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The interaction between Syntax and Phonology has been one area of interesting empirical research and theoretical debate in recent years, particularly the question of the extent to which syntactic structure influences phonological phrasing. It has generally been observed that the edges of the major syntactic constituents (XPs) tend to coincide with prosodic phrase boundaries thus resulting in XPs like subject NPs, object NPs, Topic NPs, VPs etc. forming separate phonological phrases. Within Optimality Theoretic (OT) accounts, this fact has been attributed to a number of well-motivated general alignment constraints. Studies on relative clauses in Bantu and other languages have significantly contributed to this area of research inquiry where a number of parametric variations have been observed with regard to prosodic phrasing. In some languages, XPs which are heads of relatives form separate phonological phrases while in others they phrase with the relative clauses. This paper makes a contribution to this topic by discussing the phrasing of relatives in Ciwandya (a Bantu language spoken in Malawi and Tanzania). It shows that XPs which are heads of restrictive relative clauses phrase with their relative verbs, regardless of whether they are subjects, objects or other adjuncts. A variety of syntactic constructions are used to illustrate this fact. The discussion also confirms what has been generally observed in other Bantu languages concerning restrictive relatives with clefts and non-restrictive relative clauses. In both cases, the heads of the relatives phrase separately. The paper adopts an OT analysis which has been well articulated and defended in Cheng & Downing (2007, 2010, to appear) Downing & Mtenje (2010, 2011) to account for these phenomena in Ciwandya.
Introduction
(2011)
In spite of this long history, most work to date on the phonology-syntax interface in Bantu languages suffers from limitations, due to the range of expertise required: intonation, phonology, syntax. Quite generally, intonational studies on African languages are extremely rare. Most of the existing data has not been the subject of careful phonetic analysis, whether of the prosody of neutral sentences or of questions or other focus structures. There are important gaps in our knowledge of Bantu syntax which in turn limit our understanding of the phonology-syntax interface. Recent developments in syntactic theory have provided a new way of thinking about the type of syntactic information that phonology can refer to and have raised new questions: Do only syntactic constituent edges condition prosodic phrasing? Do larger domains such as syntactic phases, or even other factors, like argument and adjunct distinctions, play a role? Further, earlier studies looked at a limited range of syntactic constructions. Little research exists on the phonology of focus or of sentences with non-canonical word order in Bantu languages. Both the prosody and the syntax of complex sentences, questions and dislocations are understudied for Bantu languages. Our project aims to remedy these gaps in our knowledge by bringing together a research team with all the necessary expertise. Further, by undertaking the intonational, phonological and syntactic analysis of several languages we can investigate whether there is any correlation among differences in morphosyntactic and prosodic properties that might also explain differences in phrasing and intonation. It will also allow us to investigate whether there are cross-linguistically common prosodic patterns for particular morpho-syntactic structure.
We show that wh-words are a tool to investigate the prosodic structure of Bàsàa. Our claim is that the end of an Intonation Phrase (IP) can be identified by the presence of a long vowel on the wh-word. We propose that wh-words, which sometimes surface as C´V and sometimes as C´V´V, are underlyingly of the C´V form and they introduce a floating H. Whenever the association of this floating H with the first tone bearing unit that follows the wh-word is prevented by the presence of an IP boundary, a mora is created on the wh-word in order to realize the floating H. We briefly discuss the interface approach of Immediately After the Verb (IAV) focus (Costa and Kula, 2008) and we show that Bàsàa wh-questions and answers do not support this hypothesis. Finally, Bàsàa fronted whphrases, just like Hausa’s fronted foci (Leben et al., 1989), seem to provide support to the idea that intonational effects are also at play in the present tone language.
High grade gliomas, including anaplastic glioma WHO grade III and glioblastoma WHO IV (GBM), carry a dismal prognosis. Taking all nowadays-available therapeutics options, including radiation, chemotherapy and surgery, for GBM into consideration the prognosis after initial diagnosis is about 12 month. Despite this bad prognosis, researchers gained a tremendous insight into the molecular and genetic signatures of low and high grade gliomas. Several different subtypes of GBM were demonstrated with respect to their genetic background. These genetic alterations include p53 mutation in secondary GBMs and EGFR amplification in primary GBMs, respectively. Very recently, great excitement was raised after the discovery of IDH1 mutation in low-grade gliomas and secondary GBMs. This discovery is of great significance since it allows further categorizing of GBMs and is helpful in distinguishing low-grade gliomas from non-neoplastic adjacent brain tissue. Despite all this progress there is an urgent need for fresh additional therapeutic strategies. In addition to the identification of novel therapeutic regimens it is of utmost importance to gain an understanding about the molecular mechanisms on how GBMs manage to evade from almost any anti-cancer treatment regimen. In experimental models of glioblastoma there are a number of novel therapeutic regimens that exhibited promising results. These novel therapeutics include, but are not limited to: Apoptosis-based therapeutics (Tumor necrosis factor alpha related apoptosis inducing ligand, TRAIL), tyrosinkinase-inhibitors, Heat-shock-protein 90 (HSP90) inhibitors, polyphenols, novel drug combinations and intracranial application based strategies. This chapter will primarily review and focus on molecular mechanisms of resistance in GBM and rising new therapeutic venues for high-grade gliomas. High-grade gliomas are a group of primary heterogenous tumors of which glioblastoma World Health Organisation, WHO IV (GBM), is the most common one. Once the diagnosis of GBM is made, the average survival time is approximately 12-15 month (Hegi, Diserens et al., 2005). Treatment usually consists of temozolomide (commonly used chemotherapeutic drug for the treatment of GBM, TMZ), radiation (either alone or in combination with chemotherapeutics) and surgery (Hegi, Diserens et al., 2005)...
Application of the liposuction techniques and principles in specific body areas and pathologies
(2011)
The buttocks have been a symbol of attraction, sexuality and eroticism since ancient times and therefore, they have an important role in defining the posterior body contour. More and more people are talking about and understand the meaning and the role that buttocks play in modeling and physical beauty. The three dimensional gluteoplasty (3-DGP) is an innovative technique that allows us to change volume, shape and firmness, not only in the buttocks but also in the adjacent regions such as the thighs and trochanters, becoming an ideal tool to answer the frequent reasons of consultation of our patients about this particular area of the body: ...
There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints. All the already mentioned evaluation tools are dosimetric only without taking into account the radiobiological characteristics of tumors or OARs. It has been demonstrated that although competing treatment plans might have similar mean, maximum or minimum doses they may have significantly different clinical outcomes (Mavroidis et al. 2001). For performing a more complete treatment plan evaluation and comparison the complication-free tumor control probability (P+) and the biologically effective uniform dose (D ) have been proposed (Källman et al. 1992a, Mavroidis et al. 2000). The D concept denotes that any two dose distributions within a target or OAR are equivalent if they produce the same probability for tumor control or normal tissue complication, respectively (Mavroidis et al. 2001)...
Temporal regularity allows predicting the temporal locus of future information thereby potentially facilitating cognitive processing. We applied event-related brain potentials (ERPs) to investigate how temporal regularity impacts pre-attentive and attentive processing of deviance in the auditory modality. Participants listened to sequences of sinusoidal tones differing exclusively in pitch. The inter-stimulus interval (ISI) in these sequences was manipulated to convey either isochronous or random temporal structure. In the pre-attentive session, deviance processing was unaffected by the regularity manipulation as evidenced in three event-related-potentials (ERPs): mismatch negativity (MMN), P3a, and reorienting negativity (RON). In the attentive session, the P3b was smaller for deviant tones embedded in irregular temporal structure, while the N2b component remained unaffected. These findings confirm that temporal regularity can reinforce cognitive mechanisms associated with the attentive processing of deviance. Furthermore, they provide evidence for the dynamic allocation of attention in time and dissociable pre-attentive and attention-dependent temporal processing mechanisms.
Koreferenzielle Pro-Formen im Deutschen und Italienischen : Analyse von Korpora gesprochener Sprache
(2011)
Gegenstand dieses Beitrags ist die vergleichende Untersuchung von deutschen und italienischen verweisenden Pronomen. Für das Deutsche wird die Alternanz zwischen der/die/ das (im Folgenden d-Pronomen; vgl. Ahrenholz 2007 und Wiltschko 1998) und Personalpronomen betrachtet. Für das Italienische werden Demonstrativ- und Personalpronomen (freie und klitische) untersucht. In vorherigen Forschungsarbeiten wurde auf semantische, syntaktische und pragmatische Bedingungen hingewiesen, die das Vorkommen von d-Pronomen anstatt anderer Pronominalformen wie z.B. den Personalpronomen im Deutschen stark begünstigen (vgl. dazu Ravetto 2009). Ziel dieser Arbeit ist, zu überprüfen, ob in den zwei Vergleichssprachen ähnliche Tendenzen bzw. Bedingungen zu beobachten sind, die mit der Wahl der jeweiligen verweisenden Form verknüpft sind.
Neue Vorschläge in der Valenzlexikographie am Beispiel des spanisch-deutschen Verbvalenzwörterbuchs
(2011)
Structural biology and life sciences in general, and NMR in particular, have always been associated with advanced computing. The current challenges in the post-genomic era call for virtual research platforms that provide the worldwide research community with both user-friendly tools, platforms for data analysis and exchange, and an underlying e-Infrastructure. WeNMR, a three-year European Commission co-funded project started in November 2010, groups different research teams into a worldwide virtual research community. It builds on the established eNMR e-Infrastructure and its steadily growing virtual organisation, which is currently the second largest VO in the area of life sciences. WeNMR provides an e-Infrastructure platform and Science Gateway for structural biology. It involves researchers from around the world and will build bridges to other areas of structural biology.