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In the framework of the relativistic quantum dynamics approach we investigate antiproton observables in Au-Au collisions at 10.7A GeV. The rapidity dependence of the in-plane directed transverse momentum p(y) of p's shows the opposite sigh of the nucleon flow, which has indeed recently been discovered at 10.7A GeV by the E877 group. The "antiflow" of p's is also predicted at 2A GeV and at 160 A GeV and appears at all energies also for pi's and K's. These predicted p anticorrelations are a direct proof of strong p annihilation in massive heavy ion reactions.
The quantum statistical model (QSM) is used to calculate nuclear fragment distributions in chemical equilibrium. Several observable isotopic effects are predicted for intermediate energy heavy ion collisions. It is demonstrated that particle ratios for different systemsdo not depend on the breakup density-the only free parameter in our model.The importance of entropy measurements is discussed. Specific particle ratios for the system Au-Au are predicted, which can be used to determine the chemical potentials of the hot midrapidity fragment source in nearly central heavy ion collisions. Pacs-Nr. 25.70 Pq
The Monte Carlo parton string model for multiparticle production in hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions at high energies is described. An adequate choice of the parameters in the model gives the possibility of recovering the main results of the dual parton model, with the advantage of treating both hadron and nuclear interactions on the same footing, reducing them to interactions between partons. Also the possibility of considering both soft and hard parton interactions is introduced.
The properties of pions from the hot and dense reaction stage of relativistic heavy ion collisions are investigated with the quantum molecular dynamics model. Pions originating from this reaction stage stem from resonance decay with enhanced mass. They carry high transverse momenta. The calculation shows a direct correlation between high pt pions, early freeze-out times and high freeze-out densities.
Dilepton spectra for p+p and p+d reactions at 4.9GeV are calculated. We consider electromagnetic bremsstrahlung also in inelastic reactions. N* and Delta* decay present the major contributions to the pho and omega meson yields.Pion annihilation yields only 1.5% of all pho's in p+d. The pho mass spectrum is strongly distorted due to phase space effects, populating dominantly dilepton masses below 770MeV.
We calculate thermal photon and neutral pion spectra in ultrarelativistic heavy-ion collisions in the framework of three-fluid hydrodynamics. Both spectra are quite sensitive to the equation of state used. In particular, within our model, recent data for S + Au at 200 AGeV can only be understood if a scenario with a phase transition (possibly to a quark-gluon plasma) is assumed. Results for Au+Au at 11 AGeV and Pb + Pb at 160 AGeV are also presented.
We predict the formation of highly dense baryon-rich resonance matter in Au+Au collisions at AGS energies. The final pion yields show observable signs for resonance matter. The Delta1232 resonance is predicted to be the dominant source for pions of small transverse momenta. Rescattering e ects consecutive excitation and deexcitation of Delta's lead to a long apparent life- time (> 10 fm/c) and rather large volumina (several 100 fm3) of the Delta-matter state. Heavier baryon resonances prove to be crucial for reaction dynamics and particle production at AGS.
Strong mean meson fields, which are known to exist in normal nuclei, experience a violent deformation in the course of a heavy-ion collision at relativistic energies. This may give rise to a new collective mechanism of the particle production, not reducible to the superposition of elementary nucleon-nucleon collisions.
We investigate the sensivity of pionic bounce-off and squeeze-out on the density and momentum dependence of the real part of the nucleon optical potential. For the in-plane pion bounce-off we find a strong sensivity on both the density and momentum dependence whereas the out-of-plane pion squeeze-out shows a strong sensivity only towards the momentum dependence but little sensivity towards the density dependence.
We demonstrate the importance of the Bose-statistical effects for pion production in relativistic heavy-ion collisions. The evolution of the pion phase-space density in central collisions of ultrarelativistic nuclei is studied in a simple kinetic model taking into account the effect of Bose-simulated pion production by the NN collisions in a dense cloud of mesons.
Triple differential cross sections of pions in heavy ion collisions at 1 GeV/nucl. are studied with the IQMD model. After discussing general properties of resonance and pion production we focus on azimuthal correlations: At projectile- and target-rapidities we observe an anticorrelation in the in-plane transverse momentum between pions and protons. At c.m.-rapidity, however, we find that high pt pions are being preferentially emitted perpendicular to the event-plane. We investigate the causes of those correlations and their sensitivity on the density and momentum dependence of the real and imaginary part of the nucleon and pion optical potential.
The rapidity distribution of thermal photons produced in Pb+Pb collisions at CERN-SPS energies is calculated within scaling and three- fluid hydrodynamics. It is shown that these scenarios lead to very different rapidity spectra. A measurement of the rapidity dependence of photon radiation can give cleaner insight into the reaction dynamics than pion spectra, especially into the rapidity dependence of the temperature.
This thesis examines the spread and promotion of English on a global level, from a historical perspective in particular ‘Third World’ contexts. The globalization of English as an exclusive language of power is considered to be a trap, when accompanied by an ideology aiming to universalize monolingual and monocultural norms and standards. World-wide English diffusion is related - not to any mystical effects of some psycho-social mechanisms or transmuting alchemy - but to a global rise of military, political, economic, communicational and cultural Euro-American hegemony. The fact that the English language has become perhaps the primary medium of social control and power has not been given a prominent place in the analyses of established social scientists or political planners. On the contrary, the positively idealized dominance of English as a universal medium has become part of a collection of myths seeking to deny the global reality of multilingualism. Not allowing for the existence of any power besides itself, the perpetuation of this hegemony of English within a multilingual scenario has become a contradiction in terms. Centuries of colonialism, followed by neo-colonialism, are seen to have resulted in a world-wide consensus favouring centralization and homogenization of state and world economies, administrations, language, education and mass media systems, as prerequisites to local and global unity. The particular case of India as encountered by a colonizing Britain is used to illustrate the historical clash between differing language and educational traditions and cultures. It was on the strength of their own predominantly positive attitudes towards diversity - encoded in their promotion of complex social and religious philosophies, as well as varied economic and educational practices of pluralism and hierarchy-without-imposition, unity in diversity, etc. - that the people and their leaders finally achieved Indian independence from British colonialism. Contemporary Indian society, however, is still grappling with the legacy of a Eurocentric civilizational model - encoded in the neo-colonial system of English education - and in conflict with its own positively idealized and actively promoted traditions of pluralism. On national and international levels, the destabilization and destruction of diversity continues to threaten more than the linguistic and cultural uniqueness of numerous communities and individuals. For those majorities and minorities who refuse to give up their ‘differences’, political, economic and physical survival is at stake. A paradoxical reality, seldom acknowledged, is that while for the politically and economically already powerful language groups, the enormous resources spent on formal (language) education have become a means to maintain their material and political capital, whereas for the majority of modern societies' marginalized members, powerful linguistic barriers to full economic or political participation remain firmly in place. The justifications for perpetuating exclusionary policies and sustaining structural inequality have come from monocultural ideological assumptions in education and language policies as one of the key mechanisms for state control of labour. This thesis concludes that the trap of an ideologically exclusive status for English can be avoided by theoretically positivizing and institutionally promoting existing multilingual and multicultural peoples’ realities as an integral part of their human rights, in order to resist global Englishization.
Spectra of various particle species have been calculated with the Quantum Molecular Dynamics (QMD) model for very central collisions of Au+Au. They are compatible with the idea of a fully stopped thermal source which exhibits a transversal expansion besides the thermal distribution of an ideal gas. How- ever, the microscopic analyses of the local flow velocities and temperatures indicate much lower temperatures at densities associated with the freeze-out. The results express the overall impossibility of a model-independent determi- nation of nuclear temperatures from heavy ion spectral data, also at other energies (e.g. CERN) or for other species (i.e. pions, kaons, hyperons)
In the framework of RQMD we investigate antiproton observables in massive heavy ion collisions at AGS energies and compare to preliminary results of the E878 collaboration. We focus here on the considerable influence of the real part of an antinucleon nucleus optical potential on the ¯p momentum spectra. Pacs-numbers: 14.20 Dh, 25.70.-z
In the framework of the relativistic quantum molecular dynamics approach (RQMD) we investigate antideuteron (d) observables in Au+Au collisions at 10.7 AGeV. The impact parameter dependence of the formation ratios d/p2 and d/p2 is calculated. In central collisions, the antideuteron formation ratio is predicted to be two orders of magnitude lower than the deuteron formation ratio. The d yield in central Au+Au collisions is one order of magnitude lower than in Si+Al collisions. In semicentral collisions di erent configuration space distributions of p s and d s lead to a large squeeze out e ect for antideuterons, which is not predicted for the p s.
Different numerical approaches and algorithms arising in the context of modelling of cellular tissue evolution are discussed in this thesis. Being suited in particular to off-lattice agent-based models, the numerical tool of three-dimensional weighted kinetic and dynamic Delaunay triangulations is introduced and discussed for its applicability to adjacency detection. As there exists no implementation of a code that incorporates all necessary features for tissue modelling, algorithms for incremental insertion or deletion of points in Delaunay triangulations and the restoration of the Delaunay property for triangulations of moving point sets are introduced. In addition, the numerical solution of reaction-diffusion equations and their connection to agent-based cell tissue simulations is discussed. In order to demonstrate the applicability of the numerical algorithms, biological problems are studied for different model systems: For multicellular tumour spheroids, the weighted Delaunay triangulation provides a great advantage for adjacency detection, but due to the large cell numbers the model used for the cell-cell interaction has to be simplified to allow for a numerical solution. The agent-based model reproduces macroscopic experimental signatures, but some parameters cannot be fixed with the data available. A much simpler, but in key properties analogous, continuum model based on reaction-diffusion equations is likewise capable of reproducing the experimental data. Both modelling approaches make differing predictions on non-quantified experimental signatures. In the case of the epidermis, a smaller system is considered which enables a more complete treatment of the equations of motion. In particular, a control mechanism of cell proliferation is analysed. Simple assumptions suffice to explain the flow equilibrium observed in the epidermis. In addition, the effect of adhesion on the survival chances of cancerous cells is studied. For some regions in parameter space, stochastic effects may completely alter the outcome. The findings stress the need of establishing a defined experimental model to fix the unknown model parameters and to rule out further models.
Flight paths of homing pigeons were measured with a newly developed recorder based on GPS. The device consists of a GPS receiver board, a logging facility, an antenna, a power supply, a DCDC converter and a casing. It has a weight of 33g and works reliably with a sampling rate of 1/s with an operation time of about 3 h, providing timeindexed data on geographic positions, ground speed and altitude. The data are downloaded when the bird is recaptured. The devices are fixed to the birds with a harness. The measured complete flight paths show many details: e.g. initial loops flown immediately after release and large detours flown by some pigeons. We are here presenting 3 examples of flight paths from a release site 17.3 km Northeast of the home loft in Frankfurt. Mean speed in flight, duration of breaks and length of the flight path were calculated. The pigeons chose different routes and have different individual tendencies to fly loops over the village close to the release site.
This paper describes a first version of the GPS flight recorder for homing pigeons. The GPS recorder consists of a hybrid GPS board, a patch antenna 19*19 mm, a 3 V Lithium battery as power supply, a DCDC converter, a logging facility and an additional microprocessor. It has a weight of 33g. Prototypes were tested and worked reliably with a sampling rate of 1/sec and with an operation time of about 3 h. In first tests on homing pigeons 9 flight paths were recorded, showing details like loops flown immediately after the release, complete routes over 30 km including detours, rest periods and speed.
We calculate the evolution of quark-gluon-plasma droplets during the hadronization in a thermodynamical model. It is speculated that cooling as well as strangeness enrichment allow for the formation of strangelets even at very high initial entropy per baryon S/Ainit H 500 and low initial baryon numbers of Ainit B H 30. It is shown that the droplet with vanishing initial chemical potential of strange quarks and a very moderate chemical potential of up/down quarks immediately charges up with strangeness. Baryon densi- ties of H 2 0 and strange chemical potentials of µs > 350 MeV are reached if strangelets are stable. The importance of net baryon and net strangeness fluctuations for the possible strangelet formation at RHIC and LHC is em- phasized. Pacs-Classif.: 25.15.tr, 12.38.Mh, 24.85.tp
The extension of the Periodic System into hitherto unexplored domains - anti- matter and hypermatter - is discussed. Starting from an analysis of hyperon and single hypernuclear properties we investigate the structure of multi-hyperon objects (MEMOs) using an extended relativistic meson field theory. These are contrasted with multi-strange quark states (strangelets). Their production mechanism is stud- ied for relativistic collisions of heavy ions from present day experiments at AGS and SPS to future opportunities at RHIC and LHC. It is pointed out that abso- lutely stable hypermatter is unlikely to be produced in heavy ion collisions. New attention should be focused on short lived metastable hyperclusters ( / 10 10s) and on intensity interferometry of multi-strange-baryon correlations.
We demonstrate that the creation of strange matter is conceivable in the midrapidity region of heavy ion collisions at Brookhaven RHIC and CERN LHC. A finite net-baryon density, abundant (anti)strangeness production, as well as strong net-baryon and net-strangeness fluctuations, provide suitable initial conditions for the formation of strangelets or metastable exotic multistrange ( baryonic) objects. Even at very high initial entropy per baryon SyAinit ¯ 500 and low initial baryon numbers of Ainit B ¯ 30 a quark-gluon-plasma droplet can immediately charge up with strangeness and accumulate net-baryon number. PACS numbers: 25.75.Dw, 12.38.Mh, 24.85.+
Abstract: An accurate impact parameter determination in a heavy ion collision is crucial for almost all further analysis. The capabilities of an artificial neural network are investigated to that respect. A novel input generation for the network is proposed, namely the transverse and longitudinal momentum distribution of all outgoing (or actually detectable) particles. The neural network approach yields an improvement in performance of a factor of two as compared to classical techniques. To achieve this improvement simple network architectures and a 5 × 5 input grid in (pt, pz) space are suffcient.
We want to draw the attention to the dynamics of a (finite) hadronizing quark matter drop. Strange and antistrange quarks do not hadronize at the same time for a baryon-rich system1. Both the hadronic and the quark matter phases enter the strange sector fs 6= 0 of the phase diagram almost immediately, which has up to now been neglected in almost all calculations of the time evolution of the system. Therefore it seems questionable, whether final particle yields reflect the actual thermodynamic properties of the system at a certain stage of the evolution. We put special interest on the possible formation of exotic states, namely strangelets (multistrange quark clusters). They may exist as (meta-)stable exotic isomers of nuclear matter 2. It was speculated that strange matter might exist also as metastable exotic multi-strange (baryonic) objects (MEMO s 3). The possible creation in heavy ion collisions of long-lived remnants of the quark-gluon-plasma, cooled and charged up with strangeness by the emission of pions and kaons, was proposed in 1,4,5. Strangelets can serve as signatures for the creation of a quark gluon plasma. Currently, both at the BNL-AGS and at the CERN-SPS experiments are carried out to search for MEMO s and strangelets, e. g. by the E864, E878 and the NA52 collaborations9,
The microscopic phasespace approach URQMD is used to investigate the stopping power and particle production in heavy systems at SPS and RHIC energies. We find no gap in the baryon rapidity distribution even at RHIC. For CERN energies URQMD shows a pile up of baryons and a supression of multi-nucleon clusters at midrapidity.
Location-based services (LBS) are services that position your mobile phone to provide some context-based service for you. Some of these services – called ‘location tracking’ applications - need frequent updates of the current position to decide whether a service should be initiated. Thus, internet-based systems will continuously collect and process the location in relationship to a personal context of an identified customer. This paper will present the concept of location as part of a person’s identity. I will conceptualize location in information systems and relate it to concepts like privacy, geographical information systems and surveillance. The talk will present how the knowledge of a person's private life and identity can be enhanced with data mining technologies on location profiles and movement patterns. Finally, some first concepts about protecting location information.
Mobile telephony and mobile internet are driving a new application paradigm: location-based services (LBS). Based on a person’s location and context, personalized applications can be deployed. Thus, internet-based systems will continuously collect and process the location in relationship to a personal context of an identified customer. One of the challenges in designing LBS infrastructures is the concurrent design for economic infrastructures and the preservation of privacy of the subjects whose location is tracked. This presentation will explain typical LBS scenarios, the resulting new privacy challenges and user requirements and raises economic questions about privacy-design. The topics will be connected to “mobile identity” to derive what particular identity management issues can be found in LBS.
The stopping behaviour of baryons in massive heavy ion collisions ( s k 10AGeV) is investigated within di erent microscopic models. At SPS-energies the predictions range from full stopping to virtually total transparency. Experimental data are indicating strong stopping. The initial baryo-chemical potentials and temperatures at collider energies and their impact on the formation probability of strange baryon clusters and strangelets are discussed.
Nuclear clusters as a probe for expansion flow in heavy ion reactions at 10-A/GeV - 15-A/GeV.
(1996)
A phase space coalescence description based on the Wigner-function method for cluster formation in relativistic nucleus-nucleus collisions is presented. The momentum distributions of nuclear clusters d,t and He are predicted for central Au(11.6AGeV)Au and Si(14.6AGeV)Si reactions in the framework of the RQMD transport approach. Transverse expansion leads to a strong shoulderarm shape and di erent inverse slope parameters in the transverse spectra of nuclear clusters deviating markedly from thermal distributions. A clear bounce-o event shape is seen: the averaged transverse flow velocities in the reaction plane are for clusters larger than for protons. The cluster yields particularly at low pt at midrapidities and the in-plane (anti)flow of clusters and pions change if suitably strong baryon potential interactions are included. This allows to study the transient pressure at high density via the event shape analysis of nucleons, nucleon clusters and other hadrons.
We investigate the properties of di erent modifications to the linear -model (including a dilaton field associated with broken scale invariance) at finite baryon density and nonzero temperature T. The explicit breaking of chiral symmetry and the way the vector meson mass is generated are significant for the appearance of a phase of nearly vanishing nucleon mass besides the solution describing normal nuclear matter. The elimination of the abnormal solution prohibits the onset of a chiral phase transition but allows to lower the compressibility to a reasonable range. The repulsive contributions from the vector mesons are responsible for the wide range of stability of the normal phase in the (µ, T)-plane. The abnormal solution becomes not only energet- ically preferable to the normal state at high temperature or density, but also mechanically stable due to the inclusion of dilatons. PACS number:12.39.F
We discuss the properties of two distinct forms of hypothetical strange matter, small lumps of strange quark matter (strangelets) and of hyperon matter (metastable exotic multihypernuclear objects: MEMOs), with special empha- sis on their relevance for present and future heavy ion experiments. The masses of small strangelets up to AB = 40 are calculated using the MIT bag model with shell mode filling for various bag parameters. The strangelets are checked for possible strong and weak hadronic decays, also taking into account multiple hadron decays. It is found that strangelets which are stable against strong decay are most likely highly negative charged, contrary to previous findings. Strangelets can be stable against weak hadronic decay but their masses and charges are still rather high. This has serious impact on the present high sensitivity searches in heavy ion experiments at the AGS and CERN facilities. On the other hand, highly charged MEMOs are predicted on the basis of an extended relativistic mean field model. Those objects could be detected in future experiments searching for short lived, rare composites. It is demonstrated that future experiments can be sensitive to a much wider variety of strangelets.
According to the Walecka mean field theory of nuclear interaction the collective mutual deceleration of the colliding nuclei gives rise to the bremsstrahlung of real and virtual ! mesons. It is shown that decays of these mesons may give a noticeable contribution to the observed yields of the baryon antibaryon pairs, dileptons and pions. Excitation functions and rapidity distributions of particles produced by this mechanism are calculated under some simplifying assumptions about the space time variation of meson fields in nuclear collisions. The calculated multiplicities of coherently produced particles grow fast with the bombarding energy, reaching a saturation above the RHIC bombarding energy. In the case of central Au+Au collisions the bremsstrahlung mechanism becomes comparable with particle production in incoherent hadron hadron collisions above the AGS energies. The rapidity spectra of antibaryons and pions exhibit a characteristic two hump structure which is a consequence of incomplete projectile target stopping at the initial stage of the reaction. The predicted distribution of e+e pairs has a strong peak at invariant masses Me+e < 0.5 GeV.
Measured hadron yields from relativistic nuclear collisions can be equally well understood in two physically distinct models, namely a static thermal hadronic source versus a time-dependent, non-equilibrium hadronization off a quark gluon plasma droplet. Due to the time-dependent particle evaporation off the hadronic surface in the latter approach the hadron ratios change (by factors of / 5) in time. The overall particle yields then reflect time averages over the actual thermodynamic properties of the system at a certain stage of evolution.
We study the time scale for pressure equilibration in heavy ion collisions at AGS energies within the three-fluid hydrodynamical model and a microscopic cascade model (UrQMD). We find that kinetic equilibrium is reached in both models after a time of 5 fm/c (center-of-mass time). Thus, observables which are sensitive to the early stage of the reaction differ considerably from the expectations within the instant thermalization scenario (one-fluid hydrodynamical model).
In this paper, I examine the potential of mobile alerting services empowering investors to react quickly to critical market events. Therefore, an analysis of short-term (intraday) price effects is performed. I find abnormal returns to company announcements which are completed within a timeframe of minutes. To make use of these findings, these price effects are predicted using pre-defined external metrics and different estimation methodologies. Compared to previous research, the results provide support that artificial neural networks and multiple linear regression are good estimation models for forecasting price effects also on an intraday basis. As most of the price effect magnitude and effect delay can be estimated correctly, it is demonstrated how a suitable mobile alerting service combining a low level of user-intrusiveness and timely information supply can be designed.
Basic problems of the semiclassical microscopic modelling of strongly interacting systems are discussed within the framework of Quantum Molecular Dynamics (QMD). This model allows to study the influence of several types of nucleonic interactions on a large variety of observables and phenomena occur- ring in heavy ion collisions at relativistic energies. It is shown that the same predictions can be obtained with several numerically completely di erent and independently written programs as far as the same model parameters are employed and the same basic approximations are made. Many observ- ables are robust against variations of the details of the model assumptions used. Some of the physical results, however, depend also on rather technical parameters like the preparation of the initial configuration in phase space. This crucial problem is connected with the description of the ground state of single nuclei, which di ers among the various approaches. An outlook to an improved molecular dynamics scheme for heavy ion collisions is given.
Abstract: We study transverse expansion and directed flow in Au(11AGeV)Au reactions within a multi-fluid dynamical model. Although we do not employ an equation of state (EoS) with a first order phase transition, we find a slow increase of the transverse velocities of the nucleons with time. A similar behaviour can be observed for the directed nucleon flow. This is due to non-equilibrium e ects which also lead to less and slower conversion of longitudinal into transverse momentum. We also show that the proton rapidity distribution at CERN energies, as calculated within this model, agrees well with the preliminary NA44-data.
To describe ultrarelativistic heavy-ion collisions we construct a three-fluid hydrodynamical model. In contrast to one-fluid hydrodynamics, it accounts for the finite stopping power of nuclear matter, i.e. for nonequilibrium e ects in the early stage of the reaction. Within this model, we study baryon dynamics in the BNL-AGS energy range. For the system Au+Au we find that kinetic equilibrium between projectile and target nucleons is established only after a time teq CM H 5 fm/c C 2RAu/³CM. Observables which are sensitive to the early stage of the collision (like e.g. nucleon flow) therefore di er considerably from those calculated in the one-fluid model.
We examine the properties of both forms of strange matter, small lumps of strange quark matter (strangelets) and of strange hadronic matter (Metastable Exotic Multihypernuclear Objects: MEMOs) and their relevance for present and future heavy ion searches. The strong and weak decays are discussed separately to distinguish between long-lived and short-lived candidates where the former ones are detectable in present heavy ion experiments while the latter ones in future heavy ion experiments, respectively. We find some long-lived strangelet candidates which are highly negatively charged with a mass to charge ratio like a anti deuteron (M/Z 2) but masses of A=10 to 16. We predict also many short-lived candidates, both in quark and in hadronic form, which can be highly charged. Purely hyperonic nuclei like the (2 02 ) are bound and have a negative charge while carrying a positive baryon number. We demonstrate also that multiply charmed exotics (charmlets) might be bound and can be produced at future heavy ion colliders.
My graduate thesis is on the "Structural studies of membrane transport proteins". Transporters are membrane proteins that have multiple membrane-spanning a-helices. They are dynamic and diverse proteins, undergoing a large conformational change and transporting wide range of susbtrates. Based on their energy source they can be classified into primary and secondary transport systems. Primary transport systems are driven by the use of chemical (ATP) or light energy, while secondary transporters utilize ion gradients to transport substrates. I began my PhD dissertation on secondary transporters by two-dimensional crystallization and electron crystallographic analysis and recently my focus also has shifted towards 3D crystallization. The following projects constitute my PhD thesis: 1) 2D crystallization of MjNhaP1 and pH induced structural change: MjNhaP1, a Na+/H+ antiporter that is regulated by pH has been implicated in homeostasis of H+ and Na+ in Methanococcus jannaschii, a hyperthermophilic archaeon that grows optimally at 85°C. MjNhaP1 was cloned and expressed in E. coli. Two-dimensional crystals were obtained from purified protein at pH4. Electron cryo-microscopy yielded an 8Å projection map. The map of MjNhaP1 shows elongated densities in the centre of the dimer and a cluster of density peaks on either side of the dimer core, indicative of a bundle of 4-6 membrane-spanning helices. The effect of pH on the structure of MjNhaP1was studied in situ in 2D crystals revealing a major change in density within the helix bundle relative to the dimer interface. This change occurred at pH6 and above. The two conformations at low and high pH most likely represent the closed and open states of the antiporter, respectively. This is the first instance where a conformational change associated with the regulation of a secondary transporter appears to map structurally. Reconstruction of 3D map and high-resolution structure by x-ray crystallography would be necessary to understand the mechanism of ion transport and regulation by pH. 2) 2D crystallization of Proline transporter: Proline transporter (PutP) from E.coli belongs the sodium-solute symporter family that includes disease related sodium dependent glucose and iodide transporter in humans. Sodium and proline are co-transported with a stoichiometry of 1:1. Purified PutP was reconstituted to yield 2D crystals that were hexagonal in nature. The 2D crystals had tendency to stack indicating their willingness to form 3D crystals. A projection map of PutP from negatively stained crystals showed trimeric arrangement of protein. Other members of the SSF family have been shown to be monomers. My analysis of oligomeric state of PutP in detergent by blue native gel indicates a monomer in detergent solution. It is likely that PutP can function as a monomer but at higher concentration and in lipid bilayer it tends to form trimer. 3) Oligomeric state and crystallization of carnitine transporter from E.coli: E.coli carnitine transporter (CaiT) belongs to the BCCT (Betaine, Carnitine and Choline) superfamily that transports molecules with quaternary amine groups. CaiT is predicted to span the membrane 12 times and acts as a L-carnitine/g-butyrobetaine exchanger. Unlike other members in this transporter family, it does not require an ion gradient and does not respond to osmotic stress. Over-expression of the protein yielded ~2mg of protein/L of culture. The structure and oligomeric state of the protein were analyzed in detergent and lipid bilayers. Blue native gel electrophoresis indicated that CaiT was a trimer in detergent solution. Gel filtration and cross-linking studies further support this. Reconstitution of CaiT into lipid bilayers resulted in 2D crystals. Analysis of negatively stained 2D crystals confirmed that CaiT is a trimer in the membrane. Initial 3D crystallization trials have been successful and currently, the crystals diffract to 6Å and are being improved. 4) Monomeric porin OmpG: OmpG is a bacterial outer membrane b-barrel protein. It is monomeric and its size (33kDa) places it as a prime candidate for a structural solution, using the recently developed method of solid state NMR (work in collaboration with Prof.Hartmut Oskinat, FMP, Berlin). A long-term aim would be to study porins as templates for designing nanopores, for DNA sequencing and identification. I have expressed OmpG in inclusion bodies and refolded at an efficiency of >90% into a functional form using detergent. OmpG was then crystallized by 2D crystallization yielding an 8Å projection map whose structure was similar to native protein. In addition, these crystals were used for structure determination by solid state NMR. An initial spectrum of heavy isotopically labeled OmpG has allowed identification of specific amino acid residues including threonine and proline. Additionally, I obtained 3D crystals in detergent that diffract to 5.5Å and are being improved.
Measured hadron yields from relativistic nuclear collisions can be equally well understood in two physically distinct models, namely a static thermal hadronic source vs. a time-dependent, nonequilibrium hadronization o a quark-gluon plasma droplet. Due to the time-dependent particle evapora- tion o the hadronic surface in the latter approach the hadron ratios change (by factors of <H 5) in time. Final particle yields reflect time averages over the actual thermodynamic properties of the system at a certain stage of the evolution. Calculated hadron, strangelet and (anti-)cluster yields as well as freeze-out times are presented for di erent systems. Due to strangeness distillation the system moves rapidly out of the T, µq plane into the µs-sector. Classif.: 25.75.Dw, 12.38.Mh, 24.85.+p
We discuss the early evolution of ultrarelativistic heavy-ion collisions within a multi- fluid dynamical model. In particular, we show that due to the finite mean-free path of the particles compression shock waves are smeared out considerably as compared to the one-fluid limit. Also, the maximal energy density of the baryons is much lower. We discuss the time scale of kinetic equilibration of the baryons in the central region and its relevance for directed flow. Finally, thermal emission of direct photons from the fluid of produced particles is calculated within the three-fluid model and two other simple expansion models. It is shown that the transverse momentum and rapidity spectra of photons give clue to the cooling law and the early rapidity distribution of the photon source.
Hadron and hadron cluster production in a hydrodynamical model including particle evaporation
(1997)
We discuss the evolution of the mixed phase at RHIC and SPS within boostinvariant hydrodynamics. In addition to the hydrodynamical expansion, we also consider evaporation of particles o the surface of the fluid. The back-reaction of this evaporation process on the dynamics of the fluid shortens the lifetime of the mixed phase. In our model this lifetime of the mixed phase is d 12 fm/c in Au + Au at RHIC and d 6.5 fm/c in Pb + Pb at SPS, even in the limit of vanishing transverse expansion velocity. Strong separation of strangeness occurs, especially in events (or at rapidities) with relatively high initial net baryon and strangeness number, enhancing the multiplicity of MEMOs (multiply strange nuclear clusters). If antiquarks and antibaryons reach saturation in the course of the pure QGP or mixed phase, we find that at RHIC the ratio of antideuterons to deuterons may exceed 0.3 and even 4He/4He > 0.1. In S + Au at SPS we find only N/N H 0.1. Due to fluctuations, at RHIC even negative baryon number at midrapidity is possible in individual events, so that the antibaryon and antibaryon-cluster yields exceed those of the corresponding baryons and clusters.
Protein-protein interactions within the plane of cellular membranes play a key role for many biological processes and in particular for transmembrane signaling. A prominent example is the ligand-induced crosslinking of cytokine receptors, where 3- dimensional cytokine binding followed by 2-dimensional interaction between the receptor subunits have been recognized to be important for regulating signaling specificity. The fundamental importance of such coupled interactions for cell-surface receptor activation has stimulated numerous theoretical studies, which have hardly been confirmed experimentally. An experimental approach to measure interactions and real time kinetics of type I interferon (IFN) induced assembly between interferon receptor subunits ifnar2 and ifnar1 on membrane was developed and determinants of the 2-dimensional interactions, such as dimensionality, size, valency, orientation, membrane fluidity and receptor density were quantitatively addressed The C-terminal decahistidine tagged extracellular domains (EC) of ifnar1 and ifnar2 were site- specifically tethered onto solid-supported fluid lipid membrane, which carried covalently attached chelator bis-nitrilotriacetic acid (bis-NTA) groups. Interactions on the lipid bilayer were detected with a novel solid phase detection technique, which allows simultaneous detection of ligand binding to a membrane anchored receptors and lateral interaction between them in the real time. This was achieved by combining two optical techniques: label-free reflectance interferometry (RIf) and total internal reflection fluorescence spectroscopy (TIRFS). Fluorescence signals, in the order of 10 fluorophores/µm2, were detected without substantial photobleaching. The sensitivity of the label-free interferometric detection was in the range of 10 pg/mm2. The crosstalk between the two signals was eliminated by means of spectral separation. Fluorescence was detected in the visible region and RIf was performed at 800 nm in the near infrared. Flow through conditions allowed to automate experiments and measure binding events as fast as ~ 5 s-1. Using this technique we have dissected the interactions involved in IFN-induced ifnar crosslinking. 2-dimensional association and dissociation rate constants were independently determined by tethering high stoichiometric excess of one of the receptor subunits and comparing dissociation of the labelled ligand away from the membrane in the absence and presence of the non-labelled high affinity competitor. Dissociation traces were fitted with the two-step dissociation model: the first step being the 2-dimensional separation of the ternary complex followed by the 3- dimensional ligand dissociation into solution. Label-free RIf detection allowed absolute parameterization of the 2-dimensional concentrations of the ifnar subunits on the membrane. The TIRFS signal provided high sensitivity of the ligand dissociation and was correlated against the RIf signal before fitting. These features of the detection system allowed us to parameterize the model, and the 2-dimensional association or dissociation rate constants were the only variables during the fitting. Another FRET based binding assay was developed to determine the 2- dimensional dissociation rate constant using a pulse-chase approach. The donor fluorescence from ifnar2-EC was quenched upon the ternary complex formation with the acceptor-labelled IFN and the nonlabelled ifnar1-EC. The equilibrium was perturbed by rapid tethering of substantial excess of the nonlabelled ifnar2-EC onto the membrane. The exchange of the labelled ifnar2-EC with the nonlabelled one was monitored as the decrease in the FRET signal with the 2-dimensional dissociation of ifnar2-EC from the ternary complex being the rate limiting step. Based on the several mutants and variants of the interacting proteins, the effect of different rate constants and receptor orientation on the 2-dimensional crosslinking dynamics was studied. We have identified several critical features of the 2- dimensional interactions on membranes, which cannot be readily concluded from the solution binding assays. The restricted rotation and the increased lifetime of the encounter complex due to high membrane viscosity are the main determinants of the 2-dimensional association. Tethering ifnar1-EC to the membrane via N-terminal decahistidine tag decreased the 2-dimensional association rate constant 4-5 fold. Electrostatic attraction and steering, the important mechanism to enhance association rate constant between the soluble proteins, are not pronounced for interactions on the membrane. Protein orientation due to membrane anchoring dominates over electrostatic effects and together with the increased lifetime of the encounter complex consequence that 2-dimensional association rate constants are quite similar and do not correlate with association rate constants in solution. The 2- dimensional dissociation rate constants were generally 2-5-fold lower compared to the corresponding 3-dimensional dissociation rate constants in solution. Possible explanations for this are that long lifetime of the encounter complex stabilizes the ternary complex or that membrane tethering affects the interaction diagram. In conclusion, combined TIRFS-RIf detection turn to be powerful and versatile technique to characterize protein-protein interactions on membranes.
Multiplayer games have become very popular in the PC market. Almost none of the current games are shipped without some support for multiplayer gaming. At the same time mobile devices are becoming more powerful and popularity of games on these platforms increases. However, there are almost no games that support multiplayer gaming despite the multiple options of these devices to connect with each other and build mobile ad hoc networks. Reasons for this lack of multiplayer support are the high diversity of mobile devices as well as the different protocols and their properties that these devices support. With “SmartBlaster” we developed a multiplayer game for several different platforms that is using several different channels (Bluetooth, IrDa, 802.11 and other networks supporting TCP/IP) to communicate between them.