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Myeloid-specific deletion of the AMPK2 subunit alters monocyte protein expression and atherogenesis
(2019)
The AMP-activated protein kinase (AMPK) is an energy sensing kinase that is activated by a drop in cellular ATP levels. Although several studies have addressed the role of the AMPKα1 subunit in monocytes and macrophages, little is known about the α2 subunit. The aim of this study was to assess the consequences of AMPKα2 deletion on protein expression in monocytes/macrophages, as well as on atherogenesis. A proteomics approach was applied to bone marrow derived monocytes from wild-type mice versus mice specifically lacking AMPKα2 in myeloid cells (AMPKα2∆MC mice). This revealed differentially expressed proteins, including methyltransferases. Indeed, AMPKα2 deletion in macrophages increased the ratio of S-adenosyl methionine to S-adenosyl homocysteine and increased global DNA cytosine methylation. Also, methylation of the vascular endothelial growth factor and matrix metalloproteinase-9 (MMP9) genes was increased in macrophages from AMPKα2∆MC mice, and correlated with their decreased expression. To link these findings with an in vivo phenotype, AMPKα2∆MC mice were crossed onto the ApoE-/- background and fed a western diet. ApoExAMPKα2∆MC mice developed smaller atherosclerotic plaques than their ApoExα2fl/fl littermates, that contained fewer macrophages and less MMP9 than plaques from ApoExα2fl/fl littermates. These results indicate that the AMPKα2 subunit in myeloid cells influences DNA methylation and thus protein expression and contributes to the development of atherosclerotic plaques.
Blunt thoracic trauma (TxT) deteriorates clinical post-injury outcomes. Ongoing inflammatory changes promote the development of post-traumatic complications, frequently causing Acute Lung Injury (ALI). Club Cell Protein (CC)16, a pulmonary anti-inflammatory protein, correlates with lung damage following TxT. Whether CC16-neutralization influences the inflammatory course during ALI is elusive. Ninety-six male CL57BL/6N mice underwent a double hit model of TxT and cecal ligation puncture (CLP, 24 h post-TxT). Shams underwent surgical procedures. CC16 was neutralized by the intratracheal application of an anti-CC16-antibody, either after TxT (early) or following CLP (late). Euthanasia was performed at 6 or 24 h post-CLP. Systemic and pulmonary levels of IL-6, IL-1β, and CXCL5 were determined, the neutrophils were quantified in the bronchoalveolar lavage fluid, and histomorphological lung damage was assessed. ALI induced a significant systemic IL-6 increase among all groups, while the local inflammatory response was most prominent after 24 h in the double-hit groups as compared to the shams. Significantly increased neutrophilic infiltration upon double hit was paralleled with the enhanced lung damage in all groups as compared to the sham, after 6 and 24 h. Neutralization of CC16 did not change the systemic inflammation. However, early CC16-neutralization increased the neutrophilic infiltration and lung injury at 6 h post-CLP, while 24 h later, the lung injury was reduced. Late CC16-neutralization increased neutrophilic infiltration, 24 h post-CLP, and was concurrent with an enhanced lung injury. The data confirmed the anti-inflammatory potential of endogenous CC16 in the murine double-hit model of ALI.
Latitudinal and bathymetrical species richness patterns in the NW Pacific and adjacent Arctic Ocean
(2019)
Global scale analyses have recently revealed that the latitudinal gradient in marine species richness is bimodal, peaking at low-mid latitudes but with a dip at the equator; and that marine species richness decreases with depth in many taxa. However, these overall and independently studied patterns may conceal regional differences that help support or qualify the causes in these gradients. Here, we analysed both latitudinal and depth gradients of species richness in the NW Pacific and its adjacent Arctic Ocean. We analysed 324,916 distribution records of 17,414 species from 0 to 10,900 m depth, latitude 0 to 90°N, and longitude 100 to 180°N. Species richness per c. 50 000 km2 hexagonal cells was calculated as alpha (local average), gamma (regional total) and ES50 (estimated species for 50 records) per latitudinal band and depth interval. We found that average ES50 and gamma species richness decreased per 5° latitudinal bands and 100 m depth intervals. However, average ES50 per hexagon showed that the highest species richness peaked around depth 2,000 m where the highest total number of species recorded. Most (83%) species occurred in shallow depths (0 to 500 m). The area around Bohol Island in the Philippines had the highest alpha species richness (more than 8,000 species per 50,000 km2). Both alpha and gamma diversity trends increased from the equator to latitude 10°N, then further decreased, but reached another peak at higher latitudes. The latitudes 60–70°N had the lowest gamma and alpha diversity where there is almost no ocean in our study area. Model selection on Generalized Additive Models (GAMs) showed that the combined effects of all environmental predictors produced the best model driving species richness in both shallow and deep sea. The results thus support recent hypotheses that biodiversity, while highest in the tropics and coastal depths, is decreasing at the equator and decreases with depth below ~2000 m. While we do find the declines of species richness with latitude and depth that reflect temperature gradients, local scale richness proved poorly correlated with many environmental variables. This demonstrates that while regional scale patterns in species richness may be related to temperature, that local scale richness depends on a greater variety of variables.
Feministische Erinnerungskulturen : 100 Jahre Frauenstimmrecht. 50 Jahre Autonome Frauenbewegung
(2019)
Completing banking union
(2019)
To complete banking union, there should be a single European deposit insurance scheme (EDIS) alongside the single supervisor and the single resolution authority. This would ensure uniformity across the Eurozone and facilitate the removal of barriers to the mobility of liquidity and capital within the single market. That in turn would promote efficiency in the banking sector and in the economy at large — just at the time that the EU needs to boost growth in order to remain competitive with the US and China.
The EDIS promise to promptly reimburse insured deposits at a failed bank in the Eurozone should be unconditional. But who will stand behind that commitment? Who is the “E” in EDIS? Is its promise credible, even in a crisis? If a deposit guarantee scheme fails to deliver what people expect, panic would very likely erupt. Instead of strengthening financial stability, deposit insurance could destroy it.
Yet this is the risk that current proposals pose. They create the impression that there will be a single deposit guarantee scheme. There will not. Instead, there will be a complex set of liquidity and reinsurance arrangements among Member State schemes.
These defects need to be remedied. To do so, we propose creating a European Deposit Insurance Corporation (EDIC) alongside national schemes. For banks that meet EDIC’s strict entry criteria and decide to become members, EDIC will promise to reimburse promptly — in the event the member bank fails — 100 cents on the euro in euro for each euro of insured deposits, regardless of the Eurozone Member State in which the bank is headquartered.
In effect, the single deposit guarantee scheme would be created via migration to EDIC rather than mutualisation of existing schemes. This would increase the mobility of capital and liquidity and lead to a convergence of interest rates across the Eurozone. That in turn will improve the effectiveness of monetary policy, foster integration and promote growth.
This thesis investigates the acquisition of compositional and lexical semantic properties of adjectives in German-speaking children between the age of two and five years.
According to formal semantic approaches, there are intersective and non-intersective adjectives, subsective and non-subsective adjectives as well as gradable and non-gradable adjectives. These properties concern the compositional mechanisms involved in nominal modification, i.e., the combination of adjectives and nouns. In addition, adjectives differ regarding lexical semantic properties that contribute to the adjectives' meaning. Differences in the adjectives' scale structure have led to the theoretical assumption that gradable adjectives should be distinguished into relative and absolute gradable adjectives. In addition, meaning components such as multidimensionality or subjectivity have led to the distinction between dimensional and evaluative gradable adjectives. These properties have been mostly investigated independently of each other in both theory and acquisition research. I suggest a classification system for adjectives that combines different semantic properties. This system results in six adjective classes constituting a Semantic Complexity Hierarchy. Assuming that these adjective classes differ in semantic complexity, I propose an operationalization of semantic complexity that takes into account the adjectives' length of description, their type complexity, and lexical properties that contribute to the adjectives' meaning.
Regarding the question of how monolingual German-speaking children acquire the semantics of adjectives, I hypothesize that the order of acquisition of adjectives is determined by their semantic complexity. This hypothesis is tested in a spontaneous speech study and a comprehension experiment.
The spontaneous speech study is a longitudinal investigation of the production of adjectives from 2;00 to 2;11 years based on transcripts from a dense data corpus. The results provide evidence that the mean age of acquisition for the adjective classes in the Semantic Complexity Hierarchy follows the order predicted by semantic complexity. The same order was observed for the age at which the number of types for each class increased most. A preliminary analysis of the input indicates that the frequency of parental adjective use is related to the order of acquisition, but it is unlikely that frequency determines the order completely.
The comprehension experiment focuses on two specific adjective classes. I examine children's and adults' interpretation of relative (big, small) and absolute (clean, dirty) gradable dimensional adjectives with a picture-choice task. These two classes are of the same semantic complexity because they are both gradable, but they have different scale structures. As a result, they must be interpreted differently due to lexical semantic properties. I investigate whether children calculate different standards of comparison for relative and absolute gradable adjectives and whether they distinguish between relative and absolute gradable adjectives regarding the relevance of the explicit comparison class. The results indicate that as of age 3, children distinguish between relative and absolute gradable adjectives with regard to the standard of comparison. However, with respect to the relevance of the comparison class, for 3-year-old children, unlike for 4- and 5-year-olds, changes in the noun, i.e., in the explicit comparison class, led to non-adult-like responses regarding both relative and absolute gradable adjectives.
On the basis of the empirical findings, I propose an acquisition path stating that children enter the acquisition process with inherent linguistic knowledge, the Semantic Complexity Hierarchy, and cognitive abilities to categorize their environment. I suggest that initially, children apply the least complex interpretation available in the Semantic Complexity Hierarchy to all adjectives: all adjectives are interpreted as properties of individuals that are not gradable. To access other levels of the Semantic Complexity Hierarchy and to establish more complex adjective classes, positive evidence from the input and conceptual properties of adjectives, e.g., COLOR, MENTAL STATE, PHYSICAL PROPERTY etc., can operate as triggers.
This study investigates macrostructure in elicited narratives of 69 monolingual German-, Russian- and Swedish-speaking adults. Using the LITMUS-MAIN (Multilingual Assessment Instrument for Narratives), and its Baby Goats and Baby Birds stories, story structure and story complexity, concerning episodic organization, were examined across the 3 languages. As theoretical underpinnings, a multidimensional model of macrostructure was used. This model includes analyses of story structure (SS), in which a narrative merits a maximum score of 17, based on the occurrence of five types of macrostructural components (Internal states as initiating event and as reaction, Goal, Attempt and Outcome), and of story complexity (SC), which measures combinations of Goals, Attempts and Outcomes within one episode. The highest attainable complexity is the GAO-sequence, when a Goal, Attempt and Outcome are produced within the same episode. The results for SS were similar for German, Russian and Swedish, where adults included 11-12 components per story. A more detailed analysis of the individual components revealed striking similarities across the 3 languages, both for frequently used and seldom occurring components. SC did not differ significantly across languages nor across stories, whilst for SS, a slight difference between the two stories was found. We interpret this finding as story complexity (a qualitative measure of macrostructure) being of a more universal nature. Furthermore, our results indicate that caution is warranted when conclusions about children’s narrative skills are to be drawn on the basis of the MAIN Baby Goats and Baby Birds stories.
For this study one hundred sixty-seven Russian-/Turkish-German preschool children were tested with a battery of language proficiency tests in both languages. On the basis of 1.5 SD below monolingual norm for L2 German and 1.25 SD below bilingual mean for either home language, 9 children at risk of developmental language disorders (DLD) (mean age of 4 years and 5 months) were identified and 16 age-matched TD children were selected out of the cohort. All these children were tested with the LITMUS-MAIN and –SR tests in German. The results across TD and at risk of DLD group were compared. TD clearly outperformed at risk of DLD in SR. In elicited narratives, macrostructure and microstructure were scrutinized across groups. Similar to the previous findings, our results show significant differences between at risk of DLD und TD in the microstructure, e.g. total number of word tokens and verb-based communication units and SR. For the macrostructure, TD outperformed at risk children only for story complexity. The study expands our knowledge on the cut-off criteria for the identification of bilinguals at risk of DLD, scrutinized very early narratives for bilinguals at risk of DLD features and questions the similarity of cognitive skills in TD and at risk of DLD children.