
- gender (2)
- gene expression (2)
- gene regulation (2)
- histology (2)
- histone acetylation (2)
- human genomics (2)
- imaging (2)
- immune evasion (2)
- immunohistochemistry (2)
- inflammatory bowel disease (2)
- integrin (2)
- interleukin-4 (2)
- iron deficiency (2)
- iron metabolism (2)
- irradiation (2)
- knowledge discovery (2)
- layer-specificity (2)
- lipoxygenase (2)
- liver damage (2)
- liver fibrosis (2)
- liver transplantation (2)
- lung cancer (2)
- lyme disease (2)
- maintenance (2)
- methylprednisolone (2)
- miR-181 (2)
- mouse (2)
- mucormycetes (2)
- multimorbidity (2)
- multinucleated giant cells (2)
- musculoskeletal (2)
- mycophenolic acid (2)
- natural killer cells (2)
- neurogenesis (2)
- next generation sequencing (NGS) (2)
- occupational health (2)
- olfaction (2)
- oxidative phosphorylation (2)
- oxidative stress (2)
- palatal tremor (2)
- patient (2)
- patients (2)
- perforant path transection (2)
- phagocytes (2)
- plasmid (2)
- polypharmacy (2)
- primary care (2)
- primary cilium (2)
- primary immunodeficiency (2)
- proteome (2)
- qRT-PCR (2)
- qualitative research (2)
- quantitative MRI (2)
- re-osseointegration (2)
- regulatory T cell (2)
- renal cell cancer (2)
- renal cell carcinoma (2)
- renal tubular epithelial cells (2)
- respiratory chain (2)
- schizophrenia (2)
- second-hand smoke (2)
- secretion (2)
- seizure (2)
- selection (2)
- sex (2)
- signal transduction (2)
- sound-induced flash illusion (2)
- sphingosine 1-phosphate (2)
- sphingosine 1-phosphate receptor (2)
- spirochetes (2)
- standard value (2)
- starvation (2)
- stationarity (2)
- surgery (2)
- survivin (2)
- tissue engineering (2)
- total hip replacement (2)
- toxicity (2)
- tracking (2)
- transfusion (2)
- trophoblast (2)
- trophoblasts (2)
- tumor growth (2)
- tumor-associated macrophages (2)
- uteroglobin (2)
- (novel) brominated flame retardants ((N)BFR) (1)
- 16 segment AHA model (1)
- 16p11.2 (1)
- 17-AAG (1)
- 2-deoxyglucose (2-DG) (1)
- 3D gait analysis (1)
- 5' UTR (1)
- A-FFIP (1)
- AB-serum (1)
- ABCB1 (1)
- ABCC1 (1)
- ACLF (1)
- ADGRE1 (1)
- ADHD differential diagnosis (1)
- AICAR (1)
- AKT signaling (1)
- ALD (1)
- AML – acute myeloid leukemia (1)
- AMPK (1)
- APRI (1)
- ASAP (1)
- ASD-specific (1)
- AU-rich element (1)
- Acute Myeloid Leukemia (1)
- Addison’s disease (1)
- Adenocarcinoma (1)
- Adenylyl cyclase (1)
- Adhesion (1)
- Adverse drug reaction (1)
- Ag-RDT (1)
- Aging (1)
- Akaike information criterion (AIC) (1)
- Allergic asthma (1)
- Amitriptyline (1)
- Amniotic fluid (1)
- Anal cancer (1)
- Anamneseerhebung (1)
- Anesthesia, Intravenous (1)
- Aneurysms (1)
- Animal wings (1)
- Anosmia (1)
- Anterior cruciate ligament reconstruction (1)
- Anticholinergic (1)
- Anticoagulant therapy (1)
- Anticoagulants [MeSH] (1)
- Anticoagulation (1)
- Antiplatelet therapy (1)
- Antiretroviral therapy (1)
- Antiviral therapy (1)
- Anxiety (1)
- Aortic stiffness (1)
- Arms (1)
- Aromatase Inhibitors (1)
- Ascites (1)
- Aspergillus fumigatus (1)
- Aspergillus species (1)
- Ataxia-telangiectasia (1)
- Atherosclerosis (1)
- Atm (1)
- Atrial fibrillation (1)
- Attention-deficit / hyperactivity disorder (1)
- Attitude (1)
- Audio equipment (1)
- Audio signal processing (1)
- Audiology (1)
- Aurora A (1)
- Australia (1)
- Autism (1)
- Autism spectrum disorder (1)
- Automated Tube Potential Selection (1)
- Automatic Environmental Tobacco Smoke Emitter (1)
- Axons (1)
- B cell subpopulations (1)
- B-cell antigen receptor (1)
- B.1.1.7 (1)
- B.1.617.1 (1)
- B.1.617.2 (1)
- BIRC5 (1)
- BMNC (1)
- BNT2b2 (1)
- BPO (1)
- BRAF (1)
- BRUCE (1)
- Bayesian inference (1)
- Bee venom allergy (1)
- Benefit (1)
- Bibliometric analysis (1)
- Big five (1)
- Birth (1)
- Bleeding (1)
- Blood groups (1)
- Blood plasma (1)
- Bloodstream infections (1)
- Body limbs (1)
- Bone marrow (1)
- Borrelia miyamotoi (1)
- Bradycardia (1)
- Bright light therapy (1)
- Bronchial inflammation (1)
- C. elegans (1)
- CAD/CAM (1)
- CD19 (1)
- CD271 (1)
- CD3/CD19 depletion (1)
- CD36 (1)
- CD41 (1)
- CD45RA naïve lymphocytes (1)
- CD62P (1)
- CD74 (1)
- CD8+ T lymphocytes (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CDK2 (1)
- CHA2DS2-VASc-score (1)
- CPE (1)
- CPT1A (1)
- CRISPR/Cas9 (1)
- CRM (1)
- CRM1 (1)
- CRP (1)
- CRPC (1)
- CSC marker (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- Caco-2 cells (1)
- Canada (1)
- Cancer (1)
- Cancer Staging (1)
- Cancer detection and diagnosis (1)
- Cannabis (1)
- Carcinoma, Ductal, Breast (1)
- Cardiovascular epidemiology (1)
- Cardiovascular magnetic resonance (1)
- Case management (1)
- Case management [MeSH] (1)
- Cell distribution (1)
- Cell motility (1)
- Cell signalling (1)
- Cell staining (1)
- Cellular stress responses (1)
- Central nervous system (1)
- Cerebrospinal fluid (1)
- Chemoradiotherapy (1)
- Child adiposity (1)
- Chondral Lesion (1)
- Chronic disease [MeSH] (1)
- Chronic hepatitis (1)
- Chronic intestinal failure (1)
- Chronic kidney disease (1)
- Citation (1)
- Clincial pharmacology (1)
- Co-morbidity (1)
- Cognitive impairment (1)
- Cognitive neurology (1)
- Colchicum (1)
- Cold hardiness (1)
- Cold tolerance (1)
- Colorectal cancer (1)
- Computed axial tomography (1)
- Computed tomography (1)
- Computed tomography imaging (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer hardware (1)
- Computer software (1)
- Computers (1)
- Conservative treatment (1)
- Constrained posture (1)
- Coronary artery disease (1)
- Cost-effectiveness analysis (1)
- Cre-recombinase (1)
- Critical care (1)
- Cryptococcus (1)
- CspA (1)
- CspZ (1)
- Cyp46a1 (1)
- Cytogenetics (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytoreductive nephrectomy (1)
- Cytoskeletal proteins (1)
- D-dimer (1)
- DBS (1)
- DC-NK cell interaction (1)
- DHA (1)
- DLPFC (1)
- DNA Damage (1)
- DNA damage (1)
- DNA damage response (1)
- DNA-binding proteins (1)
- DOMS (1)
- DST (1)
- Data processing (1)
- Data science (1)
- Deletion mutation (1)
- Dengue (1)
- Dengue fever (1)
- Density equalizing (1)
- Dental education (1)
- Dental implants (1)
- Dental phobia (1)
- Dental practice (1)
- Dental students (1)
- Dental training (1)
- Diabetes mellitus (1)
- Diagnostic accuracy (1)
- Diagnostic error (1)
- Diagnostic markers (1)
- Digestive system procedures (1)
- Digital workshops (1)
- Disabilities (1)
- Discs large (1)
- Distance to water (1)
- Distribution limits (1)
- Domestic animals (1)
- Double-blind placebo-controlled trial (1)
- Drug susceptibility testing (1)
- Drug therapy (1)
- Dual-Source CT (1)
- D’Amico classification (1)
- ECMO (1)
- EGFR (1)
- EGFRvIII mutation (1)
- EMR1 (1)
- EPA (1)
- ERK3/MAPK6 (1)
- ERM (1)
- Early intervention (1)
- Economic analysis (1)
- Economic benchmarks (1)
- Education (1)
- Elderly (1)
- Elevation (1)
- Ellipsoids (1)
- Emotional recognition (1)
- Emotions (1)
- EndMT (1)
- Endocrine cancer (1)
- Endometriosis (1)
- Endothelial cell (EC) (1)
- Endothelial cells (1)
- Endovascular aortic repair (1)
- England (1)
- Enterobacterales (1)
- Enterobacteriaceae (1)
- Enzyme regulation (1)
- Epidemiology (1)
- Epidermal growth factor receptor (1)
- Epidural abscess (1)
- Epidural block (1)
- Epileptic seizures (1)
- Epsilon (1)
- Ergonomics (1)
- Erythropoiesis (1)
- Estrogen Receptor Modulators (1)
- Etiology (1)
- Eutheria (1)
- Evidence based medicine (1)
- Evidence-based dentistry (1)
- Evidence-based medicine (1)
- Exercise (1)
- Exercise challenge (1)
- Exercise-induced asthma (1)
- Exhaled nitric oxide (1)
- Extracorporeal membrane oxygenation (1)
- Exudates and transudates (1)
- F4/80 (1)
- FFLU (1)
- FFPE (1)
- FIB-4 (1)
- FOXO3 (1)
- FOXO3a (1)
- Factor H (1)
- Factor analysis (1)
- Feasibility studies (1)
- Feedback (1)
- Fevers (1)
- Finevo (1)
- Five-Konzept (1)
- Flow cytometry (1)
- Forced expiratory volume in 1 s (1)
- Forensics (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Functional clustering (1)
- Functional electrical stimulation (1)
- Functional mitral regurgitation (1)
- Fusarium (1)
- GABA (1)
- GMP (1)
- GPR4 (1)
- GRK2 (1)
- GSK3α (1)
- GSK3β (1)
- Gait analysis (1)
- Galleria mellonella (1)
- Gastric cancer (1)
- Gastrointestinal (1)
- Gastrointestinal tract (1)
- Gender analysis (1)
- Gene prediction (1)
- General dental practice (1)
- Genetics (1)
- Genome annotation (1)
- Geographically weighted regression (GWR) (1)
- German people (1)
- Germany (1)
- Gesprächsführung (1)
- Gestational diabetes (1)
- Gleason Score (1)
- Gleason score (1)
- Gleason upgrading (1)
- Glioblastoma (1)
- Global health (1)
- Glucose Transporter Type 1 (1)
- Goserelin (1)
- Gram negative bacteria (1)
- GvHD (1)
- HBV (1)
- HBV reactivation (1)
- HCC (1)
- HCV treatment (1)
- HIFT (1)
- HLA class II (1)
- HLA peptidome (1)
- HNSCC (1)
- HOD (1)
- HODE (1)
- HOLEP (1)
- HPV (1)
- HSCT (1)
- HSV (1)
- HSV-1 (1)
- HSV-2 (1)
- HUVEC (1)
- Hashimoto’s thyroiditis (1)
- HbA1c (1)
- HeLa cells (1)
- Health care (1)
- Health economics (1)
- Health services research [MeSH] (1)
- Heart failure (1)
- Hedgehog (1)
- Hematopoietic stem cell transplantation (1)
- Hepatitis C virus (1)
- Hip (1)
- Histology (1)
- Hmox1 (1)
- HoLEP (1)
- Hodgkin lymphoma (1)
- Hospitals (1)
- Hsp90 inhibitor (1)
- HuR (1)
- Human (1)
- Human olfaction (1)
- Hydrocephalus (1)
- Hymenoptera venom immunotherapy (1)
- Hypertension (1)
- IFN-β (1)
- IHC (1)
- IKKε (1)
- IL-15 (1)
- IL-18BP (1)
- IL-1β (1)
- IL-21 (1)
- IL-27 cytokine (1)
- IL-33 (1)
- IL-6 (1)
- INR (1)
- IPS e.max system (1)
- IPSS (1)
- IRES translation (1)
- ISR (1)
- Image analysis (1)
- Immune cells (1)
- Immune suppression (1)
- Immunohistochemistry techniques (1)
- Immunology (1)
- Impella (1)
- Imrt (1)
- IncL (1)
- IncX (1)
- Incidence rate (1)
- Induced sputum (1)
- Infarction (1)
- Infectious disease epidemiology (1)
- Inferior vena cava thrombus (1)
- Inflammatory diseases (1)
- Injury Severity Score (ISS) (1)
- International normalized ratio (1)
- Internet (1)
- Intersectoral care (1)
- Interspecific competition (1)
- Intervention development (1)
- Intestinal failure-associated liver disease (1)
- Intravenous injections (1)
- Ireb2 (1)
- Iron Overload (1)
- Iron chelation (1)
- Joint loading (1)
- Jumping (1)
- K-homology RNA-binding domain (1)
- KAP (1)
- KCNQ1 (1)
- KPS (1)
- Kappa (1)
- Karyotypes (1)
- Keap1-Nrf2 (1)
- Ketogenic Diet (1)
- Ki-67 (1)
- Kidney transplant recipients (1)
- Kinematic posture analysis (1)
- Knowledge (1)
- Kommunikation (1)
- Kupffer cells (1)
- Kynurenine (1)
- LAMTOR2 (1)
- LC3 I/II (1)
- LCH (1)
- LC–MS/MS (1)
- LDL (1)
- LIR interaction, (1)
- LIVIN (1)
- LM11A 31 (1)
- LQTS (1)
- Laboratory techniques and procedures (1)
- Lafora disease (1)
- Langerhans cell histiocytosis (1)
- Lecture (1)
- Left hemisphere (1)
- Leigh syndrome (1)
- Lernzuwachs (1)
- Light sheet fluorescence microscopy (1)
- Linear regression analysis (1)
- Liver fibrosis (1)
- Liver transplantation (1)
- Livestock (1)
- LncRNA - long noncoding RNA (1)
- Local climate (1)
- Longchain polyunsaturated fatty acids (1)
- Luciferase (1)
- Lyme disease (1)
- Lymphangioleiomyomatosis (1)
- Lymphoma (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MAGGIC score (1)
- MAIT cell (1)
- MCAO (1)
- MCI (1)
- MEDIC (1)
- MEIS (1)
- MEIS2 (1)
- MMP14 (1)
- MMP2 (1)
- MRI (1)
- MRI patterns of gliomas (1)
- MRP4 (1)
- Machine learning (1)
- Machine learning algorithms (1)
- Machine-learning (1)
- Mammalian target of rapamycin (1)
- Mapping (1)
- Marker genes (1)
- Marsupials (1)
- Mastoiditis (1)
- Mechanisms of disease (1)
- Meckel’s diverticulum (1)
- Medical Physics: Diagnostic (1)
- Medical communication (1)
- Medical ethics (1)
- Medical research (1)
- Medical traineeship (1)
- Medication changes (1)
- Medicine and health sciences (1)
- Membrane staining (1)
- Meta-analysis (1)
- Metabolism, Inborn Errors (1)
- Metalloproteases (1)
- Metastasis (1)
- Metastatic renal cell carcinoma (1)
- Metastatic tumors (1)
- Methods (1)
- Michael acceptor (1)
- Micro-CT (1)
- Microalgae (1)
- Microglial cells (1)
- Microphones (1)
- MitraClip (1)
- Molecular medicine (1)
- Molecular neuroscience (1)
- Monocytes and macrophages (1)
- Monosaccharide Transport Proteins (1)
- Morphometry (1)
- Mortality (1)
- Mucomaix® matrix (1)
- Multi-modal feedback (1)
- Multidetector Computed Tomography (1)
- Multimedication (1)
- Multiplate (1)
- Multiple chronic conditions (1)
- Multiple-indication review (1)
- Musculoskeletal mechanics (1)
- Mycobacteria (1)
- Mycobacterium avium complex (1)
- Myocardial perfusion (1)
- Myocardial revascularization (1)
- Myocardial segmentation (1)
- Myocarditis (1)
- N2 (1)
- N501Y (1)
- NADPH oxidase 4 (1)
- NDBI (1)
- NF-ĸB (1)
- NF-κB pathway (1)
- NF-кB (1)
- NIRS (1)
- NK cell (1)
- NK receptors (1)
- NK-92 (1)
- NKT cell (1)
- NLRP3 inflammasomes (1)
- NS3 protease inhibitor (1)
- NTM (1)
- Native T1 mapping (1)
- Necrosis (1)
- Negative staining (1)
- Nek1 (1)
- Neoplasms (1)
- Neuroendocrine cancer (1)
- Neuroimaging (1)
- Neurons (1)
- Neuropathic pain (1)
- Neuropsychological testing (1)
- Neuropsychology (1)
- Next-generation sequencing (1)
- Niche differentiation (1)
- Nimotuzumab (1)
- Non-small cell lung cancer (1)
- Non-tuberculous mycobacteria (1)
- Non-urothelial (1)
- Nonpenetrating (1)
- Nontuberculous mycobacteria (1)
- Nordic questionnaire (1)
- Notch (1)
- Nrf2 (1)
- OGR1 (1)
- OGTT (1)
- OHIP-G14 (1)
- OHRQoL (1)
- OSA (1)
- OXA-484 (1)
- Obesity (1)
- Older adults (1)
- Olfactory diagnostics (1)
- Opossums (1)
- Opportunistic infections (1)
- Opsoclonus-myoclonus syndrome (1)
- Optogenetics (1)
- Oral and maxillofacial surgery (1)
- Oral anticoagulation (1)
- Ordinary least squares (OLS) (1)
- Orthodontist (1)
- Orthopaedics (1)
- OspE (1)
- Osteoarthritis (1)
- Outpatients (1)
- Overwintering (1)
- PBX (1)
- PBX1 (1)
- PD-L1 (1)
- PEI (1)
- PF-06273340 (1)
- PINK1 (1)
- PKA (1)
- PKCε (1)
- PML (1)
- POCT (1)
- PSA (1)
- PTM (1)
- PYGL (1)
- Paediatric research (1)
- Pancreatic neuroendocrine tumor (1)
- Paraneoplastic neurological syndromes (1)
- Parenteral nutrition (1)
- Parkinson’s disease (1)
- Patellofemoral Joint (1)
- Patient and public Involvement (1)
- Patient education (1)
- Patient knowledge (1)
- Patient participation (1)
- Patient safety (1)
- Patient satisfaction (1)
- Patterns of care (1)
- Peer-feedback (1)
- Per1−/−-mice (1)
- Percutaneous coronary intervention (1)
- Personality (1)
- Pgrmc1 (1)
- Pharm-fMRI (1)
- Pharmacometrics (1)
- Pharyngeal reflex (1)
- Phenotypic plasticity (1)
- Phospholipids (1)
- Photoreceptors (1)
- Phylogenetic analysis (1)
- Physical environment (1)
- Physiology (1)
- Plasmapheresis (1)
- Platelet-rich fibrin (1)
- Platelets (1)
- Point-of-care testing (1)
- Poly-Pore (1)
- PolySUMOylation (1)
- Post-traumatic stress disorder (1)
- Practice (1)
- Prediction (1)
- Prevalence (1)
- Primary care (1)
- Primary health care (1)
- Primary health care [MeSH] (1)
- Probability density (1)
- Probability distribution (1)
- Professional dance (1)
- Prostaglandin (1)
- Prostate cancer (1)
- Prosthetic rehabilitation (1)
- Protein translation (1)
- Prototypes (1)
- Psychological stress (1)
- Public and occupational health (1)
- Public health (1)
- Publication (1)
- Publication output (1)
- QbTest® (1)
- Quantitative features (1)
- Quantra (1)
- Quinolinate phosphoribosyltransferase (1)
- Quinolinic acid (1)
- RITA (1)
- RNA (1)
- RNA binding proteins (1)
- RNA chaperone (1)
- RNA extraction (1)
- RNA isolation (1)
- RNA sequencing (1)
- RNA therapeutics (1)
- RNA therapy (1)
- RNA-binding protein (1)
- RNAi and CRISPR screens (1)
- ROC analysis (1)
- Radiation exposure (1)
- Rainfall (1)
- Randomised trial (1)
- Rare Diseases (1)
- Reactive oxygen species (1)
- Regret (1)
- Regulatory networks (1)
- Renal vein thrombus (1)
- Research design (1)
- Resource competition (1)
- Respiratory Syncytial Virus (1)
- Respiratory infections (1)
- Restricted posture (1)
- Retina (1)
- Ribosomes (1)
- Risk assessment (1)
- Rural area (1)
- Rush protocol (1)
- S1P (1)
- S1P lyase (1)
- S1P1–5 (1)
- S1PR1 (1)
- SARS-COV-2 (1)
- SCA2 (1)
- SENP6 (1)
- SF-36 (1)
- SGPL1 knockout cell line (1)
- SH-SY5Y neuroblastoma cells (1)
- SKALE score (1)
- SLC6a3 (1)
- SLC7A11 (1)
- SMOC1 (1)
- SNORD95 (1)
- ST2L (1)
- STAMPE2 (1)
- STAT3 (1)
- STIR (1)
- SUD (1)
- SUMO (1)
- SUMO chains (1)
- SW480 cells (1)
- Sarcopenia (1)
- Science structure (1)
- Scientists (1)
- Scientometric analysis (1)
- Scientometrics (1)
- Scientometry (1)
- Seattle heart failure model (1)
- Sensory perception (1)
- Sequence alignment (1)
- Sequence motif analysis (1)
- Serum biomarker (1)
- Sholl analysis (1)
- Short bowel syndrome (1)
- Side effects (1)
- Simulated patients (1)
- Skeletal joints (1)
- Slc11a2 (1)
- Slc25a37 (1)
- Smart nebulizer (1)
- Social research (1)
- Social sciences (1)
- Software tool (1)
- Software tools (1)
- Specimen preparation and treatment (1)
- Speech signal processing (1)
- Spinal injuries (1)
- Spinocerebellar ataxia type 2 (1)
- Sport (1)
- Sports and exercise medicine (1)
- Squamous cell carcinoma (1)
- StUbL (1)
- Stakeholder participation (1)
- Statistical analysis (1)
- Statistical data (1)
- Stenotrophomonas maltophilia (1)
- Stereotactic radiosurgery (1)
- Strength training (1)
- Stress and resilience (1)
- Stroke (1)
- Sub-segmentation (1)
- Sub-zero exposure (1)
- Suicide (1)
- Sumatra (1)
- Superoxide (1)
- Surgical and invasive medical procedures (1)
- Surgical education (1)
- Surgical oncology (1)
- Survey (1)
- Surveys (1)
- Survivin (1)
- Synapses (1)
- Systematic reviews (1)
- T cell receptor (1)
- T-cell development (1)
- T-cell receptor (1)
- T-cell receptor (TCR) (1)
- T-lymphocytes (1)
- TACE (1)
- TALE-homdomain protein (1)
- TAPSE (1)
- TBK1 (1)
- TDAG8 (1)
- TGF-β1 (1)
- TGR(mREN2)27 (1)
- TIMP2 (1)
- TLR (1)
- TNF inhibitors (1)
- TNF-α (1)
- TP53 (1)
- TP53-induced glycolysis and apoptosis regulator (1)
- TRIM25 (1)
- TRIMs (1)
- TRPM8 (1)
- TSP-4 (1)
- TURP (1)
- Targeted therapy (1)
- Tet-inducible system (1)
- Tfrc (1)
- Thoracic aortic aneurysm (1)
- Thrombosis (1)
- Thromboxane (1)
- Total hip arthroplasty (1)
- Toxicity (1)
- Transcription (1)
- Transcriptional control (1)
- Translation initiation (1)
- Translational research (1)
- Transportation (1)
- Trk (1)
- TrkC (1)
- Tubers (1)
- Tularemia (1)
- Tumor infiltrating lymphocytes (1)
- ULBP4 (1)
- Ultra microscopy (1)
- Ultra-rush protocol (1)
- Ultrasonic nebulizer (1)
- Umbilical cord (1)
- Uncertainty (1)
- Undergraduate training (1)
- United States (1)
- Urethral cancer (1)
- VIM (1)
- Vacuoles (1)
- Validation (1)
- Validity (1)
- Variant histology (1)
- Vasculogenesis (1)
- Veins (1)
- Vertebral body (1)
- Vespid venom allergy (1)
- Viral load (1)
- Virtual patients (1)
- Vitamin D deficiency (1)
- Vmem (1)
- Volumetric analysis (1)
- Warburg effect (1)
- Water chemistry (1)
- Western diet (1)
- White blood cells (1)
- Winter survival (1)
- Work shadowing (1)
- Workstation comparison (1)
- Wound healing (1)
- Wounds (1)
- XIAP (1)
- YM155 (1)
- Yellow fluorescent protein (1)
- Zoonosis (1)
- Zoopotentation (1)
- Zooprophylaxis (1)
- Zymosan-induced peritonitis (1)
- academic (1)
- accident (1)
- acetylation (1)
- acetylcholinesterase (1)
- acoustic radiation force impulse imaging (1)
- acquired drug resistance (1)
- actin dynamics (1)
- activities of daily life (1)
- acute inflammation (1)
- acute kidney injury (1)
- acute lung injury (1)
- acute lung injury (ALI) (1)
- acute lymphoblastic leukemia (1)
- acute pain (1)
- acute respiratory distress syndrome (1)
- acute-on-chronic liver failure (1)
- acute-on-chronic liver failure (ACLF) (1)
- adenosine (1)
- adenosine receptors (1)
- adipocytes (1)
- adiponectin (1)
- adipose-derived mesenchymal stem/stromal cells (1)
- adipose-derived stem cells (1)
- adipose-derived stromal/stem cells (1)
- adoptive cancer immunotherapy (1)
- adoptive immunotherapy (1)
- adrenal insuffciency (1)
- adult neurogenesis (1)
- adverse reaction (1)
- affective disorder (1)
- affective disorders (1)
- aged (1)
- ageing (1)
- agent-based models (1)
- air pollution (1)
- airborne bacteria (1)
- albumin (1)
- alcoholic hepatitis (1)
- algorithm (1)
- allergy (1)
- allogeneic stem cell transplantation (1)
- alpha-synuclein (1)
- alpharetroviral vector (1)
- amlexanox (1)
- amyotrophic lateral sclerosis (ALS) (1)
- analgesics (1)
- anaplastic large cell lymphoma (1)
- anemia (1)
- angioedema control test (1)
- angiography (1)
- animal model (1)
- anti-angiogenic therapy (1)
- anti-cancer therapy (1)
- anti-tumor activity (1)
- antiadhesive composites (1)
- antibacterial composites (1)
- antibiotic therapy (1)
- antibodies (1)
- antifibrotic therapy (1)
- antifungal activity (1)
- antifungal combination therapy (1)
- antifungal host response (1)
- antifungal therapy (1)
- antimicrobial stewardship (1)
- antireflux surgery (1)
- antiviral (1)
- antiviral drugs (1)
- apical constriction (1)
- apical junction (1)
- apical polarity (1)
- arachidonate 12/15-lipoxygenase (Alox12/15) (1)
- arachidonate 15-lipoxygenase (1)
- arachidonic acid (1)
- architecture (1)
- aromatics (1)
- articular cartilage (1)
- aspiration (1)
- aspirin (1)
- assembly (1)
- assembly factor (1)
- associative memory (1)
- asthma (1)
- astrocytes (1)
- astrocytoma (1)
- ataxia score (1)
- atopy (1)
- attachment (1)
- attention (1)
- attention deficit hyperactivity disorder (1)
- auditory (1)
- authorship (1)
- autoimmunity (1)
- automatic environmental tobacco smoke emitter (1)
- automatic scene classification (1)
- autopsy (1)
- back scan (1)
- bacterial translocation (1)
- bacterial viability (1)
- bacterium (1)
- ball (1)
- ballet (1)
- basal cell carcinoma (1)
- basilar artery occlusion (BAO) (1)
- best medical treatment (1)
- beta-band activity (1)
- beta-lactamases (1)
- bilateral tDCS (1)
- binary search procedure (1)
- bioactive lipids (1)
- bioactivity (1)
- bioavailability (1)
- biofilm (1)
- biologics (1)
- biologization (1)
- biomarkers (1)
- biomolecular analysis (1)
- biopsy (1)
- biopsy naïve (1)
- bladder neck stenosis (1)
- blended learning (1)
- blood concentrates (1)
- blood culture (1)
- blood pressure (1)
- blood-brain barrier (1)
- blow fly (1)
- body mass index (1)
- body posture (1)
- body sway (1)
- body weight distribution (1)
- bone damage (1)
- bone healing (1)
- bone marrow mononuclear cells (1)
- bone tissue (1)
- bone-regeneration (1)
- bone–implant interface (1)
- borrelia mayonii (1)
- brain imaging (1)
- brain infection (1)
- brain phosphorylome (1)
- brain shift (1)
- brain tumor (1)
- brainstem (1)
- burden of disease (1)
- butyrylcholinesterase (1)
- bypass (1)
- cAMP (1)
- cIAP1/2 (1)
- cadherin (1)
- calbindin (1)
- calcitriol (1)
- cancer and drug vulnerabilities (1)
- cancer cell metabolism (1)
- cancer immunobiology (1)
- cancer metastases (1)
- cancer specific survival (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- canonical (1)
- car indoor (1)
- carbapenem resistance (1)
- carbon oxides (COx) (1)
- carcinoma (1)
- cardiac differentiation (1)
- cardiac regeneration (1)
- cardiac reprogramming (1)
- cardiomyocyte apoptosis (1)
- cardiomyocyte proliferation (1)
- cardiothoracic surgery (1)
- cardiovascular disease (1)
- case reports (1)
- caspase 8 (1)
- caspase-8 (1)
- castration resistance (1)
- catheter removal (1)
- cdk (1)
- cell adhesion (1)
- cell and focal adhesion (1)
- cell culture (1)
- cell cycle arrest (1)
- cell cycling (1)
- cell fusion (1)
- cell growth (1)
- cell motility (1)
- cell proliferation (1)
- cell survival (1)
- cell survival mechanisms (1)
- cellular reaction (1)
- cellular response (1)
- cellular therapies (1)
- central nervous system (1)
- central spasticity (1)
- centrifugation (1)
- ceramide (1)
- cerebellum (1)
- cerebral imaging (1)
- cerebral radiation necrosis (1)
- chaperone-mediated autophagy (1)
- chaperones (1)
- chelation therapy (1)
- chemokine (1)
- chemokine receptors (1)
- chemoprotection (1)
- chemoradiotherapy (1)
- chemoresistance (1)
- chemotaxis (1)
- chemotherapeutic drug resistance (1)
- chest injury (1)
- chest trauma (1)
- chimeric antigen receptor (1)
- chloroplasts (1)
- cholangiocarcinoma (1)
- cholinesterase (1)
- chronic granulomatous disease (1)
- chronic hepatitis C (1)
- chronic inflammation (1)
- cigarette smoke (1)
- cigarette strength (1)
- citation (1)
- classification (1)
- classification of bone defects (1)
- clinical research (1)
- clinical trial (1)
- clopidogrel (1)
- cluster analysis (1)
- cluster-randomized controlled trial (1)
- cluttering (1)
- coagulation (1)
- cochlear implants (1)
- cognition (1)
- cognitive deficits (1)
- cognitive functions (1)
- cognitively stimulating leisure activities (1)
- collagen (1)
- collagen I (1)
- collagen-based biomaterial (1)
- collagen-based matrix (1)
- collective cell migration (1)
- colon (1)
- colorectal cancer (CRC) (1)
- combined immunodeficiency (1)
- comorbidity (1)
- complex systems (1)
- complexity theory (1)
- complexome profiling (1)
- computational functional genomics (1)
- computational knowledge-discovery (1)
- computational techniques (1)
- confinement (1)
- congenital diaphragmatic hernia (1)
- connective tissue (1)
- connectivity (1)
- contamination (1)
- continuous performance test (1)
- contralateral delay activity (1)
- controlled nuclear import (1)
- cooling period (1)
- coronary (1)
- coronavirus disease 2019 (1)
- cortex, gray matter (1)
- covalent drugs (1)
- crime scene (1)
- critical care (1)
- critical-size defect (1)
- criticality (1)
- cryopreservation (1)
- cuticular hydrocarbons (1)
- cyclin D1 (1)
- cyclin Y (1)
- cyclins (1)
- cyclophosphamide (1)
- cystic fibrosis (1)
- cytarabin (1)
- cytokine storm (1)
- cytokine, angiogenesis (1)
- cytotoxic lymphocytes (1)
- cytotoxicity (1)
- daily activity protocols (1)
- dance teacher (1)
- data repositories (1)
- death rates (1)
- death receptor (1)
- debris (1)
- declaration of tobacco ingredients (1)
- decompensated liver cirrhosis (1)
- deep sedation (1)
- deferred treatment (1)
- delayed treatment (1)
- delta (1)
- dementia (1)
- demineralized bone matrix (1)
- dendrite morphogenesis (1)
- density equalizing mapping (1)
- dental assistant (1)
- dental health professional (1)
- desensitization (1)
- development (1)
- dexamethasone (1)
- diabetes (1)
- diabetes mellitus (1)
- diabetes therapy (1)
- diagnostics (1)
- dietary assessment (1)
- differentiated thyroid carcinoma (1)
- diffusion tensor imaging (1)
- digital age determination (1)
- dihydrocannabidiol (1)
- dihydroceramides (1)
- dimethylfumarate (1)
- diphtheria toxin (1)
- direct-acting antivirals (1)
- discoidin domain-containing receptor (1)
- disease-free survival (1)
- disordered iron metabolism (1)
- dissemination (1)
- diuretics (1)
- dog study (1)
- dopamine transporter (1)
- doublecortin (1)
- downgrading (1)
- doxycycline (1)
- drug (1)
- drug screening (1)
- drug–drug interactions (1)
- drug–gene interactions (1)
- drug–g–gene interactions (1)
- dual antiplatelet therapy (1)
- dynamic causal modeling (1)
- dysphagia (1)
- eNPP2 (1)
- early continence (1)
- early detection (1)
- early loss (1)
- early onset (1)
- ecological momentary assessment (1)
- ectopic pregnancy (1)
- efferocytosis (1)
- efficacy (1)
- effort (1)
- eicosanoids (1)
- electrode design (1)
- electron transfer (1)
- electrophilic fatty acids (1)
- electrophysiology (1)
- eligibility (1)
- elite athletes (1)
- eltrombopag (1)
- emergency care (1)
- emergent self-organizing maps (1)
- endocannabinoids (1)
- endoplasmic reticulum (1)
- endothelial cell (1)
- endothelial nitric-oxide synthase (1)
- endourology (1)
- endovascular treatment (1)
- enterobacter infections; pseudomonas aeruginosa; epidemiology (1)
- entomological evidence (1)
- epidemics (1)
- epidermis (1)
- epigenetics (1)
- epileptic encephalopathies (1)
- epithelial-to-mesenchymal transition (EMT) (1)
- erastin (1)
- essential tremor (1)
- ethnicity (1)
- euthymic (1)
- everolimus (1)
- everyday life (1)
- ex vivo expansion (1)
- ex-Gaussian analysis (1)
- exertion (1)
- experimental pain models (1)
- expertise (1)
- exponential model (1)
- extracellular matrix (1)
- fNIRS (1)
- face-name association task (1)
- factor H (1)
- falls (1)
- false memory (1)
- fatigue (1)
- feasibility (1)
- feeder cells (1)
- female health (1)
- ferroportin (1)
- ferroptosis (1)
- fibrinolysis (1)
- fibrosis (1)
- fibrotest (1)
- fingolimod (1)
- first-line chemotherapy (1)
- fitness (1)
- fixed partial dentures (1)
- follow-up (1)
- forensics (1)
- fractional anisotropy (1)
- fractionation (1)
- fragile-X-associated tremor-ataxia syndrome (1)
- frequency of attacks (1)
- fresh frozen plasma (1)
- fronto-temporal lobar dementia (1)
- fronto-temporal-lobar-dementia (1)
- full-contour crown restorations (1)
- function (1)
- functional connectivity (1)
- functional magnetic resonance imaging (1)
- fundoplication (1)
- fungi (1)
- fungus (1)
- gadolinium enhancing lesion (1)
- galactomannan (1)
- gastroesophageal reflux (1)
- gender differences (1)
- gene expression analysis (1)
- gene signature (1)
- gene therapy (1)
- general anaesthesia (1)
- general practitioner (1)
- genetic diversity (1)
- genetic predisposition (1)
- genetics (1)
- geriatric patients (1)
- glial activation (1)
- glioma microenvironment (1)
- glucose metabolism (1)
- glycolysis (1)
- glycoproteins (1)
- graft-versus-host disease (1)
- graft-versus-tumor effect (1)
- granulomas (1)
- granulomatous inflammation (1)
- graph theory (1)
- growth inhibition (1)
- haploidentical (1)
- head and neck squamous cell carcinoma (1)
- head-and-neck cancer (1)
- healthcare workers (1)
- heart failure (1)
- heat (1)
- heat stress (1)
- hedgehog signaling (1)
- hedgehog signaling pathway (1)
- hematopoiesis (1)
- hematopoietic cell transplantation (1)
- hematopoietic stem and progenitor cells (1)
- hematopoietic stem cell transplantation (1)
- hemorrhagic transformation (1)
- hepatic steatosis (1)
- hepatic stellate cells (1)
- hepatitis B virus (1)
- hepatitis C virus (1)
- hepatitis E virus (1)
- hepatoblastoma (1)
- hepatocellular cancer (1)
- hereditary angioedema (1)
- heterogeneity (1)
- high molecular weight plasticizer (1)
- high throughput (1)
- high-dimensional data sets (1)
- high-throughput nucleotide sequencing (1)
- hippocampus (1)
- histological outcomes (1)
- histomorphometry (1)
- histone deacetylase (1)
- home visit (1)
- homeodomain protein (1)
- host cell interaction (1)
- host cell response (1)
- host-pathogen interaction (1)
- host-targeting antivirals (1)
- hostpathogen interaction (1)
- human Natural Killer cell (1)
- human antigen R (HuR) (1)
- human cytomegalovirus (1)
- human decellularized dermis (1)
- human subjects (1)
- humans (1)
- humectant agents (1)
- hybrid abutment (1)
- hydrogen peroxide (1)
- hyperglycemia (1)
- hyperlipidemia (1)
- hypoxia-induced cell death (1)
- hypoxia-inducible factor (1)
- idiopathic dystonia (1)
- image analysis (1)
- image-guided tissue acquisition (1)
- immune cells (1)
- immune checkpoint (1)
- immune defense (1)
- immune deficiency (1)
- immune host defense (1)
- immune infiltration (1)
- immune response (1)
- immunoglobulin superfamily (1)
- immunological research (1)
- immunosuppressive agent (1)
- immunosuppressive drug (1)
- in vitro models (1)
- in vivo dosimetry (1)
- in-cabin exposure (1)
- indoor air pollution (1)
- induced membrane (1)
- inducible gene expression (1)
- inducible nitric oxide synthase (1)
- inertial motion capture (1)
- infection control (1)
- infection model (1)
- infectivity (1)
- infiltration (1)
- inhibitor (1)
- inhibitor of apoptosis protein family (1)
- inhibitors (1)
- inosine (1)
- inositol signaling (1)
- insertion (1)
- insulin resistance (1)
- insurance data (1)
- integration (1)
- interferon (1)
- interferon type III (1)
- interleukin-1 (1)
- interleukin-18 (1)
- interleukin-22 (1)
- internal ribosomal entry site (IRES) (1)
- internet (1)
- interstitial multicatheter brachytherapy (1)
- intervention study (1)
- intestinal barrier (1)
- intoxication (1)
- intravenous iron therapy (1)
- intrinsic apoptosis (1)
- intrinsic drug resistance (1)
- invasive fungal infection (1)
- invasive growth (1)
- inverse stage migration (1)
- inflammation (1)
- ionomycin (1)
- iron chelation (1)
- iron chelator (1)
- iron chelators (1)
- iron deficiency anemia (1)
- iron homeostasis (1)
- iron overload versus deprivation (1)
- iron-trafficking (1)
- isocaloric ketogenic diet (1)
- jejunoileal atresia (1)
- joint contact forces (1)
- junctional adhesion molecule (1)
- juvenile myoclonic epilepsy (1)
- keratinocytes (1)
- kinematics (1)
- knee adduction moment (1)
- laceration (1)
- lentiviral vector (1)
- leukemia (1)
- leukocytes (1)
- leukopenia (1)
- levetiracetam (1)
- lichen extracts (1)
- light irradiation (1)
- linoleic acid metabolites (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipids (1)
- lipids inflammatory pain (1)
- lipofuscin (1)
- lipopolyplex (1)
- lipoxin A4 (1)
- liquid PRF (1)
- liquid-PRF (1)
- live cell imaging (1)
- live/dead staining (1)
- liver X receptor (1)
- liver cirrhosis (1)
- liver disease (1)
- liver injury (1)
- liver steatosis (1)
- lncRNA (1)
- local control (1)
- local recurrence (1)
- location (1)
- locator (1)
- long-term follow-up (1)
- long-term potentiation (1)
- long-term prophylaxis (1)
- longevity (1)
- low speed centrifugation concept (1)
- low-dose imaging (1)
- lung (1)
- lung disease (1)
- luteolin (1)
- lymphangiogenesis (1)
- lymphocyte (1)
- mGluR3 (1)
- mGluR5 (1)
- mHealth (1)
- mRNA stability (1)
- mRNA1273 (1)
- mTOR inhibition (1)
- mTORC1 (1)
- machine learning (ML) (1)
- machine-learning (1)
- magnetoencephalography (1)
- major depression (1)
- major depression (MD) (1)
- major depressive disorder (1)
- major depressive disorder (MDD) (1)
- malignancy (1)
- malignant glioma (1)
- mammary cancer (1)
- mammary carcinoma (1)
- markovianity (1)
- mass spectrometry (1)
- mast cells (1)
- maternal tobacco smoke (1)
- mathematical modeling (1)
- matrix metalloproteinase (1)
- matrix metalloproteinases (1)
- mean diffusivity (1)
- mechanism of action (1)
- medical error (1)
- medical risk factors (1)
- medication (1)
- medication management (1)
- medication review (1)
- medulloblastoma resection (1)
- melanoma (1)
- membrane potential (1)
- membrane-less organelles (1)
- membranous urethral stricture (1)
- memebrane (1)
- memory (1)
- menthol (1)
- merkel cell carcinoma (1)
- mesenchymal stem cell (1)
- mesenchymal stromal cell (1)
- mesenchymal stromal cells (1)
- meta-analysis (1)
- metabolic cancer therapy (1)
- metabolic liver disease (1)
- metabolic syndrome (1)
- metamorphosis (1)
- metastatic colorectal cancer (1)
- metastatic prostate cancer (1)
- metastatic urethral cancer (1)
- metformin (1)
- methacarn (1)
- methylation profiling (1)
- miR (1)
- miR-122 (1)
- miR-142-3p (1)
- miR-21 (1)
- miR-375 (1)
- mice (1)
- microbiome (1)
- microenvironment (1)
- microglia (1)
- microlesions (1)
- microsatellite instability (1)
- microtemporal processes (1)
- microtubular cytoskeleton (1)
- middle-aged (1)
- migration and invasion (1)
- mitochondrial disease (1)
- mobile air quality study (1)
- mobile phone (1)
- mold (1)
- molecular surveillance (1)
- monoclonal antibodies (1)
- monocyte chemotactic protein 1 (MCP-1) (1)
- monotype abutment (1)
- monsoon (1)
- morbidity (1)
- morphogenesis (1)
- morphometry (1)
- mortality analysis (1)
- motility (1)
- motor functions (1)
- mouse model (1)
- movement disorders (1)
- mpMRI (1)
- mtor (1)
- mucormycete (1)
- mucosal inflammation (1)
- multi-scale models (1)
- multidrug resistance (1)
- multifocal (1)
- multisensory integration (1)
- multivoxel pattern analysis (1)
- musculoskeletal disorders (1)
- musculoskeletal inflammation (1)
- musculoskeletal modeling (1)
- musculoskeletal pain (1)
- musculoskeletal system (1)
- myelodysplastic syndrome (1)
- myeloid cells (1)
- natural cytotoxicity (1)
- natural killer T cells (1)
- natural selection (1)
- naturalistic sample (1)
- ncRNA (1)
- neonate (1)
- nerve-sparing (1)
- network (1)
- neurexin (1)
- neurocognition (1)
- neuroimaging (1)
- neuronal avalanches (1)
- neuronal maturation (1)
- neuropsychological impairment (1)
- neurotrophins (1)
- next generation sequencing (1)
- next-generation sequencing (1)
- nitroalkylation (1)
- nitrogen oxides (NOx) (1)
- nodular sclerosis (1)
- noise intervention measures (1)
- non-aneurysmal SAH (1)
- non-canonical (1)
- non-classical adhesion molecule (1)
- non-coding RNA (1)
- non-invasive fibrosis assessment (1)
- non-linear dynamics (1)
- non-malignant hematological diseases (1)
- non-sensory bias (1)
- nonnucleoside polymerase inhibitor (1)
- nucleolus (1)
- nucleoredoxin (1)
- nucleotide metabolism (1)
- nursery schools (1)
- nutrient deprivation (1)
- nutrient endocytosis (1)
- occupational factors (1)
- older people (1)
- olfactory testing (1)
- omega-3 fatty acids (1)
- oncogenes (1)
- oncogenic signaling (1)
- one health (1)
- open field behavior (1)
- open-source (1)
- oral health (1)
- oral health burden (1)
- ordinary differential equations (ODE) (1)
- organisation of health services (1)
- organophosphate flame retardants (OFR) (1)
- organotypic culture (1)
- orientation (1)
- orthodontist (1)
- osteogenic sarcoma cells (1)
- ostium (1)
- ouabain (1)
- outside-in signaling (1)
- overall survival (1)
- overdenture (1)
- oxaliplatin (1)
- p-eIF2α (1)
- p14 (1)
- p21Cip1/CDKN1A (1)
- p47phox (1)
- p53 (1)
- p62 (1)
- p75 (1)
- paediatric (1)
- pain genetics (1)
- pain intensity (1)
- pain medication (1)
- particle size distribution (1)
- particulate matter (PM) (1)
- passive smoke (1)
- pathogen (1)
- patient blood management (1)
- patient preference (1)
- patient safety (1)
- patients' experience (1)
- patient’s decree (1)
- pediatric (1)
- pediatric epilepsy (1)
- pentose phosphate pathway (1)
- perineurium (1)
- perio-prosthetic joint infection (1)
- peritoneal macrophages (1)
- peritumoral edema (1)
- peritumoral edema zone (1)
- peroxisome proliferator-activated receptor (1)
- phage display (1)
- phagocytosis (1)
- pharmacist (1)
- pharmacodynamics (1)
- pharmacoepigenetics (1)
- pharmacogenetics (1)
- pharmacogenomics (1)
- pharmacokinetics (1)
- pharmacological data science (1)
- pharmacological plasticity (1)
- pharmacoresistance (1)
- phenoconversion (1)
- phenylephrine (1)
- phosphatases (1)
- pig (1)
- pilot study (1)
- pitch (1)
- pitch perception (1)
- placenta (1)
- planimetric measurement (1)
- plasma (1)
- plasminogen (1)
- platelet lysate (1)
- platelet-rich fibrin (1)
- platelet-rich-fibrin (1)
- platelets (1)
- point of care (1)
- point shear wave elastography (1)
- polarization (1)
- polo-like kinase 3 (1)
- poly(A)-tail (1)
- polyethylenimine (1)
- polymerase chain reaction (1)
- polyomavirus (MCPyV) (1)
- polyunsaturated fatty acid (1)
- porcine (1)
- portal hypertension (1)
- post-exercise hypotension (1)
- post-radiotherapy recurrence (1)
- post-transcriptional regulation (1)
- post-translational modifications (1)
- posterior circulation (1)
- posterior fossa masses (1)
- posterior fossa tumor (1)
- postmonsoon (1)
- postnatal neurogenesis (1)
- postoperative delirium (1)
- posttranslational modification (1)
- potassium channel (1)
- ppi1 (1)
- pre-emptive allogeneic hematopoietic stem cell transplantation (1)
- pre-professional (1)
- preconditioning (1)
- prediabetes (1)
- predictive coding (1)
- pretreatment (1)
- prevention (1)
- primary health care (1)
- primary prostate cancer (1)
- production (1)
- professional dance (1)
- prognosis (1)
- prognostic marker (1)
- progressive myoclonus epilepsy (1)
- prostaglandins (1)
- prostate neoplasm (1)
- proteasome (1)
- protein complexes (1)
- protein phosphorylation (1)
- protein–protein interaction (1)
- proton density (1)
- proton pump inhibitors (1)
- proton pumping (1)
- proton-sensing GPCR (1)
- proximal tubule cells (1)
- pseudomonas aeruginosa (1)
- psoriatic arthritis (1)
- psychological distress (1)
- pteridine (1)
- publication output (1)
- pulse-spreading harmonic complex (1)
- qPCR (1)
- qRT-PCR detection (1)
- quantitative magnetic resonance imaging (1)
- quantitative proteomics (1)
- quantum biology (1)
- quantum neurobiology (1)
- quiescence (1)
- race (1)
- radiation (1)
- radiation dosage (1)
- radiation dosimetry (1)
- radiation protection (1)
- radiation-induced (1)
- radical oxygen species (1)
- radical prostatecomy (1)
- radioimmunotherpay (1)
- radiosensitization (1)
- radiotherapy (1)
- radiotherapy resistance (1)
- radixin (1)
- rapamycin (1)
- rat (1)
- rat femur critical size defect (1)
- real-world data (1)
- recovery (1)
- red blood cells (1)
- reference values (1)
- regenerative medicine (1)
- regenerative therapy (1)
- regorafenib (1)
- regorafenib csf concentration (1)
- regulatory T helper cells (1)
- relaxometry (1)
- remodeling (1)
- renal failure (1)
- repeat biopsy (1)
- reperfusion injury (1)
- reproduction biology (1)
- resistance (1)
- resolution (1)
- resolution of inflammation (1)
- respiratory failure (1)
- rest period (1)
- resting‐state (1)
- reverberation (1)
- rheumatoid arthritis (1)
- ribavirin (1)
- risk factor (1)
- risk management (1)
- room simulation (1)
- rosetting T cells (1)
- rotational thromboelastometry (1)
- running (1)
- salvage mastectomy (1)
- salvage radical prostatectomy (1)
- sarcopenia (1)
- schizophrenia spectrum (1)
- sciatic nerve (1)
- scoping review (1)
- screening (1)
- screening routine (1)
- screening test (1)
- searchlight analysis (1)
- secondary cancer (1)
- secondary data analysis (1)
- secretome (1)
- segmentation (1)
- seizures (1)
- selectin (1)
- selective autophagy receptor (1)
- selfish genetic element (1)
- semiquinone (1)
- sensory organ development (1)
- sepsis (1)
- sequential decision-making (1)
- serum (1)
- severe acute respiratory syndrome coronavirus 2 (1)
- severe congenital neutropenia (1)
- severely injured (1)
- shedding (1)
- short bowel (1)
- short linear motifs (SLiMs) (1)
- siRNA delivery (1)
- siRNA/RNAi (1)
- sickle cell anemia (1)
- signal transducer and activator of transcription-1 (1)
- signaling (1)
- silk fibroin (1)
- simulation (1)
- simulation training (1)
- single-sided deafness (1)
- sirtuin1 (1)
- size of cigarettes (1)
- skin diseases (1)
- small bowel (1)
- smartphone-app (1)
- smoking in pregnancy (1)
- socio-economic influences (1)
- soluble MICA (1)
- sonic hedgehog signaling (1)
- sorafenib (1)
- sound analyses (1)
- spatial (1)
- spatial learning (1)
- specialized pro-resolving lipid mediators (SPMs) (1)
- species differences (1)
- speech perception (1)
- sphinganine 1-phosphate (1)
- sphingolipid (1)
- sphingolipids (1)
- sphingosine 1-phoshate (1)
- sphingosine 1-phosphate antagonistst/inhibitors (1)
- sphingosine 1-phosphate metabolism (1)
- sphingosine 1-phosphate signaling (1)
- sphingosine kinase (1)
- spike mutation (1)
- spinal infection (1)
- spirochete (1)
- splicing (1)
- split-mouth (1)
- sport (1)
- spreading (1)
- stakeholder analysis (1)
- statin treatment (1)
- statistical parametric mapping (1)
- steatosis (1)
- stem cell niche (1)
- stem cell transplantation (1)
- stem cells (1)
- sterol regulatory element binding protein-2 (1)
- stoma (1)
- stress granules (1)
- stress period (1)
- stretching (1)
- structure (1)
- structured care program (1)
- stuttering (1)
- subcutaneous fat (1)
- subpopulation (1)
- subventricular zone (1)
- success rate (1)
- survival (1)
- survival rate (1)
- swallowing (1)
- symptoms (1)
- synaptic plasticity (1)
- synaptic signaling (1)
- synoviocytes (1)
- synuclein (1)
- systemic inflammation (1)
- t-distributed stochastic neighbor embedding (1)
- tandem mass spectrometry (1)
- targeted biopsy (1)
- tauopathies (1)
- tauopathy (1)
- temozolomide (1)
- temsirolimus (1)
- test protocol (1)
- testosterone (1)
- tetracycline (1)
- tetrahydrocannabinol (1)
- thalassemia (1)
- therapy (1)
- therapy monitoring (1)
- therapy resistance (1)
- thiazolidine and perhydrothiazine derivatives of aldophosphamide and I-aldophosphamide (1)
- three-stage Markov task (1)
- thrombectomy (1)
- thrombin (1)
- thrombolysis (1)
- thrombolysis (tPA) (1)
- thrombopenia (1)
- thrombopietin receptor agonist (1)
- thrombosis (1)
- thymic selection (1)
- tick (1)
- tissue mechanics (1)
- tobacco control (1)
- tobacco products (1)
- tobacco taxation (1)
- toc64 (1)
- toll-like receptor (1)
- topical agent (1)
- tractography (1)
- traffic emissions (1)
- trafficking (1)
- training program (1)
- transcription factors (1)
- transcriptional profiling (1)
- transcriptome analysis (1)
- transfer entropy (1)
- transferrin (1)
- transient elastography (1)
- transient receptor potential channels (1)
- transjugular intrahepatic portosystemic shunt (TIPS) (1)
- transketolase-like protein 1 (1)
- translational medical research (1)
- translational study (1)
- translocon (1)
- transmission (1)
- transrectal prostate biopsy (1)
- transverse axis (1)
- trauma registry (1)
- traumaticbraininjury(TBI) (1)
- treatment (1)
- triathlon (1)
- trophoblast organoids (1)
- trophoblastic cell lines (1)
- tumor adhesion (1)
- tumor immune evasion (1)
- tumor metabolism (1)
- tumor migration (1)
- tumor pain (1)
- tumor proliferation (1)
- tumor stroma (1)
- tumor-associated macrophages (TAM) (1)
- type B (1)
- type I interferon (1)
- tyrosine hydroxylase (1)
- tyrosine kinase receptor signaling (1)
- ubiquitin ligase (1)
- ulcerative colitis (1)
- ultrasonic cleaning (1)
- ultrasound (1)
- unconventional T cell (1)
- unilateral hip osteoarthritis (1)
- upgrading (1)
- urethal stricture (1)
- urethroplasty (1)
- usability (1)
- ustekinumab (1)
- vaccination (1)
- validity (1)
- valproic acid (1)
- vasoconstriction (1)
- vasodilation (1)
- vemurafenib (1)
- ventilation modes (1)
- ventralis intermedius nucleus (1)
- vertical transmission (1)
- vertigo (1)
- vestibular function (1)
- viability (1)
- viral tracing (1)
- virulence (1)
- virus (1)
- vismodegib (GDC-0449) (1)
- vitamin D deficiency (1)
- vitamin D metabolites (1)
- vitamin D receptor (1)
- vocational (1)
- volatile organic compounds (VOC) (1)
- volatile sedation (1)
- waiting time (1)
- walking (1)
- wheezing (1)
- whole-genome sequencing (1)
- wild animals (1)
- within-person factors (1)
- workplace health promotion (1)
- wound healing (1)
- xenograft (1)
- zinc protoporphyrin (1)
- zirconia (1)
- ß-D-glucan (1)
- ß-amyloid (1)
- β-lactamases (1)
- γδT cell (1)
- fibrogenesis (1)
- fingolimod (1)
- flow cytometry (1)
Institute
Purpose: To assess the diagnostic precision of three different workstations for measuring thoracic aortic aneurysms (TAAs) in vivo and ex vivo using either pre-interventional computed tomography angiography scans (CTA) or a specifically designed phantom model.
Methods: This retrospective study included 23 patients with confirmed TAA on routinely performed CTAs. In addition to phantom tube diameters, one experienced blinded radiologist evaluated the dimensions of TAAs on three different workstations in two separate rounds. Precision was assessed by calculating measurement errors. In addition, correlation analysis was performed using Pearson correlation.
Results: Measurements acquired at the Siemens workstation deviated by 3.54% (range, 2.78–4.03%; p = 0.14) from the true size, those at General Electric by 4.05% (range, 1.46–7.09%; p < 0.0001), and at TeraRecon by 4.86% (range, 3.22–6.45%; p < 0.0001). Accordingly, Siemens provided the most precise workstation at simultaneously most fluctuating values (scattering of 4.46%). TeraRecon had the smallest fluctuation (scattering of 2.83%), but the largest deviation from the true size of the phantom. The workstation from General Electric showed a scattering of 2.94%. The highest overall correlation between the 1st and 2nd rounds was observed with measurements from Siemens (r = 0.898), followed by TeraRecon (r = 0.799), and General Electric (r = 0.703). Repetition of measurements reduced processing times by 40% when using General Electric, by 20% with Siemens, and by 18% with TeraRecon.
Conclusions: In conclusion, all three workstations facilitated precise assessment of dimensions in the majority of cases at simultaneously high reproducibility, ensuring accurate pre-interventional planning of thoracic endovascular aortic repair.
Background: Opsoclonus-myoclonus syndrome (OMS) is a rare, immune-mediated neurological disorder. In adults, the pathogenesis can be idiopathic, post-infectious or paraneoplastic, the latter etiology belonging to the ever-expanding group of defined paraneoplastic neurological syndromes (PNS). In contrast to other phenotypes of PNS, OMS cannot be ascribed to a single pathogenic autoantibody. Here, we report the first detailed case of paraneoplastic, antibody-negative OMS occurring in association with a pancreatic neuroendocrine tumor (pNET).
Case presentation: A 33-year-old female presented with a two-week history of severe ataxia of stance and gait, dysarthria, head tremor, myoclonus of the extremities and opsoclonus. Her past medical history was notable for a metastatic pancreatic neuroendocrine tumor, and she was subsequently diagnosed with paraneoplastic opsoclonus-myoclonus syndrome. Further workup did not reveal a paraneoplastic autoantibody. She responded well to plasmapheresis, as she was refractory to the first-line therapy with corticosteroids.
Conclusions: This case expands current knowledge on tumors associated with paraneoplastic opsoclonus-myoclonus syndrome and the age group in which it can occur. It further adds evidence to the effectiveness of plasmapheresis in severe cases of opsoclonus-myoclonus syndrome with a lack of response to first-line therapy.
Structured management programs have been developed for single diseases but rarely for patients with multiple medications. We conducted a qualitative study to investigate the views of stakeholders on the development and implementation of a polypharmacy management program in Germany. Overall, we interviewed ten experts in the fields of health policy and clinical practice. Using content analysis, we identified inclusion criteria for the selection of suitable patients, the individual elements that should make up such a program, healthcare providers and stakeholders that should be involved, and factors that may support or hinder the program’s implementation. All stakeholders were well aware of polypharmacy-related risks and challenges, as well as the urgent need for change. Intervention strategies should address all levels of care and include all concerned patients, caregivers, healthcare providers and stakeholders, and involved parties should agree on a joint approach.
Zielsetzung: Ziel der Studie ist die Frage, ob es möglich ist, einen Kommunikationskurs für ca. 400 Studierende erfolgreich in ein Blended Learning-Format (asynchrone Theorievermittlung/digitaler synchroner Praxisteil) umzustellen. Hauptfokus war dabei die Beurteilung des subjektiven Lernzuwachses und die Frage, inwiefern die Bedeutung des Themas Kommunikation und Gesprächsführung online abgebildet werden kann. Die Betrachtung erfolgt auf Basis von Evaluationsergebnissen der Studierenden und Dozierenden dieses Kurses.
Methodik: Die Studierenden des vierten vorklinischen Semesters aus dem Jahr 2020 wurden durch einen Selbsteinschätzungsbogen zu Beginn sowie durch eine Evaluation nach Abschluss des Kurses befragt. Zusätzlich wurden die Rückmeldungen der Dozierenden zum Kurs ausgewertet. Um die Ergebnisse vergleichen und mögliche Unterschiede feststellen zu können, wurden die entsprechenden Selbsteinschätzungs- und Evaluationsergebnisse der vorangegangenen zehn Jahre (in Form von Präsenzkursen) herangezogen.
Ergebnisse: Im Onlineformat wurde ein deutlicher subjektiver Lernzuwachs angegeben, der höher ausfiel als in den Vorjahren in Präsenz. Die Eignung des Onlineformats wurde von Studierenden sowie Dozierenden eher kritisch bewertet, während die Kursatmosphäre positiv gesehen wurde. Die Relevanz ärztlicher Gesprächsführung wurde im Onlineformat insgesamt besonders gut bewertet.
Schlussfolgerung: Aufgrund der Evaluationsergebnisse werden die Erfahrungen mit dem Blended Learning-Format auch in Zukunft in das Kommunikations-Curriculum des Medizinstudiums der Goethe-Universität Frankfurt einfließen. Die Ergebnisse haben gezeigt, dass das Erlernen ärztlicher Gesprächsführung online gut möglich ist. Daher kann dieses Format für zukünftige neue Konzepte empfohlen werden.
Objectives: To assess the impact of noise-optimised virtual monoenergetic imaging (VMI+) on image quality and diagnostic evaluation in abdominal dual-energy CT scans with impaired portal-venous contrast.
Methods: We screened 11,746 patients who underwent portal-venous abdominal dual-energy CT for cancer staging between 08/2014 and 11/2019 and identified those with poor portal-venous contrast.
Standard linearly-blended image series and VMI+ image series at 40, 50, and 60 keV were reconstructed. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of abdominal organs and vascular structures were calculated. Image noise, image contrast and overall image quality were rated by three radiologists using 5-point Likert scale.
Results: 452 of 11,746 (4%) exams were poorly opacified. We excluded 190 cases due to incomplete datasets or multiple exams of the same patient with a final study group of 262. Highest CNR values in all abdominal organs (liver, 6.4 ± 3.0; kidney, 17.4 ± 7.5; spleen, 8.0 ± 3.5) and vascular structures (aorta, 16.0 ± 7.3; intrahepatic vein, 11.3 ± 4.7; portal vein, 15.5 ± 6.7) were measured at 40 keV VMI+ with significantly superior values compared to all other series. In subjective analysis, highest image contrast was seen at 40 keV VMI+ (4.8 ± 0.4), whereas overall image quality peaked at 50 keV VMI+ (4.2 ± 0.5) with significantly superior results compared to all other series (p < 0.001).
Conclusions: Image reconstruction using VMI+ algorithm at 50 keV significantly improves image contrast and image quality of originally poorly opacified abdominal CT scans and reduces the number of non-diagnostic scans.
Advances in knowledge: We validated the impact of VMI+ reconstructions in poorly attenuated DECT studies of the abdomen in a big data cohort.
The effect of race/ethnicity on cancer-specific mortality after salvage radical prostatectomy
(2022)
Background: To test the effect of race/ethnicity on cancer-specific mortality (CSM) after salvage radical prostatectomy (SRP).
Material and methods: We relied on the Surveillance, Epidemiology and End Results database (SEER, 2004–2016) to identify SRP patients of all race/ethnicity background. Univariate and multivariate Cox regression models addressed CSM according to race/ethnicity.
Results: Of 426 assessable SRP patients, Caucasians accounted for 299 (69.9%) vs. 68 (15.9%) African-Americans vs. 39 (9.1%) Hispanics vs. 20 (4.7%) Asians. At diagnosis, African-Americans (64 years) were younger than Caucasians (66 years), but not younger than Hispanics (66 years) and Asians (67 years). PSA at diagnosis was significantly higher in African-Americans (13.2 ng/ml), Hispanics (13.0 ng/ml), and Asians (12.2 ng/ml) than in Caucasians (7.8 ng/ml, p = 0.01). Moreover, the distribution of African-Americans (10.3%–36.6%) and Hispanics (0%–15.8%) varied according to SEER region. The 10-year CSM was 46.5% in African-Americans vs. 22.4% in Caucasians vs. 15.4% in Hispanics vs. 15.0% in Asians. After multivariate adjustment (for age, clinical T stage, lymph node dissection status), African-American race/ethnicity was an independent predictor of higher CSM (HR: 2.2, p < 0.01), but not Hispanic or Asian race/ethnicity. The independent effect of African-American race/ethnicity did not persist after further adjustment for PSA.
Conclusion: African-Americans treated with SRP are at higher risk of CSM than other racial/ethnic groups and also exhibited the highest baseline PSA. The independent effect of African-American race/ethnicity on higher CSM no longer applies after PSA adjustment since higher PSA represents a distinguishing feature in African-American patients.
Background: Prostate cancer is a major health concern in aging men. Paralleling an aging society, prostate cancer prevalence increases emphasizing the need for efcient diagnostic algorithms.
Methods: Retrospectively, 106 prostate tissue samples from 48 patients (mean age,
66 ± 6.6 years) were included in the study. Patients sufered from prostate cancer (n = 38) or benign prostatic hyperplasia (n = 10) and were treated with radical prostatectomy or Holmium laser enucleation of the prostate, respectively. We constructed tissue microarrays (TMAs) comprising representative malignant (n = 38) and benign (n = 68) tissue cores. TMAs were processed to histological slides, stained, digitized and assessed for the applicability of machine learning strategies and open–source tools in diagnosis of prostate cancer. We applied the software QuPath to extract features for shape, stain intensity, and texture of TMA cores for three stainings, H&E, ERG, and PIN-4. Three machine learning algorithms, neural network (NN), support vector machines (SVM), and random forest (RF), were trained and cross-validated with 100 Monte Carlo random splits into 70% training set and 30% test set. We determined AUC values for single color channels, with and without optimization of hyperparameters by exhaustive grid search. We applied recursive feature elimination to feature sets of multiple color transforms.
Results: Mean AUC was above 0.80. PIN-4 stainings yielded higher AUC than H&E and
ERG. For PIN-4 with the color transform saturation, NN, RF, and SVM revealed AUC of 0.93 ± 0.04, 0.91 ± 0.06, and 0.92 ± 0.05, respectively. Optimization of hyperparameters improved the AUC only slightly by 0.01. For H&E, feature selection resulted in no increase of AUC but to an increase of 0.02–0.06 for ERG and PIN-4.
Conclusions: Automated pipelines may be able to discriminate with high accuracy between malignant and benign tissue. We found PIN-4 staining best suited for classifcation. Further bioinformatic analysis of larger data sets would be crucial to evaluate the reliability of automated classifcation methods for clinical practice and to evaluate potential discrimination of aggressiveness of cancer to pave the way to automatic precision medicine.
This prospective study sought to evaluate potential savings of radiation dose to medical staff using real-time dosimetry coupled with visual radiation dose feedback during angiographic interventions. For this purpose, we analyzed a total of 214 angiographic examinations that consisted of chemoembolizations and several other types of therapeutic interventions. The Unfors RaySafe i2 dosimeter was worn by the interventionalist at chest height over the lead protection. A total of 110 interventions were performed with real-time radiation dosimetry allowing the interventionalist to react upon higher x-ray exposure and 104 examinations served as the comparative group without real-time radiation monitoring. By using the real-time display during interventions, the overall mean operator radiation dose decreased from 3.67 (IQR, 0.95–23.01) to 2.36 μSv (IQR, 0.52–12.66) (−36%; p = 0.032) at simultaneously reduced operator exposure time by 4.5 min (p = 0.071). Dividing interventions into chemoembolizations and other types of therapeutic interventions, radiation dose decreased from 1.31 (IQR, 0.46-3.62) to 0.95 μSv (IQR, 0.53-3.11) and from 24.39 (IQR, 12.14-63.0) to 10.37 μSv (IQR, 0.85-36.84), respectively, using live-screen dosimetry (p ≤ 0.005). Radiation dose reductions were also observed for the participating assistants, indicating that they could also benefit from real-time visual feedback dosimetry during interventions (−30%; p = 0.039). Integration of real-time dosimetry into clinical processes might be useful in reducing occupational radiation exposure time during angiographic interventions. The real-time visual feedback raised the awareness of interventionalists and their assistants to the potential danger of prolonged radiation exposure leading to the adoption of radiation-sparing practices. Therefore, it might create a safer environment for the medical staff by keeping the applied radiation exposure as low as possible.
The combination of histological and biomolecular analyses provides deep understanding of different biological processes and is of high interest for basic and applied research. However, the available analytical methods are still limited, especially when considering bone samples. This study compared different fixation media to identify a sufficient analytical method for the combination of histological, immuno-histological and biomolecular analyses of the same fixed, processed and paraffin embedded bone sample. Bone core biopsies of rats’ femurs were fixed in different media (RNAlater + formaldehyde (R + FFPE), methacarn (MFPE) or formaldehyde (FFPE)) for 1 week prior to decalcification by EDTA and further histological processing and paraffin embedding. Snap freezing (unfixed frozen tissue, UFT) and incubation in RNAlater were used as additional controls. After gaining the paraffin sections for histological and immunohistological analysis, the samples were deparaffined and RNA was isolated by a modified TRIZOL protocol. Subsequently, gene expression was evaluated using RT-qPCR. Comparable histo-morphological and immuno-histological results were evident in all paraffin embedded samples of MFPE, FFPE and R + FFPE. The isolated RNA in the group of MFPE showed a high concentration and high purity, which was comparable to the UFT and RNAlater groups. However, in the groups of FFPE and R + FFPE, the RNA quality and quantity were statistically significantly lower when compared to MFPE, UFT and RNAlater. RT-qPCR results showed a comparable outcome in the group of MFPE and UFT, whereas the groups of FFPE and R + FFPE did not result in a correctly amplified gene product. Sample fixation by means of methacarn is of high interest for clinical samples to allow a combination of histological, immunohistological and biomolecular analysis. The implementation of such evaluation method in clinical research may allow a deeper understanding of the processes of bone formation and regeneration.