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The cosmological implications of the Covariant Canonical Gauge Theory of Gravity (CCGG) are investigated. CCGG is a Palatini theory derived from first principles using the canonical transformation formalism in the covariant Hamiltonian formulation. The Einstein-Hilbert theory is thereby extended by a quadratic Riemann-Cartan term in the Lagrangian. Moreover, the requirement of covariant conservation of the stress-energy tensor leads to necessary presence of torsion. In the Friedman universe that promotes the cosmological constant to a time-dependent function, and gives rise to a geometrical correction with the EOS of dark radiation. The resulting cosmology, compatible with the ΛCDM parameter set, encompasses bounce and bang scenarios with graceful exits into the late dark energy era. Testing those scenarios against low-z observations shows that CCGG is a viable theory.
The cosmological implications of the Covariant Canonical Gauge Theory of Gravity (CCGG) are investigated. CCGG is a Palatini theory derived from first principles using the canonical transformation formalism in the covariant Hamiltonian formulation. The Einstein-Hilbert theory is thereby extended by a quadratic Riemann-Cartan term in the Lagrangian. Moreover, the requirement of covariant conservation of the stress-energy tensor leads to necessary presence of torsion. In the Friedman universe that promotes the cosmological constant to a time-dependent function, and gives rise to a geometrical correction with the EOS of dark radiation. The resulting cosmology, compatible with the ΛCDM parameter set, encompasses bounce and bang scenarios with graceful exits into the late dark energy era. Testing those scenarios against low-z observations shows that CCGG is a viable theory.
Aim: Replicate the analysis conducted by Prof. Dr. Alexander W. Schmidt-Catran (Goethe University Frankfurt), Prof. Dr. Malcolm Fairbrother (Umea University), and Prof. Dr. Hans-Jürgen Andreß (University of Cologne) that was published in a special issue on Cross-National Comparative Research in the German academic journal Kölner Zeitschrift für Soziologie und Sozialpsychologie in 2019. Result: Almost all calculations, tables and graphs from Schmidt-Catran et al. (2019) could be replicated sufficiently well in R.
MicroRNAs (miRNAs) are critical post-transcriptional regulators in many biological processes. They act by guiding RNA-induced silencing complexes to miRNA response elements (MREs) in target mRNAs, inducing translational inhibition and/or mRNA degradation. Functional MREs are expected to predominantly occur in the 3' untranslated region and involve perfect base-pairing of the miRNA seed. Here, we generate a high-resolution map of miR-181a/b-1 (miR-181) MREs to define the targeting rules of miR-181 in developing murine T-cells. By combining a multi-omics approach with computational high-resolution analyses, we uncover novel miR-181 targets and demonstrate that miR-181 acts predominantly through RNA destabilization. Importantly, we discover an alternative seed match and identify a distinct set of targets with repeat elements in the coding sequence which are targeted by miR-181 and mediate translational inhibition. In conclusion, deep profiling of MREs in primary cells is critical to expand physiologically relevant targetomes and establish context-dependent miRNA targeting rules.
MicroRNAs (miRNAs) are critical post-transcriptional regulators in many biological processes. They act by guiding RNA-induced silencing complexes to miRNA response elements (MREs) in target mRNAs, inducing translational inhibition and/or mRNA degradation. Functional MREs are expected to predominantly occur in the 3’ untranslated region and involve perfect base-pairing of the miRNA seed. Here, we generate a high-resolution map of miR-181a/b-1 (miR-181) MREs to define the targeting rules of miR-181 in developing murine T-cells. By combining a multi-omics approach with computational high-resolution analyses, we uncover novel miR-181 targets and demonstrate that miR-181 acts predominantly through RNA destabilization. Importantly, we discover an alternative seed match and identify a distinct set of targets with repeat elements in the coding sequence which are targeted by miR-181 and mediate translational inhibition. In conclusion, deep profiling of MREs in primary cells is critical to expand physiologically relevant targetomes and establish context-dependent miRNA targeting rules.
Key Points:
* Deep profiling identifies novel targets of miR-181 associated with global gene regulation.
* miR-181 MREs in repeat elements in the coding sequence act through translational inhibition.
* High-resolution analysis reveals an alternative seed match in functional MREs.
MicroRNAs (miRNAs) are critical post-transcriptional regulators in many biological processes. They act by guiding RNA-induced silencing complexes to miRNA response elements (MREs) in target mRNAs, inducing translational inhibition and/or mRNA degradation. Functional MREs are expected to predominantly occur in the 3' untranslated region and involve perfect base-pairing of the miRNA seed. Here, we generate a high-resolution map of miR-181a/b-1 (miR-181) MREs to define the targeting rules of miR-181 in developing murine T-cells. By combining a multi-omics approach with computational high-resolution analyses, we uncover novel miR-181 targets and demonstrate that miR-181 acts predominantly through RNA destabilization. Importantly, we discover an alternative seed match and identify a distinct set of targets with repeat elements in the coding sequence which are targeted by miR-181 and mediate translational inhibition. In conclusion, deep profiling of MREs in primary cells is critical to expand physiologically relevant targetomes and establish context-dependent miRNA targeting rules.
In this paper, we investigate the usefulness of a wide range of features for their usefulness in the resolution of nominal coreference, both as hard constraints (i.e. completely removing elements from the list of possible candidates) as well as soft constraints (where a cumulation of violations of soft constraints will make it less likely that a candidate is chosen as the antecedent). We present a state of the art system based on such constraints and weights estimated with a maximum entropy model, using lexical information to resolve cases of coreferent bridging.
When a statistical parser is trained on one treebank, one usually tests it on another portion of the same treebank, partly due to the fact that a comparable annotation format is needed for testing. But the user of a parser may not be interested in parsing sentences from the same newspaper all over, or even wants syntactic annotations for a slightly different text type. Gildea (2001) for instance found that a parser trained on the WSJ portion of the Penn Treebank performs less well on the Brown corpus (the subset that is available in the PTB bracketing format) than a parser that has been trained only on the Brown corpus, although the latter one has only half as many sentences as the former. Additionally, a parser trained on both the WSJ and Brown corpora performs less well on the Brown corpus than on the WSJ one. This leads us to the following questions that we would like to address in this paper: - Is there a difference in usefulness of techniques that are used to improve parser performance between the same-corpus and the different-corpus case? - Are different types of parsers (rule-based and statistical) equally sensitive to corpus variation? To achieve this, we compared the quality of the parses of a hand-crafted constraint-based parser and a statistical PCFG-based parser that was trained on a treebank of German newspaper text.
Using a qualitative analysis of disagreements from a referentially annotated newspaper corpus, we show that, in coreference annotation, vague referents are prone to greater disagreement. We show how potentially problematic cases can be dealt with in a way that is practical even for larger-scale annotation, considering a real-world example from newspaper text.
In this paper, we argue that difficulties in the definition of coreference itself contribute to lower inter-annotator agreement in certain cases. Data from a large referentially annotated corpus serves to corroborate this point, using a quantitative investigation to assess which effects or problems are likely to be the most prominent. Several examples where such problems occur are discussed in more detail, and we then propose a generalisation of Poesio, Reyle and Stevenson’s Justified Sloppiness Hypothesis to provide a unified model for these cases of disagreement and argue that a deeper understanding of the phenomena involved allows to tackle problematic cases in a more principled fashion than would be possible using only pre-theoretic intuitions.