610 Medizin und Gesundheit
Refine
Year of publication
Document Type
- Article (6056)
- Doctoral Thesis (1973)
- Preprint (281)
- Part of Periodical (244)
- Conference Proceeding (203)
- Book (175)
- Contribution to a Periodical (171)
- Review (58)
- Part of a Book (39)
- Working Paper (17)
Language
- English (6174)
- German (3006)
- Latin (26)
- mis (13)
- Multiple languages (13)
- French (11)
- Portuguese (1)
- Romanian (1)
- Russian (1)
- Spanish (1)
Has Fulltext
- yes (9248) (remove)
Keywords
- inflammation (95)
- COVID-19 (68)
- SARS-CoV-2 (54)
- apoptosis (41)
- cancer (41)
- Inflammation (40)
- glioblastoma (38)
- breast cancer (34)
- autophagy (32)
- Cancer (30)
- prostate cancer (29)
- Depression (27)
- Apoptosis (26)
- ADHD (25)
- aging (25)
- biomarker (25)
- pain (25)
- wassergefiltertes Infrarot A (wIRA) (25)
- Epilepsy (24)
- macrophage (24)
- quality of life (24)
- immunotherapy (23)
- Quality of life (22)
- Wundheilung (22)
- Germany (21)
- Gewebetemperatur (21)
- Video (21)
- children (21)
- microRNA (21)
- Gewebedurchblutung (20)
- HIV (20)
- chemotherapy (20)
- mitochondria (20)
- reactive oxygen species (20)
- Biomarker (19)
- EEG (19)
- MRI (19)
- Sauerstoffpartialdruck im Gewebe (19)
- Schmerzminderung (19)
- Stroke (19)
- data science (19)
- depression (19)
- epilepsy (19)
- hypoxia (19)
- Breast cancer (18)
- Schmerz (18)
- fMRI (18)
- prevention (18)
- water-filtered infrared-A (wIRA) (18)
- Human behaviour (17)
- Neuroscience (17)
- Treatment (17)
- glioma (17)
- tumor microenvironment (17)
- Entzündung (16)
- Infektionsabwehr (16)
- Lebensqualität (16)
- Machine learning (16)
- Medizin (16)
- Outcome (16)
- Prävention (16)
- Surgery (16)
- angiogenesis (16)
- cognition (16)
- endothelial cells (16)
- mTOR (16)
- proliferation (16)
- stroke (16)
- treatment (16)
- Cirrhosis (15)
- Genetics (15)
- lung cancer (15)
- multiple sclerosis (15)
- radical prostatectomy (15)
- reduction of pain (15)
- tissue oxygen partial pressure (15)
- tissue temperature (15)
- Angiogenesis (14)
- Cell biology (14)
- Infrarot (14)
- Magnetic resonance imaging (14)
- Mitochondria (14)
- Parkinson’s disease (14)
- Radiotherapy (14)
- Sauerstoffversorgung (14)
- cytokines (14)
- diagnosis (14)
- epigenetics (14)
- mortality (14)
- obesity (14)
- schizophrenia (14)
- tissue blood flow (14)
- wound healing (14)
- Biomarkers (13)
- Capsule endoscopy (13)
- Diagnostik (13)
- Gene expression (13)
- Immunotherapy (13)
- Mammakarzinom (13)
- Mortality (13)
- NADPH oxidase (13)
- Oncology (13)
- attention (13)
- bladder cancer (13)
- cirrhosis (13)
- coronavirus (13)
- epidemiology (13)
- macrophages (13)
- miRNA (13)
- neurodegeneration (13)
- proteomics (13)
- Epidemiology (12)
- HCV (12)
- Immunology (12)
- Mosambik (12)
- Mozambique (12)
- Moçambique (12)
- ROS (12)
- Sepsis (12)
- cell death (12)
- child (12)
- colorectal cancer (12)
- extracellular matrix (12)
- leukemia (12)
- machine learning (12)
- oxidative stress (12)
- prevalence (12)
- surgery (12)
- survival (12)
- targeted therapy (12)
- Chemotherapy (11)
- Endoscopy (11)
- Heart failure (11)
- PCR (11)
- Primary care (11)
- Prostate cancer (11)
- Seizure (11)
- Suicide (11)
- exercise (11)
- hippocampus (11)
- integrins (11)
- invasion (11)
- macrophage polarization (11)
- magnetic resonance imaging (11)
- outcome (11)
- psoriasis (11)
- radiotherapy (11)
- trauma (11)
- ACLF (10)
- COPD (10)
- Diabetes mellitus (10)
- Diagnostic markers (10)
- Endothelial cells (10)
- Hepatocellular carcinoma (10)
- Krankheit (10)
- Macrophages (10)
- Pain (10)
- Research article (10)
- Small bowel (10)
- Survival (10)
- Trauma (10)
- artificial intelligence (10)
- atherosclerosis (10)
- curcumin (10)
- elderly (10)
- gene therapy (10)
- hepatitis C virus (10)
- infection (10)
- innate immunity (10)
- liver (10)
- metabolism (10)
- migration (10)
- neuroblastoma (10)
- neuropathic pain (10)
- osteoarthritis (10)
- p53 (10)
- physical activity (10)
- risk factors (10)
- therapy (10)
- Alzheimer’s disease (9)
- Atrial fibrillation (9)
- Bipolar disorder (9)
- Blood (9)
- Children (9)
- Diagnosis (9)
- Drug therapy (9)
- EGFR (9)
- Energieumsatz <Medizin> (9)
- General practice (9)
- Hemorrhage (9)
- Hepatitis C (9)
- Malaria (9)
- Medizinische Ausbildung (9)
- Metastasen (9)
- Molecular biology (9)
- Multimorbidity (9)
- NASH (9)
- Proteomics (9)
- Schizophrenia (9)
- VEGF (9)
- Wunde (9)
- adhesion (9)
- adolescents (9)
- brain metastases (9)
- complications (9)
- differentiation (9)
- drug resistance (9)
- hepatocellular carcinoma (9)
- hereditary angioedema (9)
- human (9)
- metastasis (9)
- portal hypertension (9)
- sepsis (9)
- vaccination (9)
- AML (8)
- Acute myeloid leukemia (8)
- Aging (8)
- Autophagy (8)
- Autopsy (8)
- Behandlung (8)
- Cardiovascular magnetic resonance (8)
- DNA methylation (8)
- Diagnostics (8)
- Energiebereitstellung (8)
- Epilepsie (8)
- Europe (8)
- Evaluation (8)
- Gender (8)
- Geschichte (8)
- HIV-1 (8)
- Hepatitis C virus (8)
- Hypertension (8)
- In vitro (8)
- Kongress (8)
- Liver diseases (8)
- Medical research (8)
- Prevention (8)
- Problemwunden (8)
- Prognosis (8)
- RNA (8)
- Rare diseases (8)
- TAVI (8)
- Wundinfektion (8)
- Wundinfektionen (8)
- Wundsekretion (8)
- aortic stenosis (8)
- chronic kidney disease (8)
- development (8)
- energy supply (8)
- exosomes (8)
- fibrosis (8)
- gender (8)
- heart failure (8)
- liver transplantation (8)
- medical education (8)
- microglia (8)
- monocytes (8)
- mouse (8)
- oxygen supply (8)
- periodontitis (8)
- polytrauma (8)
- primary care (8)
- problem wounds (8)
- renal cell carcinoma (8)
- sphingosine-1-phosphate (8)
- transcranial magnetic stimulation (8)
- wound infections (8)
- AIDS (7)
- Autism spectrum disorder (7)
- Borrelia (7)
- Brustkrebs (7)
- Cancer treatment (7)
- Colorectal cancer (7)
- Deutschland (7)
- Exercise (7)
- Forensic entomology (7)
- HCC (7)
- HDAC (7)
- Heart (7)
- Herb induced liver injury (7)
- Hypoxia (7)
- Immunohistochemistry (7)
- Immunological methods (7)
- Immunologische Methoden (7)
- Kardiovaskuläre Krankheit (7)
- MEG (7)
- Mechanisms of disease (7)
- Mental health and psychiatry (7)
- Multiple sclerosis (7)
- NK cells (7)
- Neurology (7)
- Obesity (7)
- Osteoporosis (7)
- PD-L1 (7)
- Pandemic (7)
- Patients (7)
- Polytrauma (7)
- Postural control (7)
- Prevalence (7)
- Risk factors (7)
- Sekretion (7)
- TRAIL (7)
- Therapie (7)
- Training (7)
- Transfusion (7)
- antiviral therapy (7)
- asthma (7)
- biomarkers (7)
- bipolar disorder (7)
- cholesterol (7)
- cochlear implant (7)
- conduct disorder (7)
- diffusion tensor imaging (7)
- efficacy (7)
- gene expression (7)
- hematopoietic stem cell transplantation (7)
- iron (7)
- liver cirrhosis (7)
- machine-learning (7)
- medical students (7)
- metastases (7)
- microbiome (7)
- natural killer cells (7)
- particulate matter (7)
- polypharmacy (7)
- pregnancy (7)
- prognosis (7)
- prophylaxis (7)
- resistance (7)
- seizure (7)
- signal transduction (7)
- sphingolipids (7)
- thermal and non-thermal effects (7)
- thermische und nicht-thermische Effekte (7)
- thrombosis (7)
- toxicity (7)
- tumor-associated macrophages (7)
- ubiquitin (7)
- working memory (7)
- wound exudation (7)
- ATM (6)
- Adenocarcinoma (6)
- Allgemeinmedizin (6)
- Antiviral therapy (6)
- Atherosclerosis (6)
- Attention (6)
- Balloon enteroscopy (6)
- CDK4/6 (6)
- CRISPR/Cas9 (6)
- Cell signalling (6)
- Clinical trial (6)
- Cognition (6)
- Comorbidity (6)
- Complications (6)
- Crohn’s disease (6)
- DMEK (6)
- Data science (6)
- Death rates (6)
- Dopamine (6)
- Elderly (6)
- Electroencephalography (6)
- Enteroscopy (6)
- Extracellular matrix (6)
- Gene regulation (6)
- Gesundheit (6)
- Gesundheitserziehung (6)
- Glioblastoma (6)
- Goethe-Universität Frankfurt am Main. Fachbereich Humanmedizin (6)
- HBV (6)
- Health economics (6)
- Hippocampus (6)
- Immunsuppression (6)
- Incidence (6)
- Kommunikation (6)
- Liver transplantation (6)
- Medical education (6)
- Medizin und Gesundheit (6)
- Medizinstudium (6)
- Molecular neuroscience (6)
- Morbidity (6)
- Multivariate analysis (6)
- Non-small cell lung cancer (6)
- OSCE (6)
- Oral anticoagulation (6)
- Outcomes (6)
- PD1/PDL1 (6)
- PI3K (6)
- Parkinson's disease (6)
- Patient blood management (6)
- Physical activity (6)
- Pneumonia (6)
- Portal hypertension (6)
- Pregnancy (6)
- Psychiatric disorders (6)
- Radiomics (6)
- Randomized controlled trial (6)
- Reactive oxygen species (6)
- Rectal cancer (6)
- Regeneration (6)
- Registry (6)
- Rheumatoid arthritis (6)
- Status epilepticus (6)
- Studien (6)
- Surgical and invasive medical procedures (6)
- T cell (6)
- T cells (6)
- Targeted therapy (6)
- Translational research (6)
- Ultrasound (6)
- Viral load (6)
- Vitamin D (6)
- X-ray crystallography (6)
- acute lymphoblastic leukemia (6)
- acute myeloid leukemia (6)
- acute wounds (6)
- acute-on-chronic liver failure (6)
- akute Wunden (6)
- anemia (6)
- atrial fibrillation (6)
- bevacizumab (6)
- chronische venöse Unterschenkel-Ulzera (6)
- clinical trial (6)
- colon cancer (6)
- cytotoxicity (6)
- dentate gyrus (6)
- diabetes (6)
- disease (6)
- environmental tobacco smoke (6)
- fibroblasts (6)
- flow cytometry (6)
- growth (6)
- guideline (6)
- guidelines (6)
- health education (6)
- imaging (6)
- immunity (6)
- immunohistochemistry (6)
- infection defense (6)
- influenza (6)
- information theory (6)
- integrin (6)
- iron deficiency (6)
- lactate (6)
- liver fibrosis (6)
- mass spectrometry (6)
- mathematical modeling (6)
- medizinische Ausbildung (6)
- melanoma (6)
- memory (6)
- mesenchymal stromal/stem cells (6)
- metabolomics (6)
- mice (6)
- multimorbidity (6)
- nitric oxide (6)
- ovarian cancer (6)
- overall survival (6)
- plasticity (6)
- predictive coding (6)
- qualitative research (6)
- radiation (6)
- rhabdomyosarcoma (6)
- safety (6)
- sphingosine 1-phosphate (6)
- stress (6)
- synaptic plasticity (6)
- systematic review (6)
- temperaturabhängige und temperaturunabhängige Effekte (6)
- thermic and non-thermic effects (6)
- ultrasound (6)
- vaccine (6)
- visuelle Analogskalen (VAS) (6)
- vitamin D (6)
- ARDS (5)
- Allergie (5)
- Alzheimer's disease (5)
- Anticoagulation (5)
- Aortic stenosis (5)
- Arteriosklerose (5)
- Artificial intelligence (5)
- Aspergillus (5)
- Ataxia telangiectasia (5)
- Attitude (5)
- Autism (5)
- B cells (5)
- BMC (5)
- BRD4 (5)
- Biochemistry (5)
- Brain (5)
- C-reactive protein (5)
- Calliphoridae (5)
- Candida (5)
- Cardiovascular disease (5)
- Cardiovascular diseases (5)
- Cell staining (5)
- Cell therapy (5)
- Clinical trials (5)
- Consensus (5)
- Critical care (5)
- Cytokines (5)
- DAA (5)
- Decision making (5)
- Diabetes (5)
- Diagnose (5)
- Diseases (5)
- Drug induced liver injury (5)
- ELISA (5)
- Education (5)
- Emotions (5)
- Epigenetics (5)
- Everolimus (5)
- Ewing sarcoma (5)
- Experimental models of disease (5)
- Extracellular vesicles (5)
- Eye movements (5)
- GPCR (5)
- Gastric cancer (5)
- Glioma (5)
- Guidelines (5)
- HNSCC (5)
- Health care (5)
- Hepatitis (5)
- Hepatotoxicity (5)
- Herbal hepatotoxicity (5)
- Histology (5)
- Hodgkin lymphoma (5)
- Hyperthermie (5)
- IL-6 (5)
- Immunsystem (5)
- Infection (5)
- Kind (5)
- Kinematic analysis (5)
- Legs (5)
- Lymphozyt (5)
- MLL (5)
- MRT (5)
- Machine-learning (5)
- Melanoma (5)
- MicroRNAs (5)
- Migration (5)
- Mitochondrial dysfunction (5)
- Molecular medicine (5)
- Mouse models (5)
- Musculoskeletal system (5)
- NF-κB (5)
- NK cell (5)
- NK-92 (5)
- NKG2D (5)
- NMR-Tomographie (5)
- NO (5)
- NS5A (5)
- Neurons (5)
- Nitric oxide (5)
- Omicron (5)
- PTSD (5)
- Personalized medicine (5)
- Pharmacology (5)
- Platelet-rich fibrin (5)
- Polypharmacy (5)
- Posttraumatic stress disorder (5)
- Prediction (5)
- Predictive markers (5)
- Proliferation (5)
- Psychology (5)
- Quelle (5)
- RUCAM (5)
- Reaction time (5)
- Rhabdomyosarcoma (5)
- Risiko (5)
- STAT3 (5)
- Safety (5)
- Schlaganfall (5)
- Screening (5)
- Signaling (5)
- Smac (5)
- Sportmedizin (5)
- Surgical oncology (5)
- Treatment outcome (5)
- Tumor microenvironment (5)
- Vaccination (5)
- Validation (5)
- Vision (5)
- acute coronary syndrome (5)
- adaptation (5)
- age (5)
- ataxia telangiectasia (5)
- auditory cortex (5)
- cardiac surgery (5)
- cardiovascular disease (5)
- cell therapy (5)
- ceramides (5)
- cervical cancer (5)
- chimeric antigen receptor (5)
- chronic venous stasis ulcers of the lower legs (5)
- complement (5)
- confinement (5)
- connective tissue (5)
- critical care (5)
- dendritic cells (5)
- dental implants (5)
- diabetes mellitus (5)
- digital medicine (5)
- drug discovery (5)
- evaluation (5)
- everolimus (5)
- extracellular vesicles (5)
- functional magnetic resonance imaging (5)
- graph theory (5)
- histology (5)
- hyperglycemia (5)
- immune response (5)
- impulsivity (5)
- lipocalin-2 (5)
- lncRNA (5)
- long non-coding RNA (5)
- meningioma (5)
- natural killer cell (5)
- outcomes (5)
- pancreatic cancer (5)
- pandemic (5)
- patient blood management (5)
- patient safety (5)
- patients (5)
- perception (5)
- phagocytosis (5)
- phosphorylation (5)
- platelets (5)
- precision medicine (5)
- preeclampsia (5)
- prospective, randomized, controlled, double-blind studies (5)
- prospektive, randomisierte, kontrollierte, doppeltblinde Studien (5)
- prostaglandins (5)
- protein degradation (5)
- psychotherapy (5)
- public health (5)
- quantitative MRI (5)
- rapamycin (5)
- rat (5)
- regeneration (5)
- rheumatoid arthritis (5)
- screening (5)
- sleep (5)
- sulforaphane (5)
- tissue engineering (5)
- ubiquitination (5)
- valproic acid (5)
- vector (5)
- visual cortex (5)
- 177Lu-PSMA-617 (4)
- 3D printing (4)
- 5-lipoxygenase (4)
- ABCB1 (4)
- Acute inflammation (4)
- Acute lymphoblastic leukemia (4)
- Adherence (4)
- Adhesion (4)
- Age groups (4)
- Alcohol (4)
- Alzheimer (4)
- Amblyopia (4)
- Anemia (4)
- Angiography (4)
- Animal models (4)
- Antikörper (4)
- Aortic valve (4)
- Ascites (4)
- Aspergillus fumigatus (4)
- B-cell lymphoma (4)
- BCR/ABL (4)
- BRAF (4)
- Bacterial infection (4)
- Behavior (4)
- Biopsy (4)
- Bladder cancer (4)
- Blood pressure (4)
- Bone marrow (4)
- Brain metastasis (4)
- C. elegans (4)
- CIK cells (4)
- CRP (4)
- CT (4)
- CXCR4 (4)
- Cannabis (4)
- Cardiology (4)
- Cell proliferation (4)
- Cerebellum (4)
- Cesarean section (4)
- Chemoradiotherapy (4)
- Chronic kidney disease (4)
- Classification (4)
- Cognitive behavioral therapy (4)
- Cognitive impairment (4)
- Cohort studies (4)
- Communication (4)
- Complex I (4)
- Computational models (4)
- Corona (4)
- DILI (4)
- DNA damage (4)
- DTI (4)
- Data processing (4)
- Dementia (4)
- Denosumab (4)
- Density equalizing mapping (4)
- Developmental biology (4)
- Diagnostic medicine (4)
- Dravet syndrome (4)
- ER stress (4)
- Emotion regulation (4)
- Endoscopic retrograde cholangiopancreatography (4)
- Endothelium (4)
- Epileptischer Anfall (4)
- European Union (4)
- Evidence-based medicine (4)
- Eyes (4)
- Flow cytometry (4)
- Functional connectivity (4)
- Functional magnetic resonance imaging (4)
- Genetics research (4)
- Geschlecht (4)
- Gesundheitsökonomie (4)
- Glioblastom (4)
- Glucose (4)
- HAE (4)
- Healthcare worker (4)
- Heart transplantation (4)
- Hematology (4)
- Hepatitis B (4)
- Hereditary angioedema (4)
- Homeostasis (4)
- IAP proteins (4)
- Ibo <Moçambique> (4)
- Immunologie (4)
- Infections (4)
- Infrarot-Thermographie (4)
- IntelliCage (4)
- Intensive care (4)
- Intensive care units (4)
- Interleukin (4)
- Interleukin-6 (4)
- Ischemia (4)
- Knees (4)
- Labor and delivery (4)
- Lehrbuch (4)
- Lesenlernen (4)
- Liver cirrhosis (4)
- Liver fibrosis (4)
- Long non-coding RNAs (4)
- Lung failure (4)
- MRSA (4)
- MSD (4)
- MYC (4)
- Mass spectrometry (4)
- Medical risk factors (4)
- Medizindidaktik (4)
- Medizingeschichte (4)
- Medizinstudenten (4)
- Medizinstudierende (4)
- Microbiology (4)
- Mouse (4)
- Musculoskeletal diseases (4)
- Mwani (4)
- Mwani <Sprache> (4)
- Myocardial infarction (4)
- NAFLD (4)
- Neonates (4)
- Neural networks (4)
- Neurochirurgie (4)
- Neutropenia (4)
- Next-generation sequencing (4)
- Nierentransplantation (4)
- Nox4 (4)
- NoxO1 (4)
- Nrf2 (4)
- Older adults (4)
- PSMA (4)
- Pandemie (4)
- Pathogenesis (4)
- Patient safety (4)
- Pediatric (4)
- Phagocytosis (4)
- Physicians (4)
- Physiology (4)
- Plasticity (4)
- Preclinical research (4)
- Preventive medicine (4)
- Prophylaxis (4)
- Prostatakarzinom (4)
- Public health (4)
- Pulmonary embolism (4)
- Quality of care (4)
- Quantitative MRI (4)
- Register (4)
- Registries (4)
- Rehabilitation (4)
- Resistenz (4)
- Roussel Uclaf Causality Assessment Method (4)
- Seltene Erkrankungen (4)
- Sensitivity (4)
- Sensitivity and Specificity (4)
- Sensory perception (4)
- Sex (4)
- Sex differences (4)
- Speech (4)
- Sport (4)
- Stem cell (4)
- Stem cells (4)
- Suicidality (4)
- Surveillance (4)
- Systematic review (4)
- TACE (4)
- Tacrolimus (4)
- Therapy (4)
- Thrombose (4)
- Thrombosis (4)
- Tiermodell (4)
- Tissue engineering (4)
- Transcription factors (4)
- Tumormarker (4)
- Ubiquitination (4)
- Ultraschall (4)
- Wound healing (4)
- XIAP (4)
- Zika virus (4)
- acetaminophen (4)
- acute kidney injury (4)
- adjuvant therapy (4)
- adjuvante Therapie (4)
- adverse events (4)
- aggression (4)
- alcohol (4)
- alirocumab (4)
- anaemia (4)
- animal (4)
- antibodies (4)
- antioxidants (4)
- augmentation (4)
- bibliometrics (4)
- bibliometry (4)
- bioinformatics (4)
- brachytherapy (4)
- breast (4)
- cGMP (4)
- cancer stem cells (4)
- cell biology (4)
- cell migration (4)
- cerebellum (4)
- cerebrospinal fluid (4)
- chemoradiotherapy (4)
- chemoresistance (4)
- classical Hodgkin lymphoma (4)
- classification (4)
- climate change (4)
- clinical study (4)
- co-infection (4)
- collagen (4)
- combination therapy (4)
- complication (4)
- computed tomography (4)
- connectivity (4)
- contact-free method (4)
- cortex (4)
- cystic fibrosis (4)
- cytomegalovirus (4)
- dementia (4)
- dendrite (4)
- dental implant (4)
- dentist (4)
- diagnostics (4)
- direct-acting antivirals (4)
- dopamine (4)
- doxorubicin (4)
- early breast cancer (4)
- electroencephalography (4)
- electrolytic cleaning (4)
- electrophysiology (4)
- entropy (4)
- epigenetic (4)
- ergonomics (4)
- executive function (4)
- external beam radiotherapy (4)
- faculty development (4)
- fatigue (4)
- forensic entomology (4)
- frühes Mammakarzinom (4)
- functional connectivity (4)
- gastric cancer (4)
- general practice (4)
- glycolysis (4)
- haemophilia treatment (4)
- health-related quality of life (4)
- hemorrhage (4)
- hepatitis C (4)
- hepatitis C virus (HCV) (4)
- immune evasion (4)
- immune system (4)
- immunology (4)
- in vitro (4)
- inflammasome (4)
- inflammatory bowel disease (4)
- infrared thermography (4)
- kidney (4)
- kontaktfreies, verbrauchsmaterialfreies Verfahren (4)
- learning to read (4)
- leukocytes (4)
- levetiracetam (4)
- lipid metabolism (4)
- lipoxygenase (4)
- lung function (4)
- mTORC1 (4)
- management (4)
- mesenchymal stromal cells (4)
- metabolic syndrome (4)
- metastatic prostate cancer (4)
- mitosis (4)
- modeling (4)
- motility (4)
- motor cortex (4)
- multiple myeloma (4)
- musculoskeletal disorders (4)
- mutual information (4)
- neoadjuvant therapy (4)
- neural oscillations (4)
- neurocognition (4)
- neuroimaging (4)
- nociception (4)
- observational study (4)
- oscillations (4)
- p21 (4)
- pediatric (4)
- periimplantitis (4)
- peripheral artery disease (4)
- pharmacokinetics (4)
- polypharmacology (4)
- prefrontal cortex (4)
- primary cilium (4)
- primary health care (4)
- primary immunodeficiency (4)
- primary visual cortex (4)
- prostaglandin (4)
- proteasome (4)
- psoriatic arthritis (4)
- questionnaire (4)
- receptor (4)
- registry (4)
- reliability (4)
- resting state (4)
- resveratrol (4)
- risk (4)
- senescence (4)
- signaling (4)
- simulation training (4)
- skeletal muscle (4)
- smoking (4)
- spinal cord (4)
- spirochetes (4)
- status epilepticus (4)
- stem cell transplantation (4)
- strength training (4)
- temozolomide (4)
- temporal lobe epilepsy (4)
- text book (4)
- thermographic image analysis (4)
- thermographische Bildanalyse (4)
- thrombolysis (4)
- thymus (4)
- tooth loss (4)
- transcription factor (4)
- transfusion (4)
- transplantation (4)
- traumatic brain injury (4)
- treatment centres (4)
- trials (4)
- tumor growth (4)
- tumor progression (4)
- tyrosine kinase inhibitors (4)
- walking (4)
- weight reduction (4)
- (surface) partial differential equations (3)
- 3D rapid prototyping (3)
- ABC Transporter (3)
- ADAM15 (3)
- ADHS (3)
- ALL (3)
- ATP (3)
- Abdominal aortic aneurysm (3)
- Acute kidney injury (3)
- Adolescents (3)
- Adults (3)
- Adverse events (3)
- Antibiotics (3)
- Antibodies (3)
- Antigen Processing (3)
- Antiretroviral therapy (3)
- Anxiety (3)
- Anämie (3)
- Aortic valve replacement (3)
- Arbeitsgedächtnis (3)
- Ataxia-telangiectasia (3)
- Autismus (3)
- BAG3 (3)
- BDNF (3)
- BMI (3)
- Batten disease (3)
- Begriffsgeschichte <Fach> (3)
- Bibliometrics (3)
- Biographie (3)
- Biophysics (3)
- Blood-brain barrier (3)
- Bone defect (3)
- Bone regeneration (3)
- Bone tissue engineering (3)
- Borrelia burgdorferi (3)
- Brain tumor (3)
- Bronchialasthma (3)
- Burden of illness (3)
- C1 inhibitor (3)
- CAD/CAM (3)
- CAR (3)
- CD19 (3)
- CD36 (3)
- COMP (3)
- COVID 19 (3)
- CRM (3)
- CTGF (3)
- CXCL12 (3)
- CXCR3 (3)
- Calcium (3)
- Cancer chemotherapy (3)
- Cancer detection and diagnosis (3)
- Cancer genetics (3)
- Cancer genomics (3)
- Cancer models (3)
- Cardiac surgery (3)
- Carotis (3)
- Case report (3)
- Catheter ablation (3)
- Cell culture (3)
- Cerebrospinal fluid (3)
- Chaperone (3)
- Chemical biology (3)
- Child (3)
- Cholesterin (3)
- Chromatin accessibility (3)
- Chronic diseases (3)
- Chronic hepatitis C (3)
- Ciclosporin (3)
- Citation analysis (3)
- Clinical Trials and Observations (3)
- Clinical competence (3)
- Clinical decision support systems (3)
- Clinical genetics (3)
- Cochlear implant (3)
- Cochlear implantation (3)
- Cognitive neuroscience (3)
- Collagen (3)
- Comorbidities (3)
- Complex II (3)
- Compliance (3)
- Computer software (3)
- Computer-assisted diagnosis (3)
- Conduct disorder (3)
- Connective tissue (3)
- Coping (3)
- Coronary heart disease (3)
- Coronavirus (3)
- Costs (3)
- Covid-19 (3)
- Cryoelectron microscopy (3)
- Crystal structure (3)
- Cystic fibrosis (3)
- Cytokine (3)
- Cytoskeleton (3)
- D-wave (3)
- DNA damage response (3)
- DNA mismatch repair (3)
- DNase1-seq (3)
- Decision (3)
- Decorin (3)
- Deep brain stimulation (3)
- Delegation (3)
- Dental implant (3)
- Dental students (3)
- Dentistry (3)
- Development (3)
- Digitalisierung (3)
- Dose response (3)
- Drug hepatotoxicity (3)
- Drug resistance (3)
- Drugs (3)
- E-Learning (3)
- ECMO (3)
- EEG microstates (3)
- Eccentric fixation (3)
- Edema (3)
- Efficiency (3)
- Ejection fraction (3)
- Emergency room (3)
- Encephalopathy (3)
- Endocrinology (3)
- Endovascular repair (3)
- Entscheidungsassistenz (3)
- Epigenetik (3)
- Epileptische Anfälle (3)
- Evidence based medicine (3)
- Exosomes (3)
- FFLU (3)
- FGFR (3)
- FTY720 (3)
- Fasting (3)
- Feasibility (3)
- Feedback (3)
- Fibronectin (3)
- Fibrosis (3)
- Fingolimod (3)
- Finite Volumes (3)
- Fistula (3)
- Forensic medicine (3)
- Fourier analysis (3)
- Freud, Sigmund (3)
- Frühgeburt (3)
- Functional clustering (3)
- G-CSF (3)
- Gait analysis (3)
- Gene Regulation (3)
- Gene fusion (3)
- Gene therapy (3)
- Genome-wide association studies (3)
- Gesundheitsförderung (3)
- Gesundheitspolitik (3)
- Gesundheitswesen (3)
- Gewichtsabnahme (3)
- Global health (3)
- Goldstein, Kurt (3)
- H1N1 (3)
- HER2 (3)
- HER2/neu (3)
- HIF (3)
- HPV (3)
- HSCT (3)
- Head and neck cancer (3)
- Health services research (3)
- Healthcare costs (3)
- Healthy adults (3)
- HepG2 (3)
- Hepatitis-C-Virus (3)
- Hirnforschung (3)
- HoLEP (3)
- Homosexualität (3)
- Hospitals (3)
- Human genetics (3)
- Hämodynamik (3)
- I-wave (3)
- IBD (3)
- ICD (3)
- ICU (3)
- IFT (3)
- IL-1β (3)
- Image processing (3)
- Immunchemie (3)
- Immune cells (3)
- Immunosuppression (3)
- Impfstoff (3)
- Impfung (3)
- Induction chemotherapy (3)
- Infectious diseases (3)
- Inflammatory bowel disease (3)
- Inflammatory diseases (3)
- Influenza (3)
- Infrarot-A-Strahlung (3)
- Injury (3)
- Innate immunity (3)
- Insulin (3)
- Interleukin-22 (3)
- Ixodes ricinus (3)
- Jaw (3)
- Kidney transplantation (3)
- Kinder (3)
- Kinderheilkunde (3)
- Kinderwunsch (3)
- Knochenersatzmaterial (3)
- Knowledge (3)
- Kolonkarzinom (3)
- Körper (3)
- Körperliche Aktivität (3)
- LCMV (3)
- Langerhans cell histiocytosis (3)
- Language (3)
- Leberzirrhose (3)
- Lehre (3)
- Lehrqualifikation (3)
- Leitlinien (3)
- Lesions (3)
- Leukemia (3)
- Leukozyt (3)
- Leukämie (3)
- Linear regression analysis (3)
- Liver Transplantation (3)
- LncRNA (3)
- Long-term care (3)
- Low back pain (3)
- Lumbar spine (3)
- MCAK (3)
- MCAO (3)
- Macrophage polarization (3)
- Major depressive disorder (3)
- Manner of death (3)
- Masquelet technique (3)
- Membrane proteins (3)
- Mental health (3)
- Mesenchymal stem cells (3)
- Messenger RNA (3)
- Meta-analysis (3)
- Metaanalysis (3)
- Metabolic diseases (3)
- Metabolic syndrome (3)
- Metabolism (3)
- Metabolomics (3)
- Methicillin-resistant Staphylococcus aureus (3)
- Microbiome (3)
- Microwave ablation (3)
- Monitoring (3)
- Morphogenesis (3)
- Morphology (3)
- Motor control (3)
- Multianalyte detection (3)
- Multidetector computed tomography (3)
- Multiplate (3)
- Musculoskeletal disorder (3)
- Myalgia (3)
- NADH dehydrogenase (3)
- NIRS (3)
- NMR spectroscopy (3)
- NSCLC (3)
- Nerve fibers (3)
- Neuroblastom (3)
- Neurodegeneration (3)
- Neuroinflammation (3)
- Nivolumab (3)
- Non-REM sleep (3)
- Nox (3)
- OSPE (3)
- OXA-48 (3)
- Obduktion (3)
- Observational study (3)
- Occlusion treatment (3)
- Occupational health (3)
- Offene Versorgung (3)
- Open repair (3)
- Optogenetics (3)
- Oxidative phosphorylation (3)
- Oxidativer Stress (3)
- PARK2 (3)
- PBPK (3)
- PDGFRβ (3)
- PSA (3)
- Pediatric patients (3)
- Pediatrics (3)
- Penile carcinomas (3)
- Peri-implantitis (3)
- Periodontitis (3)
- Persistence (3)
- Phosphorylation (3)
- Platelets (3)
- Portal veins (3)
- Pre-analytics (3)
- Preterm birth (3)
- Primary health care (3)
- Primärversorgung (3)
- Prognostic markers (3)
- Progranulin (3)
- Protease inhibitor therapy (3)
- Psoriasis (3)
- Psychiatrie (3)
- Pulmonary hypertension (3)
- Pädiatrie (3)
- Qualitätssicherung (3)
- Questionnaire (3)
- Questionnaires (3)
- RCT (3)
- RITA (3)
- RNA interference (3)
- RNA sequencing (3)
- RNA therapeutics (3)
- Ratgeber (3)
- Ratte (3)
- Rechtsmedizin (3)
- Regression analysis (3)
- Relaxometry (3)
- Reliabilität (3)
- Renal cell carcinoma (3)
- Research Article (3)
- Respiration (3)
- Rezidiv (3)
- Risk assessment (3)
- S1P (3)
- SF-36 (3)
- SNP (3)
- SUDEP (3)
- SUMO (3)
- SVR (3)
- Sarcoma (3)
- Schwangerschaft (3)
- Sensitivität und Spezifität (3)
- Serodiagnosis (3)
- Sexualität (3)
- Simulated patients (3)
- Sleep (3)
- Sphingolipids (3)
- Spiel (3)
- Sports and exercise medicine (3)
- Sprachstörung (3)
- Squamous cell carcinoma (3)
- Stammzelltransplantation (3)
- Statistical data (3)
- Stereotactic body radiation therapy (3)
- Strength training (3)
- Streptococcus pneumoniae (3)
- Sudden cardiac death (3)
- Surgeons (3)
- Synapses (3)
- Synaptic plasticity (3)
- Systematic reviews (3)
- TGF-β (3)
- TGFβ (3)
- TIPS (3)
- TKI (3)
- TSC (3)
- Target identification (3)
- Teaching (3)
- Tele-EEG (3)
- Telemedicine (3)
- Temozolomide (3)
- Tensiomyography (3)
- Thoracic trauma (3)
- Thrombozytenkonzentrat (3)
- Thyroid (3)
- Todesart (3)
- Torque (3)
- Toxicity (3)
- Transarterial chemoembolization (3)
- Type 2 diabetes (3)
- USP28 (3)
- Undergraduate medical education (3)
- Upper body posture (3)
- Validity (3)
- Variant histology (3)
- Vergütung (3)
- Versorgungsqualität (3)
- Wnt (3)
- Women (3)
- Zoonosis (3)
- absent expenditure of material (3)
- accident (3)
- acetylcholine (3)
- actin (3)
- acupuncture (3)
- acute coronary syndromes (3)
- acute decompensation (3)
- acute leukemia (3)
- adenosine (3)
- adherence (3)
- adult (3)
- aged (3)
- albumin (3)
- alcohol use disorder (3)
- allogeneic stem cell transplantation (3)
- alveolar ridge augmentation (3)
- anal cancer (3)
- animal model (3)
- animal models (3)
- anti-angiogenic therapy (3)
- antiviral (3)
- anxiety (3)
- aptamer (3)
- arteriogenesis (3)
- ascites (3)
- aspirin (3)
- astrocytes (3)
- atezolizumab (3)
- attention-deficit/hyperactivity disorder (3)
- autism spectrum disorder (3)
- autologous stem cell transplantation (3)
- bacteria (3)
- bereavement (3)
- biocompatibility (3)
- bleeding (3)
- blood (3)
- blood transfusion (3)
- body mass index (3)
- bone (3)
- bone regeneration (3)
- bortezomib (3)
- brain cancer (3)
- brain imaging (3)
- brain metastasis (3)
- brain stimulation (3)
- brainstem (3)
- burden of illness (3)
- calprotectin (3)
- calretinin (3)
- cancer immunotherapy (3)
- carbapenemases (3)
- cardiac (3)
- caregivers (3)
- cartilage (3)
- caspase-2 (3)
- caspase-8 (3)
- catheter ablation (3)
- cell cycle (3)
- cell proliferation (3)
- chemokines (3)
- chronic myeloid leukemia (3)
- cisplatin (3)
- clinical benefit (3)
- clinical research (3)
- clinical trials (3)
- cochlea (3)
- colon (3)
- comorbidities (3)
- compartmental neuron model (3)
- complex I (3)
- complexome profiling (3)
- computational model (3)
- computational neuroscience (3)
- computational virology (3)
- corona (3)
- cortisol (3)
- critical size defect (3)
- critically ill patients (3)
- cycling (3)
- cytokine-induced killer cells (3)
- decision making (3)
- dental education (3)
- dental profession (3)
- dexamethasone (3)
- diabetic nephropathy (3)
- diagnostic algorithm (3)
- didactic (3)
- diet (3)
- disintegration (3)
- dissolution (3)
- drug induced liver injury (3)
- drug release (3)
- eNOS (3)
- echocardiography (3)
- education (3)
- endocannabinoids (3)
- endoplasmic reticulum (3)
- epidermal growth factor receptor (3)
- episodic memory (3)
- evolution (3)
- fascia (3)
- feedback (3)
- fenfluramine (3)
- focal adhesion (3)
- follow-up (3)
- functional outcome (3)
- fusion (3)
- gamma (3)
- gene regulation (3)
- genetics (3)
- glucose (3)
- growth inhibition (3)
- haemophilia care (3)
- head and neck cancer (3)
- health (3)
- healthcare worker (3)
- heart (3)
- heart rate (3)
- hematopoiesis (3)
- hematopoietic stem and progenitor cells (3)
- hematopoietic stem cells (3)
- hemodialysis (3)
- hepatitis B (3)
- herb induced liver injury (3)
- histone acetylation (3)
- homeostasis (3)
- hyperactivity (3)
- immune cells (3)
- immune checkpoint inhibitors (3)
- immune escape (3)
- immune reconstitution (3)
- immunmodulierende Effekte (3)
- immunomodulatory effects (3)
- immunosuppression (3)
- inertial motion capture (3)
- infectious diseases (3)
- infrared-A radiation (3)
- insulin resistance (3)
- interleukin-22 (3)
- interleukins (3)
- invasive fungal disease (3)
- invasive fungal infection (3)
- iron metabolism (3)
- irradiation (3)
- kidney transplantation (3)
- leptin (3)
- lipidomics (3)
- lipids (3)
- liver injury (3)
- local recurrence (3)
- lockdown (3)
- long-term prophylaxis (3)
- lyme disease (3)
- lymphoma (3)
- mRNA (3)
- magnetoencephalography (3)
- massively parallel multigrid solvers (3)
- meta-analysis (3)
- metastatic (3)
- metformin (3)
- miRNAs (3)
- microdialysis (3)
- microwave ablation (3)
- mild cognitive impairment (3)
- mitochondrial disease (3)
- mitochondrial dysfunction (3)
- mitochondrial respiration (3)
- molecular mechanisms (3)
- monoclonal antibody (3)
- morbidity (3)
- morphology (3)
- mouse model (3)
- multi-scale modeling (3)
- multidrug resistance (3)
- musculoskeletal (3)
- mycophenolic acid (3)
- myocarditis (3)
- nanoparticles (3)
- necroptosis (3)
- neoadjuvant chemotherapy (3)
- neonate (3)
- neoplasms (3)
- neural network (3)
- neurocritical care (3)
- neuromodulation (3)
- neuropathy (3)
- neurophysiology (3)
- neutralization (3)
- neutralizing antibodies (3)
- newborn (3)
- next-generation sequencing (3)
- non-coding RNA (3)
- occupational infections (3)
- oncology (3)
- online survey (3)
- optogenetics (3)
- osteoporosis (3)
- overweight (3)
- oxidative phosphorylation (3)
- p47phox (3)
- pediatric patients (3)
- pentose phosphate pathway (3)
- perforant path transection (3)
- perfusion (3)
- peri-implantitis (3)
- pericarditis (3)
- pharmacodynamics (3)
- pharmacogenetics (3)
- physiotherapy (3)
- plasmid (3)
- platelet-rich fibrin (3)
- pneumonia (3)
- posttraumatic stress disorder (3)
- predictor (3)
- primary prostate cancer (3)
- primary sclerosing cholangitis (3)
- prognostic factors (3)
- prolonged grief disorder (3)
- protein synthesis (3)
- proteoglycan (3)
- proteome (3)
- proteostasis (3)
- quality assurance (3)
- radical prostatecomy (3)
- realistic geometries (3)
- relapse (3)
- relaxometry (3)
- remodelling (3)
- renal cell cancer (3)
- renal function (3)
- reproducibility (3)
- resistance mutation (3)
- resolution (3)
- rituximab (3)
- salvage therapy (3)
- scientometrics (3)
- seizures (3)
- serum (3)
- severe acute respiratory syndrome coronavirus 2 (3)
- sex (3)
- sex differences (3)
- simulation (3)
- soft tissue sarcoma (3)
- sphingolipid (3)
- squamous cell carcinoma (3)
- stress response (3)
- supportive periodontal therapy (3)
- surgical procedures (3)
- synchrony (3)
- systematic biopsy (3)
- systemic antibiotics (3)
- therapeutics (3)
- therapy monitoring (3)
- tobacco prevention (3)
- toll-like receptor (3)
- trafficking (3)
- training (3)
- transcriptome (3)
- transient elastography (3)
- triglycerides (3)
- tumor angiogenesis (3)
- type 1 diabetes (3)
- tyrosine kinase inhibitor (3)
- validity (3)
- vemurafenib (3)
- viral dynamics (3)
- virus (3)
- visual analog scales (VAS) (3)
- visual analogue scales (VAS) (3)
- visual attention (3)
- von Willebrand factor (3)
- working conditions (3)
- zinc (3)
- Ähnlichkeit (3)
- - (2)
- 17-AAG (2)
- 3D spatio-temporal resolved mathematical models (2)
- 5′-UTR (2)
- 6-shogaol (2)
- A/D transition (2)
- ABCC1 (2)
- ABCG2 (2)
- ACL (2)
- AF4 (2)
- AKI (2)
- AKT (2)
- ALK (2)
- AMH (2)
- AMPK (2)
- APP processing (2)
- ARFI (2)
- ATP-citrate lyase (2)
- Abdominelles Aortenaneurysma (2)
- Abort (2)
- Absorption (2)
- Academic medicine (2)
- Access (2)
- Accidental reaction (2)
- Acinetobacter baumannii (2)
- Acne inversa (2)
- Acoustics (2)
- Action potentials (2)
- Activities of daily living (2)
- Acuris (2)
- Acute Myeloid Leukemia (AML) (2)
- Acute decompensation (2)
- Acute leukemia (2)
- Acute lymphocytic leukaemia (2)
- Acute myeloid leukaemia (2)
- Acute seizure plan (2)
- Acute-on-chronic liver failure (2)
- Addiction (2)
- Addison’s disease (2)
- Adipose tissue (2)
- Adipose-derived mesenchymal stem cells (2)
- Adolescence (2)
- Adult neurogenesis (2)
- Adverse drug reaction (2)
- Africa (2)
- Age (2)
- Age estimation (2)
- Aggression (2)
- Akaike information criterion (AIC) (2)
- Akute lymphatische Leukämie (2)
- Akuter Anfallsplan (2)
- Alcohol consumption (2)
- Alcoholic liver disease (2)
- Algorithms (2)
- Alleles (2)
- Allergen avoidance (2)
- Allergic asthma (2)
- Allergy (2)
- Allosteric inhibition (2)
- Alpelisib (2)
- Alpha-synuclein (2)
- Alzheimer-Krankheit (2)
- Anaemia (2)
- Anal cancer (2)
- Analgesia (2)
- Analgesie (2)
- Analyse der Körperzusammensetzung (2)
- Anandamide (2)
- Anatomy (2)
- Angiographie (2)
- Animal model (2)
- Anschlussheilbehandlung (2)
- Anti-IgE (2)
- Anti-seizure medication (2)
- Anticoagulant therapy (2)
- Anticonvulsants (2)
- Antigen test (2)
- Antikonvulsiva (2)
- Antikörpertest (2)
- Antimicrobial resistance (2)
- Antimicrobial treatment (2)
- Antiretrovirals (2)
- Aortic dissection (2)
- Apheresis (2)
- Apixaban (2)
- Appendectomy (2)
- Arbeitsgemeinschaft Sammlung Deutscher Drucke (2)
- Arrhythmia (2)
- Arthroplasty (2)
- Arzneimittel (2)
- Arzneimittelmarkt (2)
- Asphyxia (2)
- Assessment (2)
- Associative memory (2)
- Asthma (2)
- Ataxia (2)
- Atezolizumab (2)
- Attention-deficit/hyperactivity disorder (2)
- Audio signal processing (2)
- Auditory rehabilitation (2)
- Auditory system (2)
- Augenheilkunde (2)
- Aurora A (2)
- Aurora kinase (2)
- Austria (2)
- Autoimmunity (2)
- Autologous biomaterial (2)
- Axons (2)
- Ayurveda (2)
- BA.1 (2)
- BCL2 (2)
- BCL6 (2)
- BCOR (2)
- BCX7353 (2)
- BFR training (2)
- BMNC (2)
- BNT162b2 (2)
- BPH (2)
- BRCA1 (2)
- BRCA2 (2)
- Babesia divergens (2)
- Babesia microti (2)
- Back pain (2)
- Bacteria (2)
- Bacterial biofilms (2)
- Bacterial meningitis (2)
- Balance (2)
- Bartonella henselae (2)
- Bauchaortenaneurysma (2)
- Begriff (2)
- Behandlungsposition (2)
- Benefit (2)
- Berufskrankheit (2)
- Betriebliche Gesundheitsförderung (2)
- Bevacizumab (2)
- Bewegung (2)
- Bewegungsmangel (2)
- Biceps brachii (2)
- Big Data (2)
- Big Five (2)
- Bildgebung (2)
- Bile duct stone (2)
- Biodiversity (2)
- Bioenergetics (2)
- Biofilm (2)
- Bioinformatics (2)
- Biological profile (2)
- Biomedical engineering (2)
- Biomedical informatics (2)
- Biophysical chemistry (2)
- Biophysical models (2)
- Biorecognition strategies (2)
- Biosynthetic mesh (2)
- Bipolar (2)
- Birth weight (2)
- Bleeding (2)
- Blog (2)
- Blood groups (2)
- Blood loss (2)
- Blood loss estimation (2)
- Blood plasma (2)
- Bloodstream infections (2)
- Blow flies (2)
- Blutübertragbare Virusinfektionen (2)
- Body mass index (2)
- Body modification (2)
- Body posture (2)
- Bone density (2)
- Bone marrow aspiration (2)
- Bone marrow-derived mesenchymal stem cells (2)
- Bone metastases (2)
- Borderline personality disorder (2)
- Bowel obstruction (2)
- Breast neoplasms (2)
- Breast tumors (2)
- Bungarus niger (2)
- Burden of disease (2)
- CAM (2)
- CBA (2)
- CC16 (2)
- CCL2 (2)
- CD14 (2)
- CD16 (2)
- CD44 (2)
- CD62 (2)
- CDK9 (2)
- CDKN1A (2)
- CHIP (2)
- CIOMS (2)
- CIRS (2)
- CLN3 (2)
- CLP (2)
- CMV (2)
- CNN (2)
- COVID-19 pandemic (2)
- COVID-19 surveillance (2)
- COVID19-NMR (2)
- CPE (2)
- CRISPR/Cas (2)
- CSM (2)
- CTLA-4 (2)
- CUELA (2)
- CV9202 (2)
- CXCL13 (2)
- Caco-2 cells (2)
- Caenorhabditis elegans (2)
- Callous-unemotional traits (2)
- Calpain (2)
- Calprotectin (2)
- Cancer epidemiology (2)
- Cancer therapy (2)
- Cancer-specific mortality (2)
- Cannabidiol (2)
- Capecitabine (2)
- Carbapenemase (2)
- Carcinoma (2)
- Cardiac arrest (2)
- Cardiac hypertrophy (2)
- Cardiac magnetic resonance (2)
- Cardioprotection (2)
- Cardiovascular biology (2)
- Carotisstenose (2)
- Case management (2)
- Cats (2)
- Causality assessment (2)
- Celiac disease (2)
- Cell binding (2)
- Cell death (2)
- Cell death and immune response (2)
- Cell differentiation (2)
- Cell division (2)
- Cell salvage (2)
- Cellular Immune Response (2)
- Cerebral cortex (2)
- Checkpoint inhibitor (2)
- Chemokines (2)
- Chemoprevention (2)
- Chemotherapie (2)
- Child abuse (2)
- Children and adolescents (2)
- Chinesische Medizin (2)
- Chirurgie (2)
- Chlorides (2)
- Cholangiography (2)
- Cholangiopancreatography (2)
- Chondrocytes (2)
- Chronic depression (2)
- Chronic disease (2)
- Chronic hepatitis (2)
- Chronic inflammation (2)
- Chronic obstructive pulmonary disease (2)
- Chronisch-myeloische Leukämie (2)
- Clinical Global Impression of Change (2)
- Clinical presentation (2)
- Clinical studies (2)
- Clinical study (2)
- Clustering (2)
- Cocaine (2)
- Cochleaimplantation (2)
- Collagens (2)
- Colloids (2)
- Colonoscopy (2)
- Community based intervention (2)
- Community health services (2)
- Complexity (2)
- Complication management (2)
- Computational biology and bioinformatics (2)
- Computational model (2)
- Computational neuroscience (2)
- Computational science (2)
- Computer hardware (2)
- Computer science (2)
- Computertomographie (2)
- Connectomics (2)
- Coronary artery disease (2)
- Cortex (2)
- Cost-effectiveness (2)
- Croatia (2)
- Crohn's disease (2)
- CspZ (2)
- Cuela (2)
- Curriculum (2)
- CyberKnife robotic radiosurgery (2)
- CysLTR1 (2)
- Cytogenetics (2)
- Cytologie (2)
- Cytoskeletal proteins (2)
- DEPDC5 (2)
- DMARDs (biologic) (2)
- DNA (2)
- DOMS (2)
- DSM (2)
- Daptomycin (2)
- Database searching (2)
- Datenschutz (2)
- Datenverarbeitung (2)
- Decision trees (2)
- Defibrillation (2)
- Degradation (2)
- Demenz (2)
- Dengue (2)
- Dengue virus (2)
- Density-equalizing mapping (2)
- Dental implants (2)
- Dentist (2)
- Dentists (2)
- Dermatologie (2)
- Diagnostic algorithm (2)
- Diagnostic test (2)
- Dialyse (2)
- Dicer (2)
- Differential diagnosis (2)
- Differentiation (2)
- Differenzierung (2)
- Digestive system procedures (2)
- Digitalization (2)
- Direct current electrical stimulation (2)
- Directly acting antiviral agent (2)
- Disc herniation (2)
- Disease Activity (2)
- Disintegration (2)
- Distance to water (2)
- Docetaxel (2)
- Double-balloon enteroscopy (2)
- Drug development (2)
- Drug discovery (2)
- Dynamic MRI (2)
- E. coli (2)
- E3 ligase (2)
- EBM (2)
- EEG-fMRI (2)
- EET (2)
- EMT (2)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (2)
- EQ-5D (2)
- ERP (2)
- ESBL (2)
- EWSR1 (2)
- Ears (2)
- Ebola virus (2)
- Ecosystem services (2)
- Edinger, Ludwig (2)
- Edoxaban (2)
- Efficacy (2)
- Electrical stimulation (2)
- Electroencephalography – EEG (2)
- Electrophysiology (2)
- Elevation (2)
- Emotion (2)
- Empathy (2)
- EndMT (2)
- Endocannabinoid (2)
- Endocannabinoids (2)
- Endokrinologie (2)
- Endometriosis (2)
- Endoscopic retrograde (2)
- Endoscopic ultrasound (2)
- Endothel (2)
- Endothelial permeability (2)
- Endotoxin (2)
- Endovaskuläre Behandlung (2)
- Ensemble learning (2)
- Enterobacteriaceae (2)
- Enterscopy (2)
- Environmental support (2)
- Enzyme-linked Immunosorbent Assay (2)
- Enzyme-linked immunoassays (2)
- EphB4 (2)
- Epicutaneous immunotherapy (2)
- Epidemiologie (2)
- Epidemiology and End Results (2)
- Epidermal growth factor receptor (2)
- Epileptic seizures (2)
- Episodic memory (2)
- Epstein-Barr virus (2)
- Equity (2)
- Ergonomics (2)
- Erwachsene (2)
- Erweiterter Suizid (2)
- Etiology (2)
- Euthanasie <Nationalsozialismus> (2)
- Evidence-based (2)
- Evidence-based dentistry (2)
- Evidenzbasierte Medizin (2)
- Extended donor criteria (2)
- Extended suicide (2)
- Extracellular matrix proteins (2)
- FEV1 (2)
- FFPE (2)
- FHIR (2)
- FLT3-ITD (2)
- Face (2)
- Fachsprache (2)
- Family practice (2)
- Fatty liver (2)
- Fertilität (2)
- Fertilité (2)
- Fettstoffwechsel (2)
- Fibroblasts (2)
- Finanzierung (2)
- Flaps (2)
- Flexibility (2)
- Follow-up treatment (2)
- Forensische Osteologie (2)
- Fortbildung (2)
- Fragebogen (2)
- Frailty (2)
- Frankfurt am Main (2)
- Früherkennung (2)
- Fuchs endothelial dystrophy (2)
- Function (2)
- Functional characterization (2)
- Functional electrical stimulation (2)
- Funding (2)
- Fußkurbelergometerausdauerbelastung (2)
- G2A (2)
- GABA (2)
- GEMs (2)
- GFAP (2)
- GWAS (2)
- Gadobutrol (2)
- Galaktografie (2)
- Galaktomosynthese (2)
- Gaming disorder (2)
- Gastritis (2)
- Gastrointestinal bleeding (2)
- Gastroschisis (2)
- Gehen (2)
- Gelenkersatz (2)
- Gemeinschaftliche Selbsttötung (2)
- Gender reassigning surgery (2)
- Gene (2)
- Gene ontology (2)
- General practitioners (2)
- Genetic engineering (2)
- Genetic testing (2)
- Genetik (2)
- Genexpression (2)
- Genregulation (2)
- Gentherapie (2)
- Geographic variation (2)
- Geographically weighted regression (GWR) (2)
- Geriatric patients (2)
- German people (2)
- Geschichte 1801-1870 (2)
- Gesetz zur Verhütung erbkranken Nachwuchses (2)
- Gesichtsauflösung (2)
- Gewalt (2)
- Gezielte Therapie (2)
- Ginkgoblatt-Extrakt (2)
- Glaucoma (2)
- Gleason score (2)
- Glucose metabolism (2)
- Glycolysis (2)
- Grafts (2)
- Growth factors (2)
- Guideline (2)
- HBsAg (2)
- HCMV (2)
- HDACi (2)
- HES (2)
- HIV protease inhibitors (2)
- HIV-Infektion (2)
- HL7 FHIR (2)
- HLA class I (2)
- HNO (2)
- HOD (2)
- HRM (2)
- HSV (2)
- HSV-1 (2)
- HUVEC (2)
- Hals-Nasen-Ohren-Heilkunde (2)
- Hashimoto-Thyreoiditis (2)
- Hausarzt (2)
- Hausarztmangel (2)
- Hausarztpraxis (2)
- HeLa cells (2)
- Health care workers (2)
- Health policy (2)
- Health services (2)
- Healthcare personnel (2)
- Healthcare resource utilization (2)
- Heart rate (2)
- Heilkunde (2)
- Hematologic malignancies (2)
- Hemodynamics (2)
- Hepatitis B virus (2)
- Herpes Zoster Infektion (2)
- Herpes-simplex-Virus (2)
- Herzinfarkt (2)
- Herztransplantation (2)
- Heterogeneity (2)
- High oblique sagittal osteotomy (2)
- High-density lipoprotein (2)
- High-density-Lipoproteine HDL (2)
- Hirninfarkt (2)
- Hirntumor (2)
- Histologie (2)
- Holmes tremor (2)
- Homicide (2)
- Hospital (2)
- Host-biofilm interactions (2)
- HuR (2)
- Human (2)
- Hypertonie (2)
- Hörrehabilitation (2)
- Hörrinde (2)
- Hüfte (2)
- IAPs (2)
- ICD-11 (2)
- IDH mutation (2)
- IHC (2)
- IKZF1 (2)
- IL-10 (2)
- IL-12 (2)
- IL-33 (2)
- IR-A (2)
- ISR (2)
- Identification (2)
- Ileus (2)
- Image analysis (2)
- Imatinib mesilat (2)
- Imeetto (2)
- Immune Response (2)
- Immune suppression (2)
- Immune system (2)
- Immunenzymtechniken (2)
- Immunity (2)
- Immunität <Medizin> (2)
- Immunmodulation (2)
- Immunoenzyme Techniques (2)
- Immunogenicity (2)
- Immuntherapie (2)
- Immunturbidimetrie (2)
- Impfraten (2)
- Implementation (2)
- In vivo (2)
- Incidence rate (2)
- Incisional hernia (2)
- Indirect-binding (2)
- Indonesia (2)
- Infection control (2)
- Infektiologie (2)
- Infektion (2)
- Information theory (2)
- Injuries (2)
- Innate Immunity (2)
- Innate immune response (2)
- Insulin signalling (2)
- Integration (2)
- Integrin (2)
- Integrins (2)
- Intelligence (2)
- Intensive care treatment (2)
- Interaktion (2)
- Interdisciplinarity (2)
- Interdisziplinarität (2)
- Interferon (2)
- Interleukin-1 (2)
- Intervention (2)
- Interventionsversuch (2)
- Iron (2)
- Iron deficiency (2)
- Iron deficiency anemia (2)
- Ischemia/reperfusion injury (2)
- Joint loading (2)
- Jumping (2)
- KGF (2)
- Katherine (2)
- Ketogenic diet (2)
- Ki-67 (2)
- Kinases (2)
- Kinderkrankheit (2)
- Klassifikation (2)
- Klebsiella pneumoniae (2)
- Klinische Ergebnisse (2)
- Klinische Kompetenz (2)
- Knochen (2)
- Kolorektales Karzinom (2)
- Kompetenzen (2)
- Komplementsystem (2)
- Komplikation (2)
- Krankenversicherung (2)
- Krebs (2)
- Kunst (2)
- Körpergewicht (2)
- Körperhaltung (2)
- Körpermasseindex BMI (2)
- L-DOPA (2)
- LPS (2)
- LSCC (2)
- LVAD (2)
- Labordiagnostik (2)
- Laktat (2)
- Lamivudine (2)
- Landarztprogramm (2)
- Laparoskopie (2)
- Lasers (2)
- Laufband (2)
- Left hemisphere (2)
- Leistungsfähigkeit (2)
- Leptin (2)
- Leukemias (2)
- Leukocytes (2)
- Leukotriene (2)
- Lipid signalling (2)
- Lipidomics (2)
- Lipolyse (2)
- Liposomes (2)
- Literatur (2)
- Liver (2)
- Liver cancer (2)
- Liver injury (2)
- Livestock (2)
- Local climate (2)
- Local therapy (2)
- Lokalrezidiv (2)
- Long-term potentiation (2)
- Longitudinal (2)
- Low-density-Lipoproteine LDL (2)
- Low-molecular-weight heparin (2)
- Low-virulent infection (2)
- Luciferase (2)
- Lucilia sericata (2)
- Lung cancer (2)
- Lungenfunktion (2)
- Lyme disease (2)
- Lymph nodes (2)
- Lymphectasia (2)
- Lymphocytes (2)
- Lymphom (2)
- Lymphoma (2)
- Lysophosphatidic acids (2)
- Lysosome (2)
- M2-PK (2)
- MALAT1 (2)
- MCI (2)
- MHC (2)
- MICA (2)
- MLH1 (2)
- MLKL (2)
- MLL-r leukemia (2)
- MMP9 (2)
- MR spectroscopy (2)
- MRP4 (2)
- MSC (2)
- MTT assay (2)
- Macroautophagy (2)
- Magnetic resonance (2)
- Makhuwa-Meetto (2)
- Makrophagen (2)
- Malaria prevalence (2)
- Malnutrition (2)
- Mamma (2)
- Marburg virus (2)
- Markovianity (2)
- Mastectomy (2)
- Maxillary sinus (2)
- Medical consultation (2)
- Medical diagnostics (2)
- Medication Appropriateness Index (2)
- Medicine (2)
- Medizinische Ethik (2)
- Medizinsoziologie (2)
- Meldepflicht (2)
- Membrane potential (2)
- Memory (2)
- Memory consolidation (2)
- Mensch (2)
- Mental imagery (2)
- Mesh (2)
- Metastasis (2)
- Metastatic (2)
- Metastatic breast cancer (2)
- Metastatic castration-resistant prostate cancer (2)
- Mice (2)
- Microarray (2)
- Microglia (2)
- Microsurgery (2)
- Migrants (2)
- Minimal residual disease (2)
- Mitochondrial ROS (2)
- Mitochondrial complex I (2)
- Mitosis (2)
- MitraClip (2)
- Mixed methods (2)
- Mobilization (2)
- Model (2)
- Molecular autopsy (2)
- Molecular profiling (2)
- Molecular subtypes (2)
- Monocytes (2)
- Morbus Basedow (2)
- Morphometry (2)
- Mountain (2)
- Multidrug resistance (2)
- Multimorbidität (2)
- Multiple Sklerose (2)
- Multiple chronic conditions (2)
- Multivariable analysis (2)
- Multivariate Analyse (2)
- Music (2)
- Muskuloskeletale Erkrankungen (2)
- Mutation (2)
- Mutations (2)
- Mycobacterium tuberculosis (2)
- Myeloid Neoplasia (2)
- Myocardial perfusion (2)
- Myocarditis (2)
- Myokardinfarkt (2)
- Myokarditis (2)
- NADH:ubiquinone oxidoreductase (2)
- NCCN (2)
- NCoR1 (2)
- NF-κB pathway (2)
- NFκB (2)
- NK cells (2)
- NMR (2)
- NOTCH1 (2)
- NR4A2 (2)
- NS-Medizin (2)
- NS3 (2)
- Nachsorge (2)
- Nachweismethoden (2)
- Nachweisverfahren (2)
- Nadelstichverletzungen (2)
- Necrotizing enterocolitis (2)
- Neoplasms (2)
- Nepal (2)
- Nephrectomy (2)
- Nerve regeneration (2)
- Neugeborenes (2)
- Neural circuits (2)
- Neural stem cells (2)
- Neuroimaging (2)
- Neurologie (2)
- Neuron (2)
- Neuronal dendrites (2)
- Neuronal morphology (2)
- Neuronal plasticity (2)
- Neuropathic pain (2)
- Neurophysiologie (2)
- Neurophysiology (2)
- Neurosurgery (2)
- Neurotoxicity (2)
- Neurotransmitter (2)
- Nevirapine (2)
- Nicotine (2)
- Non-coding RNA (2)
- Non-interventional study (2)
- Normal distribution (2)
- Notaufnahme (2)
- Notfallmedizin (2)
- Nox1 (2)
- Nucleic acid biomarkers (2)
- Nuklearmedizin (2)
- Numerical simulation (2)
- Nutrition (2)
- OCT (2)
- Object vision (2)
- Observational (2)
- Obstetrics and gynecology (2)
- Occupational disease (2)
- Olfactory system (2)
- Onkologie (2)
- Operation/Chirurgie (2)
- Ophthalmology (2)
- Opioids (2)
- Opportunistic infections (2)
- Oral immunotherapy (2)
- Oral surgery (2)
- Ordinary least squares (OLS) (2)
- Organ dysfunction (2)
- Organ dysfunctions (2)
- Organ preservation (2)
- Organoids (2)
- Oroantral (2)
- Orthognathic surgery (2)
- Osteogenic differentiation (2)
- Outcome assessment (2)
- Outcomes research (2)
- Outpatients (2)
- Ovarian cancer (2)
- Oxidative stress (2)
- OxyELITE Pro (2)
- P2X7 receptor (2)
- PAC-1 (2)
- PAH (2)
- PARP (2)
- PC12 cells (2)
- PD-1 (2)
- PD1/ PDL1 (2)
- PD‑L1 (2)
- PET (2)
- PGE2 (2)
- PINK1 (2)
- PLGA (2)
- PML (2)
- PPARγ (2)
- PRF (2)
- PRNT (2)
- PROTAC (2)
- PTEN (2)
- Pacemaker (2)
- Pain management (2)
- Pain sensation (2)
- Palliative care (2)
- Palliative care [MeSH] (2)
- Parenteral nutrition (2)
- Parkin (2)
- Parkinson (2)
- Parkinson disease (2)
- Particulate matter (2)
- Pathologic complete response (2)
- Pathology (2)
- Patient (2)
- Patient Blood Management (2)
- Patient manikins (2)
- Patient needs (2)
- Patient preference (2)
- Patient-centred care (2)
- Patientenbedürfnisse (2)
- Patientenverfügung (2)
- Patterns of care (2)
- Pediatric infections (2)
- Pelargonium sidoides (2)
- Penile cancer (2)
- Pentaglobin (2)
- Percutaneous coronary intervention (2)
- Perikarditis (2)
- Periodontal therapy (2)
- Periodontal treatment (2)
- Periphere arterielle Verschlusskrankheit (2)
- Peritonitis (2)
- Permutation (2)
- Persistent wound infections (2)
- Person-Umwelt-Passung (2)
- Person-environment fit (2)
- Personal- und Organisationsentwicklung (2)
- Personalisierte translationale Therapie (2)
- Petri net (2)
- Pflege (2)
- Philadelphia chromosome (2)
- Phylogenetic analysis (2)
- Physical environment (2)
- Physics (2)
- Physikalische Medizin (2)
- Physikalische Therapie (2)
- Plasma (2)
- Plasmodium (2)
- Plattenepithelcarcinom (2)
- Plerixafor (2)
- Plk1 inhibitors (2)
- Pneumocystis jirovecii (2)
- Pneumoperitoneum (2)
- Podospora anserina (2)
- Point-of-care testing (2)
- Police (2)
- Post-mortem interval (2)
- Post-translational modifications (2)
- Post-traumatic stress disorder (2)
- Postoperative radiochemotherapy (2)
- Posttraumatische Belastungsstörung (2)
- Posture analysis (2)
- Poverty (2)
- Practical skills (2)
- Predictive coding (2)
- Predominant polarity (2)
- Preeclampsia (2)
- Primary cilium (2)
- Prisoners (2)
- Prisons (2)
- Probability density (2)
- Probability distribution (2)
- Procalcitonin (2)
- Professional dance (2)
- Professionalisierung (2)
- Prognose (2)
- Prognosefaktoren (2)
- Prognostic (2)
- Prognostic tool (2)
- Programm (2)
- Prostataspezifisches Antigen (2)
- Prostatic neoplasms (2)
- Proteasome (2)
- Protein biomarkers (2)
- Protein degradation (2)
- Protein synthesis (2)
- Protein translation (2)
- Proteins (2)
- Prädiktive Validität (2)
- Prädiktivfaktoren (2)
- Präkonditionierung (2)
- Prävalenz (2)
- Pseudomonas aeruginosa (2)
- Psychedelics (2)
- Psychoanalyse (2)
- Psychological stress (2)
- Psychopathology (2)
- Psychopharmaka (2)
- Psychotherapie (2)
- Pulmonary veins (2)
- Qualitative research (2)
- Quality indicators (2)
- Qualitätsmanagement (2)
- Quarantine (2)
- Quinine (2)
- RAS (2)
- RBFOX1 (2)
- RDoC (2)
- RIPK3 (2)
- RMS (2)
- RNA binding proteins (2)
- RNA interference (RNAi) (2)
- RNA isolation (2)
- RNA processing (2)
- RNA therapy (2)
- RNA-binding protein (2)
- RNA-binding proteins (2)
- RNA-sequencing (2)
- RNAseq (2)
- ROS1 (2)
- Rab7 (2)
- Radiation (2)
- Radical prostatectomy (2)
- Radiochemotherapy (2)
- Radiologie (2)
- Rainfall (2)
- Random forest (2)
- Randomized controlled trials (2)
- Reanimation (2)
- Recurrence (2)
- Red blood cell transfusion (2)
- Redoxin (2)
- Refractory ALL (2)
- Refugees (2)
- Rehabilitation outcome (2)
- Rehabilitationsergebnis (2)
- Rejection (2)
- Reliability (2)
- Remuneration (2)
- Renal system (2)
- Reproducibility (2)
- Rescue medication (2)
- Research architecture (2)
- Respiratory chain (2)
- Respiratory distress syndrome (2)
- Respiratory infections (2)
- Restenosis (2)
- Resting state (2)
- Resting-state (2)
- Retina (2)
- Return to play (2)
- Reward (2)
- Rheumatoid Arthritis (2)
- Ribavirin (2)
- Richtlinie (2)
- Risikofaktoren (2)
- Risk factor (2)
- Risk stratification (2)
- Rivaroxaban (2)
- Roussel Uclaf Causality Assessment Method (RUCAM) (2)
- Rural area (2)
- Rückenschmerzen (2)
- S1P lyase (2)
- S1P receptors (2)
- SAMHD1 (2)
- SARS (2)
- SARS coronavirus (2)
- SARS-CoV-2 monitoring (2)
- SARS-CoV-2 testing (2)
- SARS-CoV‑2 (2)
- SARS‐CoV‐2 (2)
- SCC (2)
- SCCHN (2)
- SD-OCT (2)
- SENP (2)
- SIRS (2)
- SIRT1 (2)
- SMAD (2)
- SOD (2)
- SPM (2)
- SPTAN1 (2)
- STAT1 (2)
- STING (2)
- SUMOylation (2)
- SV2A (2)
- Sarcoidosis (2)
- Sauerstoff (2)
- Scheimpflug imaging (2)
- Schilddrüsenfunktion (2)
- Schilddrüsenknoten (2)
- Schizophrenie (2)
- Schmerztherapie (2)
- Scientists (2)
- Seizures (2)
- Selbstmanagement (2)
- Self-management (2)
- Self-renewal (2)
- Senescence (2)
- Sensitivität (2)
- Sensory processing (2)
- Serin (2)
- Serodiagnose (2)
- Seroprevalence (2)
- Serum (2)
- Sestrin 2 (2)
- Sholl analysis (2)
- Short bowel syndrome (2)
- Shunt (2)
- Simulation and modeling (2)
- Simulation training (2)
- Skills (2)
- Smac mimetic (2)
- Small molecules (2)
- Smoking habits (2)
- Snakebite (2)
- Social Media (2)
- Social epidemiology (2)
- Social health determinants (2)
- Social neuroscience (2)
- Social participation (2)
- Social phobia (2)
- Socio-economic analysis (2)
- Socioeconomic status (2)
- Solution NMR spectroscopy (2)
- Sonication (2)
- Sorafenib (2)
- Soziologie (2)
- Specificity (2)
- Speech discrimination (2)
- Speech signal processing (2)
- Spezifität (2)
- Spinal cord (2)
- Spine (2)
- Spiroergometrie (2)
- Sprache (2)
- Sprachverstehen (2)
- Sprechen (2)
- Sprechstörung (2)
- Staff development (2)
- Standard endoscopy (2)
- Standard value (2)
- Standardization (2)
- Stem-cell therapies (2)
- Sterblichkeit (2)
- Stereotaxie (2)
- Stickstoffmonoxid (2)
- Striatum (2)
- Stroke unit (2)
- Structural biology (2)
- Structural plasticity (2)
- Study protocol (2)
- Subarachnoid hemorrhage (2)
- Sudden death (2)
- Suicide pact (2)
- Suizidalität (2)
- Sumatra (2)
- Sunitinib (2)
- Superficial vein thrombosis (2)
- Superoxide (2)
- Supplementation (2)
- Supported decision making (2)
- Supportivtherapie (2)
- Survey (2)
- Survival analysis (2)
- Survivin (2)
- Sweden (2)
- Synaptic transmission (2)
- Synovial sarcoma (2)
- Systemic inflammation (2)
- Systemic therapy (2)
- T-Zellen (2)
- T-cell (2)
- T-cell targeting (2)
- T-cells (2)
- TBSS (2)
- TEP (2)
- TF-complexes (2)
- TGF-β1 (2)
- THR (2)
- TIGAR (2)
- TLR (2)
- TMT (2)
- TRPA1 (2)
- Tailored therapy (2)
- Target validation (2)
- Targeted therapies (2)
- Teeth (2)
- Tenofovir (2)
- Tetrahydrobiopterin (2)
- Thailand (2)
- Theft (2)
- Thromboembolism (2)
- Thrombolysis (2)
- Thrombophilie (2)
- Thrombotic thrombocytopenic purpura (2)
- Tight junctions (2)
- Toll-like receptor (2)
- Tomography (2)
- Tomography (x-ray computed) (2)
- Tomosynthese (2)
- Tooth loss (2)
- Transcription (2)
- Transcription Factors (2)
- Transfusionsmedizin (2)
- Transgender (2)
- Translation (2)
- Transmission (2)
- Transplantatabstoßung (2)
- Transplantation (2)
- Traumatic brain injury (2)
- Traumatic injury (2)
- Treatment position (2)
- Treg cell (2)
- Triglyzeride (2)
- Troponin (2)
- Tuberculosis (2)
- Tumor (2)
- Tumor marker (2)
- Tumour immunology (2)
- Tyrosinkinasen (2)
- T‑DM1 (2)
- UGCG (2)
- USA (2)
- Ubiquitin (2)
- Ubiquitylation (2)
- Ulcerative colitis (2)
- Ultrasonography (2)
- Universität Frankfurt am Main (2)
- Unsterblichkeit (2)
- Unterstützung der Umwelt (2)
- Urethral cancer (2)
- Urology (2)
- Usability (2)
- Uteroglobin (2)
- V4 (2)
- VDR (2)
- VEGF receptors (2)
- VIGALL (2)
- VRE (2)
- VT (2)
- Vaccine (2)
- Vaccine uptake rate (2)
- Vascular endothelial growth factor (VEGF) (2)
- Veins (2)
- Vemurafenib (2)
- Versorgung (2)
- Versorgungsforschung (2)
- Versorgungsstrukturen (2)
- Viral Load (2)
- Viral infection (2)
- Virologie (2)
- Virulence (2)
- Viruslast (2)
- Virussicherheit (2)
- Visual acuity (2)
- Visual cortex (2)
- Visual estimation (2)
- Visual quality (2)
- Vitamin D deficiency (2)
- Vmem (2)
- Volume therapy (2)
- Voxel-based morphometry (2)
- Vulnerability (2)
- Warburg effect (2)
- Wearable cardioverter-defibrillator (2)
- Web 2.0 (2)
- Weight loss (2)
- Weiterbildung (2)
- Western blot (2)
- White blood cells (2)
- Wissenschaftsgeschichte (2)
- Working memory (2)
- Wortschatz (2)
- Wounds (2)
- Wundversorgung (2)
- Yoga (2)
- Zahnmedizin (2)
- Zebrafish (2)
- Zellkultur (2)
- Zentralnervensystem (2)
- Zigarette (2)
- Zika fever (2)
- Zingiber officinale Roscoe (2)
- Zink (2)
- Zoopotentation (2)
- Zooprophylaxis (2)
- ablation (2)
- abuse (2)
- accelerometry (2)
- acetyl-CoA (2)
- active aging (2)
- acute lung injury (2)
- acute myeloid leukaemia (2)
- acute respiratory distress syndrome (2)
- adalimumab (2)
- adaptations to microgravity (2)
- additive manufacturing (2)
- additives (2)
- adenovirus (2)
- adipocytes (2)
- adipose-derived mesenchymal stem cells (2)
- adipose-derived stromal/stem cells (2)
- adjuvant chemotherapy (2)
- admission test (2)
- adolescence (2)
- adolescent (2)
- adoptive cancer immunotherapy (2)
- adoptive immunotherapy (2)
- adult neurogenesis (2)
- advanced (2)
- advanced care planning (2)
- adverse reaction (2)
- age-related macular degeneration (2)
- ageing (2)
- air flow (2)
- alcoholic liver disease (2)
- algorithm (2)
- allogeneic hematopoietic stem cell transplantation (2)
- allostery (2)
- alpelisib (2)
- alpha power (2)
- alpha-synuclein (2)
- alzheimer’s disease (2)
- ambulatory assessment (2)
- amino acids (2)
- amphiregulin (2)
- amyotrophic lateral sclerosis (ALS) (2)
- analgesia (2)
- analgesics (2)
- analysis of body composition (2)
- anaplastic large cell lymphoma (2)
- angiography (2)
- animal experiment (2)
- animal experiments (2)
- ankyrin (2)
- anorexia nervosa (2)
- antibiotic resistance (2)
- antibiotic therapy (2)
- antibody (2)
- antibody test (2)
- anticoagulation (2)
- anticonvulsants (2)
- antiepileptic drug (2)
- antiepileptic drugs (2)
- antifungal therapy (2)
- antigen (2)
- antioxidant (2)
- antiseizure medication (2)
- antisocial behavior (2)
- antiviral drugs (2)
- arachidonic acid (2)
- arousal (2)
- arthritis (2)
- assessment (2)
- astrocytoma (2)
- athletes (2)
- attachment loss (2)
- autism (2)
- autoantibodies (2)
- autoimmune diabetes (2)
- autoimmune disease (2)
- autoimmunity (2)
- automation (2)
- autopsy (2)
- axon bifurcation (2)
- back pain (2)
- baicalein (2)
- bats (2)
- benchmarking (2)
- betulinic acid (2)
- bibliometric analysis (2)
- bicycle ergometer endurance exercise (2)
- biliary stricture (2)
- bio imaging (2)
- bio-enabling formulations (2)
- bioavailability (2)
- biochemistry (2)
- bioenergetics (2)
- bioequivalence (2)
- biofilm (2)
- biologics (2)
- bioluminescence (2)
- biopsy (2)
- biopsy cores (2)
- blood borne infection (2)
- blood flow restriction (2)
- blood pressure (2)
- blood-brain barrier (2)
- bloodborne viruses (2)
- blood–brain barrier (2)
- blutübertragbare Infektionskrankheiten (2)
- body mass index BMI (2)
- body plethysmography (2)
- body weight (2)
- bone healing (2)
- bone marrow microenvironment (2)
- bone marrow mononuclear cells (2)
- bone metabolism (2)
- bone metastasis (2)
- borrelia (2)
- boswellic acids (2)
- brain (2)
- brain networks (2)
- brain states (2)
- brain tumor (2)
- brain-derived neurotrophic factor (2)
- broadly neutralizing antibodies (2)
- bromodomains (2)
- bulimia nervosa (2)
- c-MYC (2)
- cAMP (2)
- cART (2)
- cGKI (2)
- cabozantinib (2)
- calcitriol (2)
- callous-unemotional traits (2)
- campesterol (2)
- cancer cell metabolism (2)
- cancer specific survival (2)
- cancer therapy (2)
- cancer treatment (2)
- cancer-associated fibroblasts (2)
- cancer-specific mortality (2)
- cancer-specific survival (2)
- cannabis (2)
- capsaicin (2)
- carbapenem resistance (2)
- carbapenemase (2)
- carcinoma (2)
- cardiovascular (2)
- cardiovascular diseases (2)
- case-referent study (2)
- caspase-1 (2)
- cataract surgery (2)
- cell culture (2)
- cell motility (2)
- cells (2)
- central nervous system (2)
- ceramide (2)
- cerebral hemorrhage (2)
- cerebral ischemia (2)
- cerebral protection (2)
- cerebral venous thrombosis (2)
- cerebrovascular disease (2)
- cesarean section (2)
- chemotaxis (2)
- chemotherapy resistance (2)
- chest trauma (2)
- childhood (2)
- childhood acute myeloid leukemia (2)
- childhood cancer (2)
- children and adolescents (2)
- cholestanol (2)
- cholesterol absorption (2)
- cholesterol synthesis (2)
- chronic granulomatous disease (2)
- chronic hepatitis C (2)
- chronic infection (2)
- chronic inflammation (2)
- chronic thromboembolic pulmonary hypertension (2)
- chronic wounds (2)
- chronische Wunden (2)
- chronobiology (2)
- cigarette (2)
- circadian rhythm (2)
- circadian rhythms (2)
- circular RNA (2)
- cisplatin resistance (2)
- citation (2)
- citrate (2)
- cleaning (2)
- clinical immunology (2)
- clinical isolates (2)
- clinical studies (2)
- clinically important restrictions and symptoms (2)
- clock genes (2)
- clonal dominance (2)
- clonal hematopoiesis (2)
- coagulopathy (2)
- colon carcinoma cells (2)
- colorectal cancer (CRC) (2)
- colorectal carcinoma (2)
- combination therapies (2)
- communication (2)
- comorbidity (2)
- complementary and alternative medicine (2)
- complementary medicine (2)
- complex systems (2)
- compliance (2)
- computational modeling (2)
- computer-assisted (2)
- concordance (2)
- consensus (2)
- constipation (2)
- contemporary (2)
- continuous performance test (2)
- convulsive seizures (2)
- coping (2)
- corneal edema (2)
- corneal transplantation (2)
- corona virus (2)
- coronary artery bypass graft surgery (2)
- coronary artery disease (2)
- corpus callosum (2)
- cost-effective (2)
- counseling (2)
- criticality (2)
- cryoballoon (2)
- cryopreservation (2)
- cyclooxygenase (2)
- cyclosporin A (2)
- cyclosporine (2)
- cytochrome P450 2E1 (2)
- cytokine (2)
- cytotoxic T cells (2)
- dabrafenib (2)
- dance (2)
- data quality (2)
- deafness (2)
- decompensated liver cirrhosis (2)
- dedifferentiation (2)
- delay (2)
- delirium (2)
- dental assistant (2)
- dental assistants (2)
- dentists (2)
- dentoalveolar surgery (2)
- desensitization (2)
- dialysis (2)
- dietary supplements (2)
- dihydroceramide (2)
- disease burden (2)
- disease models (2)
- disease progression (2)
- dislocation (2)
- distress (2)
- docetaxel (2)
- dorsal root ganglia (2)
- doxycycline (2)
- drug-induced liver injury (2)
- drugs (2)
- dual task (2)
- dysphagia (2)
- e-Learning (2)
- eLearning (2)
- eating disorders (2)
- economic burden (2)
- economy (2)
- eicosanoids (2)
- elderly patients (2)
- electrocardiography (2)
- electron transport chain (2)
- emergency care (2)
- endodontic curriculum (2)
- endodontic education (2)
- endothelial (2)
- endothelial cell (2)
- endothelium (2)
- endovascular treatment (2)
- entorhinal cortex lesion (2)
- ephrinB2 (2)
- epidemics (2)
- epidermal growth factor (2)
- epidermis (2)
- epileptic encephalopathy (2)
- epileptogenesis (2)
- epithelial cells (2)
- epithelial to mesenchymal transition (2)
- erectile dysfunction (2)
- erythrocyte (2)
- erythropoietin (2)
- esophageal cancer (2)
- euthymic (2)
- event-related potentials (2)
- exercise countermeasure (2)
- expertise (2)
- extraversion (2)
- eye movements (2)
- factor H (2)
- fall (2)
- farnesoid X receptor (2)
- fasting (2)
- fat-free-mass (2)
- feasibility (2)
- fecal occult blood test (2)
- female subjects (2)
- femoral artery ligation (2)
- ferric carboxymaltose (2)
- fibrinolysis (2)
- focal therapy (2)
- follow‑up (2)
- fortgeschritten (2)
- fracture (2)
- fragment screening (2)
- frankincense (2)
- frontal cortex (2)
- functional genetics (2)
- functional genomics (2)
- fungi (2)
- funktionelle Bildgebung (2)
- furcation involvement class III (2)
- fusion biopsy (2)
- fäkaler okkulter Stuhltest (2)
- gait analysis (2)
- galactography (2)
- galactomosynthesis (2)
- gallbladder cancer (2)
- gallbladder cancer xenografts (2)
- gaming disorder (2)
- gamma oscillations (2)
- gangliosides (2)
- gene signature (2)
- genes (2)
- genetic diversity (2)
- genetic markers (2)
- genetic predisposition (2)
- genetic variants (2)
- genome (2)
- glucose metabolism (2)
- growth factor (2)
- guidebook (2)
- guided bone regeneration (2)
- haemophilia (2)
- haemophilia A (2)
- head and neck neoplasms (2)
- head and neck squamous cell carcinoma (2)
- health care (2)
- health information exchange (2)
- health services research (2)
- healthcare personnel (2)
- healthcare workers (2)
- hedgehog signaling (2)
- hemodynamic (2)
- hemorrhagic transformation (2)
- hepatic encephalopathy (2)
- hepatitis B virus (2)
- hepatotoxicity (2)
- herbal hepatotoxicity (2)
- herpes zoster (2)
- high density lipoproteins HDL (2)
- high-throughput sequencing (2)
- hip (2)
- hippocampal sclerosis (2)
- histamine (2)
- histological validation (2)
- histone deacetylase (2)
- histone deacetylase inhibitor (2)
- homeostatic plasticity (2)
- hormones (2)
- human biology and medicine (2)
- human cytomegalovirus (2)
- human genomics (2)
- human immunodeficiency virus (2)
- human space flight (2)
- humans (2)
- hyperalgesia (2)
- hyperhomocysteinemia (2)
- hypertension (2)
- hypertrophy (2)
- iCBT (2)
- iDILI (2)
- iPS (2)
- idiopathic pulmonary fibrosis (2)
- immune therapy (2)
- immunocytochemistry (2)
- immunologische Methoden (2)
- in vitro model (2)
- in-cabin exposure (2)
- induced membrane (2)
- induction chemotherapy (2)
- infants (2)
- infections (2)
- infectious disease (2)
- infectivity (2)
- infiltration (2)
- influenza vaccination (2)
- inhibitor (2)
- inhibitors (2)
- injury (2)
- inner ear (2)
- insulin (2)
- integrate-and-fire (2)
- integrated stress response (2)
- integration (2)
- integrative medicine (2)
- interferon (2)
- interferon gamma (2)
- interleukin-18 (2)
- interleukin-4 (2)
- intermediate risk (2)
- international (2)
- internet (2)
- intervention trial (2)
- intracranial hemorrhage (2)
- irritable bowel syndrome (2)
- isolation (2)
- job-exposure matrix (2)
- joint contact forces (2)
- keratinized mucosa (2)
- kidney cancer (2)
- kidney function (2)
- kinase inhibitor (2)
- kinase regulation (2)
- kinematic analysis (2)
- kinematics (2)
- kinesin (2)
- klinischer Nutzen (2)
- knowledge discovery (2)
- laboratory testing (2)
- language (2)
- lapatinib (2)
- lathosterol (2)
- layer-specificity (2)
- learning (2)
- leisure time activity (2)
- lenalidomide (2)
- leukodystrophy (2)
- leukopenia (2)
- leukotriene (2)
- lifestyle intervention (2)
- lipolysis (2)
- lipoproteins (2)
- liposomes (2)
- liver damage (2)
- liver disease (2)
- liver metastases (2)
- local control (2)
- local fat reduction (2)
- local information dynamics (2)
- localized prostate cancer (2)
- lokale Fettabnahme (2)
- long-term outcome (2)
- long-term potentiation (2)
- long-term success (2)
- long-term survival (2)
- long-term tooth survival (2)
- longevity (2)
- loss (2)
- low density lipoproteins LDL (2)
- low molecular weight heparin (2)
- low-glycaemic meal replacement (2)
- lymph node dissection (2)
- lymphocytes (2)
- lysosomes (2)
- mHealth (2)
- mRNA stability (2)
- mTOR inhibitor (2)
- major depression (2)
- malaria (2)
- malignancy (2)
- malignant melanoma (2)
- mammary carcinoma (2)
- mandatory reporting (2)
- marginal bone loss (2)
- mast cells (2)
- mathematical models of viral RNA cycle (2)
- matrix (2)
- medical studies (2)
- medication review (2)
- medulloblastoma (2)
- melatonin (2)
- memantine (2)
- memory consolidation (2)
- mental health (2)
- mesenchymal stromal cell (2)
- metastatic castration-resistant prostate cancer (2)
- methylprednisolone (2)
- miR (2)
- miR-122 (2)
- miR-181 (2)
- miR-21 (2)
- microdosing (2)
- microenvironment (2)
- microscopy (2)
- microsurgery (2)
- microvesicles (2)
- mindfulness (2)
- minimalinvasive Biopsie (2)
- minimally invasive biopsies (2)
- mitophagy (2)
- mobile air quality study (2)
- modularity (2)
- molecular dynamics (2)
- molecular marker (2)
- molecular mimicry (2)
- molecular typing (2)
- monitoring (2)
- morphogenesis (2)
- morphometry (2)
- motor control (2)
- mouse models (2)
- mucormycetes (2)
- multicentre study (2)
- multidetector computed tomography (2)
- multinucleated giant cells (2)
- multiple trauma (2)
- muscle quality (2)
- musculoskeletal modeling (2)
- mutation (2)
- myelodysplastic syndrome (2)
- myocardial infarction (2)
- natural scenes (2)
- ncRNA (2)
- needlestick injury (2)
- neoadjuvante Chemotherapie (2)
- neoadjuvante Therapie (2)
- neocortical circuits (2)
- nephropathy (2)
- nerve injury (2)
- network analysis (2)
- network topology (2)
- neurobiology (2)
- neurocognitive (2)
- neurodegenerative diseases (2)
- neuroendocrine (2)
- neurogenesis (2)
- neuroinflammation (2)
- neuroinformatics (2)
- neuron (2)
- neuronal ceroid lipofuscinosis (2)
- neuronal populations (2)
- neurooncology (2)
- neuroprotection (2)
- neurosurgery (2)
- neuroticism (2)
- neutropenia (2)
- neutrophils (2)
- next generation sequencing (2)
- next generation sequencing (NGS) (2)
- niche (2)
- nivolumab (2)
- non-alcoholic fatty liver disease (2)
- non-alcoholic steatohepatitis (2)
- non-small cell lung cancer (2)
- non-small-cell lung cancer (2)
- non-structural proteins (2)
- nuclear receptor (2)
- nursery schools (2)
- nutlin-3 (2)
- occupational exposure (2)
- occupational health (2)
- olfaction (2)
- oligomerisation (2)
- omega-3 fatty acids (2)
- oncogene (2)
- oncogenes (2)
- oncomodulation (2)
- oral and maxillofacial surgery (2)
- osteogenesis (2)
- other-cause mortality (2)
- out-patient paediatrics (2)
- oxygen (2)
- p16 (2)
- pH (2)
- paclitaxel (2)
- pain management (2)
- paired associative stimulation (2)
- palatal tremor (2)
- pancreatic ductal adenocarcinoma (2)
- partial information decomposition (2)
- particle size distribution (2)
- passive smoke (2)
- pathology (2)
- patient (2)
- patient centered care (2)
- patient preferences (2)
- patient triage (2)
- patient-reported outcomes (2)
- pediatric surgery (2)
- pelvic packing (2)
- penile cancer (2)
- peptide aptamer (PA) (2)
- peri-implant diseases (2)
- pericytes (2)
- periodontal diseases (2)
- periodontitis stage III and IV (2)
- peri‐implantitis (2)
- personalized oncology (2)
- pertussis (2)
- phagocytes (2)
- pharmacoresistance (2)
- pharmacovigilance (2)
- phase separation (2)
- phenotype (2)
- phosphate (2)
- photoaging (2)
- photodynamic therapy (2)
- physical training (2)
- polo-like kinase 1 (2)
- poly(lactic-co-glycolic acid) (PLGA) (2)
- polygenic risk score (2)
- polymerase chain reaction (2)
- polymorphism (2)
- polyphenols (2)
- population dynamics (2)
- post-transcriptional regulation (2)
- post-translational modifications (2)
- postoperative complications (2)
- postoperative pain (2)
- preclinical (2)
- prediction (2)
- predictive (2)
- predictive factors (2)
- preterm birth (2)
- primary biliary cholangitis (2)
- primary motor cortex (2)
- prior knowledge (2)
- process evaluation (2)
- prognostic (2)
- prognostic value (2)
- progranulin (2)
- prostaglandin E (2)
- prostate carcinoma cells (2)
- proteasome inhibitor (2)
- protein kinase (2)
- protein phosphorylation (2)
- protein turnover (2)
- protein-rich (2)
- proteolysis (2)
- proteolysis systems (2)
- proto-oncogene proteins c-akt (2)
- proximal tubule (2)
- psychiatric disorders (2)
- psychiatry (2)
- psychosis (2)
- pulmonary embolism (2)
- pulmonary hypertension (2)
- pulmonary vein isolation (2)
- pulse wave velocity (2)
- qRT-PCR (2)
- quality (2)
- quality control (2)
- quality management (2)
- quantum biology (2)
- radical cystectomy (2)
- radioimmunotherapy (2)
- randomised controlled study (2)
- randomisierte kontrollierte Studie (2)
- randomized (2)
- randomized controlled trial (2)
- rare disease (2)
- rare diseases (2)
- rat model (2)
- re-osseointegration (2)
- real-world (2)
- real-world data (2)
- recommendations (2)
- reference values (2)
- refractory (2)
- refugees (2)
- regenerative medicine (2)
- regulatory T cell (2)
- renal failure (2)
- renal tubular epithelial cells (2)
- research (2)
- residual myometrial thickness (2)
- resistance training (2)
- resistant cell lines (2)
- resolution of inflammation (2)
- respiratory chain (2)
- respiratory failure (2)
- respiratory infections (2)
- respiratory tract infection (2)
- response inhibition (2)
- resting-state (2)
- review (2)
- revision surgery (2)
- rhodopsin (2)
- ribavirin (2)
- risk assessment (2)
- risk group (2)
- risk management (2)
- risk prediction (2)
- robotics (2)
- running (2)
- saliva (2)
- sarcoma (2)
- scaffold (2)
- school-based prevention (2)
- scientometry (2)
- second-hand smoke (2)
- second-line (2)
- secondary data analysis (2)
- secretion (2)
- secukinumab (2)
- selection (2)
- sensory neurons (2)
- sensory neuropathy (2)
- serine protease (NS3-4A) (2)
- serology (2)
- shunt (2)
- siRNA (2)
- signal transducer and activator of transcription 5 (Stat5) (2)
- signature (2)
- single-sided deafness (2)
- sitosterol (2)
- skin (2)
- skin infection model (2)
- sleep quality (2)
- smoking cessation (2)
- smooth muscle cells (2)
- soft tissue (2)
- soluble MICA (2)
- soluble epoxide hydrolase (2)
- somatic mutations (2)
- sound-induced flash illusion (2)
- space adaptations (2)
- spectroscopy (2)
- speech (2)
- speech and language disorder (2)
- speech perception (2)
- sphingosine 1-phosphate receptor (2)
- spiking neural networks (2)
- spinal dural leaks (2)
- spine head (2)
- sports nutrition (2)
- spreadsheet (2)
- stability (2)
- stage (2)
- standard value (2)
- standardization (2)
- starvation (2)
- stationarity (2)
- steatosis (2)
- stem cell therapy (2)
- stem cells (2)
- stereotactic radiosurgery (2)
- stimulus encoding (2)
- stress granules (2)
- structural biology (2)
- studies (2)
- study protocol (2)
- sub-lineage (2)
- subchondral bone (2)
- suicide (2)
- superficial siderosis (2)
- supersaturation (2)
- supplementation (2)
- supportive therapy (2)
- survival rate (2)
- survivin (2)
- sympathetic nervous system (2)
- symptoms (2)
- synapse (2)
- synaptopodin (2)
- synchronization (2)
- synovium (2)
- tDCS (2)
- telemedicine (2)
- temsirolimus (2)
- terminology (2)
- test methods (2)
- testing (2)
- testosterone (2)
- tetracycline (2)
- tetrahydrobiopterin (2)
- tetrahydrocannabinol (2)
- tetrapolar bioimpedance analysis (2)
- tetrapolare Bioimpedanzanalyse (2)
- therapy resistance (2)
- thromboembolism (2)
- thrombophilia (2)
- thromboxane (2)
- time-lapse imaging (2)
- tissue Doppler imaging (2)
- tobacco (2)
- tobacco smoke (2)
- tolerability (2)
- tolerance (2)
- tomosynthesis (2)
- tooth transplantation (2)
- total hip replacement (2)
- tracking (2)
- traffic emissions (2)
- training program (2)
- transcription factors (2)
- transcriptomics (2)
- transforming growth factor-β (2)
- translation (2)
- trastuzumab (2)
- treatment outcome (2)
- treatment preference (2)
- treatment/therapy (2)
- triple-negative breast cancer (2)
- trophoblast (2)
- trophoblasts (2)
- tumor (2)
- tumor infiltrating lymphocytes (2)
- tumor necrosis factor (2)
- tumor stroma (2)
- tumor suppressor (2)
- tumor-infiltrating lymphocytes (2)
- type 2 diabetes (2)
- undergraduate medical education (2)
- unilateral hip osteoarthritis (2)
- unsupervised learning (2)
- upgrading (2)
- urethral stricture (2)
- urethroplasty (2)
- urinary incontinence (2)
- urological cancer (2)
- ursodeoxycholic acid (2)
- ustekinumab (2)
- uteroglobin (2)
- vaccination rates (2)
- vaccine uptake rates (2)
- vascular biology (2)
- vascular disease (2)
- vasodilation (2)
- venous thrombosis (2)
- ventral striatum (2)
- vergence (2)
- vertebroplasty (2)
- very high risk (2)
- virology (2)
- virulence factor (2)
- viruses (2)
- vision (2)
- visual system (2)
- vitamin B deficiency (2)
- von Willebrand disease (2)
- wIRA (2)
- waiting time (2)
- warts (2)
- weight loss (2)
- white matter hyperintensity (2)
- within-host viral modelling (2)
- women (2)
- workflow (2)
- xenograft (2)
- yeast (2)
- yellow flags (2)
- zebrafish (2)
- Ärztliche Aufklärung (2)
- Ökonomie (2)
- Übergewicht (2)
- 创伤后应激障碍 (2)
- "NS"-Euthanasie (1)
- "alternative" technology (1)
- "conventional" analysis technics (1)
- (cardiac) surgery (1)
- (lyso)phospholipids (1)
- (novel) brominated flame retardants ((N)BFR) (1)
- (sub-) luxation (1)
- 1,2-dichloroethane (1)
- 1,25-Dihydroxyvitamin D (1)
- 1-propanol (1)
- 10-Hydroxyaloins A/B (1)
- 11q23/MLL rearrangements (1)
- 11th September (1)
- 14-3-3 gene family (1)
- 15-PGDH (1)
- 15. Jahrhundert (1)
- 16 segment AHA model (1)
- 16S rRNA sequencing (1)
- 16p11.2 (1)
- 177Lu-PSMA (1)
- 17‐OH itraconazole (1)
- 18-Hydroxycorticosteron (1)
- 18-OH corticosterone (1)
- 19F MR spectroscopy (1)
- 1H MR spectroscopy (1)
- 1α,25(OH)2D3 (1)
- 2'-deoxyguanosine riboswitch (1)
- 2-AG (1)
- 2-Arachidonoyl glycerol (1)
- 2-deoxy-d-glucose (1)
- 2-deoxyglucose (2-DG) (1)
- 2-hydroxyglutarate (1)
- 2019-nCoV (1)
- 223Radium-dichloride (1)
- 26 LncRNA (1)
- 2D NMR spectroscopy (1)
- 2‑methoxyestradiol (1)
- 2′,3′-cGAMP (1)
- 2′-O-methylation (1)
- 3 mm RAS instruments (1)
- 3 mm instruments (1)
- 3,4-DCA; biotransformation (1)
- 3-hydroxyanthranilic acid (1)
- 3-hydroxyisovaleryl carnitine (1)
- 3-year survival (1)
- 32D progenitor cells (1)
- 3C protease(3Cpro) (1)
- 3Cs technology (1)
- 3D cell culture (1)
- 3D culture (1)
- 3D gait analysis (1)
- 3D image analysis (1)
- 3D laparoscopy (1)
- 3D modeling (1)
- 3D printed cell-free scaffold (1)
- 3D printing using composite resin (1)
- 3D printing using zirconia (1)
- 3D spatiotemporal resolved mathematical models (1)
- 3D tissue models (1)
- 3D-Druck (1)
- 3D-models (1)
- 3D-printing (1)
- 3T3-L1 mouse fibroblasts (1)
- 3years (1)
- 4-1BB (1)
- 4-FA (1)
- 4-fluoroamphetamine (1)
- 5 lipoxygenase (1)
- 5' UTR (1)
- 5-Aminolävulinsäure (5-ALA) (1)
- 5-Lipoxygenase (1)
- 5-Lipoxygenase activating protein (FLAP) (1)
- 5-aminolevulinic acid (5-ALA) (1)
- 5_SL4 (1)
- 6-Schritt-Methode (1)
- 9-HODE (1)
- 90% or more improvement in baseline Psoriasis Area and Severity Index (1)
- 98/79/EC (1)
- 99mTc-MIBI (1)
- 99mTc-pertechnetate (1)
- A-FFIP (1)
- A-PRF+ (1)
- A2BP1 (1)
- A375 human melanoma cell line (1)
- A375 human melanoma cells (1)
- A498 cells (1)
- A549 (1)
- AA-amylodosis (1)
- AAA+ disaggregase (1)
- AABR (1)
- AB-serum (1)
- ABC transporter (1)
- ABC transporters (1)
- ABCB5 (1)
- ABS (1)
- ABT-737 (1)
- ACAD (1)
- ACE inhibitor (1)
- ACE-Bestimmung (1)
- ACE-inhibitor (1)
- ACI-Rat (1)
- ACI-Ratte (1)
- ACKR (1)
- ACT-777991 (1)
- ACTH (1)
- ACURATE neo (1)
- ADAM-17 (1)
- ADAM10 (1)
- ADAMTS-13 (1)
- ADAMTS13 (1)
- ADAR (1)
- ADC (1)
- ADC-Karte (1)
- ADC-Map (1)
- ADCC (1)
- ADGRE1 (1)
- ADHD differential diagnosis (1)
- AEC syndrome (1)
- AF4–MLL (1)
- AFS (1)
- AGC kinase (1)
- AGMO (1)
- AICAR (1)
- AIH immunopathogenesis (1)
- AIS (1)
- AKT signaling (1)
- AKT-mTOR pathway (1)
- ALD (1)
- ALDH2 (1)
- ALF (1)
- ALK gene (1)
- ALK-rearranged NSCLC (1)
- ALLO (1)
- AMD3100 (1)
- AML – acute myeloid leukemia (1)
- AMP-activated kinase (1)
- AMP-activated kinase (AMPK) (1)
- AO-PCCF (1)
- AOSpine (1)
- AOSpine injury score (1)
- API (1)
- APM (1)
- APMPPE - acute posterior multifocal placoid pigment epitheliopathy (1)
- APP (1)
- APRI (1)
- APS (1)
- APT-CEST (1)
- ARA (1)
- ARID5B (1)
- ASA (1)
- ASA-Klassifikation (1)
- ASA404 (1)
- ASAP (1)
- ASC (1)
- ASCT (1)
- ASD-specific (1)
- ASO (1)
- ASPECTS (1)
- AT-101 (1)
- AT1 receptor antagonist (1)
- ATAD2 (1)
- ATG3 (1)
- ATO (1)
- ATP binding (1)
- ATP synthase (1)
- ATPases (1)
- ATXN2 (1)
- AU-rich element (1)
- AVM hemorrhage (1)
- AZD7762 (1)
- Aachen <2012> (1)
- Abatacept (1)
- Abdominal infections (1)
- Abdominal surgery (1)
- Abdominal trauma (1)
- Abductor pollicis longus (1)
- Abiraterone acetate (1)
- Abl kinase inhibitors (1)
- Ablation (1)
- Ablation Techniques (1)
- Abnahme einer Hypersekretion (1)
- Abnahme vermehrter Speichelbildung (1)
- Abnahme von Schleimbildung (1)
- Abrasion (1)
- Abruf (1)
- Absenteeism (1)
- Absolute quantification (1)
- Absorption modeling (1)
- Abstrich <Medizin> (1)
- Abstrichisolate (1)
- Abtötung (1)
- Abtötungskinetik (1)
- Abusive head trauma (AHT) (1)
- Abweichungen (1)
- Academic health centres (1)
- Academics (1)
- Accelerometry (1)
- Accessibility (1)
- Accessory olfactory system (1)
- Access® immunoassay system (1)
- Access®-Immunoassaysystem (1)
- Accident (1)
- Accidents (1)
- Accumulated degree days (1)
- Acellular dermis (1)
- Acenocoumarol (1)
- Acer platanoides (1)
- Acetabulumdefekt (1)
- Acetylsalicylsäure (1)
- Achtundsechzig (1)
- Achtundsechziger (1)
- Acid ceramiase (1)
- Acide gamma-aminobutyrique (1)
- Acidic Dissociation (1)
- Acoustic signals (1)
- Acquired drug resistance (1)
- Acquired resistance (1)
- Acrylamid (1)
- Actaea cimicifuga (1)
- Actin (1)
- Actinomycin D (1)
- Action Plan for Medication Safety (1)
- Action potential (1)
- Activated partial thromboplastin time (1)
- Active middle ear implants (1)
- Activin (1)
- Activity control (1)
- Acupuncture (1)
- Acute (1)
- Acute HIV infection (1)
- Acute Hemiparesis (1)
- Acute Myeloid Leukemia (1)
- Acute Promyelocytic Leukemia (1)
- Acute appendicitis (1)
- Acute bronchitis (1)
- Acute calcolous cholecystitis (1)
- Acute coronary syndrome (1)
- Acute cough (1)
- Acute elbow dislocation (1)
- Acute heart failure (1)
- Acute hospital (1)
- Acute injuries (1)
- Acute kidney failure (1)
- Acute leukemia, chromosomal translocation, MLL, KMT2A, AF4-MLL, reciprocal fusion protein, MLL-r leukemia, (1)
- Acute renal failure (1)
- Acute respiratory distress syndrom (1)
- Acute-on-chronic subdural hematoma (1)
- Adaptationsfähigkeit (1)
- Adaptive immunity (1)
- Adaptive process control (1)
- Adeno associated virus (1)
- Adenosine (1)
- Adenosine A1 receptor (1)
- Adenylyl cyclase (1)
- Aderlass (1)
- Adhesins (1)
- Adhesion Factor (1)
- Adhärenz (1)
- Adipose tissue-derived mesenchymal stem cells (1)
- Adipositas (1)
- Adipositas Chirurgie (1)
- Adiposity (1)
- Adjustment of dosage at steady state (1)
- Adjuvant procedure (1)
- Adjuvant therapies (1)
- Adjuvante Therapie (1)
- Adjuvantes Verfahren (1)
- Administrative claims data (1)
- Adoptive Immuntherapie (1)
- Adrenal crisis (1)
- Adrenale Krise (1)
- Adrenalektomie (1)
- Adrenocorticotropic hormone (1)
- Adrenokortikotropes Hormon (1)
- Adult (1)
- Adult T-cell acute lymphoblastic leukemia (1)
- Adult-onset ADHD (1)
- Advanced biliary tract cancer (1)
- Advanced breast cancer (1)
- Advanced glycation endproducts (1)
- Advanced stage (1)
- Adverse effects (1)
- Aedes aegypti (1)
- Aedes albopictus (1)
- Aerobic exercise training (1)
- Aeroplysinin-1 (1)
- Aerosolspektrometrie (1)
- Aesthetics (1)
- Affect (1)
- Affective Misattribution Procedure (1)
- Affective disorders (1)
- Afrikanische Schlafkrankheit (1)
- Ag-RDT (1)
- Aganglionosis (1)
- Agardiffusion (1)
- Age determination (1)
- Age determination by skeleton (1)
- Age-structure (1)
- Ageing (1)
- Aggregation (1)
- Aggressive periodontitis (1)
- Agitation (1)
- Agoraphobia (1)
- Agreement (1)
- Aikido (1)
- Air traffic (1)
- Airport-related emissions (1)
- Airways (1)
- Akkreditierung (1)
- Akt-mTOR pathway (1)
- Akt-mTOR signaling (1)
- Aktive Zone (1)
- Aktivierte partielle Thromboplastinzeit (1)
- Aktivität (1)
- Akupressur (1)
- Akupunktur (1)
- Akute (1)
- Akute Leukämie (1)
- Akute Lymphatische Leukämie (1)
- Akute Niereninsuffizienz (1)
- Akute Verletzungen (1)
- Akute lymphoblastische Leukämie (1)
- Akutes Koronarsyndrom (1)
- Akutmedizin (1)
- Akzelerationszeit (1)
- Albumin (1)
- Albumin ratio (1)
- Alignment <Biochemie> (1)
- Aliphatic halogenated hydrocarbons (1)
- Alisertib (1)
- Alkaline phosphatase (1)
- Alkalische Phosphatase (1)
- Alkaloid (1)
- Alkohol (1)
- Alkoholiker (1)
- Alkoholismus (1)
- Alkoholmissbrauch (1)
- All oral (1)
- All-oral therapy (1)
- All-trans retinoic acid (1)
- Allergen (1)
- Allergen immunotherapy (1)
- Allergen-Testung (1)
- Allergenprovokation (1)
- Allergic rhinitis (1)
- Allergische Rhinitis (1)
- Allergisches Asthma (1)
- Allergoid (1)
- Allgemeinmedizin Forschung (1)
- Allogeneic (1)
- Allogeneic Stem Cell Transplantation (SCT) (1)
- Allogeneic hematopoietic stem (1)
- Allogeneic stem cell transplantation (1)
- Allograft bone block (1)
- Allokation der Ressourcen (1)
- Allopregnanolon (1)
- Alpha oscillations (1)
- Alpha power (1)
- Alpha rhythm (1)
- Alpha-V integrin (1)
- Alpha-fetoprotein (AFP) (1)
- Alpha-synuclein deficiency (1)
- Alphavirus (1)
- Alte Medizin (1)
- Altenheim (1)
- Altern (1)
- Alternative oxidase (1)
- Alternative splicing (1)
- Alterung (1)
- Altitude training (1)
- Alveolar macrophages (1)
- Alveolar ridge augmentation (1)
- Alzheimer’s dementia (1)
- Ambient air (1)
- Ambroxol (1)
- Ambulante Pflege (1)
- Ambulatory Assessment (1)
- Ameloblastoma (1)
- American Football (1)
- Amino acid analysis (1)
- Amino acids (1)
- Aminosäuremetabolismus (1)
- Aminosäuren (1)
- Aminotransferases (1)
- Amiodaron (1)
- Amisulpride (1)
- Amitriptyline (1)
- Amizon (1)
- Amniotic fluid (1)
- Amphetamine (1)
- Amsterdam-Kriterien (1)
- Amygdala (1)
- Amyloid precursor protein (1)
- Amyloid-beta (1)
- Amyloid-beta 42 (1)
- Amyotrophic lateral sclerosis (1)
- Anabolism (1)
- Anaesthesia (1)
- Anakinra (1)
- Analkarzinom (1)
- Analschleimhautabstrich (1)
- Analysis tool (1)
- Anamneseerhebung (1)
- Anaplastic astrocytoma (1)
- Anatomic competence (1)
- Anatomie (1)
- Anatomie und Histologie (1)
- Andersen-Tawil syndrome (1)
- Anderson–Fabry (1)
- Andexanet alpha (1)
- Andropogon virginicus (1)
- Anemia management (1)
- Anerkennung (1)
- Anesthesia, Intravenous (1)
- Aneurysm (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Aneurysms (1)
- Anfall (1)
- Anfallsserie (1)
- Anfallsunterbrechende (1)
- Anfallsunterbrechende Medikamente (1)
- Angeborene Fehlbildungen (1)
- Angiectasia (1)
- Angiodysplasia (1)
- Angioedema (1)
- Angiogenèse (1)
- Angiomyolipoma (1)
- Angioplasty (1)
- Angiotensin Converting Enzyme (1)
- Angiotensin-converting enzyme (1)
- Angststörungen (1)
- Animal disease models (1)
- Animal experiment (1)
- Animal wings (1)
- Anisakidae, Pseudoterranova decipiens Komplex, Transkriptom, Verbreitung, Zoonose (1)
- Anisotrope Diffusion (1)
- Ankle arthrometer (1)
- Ankylosierende Spondylitis (1)
- Ankylosing spondylitis (1)
- Anomalie <Medizin> (1)
- Anomalous venous atrial connections (1)
- Anopheles (1)
- Anorexia Nervosa (1)
- Anosmia (1)
- Anpassung (1)
- Antagonist (1)
- Antarctic parasites (1)
- Anterior cingulate cortex (1)
- Anterior cruciate ligament reconstruction (1)
- Anthranoids (1)
- Anthropologie (1)
- Anti platelet therapy (1)
- Anti-CMV IgG (1)
- Anti-Cardiolipin-Antikörper (1)
- Anti-Müller-Hormon (1)
- Anti-Phospholipid-Syndrom (1)
- Anti-TNF (1)
- Anti-inflammatory (1)
- Anti-rheumatic agents (1)
- Anti-tumor immunity (1)
- Anti-viral activity (1)
- Antiangiogenesis (1)
- Antibiotic (1)
- Antibiotic generic drugs (1)
- Antibiotic steward-ship (1)
- Antibiotic stewardship (1)
- Antibiotic therapy (1)
- Antibiotika (1)
- Antibiotikaresistenz (1)
- Antibody avidity (1)
- Antibody detection (1)
- Antibody isotypes (1)
- Antibody therapy (1)
- Antibody-mediated rejection (1)
- Anticancer therapy (1)
- Anticholinergic (1)
- Anticoagulant (1)
- Anticoagulants (1)
- Anticoagulants [MeSH] (1)
- Anticonvulsant (1)
- Anticonvulsant activity (1)
- Antidepressant (1)
- Antidepressiva (1)
- Antifungal agents (1)
- Antigen (1)
- Antigen CD62 (1)
- Antigen processing and presentation (1)
- Antigen- und Nukleinsäurenachweis (1)
- Antigen-presenting cells (1)
- Antigene Virale/Immunologie (1)
- Antigennachweis (1)
- Antigens (1)
- Antigens,Viral/immunology (1)
- Antigens/Peptides/Epitopes (1)
- Antihormone therapy (1)
- Antike (1)
- Antikörpernachweis (1)
- Antineoplastic agents (1)
- Antioxidant (1)
- Antioxidants (1)
- Antiplatelet therapy (1)
- Antiproliferative (1)
- Antireflux surgery (1)
- Antirheumatic agents (1)
- Antiseizure medication (1)
- Antiseizure medication Instructions for action (1)
- Antisense-Oligonucleotide (1)
- Antithrombotic therapy (1)
- Antivenom (1)
- Antiviral agents (1)
- Antiviral immune response (1)
- Antiviral response (1)
- Antiviral treatment (1)
- Antivirale Therapie (1)
- Anwendbarkeit (1)
- Anxiolytic pharmacological therapy (1)
- Anzapfsyndrom (1)
- Aortic Valve Replacement (1)
- Aortic aneurysm (1)
- Aortic arch replacement (1)
- Aortic debranching (1)
- Aortic input function (1)
- Aortic stiffness (1)
- Aortic valve sparing (1)
- Aperiodic (1)
- Apes (1)
- Aphantasia (1)
- Aphasia (1)
- Aphasie (1)
- Apoptose (1)
- Apoptotic cell death (1)
- Appendicitis (1)
- Appendizitis (1)
- Aquaporins (1)
- Aquilegia (1)
- Ara h2-specific IgE (1)
- Arabin pessary (1)
- Arabin-Pessar (1)
- Arachidonic acid cascade (1)
- Arbeit (1)
- Arbeitsbedingt erworbene Infektion (1)
- Arbeitsbedingungen (1)
- Arbeitsflexibilisierung (1)
- Arbeitsmedizin (1)
- Arbeitsplatzkonflikt (1)
- Arboviruses (1)
- Arc protein (1)
- ArchT (1)
- Archaeology (1)
- Archery (1)
- Architektur (1)
- Arcuate fascicle (1)
- Area deprivation (1)
- Argatroban (1)
- Arms (1)
- Aromatase Inhibitors (1)
- Aromatase inhibitors (1)
- Arrhythmia syndromes (1)
- Arrhythmia/all (1)
- Arrow (1)
- Artemether-lumefantrine (1)
- Artemisinin-combination-therapy (1)
- Arteria ophthalmica (1)
- Arterielle Thrombose (1)
- Arterielle Verschlusskrankheit (1)
- Arteriogenesis (1)
- Arteriosclerosis (1)
- Arteriovenous malformation (1)
- Artesunate (1)
- Arthrodese (1)
- Arthroscopy (1)
- Arthroskopischer Bankart-Repair (1)
- Artificial feeding bioassays (1)
- Artificial neural networks (1)
- Arznei- und Heilmittelrichtlinie (1)
- Arzneimitteldesign (1)
- Arzneimittelrecht (1)
- Arzt (1)
- Arzt-Patient-Beziehung (1)
- Asparaginase (1)
- Aspergillosis (1)
- Aspergillus species (1)
- Aspirin (1)
- Assay variation (1)
- Assessment of care (1)
- Asthma and allergic disorders (1)
- Asthmadiagnostik (1)
- Astrocytoma (1)
- Astrocytoma grades (1)
- Astrozyt (1)
- Astrozyten (1)
- Ataxia score (1)
- Atazanavir (1)
- Atemtest (1)
- Atención centrada en el paciente (1)
- Athena SWAN (1)
- Atherosklerose (1)
- Athlete (1)
- Athletes (1)
- Atm (1)
- Atomic force microscopy (1)
- Atomoxetine (1)
- Atrial Fibrillation (1)
- Atrial appendage occlusion (1)
- Atrial fibrillation classification (1)
- Atrial function (1)
- Attack (1)
- Attention Deficit Hyperactivity Disorder (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Attention deficit (1)
- Attention-Deficit/Hyperactivity Disorder (ADHD) (1)
- Attention-deficit / hyperactivity disorder (1)
- Attentional bias (1)
- Attentional set (1)
- Attrition (1)
- Atxn2 (1)
- Audio equipment (1)
- Audiologie (1)
- Audiology (1)
- Audition (1)
- Auditory (1)
- Auditory cortex (1)
- Auditory midbrain (1)
- Aufmerksamkeit (1)
- Aufmerksamkeits-und-hyperaktivitätsstörung (1)
- Aufmerksamkeitsleistung (1)
- Aufsatzsammlung (1)
- Augenarzt (1)
- Augenchirurgie (1)
- Augenerkrankungen (1)
- Augenverletzungen (1)
- Auric nanoparticles (1)
- Aurora (1)
- Aurora Ax (1)
- Aurora kinase inhibitor (1)
- Ausbildung (1)
- Ausdauertraining (1)
- Australia (1)
- Authoritarianism (1)
- Autism Spectrum disorder (1)
- Autism spectrum disorders (1)
- Autismus-Spektrum-Störungen (1)
- Autistic Behavior (1)
- Autistic disorder (1)
- Auto transfusion (1)
- Autobiografie (1)
- Autobiography (1)
- Autogenous bone block (1)
- Autoimmun (1)
- Autoimmune Disease (1)
- Autoimmune encephalomyelitis (1)
- Autoimmune response (1)
- Autoimmune vasculopathy (1)
- Autoimmunität (1)
- Autologous stem cell transplantation (1)
- Automated Tube Potential Selection (1)
- Automatic Environmental Tobacco Smoke Emitter (1)
- Automatic prediction (1)
- Automatisation (1)
- Autonomes Nervensystem (1)
- Autonomic nervous system (1)
- Autophagie (1)
- Autoregulation (1)
- Autosomal recessive cutis laxa type 1C (1)
- Awareness (1)
- Awareness campaign (1)
- Axial spondyloarthritis (1)
- Axiale Spondyloarthritis (1)
- Axiales Längenwachstum (1)
- Axiography (1)
- Axon (1)
- Ayahuasca (1)
- Ayurvedic herbal products (1)
- Azacitidine (1)
- Azan (1)
- Azan trichrome stain (1)
- Azathioprin (1)
- Azathioprine (1)
- Azidothymidine (1)
- B cell cancer (1)
- B cell differentiation (1)
- B cell malignancies (1)
- B cell precursor acute lymphoblastic leukemia (1)
- B cell receptor (1)
- B cell subpopulations (1)
- B-cell (1)
- B-cell antigen receptor (1)
- B-cell immunology (1)
- B-cell non-Hodgkin lymphoma (1)
- B-cell receptor (1)
- B-cell transcription factors (1)
- B.1.1.529 (1)
- B.1.1.7 (1)
- B.1.617.1 (1)
- B.1.617.2 (1)
- B16 cells (1)
- B3GNT2 (1)
- BA.4 (1)
- BA.5 (1)
- BACTEC™ 9000 (1)
- BATF3 (1)
- BBB (1)
- BCG (1)
- BCG-Therapie (1)
- BCL-2 (1)
- BCL11b (1)
- BCORL1 (1)
- BCR signaling (1)
- BCR-ABL (1)
- BEACOPP (1)
- BET inhibitor (1)
- BET inhibitors (1)
- BET proteins (1)
- BEZ235 (1)
- BFIS (1)
- BFR (1)
- BG-index (1)
- BH3 mimetics (1)
- BH4 (1)
- BI1361849 (1)
- BIAM switch assay (1)
- BIAM-switch (1)
- BIRC5 (1)
- BK channel (1)
- BMAC (1)
- BMP4 (1)
- BMSC (1)
- BNC2 (1)
- BNT2b2 (1)
- BOPTA (1)
- BPD (1)
- BPDCN (1)
- BPO (1)
- BPTF (1)
- BRAF V600E (1)
- BRAF inhibitors (1)
- BRAF mutation (1)
- BRD2 (1)
- BRD4-NUT (1)
- BRD7 (1)
- BRG1 (1)
- BROMO-10 (1)
- BRUCE (1)
- BRVO (1)
- BSP (1)
- BTC (1)
- BTK (1)
- BV6 (1)
- Babesia venatorum (1)
- Baby-Bodyplethysmographie (1)
- Bacillus subtilis (1)
- Back scan (1)
- Backpropagating action potential (1)
- Bacteraemia (1)
- Bacteremia/diagnosis (1)
- Bacteria-host interaction (1)
- Bacterial Chromosome (1)
- Bacterial Protein Kinases (1)
- Bacterial Protein Phosphatases (1)
- Bacterial abundance (1)
- Bacterial adhesion (1)
- Bacterial biofilm (1)
- Bacterial intestinal overgrowth (1)
- Bacterial leakage (1)
- Bacterial pathogenesis (1)
- Bacterial pathogens (1)
- Bacterial structural biology (1)
- Bacteriological techniques (1)
- Bad (1)
- BadA, (1)
- Bag6 (1)
- Bagatelltrauma (1)
- Bakterien (1)
- Bakterientest (1)
- Bakteriologische Techniken (1)
- Bakterizidie Index (1)
- Bakteriämie/Diagnostik (1)
- Ballet (1)
- Ballon (1)
- Ballon-assisted enteroscopy (1)
- Balloon-expandable TAVI (1)
- Balneologie (1)
- Bamlanivimab (1)
- Bandpass filters (1)
- Bankart-Läsion (1)
- Bariatric surgery (1)
- Barlow disease (1)
- Barrier (1)
- Bartonella (1)
- Bartonella adhesin A (1)
- Bartonella grahamii (1)
- Bartonella schoenbuchensis (1)
- Basal Ganglia (1)
- Basal ganglia (1)
- Basalzellkarzinom (1)
- Basedow-Krankheit (1)
- Basel Consensus Statement (1)
- Basler Consensus Statement (1)
- Bassoon (1)
- Bayesian inference (1)
- Bayesian model (1)
- Bcl-2 (1)
- Bcr-Abl (1)
- Beatmung (1)
- Beckenschiefstand (1)
- Beckwith–Wiedemann syndrome (1)
- Becton Dickinson (1)
- Bedburg-Hau, Anstalt (1)
- Bee venom allergy (1)
- Befinden (1)
- Befindlichkeit (1)
- Beginners (1)
- Begriffsbestimmung (1)
- Behandlungskontrolle (1)
- Behandlungspfad (1)
- Behandlungssystematik (1)
- Behandlungsumfang (1)
- Behavioral analysis (1)
- Behavioral experiment (1)
- Behavioral tests (1)
- Behavioural ecology (1)
- Behinderung (1)
- Belastung (1)
- Bence Jones (BJ) proteinuria (1)
- Bence Jones-Proteinurie (1)
- Benchmarks (1)
- Benign disorder (1)
- Benign enlargement of the subarachnoid spaces (BESS) (1)
- Benign prostatic hyperplasia (1)
- Benign pulmonary diseases (1)
- Benigne Lungenerkrankungen (1)
- Bentall operation (1)
- Beratung (1)
- Berci needle (1)
- Bereavement (1)
- Berner, Friedrich (1)
- Bernhard Waldenfels (1)
- Bernštejn, Nikolaj A. (1)
- Berotralstat (1)
- Berufliche Gesundheit (1)
- Berufszufriedenheit (1)
- Beschneidung <Frau> (1)
- Beschreibung (1)
- Beschäftigte (1)
- Besessenheit (1)
- Besiedelungsgrad (1)
- Best practice (1)
- Best-practice model (1)
- Bestimmungsmethoden (1)
- Bestrahlung (1)
- Betazellfunktion (1)
- Betriebliches Wiedereingliederungsmanagement (1)
- Beurteilungen (1)
- Bevölkerungsschutz (1)
- Bewegungsanalyse mit Inertialsensoren (1)
- Bewegungserziehung (1)
- Bewegungsphysiologie (1)
- Bewegungssteuerung (1)
- Bewegungsstörung (1)
- Bewertungen (1)
- Bewältigung (1)
- Bezeichnungen (1)
- Bias (1)
- Bibliometric analysis (1)
- Bidirectional genes (1)
- Big data (1)
- Big five (1)
- Biglycan (1)
- Bilateral cochlear implant (1)
- Bilateral sagittal split osteotomy (1)
- Bildgebendes Verfahren (1)
- Bildnis (1)
- Bildqualität (1)
- Bildung (1)
- Bildverarbeitung (1)
- Biliary physiology (1)
- Biliary tree (1)
- Biliary tree stones (1)
- Bilirubin (1)
- Bilirubinbestimmung (1)
- Billroth II gastroenterostomy (1)
- Billroth papillotome (1)
- Billroth’s operation-II (1)
- Bilobalid (1)
- Bilobalide (1)
- Binding analysis (1)
- Binocular Rivalry (1)
- Bio safety (1)
- BioCreative V.5 (1)
- BioID (1)
- BioNLP (1)
- Bioactivity-guided fractionation (1)
- Bioavailability (1)
- Bioavailability prediction (1)
- Bioelektrische Impedanzanalyse (1)
- Bioequivalence (1)
- Biofluids (1)
- Bioinformatik (1)
- Biological (1)
- Biological heart valves (1)
- Biological markers (1)
- Biological neural networks (1)
- Biological psychiatry (1)
- Biological sciences (1)
- Biological techniques (1)
- Biologisches Profil (1)
- Biomarker Discovery Study (1)
- Biomarker Lipoprotein(a) (1)
- Biomarker TIMP‑2 und IGFBP7 (1)
- Biomarkers & Diagnostic Imaging (1)
- Biomarkers TIMP‑2 and IGFBP7 (1)
- Biomechanical analysis (1)
- Biomedical named entity recognition (1)
- Bioprosthesis (1)
- Biopsychosocial (1)
- Biopsychosocial model (1)
- Biopsychosoziales Krankheitsmodell (1)
- Biopterin (1)
- Biotechnology (1)
- Biowaiver (1)
- Bipolare Störung (1)
- Biposiekomplikationen (1)
- Birds (1)
- Birkenpollen (1)
- Birth (1)
- Bisphosphonates (1)
- Black cohosh (1)
- Black cohosh induced liver injury (1)
- Blasenkarzinom (1)
- Bleeding Risk (1)
- Blended learning curriculum · (1)
- Blended-Learning-Curriculum (1)
- Blended-learning (1)
- Bletilla striata (1)
- Blinatumomab (1)
- Blindness (1)
- Blockbuch (1)
- Blocked occlusion (1)
- Blood Banks/standards (1)
- Blood Transfusion, Autologous (1)
- Blood brain barrier (1)
- Blood cells (1)
- Blood coagulation disorder (1)
- Blood flow (1)
- Blood flow restriction (1)
- Blood loss calculator (1)
- Blood loss formula (1)
- Blood management (1)
- Blood parameters (1)
- Blood sample handling (1)
- Blood sampling (1)
- Blood transfusion (1)
- Bloodstream infection (1)
- Blot, Western (1)
- Blot, western (1)
- Blow fly (1)
- Blowflies (1)
- BluePrint (1)
- Blurred vision (1)
- Blut- und Plasmaprodukte (1)
- Blutbanken/Standards (1)
- Blutflussrestriktion (1)
- Blutflußumkehr (1)
- Blutgefäß (1)
- Blutgerinnungshemmung (1)
- Blutkulturdiagnostik (1)
- Blutparameter (1)
- Blutspenderscreening (1)
- Blutstammzelle (1)
- Blutstammzelle ; Nabelschnur ; Antigen CD34 ; Zellkultur (1)
- Bluttransfusion, Autologe (1)
- Blutung (1)
- Blutungskontrolle (1)
- Bochum <2010> (1)
- Body image (1)
- Body limbs (1)
- Body measurements (1)
- Body sway (1)
- Body temperature (1)
- Body-contouring surgery (1)
- Bodyplethysmographie (1)
- Bold fmri (1)
- Bologna process (1)
- Bologna-Prozess (1)
- Bone (1)
- Bone and joint mechanics (1)
- Bone cancer (1)
- Bone cement implantation syndrome (1)
- Bone conduction devices (1)
- Bone diseases, Metabolic (1)
- Bone dust (1)
- Bone fracture (1)
- Bone marrow aspirate concentrate (1)
- Bone marrow cells (1)
- Bone marrow fibrosis (1)
- Bone marrow mononuclear cells (1)
- Bone metastasis (1)
- Bone remodelling (1)
- Bone strength assessment (1)
- Bone substitute (1)
- Bone tumor (1)
- Borrelia Garinii (1)
- Borrelia miyamotoi (1)
- Borrelien (1)
- Bortezomib (1)
- Boswellia serrata (1)
- Boswellic acids (1)
- Bottom-up (1)
- Bovine Spongiforme Enzephalopathie (BSE) (1)
- Bovine spongiform, encephalopathy (BSE) (1)
- Bow (1)
- Brachial artery (1)
- Brachytherapy (1)
- Bradycardia (1)
- Bradykinin (1)
- Brain DNA methylation (1)
- Brain anatomy (1)
- Brain asymmetry (1)
- Brain damage (1)
- Brain development (1)
- Brain imaging (1)
- Brain injuries (1)
- Brain injury (1)
- Brain ischemia (1)
- Brain lesion (1)
- Brain repair (1)
- Brain size I (1)
- Brain structure (1)
- Brain tumor surgery (1)
- Brain tumors (1)
- Brain-stimulus synchrony (1)
- BrainNet Europe consortium (1)
- Brazil (1)
- Breast Cancer (1)
- Breast cancer survivers (1)
- Breast conserving surgery (1)
- Breast neoplasm (1)
- Breast reconstruction (1)
- Breath testing (1)
- Breathing (1)
- Breech delivery (1)
- Bright light therapy (1)
- Brms (1)
- Brodalumab (1)
- Bromodomänen (1)
- Bronchial challenge (1)
- Bronchial inflammation (1)
- Bronchiale Hyperreagibilität (1)
- Bronchialkrebs (1)
- Bronchiolitis (1)
- Bronchiolitis obliterans (1)
- Bronchitis severity scale (1)
- Broncho-alveoläre Lavage (1)
- Bronchodilator agents (1)
- Bronchopulmonary dysplasia (1)
- Brownian dynamics simulation (1)
- Browsertool (1)
- Brust (1)
- Brustkrebs ; Klinische Medizin ; Kontrollierte klinische Studie (1)
- Bundesärztekammer / Ausschuss Arbeitsmedizin (1)
- Bungarus (1)
- Bungarus walli (1)
- Bunyavirus (1)
- Buparlisib (1)
- Bupivacain (1)
- Bupivacaine (1)
- Burden (1)
- Burkholderia arboris (1)
- Burkitt’s lymphoma (1)
- Burnout-Syndrom (1)
- Burns (1)
- Burst (1)
- Business strategy in drug development (1)
- Butterworth filters (1)
- Butyrate (1)
- Bypass liner (1)
- Bühnentanz (1)
- Büroangestellte (1)
- Büroarbeit (1)
- C-clamp (1)
- C-reactive proteins (1)
- C-reaktive protein (1)
- C-reäktives Protein (1)
- C1 esterase inhibitor (human) (1)
- C1-INH (C1 inhibitor, C1-esterase inhibitor) (1)
- C1-esterase inhibitor protein (1)
- C1-inhibitor (1)
- C1-inhibitor concentrate (1)
- C1-inhibitor deficiency (1)
- C2 domain (1)
- C3M (1)
- C4M (1)
- C5 acylcarnitine (1)
- C57BL/6J mice (1)
- C57BL/6N mice (1)
- C6 ceramide (1)
- CA (1)
- CA1 (1)
- CAD-CAM (1)
- CAD/ CAM crown (1)
- CAD/CAM crown (1)
- CAKUT (1)
- CAPON (1)
- CAR T cells (1)
- CAR-NK cell (1)
- CAR-T cell (1)
- CAR-immunotherapy (1)
- CAT (1)
- CBC (1)
- CBCT (1)
- CBT (1)
- CCC-2 (1)
- CCN2 (1)
- CCTT (1)
- CD107-Assay (1)
- CD137 (1)
- CD23 (1)
- CD271 (1)
- CD3 (1)
- CD3/19 depletion (1)
- CD3/CD19 depletion (1)
- CD34 (1)
- CD34 selection (1)
- CD34+ cell enumeration (1)
- CD34 + cells (1)
- CD4 binding site (1)
- CD4+ T cells (1)
- CD4+ T lymphocytes (1)
- CD40 (1)
- CD41 (1)
- CD45RA Depletion (1)
- CD45RA naïve lymphocytes (1)
- CD47 (1)
- CD49d (1)
- CD56 (1)
- CD62L (1)
- CD62P (1)
- CD62p+Exosomes (1)
- CD74 (1)
- CD8 (1)
- CD8+ T cell (1)
- CD8+ T cells (1)
- CD8+ T lymphocytes (1)
- CD8+ T-cell mediated tumor suppression (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CD8+ zytotoxische T-Zellen (1)
- CD95/Fas receptor (1)
- CDH13 (1)
- CDI (1)
- CDK inhibitor (1)
- CDK-cyclin axis (1)
- CDK2 (1)
- CDK4/6 inhibitor (1)
- CDK4/6 inhibitors (1)
- CDK4/CDK6 (1)
- CDKN2A (1)
- CE (1)
- CE marking (1)
- CE-Kennzeichnung (1)
- CEBPD (1)
- CEBPE (1)
- CEST (1)
- CEST EPI (1)
- CGD (1)
- CGN codon (1)
- CHA2DS2-VASc-score (1)
- CHAID-Analyse (1)
- CHAID-Analysis (1)
- CHEPs (1)
- CHRDL1 (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- CIE-11 (1)
- CIK cell (1)
- CIM (1)
- CK2α (1)
- CLEC-2 (1)
- CLIF-C ACLF score (1)
- CLIF-C ACLF-R score (1)
- CLOCC (1)
- CLS (1)
- CMR (1)
- CMS (1)
- CMV isolation (1)
- CMV risk groups are: pregnancy - blood transfusion - organ transplantation - prostitutes (1)
- CMV-Isolierung (1)
- CMVepidemiology (1)
- CNDAC (1)
- CNP (1)
- CNS (1)
- CNS cancer (1)
- CNS infection (1)
- CNS melanoma (1)
- CNS toxicity (1)
- CNS tumor (1)
- CNV (1)
- CNVs (1)
- CO2-induced forced ventilation (1)
- COBAS Taqman (1)
- COBL (1)
- COI (1)
- COII (1)
- COINS (1)
- COMT (1)
- COPD assessment test (1)
- COPD course and therapy (1)
- COVID (1)
- COVID 19 pandemic (1)
- COVID-19 epitope signatures (1)
- COVID-19 regulations (1)
- COVID-19 vaccination (1)
- COVID-19, Primary care (1)
- COVID‐19 (1)
- CPET (1)
- CPT1A (1)
- CPTAC (1)
- CPVT (1)
- CQL (1)
- CRBN (1)
- CRC65 (1)
- CRE-dependent transcription (1)
- CRE-luciferase (1)
- CREB inhibitor (1)
- CRF (1)
- CRISPR screen (1)
- CRISPR-Cas9 gene conversion (1)
- CRISPR/dCas9 (1)
- CRM1 (1)
- CRPC (1)
- CRT (1)
- CRT-D (1)
- CRVO (1)
- CSC marker (1)
- CT dual-energy computed tomography (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CT-guidance (1)
- CT-guided interventions (1)
- CTC (1)
- CTX (1)
- CTX and NTX (1)
- CTX und NTX (1)
- CUELA system (1)
- CUP (1)
- CVD biomarker (1)
- CVID (1)
- CWS Studiengruppe (1)
- CX-2 (1)
- CXCL10 (1)
- CXCL16 (1)
- CXCR3 antagonism (1)
- CXCR5 (1)
- CY-503 (1)
- CYBA/p22phox (1)
- CYP1A1 (1)
- CYP450 (1)
- Ca2+ imaging (1)
- CaMPARI (1)
- Cabozantinib (1)
- Caco 2 cells/metabolism (1)
- Caco‐2 cells (1)
- Caffeine (1)
- Calcium calmodulin kinase (1)
- Calcium gluconate (1)
- Calcium recordings (1)
- Calcium signalling (1)
- Calcium waves (1)
- Calciumphosphatprodukt (1)
- Call for action (1)
- Calliphora (1)
- Calnexin (1)
- Calstabin2/FKBP12.6 (1)
- Canada (1)
- Cancer Staging (1)
- Cancer cell migration (1)
- Cancer check up (1)
- Cancer detection (1)
- Cancer development (1)
- Cancer epigenetics (1)
- Cancer of unknown primary (1)
- Cancer progression (1)
- Cancer risk factors (1)
- Cancer staging (1)
- Cancer stem cells (1)
- Cancer survivors (1)
- Cancer therapeutic resistance (1)
- Cancer-specific survival (1)
- Candida spp (1)
- Cannabis-based Medicine (1)
- Capacity deficit (1)
- Capillary-Leak-Syndrom (1)
- Capnography (1)
- Capsaicin (1)
- Capsule endoscopy, video (1)
- Carbapenem-resistente Gram-negative Bakterien (CRGN) (1)
- Carbapenemasen (1)
- Carbohydrates (1)
- Carbon tetrachloride (1)
- Carcinogenese (1)
- Carcinogenität (1)
- Carcinoma penis (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac (1)
- Cardiac Fibrosis (1)
- Cardiac acoustic biomarkers (1)
- Cardiac biomarkers (1)
- Cardiac causes of death (1)
- Cardiac device therapy (1)
- Cardiac fibroblast (1)
- Cardiac function (1)
- Cardiac implantable electronic devices (1)
- Cardiac infarction (1)
- Cardiac masses (1)
- Cardiac monitoring (1)
- Cardiac necroenzymes (1)
- Cardiac output (1)
- Cardiac rehabilitation (1)
- Cardiac remodeling (1)
- Cardiac remodelling (1)
- Cardiac resynchronization therapy (1)
- Cardiac surgery patients (1)
- Cardiac troponin (1)
- Cardiavascular function (1)
- Cardio-oncology (1)
- CardioMEMS™ HF system (1)
- Cardiogenic shock (1)
- Cardiomyocyte signaling pathways (1)
- Cardiomyopathy (1)
- Cardiopulmonary bypass (1)
- Cardiotoxicity (1)
- Cardiovascular Magnetic Resonance (CMR) (1)
- Cardiovascular disease risk (1)
- Cardiovascular epidemiology (1)
- Cardiovascular genetics (1)
- Cardiovascular mortality (1)
- Cardiovaskuläre Erkrankungen (1)
- Care centers (1)
- Care gaps (1)
- Care home (1)
- Career promotion (1)
- Careers (1)
- Caritas (1)
- Carotid injury (1)
- Carotid stenosis (1)
- Carrier-bound fibrin sealant (1)
- Cartilage (1)
- Cartilage Biology (1)
- Cas9 inhibitor (1)
- Case management [MeSH] (1)
- Casirivimab (1)
- Caspase-8 (1)
- Caspasen (1)
- Castleman’s disease (1)
- Castor bean tick (1)
- Catch-up validation study (1)
- Catel, Werner (1)
- Catheters (1)
- Catumaxomab (1)
- Causality (1)
- Causality assessment. (1)
- Cause of death (1)
- Cdk1/cyclin B1 (1)
- Cell Biology (1)
- Cell Death (1)
- Cell Metabolism (1)
- Cell Migration (1)
- Cell Signaling (1)
- Cell Surface Receptor (1)
- Cell adhesion (1)
- Cell cultures (1)
- Cell cycle (1)
- Cell distribution (1)
- Cell membranes (1)
- Cell metabolism (1)
- Cell motility (1)
- Cell plasticity (1)
- Cell processing (1)
- Cell surface proteoglycans (1)
- Cell-assisted lipotransfer (1)
- Cell-based Assays (1)
- Cell-based therapies (1)
- Cell-to-Cell Spread (1)
- Cellular (1)
- Cellular energy metabolism (1)
- Cellular imaging (1)
- Cellular inflammatory response (1)
- Cellular network formation (1)
- Cellular neuroscience (1)
- Cellular stress (1)
- Cellular stress responses (1)
- Cement gap (1)
- Cementation (1)
- Center-specific time in therapeutic range (cTTR) (1)
- Centers for Disease Control and Prevention (1)
- Central Europe (1)
- Central nervous system (1)
- Central nervous system metastases (1)
- Centrifugation (1)
- Cephalometry via electromagnetic induction (1)
- Cephalometry without x-rays (1)
- Ceramic (1)
- Ceramide (1)
- Ceramide Synthase (1)
- Ceramides (1)
- Cerasorb (1)
- Cerclage (1)
- Cerebellar ataxia (1)
- Cerebral Vasospasm (1)
- Cerebral hypoperfusion (1)
- Cerebral ischemia (1)
- Cerebral oxygen saturation (1)
- Cerebral toxoplasmosis HIV (1)
- Cerebral vasospasm (1)
- Cerebrospinal Fluid (1)
- Cerebrospinal fluid diagnostics (1)
- Cerebrovascular (1)
- Cerebrovascular disorders (1)
- Certification (1)
- Cervical (1)
- Cesarean delivery (1)
- Cethromycin (1)
- ChAdOx1-S (1)
- Chagas (1)
- Change Management (1)
- Chaperones (1)
- Checkliste (1)
- Checkpoint Inhibitor (1)
- Checkpoint kinase (1)
- Checkpoints (1)
- Chemical company (1)
- Chemical ecology (1)
- Chemical labeling (1)
- Chemical modification (1)
- Chemikalie (1)
- Chemiluminescence (1)
- Chemische Sonden (1)
- Chemobrain (1)
- Chemoembolization (1)
- Chemoinformatics (1)
- Chemokine CCL2 (1)
- Chemoradiation (1)
- Chemorefractory advanced gastric cancer (1)
- Chemosensitivity (1)
- Chest pain unit (1)
- Chewa (1)
- Chewa-Sprache (1)
- Chichewa (1)
- Chikungunya (1)
- Chikungunya virus (1)
- Child adiposity (1)
- Child and adolescent psychotherapy (1)
- Child health (1)
- Childhood (1)
- Childhood abuse (1)
- Childhood sexual abuse (1)
- Chimeric Antigen Receptor (CAR) (1)
- Chimerism (1)
- Chimiothérapie (1)
- Chinesischer Rhabarber (1)
- Chinoxalinderivate (1)
- Chlamydia-Infections/urine (1)
- Chlamydien (1)
- Chlamydieninfektionen/Urin (1)
- Chloralhydrat (1)
- Chloroform (1)
- Chloroquin (1)
- Cholecystectomy (1)
- Cholesterinveresterung (1)
- Cholesterol (1)
- Cholinergic (1)
- Chondral Lesion (1)
- Chondrocyte (1)
- Chondrocyte signalling (1)
- Chrna7 knockout (1)
- Chrom (1)
- Chromatin and Epigenetics (1)
- Chromatin conformation (1)
- Chromodomains (1)
- Chromoendoscopy (1)
- Chromosom (1)
- Chromosomal deletion (1)
- Chromosomal translocations (1)
- Chromosomale Translokation (1)
- Chronic Hepatitis C (1)
- Chronic ankle instability (1)
- Chronic care model (1)
- Chronic conditions (1)
- Chronic disease [MeSH] (1)
- Chronic health condition (1)
- Chronic heart failure (1)
- Chronic hepatitis C virus (1)
- Chronic illness (1)
- Chronic infection (1)
- Chronic intestinal failure (1)
- Chronic lymphocytic leukemia (1)
- Chronic medical conditions (1)
- Chronic obstructive airway disease (1)
- Chronic pain (1)
- Chronic pancreatitis (1)
- Chronic periodontiti (1)
- Chronification (1)
- Chronisch aktive/Diagnostik (1)
- Chronisch-venöse Insuffizienz (1)
- Chronische Fehl- und Überlastungsschäden (1)
- Chronische Krankheit (1)
- Chronische Niereninsuffizienz (1)
- Chronischer Schmerz (1)
- Chronology of disease (1)
- CiNyungwe (1)
- Cigarette (1)
- Cigarettes (1)
- Cindau (1)
- Cine (1)
- Cinnarizine (1)
- Cinryze® (1)
- Ciprofloxacin (1)
- Circadian (1)
- Circadian rhythms and sleep (1)
- Circulating MiRNA (1)
- Circulating markers (1)
- Circulating miRNA (1)
- Circulation (1)
- Cirugía (1)
- Cisplatinresistenz (1)
- Citation (1)
- Citationrate (1)
- Cities (1)
- Citrat (1)
- Civil liberties (1)
- Civil protection (1)
- Claudin 5 (1)
- Clavien–Dindo classification (1)
- Cleanliness level (1)
- Cleft palate (1)
- Click chemistry (1)
- Climate (1)
- Climate change (1)
- Climate inequity (1)
- Clincial pharmacology (1)
- CliniMACS (1)
- Clinical Decision Support System (1)
- Clinical Skills (1)
- Clinical effectiveness (1)
- Clinical efficacy (1)
- Clinical frailty scale (1)
- Clinical management (1)
- Clinical neuropsychology (1)
- Clinical outcome (1)
- Clinical pathway (1)
- Clinical pathways (1)
- Clinical pharmacology (1)
- Clinical phenotype (1)
- Clinical practice guidelines (1)
- Clinical psychometry (1)
- Clinical skills (1)
- Clinical variation (1)
- Clinician-administered PTSD Scale PTSD (1)
- Clip (1)
- Cln3 (1)
- Clonidin (1)
- Clonidine (1)
- Clopidogrel (1)
- Clostridioides difficile (1)
- Clostridium (1)
- Closure (1)
- ClpB (1)
- Cluster (1)
- Cluster randomization (1)
- Clustering coefficients (1)
- Co-culture (1)
- Co-morbidity (1)
- Coagulation (1)
- Coagulopathy management (1)
- Cocain (1)
- Cochlear Implant (1)
- Codierung (1)
- Coexistence (1)
- Cofilin (1)
- Cognitive (1)
- Cognitive behavioural therapy (1)
- Cognitive control (1)
- Cognitive dysfunction (1)
- Cognitive enhancers of exposure therapy (1)
- Cognitive neurology (1)
- Cognitive psychology (1)
- Cognitive training (1)
- Cognitive-motor interference (1)
- Coherent infomax (1)
- Cohort Analysis (1)
- Cohort study (1)
- Colchicum (1)
- Cold hardiness (1)
- Cold pain (1)
- Cold tolerance (1)
- Colitis Ulcerosa (1)
- Colitis assoziate colorectal cancer (1)
- Collagen antibody-induced arthritis (1)
- Collagen hemostat (1)
- Collagen type I (1)
- Collagen type III (1)
- Collagen-based biomaterial (1)
- Collective cell migration (1)
- Colon cancer (1)
- Colon capsule endoscopy (1)
- Colonic neoplasms (1)
- Colonisation (1)
- Colonkrebs (1)
- Colony stimulating factor 1 receptor (1)
- Colorectal Cancer (1)
- Colorimetric blood loss estimation (1)
- Combined immune checkpoint blockade (1)
- Combined surgical therapy (1)
- Combo® DTS (1)
- Combustion (1)
- Commercial Immunoglobulins (1)
- Communicable diseases (1)
- Communication-through-coherence (CTC) (1)
- Comparative analysis (1)
- Comparative effectiveness research (1)
- Comparative study (1)
- Comparators (1)
- Compartmental modeling (1)
- Competencies (1)
- Complement Regulator (1)
- Complement cascade (1)
- Complement system (1)
- Complementary medicine (1)
- Complementation rate (1)
- Complete heart block (1)
- Complete response (1)
- Completed suicide (1)
- Complex Systems (1)
- Complex decongestive therapy (1)
- Complex elbow fractures (1)
- Complex hernia (1)
- Complex networks (1)
- Complexin 1 (1)
- Complexin-1 (1)
- Compliance-Beobachtung (1)
- Complicated appendicitis (1)
- Complicated stage (1)
- Complication (1)
- Comprehensive cancer centers (1)
- Comprehensive complication index (1)
- Compression stocking (1)
- Computational chemistry (1)
- Computed Tomography (1)
- Computed axial tomography (1)
- Computed tomography imaging (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computed tomography, X-ray (1)
- Computer simulation (1)
- Computer-Assisted (1)
- Computer-Tomographie (CT) gesteuerte Verfahren (1)
- Computer-aided drug design (1)
- Computer-unterstützte (1)
- Computers (1)
- Computerspielstörung (1)
- Concept paper (1)
- Conception (1)
- Concurrent CNS diseases (1)
- Concurrent chemoradiotherapy (1)
- Conditional gene trap (1)
- Conduct problems (1)
- Conduit function (1)
- Cone-beam computed tomography (1)
- Confinement (1)
- Confocal endomicroscopy (1)
- Conformational change (1)
- Congenital (1)
- Congenital CMVinfection (1)
- Congenital anomalies (1)
- Congenital diaphragmatic hernia (1)
- Congenital duodenal obstruction (1)
- Congenital ocular motor apraxia (1)
- Coniosporium corticale (1)
- Connectivity (1)
- Conometric connection (1)
- Conscious perception (1)
- Consciousness (1)
- Consensus document (1)
- Consensus methods (1)
- Consensus statement (1)
- Conservation (1)
- Conservative (1)
- Conservative treatment (1)
- Consolidation (1)
- Consortia (1)
- Constipation (1)
- Constitution (1)
- Constrained posture (1)
- Contact network (1)
- Contact precautions (1)
- Contamination (1)
- Contingent Negative Variation, CNV (1)
- Continuous Performance Test, CPT (1)
- Continuous Process Verification (1)
- Continuous renal replacement therapy (1)
- Contraceptifs hormonaux (1)
- Contractile function (1)
- Contrast agent (1)
- Contrast-Enhancing Lesions (1)
- Contrast-enhanced (1)
- Contrastive analysis (1)
- Control (1)
- Conventional Chemotherapeutic (1)
- Conventional and unconventional ubiquitination (1)
- Conventional dendritic cells (1)
- Conventional synthetic disease-modifying antirheumatic drug (1)
- Convolutional Neural Networks (1)
- Cooperation (1)
- Coordination Of Control Modes (1)
- Copy number (1)
- Copy number variation (1)
- Cord blood transplantation (1)
- Cordichin (1)
- Core needle biopsy (1)
- Cornea (1)
- Corneal tomography (1)
- Corneometrie (1)
- Corona pandemic (1)
- Corona virus (1)
- Coronary artery disease (CAD) (1)
- Coronary intervention (1)
- Coronaviren (1)
- Coronaviruses (1)
- Cortical column (1)
- Cortical degeneration (1)
- Cortical thickness (1)
- Corticotropic axis (1)
- Cortisol (1)
- Cost And Quality Management (1)
- Cost-effectiveness analysis (1)
- Couch tracking (1)
- Council for International Organizations of Medical Sciences (1)
- Course (1)
- Course evaluation (1)
- Covid19-nmr (1)
- Cox-2-Inhibitoren (1)
- Cox-Regression (1)
- Coxibs (1)
- Coxsackieviren (1)
- Cp (1)
- Cpk (1)
- Craniomandibular disorders (1)
- Craniomaxillofacial injuries (1)
- Cre-recombinase (1)
- Creatinine (1)
- Credentialing (1)
- Creeping Disease (1)
- Crisis (1)
- Crispr/Cas (1)
- Critical Online Reasoning Assessment (1)
- Critical bleeding (1)
- Critical care and emergency medicine (1)
- Critical haematocrit (1)
- Critical pathway (1)
- Critical size (1)
- Cross- sectional study (1)
- Cross-border mobility (1)
- Cross-contamination (1)
- Cross-frequency coupling (1)
- Cross-sectional (1)
- Cross-sectional study (1)
- Crosscorrelation (1)
- Crossmodal (1)
- Cryo-electron microscopy (1)
- Cryoablation (1)
- Cryoballoon (1)
- Cryptococcus (1)
- Cryptostroma corticale (1)
- CspA (1)
- Cue-P3 (1)
- Culex pipiens (1)
- Culex pipiens biotypes pipiens/molestus (1)
- Culture (1)
- Culture positive (1)
- Cumulative dose (1)
- Curcumin (1)
- Curcumin micelles (1)
- Curcuminoid concentrations (1)
- Curcumis sativus (1)
- Cure (1)
- Curvilinear dose response (1)
- Cushing-Syndrom (1)
- Cushing’s syndrome (1)
- Custom-made mouthguard (1)
- Cuticular hydrocarbons (1)
- Cy5.5 (1)
- Cyanoacrylate (1)
- CyberKnife (1)
- Cyborg (1)
- Cyclic GMP (1)
- Cyclin T1 (1)
- Cyclocymopol-Derivat (1)
- Cyclooxygenase (1)
- Cyclosporin A (1)
- Cyp46a1 (1)
- Cystatin C (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cytochrome P450 (1)
- Cytochrome P450 enzymes (1)
- Cytokines Induction (1)
- Cytology (1)
- Cytomegalie (1)
- Cytomegalie-Virus (1)
- Cytomegalievirus (1)
- Cytomegalovirus (1)
- Cytomegalovirus (CMV) (1)
- Cytomegalovirus Infection (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytoreductive nephrectomy (1)
- Cytotoxic CD8+ T cell (1)
- Cytotoxicity (1)
- C‐reactive protein (1)
- D-amino acid oxidase (1)
- D-dimer (1)
- D2-autoreceptor (1)
- DAMP (1)
- DAMPs (1)
- DAN-G (1)
- DBH genotype (1)
- DBS (1)
- DC-NK cell interaction (1)
- DCK (1)
- DCM (1)
- DDA (1)
- DDDPlus (1)
- DDIT4 (1)
- DDX6 (1)
- DEE (1)
- DFNB9 (1)
- DHA (1)
- DILI database case quality (1)
- DIN EN ISO 15189 (1)
- DIRAS2 (1)
- DJ-Katheter (1)
- DKK1 (1)
- DKTK-ROG (1)
- DLBCL (1)
- DLI (1)
- DLPFC (1)
- DMARDs (synthetic) (1)
- DME (1)
- DMXAA (1)
- DNA Adducts (1)
- DNA Damage (1)
- DNA double-strand break repair (1)
- DNA integrity (1)
- DNA repair (1)
- DNA replication (1)
- DNA sequence analysis (1)
- DNA sequencing (1)
- DNA, Virale/Blut (1)
- DNA-Methylierung (1)
- DNA-PAINT (1)
- DNA-PK (1)
- DNA-based identification (1)
- DNA-binding proteins (1)
- DNA-protein crosslinks (1)
- DOK1 (1)
- DOT1L (1)
- DPPIV (1)
- DR5 (1)
- DRG (1)
- DRIL-Procedur (1)
- DRIL-procedure (1)
- DSAEK (1)
- DSS /AOM (1)
- DST (1)
- DTHR (1)
- DUBs (1)
- DVI (1)
- DVT (1)
- DWI (1)
- DYRK1A (1)
- DYT1 (1)
- Dabigatran (1)
- Daboia russelii (1)
- Daclatasvir (1)
- Daily diary (1)
- Dance (1)
- Dancer (1)
- Dark triad (1)
- Darmerkrankung (1)
- Darreichungsform (1)
- Darunavir (1)
- Data Analysis (1)
- Data acquisition (1)
- Data exploration (1)
- Data mining (1)
- Data monitoring (1)
- Data preprocessing (1)
- Data protection (1)
- Data reduction (1)
- Data structure detection (1)
- Data validation (1)
- Data visualization (1)
- Databases (1)
- Dataset bias (1)
- Datenanalyse (1)
- Datenqualität (1)
- Daubert criteria (1)
- Dauerversorgung (1)
- David technique (1)
- De-isolation (1)
- Dead space (1)
- Death certificate (1)
- Decay (1)
- Decision Confidence (1)
- Decision impact (1)
- Decision support (1)
- Decision-making (1)
- Declaration of Cologne (1)
- Decolonization (1)
- Decontamination (1)
- Deep learning (1)
- Deep neural network (1)
- Deep vein thrombosis (1)
- Default-mode network (1)
- Defekt (1)
- Deficient Inhibition (1)
- Definition Gesundheit (1)
- Deformation (1)
- Degrader design (1)
- Dehnen (1)
- Dehnen verkürzter Muskulatur (1)
- Dehntraining (1)
- Delay of gratification (1)
- Delayed Cerebral Ischemia (1)
- Delayed Infectivity Panning (1)
- Delayed union (1)
- Deletion mutation (1)
- Delivery mode (1)
- Delivery quality assurance (1)
- Delphi Survey (1)
- Delphie-Befragung (1)
- Demenzerkrankung (1)
- Demersal fish (1)
- Democracy (1)
- Dendritic Cells (1)
- Dendritic cell (1)
- Dendritic cell population (1)
- Dendritic cells (1)
- Dendritic spines (1)
- Dendritic structure (1)
- Dendritische Zelle (1)
- Denervation (1)
- Dengue fever (1)
- Dengue fever virus (1)
- Denguefieber (1)
- Density equalizing (1)
- Dental air (1)
- Dental assistants (1)
- Dental casts (1)
- Dental education (1)
- Dental phobia (1)
- Dental practice (1)
- Dental training (1)
- Dentale Implantate (1)
- Dentalkeramik; Grünling <Technik>; CAM; Hartmetallwerkzeug; Werkzeugverschleiß; Dimensionsstabilität; Schleifwerkzeug; Diamantwerkzeug (1)
- Dentin adhesives (1)
- Dentition (1)
- Depolarization (1)
- Depression stigma (1)
- Dermatitis (1)
- Dermatomyositis (1)
- Dermatopharmakokinetik (1)
- Desinfektion von Flugzeugen (1)
- Desmin (1)
- Detection (1)
- Detection workflow (1)
- Determination method (1)
- Detraining (1)
- Deubiquitination (1)
- Deutsch als Zweitsprache (1)
- Deutsch-Ostafrika (1)
- Deutsche Gesellschaft für Arbeitsmedizin (1)
- Deutsche Gesellschaft für Chirurgie (1)
- Deutscher Gewerkschaftsbund (1)
- Deutsches Rotes Kreuz (1)
- Deutschland / Bundesministerium für Gesundheit (1)
- Deutschland / Fallpauschalengesetz (1)
- Developmental Biology (1)
- Developmental disorders (1)
- Developmental programming (1)
- Developmental trajectory (1)
- Developmentally adapted cognitive processing therapy (1)
- Devic disease (1)
- Devic syndrome (1)
- Device (1)
- Dexamethasone (1)
- Dexterity (1)
- DiI (1)
- Diabetes mellitus Typ 1 und Typ 2 (1)
- Diabetes mellitus Typ 2 (1)
- Diabetic nephropathy (1)
- Diadenosinpolyphosphate (1)
- Diagnosen ICD-10 Ziffern G41.0, G41.1, G41.2, G41.8, G41.9 (1)
- Diagnosenschlüssel (1)
- Diagnoses ICD-10 codes G41.0, G41.1, G41.2, G41.8, G41.9 (1)
- Diagnosezeitpunkt (1)
- Diagnosis related groups (1)
- Diagnostic differentiation (1)
- Diagnostic dye (1)
- Diagnostic error (1)
- Diagnostic imaging (1)
- Diagnostic techniques and procedures (1)
- Diagnostic tests (1)
- Diagnostik von MLL Translokationen (1)
- Dialectical behavioral therapy (1)
- Dialyse-assoziiertes Steal-Syndrom (1)
- Dialysis-associated Steal Syndrome (1)
- Diary Data (1)
- Diastolische Dysfunktion (1)
- Dichloromethane (1)
- Dichtebestimmung (1)
- Dickdarmkrebs (1)
- Dictyostelium discoideum ; Retrotransposon ; t-DNS ; Nachweis ; In vivo (1)
- Didaktik (1)
- Diesel (1)
- Diet (1)
- Dietary HDAC inhibitor (1)
- Dietary intake (1)
- Dietary supplements (1)
- Dieulafoy’s lesion (1)
- Differential Scanning Calorimetry (DSF) (1)
- Differential equations (1)
- Differential expression (1)
- Difficult Airway Management (1)
- Diffuse astrocytoma (1)
- Diffuse large B cell lymphoma (1)
- Diffuse large B-cell lymphoma (1)
- Diffusion (1)
- Diffusion Tensor Imaging (1)
- Diffusion magnetic resonance imaging (1)
- Diffusion of Innovations (1)
- Diffusion-Weighted Imaging (1)
- Diffusions-Tensor-Bildgebung (1)
- Diffusionsbildgebung (1)
- Diflapolin (1)
- Digenic model (1)
- Digestive system (1)
- Digital (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital ethics (1)
- Digital hybrid visualization (1)
- Digital mammography (1)
- Digital pathology (1)
- Digital rectal examination (1)
- Digital subtraction angiography (1)
- Digital transformation (1)
- Digital workshops (1)
- Digitale Ethik (1)
- Digitale Pathologie (1)
- Digitale Transformation (1)
- Digitale Volumen Tomographie (1)
- Digitization (1)
- Dilated cardiomyopathy (1)
- Dimer (1)
- Dimers (Chemical physics) (1)
- Dimethyltryptamine (1)
- Dioecy (1)
- Dioscorea (1)
- Dipeptide (1)
- Diphosphonates (1)
- Diphtheria (1)
- Direct Acting Antivirals (DAA) (1)
- Direct acting antiviral therapies (1)
- Direct measurement (1)
- Direct oral anticoagulation (1)
- Direct-acting antiviral agents (DAAs) (1)
- Direct-acting antivirals (1)
- Disabilities (1)
- Disability (1)
- Disabling back pain (1)
- Disaster victim identification (1)
- Discitis (1)
- Disconnection (1)
- Discovery (1)
- Discs large (1)
- Disease burden (1)
- Disease management (1)
- Disease progression (1)
- Disinfection of aircraft (1)
- Diskonnektion (1)
- Diskursanalyse (1)
- Dislocations of the knee (1)
- Displacement (1)
- Dissemination (1)
- Dissociative seizures (1)
- Dissolution nanoparticles (1)
- Distale Revascularisation- Intervall Ligatur (1)
- Distance learning (1)
- Distanzunterricht (1)
- Distress (1)
- Distress screening (1)
- Distribution (1)
- Distribution limits (1)
- Disturbancies and mistakes (1)
- Dizygotic ectopic (1)
- Doctors In Management (1)
- Dog (1)
- Dogs (1)
- Domestic (1)
- Donau (1)
- Donor Selection (1)
- Donor T cells (1)
- Donor screening (1)
- Doppler-Sonographie (1)
- Dorsal root ganglia (1)
- Dorsolateral prefrontal cortex (1)
- Dose optimization (1)
- Dosiskonzepte (1)
- Dot-probe task (1)
- Double balloon enteroscopy (1)
- Double suicide (1)
- Double-blind placebo-controlled trial (1)
- Doubling time (1)
- Douleur (1)
- Down's syndrome (1)
- Downgrading (1)
- Downy mildew (1)
- Doxorubicin (1)
- Doxycyclin (1)
- Doxycycline (1)
- Dravet (1)
- Drogenabhängigkeit (1)
- Drogenhilfe (1)
- Drogenkonsum (1)
- Drogentherapie (1)
- Drogentote (1)
- Droplets (1)
- Drosophila (1)
- Drosophila melanogaster (1)
- Drospirenon (1)
- Drought (1)
- Drug (1)
- Drug Delivery (1)
- Drug Resistance (1)
- Drug Therapy (1)
- Drug addiction (1)
- Drug delivery systems (1)
- Drug discovery and development (1)
- Drug interactions (1)
- Drug permeability (1)
- Drug resistance/synergy (1)
- Drug safety (1)
- Drug screens (1)
- Drug susceptibility testing (1)
- Drug targeting (1)
- Drug targets (1)
- Drug-Drug Interactions (1)
- Dual energy CT (1)
- Dual task walking (1)
- Dual therapy (1)
- Dual-Source CT (1)
- Dual-energy computed tomography (1)
- Duchenne’s muscular dystrophy (1)
- Dumon stents (1)
- Duodenal atresia (1)
- Duodenal stenosis (1)
- Duodenum (1)
- Dural onlays (1)
- Durchblutungsstörung (1)
- Durchseuchung (1)
- Dvc1 (1)
- Dynamical systems (1)
- Dysfibrinogenämia (1)
- Dysfunctional social assumptions (1)
- Dyslexia (1)
- Dysphagia (1)
- Désir d’enfant (1)
- D’Amico classification (1)
- E protein structure (1)
- E-NTPDase (1)
- E-cadherin (1)
- E-cadhérine (1)
- E-health (1)
- E-learning (1)
- E/I-Balance (1)
- E2F-1 (1)
- EAA (1)
- EASI (1)
- EBRA-FCA (1)
- EBRT (1)
- ECLS (1)
- ECM (1)
- EDB (1)
- EDTA-plasma (1)
- EEC syndrome (1)
- EEG reference choices (1)
- EEG-TMS (1)
- EFP1 (1)
- EFRS (1)
- EGF (1)
- EGF-Rezeptor (1)
- EGFL7 (1)
- EGFP (1)
- EGFR inhibitor (1)
- EGFR pathway (1)
- EGFRvIII mutation (1)
- EGR1-dependent transcription (1)
- EGR1/2/3 (1)
- EHL concentrates (1)
- EIIIB (1)
- EKoti (1)
- ELISPOT (1)
- ELSID-Diabetes (1)
- EMD 55900 (1)
- EMD 72000 (1)
- EMR1 (1)
- EN ISO 15189 (1)
- ENIGMA (1)
- EOB (1)
- EP300 (1)
- EPA (1)
- EQ (1)
- EQ5D5L (1)
- EQA scheme (1)
- EQIP (1)
- ER-phagy (1)
- ERAL1 (1)
- ERBB2 (1)
- ERBB2 (HER2/neu) (1)
- ERCP (1)
- ERK inhibitor (1)
- ERK1/2 signaling (1)
- ERK3 (1)
- ERK3/MAPK6 (1)
- ERM (1)
- ERMS (1)
- ES (1)
- ES cells (1)
- ESMO-MCBS (1)
- ESR Spectroscopy (1)
- ESR and Infrared Studies (1)
- ESWT (1)
- ET (1)
- ET-MP (1)
- ETP-ALL (1)
- ETS (1)
- EWS/Fli1 (1)
- EZ-IO® needle driver (1)
- Early (prenatal and postnatal) life experiences (1)
- Early Rheumatoid Arthritis (1)
- Early diagnosis (1)
- Early goal-directed therapy (1)
- Early intervention (1)
- Early recurrence (1)
- Early setting (1)
- Ebola (1)
- Echocardiography (1)
- Echovirus-30 (1)
- Eclampsia (1)
- Ecological Momentary Assessment (EMA) (1)
- Ecological momentary assessment (1)
- Ecological niche modelling (1)
- Economic analysis (1)
- Economic benchmarks (1)
- Economic botany (1)
- Economic evaluation (1)
- Economic impact (1)
- Economics (1)
- Ecosystem health (1)
- Ecto-5'-nucleotidase (1)
- Ectopic bone formation (1)
- Ectopic pregnancy (1)
- Ectopic varices (1)
- Edentulous jaw (1)
- Edinger, Ludwig (Arzt) (1)
- Educación médica (1)
- Efavirenz (1)
- Effective connectivity (1)
- Effective half-life (1)
- Effectivity (1)
- Eicosanoide (1)
- Eicosanoids (1)
- Eignungsprüfung (1)
- Einfachauswahlverfahren (1)
- Einflussnahme (1)
- Eingangstest (1)
- Eingeborene (1)
- Einmaleinnahme (1)
- Einreibetechnik (1)
- Einstellung (1)
- Einstellungen (1)
- Einstellungen zu Impfungen (1)
- Einwilligungsfähigkeit (1)
- Einzelzahnimplantate (1)
- Eisenbestimmung (1)
- Eisenmangel (1)
- Eisenstoffwechsel (1)
- Ektachem® (1)
- Elastogenesis (1)
- Elastographie (1)
- Elbow (1)
- Elderly patients (1)
- Elderly trauma patient (1)
- Elective caesarean section (1)
- Electric stimulation (1)
- Electrical accident (1)
- Electrical and electronic engineering (1)
- Electrical instability (1)
- Electroconvulsive Therapy (1)
- Electrode potentials (1)
- Electrolytes (1)
- Electromyography (1)
- Electron microscopy (1)
- Electron transport chain (1)
- Electronic cigarettes (1)
- Electrospinning (1)
- Electrotonic analysis (1)
- Elektrischer Sturm (1)
- Elektroencephalographie (1)
- Elektroenzephalographie (1)
- Elektromyographie (1)
- Elektrophysilogie (1)
- Elimination (1)
- Elite football (1)
- Ellipsoids (1)
- Ellipticine (1)
- Elomwe (1)
- Elternurteil (1)
- Emanzipation (1)
- Embden, Gustav (1)
- Embolie (1)
- Embolization (1)
- Embryos (1)
- Emergency (1)
- Emergency card (1)
- Emergency care (1)
- Emergency medicine (1)
- Emergency treatment (1)
- Emotion processing (1)
- Emotional intelligence (1)
- Emotional recognition (1)
- Empfehlungen (1)
- Empfindlichkeitstestung (1)
- Emphysema (1)
- Employment (1)
- Employment effect (1)
- Empty puparia (1)
- Emx2 (1)
- Ena/VASP proteins (1)
- Encephalitis Viruses (1)
- End-of-life decisions (1)
- Endocrine cancer (1)
- Endocrine system and metabolic diseases (1)
- Endocrine therapy (1)
- Endodontie (1)
- Endogene Retroviren (1)
- Endogene Retroviren ; Schwein ; Heterotransplantation ; Wirt (1)
- Endogene Retroviren; Mensch; Schwein; Genregulation; Wirtsspezifität; Heterotransplantation (1)
- Endogenous RNA-Polymerase (1)
- Endogenous retroviruses (ERV) (1)
- Endoluminal (1)
- Endometrial cancer (1)
- Endometrial carcinoma (1)
- Endometriome (1)
- Endometriose (1)
- Endomicroscopy (1)
- Endométriomes (1)
- Endoplasmic reticulum (1)
- Endoprothese (1)
- Endorectal (1)
- Endoscopic coronary revascularisation (1)
- Endoscopic papillotomy (1)
- Endoscopic retrograde Cholangiopancreatography (ERCP) (1)
- Endoscopic retrograde cholangiography (1)
- Endoscopic sphincterotomy (1)
- Endoscopic treatment (1)
- Endoskopie (1)
- Endoskopik koroner revaskülarizasyon (1)
- Endosomes (1)
- Endothelial (1)
- Endothelial cell (1)
- Endothelial cell (EC) (1)
- Endothelial nitric oxide synthase (1)
- Endothelial progenitor cells (1)
- Endothelial protein C receptor (1)
- Endothelial-to-mesenchymal transition (1)
- Endotheliale Stickstoffmonoxidsynthase (1)
- Endothelzelle (1)
- Endotoxikose (1)
- Endotoxinaktivität (1)
- Endotoxins (1)
- Endourologie (1)
- Endovaskuläre Versorgung (1)
- Endpoint Urea determination (1)
- Endpoints (1)
- Endpunkt-Harnstoffbestimmung (1)
- Endurance training (1)
- Energiebedarf (1)
- Energiedefizit (1)
- Energy (1)
- Energy deficit (1)
- Energy-efficiency (1)
- Enfermedades crónicas (1)
- England (1)
- Engraftment (1)
- Enteral nutrition (1)
- Enteric nervous system (1)
- Enterobacterales (1)
- Enterostomy (1)
- Enterostomy closure (1)
- Enterostomy formation (1)
- Enterovirus 71 (1)
- Entfernung (1)
- Entorhinal cortex lesion (1)
- Entrenamiento práctico (1)
- Entscheidungsfindung (1)
- Entsäuerung (1)
- Entwicklungsbiologie (1)
- Env (1)
- EnvZ signalling (1)
- Envenomation (1)
- Environmental biotechnology (1)
- Environmental chemistry (1)
- Environmental enrichment (1)
- Environmental health (1)
- Environmental impacts (1)
- Environmental sciences (1)
- Enzephalopathie (1)
- Enzym (1)
- Enzymaktivität (1)
- Enzyme Linked Immunosorbent Assay (ELISA) (1)
- Enzyme kinetics (1)
- Enzyme mechanisms (1)
- Enzyme regulation (1)
- Enzyme-linked immunosorbent assay (1)
- Enzymtherapie (1)
- Eosinophilie (1)
- Eosinophils (1)
- EpCAM positive tumor (1)
- Eph receptors (1)
- Ephrin ligand (1)
- Ephrin-B2–EphB4 (1)
- Epidemic (1)
- Epidemie (1)
- Epidemiological data (1)
- Epidemiological statistics (1)
- Epidemiologische Surveillance (1)
- Epidermaler Wachstumsfaktor Rezeptor (1)
- Epidermolysis bullosa simplex with muscular dystrophy (1)
- Epidural abscess (1)
- Epidural block (1)
- Epilepsiechirurgie (1)
- Epilepsiezentren (1)
- Epilepsy Acute seizure plan Antiseizure medication Instructions for action Self-management (1)
- Epilepsy center (1)
- Epilepsy centers (1)
- Epilepsy surgery (1)
- Epileptic seizure (1)
- Epithel (1)
- Epithelial cells (1)
- Epithelialization (1)
- Epithelioma Cells (1)
- Epsilon (1)
- Epstein–Barr virus (1)
- Equality (1)
- Equipment (1)
- Eradication (1)
- ErbB-signaling (1)
- ErbB2; Single-chain Fv Antikörper (1)
- Erblichkeit (1)
- Erdnussallergie (1)
- Ereignis (1)
- Ereigniskorrelierte Felder (1)
- Erfolgsfaktoren (1)
- Ergebnisquantifizierung (1)
- Ergometrie (1)
- Ergometry (1)
- Ergonomic analysis (1)
- Ergonomie am Arbeitsplatz (1)
- Ergonomische Analyse (1)
- Ernährung (1)
- Erprobung (1)
- Erregernachweis (1)
- Erregerspektrum der Tonsillitis (1)
- Erschöpfung (1)
- Erste Hilfe (1)
- Erste-Hilfe-Kurs (1)
- Erwachsener, 50-65 Jahre (1)
- Erythema migrans (1)
- Erythematodes (1)
- Erythrocytes (1)
- Erythrophagocytosis (1)
- Erythropoetin (1)
- Erythropoiesis (1)
- Erythropoietin (1)
- Erythrozytenkonzentrat (1)
- Erythrozytentransfusion (1)
- Erzähltheorie (1)
- Erzählung (1)
- Escala de TEPT administrada por un médico (1)
- Esophageal adenocarcinoma (1)
- Esophageal adenocarcinoma (EAC) (1)
- Esophagectomy (1)
- Esophagogastric (1)
- Estimated glomerular filtration rate (1)
- Estimation of height and sex determination (1)
- Estradiol (1)
- Estrogen Receptor Modulators (1)
- Ether (1)
- Ethics Committees/Consultation (1)
- Ethik (1)
- Ethnicity (1)
- Ethnische Gruppe (1)
- Ethno-ophiology (1)
- Ethnobotany (1)
- Ethnologische Studie (1)
- Eugenik (1)
- European Comparison (1)
- European Society for Immunodeficiencies (ESID) (1)
- European babesiosis (1)
- European registry for idiopathic pulmonary fibrosis (eurIPFreg) (1)
- Europäische Integration (1)
- Europäische Union (1)
- Euthanasie (1)
- Euthymic phase (1)
- Evaluation in microsurgery (1)
- Evaluationspraxis (1)
- Event related potentials (1)
- Event-related potential (1)
- Event-related potentials (1)
- Everolimus resistance (1)
- Evidence-based drug discovery (1)
- Evidence-based guidelines (1)
- Evidenz (1)
- Evidenzbasiert (1)
- Evidenzbasierung (1)
- Evolutionary biology (1)
- Ewing-like (1)
- Exacerbations (1)
- Examination questions (1)
- Exchange PAINT (1)
- Excitability (1)
- Executive function (1)
- Exemestane (1)
- Exercise Metabolism (1)
- Exercise challenge (1)
- Exercise challenge at an ambient temperature (1)
- Exercise challenge in a cold chamber (1)
- Exercise testing (1)
- Exercise therapy (1)
- Exercise training (1)
- Exercise-induced asthma (1)
- Exercise-induced bronchoconstriction (1)
- Exhaled nitric oxide (1)
- Exitrons (1)
- Exoscope (1)
- Exosomal cytokines (1)
- Expansion (1)
- Expectation violation (1)
- Expedition (1)
- Experimental autoimmune encephalomyelitis (1)
- Expert Systems (1)
- Expertensysteme (1)
- Explicit (1)
- Explorative Data Analysis (1)
- Explorative Datenanalyse (1)
- Exposure (1)
- Expression (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extension study (1)
- External beam radiotherapy (1)
- External-/self-assessment (1)
- Extinction (1)
- Extracellular RNA (1)
- Extracellular RNA (eRNA) (1)
- Extracellular signal-regulated kinase 1/2 (1)
- Extracorporeal circulation (1)
- Extracorporeal devices (1)
- Extracorporeal life support (1)
- Extracorporeal membrane oxygenation (1)
- Extracorporeal purification (1)
- Extrakorporale Dialyse (1)
- Extrakorporaler Kreislauf (1)
- Extraprostatic (1)
- Extreme hypo-fractionation (1)
- Exudates and transudates (1)
- Eye diseases (1)
- Eye tracking (1)
- EyesiNet (1)
- Ezrin (1)
- F 63.8 (1)
- F4/80 (1)
- F508del homozygous (1)
- FAAM (1)
- FABP (1)
- FAK (1)
- FAM134 (1)
- FAM134B (1)
- FAP (1)
- FAPI PET (1)
- FAV00A (1)
- FBK-R23 (1)
- FDG-PET/CT (1)
- FDM (1)
- FECD (1)
- FET (1)
- FF-ATP synthase dimer (1)
- FFF (1)
- FFP3 respirator (1)
- FHIR Search (1)
- FIB-4 (1)
- FIV (1)
- FK506 binding protein (1)
- FLT3 (1)
- FOLFIRI (1)
- FOXO1 (1)
- FOXO3 (1)
- FOXO3a (1)
- FPR (1)
- FREEDOM (1)
- FRET imaging (1)
- FSME-Virus (1)
- FSS (1)
- FTMT (1)
- FX06 (1)
- FXR (1)
- Face masks (1)
- Facet joint osteoarthritis (1)
- Facial nerve (1)
- Factor H (1)
- Factor analysis (1)
- FactorXIII Val34Leu polymorphism (1)
- Faculty Development (1)
- Faktor V Leiden Mutation (1)
- Faktor XIII Val34Leu Polymorphismus (1)
- Faktorstruktur (1)
- Falciparum (1)
- Fall (1)
- Fall Leipzig (Kind Knauer) (1)
- Fall risk (1)
- Fallbeispiele (1)
- Falls (1)
- Familiarity (1)
- Familienanamnese (1)
- Family Physician (1)
- Famines (1)
- Farbmuster (1)
- Farbstoff (1)
- Farbwirkung (1)
- Fascia (1)
- Fasciculus arcuatus (1)
- Fast Healthcare Interoperability Resources (1)
- Fast-track (1)
- Fatigue (1)
- Fatiguesyndrom (1)
- Fatty acids (1)
- Fbw7 (1)
- Fc receptor (1)
- Fear conditioning (1)
- Fear of falling (1)
- Fear of infection (1)
- Fear-invoking (1)
- Fearminimising (1)
- Feasibility studies (1)
- Feature tracking (1)
- Fechner, Gustav Theodor (1)
- Fehler (1)
- Fehlerberichtssystem (1)
- Fehlerberichtssysteme (1)
- Fehlerverhütung (1)
- Fehlstatik (1)
- Feinstaub (1)
- Feline bartonellosis (1)
- FemNAT-CD (1)
- Female (1)
- Female adolescents (1)
- Female subjects (1)
- Females (1)
- Feminismus (1)
- Femoral neck (1)
- Fendrr (1)
- Fenofibrate (1)
- Ferritinophagy (1)
- Ferroptose (1)
- Ferroptosis (1)
- Fertigkeit (1)
- Fertigkeiten (1)
- Fertility counseling (1)
- Fetal bovine serum (1)
- Fetal heart (1)
- Fettleber (1)
- Fever (1)
- Fevers (1)
- Fibertracking (1)
- Fibrinolytic (1)
- FibroMax (1)
- FibroScan (1)
- Fibroblast (1)
- Fibroblast growth factor (1)
- Fibromyalgia (1)
- Fibrose (1)
- Fibrotest (1)
- Fibrous dysplasia (1)
- Fibulin-4 (1)
- Fibulin-5 (1)
- Ficus carica (1)
- Fieberhafter Harnwegsinfekt (1)
- Field of View (1)
- Filariasis (1)
- Filariosis (1)
- Filgrastim (1)
- Filler (1)
- Filovirus cell entry; attachment factors redundancy; SH-SY5Y cell line; host–pathogen interactions (1)
- Finevo (1)
- Finite Element Method (1)
- First experience with patients (1)
- First site of metastatic disease (1)
- First-line combination antiretroviral therapy (1)
- First-line regimen (1)
- Fitness (1)
- Fitnesscenter (1)
- Five-Konzept (1)
- Flaubert, Bouvard und Pécuchet (1)
- Flavin mononucleotide (1)
- Flavivirus (1)
- Flavonoide (1)
- Fleas (1)
- FlexTouch (1)
- Flexible Endoscopic Evaluation of Swallowing (1)
- Flexur (1)
- Flowzytometrie (1)
- Flugzeitmassenspektrometer (1)
- Flugzeitmassenspektrometrie (1)
- Flugzeitspektrometrie (1)
- Fluid overload (1)
- Fluid therapy (1)
- Fluorescence (1)
- Fluorescence imaging (1)
- Fluorescence-in-situ-hybridization (FISH) (1)
- Fluoreszein (1)
- Flüchtlinge (1)
- Flüssigkeitsbeatmung (1)
- Foam rolling (1)
- Focal Adhesion Kinase (1)
- Focal onset seizure (1)
- Folgeerkrankungen (1)
- Folic acid (1)
- Follicular lymphoma (1)
- Follow-up (1)
- Follow-ups (1)
- Fondaparinux (1)
- Food and Drug Administration (1)
- Food and beverage precautions (1)
- Food effects (1)
- Foramen ovale (1)
- Forced expiratory volume in 1 s (1)
- Forensic anthropology (1)
- Forensic examination (1)
- Forensic experts (1)
- Forensic osteology (1)
- Forensic pathology (1)
- Forensics (1)
- Forensische Anthropologie (1)
- Forkhead box (1)
- Formation dance (1)
- Forschung (1)
- Forschungspraxisnetz (1)
- Fortpflanzung (1)
- Foxp1 (1)
- Fracture (1)
- Fracture models (1)
- Fracture risk (1)
- Fracture type (1)
- Fragebogenentwicklung (1)
- Frameshift (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Frankfurt / Zentrum der Rechtsmedizin (1)
- Frankfurt <Main, 1998> (1)
- Frankfurt <Main, Region> (1)
- Frankfurt <Main> / Carolinum, Zentrum der Zahn-, Mund- und Kieferheilkunde (1)
- Frankfurt <Main> / Geographische Gesellschaft (1)
- Frankfurt <Main> / Klinikum (1)
- Frankfurt <Main> / Neurologisches Institut Frankfurt <Main> (1)
- Frankfurt am Main, Universität (1)
- Frankfurt am Main, Universitätsmedizin (1)
- Frankfurt microsurgery course (1)
- Frankfurt, Anatomie (1)
- Frankfurt, Universität (1)
- Frankfurt, Universität, Seminar für Geschichte der Medizin (1)
- Frankfurt, Universitätsmedizin 1933-1945 (1)
- Frankincense (1)
- Frauen (1)
- Frauenkrankheit (1)
- Free energy (1)
- Freibad (1)
- Freiburg im Breisgau <2009> (1)
- Freie Atmung (1)
- Freies Malen mit Alzheimer Kranken (1)
- Fresh frozen plasma (1)
- Freud und die Psychoanalyse (1)
- Frontobasal (1)
- Frontotemporal dementia (1)
- Fruit fly (1)
- Frühgeborenes (1)
- Frühsommermeningoenzephalitis (1)
- Fuctional connectivity (1)
- Fukushima (1)
- Functional ankle instability (1)
- Functional aspects of cell biology (1)
- Functional capacity (1)
- Functional genomics (1)
- Functional mitral regurgitation (1)
- Functional outcome (1)
- Functional outcomes (1)
- Functionally-impaired elderly (1)
- Fungemia/diagnosis (1)
- FungiScope® registry (1)
- Fungämie/Diagnostik (1)
- Funktionelle Bildgebung (1)
- Funktionelle Magnetresonanztomographie (1)
- Funktionelle NMR-Tomographie (1)
- Funktionsdefizite (1)
- Funktionsmorphologie (1)
- Further education (1)
- Fusarium (1)
- Fusion Proteins, BCR-ABL (1)
- Fusion proteins (1)
- Fédération Internationale de Médicine du Sport (FIMS) (1)
- Füllungswerkstoff (1)
- G alpha q (1)
- G protein-coupled receptors (1)
- G-protein (1)
- G-protein coupled receptor (1)
- G-protein-coupled receptors (1)
- G-quadruplex binders (1)
- G/P (1)
- G207 (1)
- G2A receptor (1)
- G3BP (1)
- G3BP1 (1)
- G9a/EHMT2/KMT1C (1)
- GABAergic interneurons (1)
- GABAergic synapse (1)
- GCH1 (1)
- GCN (1)
- GC–MS (1)
- GD2 (1)
- GDF11 (1)
- GFR (1)
- GHQ-28 (1)
- GI pH (1)
- GI solubility (1)
- GIIb/IIIa-receptor (1)
- GILZ (1)
- GIRD (1)
- GLA deficiency (1)
- GLI inhibitors (1)
- GLUT1 (1)
- GLUT2 (1)
- GLUT3 (1)
- GM-CSF (1)
- GMP (1)
- GPR4 (1)
- GPRO (1)
- GPVI (1)
- GRADE (1)
- GRAND-SLAM (1)
- GRK2 (1)
- GRX1-roGFP2 (1)
- GSH (1)
- GSK2334470 (1)
- GSK3α (1)
- GSK3β (1)
- GTP cyclohydrolase (1)
- GTPCH1 (1)
- GVHD (1)
- GVL (1)
- Gaba (1)
- Gadopentate dimeglumine (1)
- Gads (1)
- Galenus (1)
- Gallbladder percutaneous drainage (1)
- Gallengangsstenose (1)
- Gallensäurederivate (1)
- Galleria mellonella (1)
- Galvano (1)
- Games (1)
- Gaming Disorder (1)
- Gamma-Band Activity (1)
- Gamma-aminobutyric acid (1)
- Ganganalyse (1)
- Ganglionic (1)
- Gangstörung (1)
- Ganzheitsbezogenheit (1)
- Ganzheitsmedizin (1)
- Gan–Dou–Fu–Mu decoction (GDFMD) (1)
- Gap junctions (1)
- Gas gangrene (1)
- Gastric adenoma (1)
- Gastric motility (1)
- Gastrocnemius muscles (1)
- Gastroenterology (1)
- Gastroesophageal reflux disease (1)
- Gastroesophageal reflux disease symptoms (1)
- Gastrointestinal cancer (1)
- Gastrointestinal neoplasm (1)
- Gastrointestinal tract (1)
- Gastrointestinaltrakt (1)
- Gaucher disease type III (1)
- Gaucher’s disease (1)
- Gaussian graphical models (1)
- Gebärmutterhalskrebs (1)
- Gedächtnisbelastung (1)
- Gedächtnistraining (1)
- Gefäßinflammation (1)
- Gefäßtonus (1)
- Gegenübertragung (1)
- Gehirn (1)
- Gehörlosigkeit (1)
- Gelastic seizures (1)
- Gelastische Anfälle (1)
- Gemcitabine (1)
- Gemifloxacin (1)
- Genamplifikation (1)
- Genanalyse (1)
- Genauigkeit (1)
- Gender analysis (1)
- Gender equality (1)
- Gender gap (1)
- Gene Polymorphism (1)
- Gene Transfer (1)
- Gene engineering (1)
- Gene expression prediction (1)
- Gene microarray analysis (1)
- Gene polymorphism (1)
- Gene prediction (1)
- Gene regulatory networks (1)
- Gene sequencing (1)
- Gene set analysis (1)
- Gene-Amplification (1)
- Gene-protein assay (1)
- Gene/Regulation (1)
- GeneMANIA (1)
- General Practitioner (1)
- General clinical cardiology (1)
- General cognitive ability (1)
- General dental practice (1)
- General practice/family medicine (1)
- General practitioner (1)
- Generalized procrustes analysis (1)
- Generation Y (1)
- Generation of reports on special findings in laboratory medicine (1)
- Generic drugs (1)
- Genetic causes of cancer (1)
- Genetic heart disease (1)
- Genetic loci (1)
- Genetic networks (1)
- Genetic syndromes (1)
- Genetic techniques (1)
- Genetic transduction (1)
- Genfamilie (1)
- Genitalverstümmelung (1)
- Genklonierung (1)
- Genome annotation (1)
- Genome editing (1)
- Genome-wide association study (1)
- Genomic instability (1)
- Genomic medicine (1)
- Gentransfer (1)
- Geoffrey Burnstock (1)
- Geographical disparities (1)
- Geriatrics (1)
- Geriatrie (1)
- Gerinnungsfaktor IX (1)
- Gerinnungsfaktor VIII (1)
- Gerinnungsfaktor XIII (1)
- Germ aversion (1)
- German PID-NET registry (1)
- German Society of Surgery (1)
- Gerontologic legal medicine (1)
- Gerontologie (1)
- Gerontologische Rechtsmedizin (1)
- Gerontology (1)
- Gesamteiweißbestimmung im Harn (1)
- Gesang (1)
- Geschichte 1663-1748 (1)
- Geschichte 1700-1800 (1)
- Geschichte 1847-1970 (1)
- Geschichte 1867 (1)
- Geschichte 1878 (1)
- Geschichte 1906-1907 (1)
- Geschichte 1914-2014 (1)
- Geschichte 1930-1940 (1)
- Geschichte 1933-1945 (1)
- Geschichte 1938 (1)
- Geschichte 1939-1940 (1)
- Geschichte 1960-1986 (1)
- Geschichte 1972-2002 (1)
- Geschichte 1973-1998 (1)
- Geschichte der Medizin Frankfurt (1)
- Geschichte der Pharmazie (1)
- Geschlechterforschung (1)
- Geschlechtsdysphorie bei Kindern und Jugendlichen (1)
- Geschlechtsidentitätsstörungen im Kindes- und Jugendalter (1)
- Geschwindigkeitsvariation (1)
- Gesellschaftsbild (1)
- Gesetzentwurf (1)
- Gesicht (1)
- Gesicht <Motiv> (1)
- Gesprächsführung (1)
- Gestagen-Monopräparate (1)
- Gestaltwahrnehmung (1)
- Gestational age (1)
- Gestational diabetes (1)
- Gestationshyperthyreose (1)
- Gesundheitliche Ungleichheit (1)
- Gesundheitsamt (1)
- Gesundheitsberichterstattung (1)
- Gesundheitsbildung (1)
- Gesundheitskommunikation (1)
- Gesundheitspersonal (1)
- Gesundheitspolitische Zuständigkeit (1)
- Gesundheitsverhalten (1)
- Gesundheitsversorgungseinrichtungen (1)
- Gesundheitswirtschaft (1)
- Gesundheitswissenschaften (1)
- Get Pathway (1)
- Gewebe-Sauerstoffpartialdruck (1)
- Gewebesauerstoffpartialdruck (1)
- Giant lymph node hyperplasia (1)
- Giftgas (Lost) (1)
- Gimbaled tracking (1)
- Ginkgo biloba (1)
- Ginkgobaum (1)
- Girdlestone (1)
- Glabella (1)
- Gleason Grade Group (1)
- Gleason Grade group (1)
- Gleason Score (1)
- Gleason grade group (1)
- Gleason upgrading (1)
- Glia Maturation Factor (1)
- Glioblastoma survival (1)
- Gliom (1)
- Glivec® (1)
- Global Alignment (1)
- Global Health (1)
- Global Health Ethics (1)
- Global Justice (1)
- Global networking (1)
- Global protein synthesis rates (1)
- Global warming (1)
- Glomerular Filtration Rate (1)
- Glomerular diseases (1)
- Glomerulonephritis (1)
- Glomerulosclerosis (1)
- Glomerulus (1)
- Glucocorticoids (1)
- Glucose Transporter Type 1 (1)
- Glucose tolerance test (1)
- Glucosetoleranztest (1)
- Glukose (1)
- Glutamatrezeptor (1)
- Glycinrezeptor (1)
- Glycogen synthase kinase 3 beta (1)
- Glycosphingolipids (1)
- Glyoxalase I (1)
- Glücksspielstörung (1)
- Goal-oriented care (1)
- Gold (1)
- Gonarthrose (1)
- Goserelin (1)
- Gradient boosting (1)
- Grading (1)
- Grado en medicina (1)
- Graft (1)
- Graft function (1)
- Graft quality (1)
- Graft survival (1)
- Gram negative bacteria (1)
- Gram-negative bacteria (1)
- Gram-positive Bakterien ; Linezolid ; Arzneimittelresistenz (1)
- Gram-positive Bakterien ; Moxifloxacin ; Arzneimittelresistenz (1)
- Gram-positive infection (1)
- Grammatical Aspect (1)
- Grammatik (1)
- Granger causality (1)
- Granule cell (1)
- Granulocytes (1)
- Graph database (1)
- Graph theory (1)
- Graphentheorie (1)
- Graphical LASSO (1)
- Grass pollen (1)
- Graves' (1)
- Graves’ disease (1)
- Gravimetric method (1)
- Gray matter (1)
- Gray matter volume (1)
- Graz <2013> (1)
- Greater tuberosity fractures (1)
- Green Tobacco Sickness (GTS) (1)
- Green infrastructure (1)
- Greenhouse effect (1)
- Grenzwert (1)
- Grenzüberschreitung (1)
- Griechenland <Altertum> (1)
- Grip force (1)
- Groddeck, Georg (1)
- Groin pain (1)
- Gross tumor volume optimization (1)
- Grossesse (1)
- Growth cone (1)
- Growth factor (1)
- Growth factor signalling (1)
- Großhirnrinde (1)
- Grundschule (1)
- Grüne Meerkatze ; Immundefekt ; Virusinfektion ; Resistenz (1)
- Guanylatzyklasen (1)
- Guanylyl cyclases (1)
- Guidance (1)
- Guide profession (1)
- Guided bone regeneration (GBR) (1)
- Guided surgery (1)
- Guided tissue regeneration (1)
- Guided tissue regeneration (GTR) (1)
- Guideline adherence (1)
- Guideline-based treatment (1)
- Guinea-Bissau (1)
- Gut (1)
- Gut bacteria (1)
- Gut-liver-axis (1)
- GvHD (1)
- GvL (1)
- Gynäkologie (1)
- Gyrasehemmer (1)
- Görden, Anstalt (1)
- Götter (1)
- Güntz, Eduard (1)
- Gütt, Arthur (1)
- H-Index (1)
- H/M ratio (1)
- H3 receptor (1)
- H5N1 (1)
- HACA (1)
- HADS (1)
- HAEGARDA (1)
- HAI‐1 (1)
- HARS2 (1)
- HBV filaments (1)
- HBV genotypes (1)
- HBV reactivation (1)
- HBV surface protein (1)
- HCC marker (1)
- HCC recurrence (1)
- HCMV-Retinitis (1)
- HCV treatment (1)
- HCV-Core-Antigen (1)
- HDAC and BET inhibitor (1)
- HDAC inhibition (1)
- HDAC inhibitor (1)
- HDAC-inhibition (1)
- HDAC4 (1)
- HDR-Brachytherapie (1)
- HDR-brachytherapy (1)
- HEOR (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (ERBB2) (1)
- HERV (1)
- HEUS (1)
- HEV (1)
- HFrEF (1)
- HGF (1)
- HH (1)
- HHUSD (1)
- HHV-8 (1)
- HIBCPP cells (1)
- HIF-1 (1)
- HIF-1α (1)
- HIF-2 (1)
- HIF-2α (1)
- HIF-2α, erythropoietin (1)
- HIF1α (1)
- HIFT (1)
- HIFU (1)
- HILI (1)
- HIPPO signalling (1)
- HIT (1)
- HIV ; Genetische Variabilität ; Immunoassay (1)
- HIV Humanized Mice (1)
- HIV pre-exposure prophylaxis (1)
- HIV prevention technologies (1)
- HIV serodiagnosis (1)
- HIV therapy (1)
- HIV-1 Genotypisierung (1)
- HIV-1 escape restriction (1)
- HIV-1 genotyping (1)
- HIV-Antigen-Test (1)
- HIV-Infektionen (1)
- HIV-Infizierter (1)
- HIV-RNA (1)
- HIV-infected patient (1)
- HIV-infection (1)
- HLA DQ haplotypes (1)
- HLA DQB1 (1)
- HLA antibodies (1)
- HLA class I loss (1)
- HLA class II (1)
- HLA peptidome (1)
- HLHS (1)
- HMA (1)
- HMGB1 (1)
- HNPCC (1)
- HODE (1)
- HOLEP (1)
- HOSO (1)
- HOTAIR (1)
- HOXA profile (1)
- HOXB4 (1)
- HPO (1)
- HPV infection (1)
- HPV-positive OPSCC (1)
- HRAS 28 Gefitinib (1)
- HRCT (1)
- HRV (1)
- HRas (1)
- HSC (1)
- HSP (hereditary spastic paraplegia) (1)
- HSP90 inhibitors (1)
- HSPC (1)
- HSV type specific antibodies (1)
- HSV-2 (1)
- HSV-typenspezifische Antikörper (1)
- HVPG (1)
- Haaranalyse (1)
- Habits (1)
- Hadamar (1)
- Haematocrit (1)
- Haematologic diseases (1)
- Haematoma expansion (1)
- Haematopoietic stem cells (1)
- Haemodialysis (1)
- Haemodynamic monitoring (1)
- Haemophilia (1)
- Haemophilie A (1)
- Haemostatics (1)
- Hals (1)
- Hamburg <2014> (1)
- Hand-foot syndrome (1)
- Handlungsanweisungen (1)
- Hantavirus (1)
- Haploidentical stem cell transplantation (1)
- Haplotypes (1)
- Hard-tissue trauma (1)
- Hard-to-reach population (1)
- Hardware erosion (1)
- Harnsteinanalyse (1)
- Harnsteinkomponenten (1)
- Hashimoto (1)
- Hashimoto Thyreoiditis (1)
- Hashimoto’s thyroiditis (1)
- Hautbarriere (1)
- Hautlokalisation (1)
- Hautoberflächentemperatur (1)
- Hawaii Department of Health (1)
- Hazard assessment (1)
- HbA1c (1)
- Head and neck Cancer (1)
- Head bandage (1)
- Head injury (1)
- Head neck cancer (1)
- Health Communication (1)
- Health Policy (1)
- Health Systems (1)
- Health care access (1)
- Health care resource utilization (1)
- Health care sector (1)
- Health care structures (1)
- Health education and awareness (1)
- Health facilities (1)
- Health information (1)
- Health literacy (1)
- Health personnel (1)
- Health research (1)
- Health risk analysis (1)
- Health sciences (1)
- Health services research [MeSH] (1)
- Health surveys (1)
- Health technology assessment (1)
- Health workforce governance (1)
- Health-related quality of life (1)
- Health-seeking behaviour (1)
- Healthcare (1)
- Healthcare resource utilisation (1)
- Healthcare structure (1)
- Healthy Living Index (HLI) (1)
- Healthy men (1)
- Healthy stem cell donors (1)
- Health‐related quality of life (1)
- Heart defects (1)
- Heart regeneration (1)
- Heartrate (1)
- Heat Shock Protein (HSP) (1)
- Heat pain (1)
- Heat shock protein 27 (1)
- Hebbian plasticity (1)
- Heben (1)
- Hedgehog (1)
- Hedgehog pathway (1)
- Heiler (1)
- Heilung (1)
- Heimtraining (1)
- Heinz-Jürgen Voss (1)
- Helpline (1)
- Hemagglutination inhibition assay (1)
- Hematocrit value (1)
- Hematologic adverse events (1)
- Hematoma (1)
- Hematopoietic stem and progenitor cells (HSPCs) (1)
- Hematopoietic stem cell (1)
- Hematopoietic stem cell transplant (1)
- Hematopoietic stem cell transplantation (1)
- Hematopoietic stem cells (1)
- Hematotoxicity (1)
- Hematoxylin staining (1)
- Heme-Oxygenase 1 (1)
- Hemikraniektomie (1)
- Hemispheric specialization (1)
- Hemobilia (1)
- Hemodialyse (1)
- Hemodilution (1)
- Hemodynamic management (1)
- Hemoglobin (1)
- Hemophilia A (1)
- Hemorrhagic shock (1)
- Hemosiderin (1)
- Hemostasis (1)
- Hemostatics (1)
- HepG2 Zellen (1)
- Heparan Sulfate (1)
- Heparin (1)
- Heparinsensitivität (1)
- Hepatectomy (1)
- Hepatic encephalopathy (1)
- Hepatic stellate cell (1)
- Hepatitis B Antibodies/serum (1)
- Hepatitis B Core-Antigene/Immunologie (1)
- Hepatitis B infection (1)
- Hepatitis B vaccination (1)
- Hepatitis B-Antikörper/Serum (1)
- Hepatitis B-Core-Antigens-immunology (1)
- Hepatitis C antibodies (1)
- Hepatitis C antigens (1)
- Hepatitis C, Chronic (1)
- Hepatitis C-Virus (HCV) (1)
- Hepatitis C; DNA (1)
- Hepatitis G virus (1)
- Hepatitis G-Virus (1)
- Hepatitis c (1)
- Hepatitis, Chronic Active/diagnosis (1)
- Hepatoblastom (1)
- Hepatocellular carcinoma (HCC) (1)
- Hepatocytes (1)
- Heptazelluläres Karzinom (1)
- Her2-neu (1)
- Herafill (1)
- Herbal medicine (1)
- Herbalife (1)
- Herbalife products (1)
- Herbs (1)
- Herbs induced liver injury (1)
- Herd immunity (1)
- Hereditary breast and ovarian cancer (1)
- Hereditary breast cancer (1)
- Hereditary ovarian cancer (1)
- Hereditäre Thrombophilie (1)
- Heregulin (1)
- Hernia recurrence (1)
- Hernia surgery (1)
- Herniated disk (1)
- Herpe-Viren (1)
- Herpes Simplex Virus Type 1 (HSV-1) (1)
- Herpes Simplex Virus/isolation and purification . (1)
- Herpes genitalis (1)
- Herpes simplex (1)
- Herpes simplex Virus Typ 1 (1)
- Herpes simplex Virus Typ 2 (1)
- Herpes simplex Virus/Isolierung und Anreicherung (1)
- Herpes simplex virus type 1 (1)
- Herpes simplex virus type 2 (1)
- Herpes virus (1)
- Herpesvirus 1, Humanes (1)
- Herpesvirus 2, Human (1)
- Herpesvirus 2, Humanes (1)
- Herpesvirus1, Human (1)
- Herz-Kreislauffunktion (1)
- Herzchirurgie (1)
- Herzindex (1)
- Herzkatheteruntersuchung (1)
- Heterologous prime-boost (1)
- Heterotopic pregnancy (1)
- Heterozyklen (1)
- Heuristik (1)
- Hexavalent vaccine (1)
- HhAntag (1)
- HiC (1)
- HiChIP (1)
- Hidradenitis suppurativa (1)
- Hierarchical drift-diffusion modeling (1)
- Hif-1 alpha (1)
- Hif1α (1)
- Hig1 (1)
- High altitude (1)
- High performance liquid chromatography (1)
- High radon areas (1)
- High-dose chemotherapy (1)
- High-income countries (1)
- High-intensity interval endurance training (1)
- High-resolution (1)
- High-risk cardiac surgery (1)
- High-risk patient (1)
- High-risk prostate cancer (1)
- High-throughput screening (1)
- Highly infectious diseases (1)
- Highwire (1)
- Himalayas (1)
- Hindu Kush Himalayas (1)
- Hip (1)
- Hip hemiarthroplasty (1)
- Hip revision (1)
- Hippo signaling (1)
- Hippocampal excitability (1)
- Hippocampal subfields (1)
- Hippocampal volume (1)
- Hippokrates, Asteroid (1)
- Hirnkrankheit (1)
- Hirnmetastasen (1)
- Hirnverletzung (1)
- Hirschsprung disease (1)
- Hirt, August (1)
- Hispanic people (1)
- Hispanic–Latino race/ethnicity (1)
- Histological analysis (1)
- Histone post-translational modifications (1)
- Histonmethylierung (1)
- Histoplasma qPCR (1)
- History (1)
- History of medicine (1)
- Hitachi 705 (1)
- HlV-Infections (1)
- Hmox1 (1)
- Hochansteckende Krankheiten (1)
- Hochdurchsatz (1)
- Hochfrequenz-Katheterablation (1)
- Hochschuldidaktik (1)
- Hodgkin-Lymphom (1)
- Hodgkin’s lymphoma (1)
- Holmium laser enucleation (1)
- Holzhausen (1)
- Home Care Services [MeSH] (1)
- Homeostatic plasticity (1)
- Hometraining (1)
- Homicide-suicide (1)
- Homizid-Suizid (1)
- Homocysteine (1)
- Homonationalismus (1)
- Honolulu Queen’s Medical Center (1)
- Hormonal (1)
- Hormone (1)
- Hormone de régression müllérienne (1)
- Hormone receptor positive breast cancer (1)
- Hormonelle Kontrazeptiva (1)
- Hormones thyroïdiennes (1)
- Horner's syndrome (1)
- Horner-Emmons-Reaktion (1)
- Hornhauttransplantation (1)
- Horses (1)
- Hospital Governance (1)
- Hospital case volume (1)
- Hospitalization (1)
- Hospitalizations (1)
- Host-directed therapies (1)
- Host-targeting agents (HTAs) (1)
- Hounsfield units (1)
- Hounsfieldeinheit (1)
- House dust mite allergy (1)
- Household contacts (1)
- Hrvaška (1)
- Hsp70 (1)
- Hsp90 inhibitor (1)
- Huh7 (1)
- Human Immunodeficiency Virus (1)
- Human chorionic villi mesenchymal stromal cells (1)
- Human experimental pain models (1)
- Human health (1)
- Human immunodeficiency virus (HIV) (1)
- Human olfaction (1)
- Human pancreas (1)
- Human physiology (1)
- Human primary proximal tubular cells (1)
- Human prostate (1)
- Human retroelements (1)
- Human visual cortex (1)
- Human well-being (1)
- Humangenetik (1)
- Humankapital (1)
- Humans (1)
- Humanwissenschaften (1)
- Humeral fractures (1)
- Humerus (1)
- Humerus fracture (1)
- Humerusfraktur (1)
- Hungary (1)
- Huntington (1)
- Hyaluronan (1)
- Hydratation der Epidermis (1)
- Hydrocephalus (1)
- Hydrocortison (1)
- Hydrocortisone (1)
- Hydrodynamik (1)
- Hydrofluoric acid (1)
- Hydrogen bonding (1)
- Hydrolyse (1)
- Hydromineral (1)
- Hydroxyapatite (1)
- Hydroxychloroquine (1)
- Hydroxycut (1)
- Hydroxyethyl starch (1)
- Hydroxyurea (1)
- Hygienestandards (1)
- Hymenoptera venom allergy (1)
- Hymenoptera venom immunotherapy (1)
- Hyperactivity (1)
- Hyperammonemic encephalopathy (1)
- Hyperbare Oxygenation (HBO) (1)
- Hypercholesterinämie (1)
- Hypercolumn (1)
- Hyperhidrosis axillaris (1)
- Hyperlipidemia (1)
- Hyperlipidämie (1)
- Hyperscanning (1)
- Hypertensive disorders in pregnancy (1)
- Hypertext (1)
- Hyperthyroïdie gestationnelle (1)
- Hypofractionated radiotherapy (1)
- Hypokalzämie (1)
- Hyponatremia (1)
- Hypoparathyreoidismus (1)
- Hyposensibilisierung (1)
- Hypothyreose (1)
- Hypothyroïdie (1)
- Hypoxia inducible factor (1)
- Hypoxia inducible factor 1 alphal (1)
- Hypoxia-inducible factor-1α (HIF-1α) (1)
- Hypoxic responses (1)
- Hypoxie (1)
- Hysterektomie-Prävalenz (1)
- Häm-Oxygenase 1 (1)
- Hämatotoxizität (1)
- Hämodynamik Shunt (1)
- Hämophile Arthropathie (1)
- Hämophilie (1)
- Händehygiene (1)
- Hôpital de la Salpêtrière (1)
- Höchstrichterliche Rechtsprechung (1)
- Höhren (1)
- Hörscreening (1)
- Hüftgelenkprothese (1)
- I-FABP (1)
- I-PRF (1)
- IAP (1)
- IAP Proteins (1)
- IAP-IAP (1)
- ICAM-1 (1)
- ICG (1)
- ICH M13A draft guideline (1)
- ICL (1)
- ICL V4c (1)
- ICSD (1)
- ICSI (1)
- IDH1 inhibitor (1)
- IDO1 (1)
- IDT (1)
- IFA (1)
- IFN (1)
- IFN-y (1)
- IFN-β (1)
- IFN-γ expression (1)
- IFN-γ neutralization (1)
- IGF (1)
- IGF-1 (1)
- IGF1 (1)
- IGRA (1)
- IKKε (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- IL-11 (1)
- IL-13 (1)
- IL-15 (1)
- IL-17 (1)
- IL-17A (1)
- IL-18 (1)
- IL-18 binding protein (1)
- IL-18BP (1)
- IL-18BPa (1)
- IL-1b (1)
- IL-21 (1)
- IL-22 (1)
- IL-23 (1)
- IL-27 cytokine (1)
- IL-38 (1)
- IL-6 neutralization (1)
- IL10R (1)
- ILUVIEN (1)
- IMiD® (1)
- ING (1)
- INR (1)
- IPEX (1)
- IPP (1)
- IPS (1)
- IPS e.max system (1)
- IPSS (1)
- IR (1)
- IRES translation (1)
- IRF-3 (1)
- IRIS (1)
- IRX1 (1)
- ISO (1)
- ISRS (1)
- ISS (1)
- ITGA7 (1)
- IUIS classification 2017 (1)
- IV iron (1)
- IVA interference tandem mass spectrometry (1)
- IVD (1)
- IVD degeneration (IVDD) (1)
- IVD directive (1)
- IVD-Richtlinie (1)
- IVDU (1)
- IVF (1)
- IVIV_E (1)
- IVUS (1)
- Iatrochemie (1)
- Iatrochemistry (1)
- Iatrogen (1)
- Iatrogenic (1)
- Iceland (1)
- Idarucizumab (1)
- Idelalisib (1)
- Identifier (1)
- Identifikation (1)
- Identifizierung von Katastrophenopfern (1)
- Identity (1)
- Identität (1)
- Idiopathic pain (1)
- Idiopathic pulmonary fibrosis (IPF) (1)
- Idiopathische Dystonie (1)
- Ig (sub)class-specific antibody determination (1)
- Ig- (sub)klassen-spezifische Antikörperbestimmung (1)
- IgA deficiency (1)
- IgE (1)
- IgG (1)
- IgG substitution therapy (1)
- IgG4-related disease (1)
- IgGAM (1)
- IgM/Immunologie (1)
- IgM/immunology (1)
- Ileostomy (1)
- Illumina (1)
- Illustration (1)
- Image processing (computer-assisted) (1)
- Imagery (1)
- Imaging (1)
- Imaging genetics (1)
- Imaging in LGG (1)
- Imaging, three-dimensional (1)
- Imatinib (1)
- Imdevimab (1)
- Immediate loading (1)
- Immediate placement (1)
- Immobilization (1)
- Immunbiology (1)
- Immune Complexes (1)
- Immune checkpoint inhibitors (1)
- Immune complex vasculitis (1)
- Immune evasion (1)
- Immune paralysis (1)
- Immune receptor signaling (1)
- Immune response (1)
- Immune status (1)
- Immunfixations-Elektrophorese (1)
- Immunglobulinklassen und -subklassen (1)
- Immunhyperthyreose (1)
- Immunität (Medizin) (1)
- Immunitätsbeurteilung (1)
- Immunkompetenz (1)
- Immunkomplexe (1)
- Immunnephelometrie (1)
- Immunoassay (1)
- Immunoassays (1)
- Immunochemistry (1)
- Immunocompromised (1)
- Immunodeficiency (1)
- Immunofluoreszenz (1)
- Immunogenetics (1)
- Immunoglobulin Therapy (1)
- Immunoglobulin classes and -subclasses (1)
- Immunoglobulins (1)
- Immunohistochemistry techniques (1)
- Immunologic methods (1)
- Immunological techniques (1)
- Immunologie Methods (1)
- Immunologische Diagnostik (1)
- Immunology and Microbiology Section (1)
- Immunomagnetische Antikörper (1)
- Immunomodulation (1)
- Immunomodulatory agents (1)
- Immunomonitoring (1)
- Immunonephelometry (1)
- Immunophenotyping (1)
- Immunosenescence (1)
- Immunoseneszenz (1)
- Immunostaining (1)
- Immunosuppressive Agents (1)
- Immunosuppressive agents (1)
- Immunosuppressive therapy (1)
- Immunoturbidimetry (1)
- Immuno‑histochemistry (1)
- Immunreaktion (1)
- Immunrekonstitution (1)
- Impedanzaggregometrie (1)
- Impella (1)
- Impfkurs (1)
- Impfquoten (1)
- Implant osseointegration (1)
- Implant-supported bars (1)
- Implantable cardioverter-defibrillator (1)
- Implantat (1)
- Implantatverfahren (1)
- Implementación (1)
- Implicit (1)
- Implicit Processing (1)
- Implicit Association Test (1)
- Implicit motives (1)
- Impoverishment (1)
- Impräzision (1)
- Impulse control (1)
- Impulse generator (1)
- Imrt (1)
- In situ (1)
- In situ hybridization (1)
- In vitro wound models (1)
- In vivo electrophysiology (1)
- In-ASK Studie (1)
- In-Hospital Emergencies (1)
- In-TIPS thrombosis (1)
- In-hospital cardiac arrest (1)
- In-line filtration (1)
- In-vitro-Kultur (1)
- In-vivo (1)
- Inactivation (1)
- IncL (1)
- IncX (1)
- Incident reporting system (1)
- Incidental prostate cancer (1)
- Incomplete colonoscopy (1)
- Incontinence (1)
- Independent component analysis (1)
- Independent laboratories (1)
- Indeterminate biliary stricture (1)
- Index (1)
- India (1)
- Indication (1)
- Indication for fertility preservation (1)
- Indirect treatment comparison (ITC) (1)
- Individual differences (1)
- Individualisierung des Studiums (1)
- Individualized intervention (1)
- Individualized therapy (1)
- Individuelle Studienbegleitung (1)
- Indocyanine green (1)
- Indoles (1)
- Indoor air pollution (1)
- Induced membrane technique (1)
- Induced pluripotent stem cells (1)
- Induced sputum (1)
- Inducible nitric oxide synthase (iNOS) (1)
- Induction therapy (1)
- Induratio penis plastica (1)
- Inequality (1)
- Inertial motion capture (1)
- Infant (1)
- Infant leukemia (1)
- Infants (1)
- Infarction (1)
- Infectious disease (1)
- Infectious disease epidemiology (1)
- Infektionen (1)
- Infektionskrankheit (1)
- Infektionskrankheiten (1)
- Infektionsprophylaxe (1)
- Inferior colliculus (1)
- Inferior vena cava thrombus (1)
- Infertilität (1)
- Inflammasome (1)
- Inflammatory Bowel Disease (1)
- Inflammatory fibroid polyp (1)
- Inflammatory pain (1)
- Inflammatory pattern (1)
- Infliximab (1)
- Inflow obstruction (1)
- Influenza Virus (1)
- Influenza vaccination (1)
- Influenza virus (1)
- Information transfer (1)
- Informiertheit (1)
- Infrared Raman (1)
- Infrarot-A-Strahlung (IRA) (1)
- Infrarot-Ganzkörperhyperthermie (1)
- Infrarotspektroskopie (1)
- Infusion management (1)
- Inguinal hernia (1)
- Inguinal pain (1)
- Inherited arrhythmic syndrome (1)
- Injection therapy (1)
- Injektionstherapie (1)
- Injury Severity Score (ISS) (1)
- Innate immune system (1)
- Inner ear therapy (1)
- Inpatient hospital cases (1)
- Inpatients (1)
- Insekten (1)
- Instructions for action (1)
- Insula (1)
- Insulin resistance (1)
- Insulin secretion (1)
- Insulin therapy (1)
- Insulintherapie (1)
- Integrated Pulmonary Index (1)
- Integrated multimodal training (1)
- Integrationsversorgung/integrierte ambulante Versorgung (1)
- Integrative Network Analysis (1)
- Intelligence tests (1)
- Intensive care outcome (1)
- Intensive care unit (1)
- Intensivmedizin (1)
- Intensivpatient (1)
- Intention attribution (1)
- Inter-areal coherence (1)
- Inter-study reproducibility (1)
- Interaction (1)
- Interaktionsdatenbanken (1)
- Interferon alpha (1)
- Interferon response (1)
- Interferon-free (1)
- Interferon-free HCV treatment (1)
- Interferon-frei (1)
- Interferon-α (1)
- Interferon-λ, (1)
- Interferonfrei (1)
- Interferons (1)
- Interleukin-10 (1)
- Interleukin-17A (1)
- Interleukin-18 (1)
- Interleukin-18 binding protein (1)
- Interleukin-22 binding protein (1)
- Interleukin-36 (1)
- Interleukine (1)
- Intermediate filaments (1)
- Intermediate-risk (1)
- International body passport (1)
- International normalized ratio (1)
- Internationale Wettbewerbsfähigkeit (1)
- Internationaler Vergleich (1)
- Internationaler Wettbewerb (1)
- Internet (1)
- Internet Gaming Disorder (1)
- Internet gaming disorder (1)
- Internet technology (1)
- Internet use disorders (1)
- Internet-based therapy (1)
- Internetabhängigkeit (1)
- Internetbezogene Störungen (1)
- Internettechnologie (1)
- Interoperability (1)
- Interposition (1)
- Interpretation Bias (1)
- Interrater Reliability (1)
- Interraterreliabilität (1)
- Intersectoral care (1)
- Interspecific competition (1)
- Interstitial lung diseases (ILD) (1)
- Interstitial pneumonia (1)
- Intervention development (1)
- Interventional Trials (1)
- Interventional cardiology (1)
- Interventional oncological treatment (1)
- Intervertebral disc degeneration (1)
- Intervertebral disc displacement (1)
- Interview (1)
- Interviews (1)
- Intestinal failure-associated liver disease (1)
- Intestinal fistula (1)
- Intestinal metaplasia (1)
- Intestinal neoplasms (1)
- Intestinale bakterielle Fehlbesiedelung (1)
- Intimal-medial thickness (1)
- Intimchirurgie (1)
- Intolerance (1)
- Intoxication (1)
- Intoxikation (1)
- Intra-abdominal infection (1)
- Intrabody (1)
- Intracellular Trafficking (1)
- Intracellular pathogens (1)
- Intracellular pathways (1)
- Intracerebral haemorrhage (1)
- Intracerebroventricular (1)
- Intracranial embolism (1)
- Intracranial haemorrhage (1)
- Intracranial hemorrhage (1)
- Intragastric balloon (1)
- Intraoperative blood salvage (1)
- Intraoperative procedure (1)
- Intraoperative test (1)
- Intraoral scanners (1)
- Intraosseous access (1)
- Intratumoral (1)
- Intratympanic drug delivery (1)
- Intravenous Drug User (1)
- Intravenous antibiotic therapy (1)
- Intravenous antiepileptics (1)
- Intravenous injections (1)
- Intravenous iron (1)
- Intravenöse Antiepileptika (1)
- Intrinsic Disorder (1)
- Intrinsic resistance (1)
- Intubation (1)
- Intubation anesthesia (1)
- Intubationsnarkose (1)
- Invasive candidiasis (1)
- Invasive fungal infection (1)
- Invasive fungal infections (1)
- Invasive mosquitoes (1)
- Invasive species (1)
- Inventory of Callous–Unemotional Traits (1)
- Invisible boundary paradigm (1)
- Inzidenzkorrektur (1)
- Iod (1)
- Iodmangel (1)
- Ion channels in the nervous system (1)
- Ionenkanal (1)
- Ionentransport ; Anion ; Sarkoplasmatisches Retikulum (1)
- Ipilimumab (1)
- Ireb2 (1)
- Ireland (1)
- Iridium-192 (1)
- Iron Overload (1)
- Iron chelation (1)
- Iron estimation (1)
- Iron oxides (1)
- Irregular vaccination (1)
- Ischemia-reperfusion injury (1)
- Ischemia–reperfusion injury (1)
- Ischemic stroke (1)
- Ischämie (1)
- Islam (1)
- Islamethik (1)
- Isocitrate dehydrogenase (1)
- Isoflurane (1)
- Isoforms (1)
- Isolation, separation and purification (1)
- Isoliert-perfundierte Rattenherzen (1)
- Isolierung (1)
- Isolierung <Medizin> (1)
- Isothermal Titration Calorimetry (ITC) (1)
- Isothermal amplification (1)
- Isotope labeling (1)
- Issue 96 (1)
- Italy (1)
- Itpr1 (1)
- Ivor Lewis esophagectomy (1)
- JAK inhibition (1)
- JAK2V617F (1)
- JAWSTAT pathway (1)
- JNK (1)
- JNK3 (1)
- Jak2(V617F) (1)
- Java <Programmiersprache> (1)
- Jaw surgery (1)
- JawsII (1)
- Job satisfaction (1)
- Jodausscheidung im Urin (1)
- John Taylor (1)
- Joint actions (1)
- Joint destruction (1)
- Joubert syndrome (1)
- Jugend (1)
- Jugendliche (1)
- Jugendlicher (1)
- Julia (1)
- Jurkat (1)
- Juvenile myoclonic epilepsy (1)
- Jüdische Dozenten Frankfurt (1)
- K-homology RNA-binding domain (1)
- K3EDTA plasma sampling (1)
- KAP (1)
- KATP-Kanal Blocker (1)
- KCCQ (1)
- KCGS (1)
- KCNJ2 mutation (1)
- KCNQ1 (1)
- KCNQ4 (1)
- KDIGO (1)
- KIF (1)
- KIF11 (1)
- KIR (1)
- KLHL11 (1)
- KLK5 (1)
- KMT2A (1)
- KOOS IV (1)
- KPS (1)
- KRAS (1)
- KSHV epidemiology (1)
- KSHV, Epidemiologie (1)
- Kachexie (1)
- Kaiserschnitt (1)
- Kaisidis plate (1)
- Kaliumkanal ; Inhibition ; Herzmuskelzelle (1)
- Kallestad QM 300 (1)
- Kallestad QM 30 (1)
- Kallikrein inhibitor (1)
- Kalorienverbrauch (1)
- Kandidatengen (1)
- Kanzlei des Führers (1)
- Kapazitätsdefizit (1)
- Kapitalismus (1)
- Kaplan-Meier-Schätzung (1)
- Kapnographie (1)
- Kappa (1)
- Kardiomyopathie (1)
- Kardiovaskuläres Risiko (1)
- Karies (1)
- Karotte (1)
- Karyotypes (1)
- Karzinom (1)
- Karzinomzellen (1)
- Katamnese Transidentität im Kindes- und Jugendalter (1)
- Kataraktchirugie (1)
- Katheterablation (1)
- Kava (1)
- Kava hepatotoxicity (1)
- Kavitätenpräparation (1)
- Keap1-Nrf2 (1)
- Kephalometrie mit Magnetinduktion (1)
- Kephalometrie ohne Röntgenstrahlen (1)
- Keratinocytes (1)
- Keratoplastik (1)
- Ketogenic Diet (1)
- Ketolide (1)
- Key stone species (1)
- Ki-67/MIB1 (1)
- Ki67 transgenic c‐myc/TGFα mice (1)
- Kidney (1)
- Kidney Transplantation (1)
- Kidney disease (1)
- Kidney diseases (1)
- Kidney neoplasm (1)
- Kidney transplant recipients (1)
- Kidneys (1)
- Kiefer (1)
- Kieferhöhlenentzündung (1)
- Kif15 mRNA (1)
- Kim-1 (1)
- Kinase inhibitors (1)
- Kinder und Jugendliche (1)
- Kinderchirurgie (1)
- Kindergarten (1)
- Kindersterblichkeit (1)
- Kindertagesstätten (1)
- Kindes- und Jugendalter (1)
- Kindesalter (1)
- Kindestötung (1)
- Kindheit (1)
- Kinds of diseases (1)
- Kindspech (1)
- Kinematic posture analysis (1)
- Kinematics (1)
- Kinematik (1)
- Klavierspiel (1)
- Kleinkind (1)
- Klinische Fertigkeiten (1)
- Knee joint (1)
- Knee joint sound (1)
- Knee osteoarthritis (1)
- Knee surgery (1)
- Kniegelenkarthrose (1)
- Kniegelenkinfekt (1)
- Knieinfekt (1)
- Knochenabbau (1)
- Knochendefektheilung (1)
- Knochenevaluation (1)
- Knochenmarksmikromilieu (1)
- Knochenmetastasen (1)
- Knockout (1)
- Koch (1)
- Koch, Richard (1)
- Kodieralgorithmus (1)
- Kognitiv (1)
- Kognitive Beeinträchtigungen (1)
- Kognitiver Prozess (1)
- Kombinationstherapie (1)
- Kombinationstherapien (1)
- Kommerzialisierung (1)
- Kommerzielle Immunglobuline (1)
- Komorbiditäten (1)
- Komplementbindungsreaktion (KBR) (1)
- Komplikation allogene Stammzelltransplantation (1)
- Komplikationsrate (1)
- Komposit (1)
- Komprimierte Abtastung (1)
- Konformitätsbewertung (1)
- Kongo <Demokratische Republik> (1)
- Kongress <Wandlitz, 1997> (1)
- Konsens (1)
- Konsensus Methode (1)
- Kontaktallergie (1)
- Kontrastmittel (1)
- Kontrazeption (1)
- Kontroll- und Regressmechanismen (1)
- Kontrollierte klinische Studie (1)
- Konusprothese (1)
- Konversion (1)
- Konzeption (1)
- Konzeptpapier (1)
- Koordination (1)
- Kopf (1)
- Kopfhaar (1)
- Kopfstimme (1)
- Koronare Herzkrankheit (1)
- Koronarfluss (1)
- Korporatismus (1)
- Korporativer Staat (1)
- Korrektheit (1)
- Kortikale Dicke (1)
- Kortikotrope Achse (1)
- Kosmetische Chirurgie (1)
- Kosten-Nutzen-Analyse (1)
- Koti (1)
- Krait (1)
- Kraniomandibuläre Dysfunktion (1)
- Krankengymnastik (1)
- Krankenhaus (1)
- Krankenhausfallaufkommen (1)
- Krankenhausfinanzierung (1)
- Krankenhausinformationssystem (1)
- Krankheitsbegriff (1)
- Krankheitskosten (1)
- Krankheitsverlauf (1)
- Kreatinin (1)
- Krebs (Medizin) (1)
- Krebs <Medizin> (1)
- Krebsfamiliensyndrom (1)
- Krebsforschung (1)
- Krebststammzelle (1)
- Krieg (1)
- Kriminalität (1)
- Kryokonservierung (1)
- Kultur (1)
- Kunsttherapie für Menschen mit vaskulärer Demenz (1)
- Kupfer (1)
- Kupferstich (1)
- Kupffer cells (1)
- Kurzzeitgedächtnis (1)
- Kutner, Luis (1)
- Kynurenine (1)
- Kölner Deklaration (1)
- Körperbild (1)
- Körpergrößenschätzung, Geschlechtsdiskrimination (1)
- Körperliche Belastung (1)
- Körpermaße (1)
- Körpermodifizierung (1)
- Körpersoziologie (1)
- Künste (1)
- L1 cell-adhesion molecule (L1-CAM) (1)
- L1-norm SVM (1)
- LABAs (1)
- LAMP3 (1)
- LAMTOR1 (1)
- LAMTOR2 (1)
- LARS2 (1)
- LASP1 (1)
- LASS (1)
- LAT (1)
- LBP (1)
- LC-MS (1)
- LC-MS-Based Clinical Research (1)
- LC-MS-based lipid mediator analysis (1)
- LC-NE system (1)
- LC3 I/II (1)
- LC3B (1)
- LCD-Array (1)
- LCH (1)
- LC–MS/MS (1)
- LD 2 Ringe (1)
- LD 2 rings (1)
- LDHB (1)
- LDL (1)
- LDL-cholesterol (1)
- LEOSS (1)
- LFP (1)
- LHRH receptor (1)
- LINC00607 (1)
- LIR interaction, (1)
- LIVIN (1)
- LM11A 31 (1)
- LN229 (1)
- LNS (1)
- LOS (1)
- LPP (1)
- LQTS (1)
- LRBA (1)
- LSD1 (1)
- LSEC (1)
- LTB4 (1)
- LTBI (1)
- LTR (1)
- LU-102 (1)
- LUBAC (1)
- LUT (1)
- Label-free (1)
- Laboratory techniques and procedures (1)
- Labordiagnose (1)
- Labormedizin (1)
- Labormedizinische Spezialbefundung (1)
- Labororganisation (1)
- Laborpersonal (1)
- Lack of immunity (1)
- Lactic acidosis (1)
- Lactobacillus (1)
- Lacunar (1)
- Lafora disease (1)
- Lagerungsbedingungen (1)
- Lakunär (1)
- Laminin (1)
- LanCL2 (1)
- Land cover (1)
- Landmark (1)
- Langendorff-Herz (1)
- Langstreckige Knochendefekte (1)
- Language delay (1)
- Language disorders (1)
- Langzeitarbeitsloser (1)
- Langzeiteffekt (1)
- Langzeitergebnis (1)
- Langzeitpflege (1)
- Laparoscopic appendectomy (1)
- Laparoscopic fundoplication (1)
- Laparostomy (1)
- Laparotomy. Joel-Cohen (1)
- Laparscopic Bariatric Surgery (1)
- Large vessel occlusion (1)
- Laryngeal Tube (1)
- Laser interstitial thermal therapy (1)
- Laser navigation system (1)
- Laser-Doppler-Signal (1)
- Laser-Scan-Mikroskopie (1)
- Lasertherapie (1)
- Late Gadolinium Enhancement (LGE) (1)
- Late gadolinium enhancement (1)
- Late presentation (1)
- Latent transforming growth factor β-binding protein 4 (1)
- Lateral flow antigen testing (1)
- Lateral flow immunoassay (1)
- Lateral recess stenosis (1)
- Laterality (1)
- Laufökonomie (1)
- Le carcinome épidermoïde oral (1)
- Lead field (1)
- Leadership (1)
- Learning (1)
- Learning algorithms (1)
- Learning and memory (1)
- Learning outcomes (1)
- Lebensbewältigung (1)
- Lebensgefühl (1)
- Lebenskunst (1)
- Lebenslimitierende Erkrankungen (1)
- Lebensstiländerung (1)
- Leber (1)
- Leber congenital amaurosis (1)
- Leberkrebs (1)
- Lebermetastase (1)
- Lebertransplantation (1)
- Lecithin (1)
- Lectin affinity plasmapheresis (1)
- Lecture (1)
- Lee type, functional outcome (1)
- Lee-type (1)
- Leflunomide (1)
- Left Ventricular Mass (1)
- Left ventricular assist device (1)
- Left ventricular function (1)
- Left ventricular mass (1)
- Left ventricular non-compaction, (1)
- Leg alignment (1)
- Legal considerations (1)
- Legal medicine (1)
- Legasthenie (1)
- Legionella pneumophila (1)
- Lehre im klinischen Alltag (1)
- Lehrerausbildung (1)
- Lehrforschung (1)
- Lehrveranstaltungsevaluation (1)
- Lehrvideos (1)
- Leib (1)
- Leibesübungen (1)
- Leiblichkeit (1)
- Leibphänomenologie (1)
- Leichenschauschein (1)
- Leigh syndrome (1)
- Leipzig (1)
- Leipzig <2015> (1)
- Leipzig, Universitätskinderklinik (1)
- Leishmania infantum (1)
- Leishmaniasis (1)
- Leistung (1)
- Leistungsmessung (1)
- Leistungsorientierte Mittelvergabe (1)
- Leitbegriff (1)
- Leitlinie (1)
- Leitliniengerechte Behandlung (1)
- Leksell (1)
- Lemperle (1)
- Lenalidomide (1)
- Length of stay (1)
- Lennox-Gastaut syndrome (1)
- Lentiviral vectors (1)
- Lentiviren (1)
- Lernen (1)
- Lernerfolgsmessung (1)
- Lernziele (1)
- Les macrophages associés aux tumeurs (1)
- Lesestörung (1)
- Leseverstehen (1)
- Leseverständnis (1)
- Lesion (1)
- Leukaemia (1)
- Leukaemic Cells (1)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1)
- Leukocyte depletion filter (1)
- Leukocyte elastase (1)
- Leukodystrophy (1)
- Leukozytenfiltration (1)
- Levobupivacain (1)
- Levobupivacaine (1)
- Lhx2 (1)
- Liberalismus (1)
- Lice (1)
- Lichtalterung (1)
- Lichttherapie (1)
- Life-limiting conditions (1)
- Lifestyle (1)
- Ligand post-insertion (1)
- Ligatur (1)
- Light sheet fluorescence microscopy (1)
- Light-sheet fluorescence microscopy (1)
- Limitation of therapy (1)
- Line Notation (1)
- Lineage (1)
- Lineage tracing (1)
- Linearisierung (1)
- Linkage (1)
- Lipedema (1)
- Lipemia (1)
- Lipid Transition Temperature (1)
- Lipid metabolism (1)
- Lipid peroxidation (1)
- Lipid signaling (1)
- Lipid solution (1)
- Lipid trafficking (1)
- Lipid-based formulation (1)
- Lipidinteraktion (1)
- Lipidol (1)
- Lipidstoffwechsel (1)
- Lipiodol (1)
- Lipodystrophy (1)
- Lipopolysaccharide-binding protein (1)
- Lipoprotein(a)/Analytik (1)
- Lipoprotein(a)/analysis (1)
- Lipoproteine (1)
- Liposuction (1)
- Lippen-Kiefer-Gaumenspalte (1)
- Lipämie (1)
- Liquid filled MicroLion ion chamber array (1)
- Liquor cerebrospinalis (1)
- Liquordiagnostik (1)
- Lithium (1)
- Liver Fibrosis (1)
- Liver biopsy (1)
- Liver disease (1)
- Liver enzymes (1)
- Liver histology (1)
- Liver metastases (1)
- Liver resection (1)
- Liver transplant (1)
- Liver-Related Complications (1)
- Liver-related complications (1)
- LiverTox (1)
- LncRNA - long noncoding RNA (1)
- Loa loa (1)
- Local IgE (1)
- Local allergic rhinitis (1)
- Local control (1)
- Local field potential (1)
- Localized prostate cancer (1)
- Locally advanced (1)
- Lockdown (1)
- Loco-regional control (1)
- Locomotor circuit (1)
- Lokales IgE (1)
- Lokalisation (1)
- Lomentospora prolificans (1)
- Lomwe (1)
- Lomwe-Sprache (1)
- Long interspersed nuclear elements (LINE) (1)
- Long non-coding RNA (1)
- Long noncoding RNA (1)
- Long term output (1)
- Long term result (1)
- Long-COVID (1)
- Long-read sequencing (1)
- Long-term (1)
- Long-term continence (1)
- Long-term effect (1)
- Long-term follow up (1)
- Long-term follow-up (1)
- Long-term results (1)
- Long-term-measurements (1)
- Longchain polyunsaturated fatty acids (1)
- Longitudinal Study (1)
- Longitudinal analysis (1)
- Longitudinalstudie (1)
- Loving kindness meditation (1)
- Low Molecular Weight PTP (1)
- Low birth weight infant (1)
- Low grade glioma (1)
- Low volume prep (1)
- Low-dose X-irradiation (1)
- Low-dose ionizing radiation (1)
- Low-dose radiation therapy (1)
- Low-grade glioma (1)
- Lower back pain (1)
- Lp(a)-Lipoproteinbestimmungen (1)
- Lp(a)-lipoprotein determinations (1)
- Lpar2 (1)
- Ltbp-4 (1)
- Ltbp-4L (1)
- Ltbp-4S (1)
- Ltbp4 (1)
- Lucigenin (1)
- Luftverkehr (1)
- Lumbar spinal canal stenosis (1)
- Lumbar stenosis (1)
- Luminex (1)
- Lung (1)
- Lung Cancer (1)
- Lung Neoplasms/serum (1)
- Lung adenocarcinoma (1)
- Lung development (1)
- Lung function (1)
- Lung neoplasms (1)
- Lung ultrasound (1)
- Lungenbiopsie (1)
- Lungenerkrankungen (1)
- Lungenherde (1)
- Lungenkontusion (1)
- Lungenneoplasma/Serum (1)
- Lungentumor (1)
- Lungenversagen (1)
- Lyme Borreliosis (1)
- Lyme Disease (1)
- Lyme borreliosis (1)
- Lyme disease - Borreliosis (1)
- Lyme-Borreliose (1)
- Lymph node (1)
- Lymphadenopathy (1)
- Lymphangiectasia (1)
- Lymphangiogenesis (1)
- Lymphangioleiomyomatosis (1)
- Lymphedema (1)
- Lymphocyte subpopulations (1)
- Lymphoepithelioma (1)
- Lymphoid Neoplasia (1)
- Lymphoid tissues (1)
- Lymphoma Cells (1)
- Lymphomas (1)
- Lymphopenia Mortality (1)
- Lymphozytenantigen (1)
- Lynch-Syndrom (1)
- Lysosomal storage disease (1)
- Ländlicher Raum (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MACE (1)
- MAGGIC score (1)
- MAIT cell (1)
- MALDI MS (1)
- MAML2 (1)
- MAP Kinases (MAPKs) (1)
- MAP kinase (1)
- MAPK6 (1)
- MBC (1)
- MC-Fragen (1)
- MCH (1)
- MCP (1)
- MCP-1 (1)
- MDD (1)
- MDM2 (1)
- MDR1 (1)
- MEDIC (1)
- MEIS (1)
- MEIS homeodomain protein (1)
- MEIS2 (1)
- MEK inhibition (1)
- MEK inhibitor (1)
- MELD (1)
- MEN1 (1)
- MET (1)
- MFA (1)
- MGMT (1)
- MGMT promoter (1)
- MIC (1)
- MID task (1)
- MK-0457 (1)
- MKP1 (1)
- ML-IAP (1)
- MLC tracking (1)
- MLL fusion proteins (1)
- MLL-Baby (1)
- MLL-r acute leukemia (1)
- MLL-rearranged leukemia (1)
- MLN8237 (1)
- MLV (1)
- MLV/HIV-1 (1)
- MM-121 (1)
- MMF (1)
- MMP14 (1)
- MMP2 (1)
- MMPs (1)
- MN1 (1)
- MODY (1)
- MOLLI (1)
- MPA (1)
- MPM (1)
- MPN (1)
- MPN-U (1)
- MR-based histology (1)
- MR-guided (1)
- MR-proADM (1)
- MR-spectroscopy (1)
- MRA (1)
- MRI patterns of gliomas (1)
- MRI-negative epilepsy (1)
- MS (1)
- MSC-subsets (1)
- MSM (1)
- MT: Non-coding RNAs (1)
- MTCL (1)
- MTHFR-Mutation (1)
- MTHFR-mutation (1)
- MTL30 (1)
- MTOR inhibitor (1)
- MTRNR1 (1)
- MTRasym (1)
- MTT (1)
- MUTARS® RS Cup (1)
- MUTARS® RS Cup System (1)
- MUTARS® RS cup system (1)
- MVPA (1)
- MYCBP2 (1)
- MYCN amplification (1)
- Machine Learning (1)
- Machine learning algorithms (1)
- Macrophage (1)
- Macrophage Transdifferentiation (1)
- Macular neovascularization (1)
- Madagascar (1)
- Magnet dislocation (1)
- Magnetencephalography (1)
- Magnetfeldresonanztherapie (1)
- Magnetic resonance imaging (MRI) (1)
- Magnetic resonance spectroscopic imaging (1)
- Magnetite (1)
- Magnetoencephalographie (1)
- Magnetoencephalography (1)
- Magnetresonanztomografie (1)
- Magnetresonanztomographie (1)
- Main olfactory epithelium (1)
- Maintenance therapy (1)
- Maintenance treatment (1)
- Major Depressive Disorder (1)
- Major Histocompatibility Complex (MHC) (1)
- Major bleeding (1)
- Major infection after cardiac surgery (1)
- Makonde (1)
- Makonde-Sprache (1)
- Makrophage (1)
- Malaria prophylaxis (1)
- Malariae (1)
- Malariaprophylaxe (1)
- Male (1)
- Male Population (1)
- Malignancy (1)
- Malignant meningioma (1)
- MammaPrint (1)
- Mammalian target of rapamycin (1)
- Mammaplasty (1)
- Management (1)
- Manatee invariant (1)
- Manchester scar scale (1)
- Mandatory Vaccinations (1)
- Mandible (1)
- Mandibula (1)
- Mangel (1)
- Mania (1)
- Manuelle Lymphdrainage (1)
- Manufacturing (1)
- Maple bark disease (1)
- Maple bark strippers’ lung (1)
- Mapping (1)
- Marey, Étienne-Jules (1)
- Marginal grafts (1)
- Marginal integrity (1)
- Marine food webs (1)
- Marker genes (1)
- Market Access (1)
- Marknagelung (1)
- Markov model (1)
- Masking effect (1)
- Masquelet (1)
- Mass disaster (1)
- Massage (1)
- Massage (chinesische / japanische / ayurvedische / indische / indonesische / javanesische / balinesische Massage) (1)
- Massenkatastrophe (1)
- Massenspektrometrie (1)
- Massive Online Open Course (1)
- Master Plan 2020 (1)
- Masterplan 2020 (1)
- Mastoiditis (1)
- Matching-adjusted indirect comparison (MAIC) (1)
- Material (1)
- Materials science (1)
- Maternal Immune Activation (1)
- Maternal morbidity (1)
- Maternal separation (1)
- Mathematical Modeling (1)
- Mathematical biosciences (1)
- Mathematical functions (1)
- Mathematical methods (1)
- Mathematical model (1)
- Mathematical models (1)
- Mathematics and computing (1)
- Mathematische Biologie (1)
- Matrix metalloproteinase 1 (MMP-1) (1)
- Matrix-Metalloproteinase 1 (MMP-1) (1)
- Matrix-Rhythmus-Therapie (1)
- Maus (1)
- Maxillofacial reconstruction (1)
- Maxillofacial surgery (1)
- Maxillofacial trauma (1)
- Mcl-1 (1)
- MdM2 (1)
- Mean erythrocyte volume (1)
- Measles (1)
- Measurement equipment (1)
- Mechanical ankle instability (1)
- Mechanical ventilation (1)
- Mechanism of action (1)
- Meckel’s diverticulum (1)
- Median nerve (1)
- Mediation (1)
- Medical (1)
- Medical Education (1)
- Medical Humanities (1)
- Medical Oncology (1)
- Medical communication (1)
- Medical database (1)
- Medical errors (1)
- Medical ethics (1)
- Medical examiner (1)
- Medical history (1)
- Medical hypoxia (1)
- Medical imaging (1)
- Medical implants (1)
- Medical law (1)
- Medical management (1)
- Medical school (1)
- Medical staff (1)
- Medical student (1)
- Medical studies (1)
- Medical study (1)
- Medical traineeship (1)
- Medication Appropriatness Index (1)
- Medication changes (1)
- Medicinal chemistry (1)
- Medicinal plants (1)
- Medicine and health sciences (1)
- Medikalisierung sozialer Probleme (1)
- Medikamente (1)
- Medikamente Handlungsanweisungen (1)
- Meditation (1)
- Medizinalrhabarber (1)
- Medizinanthropologie (1)
- Medizinethik (1)
- Medizingeschichte, Lehrbuch (1)
- Medizinische Abbildung (1)
- Medizinische Chemie (1)
- Medizinische Fachangestellte (1)
- Medizinische Fehler (1)
- Medizinische Lehre (1)
- Medizinische Versorgung (1)
- Medizinisches Gutachten (1)
- Medizinisches Personal (1)
- Medizinkritik in der Literatur (1)
- Medizinrecht (1)
- Medizinstudenten 1968 (1)
- Meersseman test (1)
- Mefloquine (1)
- Mehrfachbefunde (1)
- Mehrsprachigkeit (1)
- Meis1 (1)
- Meis2 (1)
- Mekoniumaspiration (1)
- Melanocortin (1)
- Melody (1)
- Membrane Attack Complex (1)
- Membrane Protein (1)
- Membrane Trafficking (1)
- Membrane assays (1)
- Membrane staining (1)
- Membrane-Phloretin Interaction (1)
- Membranproteine (1)
- Memory quality (1)
- Memory training (1)
- Men who have sex with men (1)
- Mena/VASP (1)
- Mengele, Josef (1)
- Meningeom (1)
- Meningioma (1)
- Menschenversuche, verbrecherische (1)
- Mental disorder (1)
- Mental health disorders (1)
- Mental health problems (1)
- Mental health therapies (1)
- Mentale Vorstellung (1)
- Menthol (1)
- Mentor (1)
- Merleau-Ponty, Maurice (1)
- Mesangial cells (1)
- Mesenchym (1)
- Mesenchymal stem cell (1)
- Mesenchymal stem/stromal cells (1)
- Mesenchymal stromal cells (1)
- Mesenchymal stromal cells (MSC) (1)
- Mesh repair (1)
- Messung (1)
- Metabolic dysfunction (1)
- Metabolic labeling (1)
- Metabolic models (1)
- Metabolic vulnerabilities (1)
- Metabolism, Inborn Errors (1)
- Metabolomic profile (1)
- Metacognition (1)
- Metagenomics (1)
- Metal clip (1)
- Metalloproteases (1)
- Metalloproteinases (1)
- Metapher (1)
- Metastase (1)
- Metastasis-directed therapy (1)
- Metastatic renal cell carcinoma (1)
- Metastatic tumors (1)
- Metformin (1)
- Methacholine challenge test (1)
- Methacholinprovokation (1)
- Methadon (1)
- Methanol (1)
- Methanosarcina mazei (1)
- Methicillin resistance (1)
- Methicillin-resistenter Staphylococcus aureus (1)
- Methionine (1)
- Method validation (1)
- Methoden (1)
- Methodenvalidierung (1)
- Methodenvergleich (1)
- Methods (1)
- Methotrexate (1)
- Methylation (1)
- Methylphenidate (1)
- Metta (1)
- MiR-29 (1)
- MiSpEx Network (1)
- MiSpEx-network (1)
- Michael acceptor (1)
- Michael acceptors (1)
- Micro RNAs (1)
- Micro computed tomography (1)
- Micro-CT (1)
- MicroRNA-181a (1)
- MicroRNAs (miRNAs) (1)
- Microalgae (1)
- Microbial mutation (1)
- Microbiology and Infectious Disease (1)
- Microbiology, Virology & Host Pathogen Interaction (1)
- Microbubbles (1)
- Microdialysis (1)
- Microenvironment (1)
- Microfilaremia (1)
- Microfluidics (1)
- Microgap (1)
- Microglial cells (1)
- Micrognathia (1)
- Microparticles (1)
- Microphones (1)
- Microphysiological models (1)
- Microplastic (1)
- Microsatellite instability (1)
- Microstates (1)
- Microstructural impairment (1)
- Mid-intestinal bleeding (1)
- Midbrain/brainstem expression changes (1)
- Middle East respiratory syndrome coronavirus (1)
- Midkine (1)
- Midline laparotomy (1)
- Midwifery (1)
- Migrant health (1)
- Mikroangiopathie (1)
- Mikrobiom (1)
- Mikroneutralisationstest (1)
- Mikropartikel (1)
- Mikrostromtherapie (1)
- Mikrovesikel (1)
- Mikrowellenablation (1)
- Milch (1)
- Mild cognitive impairment (1)
- Mild hypoxia (1)
- Mind wandering (1)
- Mindestmengen (1)
- Mindfulness (1)
- Mineralocorticoids (1)
- Mineralokortikoide (1)
- Mini-monovision (1)
- Minimal Residual Disease (MRD) (1)
- Minimal core of imaging (1)
- Minimal detectable change (1)
- Minimal invasive (1)
- Minimal invasive dentistry (1)
- Minimal-invasiv (1)
- Minimale Hemmkonzentration (1)
- Minimale bakterizide Konzentration (1)
- Minimally invasive (1)
- Minimally invasive surgical procedures (1)
- Minimally invasive transforaminal interbody fusion (1)
- Minor injury (1)
- Mislocalised proteins (1)
- Missbildung (1)
- Mitochondrial Apoptosis (1)
- Mitochondrial Metabolism (1)
- Mitochondrial Permeability Transition (1)
- Mitochondrial Transport (1)
- Mitochondrial amino acid tRNA synthetases (1)
- Mitochondrial disease (1)
- Mitochondrial disorder (1)
- Mitochondrial function (1)
- Mitochondrial proteins (1)
- Mitochondrial respiration (1)
- Mitochondrial shuttles (1)
- Mitochondrien (1)
- Mitomycin C (1)
- Mitoxantrone (1)
- Mitral regurgitation (1)
- Mitral valve (1)
- Mitralklappenrekonstruktion (1)
- Mittelalter (1)
- MixCon (1)
- MixCon-LA (1)
- Mixed hearing loss (1)
- Mmp12 (1)
- Mnemonic discrimination (1)
- Mnemotechnik (1)
- Model Organism (1)
- Model organisms (1)
- Modell-Curriculum (1)
- Modelling (1)
- Modellprojekt, (1)
- Moderating factors (1)
- Moderne Medizin (1)
- Modified FDI criteria (1)
- Molar tooth sign (1)
- Molecular Biology (1)
- Molecular Chaperone (1)
- Molecular association (1)
- Molecular biophysics (1)
- Molecular diagnosis (1)
- Molecular diagnostic testing (1)
- Molecular diagnostics (1)
- Molecular docking (1)
- Molecular dynamics simulation (1)
- Molecular genetics (1)
- Molecular glue (1)
- Molecular imaging (1)
- Molecular marker (1)
- Molecular matched therapy (1)
- Molecular mechanisms of cancer (1)
- Molecular mimicry (1)
- Molecular signatures (1)
- Molecular subtype (1)
- Molecular therapy (1)
- Molecularly targeted therapy (1)
- Molekulare Therapie (1)
- Moll, Albert (1)
- Molmassenverteilung (1)
- Monacolin K (1)
- Monetary incentive delay (1)
- Mongolian spot (1)
- Monoacylglycerol lipase (1)
- Monoclonal antibodies (1)
- Monoclonal antibody (mAb) (1)
- Monocyte gene expression (1)
- Monocytes and macrophages (1)
- Monolithic crown (1)
- Monosaccharide Transport Proteins (1)
- Monotherapie (1)
- Monozyt (1)
- Monozyten (1)
- Monte Carlo method (1)
- Monte Carlo simulation (1)
- Mood (1)
- Moraceae (1)
- Morbidität (1)
- Morbus Crohn (1)
- Morbus Cushing Syndrom (1)
- Morbus Parkinson (1)
- Morphin (1)
- Morphological modeling (1)
- Morphologie (1)
- Morris Hepatoma (1)
- Mortalitätskorrektur (1)
- Mortaliät (1)
- Mosquito (1)
- Mosquito crop (1)
- Mosquito-plant interaction (1)
- Mosquitoes (1)
- Motility (1)
- Motility disorder (1)
- Motivating factor (1)
- Motivation (1)
- Motivational situation (1)
- Motivational strategies (1)
- Motivationslage (1)
- Motor cortex (1)
- Motor dysfunction (1)
- Motor neuron disease (1)
- Motor neurons (1)
- Motor skills (1)
- Motor-cognitive (1)
- Mouse model (1)
- Movement behaviour (1)
- Movement patterns (1)
- Moviprep (1)
- MptpA (1)
- Mu-opioid receptor (1)
- Mucomaix® matrix (1)
- Mucopolysaccharidoses (1)
- Mukoviszidose (1)
- Multi-Omics (1)
- Multi-center (1)
- Multi-modal feedback (1)
- Multi-motive grid (1)
- Multi-nucleated cardiomyocytes (1)
- Multi-parameter mapping (1)
- Multi-resistant pathogens (1)
- Multi-stakeholder approach (1)
- Multi-syndrome classification (1)
- Multidetector Computed Tomography (1)
- Multidisciplinary management (1)
- Multidrug-resistance (1)
- Multidrug-resistant bacteria (1)
- Multidrug-resistant organisms (1)
- Multidrug-resistant tuberculosis (1)
- Multilevel two-part modelling (1)
- Multiligament instability (1)
- Multimedia (1)
- Multimedication (1)
- Multimedikation / Polypharmazie (1)
- Multimodal Modeling (1)
- Multimodal imaging (1)
- Multimodal treatment (1)
- Multimorbid patients (1)
- Multimorbilidad (1)
- Multinomial logistic regression (1)
- Multinucleated giant cells (1)
- Multiomics (1)
- Multiparametric MRI (1)
- Multiphoton microscopy (1)
- Multiple Sclerosis (1)
- Multiple myeloma (1)
- Multiple trauma (1)
- Multiple-indication review (1)
- Multiplex immunoassay (1)
- Multiresistente Erreger (1)
- Multisensorische Integrationsleistung (1)
- Multisensory (1)
- Multiset independent component analysis (1)
- Multivariate Modellierung (1)
- Mund-Kiefer-Gesichts-Chirurgie (1)
- Mundhöhlenkarzinome (1)
- Muscarinic acetylcholine receptor (1)
- Muscle (1)
- Muscle analysis (1)
- Muscle atrophy (1)
- Muscle contractile properties (1)
- Muscle damage (1)
- Muscle differentiation (1)
- Muscle functions (1)
- Muscle pain (1)
- Muscle tissue (1)
- Muscle weakness (1)
- Muscular diseases (1)
- Musculoskeletal (1)
- Musculoskeletal abnormalities (1)
- Musculoskeletal mechanics (1)
- Musculoskeletal problems (1)
- Musculoskeletal ultrasound (1)
- Music chair concepts (1)
- Music perception (1)
- Musician (1)
- Musician-specific seating position (1)
- Musiktherapie (1)
- Muskeltonus (1)
- Muskuloskeletales System (1)
- Muskuloskelettale Erkrankungen (1)
- Muslimische Patienten (1)
- Mutant p53 (1)
- Mutation databases (1)
- Mutter (1)
- Muttermilch (1)
- Mutual information (1)
- Mycobacteria (1)
- Mycobacterium avium complex (1)
- Mycophenolat Mofetil (1)
- Mycophenolate mofetil (1)
- Mycophenolatmofetil (1)
- Mycoses (1)
- Mycosis (1)
- Myelin or myeloarchitecture (1)
- Myelodysplastic syndrome (1)
- Myelofibrosis (1)
- Myeloperoxidase (1)
- Myelopoiesis (1)
- Myeloproliferative disease (1)
- Myiasis (1)
- Mykose (1)
- Myocardial infarction (MI) (1)
- Myocardial injury (1)
- Myocardial remodeling (1)
- Myocardial revascularization (1)
- Myocardial segmentation (1)
- Myonecrosis (1)
- Myopia (1)
- Myotonic dystrophy (1)
- Mysterienspiel (1)
- Mythologie (1)
- Männerstimme (1)
- Müdigkeit (1)
- München <2011> (1)
- Mφs (1)
- N-Acetylaspartate (1)
- N-acetyl-L-cysteine (1)
- N-acetylcysteine (1)
- N-cadherin (1)
- N-cadhérine (1)
- N-glycoproteome (1)
- N-glycosylation (1)
- N-hydroxysuccinimide (1)
- N-methyl-D-aspartate receptor (1)
- N-myc (1)
- N2 (1)
- N471D strumpellin knock-in mice (1)
- N501Y (1)
- NADPH oxidase 4 (1)
- NAFL (1)
- NAPS (1)
- NAT (1)
- NCAM (1)
- NCH93 (1)
- NCOA4 (1)
- NDBI (1)
- NDM (1)
- NDNF interneurons (1)
- NDR1 (1)
- NDUFA6 (1)
- NDUFAF8 (1)
- NEAT1 (1)
- NEAT2 (1)
- NEBL (1)
- NET (1)
- NETs (1)
- NF-kB (1)
- NF-ĸB (1)
- NF-кB (1)
- NFAT (1)
- NFkB (1)
- NGS (1)
- NGS sequencing (1)
- NHE (1)
- NHEJ (1)
- NIS (1)
- NK Receptor (1)
- NK cell subset (1)
- NK cell subsets (1)
- NK receptors (1)
- NK-ZELL-BASIERTER IMMUNTHERAPIE (1)
- NK-ZELLEN (1)
- NK-Zellen (1)
- NK-cells (1)
- NKG2A blocking (1)
- NKT cell (1)
- NLPHL (1)
- NLRP3 inflammasomes (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMDAR subunit GluN2B (1)
- NMES (1)
- NMO-IgG (1)
- NMOSD (1)
- NMR Spectroscopy (1)
- NMRI (1)
- NO-GC stimulators (1)
- NOD (1)
- NOD2 (1)
- NOESY (1)
- NOS (1)
- NOS-I (1)
- NOS1AP (1)
- NOTCH (1)
- NOXA (1)
- NPC disease (1)
- NPH insulin (1)
- NPR2 (1)
- NPSR1 (1)
- NR4A3 (1)
- NRAS (1)
- NREM sleep (1)
- NS-Kindereuthanasie (1)
- NS1608 (1)
- NS3 protease inhibitor (1)
- NS3-4A protease inhibitor (1)
- NS3/4A protease inhibitors (PI) (1)
- NS3/4A-Protease (1)
- NS5A inhibitors (1)
- NS5B polymerase inhibitor (1)
- NSAIDs (1)
- NSBB (1)
- NSC350625 (1)
- NSE (1)
- NSF (1)
- NSG mice (1)
- NSTEMI (1)
- NTDs (1)
- NTM (1)
- NURF (1)
- NVBP (1)
- NXF1 (1)
- Nachteile (1)
- Nachtschattengewächs (1)
- Nachwuchsmangel (1)
- Nackenmuskulatur (1)
- Nackenschmerzen (1)
- Nahrungsmittelallergie (1)
- Nahrungsmittelhygiene (1)
- Naja (1)
- Named entity recognition (1)
- Nano-ESI MS (1)
- NanoBone (1)
- Nanocarriers (1)
- Nanocrystalline (1)
- Nanomedicine (1)
- Nanoparticles (1)
- Nanopartikel (1)
- Nanoplastic (1)
- Nanopore (1)
- Narkose (1)
- Narrativ <Sozialwissenschaften> (1)
- Nasenpolyp (1)
- Nasenschleimhaut (1)
- Nateglinide (1)
- National catalogue of competence-based learning objectives in dentistry (1)
- Native T1 (1)
- Native T1 mapping (1)
- Natriuretic peptide (1)
- Natriuretic peptides (1)
- Natural Killer (NK) Cell (1)
- Natural killer cells (1)
- Natural product (1)
- Natural products (1)
- Natural sounds (1)
- Nature (1)
- Nature contributions to people (1)
- Naturwissenschaften (1)
- Nav channel activity (1)
- Nav1.7 (1)
- Ndau (1)
- Nebennierenrinden-Adenom (1)
- Nebennierenrinden-Hyperplasie (1)
- Neck muscles (1)
- Neck pain (1)
- Necroptosis (1)
- Necrosis (1)
- Necrosis (Necrotic Death) (1)
- Necrotic area (1)
- Necrotizing fasciitis (1)
- Needs Assessment [MeSH] (1)
- Needs assessment [MeSH] (1)
- Negative appendectomy rate (1)
- Negative mental images (1)
- Negative staining (1)
- Negative-pressure wound therapy (1)
- Neglected tropical diseases (1)
- Negligence (1)
- Nek1 (1)
- Nekrose (1)
- Neoadjuvant radiochemotherapy (1)
- Neoadjuvant systemic therapy (1)
- Neoadjuvant therapy (1)
- Neoadjuvant treatment (1)
- Neocortex (1)
- Neonatal (1)
- Neonatal abstinence syndrome (1)
- Neonatal brain damage (1)
- Neonatal intensive care unit (1)
- Neonatal morbidity (1)
- Neonatal outcome (1)
- Neonatal surgery outcome (1)
- Neonatal urea cycle disorders (1)
- Neonatales Entzugssyndrom (1)
- Neonatologie (1)
- Nephelometrie und Turbidimetrie (1)
- Nephelometry and Turbidimetry (1)
- Nephrogenese (1)
- Nephrons (1)
- Nephropathie (1)
- Nerven <Begriff> (1)
- Nervenkrankheit (1)
- Nerves (1)
- Nervous system diseases (1)
- Nesplora Aquarium (1)
- Network analysis (1)
- Network model (1)
- Network models (1)
- Network motifs (1)
- Netzhaut (1)
- Netzhaut ; Nervenzelle ; Inhibition (1)
- Neuer Mensch (1)
- Neugeborene (1)
- Neugeborenen-Hörscreeningverfahren ; DPOAE- und AABR-Messungen ; Gerätevergleich ABaer und Ero-Scan (1)
- Neural Network (1)
- Neural coding (1)
- Neural correlates of consciousness (1)
- Neural encoding models (1)
- Neural function (1)
- Neural goal function (1)
- Neural map (1)
- Neural signature (1)
- Neurasthenie (1)
- Neuro-ophthalmology (1)
- NeuroSAFE (1)
- Neurobiology of disease and regeneration (1)
- Neuroblastom, SAMHD1, Chemoresistenz (1)
- Neuroblastoma (1)
- Neuroblasts (1)
- Neurochemistry (1)
- Neurocognition (1)
- Neurodegenerative diseases (1)
- Neurodegenerative syndromes (1)
- Neurodevelopment (1)
- Neurodevelopmental Psychiatric Disorders (1)
- Neurodevelopmental disorder (1)
- Neurodevelopmental disorders (1)
- Neuroendocrine cancer (1)
- Neuroendocrine tumor (1)
- Neuroepithelial (1)
- Neuroepithelial tumor (1)
- Neurofeedback (1)
- Neurofilament light chain (1)
- Neurofilament light chains (1)
- Neurofilament-Leichtketten (1)
- Neurofuzzy medical systems (1)
- Neurogenese (1)
- Neurogenesis (1)
- Neurohypophyse (1)
- Neuroligins (1)
- Neurologe (1)
- Neurologiegeschichte (1)
- Neurologisches Institut <Frankfurt am Main> (1)
- Neuromodulatorisches Netzwerk (1)
- Neuromodulatory network (1)
- Neuromuscular exercise (1)
- Neuromyelitis optica (1)
- Neuron-Specific Enolase/serum (1)
- Neuron-spezifische Enolase/Serum (1)
- Neuronal homeostasis (1)
- Neuronal migration (1)
- Neuronal network models (1)
- Neuronal networks (1)
- Neuronal nitric oxide synthase (1)
- Neuronal oscillations (1)
- Neuronales Netzwerk (1)
- Neuronavigation (1)
- Neuronspecific Enolase (1)
- Neuronspezifische-Enolase (1)
- Neurooncology (1)
- Neuropathie (1)
- Neuropathologie (1)
- Neuropilin (1)
- Neuroprotection (1)
- Neuroprotektion (1)
- Neuropsychiatric disorders (1)
- Neuropsychiatrie (1)
- Neuropsychological testing (1)
- Neuropsychologie (1)
- Neuropsychology (1)
- Neuroscience, neural computation & artificial intelligence (1)
- Neurosciences (1)
- Neurostimulation (1)
- Neurotransmission (1)
- Neurotrophe Faktoren (1)
- Neurovascular damage (1)
- Neurovascular lesion (1)
- Neurowissenschaften (1)
- Neutrophils (1)
- Nevus of Ito (1)
- Nevus of Ota (1)
- New Developments (1)
- New E3-ligase ligands (1)
- Newbornhearingscreening (1)
- Next generation sequencing (1)
- NfL (1)
- Nfe2l2 (1)
- Niche (1)
- Niche differentiation (1)
- Nicht-Ereignis (1)
- Nicht-allergische Rhinitis (1)
- Nichtversicherung (1)
- Nicolaides-Baraitser syndrome (1)
- Nicotine (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nicotinic acetylcholine receptors (1)
- Niere (1)
- Nierendosimetrie (1)
- Nikotin (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nikotinerge Acetylcholinrezeptoren (1)
- Nimotuzumab (1)
- Nitric Oxide Synthase (1)
- Nkx2-5 (1)
- Nociception (1)
- Nociceptors (1)
- Nodular lymphocyte predominant Hodgkin lymphoma (1)
- Non-Hodgkin Lymphoma (1)
- Non-Hodgkin lymphoma (1)
- Non-Hodgkin-Lymphom (1)
- Non-RCT (1)
- Non-abusive head trauma (NAHT) (1)
- Non-alcoholic fatty liver disease (1)
- Non-allergic-rhinitis (1)
- Non-aneurysmal (1)
- Non-apoptotic functions (1)
- Non-clear cell renal cell cancer (1)
- Non-coding RNAs (1)
- Non-diffractive EDOF-IOL (1)
- Non-expert MRI (1)
- Non-falciparum (1)
- Non-invasive brain stimulation (1)
- Non-neuronal cholinergic system (1)
- Non-nucleoside polymerase inhibitors (NNI) (1)
- Non-operative (1)
- Non-perimesencephalic (1)
- Non-responder (1)
- Non-small-cell lung cancer (1)
- Non-steroidal anti-inflammatory drugs (1)
- Non-trauma (1)
- Non-tuberculous mycobacteria (1)
- Non-urothelial (1)
- Non-vitamin K antagonist oral anticoagulants (1)
- Nonaerosolizing treatment (1)
- Noncoding RNA (1)
- Nonfermenter (1)
- Noninferiority (1)
- Nonlinear analysis (1)
- Nonoperative management (1)
- Nonpenetrating (1)
- Nonsteroidal anti-inflammatory drugs (1)
- Nontuberculous mycobacteria (1)
- Nonunion (1)
- Non–small-cell lung cancer (1)
- Noradrenergic (1)
- Nordhrine-Westfalia (1)
- Nordic questionnaire (1)
- Nordrhein-Westfalen (1)
- Norepinephrine (1)
- Normalkollektiv (1)
- Normative modeling (1)
- Notch (1)
- Notch signaling (1)
- Notfallausweis (1)
- Notfallversorgung (1)
- Novel treatment target (1)
- Nox inhibition (1)
- NoxA1 (1)
- Nozizeption (1)
- Npr2 (1)
- Nrf-2 (1)
- Nucleolar protein 14 (1)
- Nucleolus (1)
- Nucleophosmin-1 (1)
- Nucleus pulposus cells (1)
- Nucleus reuniens (1)
- Nukleinsäure-Amplifikationstechnik (NAT) (1)
- Nukleinsäureamplifikationstest (NAT) (1)
- Nuklid (1)
- Null responder (1)
- Number of platelets (1)
- Nurses (1)
- Nursing (1)
- Nutrition risk stratification (1)
- Nyanja (1)
- Nyanja-Sprache (1)
- Nymphs (1)
- Nyungwe (1)
- O-GlcNAcylation (1)
- OA (1)
- ODEs (1)
- OECD performance standards (1)
- OGR1 (1)
- OGTT (1)
- OHIP-G14 (1)
- OHRQoL (1)
- ONC201 (1)
- OP capacity (1)
- OP-Kapazität (1)
- OPRM1 methylation (1)
- OPS (1)
- OR time (1)
- ORES (1)
- ORIS (1)
- ORL (1)
- ORP (1)
- OSA (1)
- OSF-2 KI-S2 (1)
- OTSC Proctology (1)
- OXA-23 (1)
- OXA-484 (1)
- OXA-58 (1)
- OXPHOS (1)
- Oberarmbruch (1)
- Oberflächenantigen-Mutante (1)
- Object perception (1)
- Object-scene associations (1)
- Objectives (1)
- Objektivität (1)
- Observational studies (1)
- Obsessive-compulsive disorder (1)
- Obstetric care (1)
- Obstetrics (1)
- Obstruktive Bronchitis (1)
- Occlusion (1)
- Occupational Accidents (1)
- Occupational exposure (1)
- Occupational medicine (1)
- Occupational reintegration management (1)
- Occupationally acquired infection (1)
- Ocular findings (1)
- Ocular tuberculosis (1)
- Odorant receptor (1)
- Oesophageal cancer (1)
- Oesophagogastric cancer oxaliplatin (1)
- Off-pump surgery (1)
- Office work (1)
- Ohnr (1)
- Ohrakupunktur (1)
- Ohrenheilkunde (1)
- Ohrenkrankheit (1)
- Okinawa (1)
- Okinawa diet (1)
- Okklusivverband (1)
- Okulist (1)
- Old-old (1)
- Older adult (1)
- Older patient (1)
- Older patients (1)
- Oldest-old (1)
- Olfactory diagnostics (1)
- Olfactory groove meningioma (1)
- Oligodendrogliom (1)
- Oligodendroglioma (1)
- Oligometastatic (1)
- Olive <Anatomie> (1)
- Omega lipids (1)
- Omega-3-Fettsäuren (1)
- Omicron variant BA.1 (1)
- Omics (1)
- Omphalocele (1)
- Omphalozele (1)
- Oncogenes (1)
- Oncologic surgery (1)
- Oncolytic adenovirus (1)
- Oncolytic virus (1)
- Oncoprotein activation (1)
- Oncosomes (1)
- Oncotargets (1)
- One health (1)
- One-leg stand (1)
- Onkogene (1)
- Onkomodulation (1)
- Online Survey (1)
- Online education (1)
- Online-Lehre (1)
- Online-Lernen (1)
- Online-Magazin (1)
- Online-Magazine (1)
- Online-Publikation (1)
- Online-Umfrage (1)
- Opacity (1)
- Open Access (1)
- Open abdomen (1)
- Open pulmonary tuberculosis (1)
- Open source concept (1)
- Open-access data resource (1)
- Operationsvorbereitung (1)
- Ophthalmologie (1)
- Ophthalmoplegia (1)
- Opiatrezeptor (1)
- Opinion (1)
- Opioid system (1)
- Opium (1)
- Oposterior urethral valve (1)
- Oppositional defant disorder (1)
- Oppositional defiant disorder (1)
- Optic nerve atrophy (1)
- Optical coherence tomography angiography (1)
- Optical lenses (1)
- Optical phenomena (1)
- Optimal wiring (1)
- Optisches Signal (1)
- Oral Health Impact Profile (OHIP) (1)
- Oral and maxillofacial surgery (1)
- Oral and maxillofacial trauma (1)
- Oral cancer (1)
- Oral food challenge (1)
- Oral immunotherapy (OIT) (1)
- Oral implantology (1)
- Oral therapy (1)
- Orale Antikoagulanzien (1)
- Orbital fracture (1)
- Orexin (1)
- Organ allocation (1)
- Organ failure (1)
- Organ injury (1)
- Organ motion (1)
- Organ rinse (1)
- Organ shortage (1)
- Organ support (1)
- Organ-confined (1)
- Organs at Risk (1)
- Orientation preference (1)
- Oroantral communication (1)
- Orphan disease (1)
- Orphan nuclear receptor (1)
- Orthodontic tooth movement (1)
- Orthodontist (1)
- Orthopaedics (1)
- Ortspezifische Mutagenese (1)
- Oryctolagus cuniculus (1)
- Oscillating saws (1)
- Osimertinib (1)
- Osmosensing (1)
- Osmostress (1)
- OspE (1)
- Ossifying fibroma (1)
- Osteoarthritis (1)
- Osteocalcin (1)
- Osteoinduction (1)
- Osteonecrosis (1)
- Osteoporose (1)
- Osteoporosis diagnosis (1)
- Osteoporotic fractures (1)
- Oswestry Disability Score (1)
- Otorhinolaryngological (1)
- Otorhinolaryngology (1)
- Outbreak (1)
- Outcome assessment [MeSH] (1)
- Outlier detection (1)
- Ovale (1)
- Ovarian cancer treatment (1)
- Ovarian carcinoma (1)
- Ovarielle Reserve (1)
- Ovartoxizität (1)
- Ovary (1)
- Over-the-scope clip (1)
- Overall survival (1)
- Overweight (1)
- Overwintering (1)
- Oxa1/YidC/Alb3 Membrane Insertases (1)
- Oxaliplatin (1)
- Oxanthrone Glucosyls (1)
- Oxford Nanopore Technologies (1)
- Oxidoreductases (1)
- Oxygen (1)
- Oxygen consumption (1)
- Oxygen extraction fraction (1)
- Oxygen uptake (1)
- Oxygen-derived free radicals (1)
- P-TEFb (1)
- P-gp (1)
- P1NP (1)
- P23/PTGES3 (1)
- P2X3 (1)
- PACS (1)
- PAD-test (1)
- PAD4 (1)
- PAI-1 (1)
- PAM (1)
- PAPR (1)
- PAR (1)
- PARK4 (1)
- PARK6 (1)
- PARK7 (1)
- PATZ1 (1)
- PAX3/FOXO1 (1)
- PBBM (1)
- PBM (1)
- PBMC (peripheral blood mononuclear cells) (1)
- PBPK simulation (1)
- PBSC (1)
- PBX (1)
- PBX1 (1)
- PC12 neuronal differentiation (1)
- PC12APPsw (1)
- PC20 (1)
- PCA (1)
- PCP (1)
- PCSK9 protein (1)
- PCV (1)
- PD-1 inhibitor (1)
- PD20 (1)
- PDCD4 (1)
- PDD - Assessment - Screening (1)
- PDE (1)
- PDE inhibition (1)
- PDE‐5‐inhibitor (1)
- PDI (1)
- PDK1 (1)
- PDPK1 (1)
- PEA-15 (1)
- PEGylated PLGA (PLGA-PEG) (1)
- PEI (1)
- PELICAN (1)
- PEM-technology (1)
- PF-06273340 (1)
- PFL (1)
- PFOA (1)
- PFOS (1)
- PGC-1 alpha (1)
- PGC-1α (1)
- PHGDH (1)
- PHR1 (1)
- PI3K inhibitor (1)
- PI3K/mTor inhibition (1)
- PID prevalence (1)
- PIF pocket (1)
- PIK3CA (1)
- PIM kinases (1)
- PING (1)
- PKA (1)
- PKCδ (1)
- PKCε (1)
- PKD (1)
- PKD/IC (1)
- PLA (1)
- PLAGL1 (1)
- PLGA nanoparticles (1)
- PLK1 (1)
- PLK1 inhibitors (1)
- PLSC (1)
- PLX4032 (1)
- PLX4720 (1)
- PM (1)
- PMA (1)
- PMF (1)
- PMI (1)
- PMMA (1)
- PMNs (1)
- POCT (1)
- POLG (1)
- POR (1)
- PPAR (1)
- PPAR gamma activator (1)
- PPAR-γ (1)
- PPTC7 (1)
- PRG-1 (1)
- PRG5 (1)
- PRIMUM-Studie (1)
- PRLTS3 (1)
- PROM (1)
- PROMISE (1)
- PRRT (1)
- PRRT2 (1)
- PRoMPT (1)
- PSA screening (1)
- PSA-Screening (1)
- PTCH (1)
- PTCH-1 (1)
- PTDM (1)
- PTEN inducible kinase 1 (1)
- PTEN p53 Survivin (1)
- PTK2B (1)
- PTM (1)
- PTP-1B (1)
- PUMA (1)
- PV (1)
- PV loop (1)
- PWI (1)
- PXA (1)
- PYGL (1)
- PacBio SMRT sequencing (1)
- Paediatric Investigation Plan (1)
- Paediatric cancer (1)
- Paediatric oncology (1)
- Paediatric research (1)
- Paediatric trauma patients (1)
- Paediatrics (1)
- Pain behavior (1)
- Pain intensity (1)
- Pain patients (1)
- Pain prevalence (1)
- Pain scale MWA (1)
- Palacos reaction (1)
- Palliative Care [MeSH] (1)
- Palmitoylethanolamid (1)
- Pancreas transplantation (1)
- Pancreatic islet (1)
- Pancreatic surgery (1)
- Pancreatitis (1)
- Pancreatoduodenectomy (1)
- Pandemic Ethics (1)
- Pandemics (1)
- Panel testing (1)
- Panic disorder (1)
- Papillon-Lefèvre syndrome (1)
- Par-4 (1)
- Paracelsus, Asteroid (1)
- Paracetamol (1)
- Parainfluenza (1)
- Parameter estimation (1)
- Paramyxoviridae (1)
- Paraneoplastic syndrome (1)
- Parapneumonic pleural effusion (1)
- Parasympathetic (1)
- Parent support (1)
- Parkinson-Krankheit (1)
- Parkinsonerkrankung (1)
- Parkinsons disease (1)
- Parodontitis (1)
- Parodontitistherapie (1)
- Partial agonist (1)
- Partial least square correlation (1)
- Particle image velocimetry (1)
- Particle load reduction (1)
- Particle number size distribution (1)
- Particle size distribution (1)
- Particle toxicity (1)
- Particles (1)
- Particulates (1)
- Passivrauch (1)
- Patch-Clamp-Methode (1)
- Patch-clamp (1)
- Patellarerkrankungen (1)
- Patellofemoral Joint (1)
- Path dependency (1)
- Pathogen (1)
- Pathogen reduction (1)
- Pathogenicity (1)
- Pathogens (1)
- Pathologic changes (1)
- Pathological complete response (1)
- Pathologists (1)
- Pathology Section (1)
- Pathophysiologie (1)
- Pathophysiology (1)
- Patient Blood Management (PBM) (1)
- Patient Outcome Assessment (1)
- Patient Outcome Assessment [MeSH] (1)
- Patient Reported Outcome Measures [MeSH] (1)
- Patient and public Involvement (1)
- Patient care (1)
- Patient care planning (1)
- Patient education (1)
- Patient information (1)
- Patient information materials (1)
- Patient isolation (1)
- Patient knowledge (1)
- Patient outcome assessment (1)
- Patient participation (1)
- Patient perspective (1)
- Patient portals (1)
- Patient preferences (1)
- Patient reported outcomes (1)
- Patient satisfaction (1)
- Patient*inneninformation (1)
- Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (1)
- Patient-centered care (1)
- Patient-reported outcomes (1)
- Patienten (1)
- Patientenaufklärung (1)
- Patientenportale (1)
- Patientensicherheit (1)
- Patientenstudie (1)
- Pattern classification (1)
- Pattern recognition receptors (1)
- Pattern separation (1)
- Pause (1)
- Pdgfrβ (1)
- Peanut allergy (1)
- Pedagogue (1)
- Pediatric burn injury (1)
- Pediatric fracture (1)
- Pediatric neuroimaging (1)
- Pediatric oncology (1)
- Pediatric sarcoma (1)
- Pediatric stem cell transplantation (1)
- Pediatric surgery (1)
- Pediatrics [MeSH] (1)
- PedsQL (1)
- Peer Teaching (1)
- Peer review (1)
- Peer teaching (1)
- Peer-feedback (1)
- Peer-teaching (1)
- Peg3 (1)
- Pegylated liposomal doxorubicin (1)
- Pelargonium sidoides questionable hepatotoxicity (1)
- Pelvic (1)
- Penetration (1)
- Penetrationsverstärker (1)
- Penile Neoplasms (1)
- Pentose Pathway (1)
- Peptid-Aptamer (1)
- Peptides (1)
- Peptides and proteins (1)
- Per1−/−-mice (1)
- Perceived stigma (1)
- Perceived vulnerability to disease (1)
- Percutaneous (1)
- Percutaneous endoscopic gastrostomy (1)
- Percutaneous pinning (1)
- Percutaneous ultrasound (1)
- Performance (1)
- Performance Metrics (1)
- Performing Artists (1)
- Peri-implant disease (1)
- Pericardial effusion (1)
- Pericarditis (1)
- Perifolliculitis capitis abscedens et suffodiens (1)
- Perilymph (1)
- Perimesencephalic (1)
- Perinatalzentren (1)
- Periodic (1)
- Periodontal disease (1)
- Periodontal diseases (1)
- Periodontal trauma (1)
- Periodontitis grades B and C (1)
- Peripheral arterial occlusive disease (1)
- Peripheral blood smears (1)
- Peripheral vascular disease (1)
- Periphere arterie (1)
- Periprocedural anticoagulation (1)
- Peritoneal macrophages (1)
- Peritumoural oedema (1)
- Perizyten (1)
- Peri‑implantitis (1)
- Perkutane transluminale Angioplastie (1)
- Permeability (1)
- Peroxidase (1)
- Perrault syndrome (1)
- Persistence SARS-CoV-2 antibodies (1)
- Persistent depressive disorder (1)
- Persistent organic pollutants (1)
- Persistierender Ductus arteriosus (1)
- Personal medicine (1)
- Personal protective equipment (1)
- Personal stigma (1)
- Personalbelastung (1)
- Personalised medicine (1)
- Personality (1)
- Personality disorder (1)
- Personality inventory (1)
- Personalized Medicine (1)
- Personalmangel (1)
- Personnel shortage (1)
- Perspective forum (1)
- Perspektivforum (1)
- Persönlichkeitsfaktor (1)
- Pertussis (1)
- Pessar (1)
- Peutz–Jeghers syndrome (1)
- Peyronie's disease (1)
- Pfannenstiel (1)
- Pflegeeinrichtungen (1)
- Pgrmc1 (1)
- Phage Display (1)
- Phakic (1)
- Phalangeal fractures (1)
- Phantom study (1)
- Phantoms (imaging) (1)
- Pharm-fMRI (1)
- Pharma Management (1)
- Pharmaceutical (1)
- Pharmaco-nutrition (1)
- Pharmacodynamic (1)
- Pharmacodynamics (1)
- Pharmacokinetic Interactions (1)
- Pharmacokinetics (1)
- Pharmacological treatment (1)
- Pharmacometrics (1)
- Pharmacophore (1)
- Pharmacotherapy (1)
- Pharmacovigilance (1)
- Pharmacy setting (1)
- Pharmaka (1)
- Pharmakoepidemiologie (1)
- Pharmazeutische Chemie (1)
- Pharmazeutische Technologie (1)
- Pharmazie (1)
- Pharyngeal reflex (1)
- Phase 2 (1)
- Phase 3 (1)
- Phase 3 trial (1)
- Phase I clinical trial (1)
- Phase I trials (1)
- Phase II trial (1)
- Phase rotors (1)
- Phase-IV research (1)
- Phase-Proteine (1)
- Phase-reset (1)
- Phenazinderivate (1)
- Phenomenology (1)
- Phenotypic plasticity (1)
- Phenprocoumon (1)
- Phenylketonuria (PKU) (1)
- Philadelphia Chromosome (1)
- Philadelphia Chromosome-positive leukemia (1)
- Philadelphia chromosome-positive acute leukemia (1)
- Philemon and Baucis (1)
- Philemon und Baucis (1)
- Philosophie (1)
- Phlyctenule (1)
- Phosphatase (1)
- Phospho-soda (1)
- Phospho-tau (1)
- Phosphodiesterases (1)
- Phospholipasen A2 (1)
- Phospholipids (1)
- Phosphoproteome (1)
- Phosphopyruvate Hydratase/serum (1)
- Phosphopyruvathydratase/Serum (1)
- Phosphorylierung (1)
- Photodynamische Therapie (1)
- Photodynamische Therapie (PDT) (1)
- Photographie (1)
- Photosensibilisator (1)
- Phraseological games (1)
- Phraseologie (1)
- Phraseologische Spiele (1)
- Phylogeny (1)
- Physical activity intervention (1)
- Physical and chemical properties (1)
- Physical and mental health (1)
- Physical comorbidities (1)
- Physical fitness (1)
- Physical self-perception (1)
- Physical therapist (1)
- Physician report (1)
- Physician-assisted suicide (1)
- Physics of Living Systems (1)
- Physiologie (1)
- Physiotherapie (1)
- Physiotherapy (1)
- Phytochemicals (1)
- Phytopharmakon (1)
- Phänomenologische Soziologie (1)
- Pierre Robin sequence (1)
- Pill Count (1)
- PillCamColon2 (1)
- Pilocytic astrocytoma (1)
- Pilze (1)
- Pilzsinusitis (1)
- Pim-1 (1)
- Pindar, Pythische Ode III (1)
- Pink esthetic score (1)
- Pink1 (1)
- Pinwheel (1)
- Pittsburgh Sleep Quality Index (1)
- Placental growth factor (1)
- Placental organoids (1)
- Plague (1)
- Planning target volume (1)
- Plantagearbeiter (1)
- Plantation workers (1)
- Plants (1)
- Plaque <Medizin> (1)
- Plasma fibronectin (1)
- Plasma proteins (1)
- Plasma transfusion (1)
- Plasma usage (1)
- Plasmacytoid dendritic cell (1)
- Plasmapools (1)
- Plasmaprotein analyzer (1)
- Plasmaproteinanalysensysteme (1)
- Plasmaproteinbestimmung im Harn (1)
- Plasmaproteine (1)
- Plasmapräparate (1)
- Plasminogen (1)
- Plastic endoprosthesis (1)
- Plastic pollution (1)
- Plastics (1)
- Plastikstent (1)
- Platelet (1)
- Platelet dysfunction (1)
- Platelet lysate (1)
- Platelet releasate (1)
- Platzierung (1)
- Plausibilität (1)
- Play (1)
- Play sports (1)
- Pleasure (1)
- Plectin (1)
- Plethysmographie (1)
- Pleural empyema (1)
- Plk1 (1)
- Plättchen-Leukozyten-Aggregate (1)
- Plättchenaktivierung (1)
- Pneumococcal conjugate vaccine (1)
- Pneumothorax (1)
- Poe, Der wahre Sachverhalt im Falle Valdemar (1)
- Point of care (1)
- Point-of-Care Testing (POCT) (1)
- Point-of-care wound diagnostics (1)
- Polarisierung (1)
- Polarity index (1)
- Policy implementation (1)
- Poliomyelitis (1)
- Polioviren (1)
- Polizei (1)
- Polo-like kinase 3 (1)
- Poly-Pore (1)
- Polyenfettsäuren (1)
- Polygenic risk score (1)
- Polyhexanide (1)
- Polymerase Chain Reaction (1)
- Polymerase Chain Reaction (PCR) (1)
- Polymerase Kettenreaktion (PCR) (1)
- Polymerase-Kettenreaktion (1)
- Polymerasekettenreaktion (1)
- Polymorphismen (1)
- Polyphenole (1)
- Polyposis (1)
- Polyposis syndrome (1)
- Polyps (1)
- Polysomnography (1)
- Polyunsaturated fatty acid mediators (1)
- Polyunsaturated fatty acids (1)
- Polyzystisches Ovarsyndrom (1)
- Política de Saúde (1)
- Ponatinib (1)
- Pooling (1)
- Poor solubility (1)
- Population dynamics (1)
- Population-based screening (1)
- Porin regulation (1)
- Porphyromonas gingivalis (1)
- Portal (1)
- Porträt (1)
- Portugal (1)
- Portuguese population (1)
- Posaconazole serum level (1)
- Position paper (1)
- Positive mental images (1)
- Positron emission tomography (1)
- Positron-emission tomography (1)
- Post mortem examination (1)
- Post mortem interval (1)
- Post surgery pain (1)
- Post treatment (1)
- Post-cesarean (1)
- Post-mortem genetic screening (1)
- Post-offence drinking (1)
- Post-thaw recovery (1)
- Post-transplant (1)
- Posterior Cerebral (1)
- Postmortem (1)
- Postmortem interval (1)
- Postoperative Complications (1)
- Postoperative anatomy (1)
- Postoperative infections (1)
- Postoperative nutritional management (1)
- Posttranslational modification (1)
- Postural sway (1)
- Posture (1)
- Postvention (1)
- Potassium channel Kir2.1 (1)
- Potassium iodide (1)
- Powered air-purifying respirator (1)
- Pp (1)
- Ppk (1)
- PrEP (1)
- Practical training (1)
- Practice (1)
- Practice-based Research Network (1)
- Practice-based research network (1)
- Praeklampsie (1)
- Praktische Fertigkeiten (1)
- Praktische Lehre (1)
- Praktisches Jahr (1)
- Pre-economic effects (1)
- Pre-emptive immunotherapy (1)
- Pre-operative radiotherapy (1)
- Pre-treatment drug resistance mutations (1)
- PreS1 deletion (1)
- Precision (1)
- Precision medicine (1)
- Precision oncology (1)
- Preclinical (1)
- Preclinical drug development (1)
- Precompetitive development (1)
- Prediction of locoregional recurrence (1)
- Predictive Modeling (1)
- Predictive medicine (1)
- Predictive model (1)
- Predictive modeling (1)
- Predictive processing (1)
- Predictors (1)
- Prefrontal cortex (1)
- Pregnant smokers (1)
- Premotor cortex (1)
- Prenatal ultrasonographic detection rate (1)
- Preoperative diagnostics (1)
- Preoperative radiochemotherapy (1)
- Prepontine (1)
- Presbyopia (1)
- Preseniline (1)
- Pressure distribution (1)
- Pressure measuring plate (1)
- Pressure pain (1)
- Presynaptic vesicles (1)
- Preußen (1)
- Prevention of Muscle Lesion (1)
- Preventive behavior (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Primary Care Health Centre (1)
- Primary Care Research Network (1)
- Primary breast lymphoma (1)
- Primary health care [MeSH] (1)
- Primary molars (1)
- Primary prophylaxis (1)
- Primary sclerosing cholangitis (1)
- Principal component analysis (1)
- Priorisierung in der Medizin (1)
- Pro.M.D. (1)
- Probenidentifikation (1)
- Procaine (1)
- Procedural Ethics (1)
- Procedural skills (1)
- Process Capability (1)
- Process Performance (1)
- Process Validation (1)
- Process evaluation (1)
- Processing (1)
- Produkte zur Desinfektion (1)
- Professional dancers (1)
- Professionalism (1)
- Professioneller Fußball (1)
- Professions (1)
- Profi-Tänzer*innen (1)
- Proficiency testing (1)
- Profilometry (1)
- Progestatifs synthétiques (1)
- Progesteron (1)
- Progesteron-Rezeptor (1)
- Progesterone (1)
- Prognostic biomarker (1)
- Prognostic models (1)
- Prognostische Marker (1)
- Programming languages (1)
- Proinflammatory cytokines (1)
- Projekte Seltene Erkrankungen (1)
- Prolonged grief disorder (1)
- Promoters (1)
- Propensity score matching (1)
- Propensity-Score Matching Analyse (1)
- Proposal (1)
- Propriozeption (1)
- Prospective randomized Analysis (1)
- Prostaglandin (1)
- Prostaglandin D2 (1)
- Prostaglandin E2 (1)
- Prostaglandine (1)
- Prostata-specific antigen (1)
- Prostataarterienembolisation (1)
- Prostatakrankheit (1)
- Prostatakrebs (1)
- Prostate Cancer (1)
- Prostate cancer cell lines (1)
- Prostate-specific membrane antigen (1)
- Prostatic specific antigen (1)
- Prosthetic rehabilitation (1)
- Protease activity (1)
- Proteasome inhibitor (1)
- Proteasomes (1)
- Protective factors (1)
- Protein (1)
- Protein Domains (1)
- Protein Expression (1)
- Protein Folding (1)
- Protein Kinase Inhibitors (1)
- Protein Motifs (1)
- Protein Targeting (1)
- Protein Translocation (1)
- Protein aggregates (1)
- Protein biosynthesis (1)
- Protein domains (1)
- Protein folding (1)
- Protein interactions (1)
- Protein kinase (1)
- Protein purify derivative (1)
- Protein tyrosine modification (1)
- Protein-Kinasen (1)
- Protein-Lipid Interaction (1)
- Protein-Protein Interactions (1)
- Protein-Tyrosin-Kinasen (1)
- Protein-translocation (1)
- Proteinbestimmung (1)
- Proteintransduktion (1)
- Proteintyrosinphosphatasen (1)
- Proteinuria (1)
- Proteinurie (1)
- Protektion (1)
- Proteostasis (1)
- Protestantism (1)
- Protestbewegung (1)
- Prothese (1)
- Prothrombin complex concentrate (1)
- Prothrombinmutation (1)
- Protocol (1)
- Protokoll-Compliance (1)
- Proton density (1)
- Prototypes (1)
- Proximal (1)
- Proximal humeral fracture (1)
- Proximale Ballonokklusion (1)
- Prä-B-Zellen (1)
- Präanalytik (1)
- Prädiktor (1)
- Präpulsinhibition (1)
- Präsenzdiagnostik (1)
- Präventivmedizin (1)
- Präzision und Richtigkeit (1)
- Prüfung (1)
- Prüfungen (1)
- Prüfungsfragen (1)
- Pseudo HE-images (1)
- Pseudophakia (1)
- Pseudoprogression (1)
- Psoriasis vulgaris (1)
- Psoriatic arthritis (1)
- Psyche (1)
- Psychiatric traits (1)
- Psychiatrisches Gutachten (1)
- Psychiatry (1)
- Psycho-oncology (1)
- Psychodynamic psychotherapy (1)
- Psychologische Beeinträchtigung (1)
- Psychometric evaluation (1)
- Psychometric tests (1)
- Psychometrics (1)
- Psychopathie (1)
- Psychopathologie (1)
- Psychophysics (1)
- Psychosocial (1)
- Psychosocial impact (1)
- Psychosomatik (1)
- Pteridine (1)
- PtkA (1)
- Public Health Ethics (1)
- Public and occupational health (1)
- Publication (1)
- Publication output (1)
- Pulmonale Hypertonie (1)
- Pulmonary artery pressure (1)
- Pulmonary disease, chronic obstructive (1)
- Pulmonary edema (1)
- Pulmonary failure (1)
- Pulmonary hypoplasia (1)
- Puls (1)
- Pulse contour analysis (1)
- Pulse pressure variation (1)
- Pulsed SILAC (1)
- Pulswellengeschwindigkeit (1)
- Pumpkin seeds (1)
- Punktion (1)
- Pupillometry (1)
- Purdue Pegboard (1)
- Purkinje cells (1)
- Pustulosis (1)
- Puumala virus (1)
- Pyogenic (1)
- Pyogenic spondylodiscitis (1)
- Pyramidenbahn (1)
- Pyrazole (1)
- Pyruvate (1)
- Pythagoras Institut Philosophischer Studien der Unsterblichkeit des Menschen (1)
- Pythagorean Institute of Philosophical Studies for the Immortality of Men (1)
- Python (1)
- Pädagoge/in (1)
Institute
- Medizin (7405)
- Pharmazie (297)
- Biowissenschaften (270)
- Präsidium (254)
- Biochemie, Chemie und Pharmazie (232)
- Biochemie und Chemie (215)
- Frankfurt Institute for Advanced Studies (FIAS) (155)
- Georg-Speyer-Haus (130)
- Sportwissenschaften (130)
- Psychologie (94)
Graph4Med: a web application and a graph database for visualizing and analyzing medical databases
(2022)
Background
Medical databases normally contain large amounts of data in a variety of forms. Although they grant significant insights into diagnosis and treatment, implementing data exploration into current medical databases is challenging since these are often based on a relational schema and cannot be used to easily extract information for cohort analysis and visualization. As a consequence, valuable information regarding cohort distribution or patient similarity may be missed. With the rapid advancement of biomedical technologies, new forms of data from methods such as Next Generation Sequencing (NGS) or chromosome microarray (array CGH) are constantly being generated; hence it can be expected that the amount and complexity of medical data will rise and bring relational database systems to a limit.
Description
We present Graph4Med, a web application that relies on a graph database obtained by transforming a relational database. Graph4Med provides a straightforward visualization and analysis of a selected patient cohort. Our use case is a database of pediatric Acute Lymphoblastic Leukemia (ALL). Along routine patients’ health records it also contains results of latest technologies such as NGS data. We developed a suitable graph data schema to convert the relational data into a graph data structure and store it in Neo4j. We used NeoDash to build a dashboard for querying and displaying patients’ cohort analysis. This way our tool (1) quickly displays the overview of patients’ cohort information such as distributions of gender, age, mutations (fusions), diagnosis; (2) provides mutation (fusion) based similarity search and display in a maneuverable graph; (3) generates an interactive graph of any selected patient and facilitates the identification of interesting patterns among patients.
Conclusion
We demonstrate the feasibility and advantages of a graph database for storing and querying medical databases. Our dashboard allows a fast and interactive analysis and visualization of complex medical data. It is especially useful for patients similarity search based on mutations (fusions), of which vast amounts of data have been generated by NGS in recent years. It can discover relationships and patterns in patients cohorts that are normally hard to grasp. Expanding Graph4Med to more medical databases will bring novel insights into diagnostic and research.
Angesichts der Bedrohung durch den Klimawandel sind Maßnahmen zur Reduktion von Treibhausgasemissionen dringend notwendig. Obwohl auf den Gesundheitssektor 5 bis 10 % der nationalen Treibhausgasemissionen entfallen, spielt das Thema Nachhaltigkeit in deutschen Kliniken bisher nur eine untergeordnete Rolle. Studien der letzten Jahre haben gezeigt, dass die Nutzung von Mehrwegartikeln gegenüber der Nutzung von Einwegartikeln in der Anästhesiologie einen Vorteil in Bezug auf die CO2-Emissionen bieten kann. Gleichzeitig stehen Kliniken vor der Herausforderung, kosteneffizient zu handeln. In der vorliegenden Promotionsarbeit werden deshalb die CO2-Emissionen sowie die Kosten von Einweg-Beatmungsschlauchsystemen, Einweg-Beatmungsmasken und Einweg-Laryngoskopspateln im Zentral-OP des Universitätsklinikums Frankfurt pro Nutzung ermittelt und diese mit den Kosten sowie den CO2-Emissionen von entsprechenden Mehrweg-Alternativen pro Nutzung verglichen. Daraus soll eine Handlungsempfehlung für die künftige Verwendung von Mehrwegmaterial oder Einwegmaterial abgeleitet und ein Beitrag zur Nachhaltigkeit in der Anästhesiologie geleistet werden.
Methodisch wurde eine deskriptive Untersuchung umgesetzt. Die Daten wurden anhand von Informationen, die von den Produktherstellern, der Host Energie GmbH, der Abteilung Einkauf und den Mitarbeiterinnen und Mitarbeitern der Materialaufbereitung des Universitätsklinikums Frankfurt zur Verfügung gestellt wurden sowie durch eigene Erhebung gesammelt. Die Kosten pro Nutzung wurden anhand der realen Bezugspreise aus dem Jahr 2022 für die Einwegmaterialien bzw. der Angebote der Anbieter für die Mehrwegprodukte errechnet. Die Kosten der Entsorgung wurden gewichtsbezogen addiert. Für die Mehrwegartikel wurden zudem die Kosten der Aufbereitung berücksichtigt. Für die Kalkulationen der CO2-Emissionen wurden die Konversionsfaktoren des DEFRA aus Großbritannien verwendet, die bei bekanntem Produktgewicht eine näherungsweise Bestimmung der Treibhausgasemissionen der Materialproduktion, der Entsorgung und der Aufbereitung erlauben. Patientendaten wurden nicht verwendet, so dass weder ein Ethikvotum noch ein Datenschutzvotum erforderlich waren.
Die Ergebnisse zeigen, dass alle untersuchten Mehrwegartikel pro Nutzung günstiger sind als die äquivalenten Einwegartikel, wobei der Preisunterschied bei den Laryngoskopspateln am größten ist. Diese kosten als Einwegartikel 2,66 € pro Nutzung, die Mehrweg-Alternative 0,12 € pro Nutzung. Gleichzeitig sind die Treibhausgasemissionen pro Nutzung für alle untersuchten Mehrwegartikel niedriger als für die entsprechenden Einwegartikel. Der Unterschied ist hier ebenfalls bei den Laryngoskopspateln am größten. Ein Einweg-Laryngoskopspatel der Größe 4 generiert pro Nutzung 0,228 kg CO2-Äquivalent, wohingegen die Mehrweg-Alternative nur 0,093 kg CO2-Äquivalent verursacht.
Im Fazit ergibt sich dadurch, dass die Verwendung von Mehrweg-Beatmungsschlauchsystemen, Mehrweg-Beatmungsmasken und Mehrweg-Laryngoskopspateln für das Universitätsklinikum Frankfurt einen sowohl ökonomischen als auch ökologischen Vorteil gegenüber der Verwendung der Einwegartikel bietet. Die Umstellung zu Mehrwegartikeln in der Anästhesiologie hat somit nicht nur das Potenzial Kosten einzusparen, sondern auch den CO2-Fußabdruck im Gesundheitssektor zu senken.
A broad range of neuropsychiatric disorders are associated with alterations in macroscale brain circuitry and connectivity. Identifying consistent brain patterns underlying these disorders by means of structural and functional MRI has proven challenging, partly due to the vast number of tests required to examine the entire brain, which can lead to an increase in missed findings. In this study, we propose polyconnectomic score (PCS) as a metric designed to quantify the presence of disease-related brain connectivity signatures in connectomes. PCS summarizes evidence of brain patterns related to a phenotype across the entire landscape of brain connectivity into a subject-level score. We evaluated PCS across four brain disorders (autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder, and Alzheimer’s disease) and 14 studies encompassing ∼35,000 individuals. Our findings consistently show that patients exhibit significantly higher PCS compared to controls, with effect sizes that go beyond other single MRI metrics ([min, max]: Cohen’s d = [0.30, 0.87], AUC = [0.58, 0.73]). We further demonstrate that PCS serves as a valuable tool for stratifying individuals, for example within the psychosis continuum, distinguishing patients with schizophrenia from their first-degree relatives (d = 0.42, p = 4 x 10−3, FDR-corrected), and first-degree relatives from healthy controls (d = 0.34, p = 0.034, FDR-corrected). We also show that PCS is useful to uncover associations between brain connectivity patterns related to neuropsychiatric disorders and mental health, psychosocial factors, and body measurements.
Purpose: To evaluate intermediate and long-term visual outcomes and safety of a phakic intraocular posterior chamber lens with a central hole (ICL V4c) for myopic eyes.
Methods: Retrospective, consecutive case study of patients that uneventfully received a ICL V4c for myopia correction, with a 5-year postoperative follow-up. Department of Ophthalmology, Goethe University Frankfurt, Germany.
Results: From 241 eyes that underwent ICL implantation, we included 45 eyes with a mean age at surgery of 33 years ± 6 (18–48 years), with a 5 years follow-up. CDVA improved from 0.05logMAR ± 0.15 CDVA preoperatively to − 0.00 ± 0,07 at 5 years and did not change significantly from 3 to 5 years’ time (p = 0.266). The mean spherical equivalent (SE) improved from -10.13D ± 3.39 to − 0.45D ± 0.69. The change in endothelial cell count showed a mean decrease of 1.9% per year throughout the follow-up. Safety and efficacy index were 1.16 and 0.78, respectively. Cataract formation was seen in 2 of 241 eyes (0.8%), but in none of the 45 eyes that finished the 5-year follow-up.
Conclusions: Our data show a good intermediate and long-term stability, efficiency, and safety of ICL V4c phakic lenses in myopic eyes comparable to other known literature.
Die Appendizitis stellt mit einer Inzidenz von 115 pro 100000 Einwohnern in Deutschland eine der häufigsten Ursachen für ein akutes Abdomen dar. Bakterielle Infektionen sind ein wesentlicher Faktor für die postoperative Morbidität nach Appendektomie.
Ziel dieser prospektiven Studie war es, das Keimspektrum und insbesondere die Prävalenz resistenter Keime bei der akuten Appendizitis zu bestimmen und die Auswirkungen resistenter Keime auf das Auftreten infektiöser Komplikationen zu analysieren. Alle erwachsenen Patient*innen mit akuter Appendizitis, die zwischen April 2022 und Juli 2023 am Universitätsklinikum Frankfurt operativ behandelt wurden, wurden prospektiv eingeschlossen. Das Keimspektrum der Appendix und die Häufigkeit von MRE in Rektalabstrichen wurden analysiert. Die klinischen Daten wurden extrahiert, um die Korrelation des Keimspektrums mit dem Auftreten von postoperativen Komplikationen, Dauer und Art der Antibiotikatherapie und dem postoperativen Verlauf zu evaluieren. 30 Tage nach der Operation wurde ein Follow-up durchgeführt. Insgesamt wurden 105 Patient*innen in die Studie eingeschlossen.
In den Appendixabstrichen gelang ein Erregernachweis bei 67,6 % aller Fälle. Hierbei betrug die Prävalenz von Keimen mit Antibiotikaresistenz 43,8 %, Multipler-Antibiotikaresistenz (MAR) 27,6 % und bei 5,7 % der Fälle gelang ein MRE-Nachweis nach CDC im Appendixabstrich. Beim MRE-Screening konnten im Rektalabstrich bei 11,4 % der Patient*innen ein MRE nachgewiesen werden. In vier Fällen zeigte sich eine Übereinstimmung zwischen rektalen und appendikulären Abstrich, somit betrug die Sensitivität des MRE-Screenings für einen Nachweis multiresistenter Keime in der Appendix lediglich 33,3 % bei einer Spezifität von 86,7 %. In einer univariaten Analyse konnte das Vorliegen eines Diabetes mellitus als Risikofaktor für das Auftreten von Keimen mit Cefuroxim- Resistenz, Multipler-Antibiotikaresistenz (MAR) und MRE identifiziert werden.
Insgesamt erhielten 47,6 % aller Patient*innen postoperativ eine Antibiotikatherapie, von denen erfolgte bei 46 % eine Umstellung der empirischen Antibiose auf eine antibiogramm-gerechte Therapie nach Erhalt des mikrobiologischen Befundes. Insbesondere Patient*innen mit komplizierter Appendizitis erhielten postoperativ eine Antibiotikatherapie, wobei 28 % eine Antibiotikaeskalation benötigten.
Patient*innen, deren Appendixabstriche eine Resistenz gegen maximal ein Antibiotikum aufwiesen, wurden als nicht multiple Resistenz (Nicht-MAR) definiert und mit Patient*innen verglichen, deren Keime mit multipler Antibiotikaresistenz (MAR) waren. Die MAR-Gruppe zeigte im Vergleich zur Nicht-MAR-Gruppe eine höhere Inzidenz postoperativer Komplikationen, insbesondere eine erhöhte Inzidenz von Clavien-Dindo Grad 3 Komplikationen sowie von tiefen postoperativen Wundinfektionen (CDC Grad A3). Weiterhin benötigten Patient*innen der MAR-Gruppe häufiger eine postoperative Antibiotikatherapie und es erfolgte häufiger eine Eskalation der antibiotischen Therapie. Dies ging auch mit einem signifikant verlängerten Krankenhausaufenthalt einher.
Zusammenfassend kann festgestellt werden, dass eine bakterielle Infektion mit Multipler Antibiotikaresistenz bei der akuten Appendizitis häufig auftritt und die Morbidität nach Appendektomie beeinflusst. Die mikrobiologische Untersuchung mittels Appendixabstrich bei operativ behandelten Fällen von akuter komplizierter Appendizitis, die eine postoperative Antibiotikatherapie erfordern, könnte somit eine gezielte und kürzere Antibiotikatherapie ermöglichen. Dies könnte dazu beitragen, längere Krankenhausaufenthalte zu vermeiden, den unnötigen Einsatz unwirksamer Antibiotika zu reduzieren und die Kosten im Gesundheitswesen zu senken.
Polygene Risikoscores (PRS) integrieren zahlreiche Einzelnukleotid-Polymorphismen (SNP) von meist geringer Effektstärke, um Auskunft über das Erkrankungsrisiko bestimmter Krankheiten zu geben. In dieser Arbeit wurde der PRS zur genetisch generalisierten Epilepsie (GGE) von Leu et al. aus dem Jahr 2019 untersucht, um festzustellen, ob über das Erkrankungsrisiko hinaus noch Korrelationen mit weiteren phänotypischen Eigenschaften von Patienten bestehen. Der Nachweis solcher Zusammenhänge würde eine Prädiktionsfähigkeit des GGE-PRS demonstrieren, die perspektivisch ein Potential für dessen klinische Anwendbarkeit, beispielsweise im Sinne der personalisierten Medizin, aufzeigen könnte.
Die Identifizierung neuer Korrelationen sollte durch Vergleich der Phänotypen von zwei Gruppen von GGE-Patienten mit extrem hohen, beziehungsweise extrem niedrigen PRS-Werten erfolgen. Hierfür wurden von 2256 Patienten aus der Datenbank von Epi25, einem internationalen Forschungskollaborativ zur Erforschung der Relevanz genetischer Faktoren bei der Entwicklung von Epilepsie, die Patienten mit den höchsten (n=59) und den niedrigsten (n=49) GGE-PRS-Werten ausgewählt. Für diese 108 Patienten wurden retrospektive klinische Daten von den jeweiligen Behandlungszentren akquiriert. Hierzu wurde den Studienleitern der Zentren ein Questionnaire mit Fragen zu zahlreichen phänotypischen Parametern der Patienten übermittelt. Die Rücklaufrate war mit 54% gut.
Die so eingeholten Patientendaten wurden anschließend mittels Exaktem Test nach Fisher und Wilcoxon-Rangsummentest statistisch analysiert, um Unterschiede zwischen den Phänotypen beider Gruppen nachzuweisen. Im Falle der Pharmakoresistenz zeichneten sich hierbei zunächst signifikante Unterschiede ab, die ein selteneres Auftreten dieser Eigenschaft für Patienten mit hohen GGE-PRS-Werten implizierten. Diese Ergebnisse waren jedoch nach einer Bonferroni-Korrektur und bei Validierung in einer größeren Kohorte (n=825) nicht mehr signifikant. Für die anderen untersuchten Parameter waren ebenfalls keine signifikanten Unterschiede nachweisbar.
Das Ergebnis, dass für keinen der untersuchten Parameter signifikante Differenzen bestanden, obwohl zwei Kohorten mit extrem gegensätzlichen PRS-Werten untersucht wurden, spricht gegen eine Verwendung des aktuell verfügbaren GGE-PRS als prädiktiver Biomarker über das Erkrankungsrisiko hinaus und somit gegen dessen klinische Anwendbarkeit. Jedoch können die nicht-signifikanten Korrelationen im Falle der Pharmakoresistenz als Hinweis verstanden werden, dass im Bereich der Pharmakotherapie Zusammenhänge zwischen Score und Phänotyp bestehen könnten, die weiterer Untersuchungen in zukünftigen Studien bedürfen. Bei Verwendung eines verbesserten GGE-PRS mit zusätzlichen risikoassoziierten SNP und verfeinerter Wichtung der Effektstärken sowie größerer Kohorten könnten in diesem Bereich möglicherweise auch signifikante Zusammenhänge nachweisbar werden.
Background: Prostate cancer is a major health concern in aging men. Paralleling an aging society, prostate cancer prevalence increases emphasizing the need for efcient diagnostic algorithms.
Methods: Retrospectively, 106 prostate tissue samples from 48 patients (mean age,
66 ± 6.6 years) were included in the study. Patients sufered from prostate cancer (n = 38) or benign prostatic hyperplasia (n = 10) and were treated with radical prostatectomy or Holmium laser enucleation of the prostate, respectively. We constructed tissue microarrays (TMAs) comprising representative malignant (n = 38) and benign (n = 68) tissue cores. TMAs were processed to histological slides, stained, digitized and assessed for the applicability of machine learning strategies and open–source tools in diagnosis of prostate cancer. We applied the software QuPath to extract features for shape, stain intensity, and texture of TMA cores for three stainings, H&E, ERG, and PIN-4. Three machine learning algorithms, neural network (NN), support vector machines (SVM), and random forest (RF), were trained and cross-validated with 100 Monte Carlo random splits into 70% training set and 30% test set. We determined AUC values for single color channels, with and without optimization of hyperparameters by exhaustive grid search. We applied recursive feature elimination to feature sets of multiple color transforms.
Results: Mean AUC was above 0.80. PIN-4 stainings yielded higher AUC than H&E and
ERG. For PIN-4 with the color transform saturation, NN, RF, and SVM revealed AUC of 0.93 ± 0.04, 0.91 ± 0.06, and 0.92 ± 0.05, respectively. Optimization of hyperparameters improved the AUC only slightly by 0.01. For H&E, feature selection resulted in no increase of AUC but to an increase of 0.02–0.06 for ERG and PIN-4.
Conclusions: Automated pipelines may be able to discriminate with high accuracy between malignant and benign tissue. We found PIN-4 staining best suited for classifcation. Further bioinformatic analysis of larger data sets would be crucial to evaluate the reliability of automated classifcation methods for clinical practice and to evaluate potential discrimination of aggressiveness of cancer to pave the way to automatic precision medicine.
This prospective study sought to evaluate potential savings of radiation dose to medical staff using real-time dosimetry coupled with visual radiation dose feedback during angiographic interventions. For this purpose, we analyzed a total of 214 angiographic examinations that consisted of chemoembolizations and several other types of therapeutic interventions. The Unfors RaySafe i2 dosimeter was worn by the interventionalist at chest height over the lead protection. A total of 110 interventions were performed with real-time radiation dosimetry allowing the interventionalist to react upon higher x-ray exposure and 104 examinations served as the comparative group without real-time radiation monitoring. By using the real-time display during interventions, the overall mean operator radiation dose decreased from 3.67 (IQR, 0.95–23.01) to 2.36 μSv (IQR, 0.52–12.66) (−36%; p = 0.032) at simultaneously reduced operator exposure time by 4.5 min (p = 0.071). Dividing interventions into chemoembolizations and other types of therapeutic interventions, radiation dose decreased from 1.31 (IQR, 0.46-3.62) to 0.95 μSv (IQR, 0.53-3.11) and from 24.39 (IQR, 12.14-63.0) to 10.37 μSv (IQR, 0.85-36.84), respectively, using live-screen dosimetry (p ≤ 0.005). Radiation dose reductions were also observed for the participating assistants, indicating that they could also benefit from real-time visual feedback dosimetry during interventions (−30%; p = 0.039). Integration of real-time dosimetry into clinical processes might be useful in reducing occupational radiation exposure time during angiographic interventions. The real-time visual feedback raised the awareness of interventionalists and their assistants to the potential danger of prolonged radiation exposure leading to the adoption of radiation-sparing practices. Therefore, it might create a safer environment for the medical staff by keeping the applied radiation exposure as low as possible.
The combination of histological and biomolecular analyses provides deep understanding of different biological processes and is of high interest for basic and applied research. However, the available analytical methods are still limited, especially when considering bone samples. This study compared different fixation media to identify a sufficient analytical method for the combination of histological, immuno-histological and biomolecular analyses of the same fixed, processed and paraffin embedded bone sample. Bone core biopsies of rats’ femurs were fixed in different media (RNAlater + formaldehyde (R + FFPE), methacarn (MFPE) or formaldehyde (FFPE)) for 1 week prior to decalcification by EDTA and further histological processing and paraffin embedding. Snap freezing (unfixed frozen tissue, UFT) and incubation in RNAlater were used as additional controls. After gaining the paraffin sections for histological and immunohistological analysis, the samples were deparaffined and RNA was isolated by a modified TRIZOL protocol. Subsequently, gene expression was evaluated using RT-qPCR. Comparable histo-morphological and immuno-histological results were evident in all paraffin embedded samples of MFPE, FFPE and R + FFPE. The isolated RNA in the group of MFPE showed a high concentration and high purity, which was comparable to the UFT and RNAlater groups. However, in the groups of FFPE and R + FFPE, the RNA quality and quantity were statistically significantly lower when compared to MFPE, UFT and RNAlater. RT-qPCR results showed a comparable outcome in the group of MFPE and UFT, whereas the groups of FFPE and R + FFPE did not result in a correctly amplified gene product. Sample fixation by means of methacarn is of high interest for clinical samples to allow a combination of histological, immunohistological and biomolecular analysis. The implementation of such evaluation method in clinical research may allow a deeper understanding of the processes of bone formation and regeneration.
Hepatic cells are sensitive to internal and external signals. Ethanol is one of the oldest and most widely used drugs in the world. The focus on the mechanistic engine of the alcohol-induced injury has been in the liver, which is responsible for the pathways of alcohol metabolism. Ethanol undergoes a phase I type of reaction, mainly catalyzed by the cytoplasmic enzyme, alcohol dehydrogenase (ADH), and by the microsomal ethanol-oxidizing system (MEOS). Reactive oxygen species (ROS) generated by cytochrome (CYP) 2E1 activity and MEOS contribute to ethanol-induced toxicity. We aimed to: (1) Describe the cellular, pathophysiological and clinical effects of alcohol misuse on the liver; (2) Select the biomarkers and analytical methods utilized by the clinical laboratory to assess alcohol exposure; (3) Provide therapeutic ideas to prevent/reduce alcohol-induced liver injury; (4) Provide up-to-date knowledge regarding the Corona virus and its affect on the liver; (5) Link rare diseases with alcohol consumption. The current review contributes to risk identification of patients with alcoholic, as well as non-alcoholic, liver disease and metabolic syndrome. Additional prevalence of ethnic, genetic, and viral vulnerabilities are presented.
Mitochondrial RNA granules (MRGs) are membraneless, highly specialized compartments that play an essential role in the post-transcriptional regulation of mitochondrial gene expression. This regulation is crucial for maintaining energy production, controlling metabolic functions and ensuring homeostasis in cells. Dysregulation of mitochondrial genes has been linked to various human diseases, including neurodegenerative and metabolic disorders as well as certain types of cancer.
MRGs are composed of different RNA species, including mitochondrial precursor RNA (pre-RNA), mature tRNAs, rRNAs and mRNAs complexed with multiple proteins involved in RNA processing and mitoribosome assembly. However, despite the significance of MRGs, their protein composition, structural organization, stability and dynamics during stress conditions remain elusive. In the study reported here, I adopted a three-step approach to address the aforementioned fundamental issues.
First and foremost, I identified the protein composition of MRGs and unveiled their architectural complexity. To characterize the MRG proteome, I applied the cutting-edge TurboID-based proximity labeling approach combined with quantitative mass spectrometry. Proximity labeling was conducted on 20 distinct MRG-associated human proteins, resulting in the identification of more than 1,700 protein-protein interactions. This expansive dataset enabled me to create a comprehensive network, providing valuable insights into both the (sub)architecture as well as the core structure of MRGs in-depth.
Secondly, I investigated the spatio-temporal dynamics of MRGs under various mitochondrial stress conditions. To monitor the morphological alterations and compositional changes of MRGs, I utilized time-resolved confocal fluorescence microscopy and proteomics, respectively. In this analysis, I applied IMT1, the first specific inhibitor that selectively targets mitochondrial transcription. Using this methodology, I pinpointed precise conditions that triggered MRGs’ disassembly during stress, followed by their reassembly when nascent RNA production was restored. The results of this examination elucidate that MRGs are highly dynamic and stress adaptive structures, capable of rapid dissolution and reassembly, a process closely connected to mitochondrial transcription.
Thirdly, I aimed to explore the impact of RNA turnover on MRGs’ integrity during stress, employing confocal fluorescence microscopy and quantitative real-time PCR. I observed that depletion of MRG proteins associated with RNA degradation counteracts MRGs’ disassembly under stress conditions, a phenomenon attributed to the accumulation of double-stranded RNA (dsRNA). These results emphasize the critical role of pre-RNA turnover in maintaining MRG integrity and reveal that MRGs can be stabilized by dsRNA.
Taken together, the comprehensive investigation reported in this thesis has substantially broadened and deepened our understanding of MRGs’ complexity. By identifying their molecular structure and dynamics, I have gained significant insights into the fundamental characteristics and biological functions of MRGs in cellular processes. This knowledge contributes to the identification of disease-related pathways linked to mitochondrial gene expression and may inspire future studies to develop novel therapeutic approaches.
Aim
To compare overall mortality (OM), cancer-specific mortality (CSM), and other cause mortality (OCM) rates between radical prostatectomy (RP) versus radiotherapy (RT) in clinical node-positive (cN1) prostate cancer (PCa).
Materials and Methods
Within Surveillance, Epidemiology, End Results (SEER) (2004–2016), we identified 4685 cN1 PCa patients, of whom 3589 (76.6%) versus 1096 (24.4%) were treated with RP versus RT. After 1:1 propensity score matching (PSM), Kaplan–Meier plots and Cox regression models tested the effect of RP versus RT on OM, while cumulative incidence plots and competing-risks regression (CRR) models addressed CSM and OCM between RP and RT patients. All analyses were repeated after the inverse probability of treatment weighting (IPTW). For CSM and OCM analyses, the propensity score was used as a covariate in the regression model.
Results
Overall, RT patients were older, harbored higher prostate-specific antigen values, higher clinical T and higher Gleason grade groups. PSM resulted in two equally sized groups of 894 RP versus 894 RT patients. After PSM, 5-year OM, CSM, and OCM rates were, respectively, 15.4% versus 25%, 9.3% versus 17%, and 6.1% versus 8% for RP versus RT (all p < 0.001) and yielded respective multivariate hazard ratios (HRs) of 0.63 (0.52–0.78, p < 0.001), 0.66 (0.52–0.86, p < 0.001), 0.71 (0.5–1.0, p = 0.05), all favoring RP. After IPTW, Cox regression models yielded HR of 0.55 (95% confidence interval [CI] = 0.46–0.66) for OM, and CRR yielded HRs of 0.49 (0.34–0.70) and 0.54 (0.36–0.79) for, respectively, CSM and OCM, all favoring RP (all p < 0.001).
Conclusions
RP may hold a CSM advantage over RT in cN1 PCa patients.
The intensity and the features of sensory stimuli are encoded in the activity of neurons in the cortex. In the visual and piriform cortices, the stimulus intensity rescales the activity of the population without changing its selectivity for the stimulus features. The cortical representation of the stimulus is therefore intensity invariant. This emergence of network-invariant representations appears robust to local changes in synaptic strength induced by synaptic plasticity, even though (i) synaptic plasticity can potentiate or depress connections between neurons in a feature-dependent manner, and (ii) in networks with balanced excitation and inhibition, synaptic plasticity determines the nonlinear network behavior. In this study we investigate the consistency of invariant representations with a variety of synaptic states in balanced networks. By using mean-field models and spiking network simulations, we show how the synaptic state controls the emergence of intensity-invariant or intensity-dependent selectivity. In particular, we demonstrate that an effective power-law synaptic transformation at the population level is necessary for invariance. In a range of firing rates, purely depressing short-term synapses fulfills this condition, and in this case, the network is contrast-invariant. Instead, facilitating short-term plasticity generally narrows the network selectivity. We found that facilitating and depressing short-term plasticity can be combined to approximate a power-law that leads to contrast invariance. These results explain how the physiology of individual synapses is linked to the emergence of invariant representations of sensory stimuli at the network level.
A plethora of modified nucleotides extends the chemical and conformational space for natural occurring RNAs. tRNAs constitute the class of RNAs with the highest modification rate. The extensive modification modulates their overall stability, the fidelity and efficiency of translation. However, the impact of nucleotide modifications on the local structural dynamics is not well characterized. Here we show that the incorporation of the modified nucleotides in tRNAfMet from Escherichia coli leads to an increase in the local conformational dynamics, ultimately resulting in the stabilization of the overall tertiary structure. Through analysis of the local dynamics by NMR spectroscopic methods we find that, although the overall thermal stability of the tRNA is higher for the modified molecule, the conformational fluctuations on the local level are increased in comparison to an unmodified tRNA. In consequence, the melting of individual base pairs in the unmodified tRNA is determined by high entropic penalties compared to the modified. Further, we find that the modifications lead to a stabilization of long-range interactions harmonizing the stability of the tRNA’s secondary and tertiary structure. Our results demonstrate that the increase in chemical space through introduction of modifications enables the population of otherwise inaccessible conformational substates.
Research in social insects has shown that hydrocarbons on their cuticle are species-specific. This has also been proven for Diptera and is a promising tool for identifying important fly taxa in Forensic Entomology. Sometimes the empty puparia, in which the metamorphosis to the adult fly has taken place, can be the most useful entomological evidence at the crime scene. However, so far, they are used with little profit in criminal investigations due to the difficulties of reliably discriminate among different species. We analysed the CHC chemical profiles of empty puparia from seven forensically important blow flies Calliphora vicina, Chrysomya albiceps, Lucilia caesar, Lucilia sericata, Lucilia silvarum, Protophormia terraenovae, Phormia regina and the flesh fly Sarcophaga caerulescens. The aim was to use their profiles for identification but also investigate geographical differences by comparing profiles of the same species (here: C. vicina and L. sericata) from different regions. The cuticular hydrocarbons were extracted with hexane and analysed using gas chromatography-mass spectrometry. Our results reveal distinguishing differences within the cuticular hydrocarbon profiles allowing for identification of all analysed species. There were also differences shown in the profiles of C. vicina from Germany, Spain, Norway and England, indicating that geographical locations can be determined from this chemical analysis. Differences in L. sericata, sampled from England and two locations in Germany, were less pronounced, but there was even some indication that it may be possible to distinguish populations within Germany that are about 70 km apart from one another.
With the introduction of the virtual allocation crossmatch in the Eurotransplant (ET) region in 2023, the determination of unacceptable antigen mismatches (UAM) in kidney transplant recipients is of utmost importance for histocompatibility laboratories and transplant centers. Therefore, a joined working group of members from the German Society for Immunogenetics (Deutsche Gesellschaft für Immungenetik, DGI) and the German Transplantation Society (Deutsche Transplantationsgesellschaft, DTG) revised and updated the previous recommendations from 2015 in light of recently published evidence. Like in the previous version, a wide range of topics is covered from technical issues to clinical risk factors. This review summarizes the evidence about the prognostic value of contemporary methods for HLA antibody detection and identification, as well as the impact of UAM on waiting time, on which these recommendations are based. As no clear criteria could be determined to differentiate potentially harmful from harmless HLA antibodies, the general recommendation is to assign all HLA against which plausible antibodies are found as UAM. There is, however, a need for individualized solutions for highly immunized patients. These revised recommendations provide a list of aspects that need to be considered when assigning UAM to enable a fair and comprehensible procedure and to harmonize risk stratification prior to kidney transplantation between transplant centers.
Inflammation is a crucial host defense mechanism activated in response to injury or infection. Its primary goal is to eliminate the source of the disturbance, repair the damaged tissue, and restore homeostasis. Inflammatory processes can be recognized through increased blood flow, higher vascular permeability, and the recruitment of leukocytes and plasma proteins to the tissue. A pathogen-induced inflammation triggers various pro- and anti-inflammatory processes. Local tissue cells and Toll-like receptors call upon innate immune cells like neutrophils, dendritic cells (DCs), and monocytes to respond to the intruder. They move across the endothelium and respond to local signals by releasing mediators or cytotoxic compounds, phagocytosing, or polarizing. To study local pathogen-induced inflammation, a zymosan-induced inflammation model was used in the hind paws of mice, which caused a Toll-like receptor 2 mediated inflammation. Multi-Epitope-Ligand-Cartography (MELC) was used for multiple sequential immunohistochemistry with 40 different antibodies on the same tissue. Bioinformatic analysis and graphical representation revealed a specific inflammatory architecture consisting of three major areas based on macrophage polarization and their cellular neighborhoods: a core region containing the pathogen, a pro-inflammatory region containing M1-like macrophages, and a region containing anti-inflammatory cells. This discovery highlights the coexistence of pro- and antiinflammatory processes during an ongoing inflammation and challenges the concept of a gradual temporal transition from pro- to anti-inflammation. Flow cytometry of the whole paw was performed to support and refine the MELC results. Eosinophils were used as a specific immune cell population to investigate their role in the inflammatory structure. They were found to be present in all three inflammatory regions, adapting their cytokine profile according to their localization. Depleting eosinophils reduced Interleukin 4 (IL-4)- levels, increased edema formation, and mechanical and thermal hypersensitivities during inflammation resolution. In the absence of eosinophils, pro- and anti-inflammatory region could not be determined in the inflammatory architecture, neutrophil numbers increased, and efferocytosis and M2-macrophage polarization were reduced. IL-4 administration restored these regions, normalized neutrophil numbers, efferocytosis, M2-macrophage polarization, and resolution of zymosan-induced hypersensitivity. The results show that eosinophils expressing IL-4 support the resolution of inflammation by enabling the development of an anti-inflammatory framework that encloses pro-inflammatory regions.
In Deutschland leidet ca. jeder zehnte Mensch über 40 Jahren an einer chronischen Einschränkung seiner Nierenfunktion. Nicht wenige davon sind im Laufe der Erkrankung auf eine Nierenersatztherapie angewiesen. Die Ursachen für eine Nierenschädigung sind vielfältig. Als neuartiger und vielversprechender Therapieansatz werden aktuell Mesenchymale Stamm-/Stromazellen (MSC) als Therapeutikum für diverse Nierenerkrankungen getestet. Erste Ergebnisse klinischer Phase-I-Studien zeigen, dass MSC sicher als Immunsuppressivum nach Nierentransplantation angewendet werden können. Auch für weitere Erkrankungen der Niere sind erste klinische Studien am Laufen. MSC gelten als regenerativ, immunsupprimierend und antientzündlich. Dennoch gibt es noch einige Limitationen. Nach der Transplantation der Zellen ist das Wachstum der Zellen oft eingeschränkt und es kommt zur vermehrten Apoptose. Auch wird immer wieder ein paradoxes und entzündungsförderndes Verhalten der MSC am Wirkort beobachtet. Ein wichtiger Lösungsansatz ist eine in vitro Vorbehandlung der MSC zur Modulierung der zellulären Eigenschaften. In dieser Arbeit wurden drei Substanzen und Arzneimittel auf ihre Fähigkeit untersucht, die entzündungshemmenden Eigenschaften der MSC zu verbessern und die entzündungsfördernden zu unterdrücken. Der Fokus lag hierbei auf dem Arzneimittel Niclosamid und den beiden bisher noch nicht zugelassenen Substanzen Berberin und Gedunin, die alle in vitro und in vivo bereits erste vielversprechende antientzündliche Wirkungen bewiesen haben. Für diese Arbeit wurden MSC aus Fettgewebe isoliert (ASC) und mit LPS oder einem Cytokin-Mix (Mischung aus TNF-α, IFN-γ und IL-1β) sowie den drei Substanzen stimuliert. Untersucht wurden im Anschluss die mRNA-Expressionen der gängigsten proinflammatorischen (TNF-α, IL-6, TLR-4, ICAM-1, HLA-DR) und antiinflammatorischen Marker (IDO, IL-10), sowie mittels ELISA die Protein-Freisetzung von IL-6 und IL-8. Die vielversprechendsten Ergebnisse ließen sich durch Berberin hervorrufen. Hier zeigte sich eine deutliche Senkung der IL-8-Konzentration im ELISA. Die Anwendung des Gedunin hatte keine signifikante Wirkung auf die ASC. Niclosamid hingegen scheint widererwarten sogar entzündungsfördernd zu wirken, in dem es die IL-6-, ICAM-1-mRNA-Expression steigerte und die IDO-mRNA-Expression absenkte. Unter den drei getesteten Subtanzen hat Berberin die beste Wirkung bewiesen. Nach weiterer Testung könnte eine Anwendung mit Berberin als in vitro Präkonditionierung von MSC vielversprechend sein. Die Verwendung von Niclosamid hingegen sollte vermieden werden, die Wirkung von Gedunin müsste genauer untersucht werden.
Das Schilddrüsenkarzinom (SK) ist die häufigste bösartige endokrine Tumorerkrankung. Während das nicht-metastasierte und nicht-mutierte papilläre Schilddrüsenkarzinom (PSK) und das follikuläre Schilddrüsenkarzinom (FSK) eine gute Heilungschance aufweisen, zeigen die mutierten und metastasierten Varianten des PSK und FSK sowie das anaplastische Schilddrüsenkarzinom (ASK) weiterhin eine schlechte Prognose. Die Entwicklung von Therapieresistenzen stellen hierbei ein Hauptproblem in der Behandlung des fortgeschrittenen Schilddrüsenkarzinoms dar.
In den letzten Jahren wurden in Studien zunehmend Tumor-initiierende Zellen (TIZ) beschrieben, welche eine kleine Subpopulation von Zellen mit der Fähigkeit zur Selbsterneuerung, Tumorinitiierung und Entwicklung von Therapieresistenzen von Tumoren darstellen. Die Existenz von TIZ wurde auch im SK nachgewiesen. Ein entscheidender Faktor für die Persistenz von TIZ ist die Hypoxie, welche über eine Veränderung des Tumormikromilieus und des Zellmetabolismus zur Entstehung von Therapieresistenzen beiträgt. Ein durch Hypoxie hochreguliertes Enzym ist die Carboanhydrase IX (CAIX). CAIX wird hauptsächlich von Tumorzellen exprimiert und katalysiert die Reaktion von Kohlendioxid zu Bicarbonat und einem Proton und trägt damit zur Säurepufferung der Tumorzelle bei. CAIX stellt somit einen entscheidenden Faktor für das Überleben von Tumorzellen in einem hypoxischen Milieu dar. Des Weiteren ist eine erhöhte Expression von CAIX mit einem schlechten Patienten-Outcome assoziiert, wie z.B. im Brustkrebs. Diese Eigenschaften machen CAIX zu einem attraktiven Angriffspunkt einer zielgerichteten Tumortherapie. Die vorliegende Studie hat zum Ziel, die Expression von CAIX sowie dessen biologische Rolle im Schilddrüsenkarzinom näher zu untersuchen.
Hierzu wurden Proben von 114 SK-Patienten immunhistochemisch auf eine CAIX-Expression untersucht und mit tumorfreiem Schilddrüsengewebe verglichen. Hierbei waren unterschiedliche SK-Subtypen vertreten. Für eine weitere Validierung der Expressionsdaten erfolgte die Auswertung eines Datasets von „The Cancer Genome Atlas“ (TCGA) mithilfe von cBioportal. Da die Hypoxie ein wichtiger Faktor für die Persistenz von TIZ ist, wurde die CAIX-Expression in Tumorsphären, ein in vitro Nachweis von TIZ-Aktivität, mittels der Durchflusszytometrie bestimmt und mit der CAIX-Expression von Monolayern verglichen. Als SK-Zelllinien wurden BCPAP (PSK), FTC 133 (FSK) und 8505 C (ASK) verwendet. Anschließend wurde mithilfe der Polymerasekettenreaktion und Immunofluoreszenzfärbung untersucht, ob eine CAIX-Expression in den Tumorsphären mit der Expression von bereits bekannten Stammzellmarkern, u.a. NANOG, assoziiert ist. Die Unterschiede der CAIX-Expression, nach Inkubation der Monolayer jeweils in Normoxie und Hypoxie, wurden mittels Durchflusszytometrie bestimmt. Mithilfe eines genetischen CAIX-Knockdowns sowie einer pharmakologischen Inhibition mit dem CAIX-Inhibitor Methazolamid (MZM) wurde die Tumorzellproliferation und -Sphärenbildung unter Normoxie und Hypoxie bestimmt. Zusätzlich wurde der Einfluss von MZM auf die Apoptose und den Zellzyklus untersucht.
Immunhistochemische Färbungen der Gewebeproben von SK-Patienten zeigten, dass die CAIX-Expression sowohl im PSK und FSK als auch im ASK im Vergleich zum tumorfreien Schilddrüsengewebe erhöht war. Des Weiteren zeigte die klinisch-pathologische Datenanalyse, dass eine erhöhte CAIX-Expression mit dem Auftreten von Lymphknotenmetastasen im differenzierten SK assoziiert war. Auch die Analyse des TCGA-Datasets bestätigte, dass eine erhöhte Expression der CAIX-mRNA mit einem fortgeschrittenen Tumorstadium, Fernmetastasen und mit einem kürzeren Gesamt-Überleben von SK-Patienten korrelierte. Die weiteren funktionellen in vitro Untersuchungen ergaben, dass die CAIX-Expression in den Tumorsphären im Vergleich zu Monolayern erhöht und mit einer erhöhten Expression von Stammzellmarkern assoziiert war. Ein genetischer CAIX-Knockdown und eine CAIX-Inhibition mit MZM führten über eine Induktion der Apoptose und eines Zellzyklusarrests zu einer verminderten Tumorzellproliferation und Sphärenbildung.
Zusammenfassend deuten die Ergebnisse darauf hin, dass CAIX ein vielversprechendes Zielmolekül für eine gezielte Tumortherapie des fortgeschrittenen SK ist. Um diese Hypothese bestätigen zu können, sind jedoch weitere prospektive Analysen von Patientenproben sowie funktionelle in vivo Untersuchungen am SK nötig.
Einleitung: Die Zentrale Notaufnahme (ZNA) stellt eine Schnittstelle zwischen prä- und innerklinischer Versorgung dar. Das Spektrum der Krankheitsbilder erstreckt sich über jegliche Fachrichtungen und variiert von harmlosen Banalitäten bis zu akuten Notfällen. Eine sichere und suffiziente Primärversorgung ist die Basis eines qualitativ-hochwertigen Gesundheitssystems.2 Verspätete oder falsche Diagnosen in der ZNA sind mit 10-30 % keine Seltenheit.
Dies ist nicht nur für den individuellen Patienten belastend, es bedeutet auch einen zusätzlichen Ressourcenverbrauch und eine finanzielle Belastung für das Gesundheitssystem. Clinical Decision Support Systems (CDSS) haben das Potenzial, sowohl professionelle Anwender als auch Laien bei ihrer Diagnosefindung zu unterstützen. Fragestellung: Ziel der Arbeit ist es herauszufinden, welchen Einfluss der Diagnosezeitpunkt auf das Outcome von Patienten mit Abdominalschmerzen in der ZNA hat und inwiefern ein CDSS das Potenzial hat, die genannten Punkte zu beeinflussen.
Methoden: Es handelte sich um eine prospektive, doppelt verblindete Beobachtungsstudie. Patienten, die sich mit Abdominalschmerzen in der Notaufnahme vorstellten, gaben ihre Symptome in die Ada-App ein. Sowohl die Diagnosevorschläge der App als auch die Verdachtsdiagnosen des behandelnden Arztes wurden dokumentiert und verglichen. Weitere erhobene Parameter waren die Verwendung von apparativer Diagnostik, die vergangene Zeit bis zur endgültigen Diagnosestellung, das Auftreten von Komplikationen, die Komorbidität und Mortalität sowie die Länge des Krankenhausaufenthalts. Das Follow-Up erfolgte zu verschiedenen Zeitpunkten bis zu Tag 90. Für die Analyse wurden die 450 Patienten anhand des Zeitpunkts ihrer Diagnosestellung in Gruppen "früh" (Tag 0) und "spät" (Tag 1-24) eingeteilt.
Ergebnisse: Im Vergleich zur „frühen“ Gruppe, hatte die Gruppe der „spät“ diagnostizierten Patienten einen höheren Anteil von Männern (45.2% (n=168/372) versus 60.3 % (n=47/78); p=0.018), im Schnitt einen höheren Charlson Comorbidity Index (0.7 versus 1.1; p=0.045) und im Schnitt einen höheren RAI-C Score (8.06 versus 9.9; p<0.001) am Tag ihrer Vorstellung. Bei den „spät“ diagnostizierten blieben weniger Patienten komplikationsfrei (57.0 % 49 (n=212/372) versus 17.9% (n=14/78); p<0.001), es traten mehr Major-Komplikationen auf (8.9% (n=33/372) versus 17.9% (n=14/78); p=0.024), analog dazu war der Comprehensive Complication Index höher (13.1 versus 25.6; p<0.001) und sie verweilten länger im Krankenhaus (2.6 Tage versus 6.7 Tage; p<0.001). Zudem nahmen sie signifikant mehr apparative Diagnostik in Anspruch.
Die behandelnden Ärzte konnten in 82.6% der Fälle (n=372/450) am Tag der Vorstellung die korrekte Diagnose stellen. Die Ada-App konnte in insgesamt 52% der Fälle (n=234/450) die korrekte Diagnose unter ihren Diagnoseverschlägen nennen.
Schlussfolgerung: Multimorbide Patienten scheinen anfälliger zu sein für falsche und verspätete Diagnosen. Ein später Diagnosezeitpunkt korreliert mit der vermehrten Nutzung apparativer Diagnostik, einem komplikationsreicheren Verlauf, einer höheren Komorbidität und einem längeren Krankenhausaufenthalt.
Die Ada-App ist den Ärzten zwar unterlegen, dennoch ist Potenzial vorhanden.
Für Ärzte kann die Ada-App eine Unterstützung im Rahmen der Diagnosefindung darstellen. Neben der Ressourcenentlastung kann sie vor Fehlannahmen und frühzeitigen Schlussfolgerungen schützen und auf weitere mögliche Differentialdiagnosen hinweisen. Die Ada-App stellt für Laien mit Sicherheit eine Weiterentwicklung gegenüber der simplen Symptomsuche über das Internet dar, dennoch sollten weitere Studien den Nutzen und die Sicherheit der App überprüfen.
This work aimed to investigate the regulation and activity of 5-lipoxygenase (5-LO), the central enzyme in leukotriene biosynthesis, in two colorectal cancer cell lines. The leukotriene pathway is positively correlated with the progression of several solid malignancies; however, factors regulating 5-LO expression and activity in tumors are poorly understood.
Cancer development, as well as cancer progression, are strongly dependent on the tumor microenvironment. In the conventional monolayer culture of cancer cell lines, cell-matrix and cell-cell interactions present in native tumors are absent. Furthermore, it is already known that various colon cancer cell lines dysregulate several important signaling pathways due to 3D growth. Therefore, the expression of the leukotriene cascade in HT-29 and HCT-116 colorectal cancer cells was investigated within a three-dimensional context using multicellular tumor spheroids to mimic a more physiological environment compared to conventional cell culture. Especially the expression of 5-LO, cPLA2α, and LTA4 hydrolase was altered due to threedimensional (3D) cell growth, which was investigated by qPCR and Western blot analysis. High cellular density in monolayer cultures led to similar results. The observed 5-LO upregulation was found inversely correlated with cell proliferation, determined by cell cycle analysis, and activation of PI3K/mTORC-2- and MEK-1/ERK-dependent pathways, determined using pharmacological pathway inhibition, stable shRNA knockdown cell lines, and analysis via qPCR and Western blot analysis. Following, the transcription factor E2F1 and its target gene MYBL2 were identified to play a role in the repression of 5-LO during cell proliferation. For this purpose, several stable MYBL2 over-expression and ALOX5 reporter cell lines were prepared and analyzed. Since 5-LO was already identified as a direct p53 target gene, the influence of p53, which is variably expressed in the cell lines (HT-29, p53 R273H mut; HCT-116 p53 wt; HCT-116 p53 KO), was investigated as well. Furthermore, HCT-116 cells carrying a p53 knockout were investigated. The PI3K/mTORC-2- and MEK-1/ERK-dependent suppression of 5-LO was also found in tumor cells from other origins (Capan-2, Caco-2, MCF-7), which was determined using pharmacological pathway inhibition and following analysis via qPCR. This suggests that the identified mechanism might apply to other tumor entities as well.
5-LO activity was previously described as attenuated in HT-29 and HCT-116 cells compared to polymorphonuclear leukocytes, which express a highly active 5-LO. However, the present study showed that the enzyme activity is indeed low but inducible in HT-29 and HCT-116 cells. Of note, the general lipid mediator profile and the mediator concentrations were comparable to those of M2 macrophages. Finally, the analysis of substrate availability in HT-29 and HCT-116 cells revealed a vast difference between formed metabolite concentrations and supplemented fatty acid concentrations, indicating that the substrates are either transformed into lipoxygenase-independent metabolites or are esterified into the cellular membrane.
In summary, the data presented in this work demonstrate that 5-LO expression and activity are tightly regulated in HT-29 and HCT-116 cells and fine-tuned due to environmental conditions. The cells suppress 5-LO during proliferation but upregulate the expression and activity of the enzyme under cellular stress-triggering conditions. This implies a possible role of 5-LO in manipulating the tumor stroma to support a tumor-promoting microenvironment.
Weltweit gibt es laut WHO ca. 58 Millionen Menschen mit einer chronischen Hepatitis-C-Virus (HCV) Infektion und jährlich stecken sich ca. 1,5 Millionen Menschen neu mit diesem Virus an (Stand 2019). Da die Folge einer chronischen Hepatitis-C-Virus Infektion eine potenziell tödlich verlaufende Leberzirrhose oder die Entwicklung eines Hepatozellulären Karzinoms sein können, ist eine frühe Diagnose und eine adäquate Therapie eine wichtige Aufgabe in der Medizin.
Die bisherige Therapie erfolgte mittels pegyliertem Interferon und Ribavirin und seit einigen Jahren auch interferonfrei mittels Direkter Antiviraler Agenzien (DAA). Vor allem beim älteren Therapieregime konnten viele Nebenwirkungen und häufiger auch ein Therapieversagen auftreten, sodass ein leicht zu gewinnender Biomarker nützlich wäre, der die Patienten mit Therapieversagen frühzeitig und im besten Fall sogar vor Therapiebeginn detektieren kann.
In der vorliegenden Arbeit wurden die Spiegel von extrazellulär im Blut zirkulierender, leberspezifischer microRNA miR-122 auf Eigenschaften als solche potenzielle Biomarker untersucht. Dazu wurden die Patientenseren von insgesamt 60 Patienten mit chronischer Hepatitis-C-Virus Infektion analysiert, die mittels pegyliertem Interferon und Ribavirin behandelt wurden. Vor, während und nach der Therapie wurden verschiedene Laborparameter sowie die miR 122 in den Patientenseren bestimmt. 20 dieser Patienten zeigten ein dauerhaftes Ansprechen auf die Therapie (sustained virological response = SVR), 20 zeigten nach einem initialen Therapieansprechen ein Rückfall der Erkrankung (Relapse) und 20 Patienten sprachen gar nicht auf die Therapie an (Non-Responder = NR).
Zunächst wurden die sogenannten Baseline-Charakteristika der Patienten vor Therapiebeginn untersucht. Dabei konnten wir jedoch keinen Unterschied zwischen den Patientengruppen hinsichtlich der Alanin-Aminotransferase (ALT) und Aspartat-Aminotransferase (AST), zwei Laborparameter zur Bestimmung einer Leberschädigung, sowie der HCV-RNA, ein Parameter zur Bestimmung der Viruslast bei Patienten mit einer HCV-Infektion, feststellen.
Auch die miR-122-Spiegel zeigten vor Therapiebeginn keinen signifikanten Unterschied zwischen den drei Patientengruppen. Daraus wurde geschlossen, dass man die miR-122 vor Therapiebeginn nicht als prognostischen Marker für einen Therapieerfolg verwenden kann.
Beim Vergleich der miR-122-Spiegel mit den Laborparametern konnte eine signifikante Korrelation zwischen der miR-122 und der ALT, AST und der Gamma-Glutamyl-Transferase (GGT) festgestellt werden. Die miR-122 scheint somit ähnlich wie die anderen Laborparameter eine Leberzellschädigung widerzuspiegeln.
Nach dem Therapiebeginn konnte bereits ab Woche 4 ein signifikanter Unterschied zwischen den SVR und Non-Respondern sowie zwischen den Relapsepatienten und den Non-Respondern festgestellt werden. Jedoch war der Unterschied zwischen den SVR und den Relapse-Patienten nicht signifikant, sodass man weiterhin keine Unterscheidung dieser beiden Patientengruppen machen konnte.
Auch die ALT- und HCV-RNA-Spiegel zeigten einen ähnlichen Verlauf. In den Gruppen der SVR und Relapse-Patienten zeigte sich im Laufe der Therapie ein Rückgang der Parameter wohingegen die Gruppe der Non-Responder keine signifikante Dynamik aufwies.
Zum Schluss wurden die miR-122-Spiegel 12 bzw. 24 Wochen nach Therapieende bestimmt, dem sogenannten Zeitpunkt des Follow-Up bei dem der Therapieerfolg laut Leitlinie mit Hilfe der HCV-RNA-Messung bestimmt wird. Dabei konnte ein signifikanter Unterschied zwischen den miR-122-Spiegeln bei den SVR-Patienten und den anderen beiden Patientengruppen festgestellt werden.
In Zusammenschau dieser Ergebnisse kann man sagen, dass die miR-122 gut geeignet ist um ähnlich wie die HCV-RNA den Therapieverlauf widerzuspiegeln. Als prognostischer Parameter bzw. Biomarker für ein Therapieansprechen ist sie jedoch nicht geeignet, da keine Unterscheidung zwischen den einzelnen Patientengruppen vor Therapiebeginn möglich ist und während der Therapie lediglich die Non-Responder und nicht die Relapse-Patienten detektiert werden können.
Im Fokus der vorliegenden Arbeit stand die Fragestellung, inwieweit ORF10 von B. recurrentis, dem Erreger des Läuserückfallfiebers, mit verschiedenen Komplementkomponenten interagieren kann.
Mit funktionellen Komplementtests konnte gezeigt werden, dass ORF10 den klassischen, den alternativen sowie den Lektin-Weg inhibiert, wobei sich die stärkste Inhibition gegenüber dem alternativen Weg manifestierte. Darüber hinaus ließ sich in einem Zell-basierten Hämolyse-Assay eine Inhibition des terminalen Komplementweges durch ORF10 nachweisen.
Die durchgeführten Bindungsanalysen mit verschiedenen Komplementkomponenten führten zu dem Ergebnis, dass ORF10 mit C1q, C1s, C3, C3b, C4b und C5 interagiert und diese Protein-Protein-Interaktion mit den Komplementkomponenten C1q, C3, C3b und C4b durch einen dosisabhängigen Verlauf charakterisiert ist. Eine Bindung von C1r, C2, C4, FB, FH sowie FI konnte jedoch nicht nachgewiesen werden.
Auf Basis der modellierten Struktur von ORF10 wurden mithilfe der In-vitro-Mutagenese drei verschiedene Varianten generiert, die jedoch nicht affinitätschromatographisch aus E. coli-Zelllysaten isoliert werden konnten und deshalb nicht für weiterführende funktionelle Analysen zur Verfügung standen.
Die Ergebnisse der Serumbakterizidie-Tests mit einem „gain of function“-Borrelienstamm, welcher ORF10 heterolog produzieren sollte, ergaben, dass keine erhöhte Resistenz gegenüber Humanserum nachgewiesen werden konnte. Inwieweit ORF10 bei der intrinsischen Serumresistenz von B. recurrentis beteiligt ist, lässt sich abschließend nicht vollumfänglich erklären.
Background: Survival data regarding cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) patients according to the type and extent of tumor-associated vascular thrombus are scarce.
Objective: To test for survival differences in mRCC patients treated with CN according to the type and extent of tumor-associated vascular thrombus.
Design, setting, and participants: Within Surveillance, Epidemiology, and End Results Research Plus (2004–2017), we identified CN mRCC patients with renal vein (pT3a-TT) versus infradiaphragmatic inferior vena cava (IVC; pT3b) versus supradiaphragmatic IVC tumor thrombus/IVC invasion (pT3c).
Outcome measurements and statistical analysis: Overall survival (OS) was addressed in Kaplan-Meier and Cox regression analyses, in addition to 3-mo landmark analyses.
Results and limitations: Of 2170 mRCC patients, 1880 (87%), 204 (9%), and 86 (4%) harbored pT3a-TT, pT3b, and pT3c, respectively. The respective median OS periods were 21, 23, and 12 mo (p < 0.001). In multivariable Cox regression models, pT3c stage, but not pT3b stage, was an independent predictor of higher overall mortality (hazard ratio [HR]: 1.37; 95% confidence interval [CI]: 1.09–1.73; p = 0.007), as well as in 6-mo landmark analyses (HR: 1.36; 95% CI: 1.02–1.80; p = 0.04). In the sensitivity analysis, relying on all pT3a patients, the predictor status of pT3c stage remained unchanged (HR: 1.37; 95% CI: 1.09–1.71; p = 0.007). Limitations have to be addressed regarding the sample size and the retrospective design of the current study.
Conclusions: Although overall mortality is significantly higher in pT3c mRCC patients than in their pT3b and pT3a-TT counterparts, these individuals may still expect 12-mo or better OS after CN versus virtually 2-yr OS in their pT3a and pT3b counterparts.
Patient summary: In this study, we looked at the survival outcomes of metastatic renal cell carcinoma patients who presented with tumor thrombus at cytoreductive nephrectomy. Even though these patients with most advanced tumor thrombus stage demonstrated lower survival rates, the median overall survival was still 1 yr.
Middle-aged persons with multimorbidity have to take their illnesses into account in their daily work, family and leisure activities. The MuMiA project aims to identify early preventive measures that make it easier for those between 30 and 60 years of age with multiple chronic diseases to manage their illnesses in their everyday lives. An interdisciplinary workshop and interviews with multimorbid middle-aged adults and their principal healthcare providers will be used to collect information on the management of care in the contexts of patients’ daily work, family and leisure activities. Data obtained in the interviews will be coded inductively and analysed using content analysis. Workshop outputs will be transcribed and evaluated by the authors. This study has received ethical approval from the Faculty of Medicine Ethics Committee of Goethe University (2021-47). The project will generate prevention recommendations that reflect the experiences of middle-aged persons living with multimorbidity and the views of their principal healthcare providers. The findings will be disseminated via conferences and peer-reviewed publications.
Development of a multidimensional pain questionnaire in professional dance (MPQDA): a pilot study
(2022)
Background: Pain is part of the everyday life of professional dancers. It can indicate health risks and impair the ability to work. Suitable screening tools can be used to identify pain and its risk potential. A comprehensive, multidimensional, differentiated assessment tool for pain in professional dance does not currently exist.
Methods: An initial questionnaire was developed in German and English and was assessed in a qualitative pretest. In a field study with a cross-sectional design including n = 72 dancers from Germany (n = 36 responses each in the English and German language versions), the questionnaire was optimized by item analysis, its psychometric properties (dimensionality, construct validity, reliability) were examined and the ability of the pain dimensions to classify the subjective ability to work in training was analyzed (ROC analysis).
Results: The developed Multidimensional Pain Questionnaire in Professional Dance (MPQDA) was reduced and optimized in its psychometric properties. Following questions were reduced in their items or answer categories: pain localizations (from 20 to 15 regions), accompanying symptoms (from 6 to 3 items), sensory and affective pain quality (from 20 to 10 items), pain frequency (from 4 to 3 answer categories), and the motives of working with pain (from 14 to 12 items). Regarding the subjective ability to work in training, the variables of the ability to work in rehearsals and in performances, as well as the accompanying symptoms of tension and mobility restrictions, showed a relatively good classification ability (Area under the Curve (AUC) ≥ 0.7 in the 95% confidence interval) and significant, moderate to strong correlations (Somers' D > 0.25, p < 0.05). The classification ability of the other pain dimensions was largely absent or poor.
Conclusion: The MPQDA differentiates various pain dimensions in professional dancers and is available in a compatible manner in German and English. The clinical relevance needs to be explored further in the future.
Up to the present, there has been a lack of studies on the skin health of professional and recreational dancers. Dancers are at risk of skin diseases due to contact with allergenic or irritating substances and working in humid environments. The aim of the present study was, therefore, to examine skin health in two different dance styles and training periods. Methods: Physical dermatological examination of professional dancers (PD; n = 35) and Latin American formation dancers (LD; n = 79) after a 4-week period of recovery (T0) and a period of high training or work load (T1). Results: PD are significantly more frequently affected by skin dermatoses than LD (T0, p = 0.004) (frontal traction alopecia, hair loss, facial seborrhoea, xerosis cutis of the trunk and extremities, and facial folliculitis). The following significant differences between the sexes were observed in the LD: more folliculitis of the trunk in male subjects (T0 and T1, p = 0.009), more frequent xerosis cutis of the extremities (p < 0.001) and perioral dermatitis in female subjects (T1, p = 0.043). Subjects with skin lesions trained more frequently, performed more times per year, and had longer dance experience. Discussion: Based on the findings, preventive measures for skin protection (especially informing dancers about skin health) are necessary. At the same time, further studies on this topic are important.
The deep fascia is intimately linked to skeletal muscle and may be involved in delayed onset muscle soreness (DOMS). The present study therefore explored the effect of eccentric exercise on fascia stiffness and its relation with DOMS. Healthy active male adults (n = 19, 27 ± 4 years) performed 6 x 10 maximal eccentric knee flexions using an isokinetic dynamometer. Before (baseline) as well as immediately (T0), 1 hour (T1), and each day up to 72 hours (T24 to T72) afterwards, shear wave elastography was used to measure the mechanical stiffness of the biceps femoris muscle and the overlying fascia. As a surrogate of DOMS, pain upon palpation was captured by means of a 100mm visual analogue scale. While muscle stiffness remained unchanged (p > 0.05), deep fascia stiffness increased from baseline to T24 (median: 18 kPa to 21.12 kPa, p = 0.017) and T72 (median: 18 kPa to 21.3 kPa, p = 0.001) post-exercise. Linear regression showed an association of stiffness changes at T24 and pressure pain at T72 (r2 = 0.22, p < 0.05). Maximal eccentric exercise leads to a stiffening of the fascia, which, in turn, is related to the magnitude of future DOMS. Upcoming research should therefore gauge the effectiveness of interventions modifying the mechanical properties of the connective tissue in order to accelerate recovery.
Background: Primary viral myocarditis associated with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection is a rare diagnosis.
Case presentation: We report the case of an unvaccinated, healthy patient with cardiogenic shock in the context of a COVID-19-associated myocarditis and therapy with simultaneous veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and percutaneous left ventricular decompression therapy with an Impella. The aim of this review is to provide an overview of therapeutic options for patients with COVID-19-associated myocarditis.
Conclusions: The majority of patients required a combination of two assist devices to achieve sufficient cardiac output until recovery of left ventricular ejection fraction. Due to the rapid onset of this fulminant cardiogenic shock immediate invasive bridging therapy in a specialized center was lifesaving.
Introduction: Studies of vocational ballet students are sparce. In particular, there is a lack of gender comparisons. The aim of the present study, therefore, was to give a musculoskeletal and sociodemographic description of the typical vocational ballet student in gender comparison. Methods: In this study, n = 414 female and n = 192 male students of the John Cranko School (JCS), aged between 5 and 22 years (Mean ± SD: 13.9 ± 3.5), were examined by an experienced orthopedist and dance physician. Results: Males started ballet (5.8/8.2 years, p < 0.001) and training at later age than females (13.5/14.6 years, p < 0.05). There was a high prevalence of low body weight among both sexes; however, particularly among female participants (58.4/16.2%, p < 0.001). Both sexes showed a large external rotation of the hip (f/m: 59/62°, p < 0.001), a large turnout (f/m: 82/86°, p < 0.01), high values for plantarflexion of the ankle joint (f/m: 72/68°, p < 0.001) and dorsiflexion of the metatarsophalangeal joint of the big toe (f/m: 90/87°, p < 0.001). Discussion: Differences in ballet-specific characteristics between genders (f/m) are converging and are smaller than described in the past. The particularly high prevalence of low body weight among students in the vocational training sector, particularly among females, highlights the need for deeper diagnostic investigation.
Cortical tracking of stimulus features (such as the envelope) is a crucial tractable neural mechanism, allowing us to investigate how we process continuous music. We here tested whether cortical and behavioural tracking of beat, typically related to rhythm processing, are modulated by pitch predictability. In two experiments (n=20, n=52), participants’ ability to tap along to the beat of musical sequences was measured for tonal (high pitch predictability) and atonal (low pitch predictability) music. In Experiment 1, we additionally measured participants’ EEG and analysed cortical tracking of the acoustic envelope and of pitch surprisal (using IDyOM). In both experiments, finger-tapping performance was better in the tonal than the atonal condition, indicating a positive effect of pitch predictability on behavioural rhythm processing. Neural data revealed that the acoustic envelope was tracked stronger while listening to atonal than tonal music, potentially reflecting listeners’ violated pitch expectations. Our findings show that cortical envelope tracking, beyond reflecting musical rhythm processing, is modulated by pitch predictability (as well as musical expertise and enjoyment). Stronger cortical surprisal tracking was linked to overall worse envelope tracking, and worse finger-tapping performance for atonal music. Specifically, the low pitch predictability in atonal music seems to draw attentional resources resulting in a reduced ability to follow the rhythm behaviourally. Overall, cortical envelope and surprisal tracking were differentially related to behaviour in tonal and atonal music, likely reflecting differential processing under conditions of high and low predictability. Taken together, our results show diverse effects of pitch predictability on musical rhythm processing.
Structural brain morphometry as classifier and predictor of ADHD and reward-related comorbidities
(2022)
Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, and around two-thirds of affected children report persisting problems in adulthood. This negative trajectory is associated with high comorbidity with disorders like obesity, depression, or substance use disorder (SUD). Decreases in cortical volume and thickness have also been reported in depression, SUD, and obesity, but it is unclear whether structural brain alterations represent unique disorder-specific profiles. A transdiagnostic exploration of ADHD and typical comorbid disorders could help to understand whether specific morphometric brain changes are due to ADHD or, alternatively, to the comorbid disorders. In the current study, we studied the brain morphometry of 136 subjects with ADHD with and without comorbid depression, SUD, and obesity to test whether there are unique or common brain alterations. We employed a machine-learning-algorithm trained to classify subjects with ADHD in the large ENIGMA-ADHD dataset and used it to predict the diagnostic status of subjects with ADHD and/or comorbidities. The parcellation analysis demonstrated decreased cortical thickness in medial prefrontal areas that was associated with presence of any comorbidity. However, these results did not survive correction for multiple comparisons. Similarly, the machine learning analysis indicated that the predictive algorithm grouped most of our ADHD participants as belonging to the ADHD-group, but no systematic differences between comorbidity status came up. In sum, neither a classical comparison of segmented structural brain metrics nor an ML model based on the ADHD ENIGMA data differentiate between ADHD with and without comorbidities. As the ML model is based in part on adolescent brains, this might indicate that comorbid disorders and their brain changes are not captured by the ML model because it represents a different developmental brain trajectory.
Objectives: The range of motion (ROM) of the cervical spine and postural stability are important for an economical and motorically adequate adaptation of the body to any situation. Therefore, this study aims to analyze whether these two components of postural and movement control can be influenced by means of a splint in a centric position compared to habitual occlusion.
Methods: 38 recreational male athletes volunteered. Cervical spine ROM was recorded using an ultrasound system and the a pressure measuring plate for postural stability (length of center of pressure (CoP) movement, area of CoP). The two dental occlusion conditions employed were the habitual occlusion and wearing a splint in an idealized, condylar position close to the centric position. Level of significance was set at ρ ≤ 0.05.
Results: The cervical spine mobility increased significantly by wearing the splint regarding rotation to the left (+3.9%) and right (+2.7%) and lateral flexion to the left (+4.4%) and right (+6.7%). Wearing the splint reduced the area of sway deflections by about 31.5% in the bipedal stance and by about 2.4% (left) and 28.2% (right) in the unipedal stance. The CoP trace was reduced in the sagittal plane by approximately 8.2% in the right single-leg stance.
Conclusions: The major findings seem to demonstrate that wearing a splint that keeps the jaw close to the centric relation may increase the cervical ROM and may improve balance stability in male recreational athletes. Changing the jaw relation in athletes can possibly aid the release of performance potentials by improving coordination skills.
Background: In order to determine possible pathological deviations in body weight distribution and body sway, it is helpful to have reference values for comparison: gender and age are two main influencing factors. For this reason, it was the aim of the present study to present reference values for women between 51 and 60 years of age.
Methods: For this study, 101 subjectively healthy female Germans aged between 51 and 60 years (55.16 ± 2.89 years) volunteered and were required to stand in a habitual posture on a pressure measuring platform.
Results: The average BMI of this age group was 25.02 ± 4.55 kg/m². The left and right foot showed an almost evenly balanced load distribution with a median load of 52.33% on the left foot [tolerance interval (TR) 38.00%/68.03%; confidence interval (CI) 51.00%/53.33%] and 47.67% on the right foot [TR 31.97%/62.00%; CI 46.67%/49.00%]. The measured median load of the forefoot was 33.33% [TR 21.37%/54.60%; CI 30.67%/36.00%] and that of the rear foot was 66.67% [TR 45.50%/78.63%; CI 64.00%/69.33%]. The median body sway in the frontal plane was 11 mm [TR 5.70 mm/26.30 mm; CI 10.00 mm/11.67 mm] and that of the sagittal plane was 16 mm [TR 7.37 mm/34.32 mm; CI 14.67 mm/18.67 mm]. The median ellipse area was 1.17 cm² [TR 0.29 cm²/4.96 cm²; CI 0.98 cm²/1.35 cm²], the median ellipse width was 0.91 cm [TR 0.42 cm/1.9 cm; CI 0.84 cm/1.02 cm] and its height was 0.40 cm [TR 0.22 cm/0.89 cm; CI 0.38 cm/0.43 cm].
Conclusions: The left-to-right ratio is almost balanced. The load distribution of the forefoot to the rear foot is approximately 1:2. The median body sway values for the frontal and sagittal planes (11 and 16 mm, respectively) agree with other values. The values for the height, body weight and the BMI are comparable to the values of average German women at this age; therefore, the measured values show a presentable cross section of women in the 51–60 age group in Germany. The present data can be used as a basis for women aged 51–60 years and can support the detection of possible dysfunctions as well as injury prevention in the parameters of postural control.
Background: In the COVID-19 pandemic, numerous researchers postponed their patient and public involvement (PPI) activities. This was mainly due to assumptions on patients’ willingness and skills to participate digitally. In fact, digital PPI workshops differ from in-person meetings as some forms of non-verbal cues and body language may be missing and technical barriers may exist. Within our project HYPERION-TransCare we adapted our PPI workshop series for intervention development to a digital format and assessed whether these digital workshops were feasible for patients, health care professionals and researchers.
Methods: We used a digital meeting tool that included communication via audio, video and chat. Discussions were documented simultaneously on a digital white board. Technical support was provided via phone and chat during the workshops and with a technical introduction workshop in advance. The workshop evaluation encompassed observation protocols, participants’ feedback via chat after each workshop on their chance to speak and the usability of the digital tools, and telephone interviews on patients’ and health professionals’ experiences after the end of the workshop series.
Results: Observation protocols showed an active role of moderators in verbally encouraging every participant to get involved. Technical challenges occurred, but were in most cases immediately addressed and solved. Participants median rating of their chance to speak and the usability of the digital tool was “very good”. In the evaluation interviews participants reported a change of perspective and mutual understanding as a main benefit from the PPI workshops and described the atmosphere as inclusive and on equal footing. Benefits of the digital format such as overcoming geographical distance, saving time and combining workshop participation with professional or childcare obligations were reported. Technical support was stressed as a pre-condition for getting actively involved in digital PPI.
Conclusions: Digital formats using different didactic and documentation techniques, accompanied by technical support, can foster active patient and public involvement. The advantages of digital PPI formats such as geographical flexibility and saving time for participants as well as the opportunity to prepare and hold workshops in geographically stretched research teams persists beyond the pandemic and may in some cases outweigh the advantages of in-person communication.
Although, during the past decades, substantial advances emerged in identifying major local and systemic factors contributing to initiation and progression of osteoarthritis (OA), some neuroendocrine mechanisms are still not understood or even neglected when thinking about novel therapeutic options. One of which is the sympathetic nervous system that exhibits various OA-promoting effects in different tissues of the joint. Interestingly, the β2-adrenoceptor (AR) mediates the majority of these effects as demonstrated by several in vitro, in vivo as well as in clinical studies. This review article does not only summarize studies of the past two decades demonstrating that the β2-AR plays an OA-promoting role in different tissues of the joint but also aims to encourage the reader to think about next-level research to discover novel and innovative preventive and/or therapeutic strategies targeting the β2-AR in OA.
Das Hepatoblastom ist ein embryonaler Lebertumor, dessen Zellen unterschiedliche unreife Stadien aufweisen. Aufgrund dieser Unreife ist die Identifizierung von Krebsstammzellen erschwert, die in diesem Tumor vermutet und für Rückfälle verantwortlich gemacht werden. In Vorarbeiten konnte eine Krebsstammzellpopulation mit der Kombination der hämatopoetischen Stammzellmarker CD90 und CD34 sowie dem „oval cell“ OV-6-Antikörper in den etablierten Hepatoblastomzelllinien HuH6 und HepG2 detektiert werden. Diese CD34+OV-6+CD90+ Zellen wiesen eine erhöhte Expression von Pluripotenzfaktoren auf und zeichneten sich durch ein erhöhtes Migrationsverhalten aus.
In der hier vorgelegten Arbeit wurden zunächst Tumor-Sphäroid-Assays durchgeführt um diese Population als Krebsstammzellen zu bestätigen, da nur Krebsstammzellen unter den gegebenen Umständen wachsen können. Diese waren im Anschluss wieder in der Lage, in „normalem Medium“ zu differenzieren. Des Weiteren wurden die Zelllinien mit dem Standardtherapeutikum Cisplatin behandelt. Da Krebsstammzellen als chemoresistent gelten, konnte in der überlebenden Zellpopulation auch eine Anreicherung der CD34+OV-6+CD90+ Zellen beobachtet werden. Zusätzlich ließ sich eine weitere CD34+OV-6+CD90+ Population identifizieren, deren Expression aller drei Marker schwächer war und die bei steigenden Cisplatin-Konzentrationen den Großteil der CD34+OV-6+CD90+ Population ausmachte.
Neben den erhöhten Transkriptmengen der Pluripotenzmarker Oct4 und Nanog zeichneten sich die CD34+OV-6+CD90+ Krebsstammzellen durch eine verstärkte Expression der aktivierungsinduzierten Zytidin-Desaminase AID aus. AID wirkt induzierend auf die Transkription beider Pluripotenzmarker. Daher könnte es auch bei Krebsstammzellen eine Rolle bei der Induktion von Pluripotenz und bei ihrer langfristigen Erhaltung spielen. Dies unterstützend legten die verminderten Transkriptmengen der Pluripotenzgene nach einem AID siRNA Knock-Down eine Abhängigkeit des Stammzellcharakters von diesem Faktor nahe. Um einen Effekt von Therapeutika, die inhibitorisch auf AID wirken, auf Krebsstammzellen zu untersuchen, wurden die Zellen mit den DNMT-Inhibitoren Decitabine und Zebularine sowie dem HSP90-Inhibitor Tanespimycin behandelt. Tatsächlich konnte vor allem in den HuH6-Zellen ein verminderter Anteil der Krebsstammzellpopulation durch die drei Substanzen beobachtet werden. Wurden die Zellen im Anschluss mit dem Standardzytostatikum Cisplatin behandelt, führte allerdings eine Vorbehandlung mit Zebularine oder Decitabine zu einer starken Anreicherung von Krebsstammzellen. Dies war vor allem auf Zellen mit dem schwach positiven CD34+OV-6+CD90+ Expressionsprofil zurückzuführen, die chemo-induziert zu sein scheinen. Zwar erscheint die Mehrheit der Tumorzellen eliminiert zu werden, jedoch lassen diese Ergebnisse die Entstehung von chemo-induzierten Krebsstammzellen vermuten, die langfristig für einen Rückfall verantwortlich sein könnten. Daher ist von einer Ergänzung der Therapie mit diesen Substanzen abzusehen. Eine Vorbehandlung mit Tanespimycin hingegen konnte im Vergleich zur alleinigen Cisplatin-Behandlung wirksam den Anteil der Krebsstammzellen reduzieren. Interessanterweise war dies nicht auf einen verstärkten Zelltod der Krebsstammzellen, sondern vielmehr auf eine durch Tanespimycin bewirkte Differenzierung derselben zurückzuführen. Diese spiegelte sich auch in einer verminderten Expression von Pluripotenzmarkern auf mRNA-Ebene im Vergleich zur alleinigen Cisplatin-Behandlung wider.
Somit präsentierte sich Tanespimycin als potenter Inhibitor von Krebsstammzellen. Auch wenn weitere vorklinische und klinische Tests und Untersuchungen erfolgen müssen, stellt Tanespimycin bzw. die Substanzklasse der HSP90-Inhibitoren einen interessanten und vielversprechenden Kandidaten für eine Ergänzung der Standardtherapie vor allem bei behandlungsresistenten und rekurrenten High-Risk-Hepatoblastomen dar.
Inflammation is a regulated reaction of the body to control a threat such as infection or injury. An efficient resolution of inflammation is critical to prevent the development of chronic inflammation and to restore tissue homeostasis. Macrophages (Mf) play a crucial role in the onset, but also in the resolution of inflammation, because they phagocytose and eliminate pathogens and tissue debris. Efficient efferocytosis, i.e. the engulfment of apoptotic cells, represents an important trigger for the onset of the resolution response and contributes to the pro-resolving reprogramming of Mf. Despite the importance of post- transcriptional modes of regulation during the resolution phase and translational control as a key node modulating gene expression in immune cells, relevant translational alterations remain largely elusive.
In the present study, I aimed to identify translationally regulated targets in inflammatory primary murine Mf upon resolution-promoting efferocytosis. To this end, I used total RNA-sequencing as well as de novo proteomics analyses to determine global transcriptional and translational changes. Sequencing data confirmed that efferocytosis induced a pro-resolution signature in inflammatory Mf and pointed towards translational regulation because the related integrated stress response was enriched upon efferocytosis. While changes of gene expression between efferocytic and non-efferocytic Mf appeared rather small at the transcriptional level, I observed considerable differences at the level of de novo synthesized proteins. This finding suggests a regulation at the level of translation. Furthermore, the tight connection between translational and metabolic changes was confirmed by enriched metabolism-associated terms of targets upregulated by efferocytosis at both RNA and de novo protein level. Interestingly, analysis of translationally regulated targets in response to inflammatory stimulation showed reduced translation for most targets, with only little impact of efferocytosis. Among those targets, I identified pro-resolving matrix metallopeptidase 12 (Mmp12) as a novel candidate, which showed translational repression during early inflammation and translational increase during the resolution phase. Noteworthy, a first indicator for a potential translation regulatory component of Mmp12 were the extremely high mRNA levels and not overly high de novo protein levels. Validation experiments recapitulated a slight elevation of Mmp12 mRNA expression and a significant downregulation of MMP12 intracellular protein levels in inflammatory Mf, as observed in the RNA-seq and de novo proteomics datasets. To investigate whether the discrepancy in mRNA and protein expression were due to changes in translation, I applied polysomal fractionation analysis to determine the translational status of Mmp12. Inflammatory Mf displayed a significantly lower relative Mmp12 mRNA abundance in the late polysomes compared to naïve Mf, suggesting reduced translational efficiency upon inflammatory stimulation. Consequently, extracellular MMP12 levels in the supernatant of inflammatory Mf decreased, although with a slight delay.
The functional impact of attenuated Mmp12 translation upon inflammatory stimulation was assessed in migration assays. While siRNA-mediated knockdown of Mmp12 did not alter Mf migration on uncoated plates, it increased migration 3-fold on matrigel/elastin-coated plates. Importantly, the increase in migrated distance driven by siMmp12 could be lowered by the addition of exogenous recombinant MMP12 protein. In line with reduced Mmp12 translation and MMP12 protein in inflammatory Mf, I observed a significant increase in cell migration on matrigel/elastin-coated plates, while it remained unaltered on uncoated plates. Consequently, Mf elastase MMP12 degrades elastin, thereby cell migration along elastin fibers is diminished. In inflammatory Mf, Mmp12 is translationally downregulated, thereby enhancing the migratory capacity.
In summary, the present study identifies a substantial contribution of translational regulation in the course of inflammation shown by high changes between inflammatory naïve and efferocytic Mf at the de novo proteomic level. Specifically, I was able to determine the translational regulation of pro-resolving Mmp12, which is repressed during early inflammation and recovers during the resolution phase. Functionally, translational control of MMP12 emerged as a strategy to alter the migratory properties of Mf, enabling enhanced, matrix- dependent migration of Mf during the early inflammatory phase, while restricting migration during the resolution phase.
Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects
(2022)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity. Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells. These AhR-independent effects are largely mediated by the Nrf2/SKN-1 pathway.
The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended.
Test-Retest-Reliabilität der Präpulsinhibition (PPI) und PPI-Korrelation mit dem Arbeitsgedächtnis
(2023)
Sensomotorisches Gating – ein Mechanismus zur Filterung des sensorischen Inputs und zur Regulierung des motorischen Outputs – wird experimentell durch die Präpulsinhibition (PPI) der akustisch ausgelösten Schreckreaktion (ASR) operatio-nalisiert. Frühere Studien deuten auf eine hohe Test-Retest-Reliabilität der PPI und eine mögliche Korrelation mit dem Arbeitsgedächtnis (engl. Working Memory (WM)) hin. Ziel dieser Studie war es, die Test-Retest-Reliabilität der PPI bei ge-sunden Menschen und ihre Korrelation mit der Leistung des WM zu überprüfen. Hier wurde ein akustisches Schreckreiz-PPI-Paradigma mit vier verschiedenen Präpuls-Intensitäten (64, 68, 72 und 76 dB(A)) und zwei verschiedene WM-Aufgaben (n-back, Change-Detection-Task (CDT)) verwendet. Es konnte eine ho-he Retest-Reliabilität der PPI mit einer mittleren Intraklassenkorrelation (engl. In-traclass Correlation (ICC)) von >.80 und eine signifikante positive Korrelation der PPI mit der n-back-, aber nicht mit der CDT-Leistung bestätigt werden. Eine detail-lierte Analyse zeigte, dass die PPI über alle Präpulsintensitäten hinweg sowohl mit den 2-back- als auch mit den 0-back-Bedingungen signifikant korrelierte, was auf eine Regulation durch konditionsübergreifende Prozesse (z. B. Aufmerksamkeit) schließen lässt. Wird jedoch die 0-back-Komponente aus den 2-back-Daten aus-partialisiert, sind spezifische und signifikante Korrelationen mit der Arbeitsgedächt-nisleistung für die 76 dB(A) PPI-Bedingung zu finden. Mit der vorliegenden Studie konnte die hohe Test-Retest-Reliabilität der PPI beim Menschen bestätigt und die Korrelation mit der Arbeitsgedächtnisleistung validiert und erweitert werden.
Whereas the lack of biomarkers in penile cancer (PeCa) impedes the development of efficacious treatment protocols, preliminary evidence suggests that c-MET and associated signaling elements may be dysregulated in this disorder. In the following study, we investigated whether c-MET and associated key molecular elements may have prognostic and therapeutic utility in PeCa. Formalin-fixed, paraffin-embedded tumor tissue from therapy-naïve patients with invasive PeCa was used for tissue microarray (TMA) analysis. Immunohistochemical staining was performed to determine the expression of the proteins c-MET, PPARg, β-catenin, snail, survivin, and n-MYC. In total, 94 PeCa patients with available tumor tissue were included. The median age was 64.9 years. High-grade tumors were present in 23.4%, and high-risk HPV was detected in 25.5%. The median follow-up was 32.5 months. High expression of snail was associated with HPV-positive tumors. Expression of β-catenin was inversely associated with grading. In both univariate COX regression analysis and the log-rank test, an increased expression of PPARg and c-MET was predictive of inferior disease-specific survival (DSS). Moreover, in multivariate analysis, a higher expression of c-MET was independently associated with worse DSS. Blocking c-MET with cabozantinib and tivantinib induced a significant decrease in viability in the primary PeCa cell line UKF-PeC3 isolated from the tumor tissue as well as in cisplatin- and osimertinib-resistant sublines. Strikingly, a higher sensitivity to tivantinib could be detected in the latter, pointing to the promising option of utilizing this agent in the second-line treatment setting.
The cellular composition of the tumor microenvironment, including tumor, immune, stromal, and endothelial cells, significantly influences responses to cancer therapies. In this study, we analyzed the impact of oxidative stress, induced by cold atmospheric plasma (CAP), on tumor cells, T cells, and macrophages, which comprise part of the melanoma microenvironment. To accomplish this, cells were grown in different in vitro cell culture models and were treated with varying amounts of CAP. Subsequent alterations in viability, proliferation, and phenotype were analyzed via flow cytometry and metabolic alterations by Seahorse Cell Mito Stress Tests. It was found that cells generally exhibited reduced viability and proliferation, stemming from CAP induced G2/M cell cycle arrest and subsequent apoptosis, as well as increased mitochondrial stress following CAP treatment. Overall, sensitivity to CAP treatment was found to be cell type dependent with T cells being the most affected. Interestingly, CAP influenced the polarization of M0 macrophages to a “M0/M2-like” phenotype, and M1 macrophages were found to display a heightened sensitivity to CAP induced mitochondrial stress. CAP also inhibited the growth and killed melanoma cells in 2D and 3D in vitro cell culture models in a dose-dependent manner. Improving our understanding of oxidative stress, mechanisms to manipulate it, and its implications for the tumor microenvironment may help in the discovery of new therapeutic targets.
In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and their ligands in the maladaptive remodeling of lung tissue, with special emphasis on idiopathic pulmonary fibrosis (IPF). Here we will focus on the pathways and cellular processes contributing to epithelial–mesenchymal miscommunication seen in this pathology. We will also provide an overview of the in vivo studies addressing the efficacy of different ErbB signaling inhibitors in experimental models of lung injury and highlight how such studies may contribute to our understanding of ErbB biology in the lung. Finally, we will discuss what we learned from clinical applications of the ErbB1 signaling inhibitors in cancer in order to advance clinical trials in IPF.
Children’s and adolescents’ lives drastically changed during COVID lockdowns worldwide. To compare accident- and injury-related admissions to pediatric intensive care units (PICU) during the first German COVID lockdown with previous years, we conducted a retrospective multicenter study among 37 PICUs (21.5% of German PICU capacities). A total of 1444 admissions after accidents or injuries during the first lockdown period and matched periods of 2017–2019 were reported and standardized morbidity ratios (SMR) were calculated. Total PICU admissions due to accidents/injuries declined from an average of 366 to 346 (SMR 0.95 (CI 0.85–1.05)). Admissions with trauma increased from 196 to 212 (1.07 (0.93–1.23). Traffic accidents and school/kindergarten accidents decreased (0.77 (0.57–1.02 and 0.26 (0.05–0.75)), whereas household and leisure accidents increased (1.33 (1.06–1.66) and 1.34 (1.06–1.67)). Less neurosurgeries and more visceral surgeries were performed (0.69 (0.38–1.16) and 2.09 (1.19–3.39)). Non-accidental non-suicidal injuries declined (0.73 (0.42–1.17)). Suicide attempts increased in adolescent boys (1.38 (0.51–3.02)), but decreased in adolescent girls (0.56 (0.32–0.79)). In summary, changed trauma mechanisms entailed different surgeries compared to previous years. We found no evidence for an increase in child abuse cases requiring intensive care. The increase in suicide attempts among boys demands investigation.